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Patent code US10562916

Compile Data Set for Download or QSAR

Found 209 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362595
PNG
(US10562916, Compound 155 | US9834564, Compound 155)
Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1cccnc21
Show InChI InChI=1S/C22H18N4/c1-26-19-12-9-16-6-4-14-23-21(16)22(19)25-20(26)13-11-17-10-8-15-5-2-3-7-18(15)24-17/h2-10,12,14H,11,13H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362607
PNG
(US10562916, Compound 167 | US9834564, Compound 167)
Show SMILES Cc1cnc(C)c2ccc(CCc3nc4c5cccnc5ccn4n3)nc12
Show InChI InChI=1S/C21H18N6/c1-13-12-23-14(2)16-7-5-15(24-20(13)16)6-8-19-25-21-17-4-3-10-22-18(17)9-11-27(21)26-19/h3-5,7,9-12H,6,8H2,1-2H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362612
PNG
(US10562916, Compound 172 | US9834564, Compound 172)
Show SMILES Cc1cnc(C)c(CCc2nc(cn2C)-c2ccccc2)n1
Show InChI InChI=1S/C18H20N4/c1-13-11-19-14(2)16(20-13)9-10-18-21-17(12-22(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362616
PNG
(US10562916, Compound 176 | US9834564, Compound 176)
Show SMILES C(Cc1ccc2ncccc2n1)c1nc2c3cccnc3ccn2n1
Show InChI InChI=1S/C19H14N6/c1-3-14-15(20-10-1)9-12-25-19(14)23-18(24-25)8-6-13-5-7-16-17(22-13)4-2-11-21-16/h1-5,7,9-12H,6,8H2
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362637
PNG
(US10562916, Compound 199 | US9834564, Compound 199)
Show SMILES C(Cc1ccc2ncccc2n1)c1cn2ccc3ncccc3c2n1
Show InChI InChI=1S/C20H15N5/c1-3-16-17(21-10-1)9-12-25-13-15(24-20(16)25)6-5-14-7-8-18-19(23-14)4-2-11-22-18/h1-4,7-13H,5-6H2
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362638
PNG
(US10562916, Compound 200 | US9834564, Compound 200)
Show SMILES Cc1ccc2nc(CCc3cn4ccc5ncccc5c4n3)ccc2n1
Show InChI InChI=1S/C21H17N5/c1-14-4-8-20-19(23-14)9-7-15(24-20)5-6-16-13-26-12-10-18-17(21(26)25-16)3-2-11-22-18/h2-4,7-13H,5-6H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50003991
PNG
(CHEMBL2180008 | US10562916, Compound 204 | US98345...)
Show SMILES Cn1c(CCc2ccc3ncccc3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C21H17N5/c1-26-19-10-9-16-15(4-2-12-22-16)21(19)25-20(26)11-7-14-6-8-17-18(24-14)5-3-13-23-17/h2-6,8-10,12-13H,7,11H2,1H3
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PC sid
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362649
PNG
(Compound 211 | US9834564, Compound 211)
Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2c3OCCOc3ccc12
Show InChI InChI=1S/C20H18N4O2/c1-24-16-7-8-17-20(26-11-10-25-17)19(16)23-18(24)9-6-13-12-21-14-4-2-3-5-15(14)22-13/h2-5,7-8,12H,6,9-11H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362429
PNG
(US10562916, Compound 2 | US9834564, Compound 2)
Show SMILES O=c1[nH]c2ccccc2nc1CCc1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C19H16N4O/c24-19-16(21-14-8-4-5-9-15(14)23-19)10-11-18-20-12-17(22-18)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,22)(H,23,24)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362459
PNG
(US10562916, Compound 19 | US9834564, Compound 19)
Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccccc1
Show InChI InChI=1S/C21H19N3/c1-24-15-20(16-7-3-2-4-8-16)23-21(24)14-13-18-12-11-17-9-5-6-10-19(17)22-18/h2-12,15H,13-14H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362460
PNG
(US10562916, Compound 20 | US9834564, Compound 20)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccccc1
Show InChI InChI=1S/C20H18N4/c1-24-14-19(15-7-3-2-4-8-15)23-20(24)12-11-16-13-21-17-9-5-6-10-18(17)22-16/h2-10,13-14H,11-12H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362483
PNG
(US10562916, Compound 43 | US9834564, Compound 43)
Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C21H18FN3/c1-25-14-20(16-6-4-7-17(22)13-16)24-21(25)12-11-18-10-9-15-5-2-3-8-19(15)23-18/h2-10,13-14H,11-12H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362496
PNG
(US10562916, Compound 56 | US9834564, Compound 56)
Show SMILES Cc1cccc(c1)-c1c[nH]c(CCc2nc3ccccc3c(=O)[nH]2)n1
Show InChI InChI=1S/C20H18N4O/c1-13-5-4-6-14(11-13)17-12-21-18(23-17)9-10-19-22-16-8-3-2-7-15(16)20(25)24-19/h2-8,11-12H,9-10H2,1H3,(H,21,23)(H,22,24,25)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362526
PNG
(US10562916, Compound 86 | US9834564, Compound 86)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c(ccc3ncccc23)[nH]1
Show InChI InChI=1S/C21H16N4/c1-2-6-17-14(4-1)7-8-15(23-17)9-12-20-24-19-11-10-18-16(21(19)25-20)5-3-13-22-18/h1-8,10-11,13H,9,12H2,(H,24,25)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362534
PNG
(US10562916, Compound 94 | US9834564, Compound 94)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2cc3ccccc3cc2[nH]1
Show InChI InChI=1S/C21H16N4/c1-2-6-15-12-20-19(11-14(15)5-1)24-21(25-20)10-9-16-13-22-17-7-3-4-8-18(17)23-16/h1-8,11-13H,9-10H2,(H,24,25)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362566
PNG
(US10562916, Compound 126 | US9834564, Compound 126)
Show SMILES Cc1cnc(C)n2nc(CCc3ccc4ccccc4n3)nc12
Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)23-18(12)21-17(22-23)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362575
PNG
(US10562916, Compound 135 | US9834564, Compound 135)
Show SMILES Cc1ccc2ncc(CCc3nc4c(C)ncc(C)n4n3)nc2c1C
Show InChI InChI=1S/C19H20N6/c1-11-5-7-16-18(13(11)3)22-15(10-21-16)6-8-17-23-19-14(4)20-9-12(2)25(19)24-17/h5,7,9-10H,6,8H2,1-4H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362586
PNG
(US10562916, Compound 146 | US9834564, Compound 146)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2ccc3ncccc3n2n1
Show InChI InChI=1S/C20H15N5/c1-2-5-16-14(4-1)7-8-15(22-16)9-11-19-23-20-12-10-17-18(25(20)24-19)6-3-13-21-17/h1-8,10,12-13H,9,11H2
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362593
PNG
(US10562916, Compound 153 | US9834564, Compound 153)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc2c3ncccc3ccn2n1
Show InChI InChI=1S/C20H15N5/c1-2-6-17-14(4-1)7-8-16(22-17)9-10-18-23-20-19-15(5-3-12-21-19)11-13-25(20)24-18/h1-8,11-13H,9-10H2
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362610
PNG
(US10562916, Compound 170 | US9834564, Compound 170)
Show SMILES Cc1cc2ncccc2c2nc(CCc3ccc4ccccc4n3)n(C)c12
Show InChI InChI=1S/C23H20N4/c1-15-14-20-18(7-5-13-24-20)22-23(15)27(2)21(26-22)12-11-17-10-9-16-6-3-4-8-19(16)25-17/h3-10,13-14H,11-12H2,1-2H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362611
PNG
(US10562916, Compound 171 | US9834564, Compound 171)
Show SMILES Cn1c(CCc2ccc3ccc4cccnc4c3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C25H19N5/c1-30-21-12-11-20-19(5-3-14-26-20)25(21)29-22(30)13-10-18-9-8-17-7-6-16-4-2-15-27-23(16)24(17)28-18/h2-9,11-12,14-15H,10,13H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362627
PNG
(US10562916, Compound 189 | US9834564, Compound 189)
Show SMILES C(Cc1cnc2ccccc2n1)c1cn2ccc3ncccc3c2n1
Show InChI InChI=1S/C20H15N5/c1-2-6-19-18(5-1)22-12-14(23-19)7-8-15-13-25-11-9-17-16(20(25)24-15)4-3-10-21-17/h1-6,9-13H,7-8H2
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362630
PNG
(US10562916, Compound 192 | US9834564, Compound 192)
Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2c3CCCNc3ccc12
Show InChI InChI=1S/C21H21N5/c1-26-19-10-9-16-15(5-4-12-22-16)21(19)25-20(26)11-8-14-13-23-17-6-2-3-7-18(17)24-14/h2-3,6-7,9-10,13,22H,4-5,8,11-12H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362444
PNG
(US10562916, Compound 11 | US9834564, Compound 11)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H17N3/c1-2-6-15(7-3-1)19-14-21-20(23-19)13-12-17-11-10-16-8-4-5-9-18(16)22-17/h1-11,14H,12-13H2,(H,21,23)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362456
PNG
(US10562916, Compound 16 | US9834564, Compound 16)
Show SMILES C(Cc1cnc2cccnc2n1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-5-13(6-3-1)16-12-21-17(23-16)9-8-14-11-20-15-7-4-10-19-18(15)22-14/h1-7,10-12H,8-9H2,(H,21,23)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362476
PNG
(US10562916, Compound 36 | US9834564, Compound 36)
Show SMILES C(Cc1cc2ccccc2cn1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H17N3/c1-2-6-15(7-3-1)19-14-22-20(23-19)11-10-18-12-16-8-4-5-9-17(16)13-21-18/h1-9,12-14H,10-11H2,(H,22,23)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362482
PNG
(US10562916, Compound 42 | US9834564, Compound 42)
Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccccc1F
Show InChI InChI=1S/C21H18FN3/c1-25-14-20(17-7-3-4-8-18(17)22)24-21(25)13-12-16-11-10-15-6-2-5-9-19(15)23-16/h2-11,14H,12-13H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362486
PNG
(US10562916, Compound 46 | US9834564, Compound 46)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccsc1
Show InChI InChI=1S/C18H16N4S/c1-22-11-17(13-8-9-23-12-13)21-18(22)7-6-14-10-19-15-4-2-3-5-16(15)20-14/h2-5,8-12H,6-7H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362499
PNG
(US10562916, Compound 59 | US9834564, Compound 59)
Show SMILES Fc1ccccc1-c1c[nH]c(CCc2nc3ccccc3c(=O)[nH]2)n1
Show InChI InChI=1S/C19H15FN4O/c20-14-7-3-1-5-12(14)16-11-21-17(23-16)9-10-18-22-15-8-4-2-6-13(15)19(25)24-18/h1-8,11H,9-10H2,(H,21,23)(H,22,24,25)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362507
PNG
(US10562916, Compound 67 | US9834564, Compound 67)
Show SMILES C(Cc1ccc2ccccc2n1)c1nc(c[nH]1)-c1ccsc1
Show InChI InChI=1S/C18H15N3S/c1-2-4-16-13(3-1)5-6-15(20-16)7-8-18-19-11-17(21-18)14-9-10-22-12-14/h1-6,9-12H,7-8H2,(H,19,21)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362509
PNG
(US10562916, Compound 69 | US9834564, Compound 69)
Show SMILES Fc1ccccc1-c1c[nH]c(CCc2ccc3ccccc3n2)n1
Show InChI InChI=1S/C20H16FN3/c21-17-7-3-2-6-16(17)19-13-22-20(24-19)12-11-15-10-9-14-5-1-4-8-18(14)23-15/h1-10,13H,11-12H2,(H,22,24)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362515
PNG
(US10562916, Compound 75 | US9834564, Compound 75)
Show SMILES Fc1ccccc1-c1c[nH]c(CCc2cnc3ccccc3n2)n1
Show InChI InChI=1S/C19H15FN4/c20-15-6-2-1-5-14(15)18-12-22-19(24-18)10-9-13-11-21-16-7-3-4-8-17(16)23-13/h1-8,11-12H,9-10H2,(H,22,24)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362516
PNG
(US10562916, Compound 76 | US9834564, Compound 76)
Show SMILES Fc1cccc(c1)-c1c[nH]c(CCc2cnc3ccccc3n2)n1
Show InChI InChI=1S/C19H15FN4/c20-14-5-3-4-13(10-14)18-12-22-19(24-18)9-8-15-11-21-16-6-1-2-7-17(16)23-15/h1-7,10-12H,8-9H2,(H,22,24)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362525
PNG
(US10562916, Compound 85 | US9834564, Compound 85)
Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C22H18N4/c1-26-20-12-11-19-17(6-4-14-23-19)22(20)25-21(26)13-10-16-9-8-15-5-2-3-7-18(15)24-16/h2-9,11-12,14H,10,13H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362556
PNG
(US10562916, Compound 116 | US9834564, Compound 116)
Show SMILES O=c1[nH]c(CCc2nc(cs2)-c2ccccc2)nc2ccccc12
Show InChI InChI=1S/C19H15N3OS/c23-19-14-8-4-5-9-15(14)20-17(22-19)10-11-18-21-16(12-24-18)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,22,23)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362577
PNG
(US10562916, Compound 137 | US9834564, Compound 137)
Show SMILES Cc1cnc(C)c2nc(CCc3ccc4ccc5CCCNc5c4n3)nn12
Show InChI InChI=1S/C21H22N6/c1-13-12-23-14(2)21-25-18(26-27(13)21)10-9-17-8-7-16-6-5-15-4-3-11-22-19(15)20(16)24-17/h5-8,12,22H,3-4,9-11H2,1-2H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362578
PNG
(US10562916, Compound 138 | US9834564, Compound 138)
Show SMILES Cc1ncc(C)n2nc(CCc3ccc4cccnc4n3)nc12
Show InChI InChI=1S/C17H16N6/c1-11-10-19-12(2)17-21-15(22-23(11)17)8-7-14-6-5-13-4-3-9-18-16(13)20-14/h3-6,9-10H,7-8H2,1-2H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362594
PNG
(US10562916, Compound 154 | US9834564, Compound 154)
Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2c1ccc1cccnc21
Show InChI InChI=1S/C21H17N5/c1-26-18-10-8-14-5-4-12-22-20(14)21(18)25-19(26)11-9-15-13-23-16-6-2-3-7-17(16)24-15/h2-8,10,12-13H,9,11H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362606
PNG
(US10562916, Compound 166 | US9834564, Compound 166)
Show SMILES Cc1cnc(C)c2ccc(CCc3nc4c(ccc5ncccc45)[nH]3)nc12
Show InChI InChI=1S/C22H19N5/c1-13-12-24-14(2)16-7-5-15(25-21(13)16)6-10-20-26-19-9-8-18-17(22(19)27-20)4-3-11-23-18/h3-5,7-9,11-12H,6,10H2,1-2H3,(H,26,27)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362628
PNG
(US10562916, Compound 190 | US9834564, Compound 190)
Show SMILES Cc1c(CCc2cnc3ccccc3n2)nc2c3cccnc3ccn12
Show InChI InChI=1S/C21H17N5/c1-14-17(9-8-15-13-23-19-6-2-3-7-20(19)24-15)25-21-16-5-4-11-22-18(16)10-12-26(14)21/h2-7,10-13H,8-9H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362631
PNG
(US10562916, Compound 193 | US9834564, Compound 193)
Show SMILES Cc1cc(C)nc(CCc2nc3c(ccc4ncccc34)n2C)n1
Show InChI InChI=1S/C19H19N5/c1-12-11-13(2)22-17(21-12)8-9-18-23-19-14-5-4-10-20-15(14)6-7-16(19)24(18)3/h4-7,10-11H,8-9H2,1-3H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362646
PNG
(US10562916, Compound 208 | US9834564, Compound 208)
Show SMILES Cc1nc(CCc2nc3c(ccc4ncccc34)n2C)nc(C)c1Cl
Show InChI InChI=1S/C19H18ClN5/c1-11-18(20)12(2)23-16(22-11)8-9-17-24-19-13-5-4-10-21-14(13)6-7-15(19)25(17)3/h4-7,10H,8-9H2,1-3H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362485
PNG
(US10562916, Compound 45 | US9834564, Compound 45)
Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccco1
Show InChI InChI=1S/C18H16N4O/c1-22-12-16(17-7-4-10-23-17)21-18(22)9-8-13-11-19-14-5-2-3-6-15(14)20-13/h2-7,10-12H,8-9H2,1H3
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362501
PNG
(US10562916, Compound 61 | US9834564, Compound 61)
Show SMILES Fc1cccc(c1)-c1c[nH]c(CCc2nc3ccccc3c(=O)[nH]2)n1
Show InChI InChI=1S/C19H15FN4O/c20-13-5-3-4-12(10-13)16-11-21-17(23-16)8-9-18-22-15-7-2-1-6-14(15)19(25)24-18/h1-7,10-11H,8-9H2,(H,21,23)(H,22,24,25)
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n/an/a<500n/an/an/an/an/an/a



Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362543
PNG
(US10562916, Compound 103 | US9834564, Compound 103)
Show SMILES C(Cc1cnc2ccccc2n1)c1nc2c(ccc3ccccc23)[nH]1
Show InChI InChI=1S/C21H16N4/c1-2-6-16-14(5-1)9-11-19-21(16)25-20(24-19)12-10-15-13-22-17-7-3-4-8-18(17)23-15/h1-9,11,13H,10,12H2,(H,24,25)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362564
PNG
(US10562916, Compound 124 | US9834564, Compound 124)
Show SMILES S(c1nc(c[nH]1)-c1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C17H12N4S/c1-2-6-12(7-3-1)15-10-19-17(21-15)22-16-11-18-13-8-4-5-9-14(13)20-16/h1-11H,(H,19,21)
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362567
PNG
(US10562916, Compound 127 | US9834564, Compound 127)
Show SMILES Cc1ncc(C)n2nc(CCc3nc4ccccc4cc3F)nc12
Show InChI InChI=1S/C18H16FN5/c1-11-10-20-12(2)18-22-17(23-24(11)18)8-7-16-14(19)9-13-5-3-4-6-15(13)21-16/h3-6,9-10H,7-8H2,1-2H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362571
PNG
(US10562916, Compound 131 | US9834564, Compound 131)
Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccc(F)c(F)c4n3)nc12
Show InChI InChI=1S/C18H15F2N5/c1-10-9-21-11(2)18-23-15(24-25(10)18)8-6-13-5-3-12-4-7-14(19)16(20)17(12)22-13/h3-5,7,9H,6,8H2,1-2H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362574
PNG
(US10562916, Compound 134 | US9834564, Compound 134)
Show SMILES Cc1ncc(C)n2nc(CCc3cnc4ccccc4n3)nc12
Show InChI InChI=1S/C17H16N6/c1-11-9-18-12(2)17-21-16(22-23(11)17)8-7-13-10-19-14-5-3-4-6-15(14)20-13/h3-6,9-10H,7-8H2,1-2H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM362589
PNG
(US10562916, Compound 149 | US9834564, Compound 149)
Show SMILES Cn1c(CCc2cnc3c(Cl)ccc(Cl)c3n2)nc2c1ccc1ncccc21
Show InChI InChI=1S/C21H15Cl2N5/c1-28-17-8-7-16-13(3-2-10-24-16)19(17)27-18(28)9-4-12-11-25-20-14(22)5-6-15(23)21(20)26-12/h2-3,5-8,10-11H,4,9H2,1H3
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Sunovion Pharmaceuticals, Inc.

US Patent


Assay Description
In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...

US Patent US10562916 (2020)


BindingDB Entry DOI: 10.7270/Q2N87D6K
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%