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Patent code US10562878

Compile Data Set for Download or QSAR

Found 1149 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Monoamine transporter


(Homo sapiens (Human))		BDBM50337844
PNG
(1-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-4-met...)
Show SMILES CN1CCN(CC2(CCCCC2)c2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C18H26Cl2N2/c1-21-9-11-22(12-10-21)14-18(7-3-2-4-8-18)15-5-6-16(19)17(20)13-15/h5-6,13H,2-4,7-12,14H2,1H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337831
PNG
(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Show SMILES CN(C)CC1(CCCCC1)c1cccc2ccccc12
Show InChI InChI=1S/C19H25N/c1-20(2)15-19(13-6-3-7-14-19)18-12-8-10-16-9-4-5-11-17(16)18/h4-5,8-12H,3,6-7,13-15H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337915
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-3-methy...)
Show SMILES CC(C)CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2N/c1-12(2)10-16(20)17(8-4-3-5-9-17)13-6-7-14(18)15(19)11-13/h6-7,11-12,16H,3-5,8-10,20H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337830
PNG
(CHEMBL1683875 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Show SMILES CCN(C)CC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-3-19(2)12-16(9-5-4-6-10-16)13-7-8-14(17)15(18)11-13/h7-8,11H,3-6,9-10,12H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433711
PNG
(US10562878, Compound 268 | US10562878, Compound 26...)
Show SMILES CNCC1(CCC(F)(F)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H17Cl2F2N/c1-19-9-13(4-6-14(17,18)7-5-13)10-2-3-11(15)12(16)8-10/h2-3,8,19H,4-7,9H2,1H3
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n/an/a<1n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433654
PNG
(US10562878, Compound 115)
Show SMILES CC1CCCN1CC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H25Cl2N/c1-14-6-5-11-21(14)13-18(9-3-2-4-10-18)15-7-8-16(19)17(20)12-15/h7-8,12,14H,2-6,9-11,13H2,1H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433673
PNG
(US10562878, Compound 254 | US10562878, Compound 26...)
Show SMILES CN(C)CC1(CCC(F)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H20Cl2FN/c1-19(2)10-15(7-5-12(18)6-8-15)11-3-4-13(16)14(17)9-11/h3-4,9,12H,5-8,10H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337829
PNG
(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)
Show SMILES CN(C)CC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-18(2)11-15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10H,3-5,8-9,11H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433734
PNG
(US10562878, Compound 206 E1 | US10562878, Compound...)
Show SMILES CN(C)CC1(CCCC(F)(F)C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H19Cl2F2N/c1-20(2)10-14(6-3-7-15(18,19)9-14)11-4-5-12(16)13(17)8-11/h4-5,8H,3,6-7,9-10H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337831
PNG
(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Show SMILES CN(C)CC1(CCCCC1)c1cccc2ccccc12
Show InChI InChI=1S/C19H25N/c1-20(2)15-19(13-6-3-7-14-19)18-12-8-10-16-9-4-5-11-17(16)18/h4-5,8-12H,3,6-7,13-15H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337818
PNG
(CHEMBL1683876 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Show SMILES CCN(CC)CC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2N/c1-3-20(4-2)13-17(10-6-5-7-11-17)14-8-9-15(18)16(19)12-14/h8-9,12H,3-7,10-11,13H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337913
PNG
((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H27N/c1-16(21(2)3)20(13-7-4-8-14-20)19-12-11-17-9-5-6-10-18(17)15-19/h5-6,9-12,15-16H,4,7-8,13-14H2,1-3H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM433905
PNG
(US10562878, Compound 161 E1 | US10562878, Compound...)
Show SMILES CN(C)CC1(CCCCC1O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C16H22F3NO2/c1-20(2)11-15(10-4-3-5-14(15)21)12-6-8-13(9-7-12)22-16(17,18)19/h6-9,14,21H,3-5,10-11H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50149940
PNG
(CHEMBL3770651 | US10562878, Compound 203)
Show SMILES CN(C)CC1(CCCC(O)C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H32ClN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m1/s1
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337823
PNG
(1-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)pyrrol...)
Show SMILES Clc1ccc(cc1Cl)C1(CN2CCCC2)CCCCC1
Show InChI InChI=1S/C17H23Cl2N/c18-15-7-6-14(12-16(15)19)17(8-2-1-3-9-17)13-20-10-4-5-11-20/h6-7,12H,1-5,8-11,13H2
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433675
PNG
(US10562878, Compound 72)
Show SMILES CN(C)CC1(CCC=CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H19Cl2N/c1-18(2)11-15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h3-4,6-7,10H,5,8-9,11H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM433842
PNG
(US10562878, Compound 63 E1 | US10562878, Compound ...)
Show SMILES CC(N(C)C)C1(CCCCC1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C17H24F3NO/c1-13(21(2)3)16(11-5-4-6-12-16)14-7-9-15(10-8-14)22-17(18,19)20/h7-10,13H,4-6,11-12H2,1-3H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM433736
PNG
(US10562878, Compound 147 E1 | US10562878, Compound...)
Show SMILES CN(C)CC1(CCCCC1O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25NO/c1-20(2)14-19(12-6-5-9-18(19)21)17-11-10-15-7-3-4-8-16(15)13-17/h3-4,7-8,10-11,13,18,21H,5-6,9,12,14H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337822
PNG
(4-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)morpho...)
Show SMILES Clc1ccc(cc1Cl)C1(CN2CCOCC2)CCCCC1
Show InChI InChI=1S/C17H23Cl2NO/c18-15-5-4-14(12-16(15)19)17(6-2-1-3-7-17)13-20-8-10-21-11-9-20/h4-5,12H,1-3,6-11,13H2
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337832
PNG
(CHEMBL1683873 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Show SMILES Clc1ccc(cc1Cl)C1(CNC2CC2)CCCCC1
Show InChI InChI=1S/C16H21Cl2N/c17-14-7-4-12(10-15(14)18)16(8-2-1-3-9-16)11-19-13-5-6-13/h4,7,10,13,19H,1-3,5-6,8-9,11H2
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50149940
PNG
(CHEMBL3770651 | US10562878, Compound 203)
Show SMILES CN(C)CC1(CCCC(O)C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H32ClN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m1/s1
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming 1


(Rat)		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
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n/an/a 2.20n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming 1


(Rat)		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 2.30n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming 1


(Rat)		BDBM433673
PNG
(US10562878, Compound 254 | US10562878, Compound 26...)
Show SMILES CN(C)CC1(CCC(F)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H20Cl2FN/c1-19(2)10-15(7-5-12(18)6-8-15)11-3-4-13(16)14(17)9-11/h3-4,9,12H,5-8,10H2,1-2H3
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n/an/a 2.40n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming 1


(Rat)		BDBM433764
PNG
(US10562878, Compound 273 | US10562878, Compound 27...)
Show SMILES CNCC1(CCC(C)(O)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2NO/c1-14(19)5-7-15(8-6-14,10-18-2)11-3-4-12(16)13(17)9-11/h3-4,9,18-19H,5-8,10H2,1-2H3
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n/an/a 2.70n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 2.90n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming 1


(Rat)		BDBM50337831
PNG
(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Show SMILES CN(C)CC1(CCCCC1)c1cccc2ccccc12
Show InChI InChI=1S/C19H25N/c1-20(2)15-19(13-6-3-7-14-19)18-12-8-10-16-9-4-5-11-17(16)18/h4-5,8-12H,3,6-7,13-15H2,1-2H3
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n/an/a 2.90n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337833
PNG
(CHEMBL1683902 | N,N-dimethyl-1-(1-(naphthalen-2-yl...)
Show SMILES CN(C)CC1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-20(2)15-19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14H,3,6-7,12-13,15H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50149940
PNG
(CHEMBL3770651 | US10562878, Compound 203)
Show SMILES CN(C)CC1(CCCC(O)C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H32ClN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433835
PNG
(US10562878, Compound 233 | US10562878, Compound 23...)
Show SMILES CN(C)CC1(CCC(F)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24FN/c1-21(2)14-19(11-9-18(20)10-12-19)17-8-7-15-5-3-4-6-16(15)13-17/h3-8,13,18H,9-12,14H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337833
PNG
(CHEMBL1683902 | N,N-dimethyl-1-(1-(naphthalen-2-yl...)
Show SMILES CN(C)CC1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-20(2)15-19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14H,3,6-7,12-13,15H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433652
PNG
(US10562878, Compound 116)
Show SMILES OC1CCCC1NCC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H25Cl2NO/c19-14-8-7-13(11-15(14)20)18(9-2-1-3-10-18)12-21-16-5-4-6-17(16)22/h7-8,11,16-17,21-22H,1-6,9-10,12H2
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n/an/a 3n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming 1


(Rat)		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 3.60n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)		BDBM50337829
PNG
(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)
Show SMILES CN(C)CC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-18(2)11-15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10H,3-5,8-9,11H2,1-2H3
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n/an/a 4n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433836
PNG
(US10562878, Compound 62 E1 | US10562878, Compound ...)
Show SMILES CCC(NC)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2N/c1-3-15(19-2)16(9-5-4-6-10-16)12-7-8-13(17)14(18)11-12/h7-8,11,15,19H,3-6,9-10H2,1-2H3
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n/an/a 4n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433833
PNG
(US10562878, Compound 293)
Show SMILES CN(C)CC1(CCC=CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H23N/c1-20(2)15-19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h3-6,8-11,14H,7,12-13,15H2,1-2H3
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n/an/a 4n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)		BDBM433566
PNG
(US10562878, Compound 172 E1 | US10562878, Compound...)
Show SMILES CN(C)CC1(CCCCC1CO)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2NO/c1-19(2)11-16(8-4-3-5-13(16)10-20)12-6-7-14(17)15(18)9-12/h6-7,9,13,20H,3-5,8,10-11H2,1-2H3
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n/an/a 4n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337834
PNG
(CHEMBL1683872 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Show SMILES CCNCC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-2-18-11-15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10,18H,2-5,8-9,11H2,1H3
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n/an/a 4n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433911
PNG
(US10562878, Compound 252)
Show SMILES CN(C)CC1(CCC(F)(F)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H23F2N/c1-22(2)14-18(9-11-19(20,21)12-10-18)17-8-7-15-5-3-4-6-16(15)13-17/h3-8,13H,9-12,14H2,1-2H3
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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM50337914
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)propan-1...)
Show SMILES CCC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-2-14(18)15(8-4-3-5-9-15)11-6-7-12(16)13(17)10-11/h6-7,10,14H,2-5,8-9,18H2,1H3
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n/an/a 5n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming 1


(Rat)		BDBM50337910
PNG
((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-11(18-2)15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10-11,18H,3-5,8-9H2,1-2H3
MMDB

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SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming gene 1 protein


(Homo sapiens)		BDBM50337818
PNG
(CHEMBL1683876 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Show SMILES CCN(CC)CC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2N/c1-3-20(4-2)13-17(10-6-5-7-11-17)14-8-9-15(18)16(19)12-14/h8-9,12H,3-7,10-11,13H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))		BDBM50337818
PNG
(CHEMBL1683876 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Show SMILES CCN(CC)CC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2N/c1-3-20(4-2)13-17(10-6-5-7-11-17)14-8-9-15(18)16(19)12-14/h8-9,12H,3-7,10-11,13H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM433715
PNG
(US10562878, Compound cis 125 | US10562878, Compoun...)
Show SMILES COC1CCCCC1(CN(C)C)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H23Cl2NO/c1-19(2)11-16(9-5-4-6-15(16)20-3)12-7-8-13(17)14(18)10-12/h7-8,10,15H,4-6,9,11H2,1-3H3
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n/an/a 6n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50337912
PNG
(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Show SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H25N/c1-15(20-2)19(12-6-3-7-13-19)18-11-10-16-8-4-5-9-17(16)14-18/h4-5,8-11,14-15,20H,3,6-7,12-13H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporter


(Homo sapiens (Human))		BDBM433911
PNG
(US10562878, Compound 252)
Show SMILES CN(C)CC1(CCC(F)(F)CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H23F2N/c1-22(2)14-18(9-11-19(20,21)12-10-18)17-8-7-15-5-3-4-6-16(15)13-17/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Neuroepithelial cell-transforming 1


(Rat)		BDBM50337829
PNG
(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)
Show SMILES CN(C)CC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H21Cl2N/c1-18(2)11-15(8-4-3-5-9-15)12-6-7-13(16)14(17)10-12/h6-7,10H,3-5,8-9,11H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine


(Rattus norvegicus (rat))		BDBM50337831
PNG
(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Show SMILES CN(C)CC1(CCCCC1)c1cccc2ccccc12
Show InChI InChI=1S/C19H25N/c1-20(2)15-19(13-6-3-7-14-19)18-12-8-10-16-9-4-5-11-17(16)18/h4-5,8-12H,3,6-7,13-15H2,1-2H3
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n/an/a 6.10n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))		BDBM50337831
PNG
(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Show SMILES CN(C)CC1(CCCCC1)c1cccc2ccccc12
Show InChI InChI=1S/C19H25N/c1-20(2)15-19(13-6-3-7-14-19)18-12-8-10-16-9-4-5-11-17(16)18/h4-5,8-12H,3,6-7,13-15H2,1-2H3
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n/an/a 6.5n/an/an/an/an/an/a



SUNOVION PHARAMCEUTICALS INC.

US Patent


Assay Description
Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...

US Patent US10562878 (2020)


BindingDB Entry DOI: 10.7270/Q2XP77BX
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%