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Patent code US10562890

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434071
PNG
(US10562890, Compound Al-12-16)
Show SMILES COc1cnc(-c2nc3cc(OC(F)(F)F)ccc3[nH]2)c(OC)c1
Show InChI InChI=1S/C15H12F3N3O3/c1-22-9-6-12(23-2)13(19-7-9)14-20-10-4-3-8(5-11(10)21-14)24-15(16,17)18/h3-7H,1-2H3,(H,20,21)
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n/an/a 1.69E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434079
PNG
(US10562890, Compound Al-14-72)
Show SMILES COc1ccnc(-c2nc3cc(OC(F)(F)F)ccc3[nH]2)c1OC
Show InChI InChI=1S/C15H12F3N3O3/c1-22-11-5-6-19-12(13(11)23-2)14-20-9-4-3-8(7-10(9)21-14)24-15(16,17)18/h3-7H,1-2H3,(H,20,21)
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n/an/a 1.72E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434076
PNG
(US10562890, Compound Al-14-100)
Show SMILES COc1cc(OCCN2CCN(Cc3ccccc3)CC2)cnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C27H28F3N5O3/c1-36-24-16-21(37-14-13-34-9-11-35(12-10-34)18-19-5-3-2-4-6-19)17-31-25(24)26-32-22-8-7-20(15-23(22)33-26)38-27(28,29)30/h2-8,15-17H,9-14,18H2,1H3,(H,32,33)
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n/an/a 2.16E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434070
PNG
(US10562890, Compound Al-10-104)
Show SMILES OCc1cccnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C14H10F3N3O2/c15-14(16,17)22-9-3-4-10-11(6-9)20-13(19-10)12-8(7-21)2-1-5-18-12/h1-6,21H,7H2,(H,19,20)
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n/an/a 2.65E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434075
PNG
(US10562890, Compound Al-14-95)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(nc2c1)-c1ccc(OCCN2CCN(Cc3ccccc3)CC2)cn1
Show InChI InChI=1S/C26H26F3N5O2/c27-26(28,29)36-20-6-8-22-24(16-20)32-25(31-22)23-9-7-21(17-30-23)35-15-14-33-10-12-34(13-11-33)18-19-4-2-1-3-5-19/h1-9,16-17H,10-15,18H2,(H,31,32)
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n/an/a 2.65E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434074
PNG
(US10562890, Compound Al-14-91)
Show SMILES OCc1cc(OCCN2CCOCC2)cnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C20H21F3N4O4/c21-20(22,23)31-14-1-2-16-17(10-14)26-19(25-16)18-13(12-28)9-15(11-24-18)30-8-5-27-3-6-29-7-4-27/h1-2,9-11,28H,3-8,12H2,(H,25,26)
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n/an/a 2.97E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434069
PNG
(US10562890, Compound Al-10-47)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C13H8F3N3O/c14-13(15,16)20-8-4-5-9-11(7-8)19-12(18-9)10-3-1-2-6-17-10/h1-7H,(H,18,19)
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n/an/a 3.19E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434072
PNG
(US10562890, Compound Al-14-55)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(nc2c1)-c1ncccc1OCCN1CCOCC1
Show InChI InChI=1S/C19H19F3N4O3/c20-19(21,22)29-13-3-4-14-15(12-13)25-18(24-14)17-16(2-1-5-23-17)28-11-8-26-6-9-27-10-7-26/h1-5,12H,6-11H2,(H,24,25)
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n/an/a 4.83E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434078
PNG
(US10562890, Compound Al-14-18)
Show SMILES CN(C)c1cccnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C15H13F3N4O/c1-22(2)12-4-3-7-19-13(12)14-20-10-6-5-9(8-11(10)21-14)23-15(16,17)18/h3-8H,1-2H3,(H,20,21)
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n/an/a 4.97E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434073
PNG
(US10562890, Compound Al-12-126)
Show SMILES FC(F)(F)Oc1ccc2[nH]c(nc2c1)-c1ccc(OCCN2CCOCC2)cn1
Show InChI InChI=1S/C19H19F3N4O3/c20-19(21,22)29-13-1-3-15-17(11-13)25-18(24-15)16-4-2-14(12-23-16)28-10-7-26-5-8-27-9-6-26/h1-4,11-12H,5-10H2,(H,24,25)
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n/an/a 8.91E+3n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434065
PNG
(US10562890, Compound Al-4-57)
Show SMILES COc1ccc2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3O/c1-17-9-5-6-10-12(8-9)16-13(15-10)11-4-2-3-7-14-11/h2-8H,1H3,(H,15,16)
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n/an/a 3.43E+4n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM123656
PNG
(US10562890, Compound 4a | US8748618, AI-4-52)
Show SMILES COc1cccc2[nH]c(nc12)-c1ccccn1
Show InChI InChI=1S/C13H11N3O/c1-17-11-7-4-6-9-12(11)16-13(15-9)10-5-2-3-8-14-10/h2-8H,1H3,(H,15,16)
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US Patent
n/an/a>3.43E+4n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434065
PNG
(US10562890, Compound Al-4-57)
Show SMILES COc1ccc2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3O/c1-17-9-5-6-10-12(8-9)16-13(15-10)11-4-2-3-7-14-11/h2-8H,1H3,(H,15,16)
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n/an/a 3.43E+4n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434067
PNG
(US10562890, Compound 3c)
Show SMILES Fc1ccc2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C12H8FN3/c13-8-4-5-9-11(7-8)16-12(15-9)10-3-1-2-6-14-10/h1-7H,(H,15,16)
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n/an/a>3.43E+4n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434066
PNG
(US10562890, Compound 3b)
Show SMILES CCOc1ccc2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C14H13N3O/c1-2-18-10-6-7-11-13(9-10)17-14(16-11)12-5-3-4-8-15-12/h3-9H,2H2,1H3,(H,16,17)
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n/an/a>3.43E+4n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM434077
PNG
(US10562890, Compound Al-12-150)
Show SMILES OC(=O)c1cccnc1-c1nc2cc(OC(F)(F)F)ccc2[nH]1
Show InChI InChI=1S/C14H8F3N3O3/c15-14(16,17)23-7-3-4-9-10(6-7)20-12(19-9)11-8(13(21)22)2-1-5-18-11/h1-6H,(H,19,20)(H,21,22)
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n/an/a 4.89E+4n/an/an/an/an/an/a



UNIVERSITY OF VIRGINIA PATENT FOUNDATION

US Patent


Assay Description
FRET assay can be used to effectively monitor the inhibition of CBF binding to the Runt domain of RUNX proteins (as well as for CBFβ-SMMHC bindi...


US Patent US10562890 (2020)


BindingDB Entry DOI: 10.7270/Q2DR2XWH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%