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Patent code US10570118

Compile Data Set for Download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435486
PNG
(US10570118, Example 40)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(cc2cc(cc(F)c2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C31H29FN4O4/c1-3-28(38)35-14-21(15-35)26-11-19-9-18(17-7-8-17)10-24(32)29(19)31(40)36(26)25-6-4-5-22(23(25)16-37)20-12-27(30(33)39)34(2)13-20/h3-6,9-13,17,21,37H,1,7-8,14-16H2,2H3,(H2,33,39)
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n/an/a 0.420n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435467
PNG
(US10570118, Example 21)
Show SMILES Nc1cc(ncn1)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C29H27N5O3/c1-2-28(36)33-13-20(14-33)26-11-19-10-18(17-6-7-17)8-9-21(19)29(37)34(26)25-5-3-4-22(23(25)15-35)24-12-27(30)32-16-31-24/h2-5,8-12,16-17,20,35H,1,6-7,13-15H2,(H2,30,31,32)
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n/an/a 0.480n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435452
PNG
(US10570118, Example 42 | US10570118, Example 43 | ...)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C31H30N4O4/c1-3-29(37)34-15-22(16-34)27-12-20-11-19(18-7-8-18)9-10-24(20)31(39)35(27)26-6-4-5-23(25(26)17-36)21-13-28(30(32)38)33(2)14-21/h3-6,9-14,18,22,36H,1,7-8,15-17H2,2H3,(H2,32,38)
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n/an/a 0.560n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435446
PNG
(US10570118, Example 1)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C#N
Show InChI InChI=1S/C29H27N5O3/c1-32-12-20(11-27(32)28(31)36)22-3-2-4-25(24(22)15-35)34-26(21-13-33(14-21)16-30)10-19-9-18(17-5-6-17)7-8-23(19)29(34)37/h2-4,7-12,17,21,35H,5-6,13-15H2,1H3,(H2,31,36)
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435452
PNG
(US10570118, Example 42 | US10570118, Example 43 | ...)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C31H30N4O4/c1-3-29(37)34-15-22(16-34)27-12-20-11-19(18-7-8-18)9-10-24(20)31(39)35(27)26-6-4-5-23(25(26)17-36)21-13-28(30(32)38)33(2)14-21/h3-6,9-14,18,22,36H,1,7-8,15-17H2,2H3,(H2,32,38)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435487
PNG
(US10570118, Example 41)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(CC2CN(C2)C(=O)C=C)cc2cc(cc(F)c2c1=O)C1CC1
Show InChI InChI=1S/C32H31FN4O4/c1-3-29(39)36-14-18(15-36)9-23-11-21-10-20(19-7-8-19)12-26(33)30(21)32(41)37(23)27-6-4-5-24(25(27)17-38)22-13-28(31(34)40)35(2)16-22/h3-6,10-13,16,18-19,38H,1,7-9,14-15,17H2,2H3,(H2,34,40)
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n/an/a 0.710n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435463
PNG
(US10570118, Example 17)
Show SMILES Nc1cc(ccn1)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C30H28N4O3/c1-2-29(36)33-15-22(16-33)27-13-21-12-19(18-6-7-18)8-9-24(21)30(37)34(27)26-5-3-4-23(25(26)17-35)20-10-11-32-28(31)14-20/h2-5,8-14,18,22,35H,1,6-7,15-17H2,(H2,31,32)
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n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435448
PNG
(US10570118, Example 3)
Show SMILES OCc1c(cccc1-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C#N)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C30H25N5O2/c31-17-34-14-23(15-34)29-12-21-10-19(18-4-5-18)6-8-25(21)30(37)35(29)28-3-1-2-24(26(28)16-36)20-7-9-27-22(11-20)13-32-33-27/h1-3,6-13,18,23,36H,4-5,14-16H2,(H,32,33)
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n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435456
PNG
(US10570118, Example 11)
Show SMILES Cn1cc(cc(N)c1=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C31H30N4O4/c1-3-29(37)34-15-22(16-34)28-13-20-11-19(18-7-8-18)9-10-24(20)30(38)35(28)27-6-4-5-23(25(27)17-36)21-12-26(32)31(39)33(2)14-21/h3-6,9-14,18,22,36H,1,7-8,15-17,32H2,2H3
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n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435458
PNG
(US10570118, Example 13)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C32H32N4O4/c1-3-30(38)35-12-11-21(17-35)28-14-22-13-20(19-7-8-19)9-10-25(22)32(40)36(28)27-6-4-5-24(26(27)18-37)23-15-29(31(33)39)34(2)16-23/h3-6,9-10,13-16,19,21,37H,1,7-8,11-12,17-18H2,2H3,(H2,33,39)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435454
PNG
(US10570118, Example 9)
Show SMILES Cn1cc(cc(N)c1=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C#N
Show InChI InChI=1S/C29H27N5O3/c1-32-12-20(10-25(31)29(32)37)22-3-2-4-26(24(22)15-35)34-27(21-13-33(14-21)16-30)11-19-9-18(17-5-6-17)7-8-23(19)28(34)36/h2-4,7-12,17,21,35H,5-6,13-15,31H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435455
PNG
(US10570118, Example 10)
Show SMILES Cc1ccc2c(c1)cc(C1CN(C1)C(=O)C=C)n(-c1cccc(-c3ccc4[nH]ncc4c3)c1CO)c2=O
Show InChI InChI=1S/C30H26N4O3/c1-3-29(36)33-15-22(16-33)28-13-20-11-18(2)7-9-24(20)30(37)34(28)27-6-4-5-23(25(27)17-35)19-8-10-26-21(12-19)14-31-32-26/h3-14,22,35H,1,15-17H2,2H3,(H,31,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435457
PNG
(US10570118, Example 12)
Show SMILES Nc1cc(ncn1)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C#N
Show InChI InChI=1S/C27H24N6O2/c28-14-32-11-19(12-32)25-9-18-8-17(16-4-5-16)6-7-20(18)27(35)33(25)24-3-1-2-21(22(24)13-34)23-10-26(29)31-15-30-23/h1-3,6-10,15-16,19,34H,4-5,11-13H2,(H2,29,30,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435451
PNG
(US10570118, Example 6)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(CC2CCN2C(=O)C=C)cc2cc(ccc2c1=O)C1CC1
Show InChI InChI=1S/C32H32N4O4/c1-3-30(38)35-12-11-23(35)16-24-14-21-13-20(19-7-8-19)9-10-26(21)32(40)36(24)28-6-4-5-25(27(28)18-37)22-15-29(31(33)39)34(2)17-22/h3-6,9-10,13-15,17,19,23,37H,1,7-8,11-12,16,18H2,2H3,(H2,33,39)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435447
PNG
(US10570118, Example 2)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(CC2CN(C2)C(=O)C=C)cc2cc(ccc2c1=O)C1CC1
Show InChI InChI=1S/C32H32N4O4/c1-3-30(38)35-15-19(16-35)11-24-13-22-12-21(20-7-8-20)9-10-26(22)32(40)36(24)28-6-4-5-25(27(28)18-37)23-14-29(31(33)39)34(2)17-23/h3-6,9-10,12-14,17,19-20,37H,1,7-8,11,15-16,18H2,2H3,(H2,33,39)
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n/an/a 4n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435460
PNG
(US10570118, Example 15)
Show SMILES CNc1cc(ccn1)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C31H30N4O3/c1-3-30(37)34-16-23(17-34)28-14-22-13-20(19-7-8-19)9-10-25(22)31(38)35(28)27-6-4-5-24(26(27)18-36)21-11-12-33-29(15-21)32-2/h3-6,9-15,19,23,36H,1,7-8,16-18H2,2H3,(H,32,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435449
PNG
(US10570118, Example 4)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C#N
Show InChI InChI=1S/C30H26N4O3/c31-17-33-14-23(15-33)28-13-22-11-19(18-7-8-18)9-10-25(22)30(37)34(28)27-6-2-5-24(26(27)16-35)20-3-1-4-21(12-20)29(32)36/h1-6,9-13,18,23,35H,7-8,14-16H2,(H2,32,36)
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435450
PNG
(US10570118, Example 5)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C32H29N3O4/c1-2-30(37)34-16-24(17-34)29-15-23-13-20(19-9-10-19)11-12-26(23)32(39)35(29)28-8-4-7-25(27(28)18-36)21-5-3-6-22(14-21)31(33)38/h2-8,11-15,19,24,36H,1,9-10,16-18H2,(H2,33,38)
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n/an/a 5.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435466
PNG
(US10570118, Example 20)
Show SMILES Nc1cc(ccn1)-c1cccc(c1Cl)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C29H25ClN4O2/c1-2-27(35)33-15-21(16-33)25-13-20-12-18(17-6-7-17)8-9-23(20)29(36)34(25)24-5-3-4-22(28(24)30)19-10-11-32-26(31)14-19/h2-5,8-14,17,21H,1,6-7,15-16H2,(H2,31,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435453
PNG
(US10570118, Example 8)
Show SMILES CC#CC(=O)N1CC(Cc2cc3cc(ccc3c(=O)n2-c2cccc(-c3cc(C(N)=O)n(C)c3)c2CO)C2CC2)C1
Show InChI InChI=1S/C33H32N4O4/c1-3-5-31(39)36-16-20(17-36)12-25-14-23-13-22(21-8-9-21)10-11-27(23)33(41)37(25)29-7-4-6-26(28(29)19-38)24-15-30(32(34)40)35(2)18-24/h4,6-7,10-11,13-15,18,20-21,38H,8-9,12,16-17,19H2,1-2H3,(H2,34,40)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435459
PNG
(US10570118, Example 14)
Show SMILES Nc1cc(ncn1)-c1cccc(c1CO)-n1c(CC2CN(C2)C(=O)C=C)cc2cc(ccc2c1=O)C1CC1
Show InChI InChI=1S/C30H29N5O3/c1-2-29(37)34-14-18(15-34)10-22-12-21-11-20(19-6-7-19)8-9-23(21)30(38)35(22)27-5-3-4-24(25(27)16-36)26-13-28(31)33-17-32-26/h2-5,8-9,11-13,17-19,36H,1,6-7,10,14-16H2,(H2,31,32,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435461
PNG
(US10570118, Example 16)
Show SMILES Cn1cc(cc(N)c1=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C32H32N4O4/c1-3-30(38)35-12-11-21(17-35)29-15-22-13-20(19-7-8-19)9-10-25(22)31(39)36(29)28-6-4-5-24(26(28)18-37)23-14-27(33)32(40)34(2)16-23/h3-6,9-10,13-16,19,21,37H,1,7-8,11-12,17-18,33H2,2H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435468
PNG
(US10570118, Example 22)
Show SMILES OCc1c(cccc1-n1c(cc2cc(ccc2c1=O)C1CC1)C1CCN(C1)C(=O)C=C)-c1ccncc1
Show InChI InChI=1S/C31H29N3O3/c1-2-30(36)33-15-12-23(18-33)29-17-24-16-22(20-6-7-20)8-9-26(24)31(37)34(29)28-5-3-4-25(27(28)19-35)21-10-13-32-14-11-21/h2-5,8-11,13-14,16-17,20,23,35H,1,6-7,12,15,18-19H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435464
PNG
(US10570118, Example 18)
Show SMILES CN(Cc1cc2cc(ccc2c(=O)n1-c1cccc(-c2cc(C(N)=O)n(C)c2)c1CO)C1CC1)C(=O)C=C
Show InChI InChI=1S/C30H30N4O4/c1-4-28(36)33(3)16-22-13-20-12-19(18-8-9-18)10-11-24(20)30(38)34(22)26-7-5-6-23(25(26)17-35)21-14-27(29(31)37)32(2)15-21/h4-7,10-15,18,35H,1,8-9,16-17H2,2-3H3,(H2,31,37)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435465
PNG
(US10570118, Example 19)
Show SMILES CC#CC(=O)N1CC(C1)c1cc2cc(ccc2c(=O)n1-c1cccc(-c2cc(C(N)=O)n(C)c2)c1CO)C1CC1
Show InChI InChI=1S/C32H30N4O4/c1-3-5-30(38)35-16-23(17-35)28-13-21-12-20(19-8-9-19)10-11-25(21)32(40)36(28)27-7-4-6-24(26(27)18-37)22-14-29(31(33)39)34(2)15-22/h4,6-7,10-15,19,23,37H,8-9,16-18H2,1-2H3,(H2,33,39)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435484
PNG
(US10570118, Example 38 | US10570118, Example 39)
Show SMILES COc1cc(cc2cc(CC3CN(C3)C(=O)C=C)n(-c3cccc(-c4cc(C(N)=O)n(C)c4)c3CO)c(=O)c12)C1CC1
Show InChI InChI=1S/C33H34N4O5/c1-4-30(39)36-15-19(16-36)10-24-12-22-11-21(20-8-9-20)14-29(42-3)31(22)33(41)37(24)27-7-5-6-25(26(27)18-38)23-13-28(32(34)40)35(2)17-23/h4-7,11-14,17,19-20,38H,1,8-10,15-16,18H2,2-3H3,(H2,34,40)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435469
PNG
(US10570118, Example 23)
Show SMILES CN(Cc1cc2cc(ccc2c(=O)n1-c1cccc(-c2ccnc(N)c2)c1CO)C1CC1)C(=O)C=C
Show InChI InChI=1S/C29H28N4O3/c1-3-28(35)32(2)16-22-14-21-13-19(18-7-8-18)9-10-24(21)29(36)33(22)26-6-4-5-23(25(26)17-34)20-11-12-31-27(30)15-20/h3-6,9-15,18,34H,1,7-8,16-17H2,2H3,(H2,30,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435470
PNG
(US10570118, Example 24)
Show SMILES CN(Cc1cc2cc(ccc2c(=O)n1-c1cccc(c1CO)-c1cc(N)c(=O)n(C)c1)C1CC1)C(=O)C=C
Show InChI InChI=1S/C30H30N4O4/c1-4-28(36)32(2)16-22-13-20-12-19(18-8-9-18)10-11-24(20)29(37)34(22)27-7-5-6-23(25(27)17-35)21-14-26(31)30(38)33(3)15-21/h4-7,10-15,18,35H,1,8-9,16-17,31H2,2-3H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435471
PNG
(US10570118, Example 25)
Show SMILES OCc1c(cccc1-n1c(cc2cc(ccc2c1=O)C1CC1)C1CCN(C1)C(=O)C=C)-c1ccn2cncc2c1
Show InChI InChI=1S/C33H30N4O3/c1-2-32(39)35-12-11-24(18-35)31-16-25-14-22(21-6-7-21)8-9-28(25)33(40)37(31)30-5-3-4-27(29(30)19-38)23-10-13-36-20-34-17-26(36)15-23/h2-5,8-10,13-17,20-21,24,38H,1,6-7,11-12,18-19H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435472
PNG
(US10570118, Example 26)
Show SMILES C\C=C\C(=O)N1CC(C1)c1cc2cc(ccc2c(=O)n1-c1cccc(-c2cc(C(N)=O)n(C)c2)c1CO)C1CC1
Show InChI InChI=1S/C32H32N4O4/c1-3-5-30(38)35-16-23(17-35)28-13-21-12-20(19-8-9-19)10-11-25(21)32(40)36(28)27-7-4-6-24(26(27)18-37)22-14-29(31(33)39)34(2)15-22/h3-7,10-15,19,23,37H,8-9,16-18H2,1-2H3,(H2,33,39)/b5-3+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435484
PNG
(US10570118, Example 38 | US10570118, Example 39)
Show SMILES COc1cc(cc2cc(CC3CN(C3)C(=O)C=C)n(-c3cccc(-c4cc(C(N)=O)n(C)c4)c3CO)c(=O)c12)C1CC1
Show InChI InChI=1S/C33H34N4O5/c1-4-30(39)36-15-19(16-36)10-24-12-22-11-21(20-8-9-20)14-29(42-3)31(22)33(41)37(24)27-7-5-6-25(26(27)18-38)23-13-28(32(34)40)35(2)17-23/h4-7,11-14,17,19-20,38H,1,8-10,15-16,18H2,2-3H3,(H2,34,40)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435473
PNG
(US10570118, Example 27)
Show SMILES OCc1c(cccc1-n1c(CC2CN(C2)C(=O)C=C)cc2cc(ccc2c1=O)C1CC1)-c1ccc2cncn2c1
Show InChI InChI=1S/C33H30N4O3/c1-2-32(39)35-16-21(17-35)12-27-14-25-13-23(22-6-7-22)9-11-29(25)33(40)37(27)31-5-3-4-28(30(31)19-38)24-8-10-26-15-34-20-36(26)18-24/h2-5,8-11,13-15,18,20-22,38H,1,6-7,12,16-17,19H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435474
PNG
(US10570118, Example 28)
Show SMILES CC#CC(=O)N1CC(C1)c1cc2cc(ccc2c(=O)n1-c1cccc(-c2cc(N)c(=O)n(C)c2)c1CO)C1CC1
Show InChI InChI=1S/C32H30N4O4/c1-3-5-30(38)35-16-23(17-35)29-14-21-12-20(19-8-9-19)10-11-25(21)31(39)36(29)28-7-4-6-24(26(28)18-37)22-13-27(33)32(40)34(2)15-22/h4,6-7,10-15,19,23,37H,8-9,16-18,33H2,1-2H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435475
PNG
(US10570118, Example 29)
Show SMILES CNc1cc(ccn1)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)\C=C\C
Show InChI InChI=1S/C32H32N4O3/c1-3-5-31(38)35-17-24(18-35)29-15-23-14-21(20-8-9-20)10-11-26(23)32(39)36(29)28-7-4-6-25(27(28)19-37)22-12-13-34-30(16-22)33-2/h3-7,10-16,20,24,37H,8-9,17-19H2,1-2H3,(H,33,34)/b5-3+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435476
PNG
(US10570118, Example 30)
Show SMILES CC#CC(=O)N1CC(C1)c1cc2cc(ccc2c(=O)n1-c1cccc(-c2ccc3[nH]ncc3c2)c1CO)C1CC1
Show InChI InChI=1S/C33H28N4O3/c1-2-4-32(39)36-17-25(18-36)31-15-23-13-21(20-7-8-20)9-11-27(23)33(40)37(31)30-6-3-5-26(28(30)19-38)22-10-12-29-24(14-22)16-34-35-29/h3,5-6,9-16,20,25,38H,7-8,17-19H2,1H3,(H,34,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435477
PNG
(US10570118, Example 31)
Show SMILES Cn1cc(cc(N)c1=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CCN(C1)C#N
Show InChI InChI=1S/C30H29N5O3/c1-33-14-22(12-26(32)30(33)38)23-3-2-4-27(25(23)16-36)35-28(20-9-10-34(15-20)17-31)13-21-11-19(18-5-6-18)7-8-24(21)29(35)37/h2-4,7-8,11-14,18,20,36H,5-6,9-10,15-16,32H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435478
PNG
(US10570118, Example 32)
Show SMILES CN(Cc1cc2cc(ccc2c(=O)n1-c1cccc(-c2cc(N)c(=O)n(C)c2)c1CO)C1CC1)C#N
Show InChI InChI=1S/C28H27N5O3/c1-31(16-29)14-21-11-19-10-18(17-6-7-17)8-9-23(19)27(35)33(21)26-5-3-4-22(24(26)15-34)20-12-25(30)28(36)32(2)13-20/h3-5,8-13,17,34H,6-7,14-15,30H2,1-2H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435479
PNG
(US10570118, Example 33)
Show SMILES CNc1cc(ccn1)-c1cccc(c1CO)-n1c(CC2CN(C2)C(=O)C=C)cc2cc(ccc2c1=O)C1CC1
Show InChI InChI=1S/C32H32N4O3/c1-3-31(38)35-17-20(18-35)13-25-15-24-14-22(21-7-8-21)9-10-27(24)32(39)36(25)29-6-4-5-26(28(29)19-37)23-11-12-34-30(16-23)33-2/h3-6,9-12,14-16,20-21,37H,1,7-8,13,17-19H2,2H3,(H,33,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435481
PNG
(US10570118, Example 35)
Show SMILES CNc1cc(ccn1)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C#CC
Show InChI InChI=1S/C32H30N4O3/c1-3-5-31(38)35-17-24(18-35)29-15-23-14-21(20-8-9-20)10-11-26(23)32(39)36(29)28-7-4-6-25(27(28)19-37)22-12-13-34-30(16-22)33-2/h4,6-7,10-16,20,24,37H,8-9,17-19H2,1-2H3,(H,33,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435480
PNG
(US10570118, Example 34)
Show SMILES CC#CC(=O)N(C)Cc1cc2cc(ccc2c(=O)n1-c1cccc(-c2cc(C(N)=O)n(C)c2)c1CO)C1CC1
Show InChI InChI=1S/C31H30N4O4/c1-4-6-29(37)34(3)17-23-14-21-13-20(19-9-10-19)11-12-25(21)31(39)35(23)27-8-5-7-24(26(27)18-36)22-15-28(30(32)38)33(2)16-22/h5,7-8,11-16,19,36H,9-10,17-18H2,1-3H3,(H2,32,38)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435452
PNG
(US10570118, Example 42 | US10570118, Example 43 | ...)
Show SMILES Cn1cc(cc1C(N)=O)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C31H30N4O4/c1-3-29(37)34-15-22(16-34)27-12-20-11-19(18-7-8-18)9-10-24(20)31(39)35(27)26-6-4-5-23(25(26)17-36)21-13-28(30(32)38)33(2)14-21/h3-6,9-14,18,22,36H,1,7-8,15-17H2,2H3,(H2,32,38)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435482
PNG
(US10570118, Example 36)
Show SMILES CN(Cc1cc2cc(ccc2c(=O)n1-c1cccc(c1CO)-c1cccc(c1)C(N)=O)C1CC1)C(=O)C=C
Show InChI InChI=1S/C31H29N3O4/c1-3-29(36)33(2)17-24-16-23-14-20(19-10-11-19)12-13-26(23)31(38)34(24)28-9-5-8-25(27(28)18-35)21-6-4-7-22(15-21)30(32)37/h3-9,12-16,19,35H,1,10-11,17-18H2,2H3,(H2,32,37)
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n/an/a 580n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM435483
PNG
(US10570118, Example 37)
Show SMILES Nc1nccc(c1F)-c1cccc(c1CO)-n1c(cc2cc(ccc2c1=O)C1CC1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C31H29FN4O3/c1-2-28(38)35-13-11-20(16-35)27-15-21-14-19(18-6-7-18)8-9-22(21)31(39)36(27)26-5-3-4-23(25(26)17-37)24-10-12-34-30(33)29(24)32/h2-5,8-10,12,14-15,18,20,37H,1,6-7,11,13,16-17H2,(H2,33,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
A Lanthscreen Eu Kinase Binding assay (Life Technologies) was performed to quantitate the ability of test compounds to bind to BTK. The assay is base...


US Patent US10570118 (2020)


BindingDB Entry DOI: 10.7270/Q2DJ5J1T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%