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Patent code US10562853

Compile Data Set for Download or QSAR
Found 189 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433537
PNG
(US10562853, Compound 60)
Show SMILES CC1(C)Cc2cccc(OCCNCC3(F)CCN(CC3)C(=O)c3ccc(F)c(Cl)c3)c2O1
Show InChI InChI=1S/C25H29ClF2N2O3/c1-24(2)15-18-4-3-5-21(22(18)33-24)32-13-10-29-16-25(28)8-11-30(12-9-25)23(31)17-6-7-20(27)19(26)14-17/h3-7,14,29H,8-13,15-16H2,1-2H3
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0.0100n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433479
PNG
(US10562853, Compound 5)
Show SMILES Fc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-18-12-15(4-5-19(18)24)20(28)27-9-6-21(25,7-10-27)14-26-8-11-29-17-3-1-2-16(23)13-17/h1-5,12-13,26H,6-11,14H2
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0.0230n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433491
PNG
(US10562853, Compound 12)
Show SMILES CSc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H25ClF2N2O2S/c1-30-20-5-3-2-4-19(20)29-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-18(24)17(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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0.0290n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433480
PNG
(US10562853, Compound 6)
Show SMILES COc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-19-4-2-3-5-20(19)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-18(24)17(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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0.0350n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433478
PNG
(US10562853, Compound 4)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(Cl)c2)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-2-1-3-17(13-16)29-11-8-26-14-21(25)6-9-27(10-7-21)20(28)15-4-5-19(24)18(23)12-15/h1-5,12-13,26H,6-11,14H2
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0.0430n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433549
PNG
(US10562853, Compound 70)
Show SMILES Fc1ccnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-16-11-14(1-2-17(16)23)19(28)27-8-4-20(24,5-9-27)13-25-7-10-29-18-12-15(22)3-6-26-18/h1-3,6,11-12,25H,4-5,7-10,13H2
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0.0500n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433483
PNG
(US10562853, Compound 8)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-20(24)19(23)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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0.0520n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433484
PNG
(US10562853, Compound 9)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-19(23)20(24)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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0.0570n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433474
PNG
(US10562853, Compound 1)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2)CC1
Show InChI InChI=1S/C21H23ClF2N2O2/c22-18-14-16(6-7-19(18)23)20(27)26-11-8-21(24,9-12-26)15-25-10-13-28-17-4-2-1-3-5-17/h1-7,14,25H,8-13,15H2
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0.0610n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433501
PNG
(US10562853, Compound 18)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccn2)CC1
Show InChI InChI=1S/C20H22ClF2N3O2/c21-16-13-15(4-5-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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0.0650n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433477
PNG
(US10562853, Compound 3)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C23H26Cl2FN3O3/c1-16(30)28-18-3-2-4-19(14-18)32-12-9-27-15-23(26)7-10-29(11-8-23)22(31)17-5-6-20(24)21(25)13-17/h2-6,13-14,27H,7-12,15H2,1H3,(H,28,30)
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0.0730n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433508
PNG
(US10562853, Compound 26)
Show SMILES CNc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H25ClF2N4O2/c1-25-18-3-2-4-19(27-18)30-12-9-26-14-21(24)7-10-28(11-8-21)20(29)15-5-6-17(23)16(22)13-15/h2-6,13,26H,7-12,14H2,1H3,(H,25,27)
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0.0800n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433509
PNG
(US10562853, Compound 27)
Show SMILES CN(C)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C22H27ClF2N4O2/c1-28(2)19-4-3-5-20(27-19)31-13-10-26-15-22(25)8-11-29(12-9-22)21(30)16-6-7-18(24)17(23)14-16/h3-7,14,26H,8-13,15H2,1-2H3
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0.0800n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433476
PNG
(US10562853, Compound 2)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C23H26ClF2N3O3/c1-16(30)28-18-3-2-4-19(14-18)32-12-9-27-15-23(26)7-10-29(11-8-23)22(31)17-5-6-21(25)20(24)13-17/h2-6,13-14,27H,7-12,15H2,1H3,(H,28,30)
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0.0830n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433546
PNG
(US10562853, Compound 68)
Show SMILES COc1ccnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-16-4-7-26-19(13-16)30-11-8-25-14-21(24)5-9-27(10-6-21)20(28)15-2-3-18(23)17(22)12-15/h2-4,7,12-13,25H,5-6,8-11,14H2,1H3
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0.0900n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433526
PNG
(US10562853, Compound 47)
Show SMILES NC(=O)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H24ClF2N3O3/c23-18-13-16(4-5-19(18)24)21(30)28-9-6-22(25,7-10-28)14-27-8-11-31-17-3-1-2-15(12-17)20(26)29/h1-5,12-13,27H,6-11,14H2,(H2,26,29)
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0.100n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433523
PNG
(US10562853, Compound 44)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3[nH]ccc23)CC1
Show InChI InChI=1S/C23H24ClF2N3O2/c24-18-14-16(4-5-19(18)25)22(30)29-11-7-23(26,8-12-29)15-27-10-13-31-21-3-1-2-20-17(21)6-9-28-20/h1-6,9,14,27-28H,7-8,10-13,15H2
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0.100n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433499
PNG
(US10562853, Compound 16)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3cccnc23)CC1
Show InChI InChI=1S/C24H24ClF2N3O2/c25-19-15-18(6-7-20(19)26)23(31)30-12-8-24(27,9-13-30)16-28-11-14-32-21-5-1-3-17-4-2-10-29-22(17)21/h1-7,10,15,28H,8-9,11-14,16H2
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0.150n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433494
PNG
(US10562853, Compound 14)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3OCCOc23)CC1
Show InChI InChI=1S/C23H25ClF2N2O4/c24-17-14-16(4-5-18(17)25)22(29)28-9-6-23(26,7-10-28)15-27-8-11-30-19-2-1-3-20-21(19)32-13-12-31-20/h1-5,14,27H,6-13,15H2
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0.180n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433495
PNG
(US10562853, Compound 15)
Show SMILES FC1(CNCCOc2cccc3OCCOc23)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H25Cl2FN2O4/c24-17-5-4-16(14-18(17)25)22(29)28-9-6-23(26,7-10-28)15-27-8-11-30-19-2-1-3-20-21(19)32-13-12-31-20/h1-5,14,27H,6-13,15H2
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0.200n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433554
PNG
(US10562853, Compound 74)
Show SMILES FC1(CNCCOc2ccccn2)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H22Cl2FN3O2/c21-16-5-4-15(13-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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0.200n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433531
PNG
(US10562853, Compound 52)
Show SMILES CNc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H26ClF2N3O2/c1-26-17-3-2-4-18(14-17)30-12-9-27-15-22(25)7-10-28(11-8-22)21(29)16-5-6-20(24)19(23)13-16/h2-6,13-14,26-27H,7-12,15H2,1H3
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0.200n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433552
PNG
(US10562853, Compound 72)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(Cl)n2)CC1
Show InChI InChI=1S/C20H21Cl2F2N3O2/c21-15-12-14(4-5-16(15)23)19(28)27-9-6-20(24,7-10-27)13-25-8-11-29-18-3-1-2-17(22)26-18/h1-5,12,25H,6-11,13H2
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0.200n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433524
PNG
(US10562853, Compound 45)
Show SMILES CN(C)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C23H28ClF2N3O2/c1-28(2)18-4-3-5-19(15-18)31-13-10-27-16-23(26)8-11-29(12-9-23)22(30)17-6-7-21(25)20(24)14-17/h3-7,14-15,27H,8-13,16H2,1-2H3
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US Patent
0.200n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433527
PNG
(US10562853, Compound 48)
Show SMILES NC(=O)c1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H24ClF2N3O3/c23-17-13-15(5-6-18(17)24)21(30)28-10-7-22(25,8-11-28)14-27-9-12-31-19-4-2-1-3-16(19)20(26)29/h1-6,13,27H,7-12,14H2,(H2,26,29)
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0.200n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433539
PNG
(US10562853, Compound 62)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2Cl)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-3-1-2-4-19(16)29-12-9-26-14-21(25)7-10-27(11-8-21)20(28)15-5-6-18(24)17(23)13-15/h1-6,13,26H,7-12,14H2
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0.200n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433548
PNG
(US10562853, Compound 69)
Show SMILES Fc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-16-11-14(1-3-17(16)23)19(28)27-8-5-20(24,6-9-27)13-25-7-10-29-18-4-2-15(22)12-26-18/h1-4,11-12,25H,5-10,13H2
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0.25n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433507
PNG
(US10562853, Compound 25)
Show SMILES Fc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-15-12-14(4-5-16(15)22)19(28)27-9-6-20(24,7-10-27)13-25-8-11-29-18-3-1-2-17(23)26-18/h1-5,12,25H,6-11,13H2
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0.280n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433525
PNG
(US10562853, Compound 46)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C22H22ClF5N2O2/c23-18-12-15(4-5-19(18)24)20(31)30-9-6-21(25,7-10-30)14-29-8-11-32-17-3-1-2-16(13-17)22(26,27)28/h1-5,12-13,29H,6-11,14H2
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0.300n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433538
PNG
(US10562853, Compound 61)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2F)CC1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-16-13-15(5-6-17(16)23)20(28)27-10-7-21(25,8-11-27)14-26-9-12-29-19-4-2-1-3-18(19)24/h1-6,13,26H,7-12,14H2
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0.300n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433482
PNG
(US10562853, Compound 7)
Show SMILES COc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-19-4-2-3-5-20(19)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-17(23)18(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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0.380n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM50328639
PNG
((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Show SMILES Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H22ClF2N3O/c1-14-2-4-16(25-11-14)12-24-13-20(23)6-8-26(9-7-20)19(27)15-3-5-18(22)17(21)10-15/h2-5,10-11,24H,6-9,12-13H2,1H3
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US Patent
0.400n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433505
PNG
(US10562853, Compound 23)
Show SMILES COc1cccnc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-18-3-2-8-26-19(18)30-12-9-25-14-21(24)6-10-27(11-7-21)20(28)15-4-5-17(23)16(22)13-15/h2-5,8,13,25H,6-7,9-12,14H2,1H3
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0.400n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433528
PNG
(US10562853, Compound 51)
Show SMILES CNc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H26ClF2N3O2/c1-26-19-4-2-3-5-20(19)30-13-10-27-15-22(25)8-11-28(12-9-22)21(29)16-6-7-18(24)17(23)14-16/h2-7,14,26-27H,8-13,15H2,1H3
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0.400n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433500
PNG
(US10562853, Compound 17)
Show SMILES FC1(CNCCOc2cccc3cccnc23)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H24Cl2FN3O2/c25-19-7-6-18(15-20(19)26)23(31)30-12-8-24(27,9-13-30)16-28-11-14-32-21-5-1-3-17-4-2-10-29-22(17)21/h1-7,10,15,28H,8-9,11-14,16H2
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0.450n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433535
PNG
(US10562853, Compound 58)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C22H25ClF2N4O3/c1-15(30)27-19-3-2-4-20(28-19)32-12-9-26-14-22(25)7-10-29(11-8-22)21(31)16-5-6-18(24)17(23)13-16/h2-6,13,26H,7-12,14H2,1H3,(H,27,28,30)
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0.5n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433544
PNG
(US10562853, Compound 66)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-18-3-2-4-19(26-18)30-12-9-25-14-21(24)7-10-27(11-8-21)20(28)15-5-6-17(23)16(22)13-15/h2-6,13,25H,7-12,14H2,1H3
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0.5n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433541
PNG
(US10562853, Compound 63)
Show SMILES Cc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O2/c1-16-3-2-4-18(13-16)29-12-9-26-15-22(25)7-10-27(11-8-22)21(28)17-5-6-20(24)19(23)14-17/h2-6,13-14,26H,7-12,15H2,1H3
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0.5n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433492
PNG
(US10562853, Compound 13)
Show SMILES CSc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H25Cl2FN2O2S/c1-30-20-5-3-2-4-19(20)29-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-17(23)18(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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0.5n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433506
PNG
(US10562853, Compound 24)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cc(ccn2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H21ClF5N3O2/c22-16-11-14(1-2-17(16)23)19(31)30-8-4-20(24,5-9-30)13-28-7-10-32-18-12-15(3-6-29-18)21(25,26)27/h1-3,6,11-12,28H,4-5,7-10,13H2
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0.550n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433515
PNG
(US10562853, Compound 36)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cnccn2)CC1
Show InChI InChI=1S/C19H21ClF2N4O2/c20-15-11-14(1-2-16(15)21)18(27)26-8-3-19(22,4-9-26)13-24-7-10-28-17-12-23-5-6-25-17/h1-2,5-6,11-12,24H,3-4,7-10,13H2
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0.570n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433516
PNG
(US10562853, Compound 39)
Show SMILES COc1cccc(SCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O2S/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-20(24)19(23)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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0.700n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433542
PNG
(US10562853, Compound 64)
Show SMILES Fc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-18-13-15(1-6-19(18)24)20(28)27-10-7-21(25,8-11-27)14-26-9-12-29-17-4-2-16(23)3-5-17/h1-6,13,26H,7-12,14H2
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0.800n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433553
PNG
(US10562853, Compound 73)
Show SMILES Cc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H24ClF2N3O2/c1-15-3-2-4-19(26-15)29-12-9-25-14-21(24)7-10-27(11-8-21)20(28)16-5-6-18(23)17(22)13-16/h2-6,13,25H,7-12,14H2,1H3
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0.900n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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0.900n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433545
PNG
(US10562853, Compound 67)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-16-3-5-19(26-13-16)30-11-8-25-14-21(24)6-9-27(10-7-21)20(28)15-2-4-18(23)17(22)12-15/h2-5,12-13,25H,6-11,14H2,1H3
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1.10n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433486
PNG
(US10562853, Compound 11)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-17-3-5-18(6-4-17)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-2-7-19(23)20(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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1.20n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433532
PNG
(US10562853, Compound 53)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCNc2ccccc2)CC1
Show InChI InChI=1S/C21H24ClF2N3O/c22-18-14-16(6-7-19(18)23)20(28)27-12-8-21(24,9-13-27)15-25-10-11-26-17-4-2-1-3-5-17/h1-7,14,25-26H,8-13,15H2
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1.30n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433502
PNG
(US10562853, Compound 19)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccnc2)CC1
Show InChI InChI=1S/C20H22ClF2N3O2/c21-17-12-15(3-4-18(17)22)19(27)26-9-5-20(23,6-10-26)14-25-8-11-28-16-2-1-7-24-13-16/h1-4,7,12-13,25H,5-6,8-11,14H2
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1.70n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433510
PNG
(US10562853, Compound 29)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)N2CCCC2)CC1
Show InChI InChI=1S/C24H29ClF2N4O2/c25-19-16-18(6-7-20(19)26)23(32)31-13-8-24(27,9-14-31)17-28-10-15-33-22-5-3-4-21(29-22)30-11-1-2-12-30/h3-7,16,28H,1-2,8-15,17H2
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1.70n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433519
PNG
(US10562853, Compound 40)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCSc2ccccn2)CC1
Show InChI InChI=1S/C20H22ClF2N3OS/c21-16-13-15(4-5-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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1.80n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433536
PNG
(US10562853, Compound 59)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCCc2ccccc2)CC1
Show InChI InChI=1S/C22H25ClF2N2O/c23-19-15-18(8-9-20(19)24)21(28)27-13-10-22(25,11-14-27)16-26-12-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-9,15,26H,4,7,10-14,16H2
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2n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433534
PNG
(US10562853, Compound 55)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCCc2ccccn2)CC1
Show InChI InChI=1S/C21H24ClF2N3O/c22-18-14-16(6-7-19(18)23)20(28)27-12-8-21(24,9-13-27)15-25-10-3-5-17-4-1-2-11-26-17/h1-2,4,6-7,11,14,25H,3,5,8-10,12-13,15H2
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2.5n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433511
PNG
(US10562853, Compound 30)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)-n2cccn2)CC1
Show InChI InChI=1S/C23H24ClF2N5O2/c24-18-15-17(5-6-19(18)25)22(32)30-12-7-23(26,8-13-30)16-27-10-14-33-21-4-1-3-20(29-21)31-11-2-9-28-31/h1-6,9,11,15,27H,7-8,10,12-14,16H2
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2.70n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433533
PNG
(US10562853, Compound 54)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCNc2ccccn2)CC1
Show InChI InChI=1S/C20H23ClF2N4O/c21-16-13-15(4-5-17(16)22)19(28)27-11-6-20(23,7-12-27)14-24-9-10-26-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2,(H,25,26)
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2.70n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433551
PNG
(US10562853, Compound 71)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H21ClF5N3O2/c22-15-12-14(4-5-16(15)23)19(31)30-9-6-20(24,7-10-30)13-28-8-11-32-18-3-1-2-17(29-18)21(25,26)27/h1-5,12,28H,6-11,13H2
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3.70n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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5n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433543
PNG
(US10562853, Compound 65)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-2-4-17(5-3-16)29-12-9-26-14-21(25)7-10-27(11-8-21)20(28)15-1-6-19(24)18(23)13-15/h1-6,13,26H,7-12,14H2
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5.5n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433504
PNG
(US10562853, Compound 22)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccc(Cl)cn2)CC1
Show InChI InChI=1S/C20H21Cl2F2N3O2/c21-15-2-4-18(26-12-15)29-10-7-25-13-20(24)5-8-27(9-6-20)19(28)14-1-3-17(23)16(22)11-14/h1-4,11-12,25H,5-10,13H2
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8.20n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433485
PNG
(US10562853, Compound 10)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-17-3-5-18(6-4-17)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-2-7-20(24)19(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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8.60n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433514
PNG
(US10562853, Compound 35)
Show SMILES Cc1cnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H23ClF2N4O2/c1-14-11-25-19(26-12-14)29-9-6-24-13-20(23)4-7-27(8-5-20)18(28)15-2-3-17(22)16(21)10-15/h2-3,10-12,24H,4-9,13H2,1H3
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12n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433537
PNG
(US10562853, Compound 60)
Show SMILES CC1(C)Cc2cccc(OCCNCC3(F)CCN(CC3)C(=O)c3ccc(F)c(Cl)c3)c2O1
Show InChI InChI=1S/C25H29ClF2N2O3/c1-24(2)15-18-4-3-5-21(22(18)33-24)32-13-10-29-16-25(28)8-11-30(12-9-25)23(31)17-6-7-20(27)19(26)14-17/h3-7,14,29H,8-13,15-16H2,1-2H3
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25n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433537
PNG
(US10562853, Compound 60)
Show SMILES CC1(C)Cc2cccc(OCCNCC3(F)CCN(CC3)C(=O)c3ccc(F)c(Cl)c3)c2O1
Show InChI InChI=1S/C25H29ClF2N2O3/c1-24(2)15-18-4-3-5-21(22(18)33-24)32-13-10-29-16-25(28)8-11-30(12-9-25)23(31)17-6-7-20(27)19(26)14-17/h3-7,14,29H,8-13,15-16H2,1-2H3
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25n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433513
PNG
(US10562853, Compound 32)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ncccn2)CC1
Show InChI InChI=1S/C19H21ClF2N4O2/c20-15-12-14(2-3-16(15)21)17(27)26-9-4-19(22,5-10-26)13-23-8-11-28-18-24-6-1-7-25-18/h1-3,6-7,12,23H,4-5,8-11,13H2
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32n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433516
PNG
(US10562853, Compound 39)
Show SMILES COc1cccc(SCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O2S/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-20(24)19(23)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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33n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433533
PNG
(US10562853, Compound 54)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCNc2ccccn2)CC1
Show InChI InChI=1S/C20H23ClF2N4O/c21-16-13-15(4-5-17(16)22)19(28)27-11-6-20(23,7-12-27)14-24-9-10-26-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2,(H,25,26)
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40n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433482
PNG
(US10562853, Compound 7)
Show SMILES COc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-19-4-2-3-5-20(19)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-17(23)18(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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46n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM433503
PNG
(US10562853, Compound 21)
Show SMILES Cc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C21H24ClF2N3O2/c1-15-2-5-19(26-13-15)29-11-8-25-14-21(24)6-9-27(10-7-21)20(28)16-3-4-18(23)17(22)12-16/h2-5,12-13,25H,6-11,14H2,1H3
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52n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433505
PNG
(US10562853, Compound 23)
Show SMILES COc1cccnc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-18-3-2-8-26-19(18)30-12-9-25-14-21(24)6-10-27(11-7-21)20(28)15-4-5-17(23)16(22)13-15/h2-5,8,13,25H,6-7,9-12,14H2,1H3
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59n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433480
PNG
(US10562853, Compound 6)
Show SMILES COc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-19-4-2-3-5-20(19)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-18(24)17(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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70n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433492
PNG
(US10562853, Compound 13)
Show SMILES CSc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H25Cl2FN2O2S/c1-30-20-5-3-2-4-19(20)29-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-17(23)18(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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75n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433553
PNG
(US10562853, Compound 73)
Show SMILES Cc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H24ClF2N3O2/c1-15-3-2-4-19(26-15)29-12-9-25-14-21(24)7-10-27(11-8-21)20(28)16-5-6-18(23)17(22)13-16/h2-6,13,25H,7-12,14H2,1H3
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110n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433523
PNG
(US10562853, Compound 44)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3[nH]ccc23)CC1
Show InChI InChI=1S/C23H24ClF2N3O2/c24-18-14-16(4-5-19(18)25)22(30)29-11-7-23(26,8-12-29)15-27-10-13-31-21-3-1-2-20-17(21)6-9-28-20/h1-6,9,14,27-28H,7-8,10-13,15H2
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110n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433554
PNG
(US10562853, Compound 74)
Show SMILES FC1(CNCCOc2ccccn2)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H22Cl2FN3O2/c21-16-5-4-15(13-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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130n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433491
PNG
(US10562853, Compound 12)
Show SMILES CSc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H25ClF2N2O2S/c1-30-20-5-3-2-4-19(20)29-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-18(24)17(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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140n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433499
PNG
(US10562853, Compound 16)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3cccnc23)CC1
Show InChI InChI=1S/C24H24ClF2N3O2/c25-19-15-18(6-7-20(19)26)23(31)30-12-8-24(27,9-13-30)16-28-11-14-32-21-5-1-3-17-4-2-10-29-22(17)21/h1-7,10,15,28H,8-9,11-14,16H2
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170n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433501
PNG
(US10562853, Compound 18)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccn2)CC1
Show InChI InChI=1S/C20H22ClF2N3O2/c21-16-13-15(4-5-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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170n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433552
PNG
(US10562853, Compound 72)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(Cl)n2)CC1
Show InChI InChI=1S/C20H21Cl2F2N3O2/c21-15-12-14(4-5-16(15)23)19(28)27-9-6-20(24,7-10-27)13-25-8-11-29-18-3-1-2-17(22)26-18/h1-5,12,25H,6-11,13H2
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180n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433494
PNG
(US10562853, Compound 14)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3OCCOc23)CC1
Show InChI InChI=1S/C23H25ClF2N2O4/c24-17-14-16(4-5-18(17)25)22(29)28-9-6-23(26,7-10-28)15-27-8-11-30-19-2-1-3-20-21(19)32-13-12-31-20/h1-5,14,27H,6-13,15H2
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190n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433495
PNG
(US10562853, Compound 15)
Show SMILES FC1(CNCCOc2cccc3OCCOc23)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H25Cl2FN2O4/c24-17-5-4-16(14-18(17)25)22(29)28-9-6-23(26,7-10-28)15-27-8-11-30-19-2-1-3-20-21(19)32-13-12-31-20/h1-5,14,27H,6-13,15H2
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190n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433534
PNG
(US10562853, Compound 55)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCCc2ccccn2)CC1
Show InChI InChI=1S/C21H24ClF2N3O/c22-18-14-16(6-7-19(18)23)20(28)27-12-8-21(24,9-13-27)15-25-10-3-5-17-4-1-2-11-26-17/h1-2,4,6-7,11,14,25H,3,5,8-10,12-13,15H2
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200n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433500
PNG
(US10562853, Compound 17)
Show SMILES FC1(CNCCOc2cccc3cccnc23)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H24Cl2FN3O2/c25-19-7-6-18(15-20(19)26)23(31)30-12-8-24(27,9-13-30)16-28-11-14-32-21-5-1-3-17-4-2-10-29-22(17)21/h1-7,10,15,28H,8-9,11-14,16H2
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230n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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240n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433507
PNG
(US10562853, Compound 25)
Show SMILES Fc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-15-12-14(4-5-16(15)22)19(28)27-9-6-20(24,7-10-27)13-25-8-11-29-18-3-1-2-17(23)26-18/h1-5,12,25H,6-11,13H2
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270n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433511
PNG
(US10562853, Compound 30)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)-n2cccn2)CC1
Show InChI InChI=1S/C23H24ClF2N5O2/c24-18-15-17(5-6-19(18)25)22(32)30-12-7-23(26,8-13-30)16-27-10-14-33-21-4-1-3-20(29-21)31-11-2-9-28-31/h1-6,9,11,15,27H,7-8,10,12-14,16H2
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290n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433509
PNG
(US10562853, Compound 27)
Show SMILES CN(C)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C22H27ClF2N4O2/c1-28(2)19-4-3-5-20(27-19)31-13-10-26-15-22(25)8-11-29(12-9-22)21(30)16-6-7-18(24)17(23)14-16/h3-7,14,26H,8-13,15H2,1-2H3
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300n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433508
PNG
(US10562853, Compound 26)
Show SMILES CNc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H25ClF2N4O2/c1-25-18-3-2-4-19(27-18)30-12-9-26-14-21(24)7-10-28(11-8-21)20(29)15-5-6-17(23)16(22)13-15/h2-6,13,26H,7-12,14H2,1H3,(H,25,27)
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320n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433474
PNG
(US10562853, Compound 1)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2)CC1
Show InChI InChI=1S/C21H23ClF2N2O2/c22-18-14-16(6-7-19(18)23)20(27)26-11-8-21(24,9-12-26)15-25-10-13-28-17-4-2-1-3-5-17/h1-7,14,25H,8-13,15H2
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380n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433545
PNG
(US10562853, Compound 67)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-16-3-5-19(26-13-16)30-11-8-25-14-21(24)6-9-27(10-7-21)20(28)15-2-4-18(23)17(22)12-15/h2-5,12-13,25H,6-11,14H2,1H3
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400n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433482
PNG
(US10562853, Compound 7)
Show SMILES COc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-19-4-2-3-5-20(19)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-17(23)18(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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450n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433480
PNG
(US10562853, Compound 6)
Show SMILES COc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-19-4-2-3-5-20(19)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-18(24)17(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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570n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433510
PNG
(US10562853, Compound 29)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)N2CCCC2)CC1
Show InChI InChI=1S/C24H29ClF2N4O2/c25-19-16-18(6-7-20(19)26)23(32)31-13-8-24(27,9-14-31)17-28-10-15-33-22-5-3-4-21(29-22)30-11-1-2-12-30/h3-7,16,28H,1-2,8-15,17H2
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630n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433500
PNG
(US10562853, Compound 17)
Show SMILES FC1(CNCCOc2cccc3cccnc23)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H24Cl2FN3O2/c25-19-7-6-18(15-20(19)26)23(31)30-12-8-24(27,9-13-30)16-28-11-14-32-21-5-1-3-17-4-2-10-29-22(17)21/h1-7,10,15,28H,8-9,11-14,16H2
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640n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433492
PNG
(US10562853, Compound 13)
Show SMILES CSc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H25Cl2FN2O2S/c1-30-20-5-3-2-4-19(20)29-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-17(23)18(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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670n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433505
PNG
(US10562853, Compound 23)
Show SMILES COc1cccnc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-18-3-2-8-26-19(18)30-12-9-25-14-21(24)6-10-27(11-7-21)20(28)15-4-5-17(23)16(22)13-15/h2-5,8,13,25H,6-7,9-12,14H2,1H3
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680n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433546
PNG
(US10562853, Compound 68)
Show SMILES COc1ccnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-16-4-7-26-19(13-16)30-11-8-25-14-21(24)5-9-27(10-6-21)20(28)15-2-3-18(23)17(22)12-15/h2-4,7,12-13,25H,5-6,8-11,14H2,1H3
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770n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433508
PNG
(US10562853, Compound 26)
Show SMILES CNc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H25ClF2N4O2/c1-25-18-3-2-4-19(27-18)30-12-9-26-14-21(24)7-10-28(11-8-21)20(29)15-5-6-17(23)16(22)13-15/h2-6,13,26H,7-12,14H2,1H3,(H,25,27)
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850n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433528
PNG
(US10562853, Compound 51)
Show SMILES CNc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H26ClF2N3O2/c1-26-19-4-2-3-5-20(19)30-13-10-27-15-22(25)8-11-28(12-9-22)21(29)16-6-7-18(24)17(23)14-16/h2-7,14,26-27H,8-13,15H2,1H3
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900n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433549
PNG
(US10562853, Compound 70)
Show SMILES Fc1ccnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-16-11-14(1-2-17(16)23)19(28)27-8-4-20(24,5-9-27)13-25-7-10-29-18-12-15(22)3-6-26-18/h1-3,6,11-12,25H,4-5,7-10,13H2
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900n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433476
PNG
(US10562853, Compound 2)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C23H26ClF2N3O3/c1-16(30)28-18-3-2-4-19(14-18)32-12-9-27-15-23(26)7-10-29(11-8-23)22(31)17-5-6-21(25)20(24)13-17/h2-6,13-14,27H,7-12,15H2,1H3,(H,28,30)
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433478
PNG
(US10562853, Compound 4)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(Cl)c2)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-2-1-3-17(13-16)29-11-8-26-14-21(25)6-9-27(10-7-21)20(28)15-4-5-19(24)18(23)12-15/h1-5,12-13,26H,6-11,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433485
PNG
(US10562853, Compound 10)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-17-3-5-18(6-4-17)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-2-7-20(24)19(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433503
PNG
(US10562853, Compound 21)
Show SMILES Cc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C21H24ClF2N3O2/c1-15-2-5-19(26-13-15)29-11-8-25-14-21(24)6-9-27(10-7-21)20(28)16-3-4-18(23)17(22)12-16/h2-5,12-13,25H,6-11,14H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433506
PNG
(US10562853, Compound 24)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cc(ccn2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H21ClF5N3O2/c22-16-11-14(1-2-17(16)23)19(31)30-8-4-20(24,5-9-30)13-28-7-10-32-18-12-15(3-6-29-18)21(25,26)27/h1-3,6,11-12,28H,4-5,7-10,13H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433524
PNG
(US10562853, Compound 45)
Show SMILES CN(C)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C23H28ClF2N3O2/c1-28(2)18-4-3-5-19(15-18)31-13-10-27-16-23(26)8-11-29(12-9-23)22(30)17-6-7-21(25)20(24)14-17/h3-7,14-15,27H,8-13,16H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433526
PNG
(US10562853, Compound 47)
Show SMILES NC(=O)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H24ClF2N3O3/c23-18-13-16(4-5-19(18)24)21(30)28-9-6-22(25,7-10-28)14-27-8-11-31-17-3-1-2-15(12-17)20(26)29/h1-5,12-13,27H,6-11,14H2,(H2,26,29)
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433532
PNG
(US10562853, Compound 53)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCNc2ccccc2)CC1
Show InChI InChI=1S/C21H24ClF2N3O/c22-18-14-16(6-7-19(18)23)20(28)27-12-8-21(24,9-13-27)15-25-10-11-26-17-4-2-1-3-5-17/h1-7,14,25-26H,8-13,15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433538
PNG
(US10562853, Compound 61)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2F)CC1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-16-13-15(5-6-17(16)23)20(28)27-10-7-21(25,8-11-27)14-26-9-12-29-19-4-2-1-3-18(19)24/h1-6,13,26H,7-12,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433546
PNG
(US10562853, Compound 68)
Show SMILES COc1ccnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-16-4-7-26-19(13-16)30-11-8-25-14-21(24)5-9-27(10-6-21)20(28)15-2-3-18(23)17(22)12-15/h2-4,7,12-13,25H,5-6,8-11,14H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433548
PNG
(US10562853, Compound 69)
Show SMILES Fc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-16-11-14(1-3-17(16)23)19(28)27-8-5-20(24,6-9-27)13-25-7-10-29-18-4-2-15(22)12-26-18/h1-4,11-12,25H,5-10,13H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50328639
PNG
((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Show SMILES Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H22ClF2N3O/c1-14-2-4-16(25-11-14)12-24-13-20(23)6-8-26(9-7-20)19(27)15-3-5-18(22)17(21)10-15/h2-5,10-11,24H,6-9,12-13H2,1H3
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US Patent
>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433494
PNG
(US10562853, Compound 14)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3OCCOc23)CC1
Show InChI InChI=1S/C23H25ClF2N2O4/c24-17-14-16(4-5-18(17)25)22(29)28-9-6-23(26,7-10-28)15-27-8-11-30-19-2-1-3-20-21(19)32-13-12-31-20/h1-5,14,27H,6-13,15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433502
PNG
(US10562853, Compound 19)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccnc2)CC1
Show InChI InChI=1S/C20H22ClF2N3O2/c21-17-12-15(3-4-18(17)22)19(27)26-9-5-20(23,6-10-26)14-25-8-11-28-16-2-1-7-24-13-16/h1-4,7,12-13,25H,5-6,8-11,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433516
PNG
(US10562853, Compound 39)
Show SMILES COc1cccc(SCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O2S/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-20(24)19(23)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433523
PNG
(US10562853, Compound 44)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3[nH]ccc23)CC1
Show InChI InChI=1S/C23H24ClF2N3O2/c24-18-14-16(4-5-19(18)25)22(30)29-11-7-23(26,8-12-29)15-27-10-13-31-21-3-1-2-20-17(21)6-9-28-20/h1-6,9,14,27-28H,7-8,10-13,15H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433525
PNG
(US10562853, Compound 46)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C22H22ClF5N2O2/c23-18-12-15(4-5-19(18)24)20(31)30-9-6-21(25,7-10-30)14-29-8-11-32-17-3-1-2-16(13-17)22(26,27)28/h1-5,12-13,29H,6-11,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433542
PNG
(US10562853, Compound 64)
Show SMILES Fc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-18-13-15(1-6-19(18)24)20(28)27-10-7-21(25,8-11-27)14-26-9-12-29-17-4-2-16(23)3-5-17/h1-6,13,26H,7-12,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433485
PNG
(US10562853, Compound 10)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-17-3-5-18(6-4-17)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-2-7-20(24)19(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433495
PNG
(US10562853, Compound 15)
Show SMILES FC1(CNCCOc2cccc3OCCOc23)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H25Cl2FN2O4/c24-17-5-4-16(14-18(17)25)22(29)28-9-6-23(26,7-10-28)15-27-8-11-30-19-2-1-3-20-21(19)32-13-12-31-20/h1-5,14,27H,6-13,15H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433513
PNG
(US10562853, Compound 32)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ncccn2)CC1
Show InChI InChI=1S/C19H21ClF2N4O2/c20-15-12-14(2-3-16(15)21)17(27)26-9-4-19(22,5-10-26)13-23-8-11-28-18-24-6-1-7-25-18/h1-3,6-7,12,23H,4-5,8-11,13H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433515
PNG
(US10562853, Compound 36)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cnccn2)CC1
Show InChI InChI=1S/C19H21ClF2N4O2/c20-15-11-14(1-2-16(15)21)18(27)26-8-3-19(22,4-9-26)13-24-7-10-28-17-12-23-5-6-25-17/h1-2,5-6,11-12,24H,3-4,7-10,13H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433515
PNG
(US10562853, Compound 36)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cnccn2)CC1
Show InChI InChI=1S/C19H21ClF2N4O2/c20-15-11-14(1-2-16(15)21)18(27)26-8-3-19(22,4-9-26)13-24-7-10-28-17-12-23-5-6-25-17/h1-2,5-6,11-12,24H,3-4,7-10,13H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433527
PNG
(US10562853, Compound 48)
Show SMILES NC(=O)c1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H24ClF2N3O3/c23-17-13-15(5-6-18(17)24)21(30)28-10-7-22(25,8-11-28)14-27-9-12-31-19-4-2-1-3-16(19)20(26)29/h1-6,13,27H,7-12,14H2,(H2,26,29)
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433541
PNG
(US10562853, Compound 63)
Show SMILES Cc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O2/c1-16-3-2-4-18(13-16)29-12-9-26-15-22(25)7-10-27(11-8-22)21(28)17-5-6-20(24)19(23)14-17/h2-6,13-14,26H,7-12,15H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433542
PNG
(US10562853, Compound 64)
Show SMILES Fc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-18-13-15(1-6-19(18)24)20(28)27-10-7-21(25,8-11-27)14-26-9-12-29-17-4-2-16(23)3-5-17/h1-6,13,26H,7-12,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433543
PNG
(US10562853, Compound 65)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-2-4-17(5-3-16)29-12-9-26-14-21(25)7-10-27(11-8-21)20(28)15-1-6-19(24)18(23)13-15/h1-6,13,26H,7-12,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433545
PNG
(US10562853, Compound 67)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-16-3-5-19(26-13-16)30-11-8-25-14-21(24)6-9-27(10-7-21)20(28)15-2-4-18(23)17(22)12-15/h2-5,12-13,25H,6-11,14H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433474
PNG
(US10562853, Compound 1)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2)CC1
Show InChI InChI=1S/C21H23ClF2N2O2/c22-18-14-16(6-7-19(18)23)20(27)26-11-8-21(24,9-12-26)15-25-10-13-28-17-4-2-1-3-5-17/h1-7,14,25H,8-13,15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433483
PNG
(US10562853, Compound 8)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-20(24)19(23)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433486
PNG
(US10562853, Compound 11)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-17-3-5-18(6-4-17)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-2-7-19(23)20(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433514
PNG
(US10562853, Compound 35)
Show SMILES Cc1cnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H23ClF2N4O2/c1-14-11-25-19(26-12-14)29-9-6-24-13-20(23)4-7-27(8-5-20)18(28)15-2-3-17(22)16(21)10-15/h2-3,10-12,24H,4-9,13H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433526
PNG
(US10562853, Compound 47)
Show SMILES NC(=O)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H24ClF2N3O3/c23-18-13-16(4-5-19(18)24)21(30)28-9-6-22(25,7-10-28)14-27-8-11-31-17-3-1-2-15(12-17)20(26)29/h1-5,12-13,27H,6-11,14H2,(H2,26,29)
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433527
PNG
(US10562853, Compound 48)
Show SMILES NC(=O)c1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H24ClF2N3O3/c23-17-13-15(5-6-18(17)24)21(30)28-10-7-22(25,8-11-28)14-27-9-12-31-19-4-2-1-3-16(19)20(26)29/h1-6,13,27H,7-12,14H2,(H2,26,29)
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433531
PNG
(US10562853, Compound 52)
Show SMILES CNc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H26ClF2N3O2/c1-26-17-3-2-4-18(14-17)30-12-9-27-15-22(25)7-10-28(11-8-22)21(29)16-5-6-20(24)19(23)13-16/h2-6,13-14,26-27H,7-12,15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433539
PNG
(US10562853, Compound 62)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2Cl)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-3-1-2-4-19(16)29-12-9-26-14-21(25)7-10-27(11-8-21)20(28)15-5-6-18(24)17(23)13-15/h1-6,13,26H,7-12,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433544
PNG
(US10562853, Compound 66)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-18-3-2-4-19(26-18)30-12-9-25-14-21(24)7-10-27(11-8-21)20(28)15-5-6-17(23)16(22)13-15/h2-6,13,25H,7-12,14H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433548
PNG
(US10562853, Compound 69)
Show SMILES Fc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-16-11-14(1-3-17(16)23)19(28)27-8-5-20(24,6-9-27)13-25-7-10-29-18-4-2-15(22)12-26-18/h1-4,11-12,25H,5-10,13H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433554
PNG
(US10562853, Compound 74)
Show SMILES FC1(CNCCOc2ccccn2)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H22Cl2FN3O2/c21-16-5-4-15(13-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433499
PNG
(US10562853, Compound 16)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3cccnc23)CC1
Show InChI InChI=1S/C24H24ClF2N3O2/c25-19-15-18(6-7-20(19)26)23(31)30-12-8-24(27,9-13-30)16-28-11-14-32-21-5-1-3-17-4-2-10-29-22(17)21/h1-7,10,15,28H,8-9,11-14,16H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433502
PNG
(US10562853, Compound 19)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccnc2)CC1
Show InChI InChI=1S/C20H22ClF2N3O2/c21-17-12-15(3-4-18(17)22)19(27)26-9-5-20(23,6-10-26)14-25-8-11-28-16-2-1-7-24-13-16/h1-4,7,12-13,25H,5-6,8-11,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433504
PNG
(US10562853, Compound 22)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccc(Cl)cn2)CC1
Show InChI InChI=1S/C20H21Cl2F2N3O2/c21-15-2-4-18(26-12-15)29-10-7-25-13-20(24)5-8-27(9-6-20)19(28)14-1-3-17(23)16(22)11-14/h1-4,11-12,25H,5-10,13H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433510
PNG
(US10562853, Compound 29)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)N2CCCC2)CC1
Show InChI InChI=1S/C24H29ClF2N4O2/c25-19-16-18(6-7-20(19)26)23(32)31-13-8-24(27,9-14-31)17-28-10-15-33-22-5-3-4-21(29-22)30-11-1-2-12-30/h3-7,16,28H,1-2,8-15,17H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433513
PNG
(US10562853, Compound 32)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ncccn2)CC1
Show InChI InChI=1S/C19H21ClF2N4O2/c20-15-12-14(2-3-16(15)21)17(27)26-9-4-19(22,5-10-26)13-23-8-11-28-18-24-6-1-7-25-18/h1-3,6-7,12,23H,4-5,8-11,13H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433514
PNG
(US10562853, Compound 35)
Show SMILES Cc1cnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H23ClF2N4O2/c1-14-11-25-19(26-12-14)29-9-6-24-13-20(23)4-7-27(8-5-20)18(28)15-2-3-17(22)16(21)10-15/h2-3,10-12,24H,4-9,13H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433519
PNG
(US10562853, Compound 40)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCSc2ccccn2)CC1
Show InChI InChI=1S/C20H22ClF2N3OS/c21-16-13-15(4-5-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433524
PNG
(US10562853, Compound 45)
Show SMILES CN(C)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C23H28ClF2N3O2/c1-28(2)18-4-3-5-19(15-18)31-13-10-27-16-23(26)8-11-29(12-9-23)22(30)17-6-7-21(25)20(24)14-17/h3-7,14-15,27H,8-13,16H2,1-2H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433528
PNG
(US10562853, Compound 51)
Show SMILES CNc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H26ClF2N3O2/c1-26-19-4-2-3-5-20(19)30-13-10-27-15-22(25)8-11-28(12-9-22)21(29)16-6-7-18(24)17(23)14-16/h2-7,14,26-27H,8-13,15H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433531
PNG
(US10562853, Compound 52)
Show SMILES CNc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H26ClF2N3O2/c1-26-17-3-2-4-18(14-17)30-12-9-27-15-22(25)7-10-28(11-8-22)21(29)16-5-6-20(24)19(23)13-16/h2-6,13-14,26-27H,7-12,15H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433535
PNG
(US10562853, Compound 58)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C22H25ClF2N4O3/c1-15(30)27-19-3-2-4-20(28-19)32-12-9-26-14-22(25)7-10-29(11-8-22)21(31)16-5-6-18(24)17(23)13-16/h2-6,13,26H,7-12,14H2,1H3,(H,27,28,30)
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433536
PNG
(US10562853, Compound 59)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCCc2ccccc2)CC1
Show InChI InChI=1S/C22H25ClF2N2O/c23-19-15-18(8-9-20(19)24)21(28)27-13-10-22(25,11-14-27)16-26-12-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-9,15,26H,4,7,10-14,16H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433552
PNG
(US10562853, Compound 72)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(Cl)n2)CC1
Show InChI InChI=1S/C20H21Cl2F2N3O2/c21-15-12-14(4-5-16(15)23)19(28)27-9-6-20(24,7-10-27)13-25-8-11-29-18-3-1-2-17(22)26-18/h1-5,12,25H,6-11,13H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433553
PNG
(US10562853, Compound 73)
Show SMILES Cc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H24ClF2N3O2/c1-15-3-2-4-19(26-15)29-12-9-25-14-21(24)7-10-27(11-8-21)20(28)16-5-6-18(23)17(22)13-16/h2-6,13,25H,7-12,14H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433478
PNG
(US10562853, Compound 4)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(Cl)c2)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-2-1-3-17(13-16)29-11-8-26-14-21(25)6-9-27(10-7-21)20(28)15-4-5-19(24)18(23)12-15/h1-5,12-13,26H,6-11,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433484
PNG
(US10562853, Compound 9)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-19(23)20(24)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433484
PNG
(US10562853, Compound 9)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-19(23)20(24)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433535
PNG
(US10562853, Compound 58)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C22H25ClF2N4O3/c1-15(30)27-19-3-2-4-20(28-19)32-12-9-26-14-22(25)7-10-29(11-8-22)21(31)16-5-6-18(24)17(23)13-16/h2-6,13,26H,7-12,14H2,1H3,(H,27,28,30)
PDB

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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433538
PNG
(US10562853, Compound 61)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2F)CC1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-16-13-15(5-6-17(16)23)20(28)27-10-7-21(25,8-11-27)14-26-9-12-29-19-4-2-1-3-18(19)24/h1-6,13,26H,7-12,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433539
PNG
(US10562853, Compound 62)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2Cl)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-3-1-2-4-19(16)29-12-9-26-14-21(25)7-10-27(11-8-21)20(28)15-5-6-18(24)17(23)13-15/h1-6,13,26H,7-12,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433544
PNG
(US10562853, Compound 66)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C21H24ClF2N3O3/c1-29-18-3-2-4-19(26-18)30-12-9-25-14-21(24)7-10-27(11-8-21)20(28)15-5-6-17(23)16(22)13-15/h2-6,13,25H,7-12,14H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433551
PNG
(US10562853, Compound 71)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H21ClF5N3O2/c22-15-12-14(4-5-16(15)23)19(31)30-9-6-20(24,7-10-30)13-28-8-11-32-18-3-1-2-17(29-18)21(25,26)27/h1-5,12,28H,6-11,13H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433551
PNG
(US10562853, Compound 71)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H21ClF5N3O2/c22-15-12-14(4-5-16(15)23)19(31)30-9-6-20(24,7-10-30)13-28-8-11-32-18-3-1-2-17(29-18)21(25,26)27/h1-5,12,28H,6-11,13H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM50328639
PNG
((3-Chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl...)
Show SMILES Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C20H22ClF2N3O/c1-14-2-4-16(25-11-14)12-24-13-20(23)6-8-26(9-7-20)19(27)15-3-5-18(22)17(21)10-15/h2-5,10-11,24H,6-9,12-13H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433476
PNG
(US10562853, Compound 2)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C23H26ClF2N3O3/c1-16(30)28-18-3-2-4-19(14-18)32-12-9-27-15-23(26)7-10-29(11-8-23)22(31)17-5-6-21(25)20(24)13-17/h2-6,13-14,27H,7-12,15H2,1H3,(H,28,30)
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433477
PNG
(US10562853, Compound 3)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C23H26Cl2FN3O3/c1-16(30)28-18-3-2-4-19(14-18)32-12-9-27-15-23(26)7-10-29(11-8-23)22(31)17-5-6-20(24)21(25)13-17/h2-6,13-14,27H,7-12,15H2,1H3,(H,28,30)
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433479
PNG
(US10562853, Compound 5)
Show SMILES Fc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-18-12-15(4-5-19(18)24)20(28)27-9-6-21(25,7-10-27)14-26-8-11-29-17-3-1-2-16(23)13-17/h1-5,12-13,26H,6-11,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433483
PNG
(US10562853, Compound 8)
Show SMILES COc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O3/c1-29-17-3-2-4-18(14-17)30-12-9-26-15-22(25)7-10-27(11-8-22)21(28)16-5-6-20(24)19(23)13-16/h2-6,13-14,26H,7-12,15H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433486
PNG
(US10562853, Compound 11)
Show SMILES COc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C22H25Cl2FN2O3/c1-29-17-3-5-18(6-4-17)30-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-2-7-19(23)20(24)14-16/h2-7,14,26H,8-13,15H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433504
PNG
(US10562853, Compound 22)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccc(Cl)cn2)CC1
Show InChI InChI=1S/C20H21Cl2F2N3O2/c21-15-2-4-18(26-12-15)29-10-7-25-13-20(24)5-8-27(9-6-20)19(28)14-1-3-17(23)16(22)11-14/h1-4,11-12,25H,5-10,13H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433506
PNG
(US10562853, Compound 24)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cc(ccn2)C(F)(F)F)CC1
Show InChI InChI=1S/C21H21ClF5N3O2/c22-16-11-14(1-2-17(16)23)19(31)30-8-4-20(24,5-9-30)13-28-7-10-32-18-12-15(3-6-29-18)21(25,26)27/h1-3,6,11-12,28H,4-5,7-10,13H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433507
PNG
(US10562853, Compound 25)
Show SMILES Fc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-15-12-14(4-5-16(15)22)19(28)27-9-6-20(24,7-10-27)13-25-8-11-29-18-3-1-2-17(23)26-18/h1-5,12,25H,6-11,13H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433519
PNG
(US10562853, Compound 40)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCSc2ccccn2)CC1
Show InChI InChI=1S/C20H22ClF2N3OS/c21-16-13-15(4-5-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433525
PNG
(US10562853, Compound 46)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C22H22ClF5N2O2/c23-18-12-15(4-5-19(18)24)20(31)30-9-6-21(25,7-10-30)14-29-8-11-32-17-3-1-2-16(13-17)22(26,27)28/h1-5,12-13,29H,6-11,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433536
PNG
(US10562853, Compound 59)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCCc2ccccc2)CC1
Show InChI InChI=1S/C22H25ClF2N2O/c23-19-15-18(8-9-20(19)24)21(28)27-13-10-22(25,11-14-27)16-26-12-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-9,15,26H,4,7,10-14,16H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433541
PNG
(US10562853, Compound 63)
Show SMILES Cc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H25ClF2N2O2/c1-16-3-2-4-18(13-16)29-12-9-26-15-22(25)7-10-27(11-8-22)21(28)17-5-6-20(24)19(23)14-17/h2-6,13-14,26H,7-12,15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433477
PNG
(US10562853, Compound 3)
Show SMILES CC(=O)Nc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C23H26Cl2FN3O3/c1-16(30)28-18-3-2-4-19(14-18)32-12-9-27-15-23(26)7-10-29(11-8-23)22(31)17-5-6-20(24)21(25)13-17/h2-6,13-14,27H,7-12,15H2,1H3,(H,28,30)
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433479
PNG
(US10562853, Compound 5)
Show SMILES Fc1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C21H22ClF3N2O2/c22-18-12-15(4-5-19(18)24)20(28)27-9-6-21(25,7-10-27)14-26-8-11-29-17-3-1-2-16(23)13-17/h1-5,12-13,26H,6-11,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433491
PNG
(US10562853, Compound 12)
Show SMILES CSc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H25ClF2N2O2S/c1-30-20-5-3-2-4-19(20)29-13-10-26-15-22(25)8-11-27(12-9-22)21(28)16-6-7-18(24)17(23)14-16/h2-7,14,26H,8-13,15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433501
PNG
(US10562853, Compound 18)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccn2)CC1
Show InChI InChI=1S/C20H22ClF2N3O2/c21-16-13-15(4-5-17(16)22)19(27)26-10-6-20(23,7-11-26)14-24-9-12-28-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433503
PNG
(US10562853, Compound 21)
Show SMILES Cc1ccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)nc1
Show InChI InChI=1S/C21H24ClF2N3O2/c1-15-2-5-19(26-13-15)29-11-8-25-14-21(24)6-9-27(10-7-21)20(28)16-3-4-18(23)17(22)12-16/h2-5,12-13,25H,6-11,14H2,1H3
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433509
PNG
(US10562853, Compound 27)
Show SMILES CN(C)c1cccc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)n1
Show InChI InChI=1S/C22H27ClF2N4O2/c1-28(2)19-4-3-5-20(27-19)31-13-10-26-15-22(25)8-11-29(12-9-22)21(30)16-6-7-18(24)17(23)14-16/h3-7,14,26H,8-13,15H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433511
PNG
(US10562853, Compound 30)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc(n2)-n2cccn2)CC1
Show InChI InChI=1S/C23H24ClF2N5O2/c24-18-15-17(5-6-19(18)25)22(32)30-12-7-23(26,8-13-30)16-27-10-14-33-21-4-1-3-20(29-21)31-11-2-9-28-31/h1-6,9,11,15,27H,7-8,10,12-14,16H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433532
PNG
(US10562853, Compound 53)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCNc2ccccc2)CC1
Show InChI InChI=1S/C21H24ClF2N3O/c22-18-14-16(6-7-19(18)23)20(28)27-12-8-21(24,9-13-27)15-25-10-11-26-17-4-2-1-3-5-17/h1-7,14,25-26H,8-13,15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433533
PNG
(US10562853, Compound 54)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCNc2ccccn2)CC1
Show InChI InChI=1S/C20H23ClF2N4O/c21-16-13-15(4-5-17(16)22)19(28)27-11-6-20(23,7-12-27)14-24-9-10-26-18-3-1-2-8-25-18/h1-5,8,13,24H,6-7,9-12,14H2,(H,25,26)
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433534
PNG
(US10562853, Compound 55)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCCc2ccccn2)CC1
Show InChI InChI=1S/C21H24ClF2N3O/c22-18-14-16(6-7-19(18)23)20(28)27-12-8-21(24,9-13-27)15-25-10-3-5-17-4-1-2-11-26-17/h1-2,4,6-7,11,14,25H,3,5,8-10,12-13,15H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM433543
PNG
(US10562853, Compound 65)
Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C21H22Cl2F2N2O2/c22-16-2-4-17(5-3-16)29-12-9-26-14-21(25)7-10-27(11-8-21)20(28)15-1-6-19(24)18(23)13-15/h1-6,13,26H,7-12,14H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM433549
PNG
(US10562853, Compound 70)
Show SMILES Fc1ccnc(OCCNCC2(F)CCN(CC2)C(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C20H21ClF3N3O2/c21-16-11-14(1-2-17(16)23)19(28)27-8-4-20(24,5-9-27)13-25-7-10-29-18-12-15(22)3-6-26-18/h1-3,6,11-12,25H,4-5,7-10,13H2
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NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
Adrenergic receptor


(Homo sapiens (Human))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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>5.00E+3n/an/an/an/an/an/an/an/a



NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent


Assay Description
Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...


US Patent US10562853 (2020)


BindingDB Entry DOI: 10.7270/Q29Z979D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%