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Patent code US10568888

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135819
PNG
(US10085990, Example 103 | US10568888, Example 103 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)C(O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H22ClN3O5/c1-34-20-7-3-6-18-21(20)27-13-19-22(18)28(16-10-8-14(9-11-16)24(31)32)25(33)29(23(19)30)17-5-2-4-15(26)12-17/h2-7,12-14,16H,8-11H2,1H3,(H,31,32)/t14-,16?
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135824
PNG
(US10085990, Example 127 | US10568888, Example 127 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)NS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O5S/c1-35-21-8-4-7-19-22(21)27-14-20-23(19)29(17-11-9-16(10-12-17)28-36(2,33)34)25(32)30(24(20)31)18-6-3-5-15(26)13-18/h3-8,13-14,16-17,28H,9-12H2,1-2H3/t16-,17?
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135822
PNG
(US10085990, Example 121 | US10568888, Example 121 ...)
Show SMILES CCS(=O)(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O5S/c1-3-36(33,34)28-12-10-17(11-13-28)29-23-19-8-5-9-21(35-2)22(19)27-15-20(23)24(31)30(25(29)32)18-7-4-6-16(26)14-18/h4-9,14-15,17H,3,10-13H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135823
PNG
(US10085990, Example 122 | US10568888, Example 122 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O7S2/c1-37-21-8-4-7-19-22(21)27-14-20-23(19)29(25(32)30(24(20)31)18-6-3-5-16(26)13-18)17-9-11-28(12-10-17)39(35,36)15-38(2,33)34/h3-8,13-14,17H,9-12,15H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135820
PNG
(US10085990, Example 115 | US10568888, Example 115 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m1/s1
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135819
PNG
(US10085990, Example 103 | US10568888, Example 103 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)C(O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H22ClN3O5/c1-34-20-7-3-6-18-21(20)27-13-19-22(18)28(16-10-8-14(9-11-16)24(31)32)25(33)29(23(19)30)17-5-2-4-15(26)12-17/h2-7,12-14,16H,8-11H2,1H3,(H,31,32)/t14-,16?
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135822
PNG
(US10085990, Example 121 | US10568888, Example 121 ...)
Show SMILES CCS(=O)(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O5S/c1-3-36(33,34)28-12-10-17(11-13-28)29-23-19-8-5-9-21(35-2)22(19)27-15-20(23)24(31)30(25(29)32)18-7-4-6-16(26)14-18/h4-9,14-15,17H,3,10-13H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135818
PNG
(US10085990, Example 92 | US10568888, Example 92 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C24H23ClN4O5S/c1-34-20-8-4-7-18-21(20)26-14-19-22(18)28(16-9-11-27(12-10-16)35(2,32)33)24(31)29(23(19)30)17-6-3-5-15(25)13-17/h3-8,13-14,16H,9-12H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135824
PNG
(US10085990, Example 127 | US10568888, Example 127 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)NS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O5S/c1-35-21-8-4-7-19-22(21)27-14-20-23(19)29(17-11-9-16(10-12-17)28-36(2,33)34)25(32)30(24(20)31)18-6-3-5-15(26)13-18/h3-8,13-14,16-17,28H,9-12H2,1-2H3/t16-,17?
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135816
PNG
(US10085990, Example 54 | US10568888, Example 54 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(C)c2)c1=O
Show InChI InChI=1S/C24H23N3O3/c1-15-7-5-10-17(13-15)27-23(28)19-14-25-21-18(11-6-12-20(21)30-2)22(19)26(24(27)29)16-8-3-4-9-16/h5-7,10-14,16H,3-4,8-9H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135823
PNG
(US10085990, Example 122 | US10568888, Example 122 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O7S2/c1-37-21-8-4-7-19-22(21)27-14-20-23(19)29(25(32)30(24(20)31)18-6-3-5-16(26)13-18)17-9-11-28(12-10-17)39(35,36)15-38(2,33)34/h3-8,13-14,17H,9-12,15H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135821
PNG
(US10085990, Example 118 | US10568888, Example 118 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m0/s1
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135815
PNG
(US10085990, Example 51 | US10568888, Example 51 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cc(C)cs2)c1=O
Show InChI InChI=1S/C22H21N3O3S/c1-13-10-18(29-12-13)25-21(26)16-11-23-19-15(8-5-9-17(19)28-2)20(16)24(22(25)27)14-6-3-4-7-14/h5,8-12,14H,3-4,6-7H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135818
PNG
(US10085990, Example 92 | US10568888, Example 92 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C24H23ClN4O5S/c1-34-20-8-4-7-18-21(20)26-14-19-22(18)28(16-9-11-27(12-10-16)35(2,32)33)24(31)29(23(19)30)17-6-3-5-15(25)13-17/h3-8,13-14,16H,9-12H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135820
PNG
(US10085990, Example 115 | US10568888, Example 115 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m1/s1
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135821
PNG
(US10085990, Example 118 | US10568888, Example 118 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m0/s1
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135816
PNG
(US10085990, Example 54 | US10568888, Example 54 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(C)c2)c1=O
Show InChI InChI=1S/C24H23N3O3/c1-15-7-5-10-17(13-15)27-23(28)19-14-25-21-18(11-6-12-20(21)30-2)22(19)26(24(27)29)16-8-3-4-9-16/h5-7,10-14,16H,3-4,8-9H2,1-2H3
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n/an/a 338n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135817
PNG
(US10085990, Example 84 | US10568888, Example 84 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2ccc3OCOc3c2)c1=O
Show InChI InChI=1S/C24H21N3O5/c1-30-19-8-4-7-16-21(19)25-12-17-22(16)26(14-5-2-3-6-14)24(29)27(23(17)28)15-9-10-18-20(11-15)32-13-31-18/h4,7-12,14H,2-3,5-6,13H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135815
PNG
(US10085990, Example 51 | US10568888, Example 51 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cc(C)cs2)c1=O
Show InChI InChI=1S/C22H21N3O3S/c1-13-10-18(29-12-13)25-21(26)16-11-23-19-15(8-5-9-17(19)28-2)20(16)24(22(25)27)14-6-3-4-7-14/h5,8-12,14H,3-4,6-7H2,1-2H3
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n/an/a 616n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135817
PNG
(US10085990, Example 84 | US10568888, Example 84 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2ccc3OCOc3c2)c1=O
Show InChI InChI=1S/C24H21N3O5/c1-30-19-8-4-7-16-21(19)25-12-17-22(16)26(14-5-2-3-6-14)24(29)27(23(17)28)15-9-10-18-20(11-15)32-13-31-18/h4,7-12,14H,2-3,5-6,13H2,1H3
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n/an/a 827n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135814
PNG
(US10085990, Example 33 | US10568888, Example 33 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(C(C)C)c3ncc2c1=O
Show InChI InChI=1S/C21H25N3O2/c1-4-23-20(25)17-12-22-18-15(13(2)3)10-7-11-16(18)19(17)24(21(23)26)14-8-5-6-9-14/h7,10-14H,4-6,8-9H2,1-3H3
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n/an/a 1.24E+4n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135812
PNG
(US10085990, Example 30 | US10568888, Example 30 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O
Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135813
PNG
(US10085990, Example 32 | US10568888, Example 32 | ...)
Show SMILES CCCc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(CC)c1=O
Show InChI InChI=1S/C21H25N3O2/c1-3-8-14-9-7-12-16-18(14)22-13-17-19(16)24(15-10-5-6-11-15)21(26)23(4-2)20(17)25/h7,9,12-13,15H,3-6,8,10-11H2,1-2H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135814
PNG
(US10085990, Example 33 | US10568888, Example 33 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(C(C)C)c3ncc2c1=O
Show InChI InChI=1S/C21H25N3O2/c1-4-23-20(25)17-12-22-18-15(13(2)3)10-7-11-16(18)19(17)24(21(23)26)14-8-5-6-9-14/h7,10-14H,4-6,8-9H2,1-3H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135813
PNG
(US10085990, Example 32 | US10568888, Example 32 | ...)
Show SMILES CCCc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(CC)c1=O
Show InChI InChI=1S/C21H25N3O2/c1-3-8-14-9-7-12-16-18(14)22-13-17-19(16)24(15-10-5-6-11-15)21(26)23(4-2)20(17)25/h7,9,12-13,15H,3-6,8,10-11H2,1-2H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM135812
PNG
(US10085990, Example 30 | US10568888, Example 30 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O
Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...

US Patent US10568888 (2020)


BindingDB Entry DOI: 10.7270/Q2ST7S7B
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%