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Patent code US10562891

Compile Data Set for Download or QSAR

Found 435 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434098
PNG
(US10562891, Example 20)
Show SMILES Cc1cccc2c1nc(CSC1CCCNCC1)[nH]c2=O
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434136
PNG
(US10562891, Example 58)
Show SMILES Cc1ccc(F)c2c1nc(CS[C@@H]1CC[C@H](O)CC1)[nH]c2=O
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434139
PNG
(US10562891, Example 61)
Show SMILES Cc1ccc(c2c1nc(CS[C@@H]1CC[C@H](O)CC1)[nH]c2=O)C(F)(F)F
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434179
PNG
(US10562891, Example 101)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(Nc3cccnc3)ccc2c(=O)[nH]1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434217
PNG
(US10562891, Example 139)
Show SMILES CC(=O)Nc1ccc(CN2CCC(CC2)SCc2nc3c(C)cccc3c(=O)[nH]2)cc1
Show InChI InChI=1S/C24H28N4O2S/c1-16-4-3-5-21-23(16)26-22(27-24(21)30)15-31-20-10-12-28(13-11-20)14-18-6-8-19(9-7-18)25-17(2)29/h3-9,20H,10-15H2,1-2H3,(H,25,29)(H,26,27,30)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434230
PNG
(US10562891, Example 152)
Show SMILES Cc1cccc2c1nc(CSC1CCN(Cc3cnc4ccccn34)CC1)[nH]c2=O
Show InChI InChI=1S/C23H25N5OS/c1-16-5-4-6-19-22(16)25-20(26-23(19)29)15-30-18-8-11-27(12-9-18)14-17-13-24-21-7-2-3-10-28(17)21/h2-7,10,13,18H,8-9,11-12,14-15H2,1H3,(H,25,26,29)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434231
PNG
(US10562891, Example 153)
Show SMILES Cc1cccc2c1nc(CSC1CCN(Cc3cncn3Cc3ccccc3)CC1)[nH]c2=O
Show InChI InChI=1S/C26H29N5OS/c1-19-6-5-9-23-25(19)28-24(29-26(23)32)17-33-22-10-12-30(13-11-22)16-21-14-27-18-31(21)15-20-7-3-2-4-8-20/h2-9,14,18,22H,10-13,15-17H2,1H3,(H,28,29,32)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434232
PNG
(US10562891, Example 154)
Show SMILES Cc1cccc2c1nc(CSC1CCN(Cc3cnn(Cc4ccccc4)c3)CC1)[nH]c2=O
Show InChI InChI=1S/C26H29N5OS/c1-19-6-5-9-23-25(19)28-24(29-26(23)32)18-33-22-10-12-30(13-11-22)15-21-14-27-31(17-21)16-20-7-3-2-4-8-20/h2-9,14,17,22H,10-13,15-16,18H2,1H3,(H,28,29,32)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434243
PNG
(US10562891, Example 165)
Show SMILES Cc1cccc2c1nc(CSC1CCN(CCCN)CC1)[nH]c2=O
Show InChI InChI=1S/C18H26N4OS/c1-13-4-2-5-15-17(13)20-16(21-18(15)23)12-24-14-6-10-22(11-7-14)9-3-8-19/h2,4-5,14H,3,6-12,19H2,1H3,(H,20,21,23)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434248
PNG
(US10562891, Example 170)
Show SMILES Cc1cccc2c1nc(CSC1CCN(CC1)C(=O)[C@@H](N)CCCNC(N)=N)[nH]c2=O
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434264
PNG
(US10562891, Example 186)
Show SMILES O=c1[nH]c(CSC2CCOCC2)nc2nc(NC3CCCC3)ccc12
Show InChI InChI=1S/C18H24N4O2S/c23-18-14-5-6-15(19-12-3-1-2-4-12)20-17(14)21-16(22-18)11-25-13-7-9-24-10-8-13/h5-6,12-13H,1-4,7-11H2,(H2,19,20,21,22,23)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434295
PNG
(US10562891, Example 215)
Show SMILES Fc1cc(NC2CCCC2)cc2nc(CSC3CCCCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H26FN3OS/c21-16-10-14(22-13-6-4-5-7-13)11-17-19(16)20(25)24-18(23-17)12-26-15-8-2-1-3-9-15/h10-11,13,15,22H,1-9,12H2,(H,23,24,25)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434299
PNG
(US10562891, Example 219)
Show SMILES O=c1[nH]c(CSC2CCOCC2)nc2cc(OCC3CC3)ccc12
Show InChI InChI=1S/C18H22N2O3S/c21-18-15-4-3-13(23-10-12-1-2-12)9-16(15)19-17(20-18)11-24-14-5-7-22-8-6-14/h3-4,9,12,14H,1-2,5-8,10-11H2,(H,19,20,21)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434303
PNG
(US10562891, Example 223)
Show SMILES F[C@@H]1CNC[C@@H]1SCc1nc2cc(NC3CCCC3)cc(F)c2c(=O)[nH]1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434306
PNG
(US10562891, Example 226)
Show SMILES Fc1cc2c(cc1NC1CCCC1)nc(CSC1CCNCC1)[nH]c2=O
Show InChI InChI=1S/C19H25FN4OS/c20-15-9-14-16(10-17(15)22-12-3-1-2-4-12)23-18(24-19(14)25)11-26-13-5-7-21-8-6-13/h9-10,12-13,21-22H,1-8,11H2,(H,23,24,25)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434309
PNG
(US10562891, Example 229)
Show SMILES O=c1[nH]c(CSC2CCNCC2)nc2nc(OCC3CC3)ccc12
Show InChI InChI=1S/C17H22N4O2S/c22-17-13-3-4-15(23-9-11-1-2-11)21-16(13)19-14(20-17)10-24-12-5-7-18-8-6-12/h3-4,11-12,18H,1-2,5-10H2,(H,19,20,21,22)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434311
PNG
(US10562891, Example 231)
Show SMILES Fc1cc(NC2CCCC2(F)F)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434316
PNG
(US10562891, Example 236)
Show SMILES Fc1cc(OCC2CCOCC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H25FN2O4S/c21-16-9-14(27-11-13-1-5-25-6-2-13)10-17-19(16)20(24)23-18(22-17)12-28-15-3-7-26-8-4-15/h9-10,13,15H,1-8,11-12H2,(H,22,23,24)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434317
PNG
(US10562891, Example 237)
Show SMILES Cc1cc(OCC2CCC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H26N2O3S/c1-13-9-15(25-11-14-3-2-4-14)10-17-19(13)20(23)22-18(21-17)12-26-16-5-7-24-8-6-16/h9-10,14,16H,2-8,11-12H2,1H3,(H,21,22,23)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434322
PNG
(US10562891, Example 241)
Show SMILES F[C@@H]1CNCC[C@@H](C1)SCc1nc2cc(NC3CCCC3)cc(F)c2c(=O)[nH]1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434328
PNG
(US10562891, Example 247)
Show SMILES Fc1cc(NC2CCCCC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H26FN3O2S/c21-16-10-14(22-13-4-2-1-3-5-13)11-17-19(16)20(25)24-18(23-17)12-27-15-6-8-26-9-7-15/h10-11,13,15,22H,1-9,12H2,(H,23,24,25)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434331
PNG
(US10562891, Example 250)
Show SMILES CS(=O)(=O)N1CCC[C@H](C1)Nc1cc(F)c2c(c1)nc(CSC1CCOCC1)[nH]c2=O
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434333
PNG
(US10562891, Example 252)
Show SMILES O=c1[nH]c(CSC2CCOCC2)nc2cc(NCCC3CCCC3)ccc12
Show InChI InChI=1S/C21H29N3O2S/c25-21-18-6-5-16(22-10-7-15-3-1-2-4-15)13-19(18)23-20(24-21)14-27-17-8-11-26-12-9-17/h5-6,13,15,17,22H,1-4,7-12,14H2,(H,23,24,25)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434336
PNG
(US10562891, Example 255)
Show SMILES Fc1cc(NC2CCCC2)cc2nc(CSC3CCN(CC3)C3COC3)[nH]c(=O)c12
Show InChI InChI=1S/C22H29FN4O2S/c23-18-9-15(24-14-3-1-2-4-14)10-19-21(18)22(28)26-20(25-19)13-30-17-5-7-27(8-6-17)16-11-29-12-16/h9-10,14,16-17,24H,1-8,11-13H2,(H,25,26,28)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434338
PNG
(US10562891, Example 257)
Show SMILES Cc1cc(NC2CCCC2)cc2nc(CSC3CCNCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H28N4OS/c1-13-10-15(22-14-4-2-3-5-14)11-17-19(13)20(25)24-18(23-17)12-26-16-6-8-21-9-7-16/h10-11,14,16,21-22H,2-9,12H2,1H3,(H,23,24,25)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434339
PNG
(US10562891, Example 258)
Show SMILES FC(F)CN1CCC(CC1)SCc1nc2cc(NC3CCCC3)ccc2c(=O)[nH]1
Show InChI InChI=1S/C21H28F2N4OS/c22-19(23)12-27-9-7-16(8-10-27)29-13-20-25-18-11-15(24-14-3-1-2-4-14)5-6-17(18)21(28)26-20/h5-6,11,14,16,19,24H,1-4,7-10,12-13H2,(H,25,26,28)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434350
PNG
(US10562891, Example 269)
Show SMILES CS(=O)(=O)N1CCC[C@H](C1)Nc1cc(F)c2c(c1)nc(CS[C@H]1CC[C@H](O)CC1)[nH]c2=O
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434352
PNG
(US10562891, Example 271)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(NCC3CC3)cc(F)c2c(=O)[nH]1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434363
PNG
(US10562891, Example 282)
Show SMILES Fc1cc(OCC2CCCC2)cc2nc(CSC3CCNCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H26FN3O2S/c21-16-9-14(26-11-13-3-1-2-4-13)10-17-19(16)20(25)24-18(23-17)12-27-15-5-7-22-8-6-15/h9-10,13,15,22H,1-8,11-12H2,(H,23,24,25)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434366
PNG
(US10562891, Example 285)
Show SMILES Fc1cc(NC2CCCC2)cc2nc(CSC3CCN(CC#N)CC3)[nH]c(=O)c12
Show InChI InChI=1S/C21H26FN5OS/c22-17-11-15(24-14-3-1-2-4-14)12-18-20(17)21(28)26-19(25-18)13-29-16-5-8-27(9-6-16)10-7-23/h11-12,14,16,24H,1-6,8-10,13H2,(H,25,26,28)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434368
PNG
(US10562891, Example 287)
Show SMILES Fc1cc(NCCN2CCOCC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H27FN4O3S/c21-16-11-14(22-3-4-25-5-9-28-10-6-25)12-17-19(16)20(26)24-18(23-17)13-29-15-1-7-27-8-2-15/h11-12,15,22H,1-10,13H2,(H,23,24,26)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434374
PNG
(US10562891, Example 293)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(NC3CCCC3)c(F)cc2c(=O)[nH]1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434381
PNG
(US10562891, Example 300)
Show SMILES FC(F)CN1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1
Show InChI InChI=1S/C22H28F3N3O3S/c23-17-9-15(31-12-14-1-5-28(6-2-14)11-19(24)25)10-18-21(17)22(29)27-20(26-18)13-32-16-3-7-30-8-4-16/h9-10,14,16,19H,1-8,11-13H2,(H,26,27,29)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434393
PNG
(US10562891, Example 312)
Show SMILES FC(F)CN1CCCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)C1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434398
PNG
(US10562891, Example 317)
Show SMILES Fc1cc(OCC2CC(F)(F)C2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C19H21F3N2O3S/c20-14-5-12(27-9-11-7-19(21,22)8-11)6-15-17(14)18(25)24-16(23-15)10-28-13-1-3-26-4-2-13/h5-6,11,13H,1-4,7-10H2,(H,23,24,25)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434401
PNG
(US10562891, Example 320)
Show SMILES Fc1cc(OCC2CCCO2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434402
PNG
(US10562891, Example 321a | US10562891, Example 321...)
Show SMILES Fc1cc(OC[C@@H]2CCCO2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434410
PNG
(US10562891, Example 326 | US10562891, Example 327a...)
Show SMILES CN1CC[C@H](COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)[C@@H](F)C1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434410
PNG
(US10562891, Example 326 | US10562891, Example 327a...)
Show SMILES CN1CC[C@H](COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)[C@@H](F)C1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434420
PNG
(US10562891, Example 335a | US10562891, Example 335...)
Show SMILES CN1CC[C@H](COc2cc(F)c3c(c2)nc(CS[C@H]2CC[C@H](O)CC2)[nH]c3=O)[C@@H](F)C1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434420
PNG
(US10562891, Example 335a | US10562891, Example 335...)
Show SMILES CN1CC[C@H](COc2cc(F)c3c(c2)nc(CS[C@H]2CC[C@H](O)CC2)[nH]c3=O)[C@@H](F)C1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434426
PNG
(US10562891, Example 340)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(N[C@H]3CCC[C@@H]3F)cc(F)c2c(=O)[nH]1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434427
PNG
(US10562891, Example 341)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(N[C@@H]3CCC[C@@H]3F)cc(F)c2c(=O)[nH]1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434443
PNG
(US10562891, Example 357)
Show SMILES CO[C@H]1CC[C@H](CC1)SCc1nc2cc(OCC3CCOCC3)cc(F)c2c(=O)[nH]1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434452
PNG
(US10562891, Example 366)
Show SMILES Fc1cc(OCC2CCOCC2)cc2nc(CSC3CCC(F)(F)CC3)[nH]c(=O)c12
Show InChI InChI=1S/C21H25F3N2O3S/c22-16-9-14(29-11-13-3-7-28-8-4-13)10-17-19(16)20(27)26-18(25-17)12-30-15-1-5-21(23,24)6-2-15/h9-10,13,15H,1-8,11-12H2,(H,25,26,27)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434453
PNG
(US10562891, Example 367)
Show SMILES CC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)C1
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434465
PNG
(US10562891, Example 379)
Show SMILES CO[C@@H]1CC[C@@H](CC1)Nc1cc2nc(CS[C@H]3CC[C@H](O)CC3)[nH]c(=O)c2c(F)c1F
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434475
PNG
(US10562891, Example 389)
Show SMILES CO[C@@H]1C[C@@H](C1)Nc1cc2nc(CS[C@H]3CC[C@@H](CC3)NC(C)=O)[nH]c(=O)c2c(F)c1F
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434476
PNG
(US10562891, Example 390)
Show SMILES Fc1cc(OCC2CCN(CC2)C(=O)C2CC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C24H30FN3O4S/c25-19-11-17(32-13-15-3-7-28(8-4-15)24(30)16-1-2-16)12-20-22(19)23(29)27-21(26-20)14-33-18-5-9-31-10-6-18/h11-12,15-16,18H,1-10,13-14H2,(H,26,27,29)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (1611-1801)


(Homo sapiens (Human))
BDBM434484
PNG
(US10562891, Example 398)
Show SMILES CCC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1
Show InChI InChI=1S/C23H30FN3O4S/c1-2-21(28)27-7-3-15(4-8-27)13-31-16-11-18(24)22-19(12-16)25-20(26-23(22)29)14-32-17-5-9-30-10-6-17/h11-12,15,17H,2-10,13-14H2,1H3,(H,25,26,29)
GoogleScholar
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US10562891 (2020)


BindingDB Entry DOI: 10.7270/Q290265W
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 435 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%