BindingDB logo
myBDB logout

Patent code US10570077

Compile Data Set for Download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM50494960
PNG
(CHEMBL3099430 | US10570077, Compound 7)
Show SMILES CC[C@H](C)C1=CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
Show InChI InChI=1S/C22H30O/c1-4-14(2)20-9-10-21-19-7-5-15-13-16(23)6-8-17(15)18(19)11-12-22(20,21)3/h6,8-9,13-14,18-19,21,23H,4-5,7,10-12H2,1-3H3/t14-,18+,19+,21-,22+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/a 160n/an/an/an/an/a



Marquette University; Concordia University Inc.

US Patent


Assay Description
Twelve compounds from Schemes 1 and 2 were screened using fluorescence polarization, for their ability to bind ERα (Table 1). Only six compounds...


US Patent US10570077 (2020)


BindingDB Entry DOI: 10.7270/Q2P271H9
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM50494963
PNG
(CHEMBL3099431 | US10570077, Compound 13)
Show SMILES CC1C[C@H](C)C2(CC[C@H]3[C@@H]4CCc5cc(O)ccc5[C@H]4CC[C@]23C)O1
Show InChI InChI=1S/C23H32O2/c1-14-12-15(2)25-23(14)11-9-21-20-6-4-16-13-17(24)5-7-18(16)19(20)8-10-22(21,23)3/h5,7,13-15,19-21,24H,4,6,8-12H2,1-3H3/t14-,15?,19+,20+,21-,22-,23?/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/a 160n/an/an/an/an/a



Marquette University; Concordia University Inc.

US Patent


Assay Description
Twelve compounds from Schemes 1 and 2 were screened using fluorescence polarization, for their ability to bind ERα (Table 1). Only six compounds...


US Patent US10570077 (2020)


BindingDB Entry DOI: 10.7270/Q2P271H9
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM435391
PNG
(US10570077, Compound 2)
Show SMILES CC1=CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
Show InChI InChI=1S/C19H24O/c1-12-3-8-18-17-6-4-13-11-14(20)5-7-15(13)16(17)9-10-19(12,18)2/h3,5,7,11,16-18,20H,4,6,8-10H2,1-2H3/t16-,17-,18+,19-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/a 32n/an/an/an/an/a



Marquette University; Concordia University Inc.

US Patent


Assay Description
Twelve compounds from Schemes 1 and 2 were screened using fluorescence polarization, for their ability to bind ERα (Table 1). Only six compounds...


US Patent US10570077 (2020)


BindingDB Entry DOI: 10.7270/Q2P271H9
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM435383
PNG
(US10570077, Compound E2)
Show SMILES CC12CC[C@H]3C(CCc4cc(O)ccc34)[C@@H]1CCC2O
Show InChI InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15?,16+,17?,18?/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/a 3n/an/an/an/an/a



Marquette University; Concordia University Inc.

US Patent


Assay Description
Twelve compounds from Schemes 1 and 2 were screened using fluorescence polarization, for their ability to bind ERα (Table 1). Only six compounds...


US Patent US10570077 (2020)


BindingDB Entry DOI: 10.7270/Q2P271H9
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM435385
PNG
(US10570077, Compound 4)
Show SMILES CCCOC(=O)C1=CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
Show InChI InChI=1S/C22H28O3/c1-3-12-25-21(24)20-9-8-19-18-6-4-14-13-15(23)5-7-16(14)17(18)10-11-22(19,20)2/h5,7,9,13,17-19,23H,3-4,6,8,10-12H2,1-2H3/t17-,18-,19+,22+/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/a 320n/an/an/an/an/a



Marquette University; Concordia University Inc.

US Patent


Assay Description
Twelve compounds from Schemes 1 and 2 were screened using fluorescence polarization, for their ability to bind ERα (Table 1). Only six compounds...


US Patent US10570077 (2020)


BindingDB Entry DOI: 10.7270/Q2P271H9
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM435392
PNG
(US10570077, Compound 18)
Show SMILES OC[C@H]1C=CC[C@H](C=C1)c1ccc(O)cc1
Show InChI InChI=1S/C14H16O2/c15-10-11-2-1-3-12(5-4-11)13-6-8-14(16)9-7-13/h1-2,4-9,11-12,15-16H,3,10H2/t11-,12+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/an/a>1.00E+3n/an/an/an/an/a



Marquette University; Concordia University Inc.

US Patent


Assay Description
Twelve compounds from Schemes 1 and 2 were screened using fluorescence polarization, for their ability to bind ERα (Table 1). Only six compounds...


US Patent US10570077 (2020)


BindingDB Entry DOI: 10.7270/Q2P271H9
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2/Estrogen receptor


(Homo sapiens (Human))
BDBM50494961
PNG
(CHEMBL3099428 | US10570077, Compound 11)
Show SMILES C[C@@H](CCO)C1=CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
Show InChI InChI=1S/C22H30O2/c1-14(10-12-23)20-7-8-21-19-5-3-15-13-16(24)4-6-17(15)18(19)9-11-22(20,21)2/h4,6-7,13-14,18-19,21,23-24H,3,5,8-12H2,1-2H3/t14-,18+,19+,21-,22+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/a 320n/an/an/an/an/a



Marquette University; Concordia University Inc.

US Patent


Assay Description
Twelve compounds from Schemes 1 and 2 were screened using fluorescence polarization, for their ability to bind ERα (Table 1). Only six compounds...


US Patent US10570077 (2020)


BindingDB Entry DOI: 10.7270/Q2P271H9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%