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Patent code US10562910

Compile Data Set for Download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434771
PNG
(US10562910, Example 2)
Show SMILES OC(=O)c1ccc2OCc3nc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)ccc3Oc2c1
Show InChI InChI=1S/C26H18Cl2N2O6/c27-16-2-1-3-17(28)23(16)24-15(25(36-30-24)13-4-5-13)11-34-22-9-8-19-18(29-22)12-33-20-7-6-14(26(31)32)10-21(20)35-19/h1-3,6-10,13H,4-5,11-12H2,(H,31,32)
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n/an/an/an/a 5.10n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434774
PNG
(US10562910, Example 14)
Show SMILES CC1=Cc2ccc(cc2Oc2ccc(OCc3c(onc3-c3c(Cl)cccc3Cl)C3CC3)nc12)C(O)=O
Show InChI InChI=1S/C28H20Cl2N2O5/c1-14-11-16-7-8-17(28(33)34)12-22(16)36-21-9-10-23(31-25(14)21)35-13-18-26(32-37-27(18)15-5-6-15)24-19(29)3-2-4-20(24)30/h2-4,7-12,15H,5-6,13H2,1H3,(H,33,34)
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n/an/an/an/a 15.5n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434770
PNG
(US10562910, Example 1)
Show SMILES OC(=O)c1ccc2c(Oc3ccc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)nc3C=C2F)c1
Show InChI InChI=1S/C27H17Cl2FN2O5/c28-17-2-1-3-18(29)24(17)25-16(26(37-32-25)13-4-5-13)12-35-23-9-8-21-20(31-23)11-19(30)15-7-6-14(27(33)34)10-22(15)36-21/h1-3,6-11,13H,4-5,12H2,(H,33,34)
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n/an/an/an/a 49.3n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434777
PNG
(US10562910, Example 4)
Show SMILES OC(=O)c1cc(F)c2CCc3nc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)ccc3Oc2c1
Show InChI InChI=1S/C27H19Cl2FN2O5/c28-17-2-1-3-18(29)24(17)25-16(26(37-32-25)13-4-5-13)12-35-23-9-8-21-20(31-23)7-6-15-19(30)10-14(27(33)34)11-22(15)36-21/h1-3,8-11,13H,4-7,12H2,(H,33,34)
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n/an/an/an/a 60.4n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434773
PNG
(US10562910, Example 13)
Show SMILES CC1Cc2ccc(cc2Oc2ccc(OCc3c(onc3-c3c(Cl)cccc3Cl)C3CC3)nc12)C(O)=O
Show InChI InChI=1S/C28H22Cl2N2O5/c1-14-11-16-7-8-17(28(33)34)12-22(16)36-21-9-10-23(31-25(14)21)35-13-18-26(32-37-27(18)15-5-6-15)24-19(29)3-2-4-20(24)30/h2-4,7-10,12,14-15H,5-6,11,13H2,1H3,(H,33,34)
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n/an/an/an/a 19.5n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434778
PNG
(US10562910, Example 3)
Show SMILES OC(=O)c1ccc2C3CC3c3nc(OCc4c(noc4C4CC4)-c4c(Cl)cccc4Cl)ccc3Oc2c1
Show InChI InChI=1S/C28H20Cl2N2O5/c29-19-2-1-3-20(30)24(19)26-18(27(37-32-26)13-4-5-13)12-35-23-9-8-21-25(31-23)17-11-16(17)15-7-6-14(28(33)34)10-22(15)36-21/h1-3,6-10,13,16-17H,4-5,11-12H2,(H,33,34)
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n/an/an/an/a 76.1n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434775
PNG
(US10562910, Example 6)
Show SMILES OC(=O)c1cc2Oc3ccc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)nc3CCc2cc1F
Show InChI InChI=1S/C27H19Cl2FN2O5/c28-17-2-1-3-18(29)24(17)25-16(26(37-32-25)13-4-5-13)12-35-23-9-8-21-20(31-23)7-6-14-10-19(30)15(27(33)34)11-22(14)36-21/h1-3,8-11,13H,4-7,12H2,(H,33,34)
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n/an/an/an/a 31n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434772
PNG
(US10562910, Example 11)
Show SMILES OC(=O)c1cc2Oc3ccc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)nc3CCc2cc1O
Show InChI InChI=1S/C27H20Cl2N2O6/c28-17-2-1-3-18(29)24(17)25-16(26(37-31-25)13-4-5-13)12-35-23-9-8-21-19(30-23)7-6-14-10-20(32)15(27(33)34)11-22(14)36-21/h1-3,8-11,13,32H,4-7,12H2,(H,33,34)
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n/an/an/an/a 17n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
Bile acid receptor FXR


(Homo sapiens (Human))
BDBM434776
PNG
(US10562910, Example 5)
Show SMILES OC(=O)c1ccc2C=C(F)c3nc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)ccc3Oc2c1
Show InChI InChI=1S/C27H17Cl2FN2O5/c28-17-2-1-3-18(29)23(17)24-16(26(37-32-24)13-4-5-13)12-35-22-9-8-20-25(31-22)19(30)10-14-6-7-15(27(33)34)11-21(14)36-20/h1-3,6-11,13H,4-5,12H2,(H,33,34)
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n/an/an/an/a 25.7n/an/an/an/a



NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

US Patent


Assay Description
Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...


US Patent US10562910 (2020)


BindingDB Entry DOI: 10.7270/Q2S184WF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%