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Patent code US10570121

Compile Data Set for Download or QSAR

Found 412 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246933
PNG
(CHEMBL4094432 | US10570121, Example 165)
Show SMILES COC(C1CCN(CC1)C(=O)CO)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C26H31Cl2N3O5/c1-14-10-15(2)29-25(34)19(14)12-31-9-6-17-20(27)11-18(23(28)22(17)26(31)35)24(36-3)16-4-7-30(8-5-16)21(33)13-32/h10-11,16,24,32H,4-9,12-13H2,1-3H3,(H,29,34)
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0n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246933
PNG
(CHEMBL4094432 | US10570121, Example 165)
Show SMILES COC(C1CCN(CC1)C(=O)CO)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C26H31Cl2N3O5/c1-14-10-15(2)29-25(34)19(14)12-31-9-6-17-20(27)11-18(23(28)22(17)26(31)35)24(36-3)16-4-7-30(8-5-16)21(33)13-32/h10-11,16,24,32H,4-9,12-13H2,1-3H3,(H,29,34)
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0n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435562
PNG
(US10570121, Example 72 | US10570121, Example 73)
Show SMILES COC(C1CCN(CC1)C=O)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246941
PNG
(CHEMBL4062421 | US10570121, Example 51)
Show SMILES COC(C1CCOCC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C24H28Cl2N2O4/c1-13-10-14(2)27-23(29)18(13)12-28-7-4-16-19(25)11-17(21(26)20(16)24(28)30)22(31-3)15-5-8-32-9-6-15/h10-11,15,22H,4-9,12H2,1-3H3,(H,27,29)
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0n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435546
PNG
(US10570121, Example 56)
Show SMILES Cc1cc(OC(F)F)c(CN2CCc3c(Cl)cc(C(CO)C4CCOCC4)c(Cl)c3C2=O)c(=O)[nH]1
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0n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435551
PNG
(US10570121, Example 61 | US10570121, Example 71)
Show SMILES COC(C1CCN(CC1)C(=O)CC#N)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435691
PNG
(US10570121, Example 197 | US10570121, Example 198)
Show SMILES COc1cc(C)[nH]c(=O)c1CN1CCc2c(C)cc(C(C)C3COC3)c(Cl)c2C1=O
PDB

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0.0100n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435577
PNG
(US10570121, Example 87)
Show SMILES COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc(C(C)C3CN(C)C3)c(Cl)c2C1=O
PDB

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0.0100n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246932
PNG
(CHEMBL4073864 | US10570121, Example 112)
Show SMILES COC(C1CCN(CC1)C(=O)CO)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C26H31Cl2N3O6/c1-14-10-20(36-2)18(25(34)29-14)12-31-9-6-16-19(27)11-17(23(28)22(16)26(31)35)24(37-3)15-4-7-30(8-5-15)21(33)13-32/h10-11,15,24,32H,4-9,12-13H2,1-3H3,(H,29,34)
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0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246939
PNG
(CHEMBL4072089 | US10570121, Example 110)
Show SMILES COC(C1CCN(CC1)C(C)=O)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C26H31Cl2N3O4/c1-14-11-15(2)29-25(33)20(14)13-31-10-7-18-21(27)12-19(23(28)22(18)26(31)34)24(35-4)17-5-8-30(9-6-17)16(3)32/h11-12,17,24H,5-10,13H2,1-4H3,(H,29,33)
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0.0400n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435642
PNG
(US10570121, Example 148 | US10570121, Example 149 ...)
Show SMILES COC(C1CCS(=O)(=O)C1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435694
PNG
(US10570121, Example 200 | US10570121, Example 201)
Show SMILES COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc(C(C)C3CCN(CC3)C(=O)CO)c(Cl)c2C1=O
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435640
PNG
(US10570121, Example 146 | US10570121, Example 147)
Show SMILES COC(C1CCN(C)CC1)c1cc(Br)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246940
PNG
(CHEMBL4071056 | US10570121, Example 137)
Show SMILES COC(C1CCN(C)CC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C25H31Cl2N3O3/c1-14-11-15(2)28-24(31)19(14)13-30-10-7-17-20(26)12-18(22(27)21(17)25(30)32)23(33-4)16-5-8-29(3)9-6-16/h11-12,16,23H,5-10,13H2,1-4H3,(H,28,31)
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435609
PNG
(US10570121, Example 118 | US10570121, Example 119)
Show SMILES COC(C1CCN(CC1)C=O)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246927
PNG
(CHEMBL4060447 | US10570121, Example 127)
Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)
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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435614
PNG
(US10570121, Example 122 | US10570121, Example 123)
Show SMILES COC(C1CCN(CC1)C(C)=O)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435660
PNG
(US10570121, Example 166 | US10570121, Example 167)
Show SMILES COC(C1CCNCC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435689
PNG
(US10570121, Example 195 | US10570121, Example 196)
Show SMILES CC(C1COC1)c1cc(C)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435574
PNG
(US10570121, Example 84 | US10570121, Example 85)
Show SMILES COC(C1CCOC1)c1cc(C)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246967
PNG
(CHEMBL4080228 | US10570121, Example 81)
Show SMILES CO[C@H](C1COC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1
PDB

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0.200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435638
PNG
(US10570121, Example 144 | US10570121, Example 145)
Show SMILES COC(C1COC1)c1cc(C)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435670
PNG
(US10570121, Example 176 | US10570121, Example 177)
Show SMILES COC(C1CN(C1)S(C)(=O)=O)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.300n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246933
PNG
(CHEMBL4094432 | US10570121, Example 165)
Show SMILES COC(C1CCN(CC1)C(=O)CO)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C26H31Cl2N3O5/c1-14-10-15(2)29-25(34)19(14)12-31-9-6-17-20(27)11-18(23(28)22(17)26(31)35)24(36-3)16-4-7-30(8-5-16)21(33)13-32/h10-11,16,24,32H,4-9,12-13H2,1-3H3,(H,29,34)
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0.300n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435685
PNG
(US10570121, Example 191 | US10570121, Example 192)
Show SMILES COc1cc(C)[nH]c(=O)c1CN1CCc2c(C)cc(C(C)C3CN(C3)S(C)(=O)=O)c(Cl)c2C1=O
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246930
PNG
(CHEMBL4067961 | US10570121, Example 153)
Show SMILES COC(C1CS(=O)(=O)C1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C22H24Cl2N2O5S/c1-11-6-12(2)25-21(27)16(11)8-26-5-4-14-17(23)7-15(19(24)18(14)22(26)28)20(31-3)13-9-32(29,30)10-13/h6-7,13,20H,4-5,8-10H2,1-3H3,(H,25,27)
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0.300n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435591
PNG
(US10570121, Example 100 | US10570121, Example 101)
Show SMILES Cc1cc(C)c(CN2CCc3c(C)cc(C(CO)C4CCOCC4)c(Cl)c3C2=O)c(=O)[nH]1
PDB

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0.300n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435605
PNG
(US10570121, Example 114 | US10570121, Example 115)
Show SMILES COC(C1CCS(=O)CC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246942
PNG
(CHEMBL4061264 | US10570121, Example 163)
Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C23H26Cl2N2O4/c1-12-8-13(2)26-22(28)17(12)10-27-6-4-15-18(24)9-16(20(25)19(15)23(27)29)21(30-3)14-5-7-31-11-14/h8-9,14,21H,4-7,10-11H2,1-3H3,(H,26,28)
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246931
PNG
(CHEMBL4065249 | US10570121, Example 117)
Show SMILES COC(C1CCS(=O)(=O)CC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C24H28Cl2N2O5S/c1-13-10-14(2)27-23(29)18(13)12-28-7-4-16-19(25)11-17(21(26)20(16)24(28)30)22(33-3)15-5-8-34(31,32)9-6-15/h10-11,15,22H,4-9,12H2,1-3H3,(H,27,29)
PDB

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0.400n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246942
PNG
(CHEMBL4061264 | US10570121, Example 163)
Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C23H26Cl2N2O4/c1-12-8-13(2)26-22(28)17(12)10-27-6-4-15-18(24)9-16(20(25)19(15)23(27)29)21(30-3)14-5-7-31-11-14/h8-9,14,21H,4-7,10-11H2,1-3H3,(H,26,28)
PDB

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0.400n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435573
PNG
(US10570121, Example 83)
Show SMILES CO[C@H]([C@@H]1CCOC1)c1cc(C)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435632
PNG
(US10570121, Example 138 | US10570121, Example 139)
Show SMILES COC(C1CN(C1)C(=O)CO)c1cc(Br)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.5n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435677
PNG
(US10570121, Example 183 | US10570121, Example 184)
Show SMILES CC(C1CN(C1)C(=O)CO)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.600n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246937
PNG
(CHEMBL4079181 | US10570121, Example 157)
Show SMILES COC(C1CCN(CC1)C1COC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C27H33Cl2N3O4/c1-15-10-16(2)30-26(33)21(15)12-32-9-6-19-22(28)11-20(24(29)23(19)27(32)34)25(35-3)17-4-7-31(8-5-17)18-13-36-14-18/h10-11,17-18,25H,4-9,12-14H2,1-3H3,(H,30,33)
PDB

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0.600n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435668
PNG
(US10570121, Example 174 | US10570121, Example 175)
Show SMILES COC(C1CN(C)C1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.600n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435597
PNG
(US10570121, Example 106)
Show SMILES COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc([C@H](CO)[C@@H]3CCCO3)c(Cl)c2C1=O
PDB

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0.600n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435683
PNG
(US10570121, Example 189 | US10570121, Example 190)
Show SMILES CC(C1CNC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435662
PNG
(US10570121, Example 168 | US10570121, Example 169)
Show SMILES COC(C1CCN(CC1)C(=O)CO)c1cc(C)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.700n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435625
PNG
(US10570121, Example 131)
Show SMILES COC(C1CCS(=O)(=O)CC1)c1cc(C)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.700n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435699
PNG
(US10570121, Example 205)
Show SMILES CC(N1CCNCC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.700n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435622
PNG
(US10570121, Example 128 | US10570121, Example 129)
Show SMILES COC(C1CN(C1)C(=O)CO)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435666
PNG
(US10570121, Example 172 | US10570121, Example 173)
Show SMILES COC(C1CN(C1)C(=O)[C@H](C)O)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435664
PNG
(US10570121, Example 170 | US10570121, Example 171)
Show SMILES COC(C1CN(C1)C(=O)[C@@H](C)O)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435642
PNG
(US10570121, Example 148 | US10570121, Example 149 ...)
Show SMILES COC(C1CCS(=O)(=O)C1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435604
PNG
(US10570121, Example 113)
Show SMILES COC(C1CCN(C1)C(=O)CO)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435596
PNG
(US10570121, Example 105)
Show SMILES COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc([C@H](CO)[C@H]3CCCO3)c(Cl)c2C1=O
PDB

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Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50246927
PNG
(CHEMBL4060447 | US10570121, Example 127)
Show SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl
Show InChI InChI=1S/C23H26Cl2N2O5/c1-12-8-18(30-2)16(22(28)26-12)10-27-6-4-14-17(24)9-15(20(25)19(14)23(27)29)21(31-3)13-5-7-32-11-13/h8-9,13,21H,4-7,10-11H2,1-3H3,(H,26,28)
PDB

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0.900n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435687
PNG
(US10570121, Example 193 | US10570121, Example 194)
Show SMILES CC(C1CN(C1)S(C)(=O)=O)c1cc(C)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
UniChem
US Patent
1n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM435681
PNG
(US10570121, Example 187 | US10570121, Example 188)
Show SMILES CC(C1CN(C)C1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
UniChem
US Patent
1n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...


US Patent US10570121 (2020)


BindingDB Entry DOI: 10.7270/Q28W3GQD
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%