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Patent code US10562844

Compile Data Set for Download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433365
PNG
(US10562844, Compound 16)
Show SMILES OC(=O)C1CSC(O)(O)C1
Show InChI InChI=1S/C5H8O4S/c6-4(7)3-1-5(8,9)10-2-3/h3,8-9H,1-2H2,(H,6,7)
GoogleScholar
UniChem
US Patent
n/an/a 2.90E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433361
PNG
(US10562844, Compound 13)
Show SMILES OC(=O)C1CSC(=O)C1
Show InChI InChI=1S/C5H6O3S/c6-4-1-3(2-9-4)5(7)8/h3H,1-2H2,(H,7,8)
GoogleScholar
UniChem
US Patent
n/an/a 3.20E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433364
PNG
(US10562844, Compound 14)
Show SMILES O[C@@H]1C[C@H](CS1)C(O)=O
Show InChI InChI=1S/C5H8O3S/c6-4-1-3(2-9-4)5(7)8/h3-4,6H,1-2H2,(H,7,8)/t3-,4+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 3.30E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433363
PNG
(US10562844, Compound 15)
Show SMILES O[C@H]1C[C@H](CS1)C(O)=O
Show InChI InChI=1S/C5H8O3S/c6-4-1-3(2-9-4)5(7)8/h3-4,6H,1-2H2,(H,7,8)/t3-,4-/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 3.70E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433359
PNG
(US10562844, Compound 11)
Show SMILES OC(=O)[C@@H]1CCC(=O)C1
Show InChI InChI=1S/C6H8O3/c7-5-2-1-4(3-5)6(8)9/h4H,1-3H2,(H,8,9)/t4-/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 3.70E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433358
PNG
(US10562844, Compound 10)
Show SMILES OC(=O)C1CCC(=O)C1
Show InChI InChI=1S/C6H8O3/c7-5-2-1-4(3-5)6(8)9/h4H,1-3H2,(H,8,9)
GoogleScholar
UniChem
US Patent
n/an/a 3.80E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433360
PNG
(US10562844, Compound 8)
Show SMILES O[C@H]1CC[C@H](CC(O)=O)C1
Show InChI InChI=1S/C7H12O3/c8-6-2-1-5(3-6)4-7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6-/m0/s1
GoogleScholar
UniChem
US Patent
n/an/a 4.80E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433357
PNG
(US10562844, Compound 7)
Show SMILES O[C@H]1CCC(C1)C(O)=O
Show InChI InChI=1S/C6H10O3/c7-5-2-1-4(3-5)6(8)9/h4-5,7H,1-3H2,(H,8,9)/t4?,5-/m0/s1
GoogleScholar
UniChem
US Patent
n/an/a 6.00E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433355
PNG
(US10562844, Compound 9)
Show SMILES N[C@H]1CCC(C1)C(O)=O
Show InChI InChI=1S/C6H11NO2/c7-5-2-1-4(3-5)6(8)9/h4-5H,1-3,7H2,(H,8,9)/t4?,5-/m0/s1
GoogleScholar
UniChem
US Patent
n/an/a 6.30E+5n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433362
PNG
(US10562844, Compound 12)
Show SMILES OC1CC(CS1)C(O)=O
Show InChI InChI=1S/C5H8O3S/c6-4-1-3(2-9-4)5(7)8/h3-4,6H,1-2H2,(H,7,8)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+6n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433354
PNG
(US10562844, Compound 2)
Show SMILES OC(=O)C1CCCO1
Show InChI InChI=1S/C5H8O3/c6-5(7)4-2-1-3-8-4/h4H,1-3H2,(H,6,7)
GoogleScholar
PDB
UniChem
US Patent
n/an/a 1.50E+6n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433351
PNG
(US10562844, Compound 5)
Show SMILES OC1CCC(C1)C(O)=O
Show InChI InChI=1S/C6H10O3/c7-5-2-1-4(3-5)6(8)9/h4-5,7H,1-3H2,(H,8,9)
GoogleScholar
UniChem
US Patent
n/an/a 2.10E+6n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433349
PNG
(US10562844, Compound 1)
Show SMILES CC1CC(NN1)C(O)=O
Show InChI InChI=1S/C5H10N2O2/c1-3-2-4(5(8)9)7-6-3/h3-4,6-7H,2H2,1H3,(H,8,9)
GoogleScholar
UniChem
US Patent
n/an/a 2.90E+6n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
Hydroxyproline dehydrogenase (HYPDH)(147-515)


(Homo sapiens (Human))
BDBM433356
PNG
(US10562844, Compound 6)
Show SMILES O[C@@H]1CCC(C1)C(O)=O
Show InChI InChI=1S/C6H10O3/c7-5-2-1-4(3-5)6(8)9/h4-5,7H,1-3H2,(H,8,9)/t4?,5-/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a>1.00E+7n/an/an/an/an/an/a



Wake Forest University Health Sciences; UAB Research Foundation

US Patent


Assay Description
In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...


US Patent US10562844 (2020)


BindingDB Entry DOI: 10.7270/Q2KH0QQ5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%