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Patent code US10570141

Compile Data Set for Download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM435712
PNG
(US10570141, Example 1)
Show SMILES CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C21H27N7O2S/c1-31(29,30)19-12-15-13-24-21(26-20(15)28(19)16-4-2-3-5-16)25-18-7-6-17(14-23-18)27-10-8-22-9-11-27/h6-7,12-14,16,22H,2-5,8-11H2,1H3,(H,23,24,25,26)
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n/an/a 0.800n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM435716
PNG
(US10570141, Example 5)
Show SMILES CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)C3CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C22H28N6O2S/c1-31(29,30)20-12-17-14-25-22(27-21(17)28(20)18-4-2-3-5-18)26-19-7-6-16(13-24-19)15-8-10-23-11-9-15/h6-7,12-15,18,23H,2-5,8-11H2,1H3,(H,24,25,26,27)
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n/an/a 1.46n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM435713
PNG
(US10570141, Example 2)
Show SMILES CCS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C22H29N7O2S/c1-2-32(30,31)20-13-16-14-25-22(27-21(16)29(20)17-5-3-4-6-17)26-19-8-7-18(15-24-19)28-11-9-23-10-12-28/h7-8,13-15,17,23H,2-6,9-12H2,1H3,(H,24,25,26,27)
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n/an/a 2.12n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM148264
PNG
(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)
Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
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n/an/a 2.14n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM435717
PNG
(US10570141, Example 6)
Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C3=CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C24H29N7O/c1-30(2)23(32)20-13-18-15-27-24(29-22(18)31(20)19-5-3-4-6-19)28-21-8-7-17(14-26-21)16-9-11-25-12-10-16/h7-9,13-15,19,25H,3-6,10-12H2,1-2H3,(H,26,27,28,29)
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n/an/a 2.37n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM435715
PNG
(US10570141, Example 4)
Show SMILES CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)C3=CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C22H26N6O2S/c1-31(29,30)20-12-17-14-25-22(27-21(17)28(20)18-4-2-3-5-18)26-19-7-6-16(13-24-19)15-8-10-23-11-9-15/h6-8,12-14,18,23H,2-5,9-11H2,1H3,(H,24,25,26,27)
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n/an/a 2.57n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM435714
PNG
(US10570141, Example 3)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3cc(n(C4CCCC4)c3n2)S(C)(=O)=O)nc1
Show InChI InChI=1S/C24H33N7O2S/c1-29(2)18-10-12-30(13-11-18)20-8-9-21(25-16-20)27-24-26-15-17-14-22(34(3,32)33)31(23(17)28-24)19-6-4-5-7-19/h8-9,14-16,18-19H,4-7,10-13H2,1-3H3,(H,25,26,27,28)
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n/an/a 3.40n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM435712
PNG
(US10570141, Example 1)
Show SMILES CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C21H27N7O2S/c1-31(29,30)19-12-15-13-24-21(26-20(15)28(19)16-4-2-3-5-16)25-18-7-6-17(14-23-18)27-10-8-22-9-11-27/h6-7,12-14,16,22H,2-5,8-11H2,1H3,(H,23,24,25,26)
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n/an/a 5.70n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM435716
PNG
(US10570141, Example 5)
Show SMILES CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)C3CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C22H28N6O2S/c1-31(29,30)20-12-17-14-25-22(27-21(17)28(20)18-4-2-3-5-18)26-19-7-6-16(13-24-19)15-8-10-23-11-9-15/h6-7,12-15,18,23H,2-5,8-11H2,1H3,(H,24,25,26,27)
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n/an/a 9.85n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM435715
PNG
(US10570141, Example 4)
Show SMILES CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)C3=CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C22H26N6O2S/c1-31(29,30)20-12-17-14-25-22(27-21(17)28(20)18-4-2-3-5-18)26-19-7-6-16(13-24-19)15-8-10-23-11-9-15/h6-8,12-14,18,23H,2-5,9-11H2,1H3,(H,24,25,26,27)
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n/an/a 11.1n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM435714
PNG
(US10570141, Example 3)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3cc(n(C4CCCC4)c3n2)S(C)(=O)=O)nc1
Show InChI InChI=1S/C24H33N7O2S/c1-29(2)18-10-12-30(13-11-18)20-8-9-21(25-16-20)27-24-26-15-17-14-22(34(3,32)33)31(23(17)28-24)19-6-4-5-7-19/h8-9,14-16,18-19H,4-7,10-13H2,1-3H3,(H,25,26,27,28)
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n/an/a 18.7n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM435713
PNG
(US10570141, Example 2)
Show SMILES CCS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C22H29N7O2S/c1-2-32(30,31)20-13-16-14-25-22(27-21(16)29(20)17-5-3-4-6-17)26-19-8-7-18(15-24-19)28-11-9-23-10-12-28/h7-8,13-15,17,23H,2-6,9-12H2,1H3,(H,24,25,26,27)
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n/an/a 21n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM148264
PNG
(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)
Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
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n/an/a 26.9n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM435717
PNG
(US10570141, Example 6)
Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C3=CCNCC3)nc2n1C1CCCC1
Show InChI InChI=1S/C24H29N7O/c1-30(2)23(32)20-13-18-15-27-24(29-22(18)31(20)19-5-3-4-6-19)28-21-8-7-17(14-26-21)16-9-11-25-12-10-16/h7-9,13-15,19,25H,3-6,10-12H2,1-2H3,(H,26,27,28,29)
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n/an/a 30.6n/an/an/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...


US Patent US10570141 (2020)


BindingDB Entry DOI: 10.7270/Q2RV0R3H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%