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Patent code US10562902

Compile Data Set for Download or QSAR
Found 175 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434742
PNG
(US10562902, Compound 148)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NC3CCOCC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C24H27N7O4S/c1-30-12-17(11-25-30)31-6-2-19-21(31)23(35-18-5-9-34-13-18)29-24(27-19)28-20-10-15(14-36-20)22(32)26-16-3-7-33-8-4-16/h2,6,10-12,14,16,18H,3-5,7-9,13H2,1H3,(H,26,32)(H,27,28,29)/t18-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434748
PNG
(US10562902, Compound 154)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)N3CCS(=O)(=O)CC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C23H25N7O5S2/c1-28-12-16(11-24-28)30-4-2-18-20(30)21(35-17-3-7-34-13-17)27-23(25-18)26-19-10-15(14-36-19)22(31)29-5-8-37(32,33)9-6-29/h2,4,10-12,14,17H,3,5-9,13H2,1H3,(H,25,26,27)/t17-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434753
PNG
(US10562902, Compound 159)
Show SMILES CNC(=O)c1cc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C20H21N7O3S/c1-21-18(28)16-7-12(11-31-16)23-20-24-15-3-5-27(13-8-22-26(2)9-13)17(15)19(25-20)30-14-4-6-29-10-14/h3,5,7-9,11,14H,4,6,10H2,1-2H3,(H,21,28)(H,23,24,25)/t14-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434764
PNG
(US10562902, Compound 170)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NCC(F)F)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C22H23F2N7O3S/c1-30-11-14(9-26-30)31-5-2-16-19(31)21(34-15-3-6-33-7-4-15)29-22(27-16)28-18-8-13(12-35-18)20(32)25-10-17(23)24/h2,5,8-9,11-12,15,17H,3-4,6-7,10H2,1H3,(H,25,32)(H,27,28,29)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434632
PNG
(US10562902, Compound 38)
Show SMILES Cc1cc(Nc2nc(NC3CC[C@H](O)CC3)c3n(ccc3n2)-c2cccnc2)sn1
Show InChI InChI=1S/C21H23N7OS/c1-13-11-18(30-27-13)25-21-24-17-8-10-28(15-3-2-9-22-12-15)19(17)20(26-21)23-14-4-6-16(29)7-5-14/h2-3,8-12,14,16,29H,4-7H2,1H3,(H2,23,24,25,26)/t14?,16-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434700
PNG
(US10562902, Compound 106)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnnc3)nc(O[C@H]3CCOC3)c12
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434732
PNG
(US10562902, Compound 138)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NCC(F)(F)F)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C21H20F3N7O3S/c1-30-8-13(7-26-30)31-4-2-15-17(31)19(34-14-3-5-33-9-14)29-20(27-15)28-16-6-12(10-35-16)18(32)25-11-21(22,23)24/h2,4,6-8,10,14H,3,5,9,11H2,1H3,(H,25,32)(H,27,28,29)/t14-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434743
PNG
(US10562902, Compound 149)
Show SMILES CN(C)C(=O)c1csc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C21H23N7O3S/c1-26(2)20(29)13-8-17(32-12-13)24-21-23-16-4-6-28(14-9-22-27(3)10-14)18(16)19(25-21)31-15-5-7-30-11-15/h4,6,8-10,12,15H,5,7,11H2,1-3H3,(H,23,24,25)/t15-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434744
PNG
(US10562902, Compound 150 | US10562902, Compound 15...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)N3CCCCC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C24H27N7O3S/c1-29-13-17(12-25-29)31-9-5-19-21(31)22(34-18-6-10-33-14-18)28-24(26-19)27-20-11-16(15-35-20)23(32)30-7-3-2-4-8-30/h5,9,11-13,15,18H,2-4,6-8,10,14H2,1H3,(H,26,27,28)/t18-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434751
PNG
(US10562902, Compound 157)
Show SMILES CNC(=O)c1ccc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434752
PNG
(US10562902, Compound 158)
Show SMILES CNC(=O)c1cc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)ss1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434598
PNG
(US10562902, Compound 4)
Show SMILES CCCCNc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C18H22N8S/c1-4-5-7-19-17-16-14(6-8-26(16)13-10-20-25(3)11-13)21-18(23-17)22-15-9-12(2)24-27-15/h6,8-11H,4-5,7H2,1-3H3,(H2,19,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434665
PNG
(US10562902, Compound 71 | US10562902, Compound 74)
Show SMILES Cc1cc(Nc2nc(OC3CCNCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H22N8OS/c1-12-9-16(29-25-12)23-19-22-15-5-8-27(13-10-21-26(2)11-13)17(15)18(24-19)28-14-3-6-20-7-4-14/h5,8-11,14,20H,3-4,6-7H2,1-2H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434681
PNG
(US10562902, Compound 87)
Show SMILES Cc1cc(Nc2nc(OC3CCCC3)c3n(ccc3n2)-c2ccoc2)sn1
Show InChI InChI=1S/C19H19N5O2S/c1-12-10-16(27-23-12)21-19-20-15-6-8-24(13-7-9-25-11-13)17(15)18(22-19)26-14-4-2-3-5-14/h6-11,14H,2-5H2,1H3,(H,20,21,22)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434730
PNG
(US10562902, Compound 136)
Show SMILES CC(C)NC(=O)c1csc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H25N7O3S/c1-13(2)24-20(30)14-8-18(33-12-14)26-22-25-17-4-6-29(15-9-23-28(3)10-15)19(17)21(27-22)32-16-5-7-31-11-16/h4,6,8-10,12-13,16H,5,7,11H2,1-3H3,(H,24,30)(H,25,26,27)/t16-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434734
PNG
(US10562902, Compound 140)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NCC3CCOCC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C25H29N7O4S/c1-31-13-18(12-27-31)32-6-2-20-22(32)24(36-19-5-9-35-14-19)30-25(28-20)29-21-10-17(15-37-21)23(33)26-11-16-3-7-34-8-4-16/h2,6,10,12-13,15-16,19H,3-5,7-9,11,14H2,1H3,(H,26,33)(H,28,29,30)/t19-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434749
PNG
(US10562902, Compound 155)
Show SMILES CNC(=O)c1ccc(Nc2nc(OCCOC)c3n(ccc3n2)-c2cnn(C)c2)c1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434754
PNG
(US10562902, Compound 160)
Show SMILES CCNC(=O)c1cc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C21H23N7O3S/c1-3-22-19(29)17-8-13(12-32-17)24-21-25-16-4-6-28(14-9-23-27(2)10-14)18(16)20(26-21)31-15-5-7-30-11-15/h4,6,8-10,12,15H,3,5,7,11H2,1-2H3,(H,22,29)(H,24,25,26)/t15-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434765
PNG
(US10562902, Compound 171)
Show SMILES CN(C)C(=O)c1csc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H25N7O3S/c1-27(2)21(30)14-10-18(33-13-14)25-22-24-17-4-7-29(15-11-23-28(3)12-15)19(17)20(26-22)32-16-5-8-31-9-6-16/h4,7,10-13,16H,5-6,8-9H2,1-3H3,(H,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434595
PNG
(US10562902, Compound 1)
Show SMILES Cc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H24N8OS/c1-12-9-17(30-26-12)24-20-23-16-7-8-28(14-10-21-27(2)11-14)18(16)19(25-20)22-13-3-5-15(29)6-4-13/h7-11,13,15,29H,3-6H2,1-2H3,(H2,22,23,24,25)/t13-,15-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434613
PNG
(US10562902, Compound 19)
Show SMILES Cc1cc(Nc2nc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H24N8O3S/c1-10-5-15(32-26-10)24-20-23-13-3-4-28(12-7-21-27(2)8-12)16(13)19(25-20)22-14-6-11(9-29)17(30)18(14)31/h3-5,7-8,11,14,17-18,29-31H,6,9H2,1-2H3,(H2,22,23,24,25)/t11-,14-,17-,18+/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434656
PNG
(US10562902, Compound 62)
Show SMILES Cc1cc(Nc2nc(OC3CC(C3)N3CCCCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C23H28N8OS/c1-15-10-20(33-28-15)26-23-25-19-6-9-31(17-13-24-29(2)14-17)21(19)22(27-23)32-18-11-16(12-18)30-7-4-3-5-8-30/h6,9-10,13-14,16,18H,3-5,7-8,11-12H2,1-2H3,(H,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434659
PNG
(US10562902, Compound 65)
Show SMILES Cc1cc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C18H19N7O2S/c1-11-7-15(28-23-11)21-18-20-14-3-5-25(12-8-19-24(2)9-12)16(14)17(22-18)27-13-4-6-26-10-13/h3,5,7-9,13H,4,6,10H2,1-2H3,(H,20,21,22)/t13-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434671
PNG
(US10562902, Compound 77)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccnc3)nc(O[C@H]3CCOC3)c12
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434714
PNG
(US10562902, Compound 120 | US10562902, Compound 12...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc4C(=O)NCc4c3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C22H21N7O3/c1-28-11-15(10-24-28)29-6-4-18-19(29)21(32-16-5-7-31-12-16)27-22(26-18)25-14-2-3-17-13(8-14)9-23-20(17)30/h2-4,6,8,10-11,16H,5,7,9,12H2,1H3,(H,23,30)(H,25,26,27)/t16-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434726
PNG
(US10562902, Compound 132)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc(c3)C(N)=O)nc(O[C@@H]3CCOC3)c12
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434728
PNG
(US10562902, Compound 134)
Show SMILES CCNC(=O)c1csc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C21H23N7O3S/c1-3-22-19(29)13-8-17(32-12-13)25-21-24-16-4-6-28(14-9-23-27(2)10-14)18(16)20(26-21)31-15-5-7-30-11-15/h4,6,8-10,12,15H,3,5,7,11H2,1-2H3,(H,22,29)(H,24,25,26)/t15-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434739
PNG
(US10562902, Compound 145)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NC3CCNCC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C24H28N8O3S/c1-31-12-17(11-26-31)32-8-4-19-21(32)23(35-18-5-9-34-13-18)30-24(28-19)29-20-10-15(14-36-20)22(33)27-16-2-6-25-7-3-16/h4,8,10-12,14,16,18,25H,2-3,5-7,9,13H2,1H3,(H,27,33)(H,28,29,30)/t18-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434740
PNG
(US10562902, Compound 146 | US10562902, Compound 14...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NC3CCOC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C23H25N7O4S/c1-29-10-16(9-24-29)30-5-2-18-20(30)22(34-17-4-7-33-12-17)28-23(26-18)27-19-8-14(13-35-19)21(31)25-15-3-6-32-11-15/h2,5,8-10,13,15,17H,3-4,6-7,11-12H2,1H3,(H,25,31)(H,26,27,28)/t15?,17-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434760
PNG
(US10562902, Compound 166)
Show SMILES CNC(=O)c1cc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H20N8O3S/c1-20-17(28)14-7-15(31-25-14)23-19-22-13-3-5-27(11-8-21-26(2)9-11)16(13)18(24-19)30-12-4-6-29-10-12/h3,5,7-9,12H,4,6,10H2,1-2H3,(H,20,28)(H,22,23,24)/t12-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434596
PNG
(US10562902, Compound 2)
Show SMILES CC(C)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C17H20N8S/c1-10(2)19-16-15-13(5-6-25(15)12-8-18-24(4)9-12)20-17(22-16)21-14-7-11(3)23-26-14/h5-10H,1-4H3,(H2,19,20,21,22)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434599
PNG
(US10562902, Compound 5)
Show SMILES Cc1cc(Nc2nc(NCCCCO)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C18H22N8OS/c1-12-9-15(28-24-12)22-18-21-14-5-7-26(13-10-20-25(2)11-13)16(14)17(23-18)19-6-3-4-8-27/h5,7,9-11,27H,3-4,6,8H2,1-2H3,(H2,19,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434643
PNG
(US10562902, Compound 49)
Show SMILES CCNC(=O)c1csc(Nc2nc(NC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H26N8O2S/c1-3-23-21(31)14-10-18(33-13-14)27-22-26-17-4-7-30(16-11-24-29(2)12-16)19(17)20(28-22)25-15-5-8-32-9-6-15/h4,7,10-13,15H,3,5-6,8-9H2,1-2H3,(H,23,31)(H2,25,26,27,28)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434655
PNG
(US10562902, Compound 61)
Show SMILES Cc1cc(Nc2nc(OC3COC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C17H17N7O2S/c1-10-5-14(27-22-10)20-17-19-13-3-4-24(11-6-18-23(2)7-11)15(13)16(21-17)26-12-8-25-9-12/h3-7,12H,8-9H2,1-2H3,(H,19,20,21)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434699
PNG
(US10562902, Compound 105)
Show SMILES Cn1cc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C18H20N8O2/c1-24-9-12(7-19-24)21-18-22-15-3-5-26(13-8-20-25(2)10-13)16(15)17(23-18)28-14-4-6-27-11-14/h3,5,7-10,14H,4,6,11H2,1-2H3,(H,21,22,23)/t14-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434708
PNG
(US10562902, Compound 114)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnn(c3)-c3cccnc3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C22H21N9O2/c1-29-13-17(11-24-29)30-7-4-19-20(30)21(33-18-5-8-32-14-18)28-22(27-19)26-15-9-25-31(12-15)16-3-2-6-23-10-16/h2-4,6-7,9-13,18H,5,8,14H2,1H3,(H,26,27,28)/t18-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434720
PNG
(US10562902, Compound 126)
Show SMILES CNC(=O)c1ccc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2ccoc2)c1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434725
PNG
(US10562902, Compound 131)
Show SMILES CCNC(=O)c1cc(Nc2nc(OC3CCCC3)c3n(ccc3n2)-c2cnn(C)c2)ss1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434740
PNG
(US10562902, Compound 146 | US10562902, Compound 14...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NC3CCOC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C23H25N7O4S/c1-29-10-16(9-24-29)30-5-2-18-20(30)22(34-17-4-7-33-12-17)28-23(26-18)27-19-8-14(13-35-19)21(31)25-15-3-6-32-11-15/h2,5,8-10,13,15,17H,3-4,6-7,11-12H2,1H3,(H,25,31)(H,26,27,28)/t15?,17-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434755
PNG
(US10562902, Compound 161)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3csc(c3)C(=O)NCCF)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C21H22FN7O3S/c1-28-10-14(9-24-28)29-6-2-16-18(29)20(32-15-3-7-31-11-15)27-21(26-16)25-13-8-17(33-12-13)19(30)23-5-4-22/h2,6,8-10,12,15H,3-5,7,11H2,1H3,(H,23,30)(H,25,26,27)/t15-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434761
PNG
(US10562902, Compound 167 | US10562902, Compound 17...)
Show SMILES CNC(=O)c1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C21H23N7O3S/c1-22-19(29)17-9-13(12-32-17)24-21-25-16-3-6-28(14-10-23-27(2)11-14)18(16)20(26-21)31-15-4-7-30-8-5-15/h3,6,9-12,15H,4-5,7-8H2,1-2H3,(H,22,29)(H,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434761
PNG
(US10562902, Compound 167 | US10562902, Compound 17...)
Show SMILES CNC(=O)c1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C21H23N7O3S/c1-22-19(29)17-9-13(12-32-17)24-21-25-16-3-6-28(14-10-23-27(2)11-14)18(16)20(26-21)31-15-4-7-30-8-5-15/h3,6,9-12,15H,4-5,7-8H2,1-2H3,(H,22,29)(H,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434658
PNG
(US10562902, Compound 64)
Show SMILES Cc1cc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C18H19N7O2S/c1-11-7-15(28-23-11)21-18-20-14-3-5-25(12-8-19-24(2)9-12)16(14)17(22-18)27-13-4-6-26-10-13/h3,5,7-9,13H,4,6,10H2,1-2H3,(H,20,21,22)/t13-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434672
PNG
(US10562902, Compound 78)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccsc3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C18H18N6O2S/c1-23-9-13(8-19-23)24-5-2-15-16(24)17(26-14-3-6-25-10-14)22-18(21-15)20-12-4-7-27-11-12/h2,4-5,7-9,11,14H,3,6,10H2,1H3,(H,20,21,22)/t14-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434721
PNG
(US10562902, Compound 127)
Show SMILES CCNC(=O)c1cc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)ss1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434724
PNG
(US10562902, Compound 130)
Show SMILES CCNC(=O)c1csc(Nc2nc(OCCOC)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C20H23N7O3S/c1-4-21-18(28)13-9-16(31-12-13)24-20-23-15-5-6-27(14-10-22-26(2)11-14)17(15)19(25-20)30-8-7-29-3/h5-6,9-12H,4,7-8H2,1-3H3,(H,21,28)(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434750
PNG
(US10562902, Compound 156)
Show SMILES CCNC(=O)c1cc(Nc2nc(OCCOC)c3n(ccc3n2)-c2cnn(C)c2)ss1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434757
PNG
(US10562902, Compound 163)
Show SMILES CN(C)C(=O)c1cc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C21H23N7O3S/c1-26(2)20(29)17-8-13(12-32-17)23-21-24-16-4-6-28(14-9-22-27(3)10-14)18(16)19(25-21)31-15-5-7-30-11-15/h4,6,8-10,12,15H,5,7,11H2,1-3H3,(H,23,24,25)/t15-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434762
PNG
(US10562902, Compound 168 | US10562902, Compound 17...)
Show SMILES CCNC(=O)c1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C22H25N7O3S/c1-3-23-20(30)18-10-14(13-33-18)25-22-26-17-4-7-29(15-11-24-28(2)12-15)19(17)21(27-22)32-16-5-8-31-9-6-16/h4,7,10-13,16H,3,5-6,8-9H2,1-2H3,(H,23,30)(H,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434620
PNG
(US10562902, Compound 26)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C21H26N8OS/c1-13-10-18(31-27-13)25-21-24-17-8-9-29(15-11-22-28(2)12-15)19(17)20(26-21)23-14-4-6-16(30-3)7-5-14/h8-12,14,16H,4-7H2,1-3H3,(H2,23,24,25,26)/t14-,16-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434645
PNG
(US10562902, Compound 51)
Show SMILES CNC(=O)c1csc(Nc2nc(NC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C21H24N8O2S/c1-22-20(30)13-9-17(32-12-13)26-21-25-16-3-6-29(15-10-23-28(2)11-15)18(16)19(27-21)24-14-4-7-31-8-5-14/h3,6,9-12,14H,4-5,7-8H2,1-2H3,(H,22,30)(H2,24,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434701
PNG
(US10562902, Compound 107)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnn(CCF)c3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C19H21FN8O2/c1-26-11-14(9-21-26)28-5-2-16-17(28)18(30-15-3-7-29-12-15)25-19(24-16)23-13-8-22-27(10-13)6-4-20/h2,5,8-11,15H,3-4,6-7,12H2,1H3,(H,23,24,25)/t15-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434702
PNG
(US10562902, Compound 108)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnn(CCO)c3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C19H22N8O3/c1-25-11-14(9-20-25)27-4-2-16-17(27)18(30-15-3-7-29-12-15)24-19(23-16)22-13-8-21-26(10-13)5-6-28/h2,4,8-11,15,28H,3,5-7,12H2,1H3,(H,22,23,24)/t15-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434704
PNG
(US10562902, Compound 110)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnn(c3)C3CCOCC3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C22H26N8O3/c1-28-13-17(11-23-28)29-6-2-19-20(29)21(33-18-5-9-32-14-18)27-22(26-19)25-15-10-24-30(12-15)16-3-7-31-8-4-16/h2,6,10-13,16,18H,3-5,7-9,14H2,1H3,(H,25,26,27)/t18-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434735
PNG
(US10562902, Compound 141)
Show SMILES CN1CCC(CNC(=O)c2csc(Nc3nc(O[C@@H]4CCOC4)c4n(ccc4n3)-c3cnn(C)c3)c2)CC1
Show InChI InChI=1S/C26H32N8O3S/c1-32-7-3-17(4-8-32)12-27-24(35)18-11-22(38-16-18)30-26-29-21-5-9-34(19-13-28-33(2)14-19)23(21)25(31-26)37-20-6-10-36-15-20/h5,9,11,13-14,16-17,20H,3-4,6-8,10,12,15H2,1-2H3,(H,27,35)(H,29,30,31)/t20-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434737
PNG
(US10562902, Compound 143)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NC3CC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C22H23N7O3S/c1-28-10-15(9-23-28)29-6-4-17-19(29)21(32-16-5-7-31-11-16)27-22(25-17)26-18-8-13(12-33-18)20(30)24-14-2-3-14/h4,6,8-10,12,14,16H,2-3,5,7,11H2,1H3,(H,24,30)(H,25,26,27)/t16-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434756
PNG
(US10562902, Compound 162)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C25H30N8O3S/c1-31-7-3-16(4-8-31)27-23(34)21-11-17(15-37-21)28-25-29-20-5-9-33(18-12-26-32(2)13-18)22(20)24(30-25)36-19-6-10-35-14-19/h5,9,11-13,15-16,19H,3-4,6-8,10,14H2,1-2H3,(H,27,34)(H,28,29,30)/t19-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434762
PNG
(US10562902, Compound 168 | US10562902, Compound 17...)
Show SMILES CCNC(=O)c1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C22H25N7O3S/c1-3-23-20(30)18-10-14(13-33-18)25-22-26-17-4-7-29(15-11-24-28(2)12-15)19(17)21(27-22)32-16-5-8-31-9-6-16/h4,7,10-13,16H,3,5-6,8-9H2,1-2H3,(H,23,30)(H,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434608
PNG
(US10562902, Compound 14)
Show SMILES Cc1cc(Nc2nc(N[C@H]3C[C@@](C)(O)C3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H22N8OS/c1-11-6-15(29-25-11)23-18-22-14-4-5-27(13-9-20-26(3)10-13)16(14)17(24-18)21-12-7-19(2,28)8-12/h4-6,9-10,12,28H,7-8H2,1-3H3,(H2,21,22,23,24)/t12-,19+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434612
PNG
(US10562902, Compound 18)
Show SMILES C[C@@H]1CC[C@@H](C1)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C20H24N8S/c1-12-4-5-14(8-12)22-19-18-16(6-7-28(18)15-10-21-27(3)11-15)23-20(25-19)24-17-9-13(2)26-29-17/h6-7,9-12,14H,4-5,8H2,1-3H3,(H2,22,23,24,25)/t12-,14+/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434623
PNG
(US10562902, Compound 29)
Show SMILES Cc1cc(Nc2nc(NC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H22N8OS/c1-12-9-16(29-25-12)23-19-22-15-3-6-27(14-10-20-26(2)11-14)17(15)18(24-19)21-13-4-7-28-8-5-13/h3,6,9-11,13H,4-5,7-8H2,1-2H3,(H2,21,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434642
PNG
(US10562902, Compound 48)
Show SMILES CNC(=O)c1csc(Nc2nc(N(C)C3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H26N8O2S/c1-23-21(31)14-10-18(33-13-14)26-22-25-17-4-7-30(16-11-24-28(2)12-16)19(17)20(27-22)29(3)15-5-8-32-9-6-15/h4,7,10-13,15H,5-6,8-9H2,1-3H3,(H,23,31)(H,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434705
PNG
(US10562902, Compound 111)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnn(c3)C3CCNCC3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C22H27N9O2/c1-29-13-17(11-24-29)30-8-4-19-20(30)21(33-18-5-9-32-14-18)28-22(27-19)26-15-10-25-31(12-15)16-2-6-23-7-3-16/h4,8,10-13,16,18,23H,2-3,5-7,9,14H2,1H3,(H,26,27,28)/t18-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434706
PNG
(US10562902, Compound 112 | US10562902, Compound 11...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnn(c3)-c3ccccc3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C23H22N8O2/c1-29-14-18(12-24-29)30-9-7-20-21(30)22(33-19-8-10-32-15-19)28-23(27-20)26-16-11-25-31(13-16)17-5-3-2-4-6-17/h2-7,9,11-14,19H,8,10,15H2,1H3,(H,26,27,28)/t19-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434717
PNG
(US10562902, Compound 123)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc4CN=Cc4c3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C22H21N7O2/c1-28-12-17(11-24-28)29-6-4-19-20(29)21(31-18-5-7-30-13-18)27-22(26-19)25-16-3-2-14-9-23-10-15(14)8-16/h2-4,6,8,10-12,18H,5,7,9,13H2,1H3,(H,25,26,27)/t18-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434727
PNG
(US10562902, Compound 133)
Show SMILES CNC(=O)c1csc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C20H21N7O3S/c1-21-18(28)12-7-16(31-11-12)24-20-23-15-3-5-27(13-8-22-26(2)9-13)17(15)19(25-20)30-14-4-6-29-10-14/h3,5,7-9,11,14H,4,6,10H2,1-2H3,(H,21,28)(H,23,24,25)/t14-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434731
PNG
(US10562902, Compound 137)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NCCF)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C21H22FN7O3S/c1-28-10-14(9-24-28)29-6-2-16-18(29)20(32-15-3-7-31-11-15)27-21(25-16)26-17-8-13(12-33-17)19(30)23-5-4-22/h2,6,8-10,12,15H,3-5,7,11H2,1H3,(H,23,30)(H,25,26,27)/t15-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434733
PNG
(US10562902, Compound 139)
Show SMILES COCCNC(=O)c1csc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H25N7O4S/c1-28-11-15(10-24-28)29-6-3-17-19(29)21(33-16-4-7-32-12-16)27-22(25-17)26-18-9-14(13-34-18)20(30)23-5-8-31-2/h3,6,9-11,13,16H,4-5,7-8,12H2,1-2H3,(H,23,30)(H,25,26,27)/t16-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434745
PNG
(US10562902, Compound 151)
Show SMILES CN1CCN(CC1)C(=O)c1csc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C24H28N8O3S/c1-29-6-8-31(9-7-29)23(33)16-11-20(36-15-16)27-24-26-19-3-5-32(17-12-25-30(2)13-17)21(19)22(28-24)35-18-4-10-34-14-18/h3,5,11-13,15,18H,4,6-10,14H2,1-2H3,(H,26,27,28)/t18-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434744
PNG
(US10562902, Compound 150 | US10562902, Compound 15...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)N3CCCCC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C24H27N7O3S/c1-29-13-17(12-25-29)31-9-5-19-21(31)22(34-18-6-10-33-14-18)28-24(26-19)27-20-11-16(15-35-20)23(32)30-7-3-2-4-8-30/h5,9,11-13,15,18H,2-4,6-8,10,14H2,1H3,(H,26,27,28)/t18-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434763
PNG
(US10562902, Compound 169)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NCCF)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C22H24FN7O3S/c1-29-12-15(11-25-29)30-7-2-17-19(30)21(33-16-3-8-32-9-4-16)28-22(26-17)27-18-10-14(13-34-18)20(31)24-6-5-23/h2,7,10-13,16H,3-6,8-9H2,1H3,(H,24,31)(H,26,27,28)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434607
PNG
(US10562902, Compound 13)
Show SMILES Cc1cc(Nc2nc(NC3CC(O)C3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C18H20N8OS/c1-10-5-15(28-24-10)22-18-21-14-3-4-26(12-8-19-25(2)9-12)16(14)17(23-18)20-11-6-13(27)7-11/h3-5,8-9,11,13,27H,6-7H2,1-2H3,(H2,20,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434648
PNG
(US10562902, Compound 54)
Show SMILES CC(C)Oc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C17H19N7OS/c1-10(2)25-16-15-13(5-6-24(15)12-8-18-23(4)9-12)19-17(21-16)20-14-7-11(3)22-26-14/h5-10H,1-4H3,(H,19,20,21)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434649
PNG
(US10562902, Compound 55)
Show SMILES CCCCOc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C18H21N7OS/c1-4-5-8-26-17-16-14(6-7-25(16)13-10-19-24(3)11-13)20-18(22-17)21-15-9-12(2)23-27-15/h6-7,9-11H,4-5,8H2,1-3H3,(H,20,21,22)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434660
PNG
(US10562902, Compound 66)
Show SMILES Cc1cc(Nc2nc(OC3CCCCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H23N7OS/c1-13-10-17(29-25-13)23-20-22-16-8-9-27(14-11-21-26(2)12-14)18(16)19(24-20)28-15-6-4-3-5-7-15/h8-12,15H,3-7H2,1-2H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434715
PNG
(US10562902, Compound 121)
Show SMILES CN1Cc2cc(Nc3nc(O[C@H]4CCOC4)c4n(ccc4n3)-c3cnn(C)c3)ccc2C1=O
Show InChI InChI=1S/C23H23N7O3/c1-28-11-14-9-15(3-4-18(14)22(28)31)25-23-26-19-5-7-30(16-10-24-29(2)12-16)20(19)21(27-23)33-17-6-8-32-13-17/h3-5,7,9-10,12,17H,6,8,11,13H2,1-2H3,(H,25,26,27)/t17-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434631
PNG
(US10562902, Compound 37)
Show SMILES CC(C)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cccnc3)c12
Show InChI InChI=1S/C18H19N7S/c1-11(2)20-17-16-14(6-8-25(16)13-5-4-7-19-10-13)21-18(23-17)22-15-9-12(3)24-26-15/h4-11H,1-3H3,(H2,20,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434635
PNG
(US10562902, Compound 41)
Show SMILES CC(C)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3ccnc(O)c3)c12
Show InChI InChI=1S/C18H19N7OS/c1-10(2)20-17-16-13(5-7-25(16)12-4-6-19-14(26)9-12)21-18(23-17)22-15-8-11(3)24-27-15/h4-10H,1-3H3,(H,19,26)(H2,20,21,22,23)
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n/an/a 550n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434675
PNG
(US10562902, Compound 81)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccss3)nc(O[C@H]3CCOC3)c12
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n/an/a 550n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434676
PNG
(US10562902, Compound 82)
Show SMILES Cc1cc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C19H20N6O2S/c1-12-7-13(11-28-12)21-19-22-16-3-5-25(14-8-20-24(2)9-14)17(16)18(23-19)27-15-4-6-26-10-15/h3,5,7-9,11,15H,4,6,10H2,1-2H3,(H,21,22,23)/t15-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434680
PNG
(US10562902, Compound 86)
Show SMILES Cc1cc(Nc2nc(OC3CCCCC3)c3n(ccc3n2)-c2ccn(C)c2)sn1
Show InChI InChI=1S/C21H24N6OS/c1-14-12-18(29-25-14)23-21-22-17-9-11-27(15-8-10-26(2)13-15)19(17)20(24-21)28-16-6-4-3-5-7-16/h8-13,16H,3-7H2,1-2H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434694
PNG
(US10562902, Compound 100)
Show SMILES Cc1cc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2ccncc2)sn1
Show InChI InChI=1S/C19H18N6O2S/c1-12-10-16(28-24-12)22-19-21-15-4-8-25(13-2-6-20-7-3-13)17(15)18(23-19)27-14-5-9-26-11-14/h2-4,6-8,10,14H,5,9,11H2,1H3,(H,21,22,23)/t14-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434696
PNG
(US10562902, Compound 102)
Show SMILES Cc1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2ccnnc2)sn1
Show InChI InChI=1S/C19H19N7O2S/c1-12-10-16(29-25-12)23-19-22-15-3-7-26(13-2-6-20-21-11-13)17(15)18(24-19)28-14-4-8-27-9-5-14/h2-3,6-7,10-11,14H,4-5,8-9H2,1H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434712
PNG
(US10562902, Compound 118)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc(cc3)N3CCCCC3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C25H29N7O2/c1-30-16-20(15-26-30)32-13-9-22-23(32)24(34-21-10-14-33-17-21)29-25(28-22)27-18-5-7-19(8-6-18)31-11-3-2-4-12-31/h5-9,13,15-16,21H,2-4,10-12,14,17H2,1H3,(H,27,28,29)/t21-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434714
PNG
(US10562902, Compound 120 | US10562902, Compound 12...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc4C(=O)NCc4c3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C22H21N7O3/c1-28-11-15(10-24-28)29-6-4-18-19(29)21(32-16-5-7-31-12-16)27-22(26-18)25-14-2-3-17-13(8-14)9-23-20(17)30/h2-4,6,8,10-11,16H,5,7,9,12H2,1H3,(H,23,30)(H,25,26,27)/t16-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434719
PNG
(US10562902, Compound 125)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc4ncsc4c3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C21H19N7O2S/c1-27-10-14(9-23-27)28-6-4-17-19(28)20(30-15-5-7-29-11-15)26-21(25-17)24-13-2-3-16-18(8-13)31-12-22-16/h2-4,6,8-10,12,15H,5,7,11H2,1H3,(H,24,25,26)/t15-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434604
PNG
(US10562902, Compound 10)
Show SMILES Cc1cc(Nc2nc(NCCN3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H25N9OS/c1-14-11-17(31-26-14)24-20-23-16-3-5-29(15-12-22-27(2)13-15)18(16)19(25-20)21-4-6-28-7-9-30-10-8-28/h3,5,11-13H,4,6-10H2,1-2H3,(H2,21,23,24,25)
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n/an/a 550n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434609
PNG
(US10562902, Compound 15)
Show SMILES Cc1cc(Nc2nc(N[C@H]3C[C@H](C3)C3CCCCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C24H30N8S/c1-15-10-21(33-30-15)28-24-27-20-8-9-32(19-13-25-31(2)14-19)22(20)23(29-24)26-18-11-17(12-18)16-6-4-3-5-7-16/h8-10,13-14,16-18H,3-7,11-12H2,1-2H3,(H2,26,27,28,29)/t17-,18+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434616
PNG
(US10562902, Compound 22)
Show SMILES Cc1cc(Nc2nc(NC3CCCCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H24N8S/c1-13-10-17(29-26-13)24-20-23-16-8-9-28(15-11-21-27(2)12-15)18(16)19(25-20)22-14-6-4-3-5-7-14/h8-12,14H,3-7H2,1-2H3,(H2,22,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434637
PNG
(US10562902, Compound 43)
Show SMILES CC(C)Nc1nc(Nc2cc(C)ns2)nc2ccn(C3=CC=[N]4OCOC4=C3)c12
Show InChI InChI=1S/C19H20N7O2S/c1-11(2)20-18-17-14(21-19(23-18)22-15-8-12(3)24-29-15)5-6-25(17)13-4-7-26-16(9-13)27-10-28-26/h4-9,11H,10H2,1-3H3,(H2,20,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434639
PNG
(US10562902, Compound 45)
Show SMILES CC(C)Nc1nc(Nc2cnn(c2)C2CCCCC2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C22H29N9/c1-15(2)25-21-20-19(9-10-30(20)18-12-23-29(3)14-18)27-22(28-21)26-16-11-24-31(13-16)17-7-5-4-6-8-17/h9-15,17H,4-8H2,1-3H3,(H2,25,26,27,28)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434644
PNG
(US10562902, Compound 50 | US10562902, Compound 52)
Show SMILES CN(C)C(=O)c1csc(Nc2nc(NC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H26N8O2S/c1-28(2)21(31)14-10-18(33-13-14)26-22-25-17-4-7-30(16-11-23-29(3)12-16)19(17)20(27-22)24-15-5-8-32-9-6-15/h4,7,10-13,15H,5-6,8-9H2,1-3H3,(H2,24,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434663
PNG
(US10562902, Compound 69)
Show SMILES Cc1cc(Nc2nc(OC3CCCNC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H22N8OS/c1-12-8-16(29-25-12)23-19-22-15-5-7-27(13-9-21-26(2)11-13)17(15)18(24-19)28-14-4-3-6-20-10-14/h5,7-9,11,14,20H,3-4,6,10H2,1-2H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434665
PNG
(US10562902, Compound 71 | US10562902, Compound 74)
Show SMILES Cc1cc(Nc2nc(OC3CCNCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H22N8OS/c1-12-9-16(29-25-12)23-19-22-15-5-8-27(13-10-21-26(2)11-13)17(15)18(24-19)28-14-3-6-20-7-4-14/h5,8-11,14,20H,3-4,6-7H2,1-2H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434674
PNG
(US10562902, Compound 80)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc(s3)C#N)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C19H17N7O2S/c1-25-10-12(9-21-25)26-6-4-15-17(26)18(28-13-5-7-27-11-13)24-19(22-15)23-16-3-2-14(8-20)29-16/h2-4,6,9-10,13H,5,7,11H2,1H3,(H,22,23,24)/t13-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434722
PNG
(US10562902, Compound 128)
Show SMILES CCNC(=O)c1ccc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434736
PNG
(US10562902, Compound 142)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NCc3cccs3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C24H23N7O3S2/c1-30-12-16(10-26-30)31-6-4-19-21(31)23(34-17-5-7-33-13-17)29-24(27-19)28-20-9-15(14-36-20)22(32)25-11-18-3-2-8-35-18/h2-4,6,8-10,12,14,17H,5,7,11,13H2,1H3,(H,25,32)(H,27,28,29)/t17-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434758
PNG
(US10562902, Compound 164)
Show SMILES CNC(=O)c1ccc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)s1
Show InChI InChI=1S/C20H21N7O3S/c1-21-18(28)15-3-4-16(31-15)24-20-23-14-5-7-27(12-9-22-26(2)10-12)17(14)19(25-20)30-13-6-8-29-11-13/h3-5,7,9-10,13H,6,8,11H2,1-2H3,(H,21,28)(H,23,24,25)/t13-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434769
PNG
(US10562902, Compound 175)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc4C(=O)NCCn4c3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C22H24N8O3/c1-28-13-15(11-24-28)30-6-2-17-19(30)21(33-16-3-8-32-9-4-16)27-22(26-17)25-14-10-18-20(31)23-5-7-29(18)12-14/h2,6,10-13,16H,3-5,7-9H2,1H3,(H,23,31)(H,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434600
PNG
(US10562902, Compound 6)
Show SMILES Cc1cc(Nc2nc(NCCC(=O)NO)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C17H19N9O2S/c1-10-7-14(29-24-10)21-17-20-12-4-6-26(11-8-19-25(2)9-11)15(12)16(22-17)18-5-3-13(27)23-28/h4,6-9,28H,3,5H2,1-2H3,(H,23,27)(H2,18,20,21,22)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434606
PNG
(US10562902, Compound 12)
Show SMILES Cc1cc(Nc2nc(NC3CCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C18H20N8S/c1-11-8-15(27-24-11)22-18-21-14-6-7-26(13-9-19-25(2)10-13)16(14)17(23-18)20-12-4-3-5-12/h6-10,12H,3-5H2,1-2H3,(H2,20,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434636
PNG
(US10562902, Compound 42)
Show SMILES COc1cc(ccn1)-n1ccc2nc(Nc3cc(C)ns3)nc(NC(C)C)c12
Show InChI InChI=1S/C19H21N7OS/c1-11(2)21-18-17-14(22-19(24-18)23-16-9-12(3)25-28-16)6-8-26(17)13-5-7-20-15(10-13)27-4/h5-11H,1-4H3,(H2,21,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434650
PNG
(US10562902, Compound 56)
Show SMILES COCC(C)Oc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C18H21N7O2S/c1-11-7-15(28-23-11)21-18-20-14-5-6-25(13-8-19-24(3)9-13)16(14)17(22-18)27-12(2)10-26-4/h5-9,12H,10H2,1-4H3,(H,20,21,22)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434652
PNG
(US10562902, Compound 58)
Show SMILES Cc1cc(Nc2nc(OCC3CCNC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H22N8OS/c1-12-7-16(29-25-12)23-19-22-15-4-6-27(14-9-21-26(2)10-14)17(15)18(24-19)28-11-13-3-5-20-8-13/h4,6-7,9-10,13,20H,3,5,8,11H2,1-2H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434678
PNG
(US10562902, Compound 84)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccnn3)nc(O[C@H]3CCOC3)c12
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434684
PNG
(US10562902, Compound 90)
Show SMILES CCn1cc(cn1)-n1ccc2nc(Nc3cc(C)ns3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C20H23N7O2S/c1-3-26-12-14(11-21-26)27-7-4-16-18(27)19(29-15-5-8-28-9-6-15)24-20(22-16)23-17-10-13(2)25-30-17/h4,7,10-12,15H,3,5-6,8-9H2,1-2H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434685
PNG
(US10562902, Compound 91)
Show SMILES COCCn1cc(cn1)-n1ccc2nc(Nc3cc(C)ns3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C21H25N7O3S/c1-14-11-18(32-26-14)24-21-23-17-3-6-28(15-12-22-27(13-15)7-10-29-2)19(17)20(25-21)31-16-4-8-30-9-5-16/h3,6,11-13,16H,4-5,7-10H2,1-2H3,(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434686
PNG
(US10562902, Compound 92 | US10562902, Compound 98)
Show SMILES Cc1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2ccccc2)sn1
Show InChI InChI=1S/C21H21N5O2S/c1-14-13-18(29-25-14)23-21-22-17-7-10-26(15-5-3-2-4-6-15)19(17)20(24-21)28-16-8-11-27-12-9-16/h2-7,10,13,16H,8-9,11-12H2,1H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434709
PNG
(US10562902, Compound 115)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnoc3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C17H17N7O3/c1-23-8-12(7-18-23)24-4-2-14-15(24)16(27-13-3-5-25-10-13)22-17(21-14)20-11-6-19-26-9-11/h2,4,6-9,13H,3,5,10H2,1H3,(H,20,21,22)/t13-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434710
PNG
(US10562902, Compound 116 | US10562902, Compound 11...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccccc3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C20H20N6O2/c1-25-12-15(11-21-25)26-9-7-17-18(26)19(28-16-8-10-27-13-16)24-20(23-17)22-14-5-3-2-4-6-14/h2-7,9,11-12,16H,8,10,13H2,1H3,(H,22,23,24)/t16-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434718
PNG
(US10562902, Compound 124)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc4cn[nH]c4c3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C21H20N8O2/c1-28-11-15(10-23-28)29-6-4-17-19(29)20(31-16-5-7-30-12-16)26-21(25-17)24-14-3-2-13-9-22-27-18(13)8-14/h2-4,6,8-11,16H,5,7,12H2,1H3,(H,22,27)(H,24,25,26)/t16-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434614
PNG
(US10562902, Compound 20)
Show SMILES Cc1cc(Nc2nc(N[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C18H20N8OS/c1-11-7-15(28-24-11)22-18-21-14-3-5-26(13-8-19-25(2)9-13)16(14)17(23-18)20-12-4-6-27-10-12/h3,5,7-9,12H,4,6,10H2,1-2H3,(H2,20,21,22,23)/t12-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434618
PNG
(US10562902, Compound 24)
Show SMILES Cc1cc(Nc2nc(N[C@H]3CC[C@](C)(O)CC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C21H26N8OS/c1-13-10-17(31-27-13)25-20-24-16-6-9-29(15-11-22-28(3)12-15)18(16)19(26-20)23-14-4-7-21(2,30)8-5-14/h6,9-12,14,30H,4-5,7-8H2,1-3H3,(H2,23,24,25,26)/t14-,21-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434626
PNG
(US10562902, Compound 32)
Show SMILES CC(=C)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(c3)C3CCOCC3)c12
Show InChI InChI=1S/C21H24N8OS/c1-13(2)23-20-19-17(24-21(26-20)25-18-10-14(3)27-31-18)4-7-28(19)16-11-22-29(12-16)15-5-8-30-9-6-15/h4,7,10-12,15H,1,5-6,8-9H2,2-3H3,(H2,23,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434640
PNG
(US10562902, Compound 46)
Show SMILES C[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cc(C)nn2)nc2ccn(-c3cnn(C)c3)c12
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434644
PNG
(US10562902, Compound 50 | US10562902, Compound 52)
Show SMILES CN(C)C(=O)c1csc(Nc2nc(NC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H26N8O2S/c1-28(2)21(31)14-10-18(33-13-14)26-22-25-17-4-7-30(16-11-23-29(3)12-16)19(17)20(27-22)24-15-5-8-32-9-6-15/h4,7,10-13,15H,5-6,8-9H2,1-3H3,(H2,24,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434677
PNG
(US10562902, Compound 83)
Show SMILES Cc1cc(Nc2nc(O[C@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)on1
Show InChI InChI=1S/C18H19N7O3/c1-11-7-15(28-23-11)21-18-20-14-3-5-25(12-8-19-24(2)9-12)16(14)17(22-18)27-13-4-6-26-10-13/h3,5,7-9,13H,4,6,10H2,1-2H3,(H,20,21,22)/t13-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434682
PNG
(US10562902, Compound 88)
Show SMILES Cc1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2ccoc2)sn1
Show InChI InChI=1S/C19H19N5O3S/c1-12-10-16(28-23-12)21-19-20-15-2-6-24(13-3-7-26-11-13)17(15)18(22-19)27-14-4-8-25-9-5-14/h2-3,6-7,10-11,14H,4-5,8-9H2,1H3,(H,20,21,22)
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n/an/a 550n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434683
PNG
(US10562902, Compound 89)
Show SMILES Cc1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2ccsc2)sn1
Show InChI InChI=1S/C19H19N5O2S2/c1-12-10-16(28-23-12)21-19-20-15-2-6-24(13-5-9-27-11-13)17(15)18(22-19)26-14-3-7-25-8-4-14/h2,5-6,9-11,14H,3-4,7-8H2,1H3,(H,20,21,22)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434744
PNG
(US10562902, Compound 150 | US10562902, Compound 15...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)N3CCCCC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C24H27N7O3S/c1-29-13-17(12-25-29)31-9-5-19-21(31)22(34-18-6-10-33-14-18)28-24(26-19)27-20-11-16(15-35-20)23(32)30-7-3-2-4-8-30/h5,9,11-13,15,18H,2-4,6-8,10,14H2,1H3,(H,26,27,28)/t18-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434597
PNG
(US10562902, Compound 3)
Show SMILES Cc1cc(Nc2nc(NCCO)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C16H18N8OS/c1-10-7-13(26-22-10)20-16-19-12-3-5-24(11-8-18-23(2)9-11)14(12)15(21-16)17-4-6-25/h3,5,7-9,25H,4,6H2,1-2H3,(H2,17,19,20,21)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434628
PNG
(US10562902, Compound 34)
Show SMILES Cc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c3n(ccc3n2)-c2ccc(F)cc2)sn1
Show InChI InChI=1S/C22H23FN6OS/c1-13-12-19(31-28-13)26-22-25-18-10-11-29(16-6-2-14(23)3-7-16)20(18)21(27-22)24-15-4-8-17(30)9-5-15/h2-3,6-7,10-12,15,17,30H,4-5,8-9H2,1H3,(H2,24,25,26,27)/t15-,17-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434651
PNG
(US10562902, Compound 57)
Show SMILES Cc1cc(Nc2nc(OCCCO)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C17H19N7O2S/c1-11-8-14(27-22-11)20-17-19-13-4-5-24(12-9-18-23(2)10-12)15(13)16(21-17)26-7-3-6-25/h4-5,8-10,25H,3,6-7H2,1-2H3,(H,19,20,21)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434653
PNG
(US10562902, Compound 59)
Show SMILES Cc1cc(Nc2nc(OCc3ccccn3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H18N8OS/c1-13-9-17(30-26-13)24-20-23-16-6-8-28(15-10-22-27(2)11-15)18(16)19(25-20)29-12-14-5-3-4-7-21-14/h3-11H,12H2,1-2H3,(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434667
PNG
(US10562902, Compound 73)
Show SMILES CC(=C)N1CCC(CC1)Oc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C22H26N8OS/c1-14(2)29-8-5-17(6-9-29)31-21-20-18(7-10-30(20)16-12-23-28(4)13-16)24-22(26-21)25-19-11-15(3)27-32-19/h7,10-13,17H,1,5-6,8-9H2,2-4H3,(H,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434670
PNG
(US10562902, Compound 76)
Show SMILES Cc1cc(Nc2nc(OC3CCS(=O)(=O)CC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H21N7O3S2/c1-12-9-16(30-24-12)22-19-21-15-3-6-26(13-10-20-25(2)11-13)17(15)18(23-19)29-14-4-7-31(27,28)8-5-14/h3,6,9-11,14H,4-5,7-8H2,1-2H3,(H,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434695
PNG
(US10562902, Compound 101)
Show SMILES COc1cc(ccn1)-n1ccc2nc(Nc3cc(C)ns3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C21H22N6O3S/c1-13-11-18(31-26-13)24-21-23-16-4-8-27(14-3-7-22-17(12-14)28-2)19(16)20(25-21)30-15-5-9-29-10-6-15/h3-4,7-8,11-12,15H,5-6,9-10H2,1-2H3,(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434697
PNG
(US10562902, Compound 103)
Show SMILES Cc1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2cncnc2)sn1
Show InChI InChI=1S/C19H19N7O2S/c1-12-8-16(29-25-12)23-19-22-15-2-5-26(13-9-20-11-21-10-13)17(15)18(24-19)28-14-3-6-27-7-4-14/h2,5,8-11,14H,3-4,6-7H2,1H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434706
PNG
(US10562902, Compound 112 | US10562902, Compound 11...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnn(c3)-c3ccccc3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C23H22N8O2/c1-29-14-18(12-24-29)30-9-7-20-21(30)22(33-19-8-10-32-15-19)28-23(27-20)26-16-11-25-31(13-16)17-5-3-2-4-6-17/h2-7,9,11-14,19H,8,10,15H2,1H3,(H,26,27,28)/t19-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434723
PNG
(US10562902, Compound 129)
Show SMILES CNC(=O)c1csc(Nc2nc(OC3CCCCC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H25N7O2S/c1-23-20(30)14-10-18(32-13-14)26-22-25-17-8-9-29(15-11-24-28(2)12-15)19(17)21(27-22)31-16-6-4-3-5-7-16/h8-13,16H,3-7H2,1-2H3,(H,23,30)(H,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434729
PNG
(US10562902, Compound 135)
Show SMILES CCCNC(=O)c1csc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H25N7O3S/c1-3-6-23-20(30)14-9-18(33-13-14)26-22-25-17-4-7-29(15-10-24-28(2)11-15)19(17)21(27-22)32-16-5-8-31-12-16/h4,7,9-11,13,16H,3,5-6,8,12H2,1-2H3,(H,23,30)(H,25,26,27)/t16-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434738
PNG
(US10562902, Compound 144)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cc(cs3)C(=O)NC3CCCCC3)nc(O[C@@H]3CCOC3)c12
Show InChI InChI=1S/C25H29N7O3S/c1-31-13-18(12-26-31)32-9-7-20-22(32)24(35-19-8-10-34-14-19)30-25(28-20)29-21-11-16(15-36-21)23(33)27-17-5-3-2-4-6-17/h7,9,11-13,15,17,19H,2-6,8,10,14H2,1H3,(H,27,33)(H,28,29,30)/t19-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434603
PNG
(US10562902, Compound 9)
Show SMILES CC(=O)NCCCNc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C19H23N9OS/c1-12-9-16(30-26-12)24-19-23-15-5-8-28(14-10-22-27(3)11-14)17(15)18(25-19)21-7-4-6-20-13(2)29/h5,8-11H,4,6-7H2,1-3H3,(H,20,29)(H2,21,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434615
PNG
(US10562902, Compound 21)
Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C18H20N8OS/c1-11-7-15(28-24-11)22-18-21-14-3-5-26(13-8-19-25(2)9-13)16(14)17(23-18)20-12-4-6-27-10-12/h3,5,7-9,12H,4,6,10H2,1-2H3,(H2,20,21,22,23)/t12-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434622
PNG
(US10562902, Compound 28)
Show SMILES Cc1cc(Nc2nc(N[C@H]3CC[C@H](N)CC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H25N9S/c1-12-9-17(30-27-12)25-20-24-16-7-8-29(15-10-22-28(2)11-15)18(16)19(26-20)23-14-5-3-13(21)4-6-14/h7-11,13-14H,3-6,21H2,1-2H3,(H2,23,24,25,26)/t13-,14-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434647
PNG
(US10562902, Compound 53)
Show SMILES CN(C1CCOCC1)c1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C20H24N8OS/c1-13-10-17(30-25-13)23-20-22-16-4-7-28(15-11-21-26(2)12-15)18(16)19(24-20)27(3)14-5-8-29-9-6-14/h4,7,10-12,14H,5-6,8-9H2,1-3H3,(H,22,23,24)
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n/an/a 550n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434673
PNG
(US10562902, Compound 79)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3csc(c3)C#N)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C19H17N7O2S/c1-25-9-13(8-21-25)26-4-2-16-17(26)18(28-14-3-5-27-10-14)24-19(23-16)22-12-6-15(7-20)29-11-12/h2,4,6,8-9,11,14H,3,5,10H2,1H3,(H,22,23,24)/t14-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434703
PNG
(US10562902, Compound 109)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3cnn(c3)C3CCCCC3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C23H28N8O2/c1-29-14-18(12-24-29)30-9-7-20-21(30)22(33-19-8-10-32-15-19)28-23(27-20)26-16-11-25-31(13-16)17-5-3-2-4-6-17/h7,9,11-14,17,19H,2-6,8,10,15H2,1H3,(H,26,27,28)/t19-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434768
PNG
(US10562902, Compound 174)
Show SMILES CN(C)C(=O)c1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C22H25N7O3S/c1-27(2)21(30)18-10-14(13-33-18)24-22-25-17-4-7-29(15-11-23-28(3)12-15)19(17)20(26-22)32-16-5-8-31-9-6-16/h4,7,10-13,16H,5-6,8-9H2,1-3H3,(H,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434601
PNG
(US10562902, Compound 7)
Show SMILES CNC(=O)CCCNc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C19H23N9OS/c1-12-9-16(30-26-12)24-19-23-14-6-8-28(13-10-22-27(3)11-13)17(14)18(25-19)21-7-4-5-15(29)20-2/h6,8-11H,4-5,7H2,1-3H3,(H,20,29)(H2,21,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434602
PNG
(US10562902, Compound 8)
Show SMILES CC(=O)NCCNc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C18H21N9OS/c1-11-8-15(29-25-11)23-18-22-14-4-7-27(13-9-21-26(3)10-13)16(14)17(24-18)20-6-5-19-12(2)28/h4,7-10H,5-6H2,1-3H3,(H,19,28)(H2,20,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434611
PNG
(US10562902, Compound 17)
Show SMILES Cc1cc(Nc2nc(NC3CCCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H22N8S/c1-12-9-16(28-25-12)23-19-22-15-7-8-27(14-10-20-26(2)11-14)17(15)18(24-19)21-13-5-3-4-6-13/h7-11,13H,3-6H2,1-2H3,(H2,21,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434617
PNG
(US10562902, Compound 23)
Show SMILES Cc1cc(Nc2nc(NC3CCC(=O)CC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H22N8OS/c1-12-9-17(30-26-12)24-20-23-16-7-8-28(14-10-21-27(2)11-14)18(16)19(25-20)22-13-3-5-15(29)6-4-13/h7-11,13H,3-6H2,1-2H3,(H2,22,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434619
PNG
(US10562902, Compound 25)
Show SMILES CO[C@@H]1CC[C@@H](CC1)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C21H26N8OS/c1-13-10-18(31-27-13)25-21-24-17-8-9-29(15-11-22-28(2)12-15)19(17)20(26-21)23-14-4-6-16(30-3)7-5-14/h8-12,14,16H,4-7H2,1-3H3,(H2,23,24,25,26)/t14-,16+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434621
PNG
(US10562902, Compound 27)
Show SMILES CC(=C)N[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C23H29N9S/c1-14(2)25-16-5-7-17(8-6-16)26-22-21-19(9-10-32(21)18-12-24-31(4)13-18)27-23(29-22)28-20-11-15(3)30-33-20/h9-13,16-17,25H,1,5-8H2,2-4H3,(H2,26,27,28,29)/t16-,17-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434624
PNG
(US10562902, Compound 30)
Show SMILES C[O]1CCC(CC1)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C20H25N8OS/c1-13-10-17(30-26-13)24-20-23-16-4-7-28(15-11-21-27(2)12-15)18(16)19(25-20)22-14-5-8-29(3)9-6-14/h4,7,10-12,14H,5-6,8-9H2,1-3H3,(H2,22,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434625
PNG
(US10562902, Compound 31)
Show SMILES Cc1cc(Nc2nc(Nc3ccc(cc3)C(N)=O)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C21H19N9OS/c1-12-9-17(32-28-12)26-21-25-16-7-8-30(15-10-23-29(2)11-15)18(16)20(27-21)24-14-5-3-13(4-6-14)19(22)31/h3-11H,1-2H3,(H2,22,31)(H2,24,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434634
PNG
(US10562902, Compound 40)
Show SMILES Cc1cc(Nc2nc(NC3CCOCC3)c3n(ccc3n2)-c2ccccc2)sn1
Show InChI InChI=1S/C21H22N6OS/c1-14-13-18(29-26-14)24-21-23-17-7-10-27(16-5-3-2-4-6-16)19(17)20(25-21)22-15-8-11-28-12-9-15/h2-7,10,13,15H,8-9,11-12H2,1H3,(H2,22,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434654
PNG
(US10562902, Compound 60)
Show SMILES CCC(C)Oc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C18H21N7OS/c1-5-12(3)26-17-16-14(6-7-25(16)13-9-19-24(4)10-13)20-18(22-17)21-15-8-11(2)23-27-15/h6-10,12H,5H2,1-4H3,(H,20,21,22)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434657
PNG
(US10562902, Compound 63)
Show SMILES Cc1cc(Nc2nc(OC3CCCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H21N7OS/c1-12-9-16(28-24-12)22-19-21-15-7-8-26(13-10-20-25(2)11-13)17(15)18(23-19)27-14-5-3-4-6-14/h7-11,14H,3-6H2,1-2H3,(H,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434661
PNG
(US10562902, Compound 67)
Show SMILES Cc1cc(Nc2nc(OC3CCC(O)CC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C20H23N7O2S/c1-12-9-17(30-25-12)23-20-22-16-7-8-27(13-10-21-26(2)11-13)18(16)19(24-20)29-15-5-3-14(28)4-6-15/h7-11,14-15,28H,3-6H2,1-2H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434662
PNG
(US10562902, Compound 68)
Show SMILES COC1CCC(CC1)Oc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C21H25N7O2S/c1-13-10-18(31-26-13)24-21-23-17-8-9-28(14-11-22-27(2)12-14)19(17)20(25-21)30-16-6-4-15(29-3)5-7-16/h8-12,15-16H,4-7H2,1-3H3,(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434669
PNG
(US10562902, Compound 75)
Show SMILES Cc1cc(Nc2nc(OC3CCSCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C19H21N7OS2/c1-12-9-16(29-24-12)22-19-21-15-3-6-26(13-10-20-25(2)11-13)17(15)18(23-19)27-14-4-7-28-8-5-14/h3,6,9-11,14H,4-5,7-8H2,1-2H3,(H,21,22,23)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434686
PNG
(US10562902, Compound 92 | US10562902, Compound 98)
Show SMILES Cc1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2ccccc2)sn1
Show InChI InChI=1S/C21H21N5O2S/c1-14-13-18(29-25-14)23-21-22-17-7-10-26(15-5-3-2-4-6-15)19(17)20(24-21)28-16-8-11-27-12-9-16/h2-7,10,13,16H,8-9,11-12H2,1H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434693
PNG
(US10562902, Compound 99)
Show SMILES COc1cncc(c1)-n1ccc2nc(Nc3cc(C)ns3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C21H22N6O3S/c1-13-9-18(31-26-13)24-21-23-17-3-6-27(14-10-16(28-2)12-22-11-14)19(17)20(25-21)30-15-4-7-29-8-5-15/h3,6,9-12,15H,4-5,7-8H2,1-2H3,(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434610
PNG
(US10562902, Compound 16)
Show SMILES Cc1cc(Nc2nc(N[C@H]3C[C@@H](C3)C3CCCCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C24H30N8S/c1-15-10-21(33-30-15)28-24-27-20-8-9-32(19-13-25-31(2)14-19)22(20)23(29-24)26-18-11-17(12-18)16-6-4-3-5-7-16/h8-10,13-14,16-18H,3-7,11-12H2,1-2H3,(H2,26,27,28,29)/t17-,18-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434627
PNG
(US10562902, Compound 33)
Show SMILES C[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3ccccc3)c12
Show InChI InChI=1S/C23H26N6S/c1-15-8-10-17(11-9-15)24-22-21-19(12-13-29(21)18-6-4-3-5-7-18)25-23(27-22)26-20-14-16(2)28-30-20/h3-7,12-15,17H,8-11H2,1-2H3,(H2,24,25,26,27)/t15-,17-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434641
PNG
(US10562902, Compound 47)
Show SMILES CC(C)Nc1nc(Nc2cc(C)nn2)nc2ccn(-c3cnn(c3)C3CCOCC3)c12
Show InChI InChI=1S/C21H26N9O/c1-13(2)23-20-19-17(24-21(26-20)25-18-10-14(3)27-28-18)4-7-29(19)16-11-22-30(12-16)15-5-8-31-9-6-15/h4,7,10-13,15H,5-6,8-9H2,1-3H3,(H2,23,24,25,26,28)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434664
PNG
(US10562902, Compound 70)
Show SMILES CC(=C)N1CCCC(C1)Oc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C22H26N8OS/c1-14(2)29-8-5-6-17(13-29)31-21-20-18(7-9-30(20)16-11-23-28(4)12-16)24-22(26-21)25-19-10-15(3)27-32-19/h7,9-12,17H,1,5-6,8,13H2,2-4H3,(H,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434666
PNG
(US10562902, Compound 72)
Show SMILES CN1CCC(CC1)Oc1nc(Nc2cc(C)ns2)nc2ccn(-c3cnn(C)c3)c12
Show InChI InChI=1S/C20H24N8OS/c1-13-10-17(30-25-13)23-20-22-16-6-9-28(14-11-21-27(3)12-14)18(16)19(24-20)29-15-4-7-26(2)8-5-15/h6,9-12,15H,4-5,7-8H2,1-3H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434691
PNG
(US10562902, Compound 97)
Show SMILES Cc1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2ccncc2)sn1
Show InChI InChI=1S/C20H20N6O2S/c1-13-12-17(29-25-13)23-20-22-16-4-9-26(14-2-7-21-8-3-14)18(16)19(24-20)28-15-5-10-27-11-6-15/h2-4,7-9,12,15H,5-6,10-11H2,1H3,(H,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434698
PNG
(US10562902, Compound 104)
Show SMILES Cc1cc(Nc2nc(OC3CCOCC3)c3n(ccc3n2)-c2cccc3OCCOc23)sn1
Show InChI InChI=1S/C23H23N5O4S/c1-14-13-19(33-27-14)25-23-24-16-5-8-28(17-3-2-4-18-21(17)31-12-11-30-18)20(16)22(26-23)32-15-6-9-29-10-7-15/h2-5,8,13,15H,6-7,9-12H2,1H3,(H,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434713
PNG
(US10562902, Compound 119)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccc(cc3)C(=O)N3CCOCC3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C25H27N7O4/c1-30-15-19(14-26-30)32-8-6-21-22(32)23(36-20-7-11-35-16-20)29-25(28-21)27-18-4-2-17(3-5-18)24(33)31-9-12-34-13-10-31/h2-6,8,14-15,20H,7,9-13,16H2,1H3,(H,27,28,29)/t20-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434605
PNG
(US10562902, Compound 11)
Show SMILES Cc1cc(Nc2nc(NCCCN3CCCCC3)c3n(ccc3n2)-c2cnn(C)c2)sn1
Show InChI InChI=1S/C22H29N9S/c1-16-13-19(32-28-16)26-22-25-18-7-12-31(17-14-24-29(2)15-17)20(18)21(27-22)23-8-6-11-30-9-4-3-5-10-30/h7,12-15H,3-6,8-11H2,1-2H3,(H2,23,25,26,27)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434688
PNG
(US10562902, Compound 94)
Show SMILES COc1cccc(c1)-n1ccc2nc(Nc3cc(C)ns3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C22H23N5O3S/c1-14-12-19(31-26-14)24-22-23-18-6-9-27(15-4-3-5-17(13-15)28-2)20(18)21(25-22)30-16-7-10-29-11-8-16/h3-6,9,12-13,16H,7-8,10-11H2,1-2H3,(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434689
PNG
(US10562902, Compound 95)
Show SMILES COc1ccc(cc1)-n1ccc2nc(Nc3cc(C)ns3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C22H23N5O3S/c1-14-13-19(31-26-14)24-22-23-18-7-10-27(15-3-5-16(28-2)6-4-15)20(18)21(25-22)30-17-8-11-29-12-9-17/h3-7,10,13,17H,8-9,11-12H2,1-2H3,(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434710
PNG
(US10562902, Compound 116 | US10562902, Compound 11...)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3ccccc3)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C20H20N6O2/c1-25-12-15(11-21-25)26-9-7-17-18(26)19(28-16-8-10-27-13-16)24-20(23-17)22-14-5-3-2-4-6-14/h2-7,9,11-12,16H,8,10,13H2,1H3,(H,22,23,24)/t16-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434633
PNG
(US10562902, Compound 39)
Show SMILES CC(C)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3ccc(N)nc3)c12
Show InChI InChI=1S/C18H20N8S/c1-10(2)21-17-16-13(6-7-26(16)12-4-5-14(19)20-9-12)22-18(24-17)23-15-8-11(3)25-27-15/h4-10H,1-3H3,(H2,19,20)(H2,21,22,23,24)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434687
PNG
(US10562902, Compound 93)
Show SMILES COc1ccccc1-n1ccc2nc(Nc3cc(C)ns3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C22H23N5O3S/c1-14-13-19(31-26-14)24-22-23-16-7-10-27(17-5-3-4-6-18(17)28-2)20(16)21(25-22)30-15-8-11-29-12-9-15/h3-7,10,13,15H,8-9,11-12H2,1-2H3,(H,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434679
PNG
(US10562902, Compound 85)
Show SMILES Cn1cc(cn1)-n1ccc2nc(Nc3csc4ccccc34)nc(O[C@H]3CCOC3)c12
Show InChI InChI=1S/C22H20N6O2S/c1-27-11-14(10-23-27)28-8-6-17-20(28)21(30-15-7-9-29-12-15)26-22(24-17)25-18-13-31-19-5-3-2-4-16(18)19/h2-6,8,10-11,13,15H,7,9,12H2,1H3,(H,24,25,26)/t15-/m0/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434690
PNG
(US10562902, Compound 96)
Show SMILES C[O](C)c1ccc(cc1)-n1ccc2nc(Nc3cc(C)ns3)nc(OC3CCOCC3)c12
Show InChI InChI=1S/C23H26N5O3S/c1-15-14-20(32-27-15)25-23-24-19-8-11-28(16-4-6-18(7-5-16)31(2)3)21(19)22(26-23)30-17-9-12-29-13-10-17/h4-8,11,14,17H,9-10,12-13H2,1-3H3,(H,24,25,26)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434759
PNG
(US10562902, Compound 165)
Show SMILES CNC(=O)c1nc(Nc2nc(O[C@@H]3CCOC3)c3n(ccc3n2)-c2cnn(C)c2)cs1
Show InChI InChI=1S/C19H20N8O3S/c1-20-16(28)18-23-14(10-31-18)24-19-22-13-3-5-27(11-7-21-26(2)8-11)15(13)17(25-19)30-12-4-6-29-9-12/h3,5,7-8,10,12H,4,6,9H2,1-2H3,(H,20,28)(H,22,24,25)/t12-/m1/s1
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434629
PNG
(US10562902, Compound 35)
Show SMILES CC(C)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cccc(c3)C(O)=C)c12
Show InChI InChI=1S/C21H22N6OS/c1-12(2)22-20-19-17(23-21(25-20)24-18-10-13(3)26-29-18)8-9-27(19)16-7-5-6-15(11-16)14(4)28/h5-12,28H,4H2,1-3H3,(H2,22,23,24,25)
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434638
PNG
(US10562902, Compound 44)
Show SMILES CC(C)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cccc4n(C)ncc34)c12
Show InChI InChI=1S/C21H22N8S/c1-12(2)23-20-19-15(24-21(26-20)25-18-10-13(3)27-30-18)8-9-29(19)17-7-5-6-16-14(17)11-22-28(16)4/h5-12H,1-4H3,(H2,23,24,25,26)
PDB
MMDB

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UniProtKB/SwissProt
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US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM434630
PNG
(US10562902, Compound 36)
Show SMILES CC(C)Nc1nc(Nc2cc(C)ns2)nc2ccn(-c3cccc(c3)S(C)(=O)=O)c12
Show InChI InChI=1S/C20H22N6O2S2/c1-12(2)21-19-18-16(22-20(24-19)23-17-10-13(3)25-29-17)8-9-26(18)14-6-5-7-15(11-14)30(4,27)28/h5-12H,1-4H3,(H2,21,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
IRAK4 kinase (purchased from Life Technologies, Cat. No.: PR5612U) was diluted to 2 folds of the final concentration (the final concentration is 0.76...


US Patent US10562902 (2020)


BindingDB Entry DOI: 10.7270/Q2WQ0663
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%