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Patent code US10570116

Compile Data Set for Download or QSAR
Found 153 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435386
PNG
(US10570116, Compound C2)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H27N5O3/c1-15(11-20-25-19-6-4-3-5-18(19)23(31)26-20)12-21(29)28-9-7-16(8-10-28)22(30)17-13-24-27(2)14-17/h3-6,13-16H,7-12H2,1-2H3,(H,25,26,31)/t15-/m0/s1
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n/an/a 0.190n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435395
PNG
(US10570116, Compound C6)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H28FN5O3/c1-14(8-20-27-22-15(2)10-18(25)11-19(22)24(33)28-20)9-21(31)30-6-4-16(5-7-30)23(32)17-12-26-29(3)13-17/h10-14,16H,4-9H2,1-3H3,(H,27,28,33)/t14-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435441
PNG
(US10570116, Compound C49)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H30N4O3/c1-25(2,13-20-12-18-6-4-5-7-21(18)24(32)27-20)14-22(30)29-10-8-17(9-11-29)23(31)19-15-26-28(3)16-19/h4-7,12,15-17H,8-11,13-14H2,1-3H3,(H,27,32)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435439
PNG
(US10570116, Compound C47)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C27H28FN3O5/c1-15(10-22-29-24-16(2)12-20(28)14-21(24)26(34)30-22)11-23(32)31-8-6-17(7-9-31)25(33)18-4-3-5-19(13-18)27(35)36/h3-5,12-15,17H,6-11H2,1-2H3,(H,35,36)(H,29,30,34)/t15-/m0/s1
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n/an/a 0.220n/an/an/an/an/an/a



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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435435
PNG
(US10570116, Compound C43)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)C[C@@H](C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-17(14-23-29-25-18(2)6-4-9-22(25)27(34)30-23)15-24(32)31-12-10-19(11-13-31)26(33)20-7-5-8-21(16-20)28(35)36-3/h4-9,16-17,19H,10-15H2,1-3H3,(H,29,30,34)/t17-/m0/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435442
PNG
(US10570116, Compound C50)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H28N4O3/c1-16(11-20-13-18-5-3-4-6-21(18)24(31)26-20)12-22(29)28-9-7-17(8-10-28)23(30)19-14-25-27(2)15-19/h3-6,13-17H,7-12H2,1-2H3,(H,26,31)/t16-/m0/s1
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n/an/a 0.240n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435444
PNG
(US10570116, Compound C52)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C(O)=O)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H30N2O5/c1-28(2,16-22-15-21-5-3-4-6-23(21)26(33)29-22)17-24(31)30-13-11-19(12-14-30)25(32)18-7-9-20(10-8-18)27(34)35/h3-10,15,19H,11-14,16-17H2,1-2H3,(H,29,33)(H,34,35)
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n/an/a 0.25n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435441
PNG
(US10570116, Compound C49)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H30N4O3/c1-25(2,13-20-12-18-6-4-5-7-21(18)24(32)27-20)14-22(30)29-10-8-17(9-11-29)23(31)19-15-26-28(3)16-19/h4-7,12,15-17H,8-11,13-14H2,1-3H3,(H,27,32)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435395
PNG
(US10570116, Compound C6)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H28FN5O3/c1-14(8-20-27-22-15(2)10-18(25)11-19(22)24(33)28-20)9-21(31)30-6-4-16(5-7-30)23(32)17-12-26-29(3)13-17/h10-14,16H,4-9H2,1-3H3,(H,27,28,33)/t14-/m0/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435430
PNG
(US10570116, Compound C38)
Show SMILES COC(=O)c1ccc(cc1C)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C29H33N3O5/c1-18-15-20(9-10-21(18)28(36)37-4)26(34)19-11-13-32(14-12-19)25(33)17-29(2,3)16-24-30-23-8-6-5-7-22(23)27(35)31-24/h5-10,15,19H,11-14,16-17H2,1-4H3,(H,30,31,35)
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n/an/a 0.320n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435386
PNG
(US10570116, Compound C2)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H27N5O3/c1-15(11-20-25-19-6-4-3-5-18(19)23(31)26-20)12-21(29)28-9-7-16(8-10-28)22(30)17-13-24-27(2)14-17/h3-6,13-16H,7-12H2,1-2H3,(H,25,26,31)/t15-/m0/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435409
PNG
(US10570116, Compound C17)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C23H30N6O3/c1-23(2,11-18-25-21-17(22(32)26-18)7-8-27(21)3)12-19(30)29-9-5-15(6-10-29)20(31)16-13-24-28(4)14-16/h7-8,13-15H,5-6,9-12H2,1-4H3,(H,25,26,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435444
PNG
(US10570116, Compound C52)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C(O)=O)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H30N2O5/c1-28(2,16-22-15-21-5-3-4-6-23(21)26(33)29-22)17-24(31)30-13-11-19(12-14-30)25(32)18-7-9-20(10-8-18)27(34)35/h3-10,15,19H,11-14,16-17H2,1-2H3,(H,29,33)(H,34,35)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435439
PNG
(US10570116, Compound C47)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C27H28FN3O5/c1-15(10-22-29-24-16(2)12-20(28)14-21(24)26(34)30-22)11-23(32)31-8-6-17(7-9-31)25(33)18-4-3-5-19(13-18)27(35)36/h3-5,12-15,17H,6-11H2,1-2H3,(H,35,36)(H,29,30,34)/t15-/m0/s1
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n/an/a 0.350n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435410
PNG
(US10570116, Compound C18)
Show SMILES CCn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C24H32N6O3/c1-5-30-15-17(14-25-30)21(32)16-6-10-29(11-7-16)20(31)13-24(2,3)12-19-26-22-18(23(33)27-19)8-9-28(22)4/h8-9,14-16H,5-7,10-13H2,1-4H3,(H,26,27,33)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435384
PNG
(US10570116, Compound C1)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,12-20-26-19-7-5-4-6-18(19)23(32)27-20)13-21(30)29-10-8-16(9-11-29)22(31)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435403
PNG
(US10570116, Compound C11)
Show SMILES CC(C)C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C26H33N5O3/c1-17(2)12-18(13-23-28-22-7-5-4-6-21(22)26(34)29-23)14-24(32)31-10-8-19(9-11-31)25(33)20-15-27-30(3)16-20/h4-7,15-19H,8-14H2,1-3H3,(H,28,29,34)/t18-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435408
PNG
(US10570116, Compound C16)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O4/c1-25(2,13-19-27-23-18(24(33)28-19)9-10-29(23)3)14-21(31)30-11-7-16(8-12-30)22(32)17-5-6-20(34-4)26-15-17/h5-6,9-10,15-16H,7-8,11-14H2,1-4H3,(H,27,28,33)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435431
PNG
(US10570116, Compound C39)
Show SMILES Cc1cc(ccc1C(O)=O)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-17-14-19(8-9-20(17)27(35)36)25(33)18-10-12-31(13-11-18)24(32)16-28(2,3)15-23-29-22-7-5-4-6-21(22)26(34)30-23/h4-9,14,18H,10-13,15-16H2,1-3H3,(H,35,36)(H,29,30,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435442
PNG
(US10570116, Compound C50)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H28N4O3/c1-16(11-20-13-18-5-3-4-6-21(18)24(31)26-20)12-22(29)28-9-7-17(8-10-28)23(30)19-14-25-27(2)15-19/h3-6,13-17H,7-12H2,1-2H3,(H,26,31)/t16-/m0/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435425
PNG
(US10570116, Compound C33)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C(O)=O)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-27(2,15-22-28-21-6-4-3-5-20(21)25(33)29-22)16-23(31)30-13-11-18(12-14-30)24(32)17-7-9-19(10-8-17)26(34)35/h3-10,18H,11-16H2,1-2H3,(H,34,35)(H,28,29,33)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435437
PNG
(US10570116, Compound C45)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-16(13-22-28-24-17(2)5-3-8-21(24)26(33)29-22)14-23(31)30-11-9-18(10-12-30)25(32)19-6-4-7-20(15-19)27(34)35/h3-8,15-16,18H,9-14H2,1-2H3,(H,34,35)(H,28,29,33)/t16-/m0/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435434
PNG
(US10570116, Compound C42)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)C[C@H](C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-17(14-23-29-25-18(2)6-4-9-22(25)27(34)30-23)15-24(32)31-12-10-19(11-13-31)26(33)20-7-5-8-21(16-20)28(35)36-3/h4-9,16-17,19H,10-15H2,1-3H3,(H,29,30,34)/t17-/m1/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435393
PNG
(US10570116, Compound C4)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(c1)C(C)C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)30-15-19(14-26-30)24(32)18-8-10-29(11-9-18)23(31)13-17(3)12-22-27-21-7-5-4-6-20(21)25(33)28-22/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t17-/m0/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435409
PNG
(US10570116, Compound C17)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C23H30N6O3/c1-23(2,11-18-25-21-17(22(32)26-18)7-8-27(21)3)12-19(30)29-9-5-15(6-10-29)20(31)16-13-24-28(4)14-16/h7-8,13-15H,5-6,9-12H2,1-4H3,(H,25,26,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435426
PNG
(US10570116, Compound C34)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-28(2,16-23-29-22-10-5-4-9-21(22)26(34)30-23)17-24(32)31-13-11-18(12-14-31)25(33)19-7-6-8-20(15-19)27(35)36-3/h4-10,15,18H,11-14,16-17H2,1-3H3,(H,29,30,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435399
PNG
(US10570116, Compound C8)
Show SMILES CC(C)[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)18(12-22-27-21-7-5-4-6-20(21)25(33)28-22)13-23(31)30-10-8-17(9-11-30)24(32)19-14-26-29(3)15-19/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t18-/m0/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435426
PNG
(US10570116, Compound C34)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-28(2,16-23-29-22-10-5-4-9-21(22)26(34)30-23)17-24(32)31-13-11-18(12-14-31)25(33)19-7-6-8-20(15-19)27(35)36-3/h4-10,15,18H,11-14,16-17H2,1-3H3,(H,29,30,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435425
PNG
(US10570116, Compound C33)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C(O)=O)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-27(2,15-22-28-21-6-4-3-5-20(21)25(33)29-22)16-23(31)30-13-11-18(12-14-30)24(32)17-7-9-19(10-8-17)26(34)35/h3-10,18H,11-16H2,1-2H3,(H,34,35)(H,28,29,33)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435403
PNG
(US10570116, Compound C11)
Show SMILES CC(C)C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C26H33N5O3/c1-17(2)12-18(13-23-28-22-7-5-4-6-21(22)26(34)29-23)14-24(32)31-10-8-19(9-11-31)25(33)20-15-27-30(3)16-20/h4-7,15-19H,8-14H2,1-3H3,(H,28,29,34)/t18-/m1/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435399
PNG
(US10570116, Compound C8)
Show SMILES CC(C)[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)18(12-22-27-21-7-5-4-6-20(21)25(33)28-22)13-23(31)30-10-8-17(9-11-30)24(32)19-14-26-29(3)15-19/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t18-/m0/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435437
PNG
(US10570116, Compound C45)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-16(13-22-28-24-17(2)5-3-8-21(24)26(33)29-22)14-23(31)30-11-9-18(10-12-30)25(32)19-6-4-7-20(15-19)27(34)35/h3-8,15-16,18H,9-14H2,1-2H3,(H,34,35)(H,28,29,33)/t16-/m0/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435424
PNG
(US10570116, Compound C32)
Show SMILES COC(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-28(2,16-23-29-22-7-5-4-6-21(22)26(34)30-23)17-24(32)31-14-12-19(13-15-31)25(33)18-8-10-20(11-9-18)27(35)36-3/h4-11,19H,12-17H2,1-3H3,(H,29,30,34)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435384
PNG
(US10570116, Compound C1)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,12-20-26-19-7-5-4-6-18(19)23(32)27-20)13-21(30)29-10-8-16(9-11-29)22(31)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435422
PNG
(US10570116, Compound C30)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)N(C)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H28N4O4/c1-28(14-13-22-26-21-6-4-3-5-20(21)24(31)27-22)25(32)29-15-11-18(12-16-29)23(30)17-7-9-19(33-2)10-8-17/h3-10,18H,11-16H2,1-2H3,(H,26,27,31)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435410
PNG
(US10570116, Compound C18)
Show SMILES CCn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C24H32N6O3/c1-5-30-15-17(14-25-30)21(32)16-6-10-29(11-7-16)20(31)13-24(2,3)12-19-26-22-18(23(33)27-19)8-9-28(22)4/h8-9,14-16H,5-7,10-13H2,1-4H3,(H,26,27,33)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435411
PNG
(US10570116, Compound C19)
Show SMILES CC(C)n1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C25H34N6O3/c1-16(2)31-15-18(14-26-31)22(33)17-6-10-30(11-7-17)21(32)13-25(3,4)12-20-27-23-19(24(34)28-20)8-9-29(23)5/h8-9,14-17H,6-7,10-13H2,1-5H3,(H,27,28,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435430
PNG
(US10570116, Compound C38)
Show SMILES COC(=O)c1ccc(cc1C)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C29H33N3O5/c1-18-15-20(9-10-21(18)28(36)37-4)26(34)19-11-13-32(14-12-19)25(33)17-29(2,3)16-24-30-23-8-6-5-7-22(23)27(35)31-24/h5-10,15,19H,11-14,16-17H2,1-4H3,(H,30,31,35)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435396
PNG
(US10570116, Compound C7)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H28FN5O3/c1-14(8-20-27-22-15(2)10-18(25)11-19(22)24(33)28-20)9-21(31)30-6-4-16(5-7-30)23(32)17-12-26-29(3)13-17/h10-14,16H,4-9H2,1-3H3,(H,27,28,33)/t14-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435433
PNG
(US10570116, Compound C41)
Show SMILES Cc1cc(ccc1C(O)=O)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C29H33N3O5/c1-17-6-5-7-22-25(17)30-23(31-27(22)35)15-29(3,4)16-24(33)32-12-10-19(11-13-32)26(34)20-8-9-21(28(36)37)18(2)14-20/h5-9,14,19H,10-13,15-16H2,1-4H3,(H,36,37)(H,30,31,35)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435431
PNG
(US10570116, Compound C39)
Show SMILES Cc1cc(ccc1C(O)=O)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-17-14-19(8-9-20(17)27(35)36)25(33)18-10-12-31(13-11-18)24(32)16-28(2,3)15-23-29-22-7-5-4-6-21(22)26(34)30-23/h4-9,14,18H,10-13,15-16H2,1-3H3,(H,35,36)(H,29,30,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435408
PNG
(US10570116, Compound C16)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O4/c1-25(2,13-19-27-23-18(24(33)28-19)9-10-29(23)3)14-21(31)30-11-7-16(8-12-30)22(32)17-5-6-20(34-4)26-15-17/h5-6,9-10,15-16H,7-8,11-14H2,1-4H3,(H,27,28,33)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435422
PNG
(US10570116, Compound C30)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)N(C)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H28N4O4/c1-28(14-13-22-26-21-6-4-3-5-20(21)24(31)27-22)25(32)29-15-11-18(12-16-29)23(30)17-7-9-19(33-2)10-8-17/h3-10,18H,11-16H2,1-2H3,(H,26,27,31)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435435
PNG
(US10570116, Compound C43)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)C[C@@H](C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-17(14-23-29-25-18(2)6-4-9-22(25)27(34)30-23)15-24(32)31-12-10-19(11-13-31)26(33)20-7-5-8-21(16-20)28(35)36-3/h4-9,16-17,19H,10-15H2,1-3H3,(H,29,30,34)/t17-/m0/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435396
PNG
(US10570116, Compound C7)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H28FN5O3/c1-14(8-20-27-22-15(2)10-18(25)11-19(22)24(33)28-20)9-21(31)30-6-4-16(5-7-30)23(32)17-12-26-29(3)13-17/h10-14,16H,4-9H2,1-3H3,(H,27,28,33)/t14-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435424
PNG
(US10570116, Compound C32)
Show SMILES COC(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-28(2,16-23-29-22-7-5-4-6-21(22)26(34)30-23)17-24(32)31-14-12-19(13-15-31)25(33)18-8-10-20(11-9-18)27(35)36-3/h4-11,19H,12-17H2,1-3H3,(H,29,30,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435445
PNG
(US10570116, Compound C53)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H30N2O5/c1-28(2,16-22-15-19-6-3-4-9-23(19)26(33)29-22)17-24(31)30-12-10-18(11-13-30)25(32)20-7-5-8-21(14-20)27(34)35/h3-9,14-15,18H,10-13,16-17H2,1-2H3,(H,29,33)(H,34,35)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435443
PNG
(US10570116, Compound C51)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H28N4O3/c1-16(11-20-13-18-5-3-4-6-21(18)24(31)26-20)12-22(29)28-9-7-17(8-10-28)23(30)19-14-25-27(2)15-19/h3-6,13-17H,7-12H2,1-2H3,(H,26,31)/t16-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435412
PNG
(US10570116, Compound C20)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C22H29N7O3/c1-22(2,9-17-25-20-16(21(32)26-17)12-24-28(20)4)10-18(30)29-7-5-14(6-8-29)19(31)15-11-23-27(3)13-15/h11-14H,5-10H2,1-4H3,(H,25,26,32)
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n/an/a 0.730n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435428
PNG
(US10570116, Compound C36)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C29H33N3O5/c1-18-7-5-10-22-25(18)30-23(31-27(22)35)16-29(2,3)17-24(33)32-13-11-19(12-14-32)26(34)20-8-6-9-21(15-20)28(36)37-4/h5-10,15,19H,11-14,16-17H2,1-4H3,(H,30,31,35)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435421
PNG
(US10570116, Compound C29)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)NCCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H26N4O4/c1-32-18-8-6-16(7-9-18)22(29)17-11-14-28(15-12-17)24(31)25-13-10-21-26-20-5-3-2-4-19(20)23(30)27-21/h2-9,17H,10-15H2,1H3,(H,25,31)(H,26,27,30)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435393
PNG
(US10570116, Compound C4)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(c1)C(C)C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)30-15-19(14-26-30)24(32)18-8-10-29(11-9-18)23(31)13-17(3)12-22-27-21-7-5-4-6-20(21)25(33)28-22/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t17-/m0/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435433
PNG
(US10570116, Compound C41)
Show SMILES Cc1cc(ccc1C(O)=O)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C29H33N3O5/c1-17-6-5-7-22-25(17)30-23(31-27(22)35)15-29(3,4)16-24(33)32-12-10-19(11-13-32)26(34)20-8-9-21(28(36)37)18(2)14-20/h5-9,14,19H,10-13,15-16H2,1-4H3,(H,36,37)(H,30,31,35)
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n/an/a 0.880n/an/an/an/an/an/a



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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435412
PNG
(US10570116, Compound C20)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C22H29N7O3/c1-22(2,9-17-25-20-16(21(32)26-17)12-24-28(20)4)10-18(30)29-7-5-14(6-8-29)19(31)15-11-23-27(3)13-15/h11-14H,5-10H2,1-4H3,(H,25,26,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435429
PNG
(US10570116, Compound C37)
Show SMILES Cc1cccc2c1nc(CC(C)(C)CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)[nH]c2=O
Show InChI InChI=1S/C28H31N3O5/c1-17-6-4-9-21-24(17)29-22(30-26(21)34)15-28(2,3)16-23(32)31-12-10-18(11-13-31)25(33)19-7-5-8-20(14-19)27(35)36/h4-9,14,18H,10-13,15-16H2,1-3H3,(H,35,36)(H,29,30,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435434
PNG
(US10570116, Compound C42)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)C[C@H](C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-17(14-23-29-25-18(2)6-4-9-22(25)27(34)30-23)15-24(32)31-12-10-19(11-13-31)26(33)20-7-5-8-21(16-20)28(35)36-3/h4-9,16-17,19H,10-15H2,1-3H3,(H,29,30,34)/t17-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435404
PNG
(US10570116, Compound C12)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC1(Cc2nc3ccccc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C24H27N5O3/c1-28-15-17(14-25-28)22(31)16-6-10-29(11-7-16)21(30)13-24(8-9-24)12-20-26-19-5-3-2-4-18(19)23(32)27-20/h2-5,14-16H,6-13H2,1H3,(H,26,27,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435443
PNG
(US10570116, Compound C51)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H28N4O3/c1-16(11-20-13-18-5-3-4-6-21(18)24(31)26-20)12-22(29)28-9-7-17(8-10-28)23(30)19-14-25-27(2)15-19/h3-6,13-17H,7-12H2,1-2H3,(H,26,31)/t16-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435445
PNG
(US10570116, Compound C53)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H30N2O5/c1-28(2,16-22-15-19-6-3-4-9-23(19)26(33)29-22)17-24(31)30-12-10-18(11-13-30)25(32)20-7-5-8-21(14-20)27(34)35/h3-9,14-15,18H,10-13,16-17H2,1-2H3,(H,29,33)(H,34,35)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435411
PNG
(US10570116, Compound C19)
Show SMILES CC(C)n1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C25H34N6O3/c1-16(2)31-15-18(14-26-31)22(33)17-6-10-30(11-7-17)21(32)13-25(3,4)12-20-27-23-19(24(34)28-20)8-9-29(23)5/h8-9,14-17H,6-7,10-13H2,1-5H3,(H,27,28,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435432
PNG
(US10570116, Compound C40)
Show SMILES COC(=O)c1ccc(cc1C)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C30H35N3O5/c1-18-7-6-8-23-26(18)31-24(32-28(23)36)16-30(3,4)17-25(34)33-13-11-20(12-14-33)27(35)21-9-10-22(19(2)15-21)29(37)38-5/h6-10,15,20H,11-14,16-17H2,1-5H3,(H,31,32,36)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435390
PNG
(US10570116, Compound C3)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H27N5O3/c1-15(11-20-25-19-6-4-3-5-18(19)23(31)26-20)12-21(29)28-9-7-16(8-10-28)22(30)17-13-24-27(2)14-17/h3-6,13-16H,7-12H2,1-2H3,(H,25,26,31)/t15-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435414
PNG
(US10570116, Compound C22)
Show SMILES COc1ncc(cc1C)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C25H32N6O4/c1-15-10-17(13-26-24(15)35-5)21(33)16-6-8-31(9-7-16)20(32)12-25(2,3)11-19-28-22-18(23(34)29-19)14-27-30(22)4/h10,13-14,16H,6-9,11-12H2,1-5H3,(H,28,29,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435421
PNG
(US10570116, Compound C29)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)NCCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H26N4O4/c1-32-18-8-6-16(7-9-18)22(29)17-11-14-28(15-12-17)24(31)25-13-10-21-26-20-5-3-2-4-19(20)23(30)27-21/h2-9,17H,10-15H2,1H3,(H,25,31)(H,26,27,30)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435390
PNG
(US10570116, Compound C3)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H27N5O3/c1-15(11-20-25-19-6-4-3-5-18(19)23(31)26-20)12-21(29)28-9-7-16(8-10-28)22(30)17-13-24-27(2)14-17/h3-6,13-16H,7-12H2,1-2H3,(H,25,26,31)/t15-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435429
PNG
(US10570116, Compound C37)
Show SMILES Cc1cccc2c1nc(CC(C)(C)CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)[nH]c2=O
Show InChI InChI=1S/C28H31N3O5/c1-17-6-4-9-21-24(17)29-22(30-26(21)34)15-28(2,3)16-23(32)31-12-10-18(11-13-31)25(33)19-7-5-8-20(14-19)27(35)36/h4-9,14,18H,10-13,15-16H2,1-3H3,(H,35,36)(H,29,30,34)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435413
PNG
(US10570116, Compound C21)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C24H30N6O4/c1-24(2,11-18-27-22-17(23(33)28-18)14-26-29(22)3)12-20(31)30-9-7-15(8-10-30)21(32)16-5-6-19(34-4)25-13-16/h5-6,13-15H,7-12H2,1-4H3,(H,27,28,33)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435415
PNG
(US10570116, Compound C23)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H25N3O5/c1-31-18-8-6-16(7-9-18)23(29)17-10-12-27(13-11-17)22(28)15-32-14-21-25-20-5-3-2-4-19(20)24(30)26-21/h2-9,17H,10-15H2,1H3,(H,25,26,30)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435428
PNG
(US10570116, Compound C36)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C29H33N3O5/c1-18-7-5-10-22-25(18)30-23(31-27(22)35)16-29(2,3)17-24(33)32-13-11-19(12-14-32)26(34)20-8-6-9-21(15-20)28(36)37-4/h5-10,15,19H,11-14,16-17H2,1-4H3,(H,30,31,35)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435423
PNG
(US10570116, Compound C31)
Show SMILES CN(CCc1nc2ccccc2c(=O)[nH]1)C(=O)N1CCC(CC1)C(=O)c1cnn(C)c1
Show InChI InChI=1S/C22H26N6O3/c1-26(10-9-19-24-18-6-4-3-5-17(18)21(30)25-19)22(31)28-11-7-15(8-12-28)20(29)16-13-23-27(2)14-16/h3-6,13-15H,7-12H2,1-2H3,(H,24,25,30)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435404
PNG
(US10570116, Compound C12)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC1(Cc2nc3ccccc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C24H27N5O3/c1-28-15-17(14-25-28)22(31)16-6-10-29(11-7-16)21(30)13-24(8-9-24)12-20-26-19-5-3-2-4-18(19)23(32)27-20/h2-5,14-16H,6-13H2,1H3,(H,26,27,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435414
PNG
(US10570116, Compound C22)
Show SMILES COc1ncc(cc1C)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C25H32N6O4/c1-15-10-17(13-26-24(15)35-5)21(33)16-6-8-31(9-7-16)20(32)12-25(2,3)11-19-28-22-18(23(34)29-19)14-27-30(22)4/h10,13-14,16H,6-9,11-12H2,1-5H3,(H,28,29,34)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435438
PNG
(US10570116, Compound C46)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C27H28FN3O5/c1-15(10-22-29-24-16(2)12-20(28)14-21(24)26(34)30-22)11-23(32)31-8-6-17(7-9-31)25(33)18-4-3-5-19(13-18)27(35)36/h3-5,12-15,17H,6-11H2,1-2H3,(H,35,36)(H,29,30,34)/t15-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435423
PNG
(US10570116, Compound C31)
Show SMILES CN(CCc1nc2ccccc2c(=O)[nH]1)C(=O)N1CCC(CC1)C(=O)c1cnn(C)c1
Show InChI InChI=1S/C22H26N6O3/c1-26(10-9-19-24-18-6-4-3-5-17(18)21(30)25-19)22(31)28-11-7-15(8-12-28)20(29)16-13-23-27(2)14-16/h3-6,13-15H,7-12H2,1-2H3,(H,24,25,30)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435418
PNG
(US10570116, Compound C26)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H23F2N3O5/c1-33-17-4-2-14(3-5-17)23(31)15-6-8-29(9-7-15)21(30)13-34-12-20-27-22-18(24(32)28-20)10-16(25)11-19(22)26/h2-5,10-11,15H,6-9,12-13H2,1H3,(H,27,28,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435427
PNG
(US10570116, Compound C35)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-27(2,15-22-28-21-9-4-3-8-20(21)25(33)29-22)16-23(31)30-12-10-17(11-13-30)24(32)18-6-5-7-19(14-18)26(34)35/h3-9,14,17H,10-13,15-16H2,1-2H3,(H,34,35)(H,28,29,33)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435413
PNG
(US10570116, Compound C21)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C24H30N6O4/c1-24(2,11-18-27-22-17(23(33)28-18)14-26-29(22)3)12-20(31)30-9-7-15(8-10-30)21(32)16-5-6-19(34-4)25-13-16/h5-6,13-15H,7-12H2,1-4H3,(H,27,28,33)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435427
PNG
(US10570116, Compound C35)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-27(2,15-22-28-21-9-4-3-8-20(21)25(33)29-22)16-23(31)30-12-10-17(11-13-30)24(32)18-6-5-7-19(14-18)26(34)35/h3-9,14,17H,10-13,15-16H2,1-2H3,(H,34,35)(H,28,29,33)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435394
PNG
(US10570116, Compound C5)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(c1)C(C)C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)30-15-19(14-26-30)24(32)18-8-10-29(11-9-18)23(31)13-17(3)12-22-27-21-7-5-4-6-20(21)25(33)28-22/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t17-/m1/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435432
PNG
(US10570116, Compound C40)
Show SMILES COC(=O)c1ccc(cc1C)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C30H35N3O5/c1-18-7-6-8-23-26(18)31-24(32-28(23)36)16-30(3,4)17-25(34)33-13-11-20(12-14-33)27(35)21-9-10-22(19(2)15-21)29(37)38-5/h6-10,15,20H,11-14,16-17H2,1-5H3,(H,31,32,36)
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n/an/a 4.70n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435407
PNG
(US10570116, Compound C15)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)CCC(C)(C)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H31N3O4/c1-27(2,26-28-22-7-5-4-6-21(22)25(33)29-26)15-12-23(31)30-16-13-19(14-17-30)24(32)18-8-10-20(34-3)11-9-18/h4-11,19H,12-17H2,1-3H3,(H,28,29,33)
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n/an/a 5n/an/an/an/an/an/a



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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435440
PNG
(US10570116, Compound C48)
Show SMILES CN(C)Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C29H36N4O3/c1-29(2,17-25-30-24-8-6-5-7-23(24)28(36)31-25)18-26(34)33-15-13-22(14-16-33)27(35)21-11-9-20(10-12-21)19-32(3)4/h5-12,22H,13-19H2,1-4H3,(H,30,31,36)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435415
PNG
(US10570116, Compound C23)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H25N3O5/c1-31-18-8-6-16(7-9-18)23(29)17-10-12-27(13-11-17)22(28)15-32-14-21-25-20-5-3-2-4-19(20)24(30)26-21/h2-9,17H,10-15H2,1H3,(H,25,26,30)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435418
PNG
(US10570116, Compound C26)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H23F2N3O5/c1-33-17-4-2-14(3-5-17)23(31)15-6-8-29(9-7-15)21(30)13-34-12-20-27-22-18(24(32)28-20)10-16(25)11-19(22)26/h2-5,10-11,15H,6-9,12-13H2,1H3,(H,27,28,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435400
PNG
(US10570116, Compound C9)
Show SMILES CC(C)[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)18(12-22-27-21-7-5-4-6-20(21)25(33)28-22)13-23(31)30-10-8-17(9-11-30)24(32)19-14-26-29(3)15-19/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t18-/m1/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435402
PNG
(US10570116, Compound C10)
Show SMILES CC(C)C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C26H33N5O3/c1-17(2)12-18(13-23-28-22-7-5-4-6-21(22)26(34)29-23)14-24(32)31-10-8-19(9-11-31)25(33)20-15-27-30(3)16-20/h4-7,15-19H,8-14H2,1-3H3,(H,28,29,34)/t18-/m0/s1
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435436
PNG
(US10570116, Compound C44)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-16(13-22-28-24-17(2)5-3-8-21(24)26(33)29-22)14-23(31)30-11-9-18(10-12-30)25(32)19-6-4-7-20(15-19)27(34)35/h3-8,15-16,18H,9-14H2,1-2H3,(H,34,35)(H,28,29,33)/t16-/m1/s1
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n/an/a 7.90n/an/an/an/an/an/a



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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435438
PNG
(US10570116, Compound C46)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C27H28FN3O5/c1-15(10-22-29-24-16(2)12-20(28)14-21(24)26(34)30-22)11-23(32)31-8-6-17(7-9-31)25(33)18-4-3-5-19(13-18)27(35)36/h3-5,12-15,17H,6-11H2,1-2H3,(H,35,36)(H,29,30,34)/t15-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435436
PNG
(US10570116, Compound C44)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-16(13-22-28-24-17(2)5-3-8-21(24)26(33)29-22)14-23(31)30-11-9-18(10-12-30)25(32)19-6-4-7-20(15-19)27(34)35/h3-8,15-16,18H,9-14H2,1-2H3,(H,34,35)(H,28,29,33)/t16-/m1/s1
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n/an/a 8.80n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435407
PNG
(US10570116, Compound C15)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)CCC(C)(C)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H31N3O4/c1-27(2,26-28-22-7-5-4-6-21(22)25(33)29-26)15-12-23(31)30-16-13-19(14-17-30)24(32)18-8-10-20(34-3)11-9-18/h4-11,19H,12-17H2,1-3H3,(H,28,29,33)
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n/an/a 9.20n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435417
PNG
(US10570116, Compound C25)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H24N4O5/c1-31-20-7-6-16(12-24-20)22(29)15-8-10-27(11-9-15)21(28)14-32-13-19-25-18-5-3-2-4-17(18)23(30)26-19/h2-7,12,15H,8-11,13-14H2,1H3,(H,25,26,30)
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n/an/a 12n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435394
PNG
(US10570116, Compound C5)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(c1)C(C)C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)30-15-19(14-26-30)24(32)18-8-10-29(11-9-18)23(31)13-17(3)12-22-27-21-7-5-4-6-20(21)25(33)28-22/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t17-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435416
PNG
(US10570116, Compound C24)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H23N5O4/c1-25-11-15(10-22-25)20(28)14-6-8-26(9-7-14)19(27)13-30-12-18-23-17-5-3-2-4-16(17)21(29)24-18/h2-5,10-11,14H,6-9,12-13H2,1H3,(H,23,24,29)
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n/an/a 12n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435420
PNG
(US10570116, Compound C28)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C23H22F2N4O5/c1-33-19-3-2-14(10-26-19)22(31)13-4-6-29(7-5-13)20(30)12-34-11-18-27-21-16(23(32)28-18)8-15(24)9-17(21)25/h2-3,8-10,13H,4-7,11-12H2,1H3,(H,27,28,32)
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n/an/a 12n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435419
PNG
(US10570116, Compound C27)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cccc2c(=O)[nH]1
Show InChI InChI=1S/C21H22FN5O4/c1-26-10-14(9-23-26)20(29)13-5-7-27(8-6-13)18(28)12-31-11-17-24-19-15(21(30)25-17)3-2-4-16(19)22/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,24,25,30)
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n/an/a 13n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435440
PNG
(US10570116, Compound C48)
Show SMILES CN(C)Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C29H36N4O3/c1-29(2,17-25-30-24-8-6-5-7-23(24)28(36)31-25)18-26(34)33-15-13-22(14-16-33)27(35)21-11-9-20(10-12-21)19-32(3)4/h5-12,22H,13-19H2,1-4H3,(H,30,31,36)
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n/an/a 14n/an/an/an/an/an/a



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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435400
PNG
(US10570116, Compound C9)
Show SMILES CC(C)[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)18(12-22-27-21-7-5-4-6-20(21)25(33)28-22)13-23(31)30-10-8-17(9-11-30)24(32)19-14-26-29(3)15-19/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t18-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435402
PNG
(US10570116, Compound C10)
Show SMILES CC(C)C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C26H33N5O3/c1-17(2)12-18(13-23-28-22-7-5-4-6-21(22)26(34)29-23)14-24(32)31-10-8-19(9-11-31)25(33)20-15-27-30(3)16-20/h4-7,15-19H,8-14H2,1-3H3,(H,28,29,34)/t18-/m0/s1
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435416
PNG
(US10570116, Compound C24)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H23N5O4/c1-25-11-15(10-22-25)20(28)14-6-8-26(9-7-14)19(27)13-30-12-18-23-17-5-3-2-4-16(17)21(29)24-18/h2-5,10-11,14H,6-9,12-13H2,1H3,(H,23,24,29)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435419
PNG
(US10570116, Compound C27)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cccc2c(=O)[nH]1
Show InChI InChI=1S/C21H22FN5O4/c1-26-10-14(9-23-26)20(29)13-5-7-27(8-6-13)18(28)12-31-11-17-24-19-15(21(30)25-17)3-2-4-16(19)22/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,24,25,30)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435395
PNG
(US10570116, Compound C6)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H28FN5O3/c1-14(8-20-27-22-15(2)10-18(25)11-19(22)24(33)28-20)9-21(31)30-6-4-16(5-7-30)23(32)17-12-26-29(3)13-17/h10-14,16H,4-9H2,1-3H3,(H,27,28,33)/t14-/m0/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435420
PNG
(US10570116, Compound C28)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C23H22F2N4O5/c1-33-19-3-2-14(10-26-19)22(31)13-4-6-29(7-5-13)20(30)12-34-11-18-27-21-16(23(32)28-18)8-15(24)9-17(21)25/h2-3,8-10,13H,4-7,11-12H2,1H3,(H,27,28,32)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435417
PNG
(US10570116, Compound C25)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H24N4O5/c1-31-20-7-6-16(12-24-20)22(29)15-8-10-27(11-9-15)21(28)14-32-13-19-25-18-5-3-2-4-17(18)23(30)26-19/h2-7,12,15H,8-11,13-14H2,1H3,(H,25,26,30)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435396
PNG
(US10570116, Compound C7)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H28FN5O3/c1-14(8-20-27-22-15(2)10-18(25)11-19(22)24(33)28-20)9-21(31)30-6-4-16(5-7-30)23(32)17-12-26-29(3)13-17/h10-14,16H,4-9H2,1-3H3,(H,27,28,33)/t14-/m1/s1
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435406
PNG
(US10570116, Compound C14)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CCC(C)(C)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,23-26-19-7-5-4-6-18(19)22(32)27-23)11-8-20(30)29-12-9-16(10-13-29)21(31)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435406
PNG
(US10570116, Compound C14)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CCC(C)(C)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,23-26-19-7-5-4-6-18(19)22(32)27-23)11-8-20(30)29-12-9-16(10-13-29)21(31)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,32)
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Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435439
PNG
(US10570116, Compound C47)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C27H28FN3O5/c1-15(10-22-29-24-16(2)12-20(28)14-21(24)26(34)30-22)11-23(32)31-8-6-17(7-9-31)25(33)18-4-3-5-19(13-18)27(35)36/h3-5,12-15,17H,6-11H2,1-2H3,(H,35,36)(H,29,30,34)/t15-/m0/s1
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435436
PNG
(US10570116, Compound C44)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-16(13-22-28-24-17(2)5-3-8-21(24)26(33)29-22)14-23(31)30-11-9-18(10-12-30)25(32)19-6-4-7-20(15-19)27(34)35/h3-8,15-16,18H,9-14H2,1-2H3,(H,34,35)(H,28,29,33)/t16-/m1/s1
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435437
PNG
(US10570116, Compound C45)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-16(13-22-28-24-17(2)5-3-8-21(24)26(33)29-22)14-23(31)30-11-9-18(10-12-30)25(32)19-6-4-7-20(15-19)27(34)35/h3-8,15-16,18H,9-14H2,1-2H3,(H,34,35)(H,28,29,33)/t16-/m0/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM435405
PNG
(US10570116, Compound C13)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)C(C)(C)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,11-8-20-26-19-7-5-4-6-18(19)22(31)27-20)23(32)29-12-9-16(10-13-29)21(30)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,31)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435420
PNG
(US10570116, Compound C28)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C23H22F2N4O5/c1-33-19-3-2-14(10-26-19)22(31)13-4-6-29(7-5-13)20(30)12-34-11-18-27-21-16(23(32)28-18)8-15(24)9-17(21)25/h2-3,8-10,13H,4-7,11-12H2,1H3,(H,27,28,32)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Tankyrase 1/2


(Homo sapiens (Human))
BDBM435405
PNG
(US10570116, Compound C13)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)C(C)(C)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,11-8-20-26-19-7-5-4-6-18(19)22(31)27-20)23(32)29-12-9-16(10-13-29)21(30)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,31)
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US Patent


Assay Description
TNKS 1 and 2: The activity ELISA is performed in 384 well Glutathione coated microtiter plates (Express capture Glutathione coated plate, Biocat, Hei...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435435
PNG
(US10570116, Compound C43)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)C[C@@H](C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-17(14-23-29-25-18(2)6-4-9-22(25)27(34)30-23)15-24(32)31-12-10-19(11-13-31)26(33)20-7-5-8-21(16-20)28(35)36-3/h4-9,16-17,19H,10-15H2,1-3H3,(H,29,30,34)/t17-/m0/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435421
PNG
(US10570116, Compound C29)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)NCCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H26N4O4/c1-32-18-8-6-16(7-9-18)22(29)17-11-14-28(15-12-17)24(31)25-13-10-21-26-20-5-3-2-4-19(20)23(30)27-21/h2-9,17H,10-15H2,1H3,(H,25,31)(H,26,27,30)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435415
PNG
(US10570116, Compound C23)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H25N3O5/c1-31-18-8-6-16(7-9-18)23(29)17-10-12-27(13-11-17)22(28)15-32-14-21-25-20-5-3-2-4-19(20)24(30)26-21/h2-9,17H,10-15H2,1H3,(H,25,26,30)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435418
PNG
(US10570116, Compound C26)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H23F2N3O5/c1-33-17-4-2-14(3-5-17)23(31)15-6-8-29(9-7-15)21(30)13-34-12-20-27-22-18(24(32)28-20)10-16(25)11-19(22)26/h2-5,10-11,15H,6-9,12-13H2,1H3,(H,27,28,32)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435443
PNG
(US10570116, Compound C51)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H28N4O3/c1-16(11-20-13-18-5-3-4-6-21(18)24(31)26-20)12-22(29)28-9-7-17(8-10-28)23(30)19-14-25-27(2)15-19/h3-6,13-17H,7-12H2,1-2H3,(H,26,31)/t16-/m1/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435444
PNG
(US10570116, Compound C52)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C(O)=O)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H30N2O5/c1-28(2,16-22-15-21-5-3-4-6-23(21)26(33)29-22)17-24(31)30-13-11-19(12-14-30)25(32)18-7-9-20(10-8-18)27(34)35/h3-10,15,19H,11-14,16-17H2,1-2H3,(H,29,33)(H,34,35)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435434
PNG
(US10570116, Compound C42)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)C[C@H](C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C28H31N3O5/c1-17(14-23-29-25-18(2)6-4-9-22(25)27(34)30-23)15-24(32)31-12-10-19(11-13-31)26(33)20-7-5-8-21(16-20)28(35)36-3/h4-9,16-17,19H,10-15H2,1-3H3,(H,29,30,34)/t17-/m1/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435429
PNG
(US10570116, Compound C37)
Show SMILES Cc1cccc2c1nc(CC(C)(C)CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)[nH]c2=O
Show InChI InChI=1S/C28H31N3O5/c1-17-6-4-9-21-24(17)29-22(30-26(21)34)15-28(2,3)16-23(32)31-12-10-18(11-13-31)25(33)19-7-5-8-20(14-19)27(35)36/h4-9,14,18H,10-13,15-16H2,1-3H3,(H,35,36)(H,29,30,34)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435417
PNG
(US10570116, Compound C25)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H24N4O5/c1-31-20-7-6-16(12-24-20)22(29)15-8-10-27(11-9-15)21(28)14-32-13-19-25-18-5-3-2-4-17(18)23(30)26-19/h2-7,12,15H,8-11,13-14H2,1H3,(H,25,26,30)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435386
PNG
(US10570116, Compound C2)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H27N5O3/c1-15(11-20-25-19-6-4-3-5-18(19)23(31)26-20)12-21(29)28-9-7-16(8-10-28)22(30)17-13-24-27(2)14-17/h3-6,13-16H,7-12H2,1-2H3,(H,25,26,31)/t15-/m0/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435393
PNG
(US10570116, Compound C4)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(c1)C(C)C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)30-15-19(14-26-30)24(32)18-8-10-29(11-9-18)23(31)13-17(3)12-22-27-21-7-5-4-6-20(21)25(33)28-22/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t17-/m0/s1
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435422
PNG
(US10570116, Compound C30)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)N(C)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H28N4O4/c1-28(14-13-22-26-21-6-4-3-5-20(21)24(31)27-22)25(32)29-15-11-18(12-16-29)23(30)17-7-9-19(33-2)10-8-17/h3-10,18H,11-16H2,1-2H3,(H,26,27,31)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435442
PNG
(US10570116, Compound C50)
Show SMILES C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H28N4O3/c1-16(11-20-13-18-5-3-4-6-21(18)24(31)26-20)12-22(29)28-9-7-17(8-10-28)23(30)19-14-25-27(2)15-19/h3-6,13-17H,7-12H2,1-2H3,(H,26,31)/t16-/m0/s1
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435432
PNG
(US10570116, Compound C40)
Show SMILES COC(=O)c1ccc(cc1C)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C30H35N3O5/c1-18-7-6-8-23-26(18)31-24(32-28(23)36)16-30(3,4)17-25(34)33-13-11-20(12-14-33)27(35)21-9-10-22(19(2)15-21)29(37)38-5/h6-10,15,20H,11-14,16-17H2,1-5H3,(H,31,32,36)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435394
PNG
(US10570116, Compound C5)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(c1)C(C)C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)30-15-19(14-26-30)24(32)18-8-10-29(11-9-18)23(31)13-17(3)12-22-27-21-7-5-4-6-20(21)25(33)28-22/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t17-/m1/s1
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435419
PNG
(US10570116, Compound C27)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2c(F)cccc2c(=O)[nH]1
Show InChI InChI=1S/C21H22FN5O4/c1-26-10-14(9-23-26)20(29)13-5-7-27(8-6-13)18(28)12-31-11-17-24-19-15(21(30)25-17)3-2-4-16(19)22/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,24,25,30)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435441
PNG
(US10570116, Compound C49)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H30N4O3/c1-25(2,13-20-12-18-6-4-5-7-21(18)24(32)27-20)14-22(30)29-10-8-17(9-11-29)23(31)19-15-26-28(3)16-19/h4-7,12,15-17H,8-11,13-14H2,1-3H3,(H,27,32)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435433
PNG
(US10570116, Compound C41)
Show SMILES Cc1cc(ccc1C(O)=O)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C29H33N3O5/c1-17-6-5-7-22-25(17)30-23(31-27(22)35)15-29(3,4)16-24(33)32-12-10-19(11-13-32)26(34)20-8-9-21(28(36)37)18(2)14-20/h5-9,14,19H,10-13,15-16H2,1-4H3,(H,36,37)(H,30,31,35)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435416
PNG
(US10570116, Compound C24)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)COCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H23N5O4/c1-25-11-15(10-22-25)20(28)14-6-8-26(9-7-14)19(27)13-30-12-18-23-17-5-3-2-4-16(17)21(29)24-18/h2-5,10-11,14H,6-9,12-13H2,1H3,(H,23,24,29)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435407
PNG
(US10570116, Compound C15)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)CCC(C)(C)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H31N3O4/c1-27(2,26-28-22-7-5-4-6-21(22)25(33)29-26)15-12-23(31)30-16-13-19(14-17-30)24(32)18-8-10-20(34-3)11-9-18/h4-11,19H,12-17H2,1-3H3,(H,28,29,33)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435423
PNG
(US10570116, Compound C31)
Show SMILES CN(CCc1nc2ccccc2c(=O)[nH]1)C(=O)N1CCC(CC1)C(=O)c1cnn(C)c1
Show InChI InChI=1S/C22H26N6O3/c1-26(10-9-19-24-18-6-4-3-5-17(18)21(30)25-19)22(31)28-11-7-15(8-12-28)20(29)16-13-23-27(2)14-16/h3-6,13-15H,7-12H2,1-2H3,(H,24,25,30)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435404
PNG
(US10570116, Compound C12)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC1(Cc2nc3ccccc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C24H27N5O3/c1-28-15-17(14-25-28)22(31)16-6-10-29(11-7-16)21(30)13-24(8-9-24)12-20-26-19-5-3-2-4-18(19)23(32)27-20/h2-5,14-16H,6-13H2,1H3,(H,26,27,32)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435428
PNG
(US10570116, Compound C36)
Show SMILES COC(=O)c1cccc(c1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C29H33N3O5/c1-18-7-5-10-22-25(18)30-23(31-27(22)35)16-29(2,3)17-24(33)32-13-11-19(12-14-32)26(34)20-8-6-9-21(15-20)28(36)37-4/h5-10,15,19H,11-14,16-17H2,1-4H3,(H,30,31,35)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435411
PNG
(US10570116, Compound C19)
Show SMILES CC(C)n1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C25H34N6O3/c1-16(2)31-15-18(14-26-31)22(33)17-6-10-30(11-7-17)21(32)13-25(3,4)12-20-27-23-19(24(34)28-20)8-9-29(23)5/h8-9,14-17H,6-7,10-13H2,1-5H3,(H,27,28,34)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435408
PNG
(US10570116, Compound C16)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O4/c1-25(2,13-19-27-23-18(24(33)28-19)9-10-29(23)3)14-21(31)30-11-7-16(8-12-30)22(32)17-5-6-20(34-4)26-15-17/h5-6,9-10,15-16H,7-8,11-14H2,1-4H3,(H,27,28,33)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435445
PNG
(US10570116, Compound C53)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1cc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C28H30N2O5/c1-28(2,16-22-15-19-6-3-4-9-23(19)26(33)29-22)17-24(31)30-12-10-18(11-13-30)25(32)20-7-5-8-21(14-20)27(34)35/h3-9,14-15,18H,10-13,16-17H2,1-2H3,(H,29,33)(H,34,35)
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n/an/a 9.20E+3n/an/an/an/an/an/a



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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435405
PNG
(US10570116, Compound C13)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)C(C)(C)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,11-8-20-26-19-7-5-4-6-18(19)22(31)27-20)23(32)29-12-9-16(10-13-29)21(30)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,31)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435384
PNG
(US10570116, Compound C1)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,12-20-26-19-7-5-4-6-18(19)23(32)27-20)13-21(30)29-10-8-16(9-11-29)22(31)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,32)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435406
PNG
(US10570116, Compound C14)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CCC(C)(C)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C24H29N5O3/c1-24(2,23-26-19-7-5-4-6-18(19)22(32)27-23)11-8-20(30)29-12-9-16(10-13-29)21(31)17-14-25-28(3)15-17/h4-7,14-16H,8-13H2,1-3H3,(H,26,27,32)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435403
PNG
(US10570116, Compound C11)
Show SMILES CC(C)C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C26H33N5O3/c1-17(2)12-18(13-23-28-22-7-5-4-6-21(22)26(34)29-23)14-24(32)31-10-8-19(9-11-31)25(33)20-15-27-30(3)16-20/h4-7,15-19H,8-14H2,1-3H3,(H,28,29,34)/t18-/m1/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435390
PNG
(US10570116, Compound C3)
Show SMILES C[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H27N5O3/c1-15(11-20-25-19-6-4-3-5-18(19)23(31)26-20)12-21(29)28-9-7-16(8-10-28)22(30)17-13-24-27(2)14-17/h3-6,13-16H,7-12H2,1-2H3,(H,25,26,31)/t15-/m1/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435425
PNG
(US10570116, Compound C33)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C(O)=O)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-27(2,15-22-28-21-6-4-3-5-20(21)25(33)29-22)16-23(31)30-13-11-18(12-14-30)24(32)17-7-9-19(10-8-17)26(34)35/h3-10,18H,11-16H2,1-2H3,(H,34,35)(H,28,29,33)
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n/an/a 1.70E+4n/an/an/an/an/an/a



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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435399
PNG
(US10570116, Compound C8)
Show SMILES CC(C)[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)18(12-22-27-21-7-5-4-6-20(21)25(33)28-22)13-23(31)30-10-8-17(9-11-30)24(32)19-14-26-29(3)15-19/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t18-/m0/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435402
PNG
(US10570116, Compound C10)
Show SMILES CC(C)C[C@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C26H33N5O3/c1-17(2)12-18(13-23-28-22-7-5-4-6-21(22)26(34)29-23)14-24(32)31-10-8-19(9-11-31)25(33)20-15-27-30(3)16-20/h4-7,15-19H,8-14H2,1-3H3,(H,28,29,34)/t18-/m0/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435427
PNG
(US10570116, Compound C35)
Show SMILES CC(C)(CC(=O)N1CCC(CC1)C(=O)c1cccc(c1)C(O)=O)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C27H29N3O5/c1-27(2,15-22-28-21-9-4-3-8-20(21)25(33)29-22)16-23(31)30-12-10-17(11-13-30)24(32)18-6-5-7-19(14-18)26(34)35/h3-9,14,17H,10-13,15-16H2,1-2H3,(H,34,35)(H,28,29,33)
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n/an/a 2.90E+4n/an/an/an/an/an/a



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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435413
PNG
(US10570116, Compound C21)
Show SMILES COc1ccc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C24H30N6O4/c1-24(2,11-18-27-22-17(23(33)28-18)14-26-29(22)3)12-20(31)30-9-7-15(8-10-30)21(32)16-5-6-19(34-4)25-13-16/h5-6,13-15H,7-12H2,1-4H3,(H,27,28,33)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435400
PNG
(US10570116, Compound C9)
Show SMILES CC(C)[C@@H](CC(=O)N1CCC(CC1)C(=O)c1cnn(C)c1)Cc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O3/c1-16(2)18(12-22-27-21-7-5-4-6-20(21)25(33)28-22)13-23(31)30-10-8-17(9-11-30)24(32)19-14-26-29(3)15-19/h4-7,14-18H,8-13H2,1-3H3,(H,27,28,33)/t18-/m1/s1
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435410
PNG
(US10570116, Compound C18)
Show SMILES CCn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C24H32N6O3/c1-5-30-15-17(14-25-30)21(32)16-6-10-29(11-7-16)20(31)13-24(2,3)12-19-26-22-18(23(33)27-19)8-9-28(22)4/h8-9,14-16H,5-7,10-13H2,1-4H3,(H,26,27,33)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435414
PNG
(US10570116, Compound C22)
Show SMILES COc1ncc(cc1C)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C25H32N6O4/c1-15-10-17(13-26-24(15)35-5)21(33)16-6-8-31(9-7-16)20(32)12-25(2,3)11-19-28-22-18(23(34)29-19)14-27-30(22)4/h10,13-14,16H,6-9,11-12H2,1-5H3,(H,28,29,34)
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US Patent


Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435409
PNG
(US10570116, Compound C17)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ccc2c(=O)[nH]1
Show InChI InChI=1S/C23H30N6O3/c1-23(2,11-18-25-21-17(22(32)26-18)7-8-27(21)3)12-19(30)29-9-5-15(6-10-29)20(31)16-13-24-28(4)14-16/h7-8,13-15H,5-6,9-12H2,1-4H3,(H,25,26,32)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM435412
PNG
(US10570116, Compound C20)
Show SMILES Cn1cc(cn1)C(=O)C1CCN(CC1)C(=O)CC(C)(C)Cc1nc2n(C)ncc2c(=O)[nH]1
Show InChI InChI=1S/C22H29N7O3/c1-22(2,9-17-25-20-16(21(32)26-17)12-24-28(20)4)10-18(30)29-7-5-14(6-8-29)19(31)15-11-23-27(3)13-15/h11-14H,5-10H2,1-4H3,(H,25,26,32)
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Assay Description
PARP-1: The autoparsylation assay is performed as 384-well HTRF® (Cisbio, Codolet, France) assay format in Greiner low volume nb 384-well microtiter ...


US Patent US10570116 (2020)


BindingDB Entry DOI: 10.7270/Q2J968R4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%