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Patent code US10568876

Compile Data Set for Download or QSAR
Found 141 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435283
PNG
(US10568876, Example 46 | ethyl 5-(2-(tert-butylcar...)
Show SMILES CCOC(=O)c1cncc(c1)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C33H38N4O4/c1-5-41-31(39)24-15-23(17-34-18-24)25-12-11-22(19-35-30(38)28-16-27(28)21-9-7-6-8-10-21)29-20-37(14-13-26(25)29)32(40)36-33(2,3)4/h6-12,15,17-18,27-28H,5,13-14,16,19-20H2,1-4H3,(H,35,38)(H,36,40)/t27-,28?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435291
PNG
(US10568876, Example 54 | methyl 3-(2-((1-methylcyc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)[C@H]2C[C@@H]2c2ccccc2)c2CN(CCc12)C(=O)NC1(C)CC1
Show InChI InChI=1S/C33H35N3O4/c1-33(14-15-33)35-32(39)36-16-13-26-25(22-9-6-10-23(17-22)31(38)40-2)12-11-24(29(26)20-36)19-34-30(37)28-18-27(28)21-7-4-3-5-8-21/h3-12,17,27-28H,13-16,18-20H2,1-2H3,(H,34,37)(H,35,39)/t27-,28+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435252
PNG
(US10568876, Example 17 | methyl 3-(2-(tert-butylca...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC22CCCCC2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C32H41N3O4/c1-31(2,3)34-30(38)35-16-13-25-24(21-9-8-10-22(17-21)29(37)39-4)12-11-23(26(25)20-35)19-33-28(36)27-18-32(27)14-6-5-7-15-32/h8-12,17,27H,5-7,13-16,18-20H2,1-4H3,(H,33,36)(H,34,38)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435246
PNG
(N-(tert-butyl)-5-(3-methoxyphenyl)-8- (((trans)-2-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2nc(C)no2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H35N5O4/c1-17-31-27(38-33-17)24-14-23(24)26(35)30-15-19-9-10-21(18-7-6-8-20(13-18)37-5)22-11-12-34(16-25(19)22)28(36)32-29(2,3)4/h6-10,13,23-24H,11-12,14-16H2,1-5H3,(H,30,35)(H,32,36)/t23-,24-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435236
PNG
(US10568876, Example 1)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H32F3N5O4/c1-16-34-26(41-36-16)23-13-22(23)25(38)33-14-18-8-9-20(17-6-5-7-19(12-17)40-29(30,31)32)21-10-11-37(15-24(18)21)27(39)35-28(2,3)4/h5-9,12,22-23H,10-11,13-15H2,1-4H3,(H,33,38)(H,35,39)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435247
PNG
(N-(tert-butyl)-8-(((trans)-2-(3-methyl- 1,2,4-oxad...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H32F3N5O4/c1-16-34-26(41-36-16)23-13-22(23)25(38)33-14-18-8-9-20(17-6-5-7-19(12-17)40-29(30,31)32)21-10-11-37(15-24(18)21)27(39)35-28(2,3)4/h5-9,12,22-23H,10-11,13-15H2,1-4H3,(H,33,38)(H,35,39)/t22-,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435288
PNG
(5-(3-(1,2,4-oxadiazol-3-yl)phenyl)-N- (tert-butyI)...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)-c1ncon1
Show InChI InChI=1S/C33H35N5O3/c1-33(2,3)36-32(40)38-15-14-26-25(22-10-7-11-23(16-22)30-35-20-41-37-30)13-12-24(29(26)19-38)18-34-31(39)28-17-27(28)21-8-5-4-6-9-21/h4-13,16,20,27-28H,14-15,17-19H2,1-3H3,(H,34,39)(H,36,40)/t27-,28?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435238
PNG
(N-(tert-butyl)-8-(((trans)-2-(3-methyl- 1,2,4-oxad...)
Show SMILES Cc1noc(n1)C1C[C@@H]1C(=O)NCc1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H32F3N5O3/c1-16-34-26(40-36-16)23-13-22(23)25(38)33-14-18-8-9-20(17-6-5-7-19(12-17)29(30,31)32)21-10-11-37(15-24(18)21)27(39)35-28(2,3)4/h5-9,12,22-23H,10-11,13-15H2,1-4H3,(H,33,38)(H,35,39)/t22-,23?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435248
PNG
(N-(tert-butyl)-5-(3-methoxyphenyl)-8- ((2-(pyridin...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2cccnc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C31H36N4O3/c1-31(2,3)34-30(37)35-14-12-25-24(20-7-5-9-23(15-20)38-4)11-10-22(28(25)19-35)18-33-29(36)27-16-26(27)21-8-6-13-32-17-21/h5-11,13,15,17,26-27H,12,14,16,18-19H2,1-4H3,(H,33,36)(H,34,37)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435302
PNG
(5-(3-methoxyphenyl)-8-(((trans)-2-(3- methyl-1,2,4...)
Show SMILES CCCNC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1nc(C)no1)ccc2-c1cccc(OC)c1
Show InChI InChI=1S/C28H33N5O4/c1-4-11-29-28(35)33-12-10-22-21(18-6-5-7-20(13-18)36-3)9-8-19(25(22)16-33)15-30-26(34)23-14-24(23)27-31-17(2)32-37-27/h5-9,13,23-24H,4,10-12,14-16H2,1-3H3,(H,29,35)(H,30,34)/t23-,24-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435255
PNG
(N-(tert-butyl)-5-(3-methoxyphenyl)-8- (((trans)-2-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H]2C[C@@H]2c2cccnc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C31H36N4O3/c1-31(2,3)34-30(37)35-14-12-25-24(20-7-5-9-23(15-20)38-4)11-10-22(28(25)19-35)18-33-29(36)27-16-26(27)21-8-6-13-32-17-21/h5-11,13,15,17,26-27H,12,14,16,18-19H2,1-4H3,(H,33,36)(H,34,37)/t26-,27+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435287
PNG
(5-(3-(1H-1,2,4-triazol-1-yl)phenyl)-N- (tert-butyl...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)-n1cncn1
Show InChI InChI=1S/C33H36N6O2/c1-33(2,3)37-32(41)38-15-14-27-26(23-10-7-11-25(16-23)39-21-34-20-36-39)13-12-24(30(27)19-38)18-35-31(40)29-17-28(29)22-8-5-4-6-9-22/h4-13,16,20-21,28-29H,14-15,17-19H2,1-3H3,(H,35,40)(H,37,41)/t28-,29?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435293
PNG
(US10568876, Example 56 | methyl 3-(2-((3,3-difluor...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)NC1CC(F)(F)C1
Show InChI InChI=1S/C33H33F2N3O4/c1-42-31(40)22-9-5-8-21(14-22)25-11-10-23(18-36-30(39)28-15-27(28)20-6-3-2-4-7-20)29-19-38(13-12-26(25)29)32(41)37-24-16-33(34,35)17-24/h2-11,14,24,27-28H,12-13,15-19H2,1H3,(H,36,39)(H,37,41)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435292
PNG
(US10568876, Example 55 | methyl 3-(2-((1-methylcyc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)NC1(C)CCCC1
Show InChI InChI=1S/C35H39N3O4/c1-35(16-6-7-17-35)37-34(41)38-18-15-28-27(24-11-8-12-25(19-24)33(40)42-2)14-13-26(31(28)22-38)21-36-32(39)30-20-29(30)23-9-4-3-5-10-23/h3-5,8-14,19,29-30H,6-7,15-18,20-22H2,1-2H3,(H,36,39)(H,37,41)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435286
PNG
(5-(3-(1,3,4-oxadiazol-2-yl)phenyl)-N- (tert-butyl)...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)-c1nnco1
Show InChI InChI=1S/C33H35N5O3/c1-33(2,3)36-32(40)38-15-14-26-25(22-10-7-11-23(16-22)31-37-35-20-41-31)13-12-24(29(26)19-38)18-34-30(39)28-17-27(28)21-8-5-4-6-9-21/h4-13,16,20,27-28H,14-15,17-19H2,1-3H3,(H,34,39)(H,36,40)/t27-,28?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435240
PNG
(5-(3-(1H-1,2,3-triazol-1-yl)phenyl)-N- (tert-butyl...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)-n1ccnn1
Show InChI InChI=1S/C33H36N6O2/c1-33(2,3)36-32(41)38-16-14-27-26(23-10-7-11-25(18-23)39-17-15-35-37-39)13-12-24(30(27)21-38)20-34-31(40)29-19-28(29)22-8-5-4-6-9-22/h4-13,15,17-18,28-29H,14,16,19-21H2,1-3H3,(H,34,40)(H,36,41)/t28-,29?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435303
PNG
(8-(((trans)-2-(3-methyl-1,2,4-oxadiazol-5- yl)cycl...)
Show SMILES CCCNC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1nc(C)no1)ccc2-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H30F3N5O3/c1-3-10-32-27(38)36-11-9-21-20(17-5-4-6-19(12-17)28(29,30)31)8-7-18(24(21)15-36)14-33-25(37)22-13-23(22)26-34-16(2)35-39-26/h4-8,12,22-23H,3,9-11,13-15H2,1-2H3,(H,32,38)(H,33,37)/t22-,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435270
PNG
(5-(3-(1H-pyrazol-1-yl)phenyl)-N-(tert- butyl)-8-((...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)-n1cccn1
Show InChI InChI=1S/C34H37N5O2/c1-34(2,3)37-33(41)38-18-15-28-27(24-11-7-12-26(19-24)39-17-8-16-36-39)14-13-25(31(28)22-38)21-35-32(40)30-20-29(30)23-9-5-4-6-10-23/h4-14,16-17,19,29-30H,15,18,20-22H2,1-3H3,(H,35,40)(H,37,41)/t29-,30?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435239
PNG
(N-(tert-butyl)-8-((2-(pyridin-3- yl)cyclopropaneca...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1CC1c1cccnc1)ccc2-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C31H33F3N4O3/c1-30(2,3)37-29(40)38-13-11-24-23(19-6-4-8-22(14-19)41-31(32,33)34)10-9-21(27(24)18-38)17-36-28(39)26-15-25(26)20-7-5-12-35-16-20/h4-10,12,14,16,25-26H,11,13,15,17-18H2,1-3H3,(H,36,39)(H,37,40)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435290
PNG
(US10568876, Example 53)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2nc(C)no2)c2CN(CCc12)C(=O)NC1(C)COC1
Show InChI InChI=1S/C29H33N5O5/c1-17-31-27(39-33-17)24-12-23(24)26(35)30-13-19-7-8-21(18-5-4-6-20(11-18)37-3)22-9-10-34(14-25(19)22)28(36)32-29(2)15-38-16-29/h4-8,11,23-24H,9-10,12-16H2,1-3H3,(H,30,35)(H,32,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435304
PNG
(8-(((trans)-2-(3-methyl-1,2,4-oxadiazol-5- yl)cycl...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC1(C)COC1
Show InChI InChI=1S/C29H30F3N5O5/c1-16-34-26(42-36-16)23-11-22(23)25(38)33-12-18-6-7-20(17-4-3-5-19(10-17)41-29(30,31)32)21-8-9-37(13-24(18)21)27(39)35-28(2)14-40-15-28/h3-7,10,22-23H,8-9,11-15H2,1-2H3,(H,33,38)(H,35,39)/t22-,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435305
PNG
(5-(3-methoxyphenyl)-N-(3-methyloxetan- 3-yl)-8-(((...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2CC2c2ccccc2)c2CN(CCc12)C(=O)NC1(C)COC1
Show InChI InChI=1S/C32H35N3O4/c1-32(19-39-20-32)34-31(37)35-14-13-26-25(22-9-6-10-24(15-22)38-2)12-11-23(29(26)18-35)17-33-30(36)28-16-27(28)21-7-4-3-5-8-21/h3-12,15,27-28H,13-14,16-20H2,1-2H3,(H,33,36)(H,34,37)/t27?,28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435242
PNG
(US10568876, Example 21 | US10568876, Example 7 | m...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2nc(C)no2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C30H35N5O5/c1-17-32-27(40-34-17)24-14-23(24)26(36)31-15-20-9-10-21(18-7-6-8-19(13-18)28(37)39-5)22-11-12-35(16-25(20)22)29(38)33-30(2,3)4/h6-10,13,23-24H,11-12,14-16H2,1-5H3,(H,31,36)(H,33,38)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435242
PNG
(US10568876, Example 21 | US10568876, Example 7 | m...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2nc(C)no2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C30H35N5O5/c1-17-32-27(40-34-17)24-14-23(24)26(36)31-15-20-9-10-21(18-7-6-8-19(13-18)28(37)39-5)22-11-12-35(16-25(20)22)29(38)33-30(2,3)4/h6-10,13,23-24H,11-12,14-16H2,1-5H3,(H,31,36)(H,33,38)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435258
PNG
(N-(tert-butyl)-5-(3-cyanophenyl)-8- (((trans)-2- p...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)C#N
Show InChI InChI=1S/C32H34N4O2/c1-32(2,3)35-31(38)36-15-14-26-25(23-11-7-8-21(16-23)18-33)13-12-24(29(26)20-36)19-34-30(37)28-17-27(28)22-9-5-4-6-10-22/h4-13,16,27-28H,14-15,17,19-20H2,1-3H3,(H,34,37)(H,35,38)/t27-,28+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435306
PNG
(8-(((trans)-2-(3-methyl-1,2,4-oxadiazol-5- yl)cycl...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC1(C)COC1
Show InChI InChI=1S/C29H30F3N5O4/c1-16-34-26(41-36-16)23-11-22(23)25(38)33-12-18-6-7-20(17-4-3-5-19(10-17)29(30,31)32)21-8-9-37(13-24(18)21)27(39)35-28(2)14-40-15-28/h3-7,10,22-23H,8-9,11-15H2,1-2H3,(H,33,38)(H,35,39)/t22-,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435289
PNG
(N-(tert-butyl)-5-(3-(2-hydroxypropan- 2-yl)phenyl)...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)C(C)(C)O
Show InChI InChI=1S/C34H41N3O3/c1-33(2,3)36-32(39)37-17-16-27-26(23-12-9-13-25(18-23)34(4,5)40)15-14-24(30(27)21-37)20-35-31(38)29-19-28(29)22-10-7-6-8-11-22/h6-15,18,28-29,40H,16-17,19-21H2,1-5H3,(H,35,38)(H,36,39)/t28-,29?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435307
PNG
(5-(3-methoxyphenyl)-8-(((trans-2- phenylcyclopropa...)
Show SMILES CCNC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1ccccc1)ccc2-c1cccc(OC)c1
Show InChI InChI=1S/C30H33N3O3/c1-3-31-30(35)33-15-14-25-24(21-10-7-11-23(16-21)36-2)13-12-22(28(25)19-33)18-32-29(34)27-17-26(27)20-8-5-4-6-9-20/h4-13,16,26-27H,3,14-15,17-19H2,1-2H3,(H,31,35)(H,32,34)/t26-,27+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435308
PNG
(N-cyclopropyl-5-(3-methoxyphenyl)-8- (((trans2- ph...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC1CC1
Show InChI InChI=1S/C31H33N3O3/c1-37-24-9-5-8-21(16-24)25-13-10-22(18-32-30(35)28-17-27(28)20-6-3-2-4-7-20)29-19-34(15-14-26(25)29)31(36)33-23-11-12-23/h2-10,13,16,23,27-28H,11-12,14-15,17-19H2,1H3,(H,32,35)(H,33,36)/t27-,28+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435309
PNG
(5-(3-methoxyphenyl)-N-(3-methylbutan-2- yl)-H((tra...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)C(C)C
Show InChI InChI=1S/C33H39N3O3/c1-21(2)22(3)35-33(38)36-16-15-28-27(24-11-8-12-26(17-24)39-4)14-13-25(31(28)20-36)19-34-32(37)30-18-29(30)23-9-6-5-7-10-23/h5-14,17,21-22,29-30H,15-16,18-20H2,1-4H3,(H,34,37)(H,35,38)/t22?,29-,30+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435295
PNG
(N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)-8...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C30H32F3N5O6S/c1-17-35-27(44-37-17)24-13-23(24)26(39)34-14-19-6-7-21(18-4-3-5-20(12-18)43-30(31,32)33)22-8-10-38(15-25(19)22)28(40)36-29(2)9-11-45(41,42)16-29/h3-7,12,23-24H,8-11,13-16H2,1-2H3,(H,34,39)(H,36,40)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435244
PNG
(N-(tert-butyl)-8-(((trans)-2- phenylcyclopropaneca...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)[C@H]1C[C@@H]1c1ccccc1)ccc2-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C32H34F3N3O3/c1-31(2,3)37-30(40)38-15-14-25-24(21-10-7-11-23(16-21)41-32(33,34)35)13-12-22(28(25)19-38)18-36-29(39)27-17-26(27)20-8-5-4-6-9-20/h4-13,16,26-27H,14-15,17-19H2,1-3H3,(H,36,39)(H,37,40)/t26-,27+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435249
PNG
(N-(tert-butyl)-8-(((trans)-2- phenylcyclopropaneca...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C32H34F3N3O2/c1-31(2,3)37-30(40)38-15-14-25-24(21-10-7-11-23(16-21)32(33,34)35)13-12-22(28(25)19-38)18-36-29(39)27-17-26(27)20-8-5-4-6-9-20/h4-13,16,26-27H,14-15,17-19H2,1-3H3,(H,36,39)(H,37,40)/t26-,27+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435310
PNG
(8-(((trans)-2-(3-methyl-1,2,4-oxadiazol-5- yl)cycl...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC1COC1
Show InChI InChI=1S/C28H28F3N5O5/c1-15-33-26(41-35-15)23-10-22(23)25(37)32-11-17-5-6-20(16-3-2-4-19(9-16)40-28(29,30)31)21-7-8-36(12-24(17)21)27(38)34-18-13-39-14-18/h2-6,9,18,22-23H,7-8,10-14H2,1H3,(H,32,37)(H,34,38)/t22-,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435263
PNG
(N-(tert-butyl)-5-(3- methylbenzo[d]isoxazol-5-yl)-...)
Show SMILES Cc1noc2ccc(cc12)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C33H36N4O3/c1-20-26-16-22(11-13-30(26)40-36-20)24-12-10-23(18-34-31(38)28-17-27(28)21-8-6-5-7-9-21)29-19-37(15-14-25(24)29)32(39)35-33(2,3)4/h5-13,16,27-28H,14-15,17-19H2,1-4H3,(H,34,38)(H,35,39)/t27-,28?/m0/s1
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n/an/a 59.8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435243
PNG
(N-(tert-butyl)-5-(5-methylpyridin-3- yl)-8-(((tran...)
Show SMILES Cc1cncc(c1)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C31H36N4O2/c1-20-14-23(17-32-16-20)24-11-10-22(18-33-29(36)27-15-26(27)21-8-6-5-7-9-21)28-19-35(13-12-25(24)28)30(37)34-31(2,3)4/h5-11,14,16-17,26-27H,12-13,15,18-19H2,1-4H3,(H,33,36)(H,34,37)/t26-,27?/m0/s1
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n/an/a 82.3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435294
PNG
(N-(3,3-difluorocyclobutyl)-5-(3- methoxyphenyl)-8-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)NC1CC(F)(F)C1
Show InChI InChI=1S/C32H33F2N3O3/c1-40-24-9-5-8-21(14-24)25-11-10-22(18-35-30(38)28-15-27(28)20-6-3-2-4-7-20)29-19-37(13-12-26(25)29)31(39)36-23-16-32(33,34)17-23/h2-11,14,23,27-28H,12-13,15-19H2,1H3,(H,35,38)(H,36,39)
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n/an/a 87n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435311
PNG
(5-(3-methoxyphenyl)-N-(oxetan-3-yl)-8- (((trans)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC1COC1
Show InChI InChI=1S/C31H33N3O4/c1-37-24-9-5-8-21(14-24)25-11-10-22(16-32-30(35)28-15-27(28)20-6-3-2-4-7-20)29-17-34(13-12-26(25)29)31(36)33-23-18-38-19-23/h2-11,14,23,27-28H,12-13,15-19H2,1H3,(H,32,35)(H,33,36)/t27-,28+/m0/s1
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n/an/a 89.8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435274
PNG
(N-(tert-butyl)-5-(1-isobutyl-1H- pyrazol-4-yl)-8-(...)
Show SMILES CC(C)Cn1cc(cn1)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C32H41N5O2/c1-21(2)18-37-19-24(17-34-37)25-12-11-23(16-33-30(38)28-15-27(28)22-9-7-6-8-10-22)29-20-36(14-13-26(25)29)31(39)35-32(3,4)5/h6-12,17,19,21,27-28H,13-16,18,20H2,1-5H3,(H,33,38)(H,35,39)/t27-,28?/m0/s1
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n/an/a 95.6n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435285
PNG
(5-(3-(2H-1,2,3-triazol-2-yl)phenyl)-N- (tert-butyl...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)-n1nccn1
Show InChI InChI=1S/C33H36N6O2/c1-33(2,3)37-32(41)38-17-14-27-26(23-10-7-11-25(18-23)39-35-15-16-36-39)13-12-24(30(27)21-38)20-34-31(40)29-19-28(29)22-8-5-4-6-9-22/h4-13,15-16,18,28-29H,14,17,19-21H2,1-3H3,(H,34,40)(H,37,41)/t28-,29?/m0/s1
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n/an/a 97.6n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435317
PNG
(5-(3-(1H-pyrazol-1-yl)phenyl)-N-((S)-3- methyl-1,1...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(c2)-n2cccn2)c2CCN(Cc12)C(=O)N[C@@]1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C32H35N7O5S/c1-20-35-30(44-37-20)27-16-26(27)29(40)33-17-22-7-8-24(21-5-3-6-23(15-21)39-12-4-11-34-39)25-9-13-38(18-28(22)25)31(41)36-32(2)10-14-45(42,43)19-32/h3-8,11-12,15,26-27H,9-10,13-14,16-19H2,1-2H3,(H,33,40)(H,36,41)/t26?,27?,32-/m0/s1
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n/an/a 98n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435241
PNG
(8-(((trans)-2-(3-methyl-1,2,4- oxadiazol-5-yl) cyc...)
Show SMILES Cc1noc(n1)[C@H]1C[C@@H]1C(=O)NCc1ccc(-c2cccc(c2)-n2ccnn2)c2CCN(Cc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C31H29N9O3/c1-19-35-30(43-37-19)27-15-26(27)29(41)33-16-21-7-8-24(20-4-2-6-23(14-20)40-13-11-34-38-40)25-9-12-39(18-28(21)25)31(42)36-22-5-3-10-32-17-22/h2-8,10-11,13-14,17,26-27H,9,12,15-16,18H2,1H3,(H,33,41)(H,36,42)/t26-,27-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435237
PNG
(N-(isoxazol-3-yl)-8-(((trans)-2-(3- methyl-1,2,4-o...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)Nc1ccon1
Show InChI InChI=1S/C28H25F3N6O5/c1-15-33-26(42-35-15)22-12-21(22)25(38)32-13-17-5-6-19(16-3-2-4-18(11-16)41-28(29,30)31)20-7-9-37(14-23(17)20)27(39)34-24-8-10-40-36-24/h2-6,8,10-11,21-22H,7,9,12-14H2,1H3,(H,32,38)(H,34,36,39)/t21-,22-/m1/s1
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n/an/a 112n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435262
PNG
(N-(isoxazol-3-yl)-8-(((trans)-2-(3- methyl-1,2,4-o...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)Nc1ccon1
Show InChI InChI=1S/C28H25F3N6O4/c1-15-33-26(41-35-15)22-12-21(22)25(38)32-13-17-5-6-19(16-3-2-4-18(11-16)28(29,30)31)20-7-9-37(14-23(17)20)27(39)34-24-8-10-40-36-24/h2-6,8,10-11,21-22H,7,9,12-14H2,1H3,(H,32,38)(H,34,36,39)/t21-,22-/m1/s1
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n/an/a 126n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435261
PNG
(N-(isoxazol-3-yl)-5-(3- methoxyphenyl)-8-(((trans)...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2nc(C)no2)c2CN(CCc12)C(=O)Nc1ccon1
Show InChI InChI=1S/C28H28N6O5/c1-16-30-27(39-32-16)23-13-22(23)26(35)29-14-18-6-7-20(17-4-3-5-19(12-17)37-2)21-8-10-34(15-24(18)21)28(36)31-25-9-11-38-33-25/h3-7,9,11-12,22-23H,8,10,13-15H2,1-2H3,(H,29,35)(H,31,33,36)/t22-,23-/m1/s1
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n/an/a 144n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435279
PNG
(N-(tert-butyl)-5-(3-carbamoylphenyl)- 8-(((trans)-...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C32H36N4O3/c1-32(2,3)35-31(39)36-15-14-25-24(21-10-7-11-22(16-21)29(33)37)13-12-23(28(25)19-36)18-34-30(38)27-17-26(27)20-8-5-4-6-9-20/h4-13,16,26-27H,14-15,17-19H2,1-3H3,(H2,33,37)(H,34,38)(H,35,39)/t26-,27?/m0/s1
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n/an/a 155n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435245
PNG
(N-(tert-butyl)-5-(5-(2-hydroxypropan- 2-yl)pyridin...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cncc(c1)C(C)(C)O
Show InChI InChI=1S/C33H40N4O3/c1-32(2,3)36-31(39)37-14-13-26-25(23-15-24(19-34-17-23)33(4,5)40)12-11-22(29(26)20-37)18-35-30(38)28-16-27(28)21-9-7-6-8-10-21/h6-12,15,17,19,27-28,40H,13-14,16,18,20H2,1-5H3,(H,35,38)(H,36,39)/t27-,28?/m0/s1
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n/an/a 166n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435284
PNG
(N-(tert-butyl)-8-(((trans)-2- phenylcyclopropaneca...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cncc(c1)C(F)(F)F
Show InChI InChI=1S/C31H33F3N4O2/c1-30(2,3)37-29(40)38-12-11-24-23(21-13-22(17-35-15-21)31(32,33)34)10-9-20(27(24)18-38)16-36-28(39)26-14-25(26)19-7-5-4-6-8-19/h4-10,13,15,17,25-26H,11-12,14,16,18H2,1-3H3,(H,36,39)(H,37,40)/t25-,26?/m0/s1
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n/an/a 173n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435379
PNG
(US10568876, Example 138 | methyl 3-(2-benzoyl-8-((...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1ccccc1
Show InChI InChI=1S/C35H32N2O4/c1-41-35(40)26-14-8-13-25(19-26)28-16-15-27(21-36-33(38)31-20-30(31)23-9-4-2-5-10-23)32-22-37(18-17-29(28)32)34(39)24-11-6-3-7-12-24/h2-16,19,30-31H,17-18,20-22H2,1H3,(H,36,38)
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n/an/a 176n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435364
PNG
(US10568876, Example 125 | methyl 3-(2-(2-cycloprop...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)CC1CC1
Show InChI InChI=1S/C33H34N2O4/c1-39-33(38)24-9-5-8-23(17-24)26-13-12-25(19-34-32(37)29-18-28(29)22-6-3-2-4-7-22)30-20-35(15-14-27(26)30)31(36)16-21-10-11-21/h2-9,12-13,17,21,28-29H,10-11,14-16,18-20H2,1H3,(H,34,37)
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n/an/a 209n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435380
PNG
(US10568876, Example 139 | methyl 3-(2-(2-fluoroben...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1ccccc1F
Show InChI InChI=1S/C35H31FN2O4/c1-42-35(41)24-11-7-10-23(18-24)26-15-14-25(20-37-33(39)30-19-29(30)22-8-3-2-4-9-22)31-21-38(17-16-27(26)31)34(40)28-12-5-6-13-32(28)36/h2-15,18,29-30H,16-17,19-21H2,1H3,(H,37,39)
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n/an/a 219n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435296
PNG
(US10568876, Example 59 | ethyl 4-(5-(3-methoxyphen...)
Show SMILES CCOC(=O)CCCNC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1ccccc1)ccc2-c1cccc(OC)c1
Show InChI InChI=1S/C34H39N3O5/c1-3-42-32(38)13-8-17-35-34(40)37-18-16-28-27(24-11-7-12-26(19-24)41-2)15-14-25(31(28)22-37)21-36-33(39)30-20-29(30)23-9-5-4-6-10-23/h4-7,9-12,14-15,19,29-30H,3,8,13,16-18,20-22H2,1-2H3,(H,35,40)(H,36,39)/t29-,30+/m0/s1
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n/an/a 227n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435312
PNG
(5-(3-methoxyphenyl)-N-(2-methylbutyl)- 8-(((trans)...)
Show SMILES CCC(C)CNC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1ccccc1)ccc2-c1cccc(OC)c1
Show InChI InChI=1S/C33H39N3O3/c1-4-22(2)19-35-33(38)36-16-15-28-27(24-11-8-12-26(17-24)39-3)14-13-25(31(28)21-36)20-34-32(37)30-18-29(30)23-9-6-5-7-10-23/h5-14,17,22,29-30H,4,15-16,18-21H2,1-3H3,(H,34,37)(H,35,38)/t22?,29-,30+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435260
PNG
(5-(3-methoxyphenyl)-8-(((trans)-2- phenylcycloprop...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C33H32N4O3/c1-40-26-11-5-9-23(17-26)27-13-12-24(19-35-32(38)30-18-29(30)22-7-3-2-4-8-22)31-21-37(16-14-28(27)31)33(39)36-25-10-6-15-34-20-25/h2-13,15,17,20,29-30H,14,16,18-19,21H2,1H3,(H,35,38)(H,36,39)/t29-,30+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435297
PNG
(N-(1,1-dioxidotetrahydrothiophen-3-yl)- 8-((2-(3-m...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C29H30F3N5O6S/c1-16-34-27(43-36-16)24-12-23(24)26(38)33-13-18-5-6-21(17-3-2-4-20(11-17)42-29(30,31)32)22-7-9-37(14-25(18)22)28(39)35-19-8-10-44(40,41)15-19/h2-6,11,19,23-24H,7-10,12-15H2,1H3,(H,33,38)(H,35,39)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435332
PNG
(US10568876, Example 94 | methyl 3-(8-((2- phenylcy...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(Cc3ccccn3)CCc12
Show InChI InChI=1S/C34H33N3O3/c1-40-34(39)25-11-7-10-24(18-25)28-14-13-26(20-36-33(38)31-19-30(31)23-8-3-2-4-9-23)32-22-37(17-15-29(28)32)21-27-12-5-6-16-35-27/h2-14,16,18,30-31H,15,17,19-22H2,1H3,(H,36,38)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435376
PNG
(US10568876, Example 135 | methyl 3-(8-((2- phenylc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1ccccn1
Show InChI InChI=1S/C34H31N3O4/c1-41-34(40)24-11-7-10-23(18-24)26-14-13-25(20-36-32(38)29-19-28(29)22-8-3-2-4-9-22)30-21-37(17-15-27(26)30)33(39)31-12-5-6-16-35-31/h2-14,16,18,28-29H,15,17,19-21H2,1H3,(H,36,38)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435314
PNG
(N-(2-ethylhexyl)-5-(3-methoxyphenyl)-8- (((trans)-...)
Show SMILES CCCCC(CC)CNC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1ccccc1)ccc2-c1cccc(OC)c1
Show InChI InChI=1S/C36H45N3O3/c1-4-6-11-25(5-2)22-38-36(41)39-19-18-31-30(27-14-10-15-29(20-27)42-3)17-16-28(34(31)24-39)23-37-35(40)33-21-32(33)26-12-8-7-9-13-26/h7-10,12-17,20,25,32-33H,4-6,11,18-19,21-24H2,1-3H3,(H,37,40)(H,38,41)/t25?,32-,33+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435382
PNG
(US10568876, Example 141 | methyl 3-(2-(4-fluoroben...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C35H31FN2O4/c1-42-35(41)25-9-5-8-24(18-25)28-15-12-26(20-37-33(39)31-19-30(31)22-6-3-2-4-7-22)32-21-38(17-16-29(28)32)34(40)23-10-13-27(36)14-11-23/h2-15,18,30-31H,16-17,19-21H2,1H3,(H,37,39)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435371
PNG
(US10568876, Example 130 | methyl 3-(2-isobutyryl-8...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C(C)C
Show InChI InChI=1S/C32H34N2O4/c1-20(2)31(36)34-15-14-26-25(22-10-7-11-23(16-22)32(37)38-3)13-12-24(29(26)19-34)18-33-30(35)28-17-27(28)21-8-5-4-6-9-21/h4-13,16,20,27-28H,14-15,17-19H2,1-3H3,(H,33,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435259
PNG
(N-(isoxazol-3-yl)-5-(3- methoxyphenyl)-8-(((trans)...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)Nc1ccon1
Show InChI InChI=1S/C31H30N4O4/c1-38-23-9-5-8-21(16-23)24-11-10-22(18-32-30(36)27-17-26(27)20-6-3-2-4-7-20)28-19-35(14-12-25(24)28)31(37)33-29-13-15-39-34-29/h2-11,13,15-16,26-27H,12,14,17-19H2,1H3,(H,32,36)(H,33,34,37)/t26-,27+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435272
PNG
(5-(3-acetamidophenyl)-N-(tert-butyl)- 8-(((trans)-...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C33H38N4O3/c1-21(38)35-25-12-8-11-23(17-25)26-14-13-24(19-34-31(39)29-18-28(29)22-9-6-5-7-10-22)30-20-37(16-15-27(26)30)32(40)36-33(2,3)4/h5-14,17,28-29H,15-16,18-20H2,1-4H3,(H,34,39)(H,35,38)(H,36,40)/t28-,29?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435372
PNG
(US10568876, Example 131 | methyl 3-(2-(2- methylcy...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C1CC1C
Show InChI InChI=1S/C33H34N2O4/c1-20-15-27(20)32(37)35-14-13-26-25(22-9-6-10-23(16-22)33(38)39-2)12-11-24(30(26)19-35)18-34-31(36)29-17-28(29)21-7-4-3-5-8-21/h3-12,16,20,27-29H,13-15,17-19H2,1-2H3,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435341
PNG
((trans)-N-((2-((1-ethyl-1H-imidazol-2- yl)methyl)-...)
Show SMILES CCn1ccnc1CN1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1nc(C)no1)ccc2-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H31F3N6O3/c1-3-39-12-10-34-27(39)17-38-11-9-23-22(19-5-4-6-21(13-19)41-30(31,32)33)8-7-20(26(23)16-38)15-35-28(40)24-14-25(24)29-36-18(2)37-42-29/h4-8,10,12-13,24-25H,3,9,11,14-17H2,1-2H3,(H,35,40)/t24?,25-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435297
PNG
(N-(1,1-dioxidotetrahydrothiophen-3-yl)- 8-((2-(3-m...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C29H30F3N5O6S/c1-16-34-27(43-36-16)24-12-23(24)26(38)33-13-18-5-6-21(17-3-2-4-20(11-17)42-29(30,31)32)22-7-9-37(14-25(18)22)28(39)35-19-8-10-44(40,41)15-19/h2-6,11,19,23-24H,7-10,12-15H2,1H3,(H,33,38)(H,35,39)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435318
PNG
(N-((2-(2-(tert-butylamino)-2-oxoethyl)-5- (3-(trif...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(CC(=O)NC(C)(C)C)Cc12
Show InChI InChI=1S/C30H34F3N5O4/c1-17-35-28(42-37-17)24-13-23(24)27(40)34-14-19-8-9-21(18-6-5-7-20(12-18)41-30(31,32)33)22-10-11-38(15-25(19)22)16-26(39)36-29(2,3)4/h5-9,12,23-24H,10-11,13-16H2,1-4H3,(H,34,40)(H,36,39)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435298
PNG
(5-(3-methoxyphenyl)-8-(((trans)-2- phenylcycloprop...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)CC(C)(C)C
Show InChI InChI=1S/C36H45N3O3/c1-35(2,3)23-36(4,5)38-34(41)39-18-17-29-28(25-13-10-14-27(19-25)42-6)16-15-26(32(29)22-39)21-37-33(40)31-20-30(31)24-11-8-7-9-12-24/h7-16,19,30-31H,17-18,20-23H2,1-6H3,(H,37,40)(H,38,41)/t30-,31+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435251
PNG
(N-(tert-butyl)-5-(5-(2-hydroxypropan- 2-yl)pyridin...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cncc(c2)C(C)(C)O)c2CCN(Cc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C30H38N6O4/c1-17-33-27(40-35-17)24-12-23(24)26(37)32-14-18-7-8-21(19-11-20(15-31-13-19)30(5,6)39)22-9-10-36(16-25(18)22)28(38)34-29(2,3)4/h7-8,11,13,15,23-24,39H,9-10,12,14,16H2,1-6H3,(H,32,37)(H,34,38)/t23-,24-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435373
PNG
(US10568876, Example 132 | methyl 3-(2-(1- methylcy...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C1(C)CC1
Show InChI InChI=1S/C33H34N2O4/c1-33(14-15-33)32(38)35-16-13-26-25(22-9-6-10-23(17-22)31(37)39-2)12-11-24(29(26)20-35)19-34-30(36)28-18-27(28)21-7-4-3-5-8-21/h3-12,17,27-28H,13-16,18-20H2,1-2H3,(H,34,36)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435360
PNG
(US10568876, Example 121 | methyl 3-(2-(3-cycloprop...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1c[nH]nc1C1CC1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435319
PNG
(N-((2-(2-(diethylamino)-2-oxoethyl)-5-(3- (trifluo...)
Show SMILES CCN(CC)C(=O)CN1CCc2c(C1)c(CNC(=O)C1CC1c1nc(C)no1)ccc2-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C30H34F3N5O4/c1-4-38(5-2)27(39)17-37-12-11-23-22(19-7-6-8-21(13-19)41-30(31,32)33)10-9-20(26(23)16-37)15-34-28(40)24-14-25(24)29-35-18(3)36-42-29/h6-10,13,24-25H,4-5,11-12,14-17H2,1-3H3,(H,34,40)
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n/an/a 658n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435353
PNG
(N-((2-(3,3-dimethylbutanoyl)-5-(3- methoxyphenyl)-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)CC(C)(C)C
Show InChI InChI=1S/C33H38N2O3/c1-33(2,3)19-31(36)35-16-15-27-26(23-11-8-12-25(17-23)38-4)14-13-24(30(27)21-35)20-34-32(37)29-18-28(29)22-9-6-5-7-10-22/h5-14,17,28-29H,15-16,18-21H2,1-4H3,(H,34,37)
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n/an/a 714n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435320
PNG
(N-((2-(2-(cyclopropylamino)-2-oxoethyl)- 5-(3-(tri...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(CC(=O)NC3CC3)Cc12
Show InChI InChI=1S/C29H30F3N5O4/c1-16-34-28(41-36-16)24-12-23(24)27(39)33-13-18-5-8-21(17-3-2-4-20(11-17)40-29(30,31)32)22-9-10-37(14-25(18)22)15-26(38)35-19-6-7-19/h2-5,8,11,19,23-24H,6-7,9-10,12-15H2,1H3,(H,33,39)(H,35,38)
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n/an/a 722n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435354
PNG
(5-((trans)-2-(((2-(2-hydroxy-2- methylpropanoyl)-5...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H]2C[C@@H]2c2nc(C)no2)c2CN(CCc12)C(=O)C(C)(C)O
Show InChI InChI=1S/C28H32N4O5/c1-16-30-26(37-31-16)23-13-22(23)25(33)29-14-18-8-9-20(17-6-5-7-19(12-17)36-4)21-10-11-32(15-24(18)21)27(34)28(2,3)35/h5-9,12,22-23,35H,10-11,13-15H2,1-4H3,(H,29,33)/t22-,23-/m0/s1
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n/an/a 723n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435299
PNG
((trans)-N-((5-(3-methoxyphenyl)-2- (morpholine-4-c...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C32H35N3O4/c1-38-25-9-5-8-23(18-25)26-11-10-24(20-33-31(36)29-19-28(29)22-6-3-2-4-7-22)30-21-35(13-12-27(26)30)32(37)34-14-16-39-17-15-34/h2-11,18,28-29H,12-17,19-21H2,1H3,(H,33,36)/t28-,29+/m0/s1
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n/an/a 818n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435356
PNG
((trans)-N-((2-(2-hydroxy-2- methylpropanoyl)-5-(3-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)C(C)(C)O
Show InChI InChI=1S/C31H34N2O4/c1-31(2,36)30(35)33-15-14-25-24(21-10-7-11-23(16-21)37-3)13-12-22(28(25)19-33)18-32-29(34)27-17-26(27)20-8-5-4-6-9-20/h4-13,16,26-27,36H,14-15,17-19H2,1-3H3,(H,32,34)/t26-,27+/m0/s1
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n/an/a 831n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435276
PNG
(N-(tert-butyl)-5-(3- (methylsulfonamido)phenyl)-8-...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(NS(C)(=O)=O)c1
Show InChI InChI=1S/C32H38N4O4S/c1-32(2,3)34-31(38)36-16-15-26-25(22-11-8-12-24(17-22)35-41(4,39)40)14-13-23(29(26)20-36)19-33-30(37)28-18-27(28)21-9-6-5-7-10-21/h5-14,17,27-28,35H,15-16,18-20H2,1-4H3,(H,33,37)(H,34,38)/t27-,28?/m0/s1
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n/an/a 832n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435352
PNG
((trans)-N-((5-(3-methoxyphenyl)-2- pivaloyl-1,2,3,...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C(C)(C)C
Show InChI InChI=1S/C32H36N2O3/c1-32(2,3)31(36)34-16-15-26-25(22-11-8-12-24(17-22)37-4)14-13-23(29(26)20-34)19-33-30(35)28-18-27(28)21-9-6-5-7-10-21/h5-14,17,27-28H,15-16,18-20H2,1-4H3,(H,33,35)
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n/an/a 887n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435297
PNG
(N-(1,1-dioxidotetrahydrothiophen-3-yl)- 8-((2-(3-m...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C29H30F3N5O6S/c1-16-34-27(43-36-16)24-12-23(24)26(38)33-13-18-5-6-21(17-3-2-4-20(11-17)42-29(30,31)32)22-7-9-37(14-25(18)22)28(39)35-19-8-10-44(40,41)15-19/h2-6,11,19,23-24H,7-10,12-15H2,1H3,(H,33,38)(H,35,39)
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n/an/a 892n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435350
PNG
(US10568876, Example 111)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C34H30F2N2O3/c1-41-27-9-5-8-22(16-27)28-11-10-23(19-37-33(39)31-18-30(31)21-6-3-2-4-7-21)32-20-38(13-12-29(28)32)34(40)24-14-25(35)17-26(36)15-24/h2-11,14-17,30-31H,12-13,18-20H2,1H3,(H,37,39)
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n/an/a 971n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435264
PNG
(N-(tert-butyl)-5-(5- (hydroxymethyl)pyridin-3-yl)-...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cncc(CO)c1
Show InChI InChI=1S/C31H36N4O3/c1-31(2,3)34-30(38)35-12-11-25-24(23-13-20(19-36)15-32-16-23)10-9-22(28(25)18-35)17-33-29(37)27-14-26(27)21-7-5-4-6-8-21/h4-10,13,15-16,26-27,36H,11-12,14,17-19H2,1-3H3,(H,33,37)(H,34,38)/t26-,27?/m0/s1
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n/an/a 992n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435330
PNG
((trans)-N-((2-(3,5-difluorobenzyl)-5-(3 methoxyphe...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H]2C[C@@H]2c2ccccc2)c2CN(Cc3cc(F)cc(F)c3)CCc12
Show InChI InChI=1S/C34H32F2N2O2/c1-40-28-9-5-8-24(16-28)29-11-10-25(19-37-34(39)32-18-31(32)23-6-3-2-4-7-23)33-21-38(13-12-30(29)33)20-22-14-26(35)17-27(36)15-22/h2-11,14-17,31-32H,12-13,18-21H2,1H3,(H,37,39)/t31-,32+/m1/s1
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n/an/a 1.15E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435271
PNG
(N-(tert-butyl)-5-(1-phenyl-1H-pyrazol- 4-yl)-8-(((...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C34H37N5O2/c1-34(2,3)37-33(41)38-17-16-28-27(25-20-36-39(21-25)26-12-8-5-9-13-26)15-14-24(31(28)22-38)19-35-32(40)30-18-29(30)23-10-6-4-7-11-23/h4-15,20-21,29-30H,16-19,22H2,1-3H3,(H,35,40)(H,37,41)/t29-,30?/m0/s1
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n/an/a 1.17E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435266
PNG
(N-(tert-butyl)-5-(1-methyl-1H- pyrazol-5-yl)-8-(((...)
Show SMILES Cn1nccc1-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H35N5O2/c1-29(2,3)32-28(36)34-15-13-21-22(26-12-14-31-33(26)4)11-10-20(25(21)18-34)17-30-27(35)24-16-23(24)19-8-6-5-7-9-19/h5-12,14,23-24H,13,15-18H2,1-4H3,(H,30,35)(H,32,36)/t23-,24?/m0/s1
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n/an/a 1.17E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435331
PNG
(N-((5-(3-methoxyphenyl)-2-(2,2,2- trifluoroethyl)-...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CC(F)(F)F)CCc12
Show InChI InChI=1S/C29H29F3N2O2/c1-36-22-9-5-8-20(14-22)23-11-10-21(27-17-34(13-12-24(23)27)18-29(30,31)32)16-33-28(35)26-15-25(26)19-6-3-2-4-7-19/h2-11,14,25-26H,12-13,15-18H2,1H3,(H,33,35)
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n/an/a 1.22E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435367
PNG
(US10568876, Example 127 | methyl 3-(8-((2- phenylc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)CCC(F)(F)F
Show InChI InChI=1S/C32H31F3N2O4/c1-41-31(40)22-9-5-8-21(16-22)24-11-10-23(18-36-30(39)27-17-26(27)20-6-3-2-4-7-20)28-19-37(15-13-25(24)28)29(38)12-14-32(33,34)35/h2-11,16,26-27H,12-15,17-19H2,1H3,(H,36,39)
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n/an/a 1.23E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435321
PNG
(N-((2-(2-amino-2-oxoethyl)-5-(3- (trifluoromethoxy...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(CC(N)=O)Cc12
Show InChI InChI=1S/C26H26F3N5O4/c1-14-32-25(38-33-14)21-10-20(21)24(36)31-11-16-5-6-18(15-3-2-4-17(9-15)37-26(27,28)29)19-7-8-34(12-22(16)19)13-23(30)35/h2-6,9,20-21H,7-8,10-13H2,1H3,(H2,30,35)(H,31,36)
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n/an/a 1.24E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435357
PNG
((trans)-N-((5-(3-methoxyphenyl)-2- (3,3,3-trifluor...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)C(CO)C(F)(F)F
Show InChI InChI=1S/C31H31F3N2O4/c1-40-22-9-5-8-20(14-22)23-11-10-21(16-35-29(38)26-15-25(26)19-6-3-2-4-7-19)27-17-36(13-12-24(23)27)30(39)28(18-37)31(32,33)34/h2-11,14,25-26,28,37H,12-13,15-18H2,1H3,(H,35,38)/t25-,26+,28?/m0/s1
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n/an/a 1.31E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435362
PNG
(US10568876, Example 123 | methyl 3-(8-((2- phenylc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C1(CC1)C(F)(F)F
Show InChI InChI=1S/C33H31F3N2O4/c1-42-30(40)22-9-5-8-21(16-22)24-11-10-23(18-37-29(39)27-17-26(27)20-6-3-2-4-7-20)28-19-38(15-12-25(24)28)31(41)32(13-14-32)33(34,35)36/h2-11,16,26-27H,12-15,17-19H2,1H3,(H,37,39)
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n/an/a 1.33E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435322
PNG
((trans)-2-(((2-(tert-butylcarbamoyl)-5-(3- methoxy...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@H]2C[C@@H]2C(O)=O)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C27H33N3O5/c1-27(2,3)29-26(34)30-11-10-20-19(16-6-5-7-18(12-16)35-4)9-8-17(23(20)15-30)14-28-24(31)21-13-22(21)25(32)33/h5-9,12,21-22H,10-11,13-15H2,1-4H3,(H,28,31)(H,29,34)(H,32,33)/t21-,22-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435275
PNG
(N-(tert-butyl)-5-(3- (cyclopropylcarbamoyl)phenyl)...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)C(=O)NC1CC1
Show InChI InChI=1S/C35H40N4O3/c1-35(2,3)38-34(42)39-17-16-28-27(23-10-7-11-24(18-23)32(40)37-26-13-14-26)15-12-25(31(28)21-39)20-36-33(41)30-19-29(30)22-8-5-4-6-9-22/h4-12,15,18,26,29-30H,13-14,16-17,19-21H2,1-3H3,(H,36,41)(H,37,40)(H,38,42)/t29-,30?/m0/s1
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n/an/a 1.43E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435278
PNG
(N-(tert-butyl)-5-(3,5-dimethylisoxazol- 4-yl)-8-((...)
Show SMILES Cc1noc(C)c1-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C30H36N4O3/c1-18-27(19(2)37-33-18)23-12-11-21(16-31-28(35)25-15-24(25)20-9-7-6-8-10-20)26-17-34(14-13-22(23)26)29(36)32-30(3,4)5/h6-12,24-25H,13-17H2,1-5H3,(H,31,35)(H,32,36)/t24-,25?/m0/s1
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n/an/a 1.44E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435268
PNG
(N-(tert-butyl)-8-(((trans)-2- phenylcyclopropaneca...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1ccnc2[nH]ccc12
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n/an/a 1.46E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435381
PNG
(US10568876, Example 140 | methyl 3-(2-(3-fluoroben...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1cccc(F)c1
Show InChI InChI=1S/C35H31FN2O4/c1-42-35(41)25-11-5-9-23(17-25)28-14-13-26(20-37-33(39)31-19-30(31)22-7-3-2-4-8-22)32-21-38(16-15-29(28)32)34(40)24-10-6-12-27(36)18-24/h2-14,17-18,30-31H,15-16,19-21H2,1H3,(H,37,39)
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n/an/a 1.53E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435323
PNG
(N-((2-(2-((2,4-dimethoxybenzyl)amino)-2- oxoethyl)...)
Show SMILES COc1ccc(CNC(=O)CN2CCc3c(C2)c(CNC(=O)C2CC2c2nc(C)no2)ccc3-c2cccc(OC(F)(F)F)c2)c(OC)c1
Show InChI InChI=1S/C35H36F3N5O6/c1-20-41-34(49-42-20)29-15-28(29)33(45)40-16-22-8-10-26(21-5-4-6-25(13-21)48-35(36,37)38)27-11-12-43(18-30(22)27)19-32(44)39-17-23-7-9-24(46-2)14-31(23)47-3/h4-10,13-14,28-29H,11-12,15-19H2,1-3H3,(H,39,44)(H,40,45)
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n/an/a 1.54E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435358
PNG
((trans)-N-((5-(3-methoxyphenyl)-2- (3,3,3-trifluor...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)C(O)C(F)(F)F
Show InChI InChI=1S/C30H29F3N2O4/c1-39-21-9-5-8-19(14-21)22-11-10-20(16-34-28(37)25-15-24(25)18-6-3-2-4-7-18)26-17-35(13-12-23(22)26)29(38)27(36)30(31,32)33/h2-11,14,24-25,27,36H,12-13,15-17H2,1H3,(H,34,37)/t24-,25+,27?/m0/s1
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n/an/a 1.54E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435355
PNG
((trans)-N-((2-(2-hydroxy-2- methylpropanoyl)-5-(3-...)
Show SMILES Cc1noc(n1)[C@H]1C[C@@H]1C(=O)NCc1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)C(C)(C)O
Show InChI InChI=1S/C28H29F3N4O4/c1-15-33-25(39-34-15)22-12-21(22)24(36)32-13-17-7-8-19(16-5-4-6-18(11-16)28(29,30)31)20-9-10-35(14-23(17)20)26(37)27(2,3)38/h4-8,11,21-22,38H,9-10,12-14H2,1-3H3,(H,32,36)/t21-,22-/m0/s1
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n/an/a 1.58E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435359
PNG
((trans)-N-((2-(2-hydroxy-2- methylpropanoyl)-5-(3-...)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)C(C)(C)O
Show InChI InChI=1S/C28H29F3N4O4/c1-15-33-25(39-34-15)22-12-21(22)24(36)32-13-17-7-8-19(16-5-4-6-18(11-16)28(29,30)31)20-9-10-35(14-23(17)20)26(37)27(2,3)38/h4-8,11,21-22,38H,9-10,12-14H2,1-3H3,(H,32,36)/t21-,22-/m1/s1
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n/an/a 1.58E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435368
PNG
(US10568876, Example 128 | methyl 3-(2-(1- cyanocyc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C1(CC1)C#N
Show InChI InChI=1S/C33H31N3O4/c1-40-31(38)23-9-5-8-22(16-23)25-11-10-24(18-35-30(37)28-17-27(28)21-6-3-2-4-7-21)29-19-36(15-12-26(25)29)32(39)33(20-34)13-14-33/h2-11,16,27-28H,12-15,17-19H2,1H3,(H,35,37)
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n/an/a 1.59E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435256
PNG
(5-(3-methoxyphenyl)-N-(3- methylisoxazol-5-yl)-8-(...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)Nc1cc(C)no1
Show InChI InChI=1S/C32H32N4O4/c1-20-15-30(40-35-20)34-32(38)36-14-13-26-25(22-9-6-10-24(16-22)39-2)12-11-23(29(26)19-36)18-33-31(37)28-17-27(28)21-7-4-3-5-8-21/h3-12,15-16,27-28H,13-14,17-19H2,1-2H3,(H,33,37)(H,34,38)/t27-,28+/m0/s1
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n/an/a 1.64E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435342
PNG
((trans)-N-((2-(2-(4,4-dimethyloxazolidin- 3-yl)-2-...)
Show SMILES Cc1noc(n1)[C@@H]1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(CC(=O)N3COCC3(C)C)Cc12
Show InChI InChI=1S/C31H34F3N5O5/c1-18-36-29(44-37-18)25-12-24(25)28(41)35-13-20-7-8-22(19-5-4-6-21(11-19)43-31(32,33)34)23-9-10-38(14-26(20)23)15-27(40)39-17-42-16-30(39,2)3/h4-8,11,24-25H,9-10,12-17H2,1-3H3,(H,35,41)/t24?,25-/m1/s1
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n/an/a 1.76E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435366
PNG
(US10568876, Example 126 | methyl 3-(2-(3-methoxypr...)
Show SMILES COCCC(=O)N1CCc2c(C1)c(CNC(=O)C1CC1c1ccccc1)ccc2-c1cccc(c1)C(=O)OC
Show InChI InChI=1S/C32H34N2O5/c1-38-16-14-30(35)34-15-13-26-25(22-9-6-10-23(17-22)32(37)39-2)12-11-24(29(26)20-34)19-33-31(36)28-18-27(28)21-7-4-3-5-8-21/h3-12,17,27-28H,13-16,18-20H2,1-2H3,(H,33,36)
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n/an/a 1.77E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435370
PNG
(US10568876, Example 129 | methyl 3-(8-((2- phenylc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)CC(F)(F)F
Show InChI InChI=1S/C31H29F3N2O4/c1-40-30(39)21-9-5-8-20(14-21)23-11-10-22(17-35-29(38)26-15-25(26)19-6-3-2-4-7-19)27-18-36(13-12-24(23)27)28(37)16-31(32,33)34/h2-11,14,25-26H,12-13,15-18H2,1H3,(H,35,38)
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n/an/a 1.82E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435345
PNG
((trans)-2-(3-methyl-1,2,4-oxadiazol-5-yl)- N-((2-(...)
Show SMILES Cc1noc(n1)[C@@H]1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc3scnc3C)Cc12
Show InChI InChI=1S/C29H28F3N5O3S/c1-16-26(41-15-34-16)14-37-9-8-22-21(18-4-3-5-20(10-18)39-29(30,31)32)7-6-19(25(22)13-37)12-33-27(38)23-11-24(23)28-35-17(2)36-40-28/h3-7,10,15,23-24H,8-9,11-14H2,1-2H3,(H,33,38)/t23?,24-/m1/s1
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n/an/a 1.84E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435253
PNG
(5-(3-methoxyphenyl)-8-(((trans)-2- phenylcycloprop...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)Nc1ccncc1
Show InChI InChI=1S/C33H32N4O3/c1-40-26-9-5-8-23(18-26)27-11-10-24(20-35-32(38)30-19-29(30)22-6-3-2-4-7-22)31-21-37(17-14-28(27)31)33(39)36-25-12-15-34-16-13-25/h2-13,15-16,18,29-30H,14,17,19-21H2,1H3,(H,35,38)(H,34,36,39)/t29-,30+/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435377
PNG
(US10568876, Example 136 | methyl 3-(2-(2-ethoxyace...)
Show SMILES CCOCC(=O)N1CCc2c(C1)c(CNC(=O)C1CC1c1ccccc1)ccc2-c1cccc(c1)C(=O)OC
Show InChI InChI=1S/C32H34N2O5/c1-3-39-20-30(35)34-15-14-26-25(22-10-7-11-23(16-22)32(37)38-2)13-12-24(29(26)19-34)18-33-31(36)28-17-27(28)21-8-5-4-6-9-21/h4-13,16,27-28H,3,14-15,17-20H2,1-2H3,(H,33,36)
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n/an/a 2.17E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435324
PNG
(N-((2-(2-(((trans)-2- (methoxymethyl)cyclopentyl)a...)
Show SMILES COC[C@H]1CCC[C@H]1NC(=O)CN1CCc2c(C1)c(CNC(=O)C1CC1c1nc(C)no1)ccc2-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C33H38F3N5O5/c1-19-38-32(46-40-19)27-14-26(27)31(43)37-15-21-9-10-24(20-5-3-7-23(13-20)45-33(34,35)36)25-11-12-41(16-28(21)25)17-30(42)39-29-8-4-6-22(29)18-44-2/h3,5,7,9-10,13,22,26-27,29H,4,6,8,11-12,14-18H2,1-2H3,(H,37,43)(H,39,42)/t22-,26?,27?,29-/m1/s1
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n/an/a 2.29E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435335
PNG
(US10568876, Example 97 | methyl 3-(8-((2- phenylcy...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(Cc3ccncc3)CCc12
Show InChI InChI=1S/C34H33N3O3/c1-40-34(39)26-9-5-8-25(18-26)28-11-10-27(20-36-33(38)31-19-30(31)24-6-3-2-4-7-24)32-22-37(17-14-29(28)32)21-23-12-15-35-16-13-23/h2-13,15-16,18,30-31H,14,17,19-22H2,1H3,(H,36,38)
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n/an/a 2.41E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435374
PNG
(US10568876, Example 133 | methyl 3-(2-isonicotinoy...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1ccncc1
Show InChI InChI=1S/C34H31N3O4/c1-41-34(40)25-9-5-8-24(18-25)27-11-10-26(20-36-32(38)30-19-29(30)22-6-3-2-4-7-22)31-21-37(17-14-28(27)31)33(39)23-12-15-35-16-13-23/h2-13,15-16,18,29-30H,14,17,19-21H2,1H3,(H,36,38)
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n/an/a 2.51E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435344
PNG
((trans)-2-(3-methyl-1,2,4-oxadiazol-5-yl)- N-((2-(...)
Show SMILES Cc1noc(n1)[C@@H]1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc3ccncn3)Cc12
Show InChI InChI=1S/C29H27F3N6O3/c1-17-36-28(41-37-17)25-12-24(25)27(39)34-13-19-5-6-22(18-3-2-4-21(11-18)40-29(30,31)32)23-8-10-38(15-26(19)23)14-20-7-9-33-16-35-20/h2-7,9,11,16,24-25H,8,10,12-15H2,1H3,(H,34,39)/t24?,25-/m1/s1
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n/an/a 2.61E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435282
PNG
(N-(tert-butyl)-5-(1-oxoisoindolin-5- yl)-8-(((tran...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C33H36N4O3/c1-33(2,3)36-32(40)37-14-13-26-24(21-9-12-25-23(15-21)18-35-30(25)38)11-10-22(29(26)19-37)17-34-31(39)28-16-27(28)20-7-5-4-6-8-20/h4-12,15,27-28H,13-14,16-19H2,1-3H3,(H,34,39)(H,35,38)(H,36,40)/t27-,28?/m0/s1
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n/an/a 2.65E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435336
PNG
(US10568876, Example 98 | methyl 3-(2-(4-fluorobenz...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(Cc3ccc(F)cc3)CCc12
Show InChI InChI=1S/C35H33FN2O3/c1-41-35(40)26-9-5-8-25(18-26)29-15-12-27(20-37-34(39)32-19-31(32)24-6-3-2-4-7-24)33-22-38(17-16-30(29)33)21-23-10-13-28(36)14-11-23/h2-15,18,31-32H,16-17,19-22H2,1H3,(H,37,39)
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n/an/a 2.68E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435327
PNG
(US10568876, Example 89)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)S(C)(=O)=O
Show InChI InChI=1S/C28H30N2O4S/c1-34-22-10-6-9-20(15-22)23-12-11-21(27-18-30(35(2,32)33)14-13-24(23)27)17-29-28(31)26-16-25(26)19-7-4-3-5-8-19/h3-12,15,25-26H,13-14,16-18H2,1-2H3,(H,29,31)
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n/an/a 2.78E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435334
PNG
(US10568876, Example 96 | methyl 3-(2-((1-cycloprop...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(Cc3cc(C)n(C4CC4)c3C)CCc12
Show InChI InChI=1S/C38H41N3O3/c1-24-18-30(25(2)41(24)31-13-14-31)22-40-17-16-33-32(27-10-7-11-28(19-27)38(43)44-3)15-12-29(36(33)23-40)21-39-37(42)35-20-34(35)26-8-5-4-6-9-26/h4-12,15,18-19,31,34-35H,13-14,16-17,20-23H2,1-3H3,(H,39,42)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435269
PNG
(N-(tert-butyl)-5-(1-methyl-1H- benzo[d][1,2,3]tria...)
Show SMILES Cn1nnc2ccc(cc12)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C32H36N6O2/c1-32(2,3)34-31(40)38-15-14-24-23(21-11-13-28-29(16-21)37(4)36-35-28)12-10-22(27(24)19-38)18-33-30(39)26-17-25(26)20-8-6-5-7-9-20/h5-13,16,25-26H,14-15,17-19H2,1-4H3,(H,33,39)(H,34,40)/t25-,26?/m0/s1
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n/an/a 2.86E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435351
PNG
(US10568876, Example 112 | methyl 3-(2-(2-phenylace...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)Cc1ccccc1
Show InChI InChI=1S/C36H34N2O4/c1-42-36(41)27-14-8-13-26(20-27)29-16-15-28(22-37-35(40)32-21-31(32)25-11-6-3-7-12-25)33-23-38(18-17-30(29)33)34(39)19-24-9-4-2-5-10-24/h2-16,20,31-32H,17-19,21-23H2,1H3,(H,37,40)
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n/an/a 2.93E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435300
PNG
(US10568876, Example 63 | methyl 1-(5-(3-methoxyphe...)
Show SMILES COC(=O)C1CCN(CC1)C(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1ccccc1)ccc2-c1cccc(OC)c1
Show InChI InChI=1S/C35H39N3O5/c1-42-27-10-6-9-25(19-27)28-12-11-26(21-36-33(39)31-20-30(31)23-7-4-3-5-8-23)32-22-38(18-15-29(28)32)35(41)37-16-13-24(14-17-37)34(40)43-2/h3-12,19,24,30-31H,13-18,20-22H2,1-2H3,(H,36,39)/t30-,31+/m0/s1
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n/an/a 3.09E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435250
PNG
(5-(3-methoxyphenyl)-8-(((trans)-2- phenylcycloprop...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)Nc1ccccn1
Show InChI InChI=1S/C33H32N4O3/c1-40-25-11-7-10-23(18-25)26-14-13-24(20-35-32(38)29-19-28(29)22-8-3-2-4-9-22)30-21-37(17-15-27(26)30)33(39)36-31-12-5-6-16-34-31/h2-14,16,18,28-29H,15,17,19-21H2,1H3,(H,35,38)(H,34,36,39)/t28-,29+/m0/s1
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n/an/a 3.11E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435280
PNG
(5-([1,2,4]triazolo[1,5-a]pyridin-7-yl)- N-(tert-bu...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1ccn2ncnc2c1
Show InChI InChI=1S/C31H34N6O2/c1-31(2,3)35-30(39)36-13-12-24-23(21-11-14-37-28(15-21)33-19-34-37)10-9-22(27(24)18-36)17-32-29(38)26-16-25(26)20-7-5-4-6-8-20/h4-11,14-15,19,25-26H,12-13,16-18H2,1-3H3,(H,32,38)(H,35,39)/t25-,26?/m0/s1
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n/an/a 3.13E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435349
PNG
(N-((5-(3-methoxyphenyl)-2-(pyrimidin-2- yl)-1,2,3,...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)c1ncccn1
Show InChI InChI=1S/C31H30N4O2/c1-37-24-10-5-9-22(17-24)25-12-11-23(19-34-30(36)28-18-27(28)21-7-3-2-4-8-21)29-20-35(16-13-26(25)29)31-32-14-6-15-33-31/h2-12,14-15,17,27-28H,13,16,18-20H2,1H3,(H,34,36)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435378
PNG
(US10568876, Example 137 | methyl 3-(2-(4- methylcy...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C1CCC(C)CC1
Show InChI InChI=1S/C36H40N2O4/c1-23-11-13-25(14-12-23)35(40)38-18-17-30-29(26-9-6-10-27(19-26)36(41)42-2)16-15-28(33(30)22-38)21-37-34(39)32-20-31(32)24-7-4-3-5-8-24/h3-10,15-16,19,23,25,31-32H,11-14,17-18,20-22H2,1-2H3,(H,37,39)
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n/an/a 3.34E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435338
PNG
(US10568876, Example 100 | methyl 3-(8-((2- phenylc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCC(F)(F)F)CCc12
Show InChI InChI=1S/C31H31F3N2O3/c1-39-30(38)22-9-5-8-21(16-22)24-11-10-23(28-19-36(14-12-25(24)28)15-13-31(32,33)34)18-35-29(37)27-17-26(27)20-6-3-2-4-7-20/h2-11,16,26-27H,12-15,17-19H2,1H3,(H,35,37)
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n/an/a 3.47E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435375
PNG
(US10568876, Example 134 | methyl 3-(2-nicotinoyl-8...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1cccnc1
Show InChI InChI=1S/C34H31N3O4/c1-41-34(40)24-10-5-9-23(17-24)27-13-12-25(20-36-32(38)30-18-29(30)22-7-3-2-4-8-22)31-21-37(16-14-28(27)31)33(39)26-11-6-15-35-19-26/h2-13,15,17,19,29-30H,14,16,18,20-21H2,1H3,(H,36,38)
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n/an/a 3.56E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435333
PNG
(US10568876, Example 95 | methyl 3-(2-((1,5-dimethy...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(Cc3ncn(C)c3C)CCc12
Show InChI InChI=1S/C34H36N4O3/c1-22-32(36-21-37(22)2)20-38-15-14-28-27(24-10-7-11-25(16-24)34(40)41-3)13-12-26(31(28)19-38)18-35-33(39)30-17-29(30)23-8-5-4-6-9-23/h4-13,16,21,29-30H,14-15,17-20H2,1-3H3,(H,35,39)
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n/an/a 3.78E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435337
PNG
(US10568876, Example 99 | methyl 3-(8-((2- phenylcy...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(Cc3cccnc3)CCc12
Show InChI InChI=1S/C34H33N3O3/c1-40-34(39)26-11-5-10-25(17-26)28-13-12-27(20-36-33(38)31-18-30(31)24-8-3-2-4-9-24)32-22-37(16-14-29(28)32)21-23-7-6-15-35-19-23/h2-13,15,17,19,30-31H,14,16,18,20-22H2,1H3,(H,36,38)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435348
PNG
(US10568876, Example 109)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2C[C@@H]2c2ccccc2)c2CN(CCc12)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C32H29F3N4O2/c1-41-23-9-5-8-21(16-23)24-11-10-22(18-37-30(40)27-17-26(27)20-6-3-2-4-7-20)28-19-39(15-13-25(24)28)31-36-14-12-29(38-31)32(33,34)35/h2-12,14,16,26-27H,13,15,17-19H2,1H3,(H,37,40)/t26-,27?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435325
PNG
(N-((2-(2-(cyclobutylamino)-2-oxoethyl)-5- (3-(trif...)
Show SMILES Cc1noc(n1)C1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(CC(=O)NC3CCC3)Cc12
Show InChI InChI=1S/C30H32F3N5O4/c1-17-35-29(42-37-17)25-13-24(25)28(40)34-14-19-8-9-22(18-4-2-7-21(12-18)41-30(31,32)33)23-10-11-38(15-26(19)23)16-27(39)36-20-5-3-6-20/h2,4,7-9,12,20,24-25H,3,5-6,10-11,13-16H2,1H3,(H,34,40)(H,36,39)
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n/an/a 4.22E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435301
PNG
(4-(5-(3-methoxyphenyl)-8-(((trans)-2- phenylcyclop...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NCCCC(O)=O
Show InChI InChI=1S/C32H35N3O5/c1-40-24-10-5-9-22(17-24)25-13-12-23(19-34-31(38)28-18-27(28)21-7-3-2-4-8-21)29-20-35(16-14-26(25)29)32(39)33-15-6-11-30(36)37/h2-5,7-10,12-13,17,27-28H,6,11,14-16,18-20H2,1H3,(H,33,39)(H,34,38)(H,36,37)/t27-,28+/m0/s1
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n/an/a 4.28E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435329
PNG
((trans)-N-((2-(2-(3,3- dimethylmorpholino)-2-oxoet...)
Show SMILES Cc1noc(n1)[C@@H]1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(CC(=O)N3CCOCC3(C)C)Cc12
Show InChI InChI=1S/C32H36F3N5O5/c1-19-37-30(45-38-19)26-14-25(26)29(42)36-15-21-7-8-23(20-5-4-6-22(13-20)44-32(33,34)35)24-9-10-39(16-27(21)24)17-28(41)40-11-12-43-18-31(40,2)3/h4-8,13,25-26H,9-12,14-18H2,1-3H3,(H,36,42)/t25?,26-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435340
PNG
((trans)-N-((2-((5-cyclopropyl-1,2,4- oxadiazol-3-y...)
Show SMILES Cc1noc(n1)[C@@H]1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc3noc(n3)C3CC3)Cc12
Show InChI InChI=1S/C30H29F3N6O4/c1-16-35-29(43-37-16)24-12-23(24)27(40)34-13-19-7-8-21(18-3-2-4-20(11-18)41-30(31,32)33)22-9-10-39(14-25(19)22)15-26-36-28(42-38-26)17-5-6-17/h2-4,7-8,11,17,23-24H,5-6,9-10,12-15H2,1H3,(H,34,40)/t23?,24-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435265
PNG
(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)- N-(tert-bu...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1ccc2ncnn2c1
Show InChI InChI=1S/C31H34N6O2/c1-31(2,3)35-30(39)36-14-13-24-23(22-10-12-28-33-19-34-37(28)17-22)11-9-21(27(24)18-36)16-32-29(38)26-15-25(26)20-7-5-4-6-8-20/h4-12,17,19,25-26H,13-16,18H2,1-3H3,(H,32,38)(H,35,39)/t25-,26?/m0/s1
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n/an/a 4.64E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435346
PNG
((trans)-2-(3-methyl-1,2,4-oxadiazol-5-yl)- N-((2-(...)
Show SMILES Cc1noc(n1)[C@@H]1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc3cnccn3)Cc12
Show InChI InChI=1S/C29H27F3N6O3/c1-17-36-28(41-37-17)25-12-24(25)27(39)35-13-19-5-6-22(18-3-2-4-21(11-18)40-29(30,31)32)23-7-10-38(16-26(19)23)15-20-14-33-8-9-34-20/h2-6,8-9,11,14,24-25H,7,10,12-13,15-16H2,1H3,(H,35,39)/t24?,25-/m1/s1
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n/an/a 4.77E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435277
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-N-(tert- butyl)-8-(((...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C35H39N5O2/c1-35(2,3)38-34(42)39-17-16-29-28(27-20-37-40(22-27)21-24-10-6-4-7-11-24)15-14-26(32(29)23-39)19-36-33(41)31-18-30(31)25-12-8-5-9-13-25/h4-15,20,22,30-31H,16-19,21,23H2,1-3H3,(H,36,41)(H,38,42)/t30-,31?/m0/s1
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n/an/a 4.79E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435328
PNG
(US10568876, Example 90)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(Cc3ccccc3)CCc12
Show InChI InChI=1S/C34H34N2O2/c1-38-28-14-8-13-26(19-28)29-16-15-27(21-35-34(37)32-20-31(32)25-11-6-3-7-12-25)33-23-36(18-17-30(29)33)22-24-9-4-2-5-10-24/h2-16,19,31-32H,17-18,20-23H2,1H3,(H,35,37)
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n/an/a 4.85E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435343
PNG
((trans)-N-((2-((5-isopropyl-1,2,4- oxadiazol-3-yl)...)
Show SMILES CC(C)c1nc(CN2CCc3c(C2)c(CNC(=O)C2C[C@H]2c2nc(C)no2)ccc3-c2cccc(OC(F)(F)F)c2)no1
Show InChI InChI=1S/C30H31F3N6O4/c1-16(2)28-36-26(38-42-28)15-39-10-9-22-21(18-5-4-6-20(11-18)41-30(31,32)33)8-7-19(25(22)14-39)13-34-27(40)23-12-24(23)29-35-17(3)37-43-29/h4-8,11,16,23-24H,9-10,12-15H2,1-3H3,(H,34,40)/t23?,24-/m1/s1
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n/an/a 5.09E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435363
PNG
(US10568876, Example 124 | methyl 3-(2-(3-(1H-pyrro...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1cccc(c1)-n1cccc1
Show InChI InChI=1S/C39H35N3O4/c1-46-39(45)29-13-7-11-27(21-29)32-16-15-30(24-40-37(43)35-23-34(35)26-9-3-2-4-10-26)36-25-42(20-17-33(32)36)38(44)28-12-8-14-31(22-28)41-18-5-6-19-41/h2-16,18-19,21-22,34-35H,17,20,23-25H2,1H3,(H,40,43)
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n/an/a 5.49E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435361
PNG
(US10568876, Example 122 | methyl 3-(2-(5-isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)c1cnoc1C(C)C
Show InChI InChI=1S/C35H35N3O5/c1-21(2)32-30(19-37-43-32)34(40)38-15-14-27-26(23-10-7-11-24(16-23)35(41)42-3)13-12-25(31(27)20-38)18-36-33(39)29-17-28(29)22-8-5-4-6-9-22/h4-13,16,19,21,28-29H,14-15,17-18,20H2,1-3H3,(H,36,39)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435267
PNG
(N-(tert-butyl)-5-(3-(3,5-dimethyl-1H- pyrazol-1-yl...)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)-c1ccc(CNC(=O)C2C[C@H]2c2ccccc2)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C36H41N5O2/c1-23-18-24(2)41(39-23)28-13-9-12-26(19-28)29-15-14-27(21-37-34(42)32-20-31(32)25-10-7-6-8-11-25)33-22-40(17-16-30(29)33)35(43)38-36(3,4)5/h6-15,18-19,31-32H,16-17,20-22H2,1-5H3,(H,37,42)(H,38,43)/t31-,32?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435347
PNG
((trans)-N-((2-(2-((3R,5R)-3,5- dimethylmorpholino)...)
Show SMILES C[C@@H]1COC[C@@H](C)N1C(=O)CN1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1nc(C)no1)ccc2-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C32H36F3N5O5/c1-18-16-43-17-19(2)40(18)29(41)15-39-10-9-25-24(21-5-4-6-23(11-21)44-32(33,34)35)8-7-22(28(25)14-39)13-36-30(42)26-12-27(26)31-37-20(3)38-45-31/h4-8,11,18-19,26-27H,9-10,12-17H2,1-3H3,(H,36,42)/t18-,19-,26?,27-/m1/s1
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n/an/a 7.38E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435281
PNG
(N-(tert-butyl)-5-(1-oxoisoindolin-4- yl)-8-(((tran...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc2C(=O)NCc12
Show InChI InChI=1S/C33H36N4O3/c1-33(2,3)36-32(40)37-15-14-24-23(22-10-7-11-25-28(22)18-35-30(25)38)13-12-21(29(24)19-37)17-34-31(39)27-16-26(27)20-8-5-4-6-9-20/h4-13,26-27H,14-19H2,1-3H3,(H,34,39)(H,35,38)(H,36,40)/t26-,27?/m0/s1
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n/an/a 7.48E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM435326
PNG
(2-(3-methyl-1,2,4-oxadiazol-5-yl)-N-((2- (2-oxo-2-...)
Show SMILES C[C@@H](NC(=O)CN1CCc2c(C1)c(CNC(=O)C1CC1c1nc(C)no1)ccc2-c1cccc(OC(F)(F)F)c1)c1ccccc1
Show InChI InChI=1S/C34H34F3N5O4/c1-20(22-7-4-3-5-8-22)39-31(43)19-42-14-13-27-26(23-9-6-10-25(15-23)45-34(35,36)37)12-11-24(30(27)18-42)17-38-32(44)28-16-29(28)33-40-21(2)41-46-33/h3-12,15,20,28-29H,13-14,16-19H2,1-2H3,(H,38,44)(H,39,43)/t20-,28?,29?/m1/s1
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n/an/a 7.60E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%