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Patent code US10570167

Compile Data Set for Download or QSAR

Found 249 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5'-nucleotidase


(Homo sapiens (Human))
BDBM435853
PNG
(US10570167, Cpd. # 179)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)N2CCCNC2=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C24H25ClFN7O8/c25-22-30-17(27)15-18(31-22)33(10-29-15)19-14(26)16(34)13(41-19)9-40-24(20(35)36,21(37)38)8-11-2-4-12(5-3-11)32-7-1-6-28-23(32)39/h2-5,10,13-14,16,19,34H,1,6-9H2,(H,28,39)(H,35,36)(H,37,38)(H2,27,30,31)/t13-,14+,16-,19-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435855
PNG
(US10570167, Cpd. # 181)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2cccc(F)c2O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C26H22ClF2N5O8/c27-25-32-20(30)17-21(33-25)34(10-31-17)22-16(29)19(36)15(42-22)9-41-26(23(37)38,24(39)40)8-11-4-6-12(7-5-11)13-2-1-3-14(28)18(13)35/h1-7,10,15-16,19,22,35-36H,8-9H2,(H,37,38)(H,39,40)(H2,30,32,33)/t15-,16+,19-,22-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435840
PNG
(US10570167, Cpd. # 160)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccccc2O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C26H23ClFN5O8/c27-25-31-20(29)18-21(32-25)33(11-30-18)22-17(28)19(35)16(41-22)10-40-26(23(36)37,24(38)39)9-12-5-7-13(8-6-12)14-3-1-2-4-15(14)34/h1-8,11,16-17,19,22,34-35H,9-10H2,(H,36,37)(H,38,39)(H2,29,31,32)/t16-,17+,19-,22-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435852
PNG
(US10570167, Cpd. # 178)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)N2CCCCS2(=O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C24H26ClFN6O9S/c25-23-29-18(27)16-19(30-23)31(11-28-16)20-15(26)17(33)14(41-20)10-40-24(21(34)35,22(36)37)9-12-3-5-13(6-4-12)32-7-1-2-8-42(32,38)39/h3-6,11,14-15,17,20,33H,1-2,7-10H2,(H,34,35)(H,36,37)(H2,27,29,30)/t14-,15+,17-,20-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435830
PNG
(US10570167, Cpd. # 150)
Show SMILES COc1ccccc1C(=O)Nc1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C28H26ClFN6O9/c1-43-16-5-3-2-4-15(16)23(38)33-14-8-6-13(7-9-14)10-28(25(39)40,26(41)42)44-11-17-20(37)18(30)24(45-17)36-12-32-19-21(31)34-27(29)35-22(19)36/h2-9,12,17-18,20,24,37H,10-11H2,1H3,(H,33,38)(H,39,40)(H,41,42)(H2,31,34,35)/t17-,18+,20-,24-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435849
PNG
(US10570167, Cpd. # 175)
Show SMILES CCOC(=O)c1ccccc1-c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C29H27ClFN5O9/c1-2-43-25(38)17-6-4-3-5-16(17)15-9-7-14(8-10-15)11-29(26(39)40,27(41)42)44-12-18-21(37)19(31)24(45-18)36-13-33-20-22(32)34-28(30)35-23(20)36/h3-10,13,18-19,21,24,37H,2,11-12H2,1H3,(H,39,40)(H,41,42)(H2,32,34,35)/t18-,19+,21-,24-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435848
PNG
(US10570167, Cpd. # 174)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)[C@](O)(C#C)[C@H]1O
Show InChI InChI=1S/C22H20ClN5O8/c1-2-21(34)12(9-35-22(18(30)31,19(32)33)8-11-6-4-3-5-7-11)36-17(14(21)29)28-10-25-13-15(24)26-20(23)27-16(13)28/h1,3-7,10,12,14,17,29,34H,8-9H2,(H,30,31)(H,32,33)(H2,24,26,27)/t12-,14+,17-,21-/m1/s1
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n/an/a<20n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435814
PNG
(US10570167, Cpd. # 129)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)N2CCCCC2=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C25H26ClFN6O8/c26-24-30-19(28)17-20(31-24)33(11-29-17)21-16(27)18(35)14(41-21)10-40-25(22(36)37,23(38)39)9-12-4-6-13(7-5-12)32-8-2-1-3-15(32)34/h4-7,11,14,16,18,21,35H,1-3,8-10H2,(H,36,37)(H,38,39)(H2,28,30,31)/t14-,16+,18-,21-/m1/s1
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Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435866
PNG
(US10570167, Cpd. # 198)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OCc3ccccc3)cc2)(C(O)=O)c2nn[nH]n2)[C@@H](O)[C@H]1O
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n/an/a 29n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420007
PNG
(US10472364, Compound 79 | US10570167, Cpd. # 79)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccccc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C26H23ClFN5O7/c27-25-31-20(29)18-21(32-25)33(12-30-18)22-17(28)19(34)16(40-22)11-39-26(23(35)36,24(37)38)10-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,12,16-17,19,22,34H,10-11H2,(H,35,36)(H,37,38)(H2,29,31,32)/t16-,17+,19-,22-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435822
PNG
(US10570167, Cpd. # 140 | US10570167, Cpd. # 141)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(NC(=O)c3cccs3)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C25H22ClFN6O8S/c26-24-31-18(28)16-19(32-24)33(10-29-16)21-15(27)17(34)13(41-21)9-40-25(22(36)37,23(38)39)8-11-3-5-12(6-4-11)30-20(35)14-2-1-7-42-14/h1-7,10,13,15,17,21,34H,8-9H2,(H,30,35)(H,36,37)(H,38,39)(H2,28,31,32)/t13-,15+,17-,21-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435831
PNG
(US10570167, Cpd. # 151)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccccc2C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C27H23ClFN5O9/c28-26-32-20(30)18-21(33-26)34(11-31-18)22-17(29)19(35)16(43-22)10-42-27(24(38)39,25(40)41)9-12-5-7-13(8-6-12)14-3-1-2-4-15(14)23(36)37/h1-8,11,16-17,19,22,35H,9-10H2,(H,36,37)(H,38,39)(H,40,41)(H2,30,32,33)/t16-,17+,19-,22-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419992
PNG
(US10472364, Compound 65 | US10570167, Cpd. # 65)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OCc3ccccc3)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C27H25ClFN5O8/c28-26-32-21(30)19-22(33-26)34(13-31-19)23-18(29)20(35)17(42-23)12-41-27(24(36)37,25(38)39)10-14-6-8-16(9-7-14)40-11-15-4-2-1-3-5-15/h1-9,13,17-18,20,23,35H,10-12H2,(H,36,37)(H,38,39)(H2,30,32,33)/t17-,18+,20-,23-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435807
PNG
(US10570167, Cpd. # 122)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(NC(=O)c3ccccc3)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C27H24ClFN6O8/c28-26-33-20(30)18-21(34-26)35(12-31-18)23-17(29)19(36)16(43-23)11-42-27(24(38)39,25(40)41)10-13-6-8-15(9-7-13)32-22(37)14-4-2-1-3-5-14/h1-9,12,16-17,19,23,36H,10-11H2,(H,32,37)(H,38,39)(H,40,41)(H2,30,33,34)/t16-,17+,19-,23-/m1/s1
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Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435832
PNG
(US10570167, Cpd. # 152)
Show SMILES Cc1n[nH]c(C)c1-c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
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n/an/a 34n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435837
PNG
(US10570167, Cpd. # 157)
Show SMILES Cc1noc(C)c1-c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C25H24ClFN6O8/c1-10-15(11(2)41-32-10)13-5-3-12(4-6-13)7-25(22(35)36,23(37)38)39-8-14-18(34)16(27)21(40-14)33-9-29-17-19(28)30-24(26)31-20(17)33/h3-6,9,14,16,18,21,34H,7-8H2,1-2H3,(H,35,36)(H,37,38)(H2,28,30,31)/t14-,16+,18-,21-/m1/s1
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Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419981
PNG
(US10472364, Compound 58 | US10570167, Cpd. # 58)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(C(O)=O)c(F)c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF2N5O9/c22-20-27-14(25)12-15(28-20)29(6-26-12)16-11(24)13(30)10(38-16)5-37-21(18(33)34,19(35)36)4-7-1-2-8(17(31)32)9(23)3-7/h1-3,6,10-11,13,16,30H,4-5H2,(H,31,32)(H,33,34)(H,35,36)(H2,25,27,28)/t10-,11+,13-,16-/m1/s1
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n/an/a 38n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420019
PNG
(US10472364, Compound 89 | US10570167, Cpd. # 89)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OCC(F)(F)F)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C22H20ClF4N5O8/c23-20-30-15(28)13-16(31-20)32(8-29-13)17-12(24)14(33)11(40-17)6-39-21(18(34)35,19(36)37)5-9-1-3-10(4-2-9)38-7-22(25,26)27/h1-4,8,11-12,14,17,33H,5-7H2,(H,34,35)(H,36,37)(H2,28,30,31)/t11-,12+,14-,17-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420009
PNG
(US10472364, Compound 80 | US10570167, Cpd. # 80)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(Cl)cc2F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H17Cl2F2N5O7/c21-8-2-1-7(9(23)3-8)4-20(17(31)32,18(33)34)35-5-10-13(30)11(24)16(36-10)29-6-26-12-14(25)27-19(22)28-15(12)29/h1-3,6,10-11,13,16,30H,4-5H2,(H,31,32)(H,33,34)(H2,25,27,28)/t10-,11+,13-,16-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435835
PNG
(US10570167, Cpd. # 155)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccc(cc2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C27H23ClFN5O9/c28-26-32-20(30)18-21(33-26)34(11-31-18)22-17(29)19(35)16(43-22)10-42-27(24(38)39,25(40)41)9-12-1-3-13(4-2-12)14-5-7-15(8-6-14)23(36)37/h1-8,11,16-17,19,22,35H,9-10H2,(H,36,37)(H,38,39)(H,40,41)(H2,30,32,33)/t16-,17+,19-,22-/m1/s1
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n/an/a 47n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435851
PNG
(US10570167, Cpd. # 177)
Show SMILES Cc1[nH]ncc1-c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
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n/an/a 48n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435829
PNG
(US10570167, Cpd. # 149)
Show SMILES C[C@@]1(O)[C@@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)O[C@H]([C@@H]1O)n1cnc2c(N)nc(Cl)nc12
Show InChI InChI=1S/C21H22ClN5O8/c1-20(33)11(8-34-21(17(29)30,18(31)32)7-10-5-3-2-4-6-10)35-16(13(20)28)27-9-24-12-14(23)25-19(22)26-15(12)27/h2-6,9,11,13,16,28,33H,7-8H2,1H3,(H,29,30)(H,31,32)(H2,23,25,26)/t11-,13+,16-,20-/m1/s1
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n/an/a 51n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419984
PNG
(US10472364, Compound 60 | US10570167, Cpd. # 60)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(c(F)c2)C(F)(F)F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H17ClF5N5O7/c22-19-30-14(28)12-15(31-19)32(6-29-12)16-11(24)13(33)10(39-16)5-38-20(17(34)35,18(36)37)4-7-1-2-8(9(23)3-7)21(25,26)27/h1-3,6,10-11,13,16,33H,4-5H2,(H,34,35)(H,36,37)(H2,28,30,31)/t10-,11+,13-,16-/m1/s1
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n/an/a 51n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435868
PNG
(US10570167, Cpd. # 200)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccccc2C(O)=O)(C(O)=O)c2nn[nH]n2)[C@@H](O)[C@H]1O
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n/an/a 53n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435841
PNG
(US10570167, Cpd. # 162)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)N2CCCC2=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C24H24ClFN6O8/c25-23-29-18(27)16-19(30-23)32(10-28-16)20-15(26)17(34)13(40-20)9-39-24(21(35)36,22(37)38)8-11-3-5-12(6-4-11)31-7-1-2-14(31)33/h3-6,10,13,15,17,20,34H,1-2,7-9H2,(H,35,36)(H,37,38)(H2,27,29,30)/t13-,15+,17-,20-/m1/s1
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n/an/a 54n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435850
PNG
(US10570167, Cpd. # 176)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccccn2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C25H22ClFN6O7/c26-24-31-19(28)17-20(32-24)33(11-30-17)21-16(27)18(34)15(40-21)10-39-25(22(35)36,23(37)38)9-12-4-6-13(7-5-12)14-3-1-2-8-29-14/h1-8,11,15-16,18,21,34H,9-10H2,(H,35,36)(H,37,38)(H2,28,31,32)/t15-,16+,18-,21-/m1/s1
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n/an/a 56n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419950
PNG
(US10472364, Compound 36 | US10570167, Cpd. # 36)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OC(F)(F)F)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF4N5O8/c22-19-29-14(27)12-15(30-19)31(7-28-12)16-11(23)13(32)10(38-16)6-37-20(17(33)34,18(35)36)5-8-1-3-9(4-2-8)39-21(24,25)26/h1-4,7,10-11,13,16,32H,5-6H2,(H,33,34)(H,35,36)(H2,27,29,30)/t10-,11+,13-,16-/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435822
PNG
(US10570167, Cpd. # 140 | US10570167, Cpd. # 141)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(NC(=O)c3cccs3)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C25H22ClFN6O8S/c26-24-31-18(28)16-19(32-24)33(10-29-16)21-15(27)17(34)13(41-21)9-40-25(22(36)37,23(38)39)8-11-3-5-12(6-4-11)30-20(35)14-2-1-7-42-14/h1-7,10,13,15,17,21,34H,8-9H2,(H,30,35)(H,36,37)(H,38,39)(H2,28,31,32)/t13-,15+,17-,21-/m1/s1
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n/an/a 60n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420016
PNG
(US10472364, Compound 86 | US10570167, Cpd. # 86)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)S(N)(=O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H20ClFN6O9S/c21-19-26-14(23)12-15(27-19)28(7-25-12)16-11(22)13(29)10(37-16)6-36-20(17(30)31,18(32)33)5-8-1-3-9(4-2-8)38(24,34)35/h1-4,7,10-11,13,16,29H,5-6H2,(H,30,31)(H,32,33)(H2,23,26,27)(H2,24,34,35)/t10-,11+,13-,16-/m1/s1
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n/an/a 62n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435826
PNG
(US10570167, Cpd. # 144)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccc(F)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C26H22ClF2N5O7/c27-25-32-20(30)18-21(33-25)34(11-31-18)22-17(29)19(35)16(41-22)10-40-26(23(36)37,24(38)39)9-12-1-3-13(4-2-12)14-5-7-15(28)8-6-14/h1-8,11,16-17,19,22,35H,9-10H2,(H,36,37)(H,38,39)(H2,30,32,33)/t16-,17+,19-,22-/m1/s1
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n/an/a 65n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435797
PNG
(US10570167, Cpd. # 110)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc3OC(F)(F)Oc3c2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H17ClF3N5O9/c22-19-28-14(26)12-15(29-19)30(6-27-12)16-11(23)13(31)10(37-16)5-36-20(17(32)33,18(34)35)4-7-1-2-8-9(3-7)39-21(24,25)38-8/h1-3,6,10-11,13,16,31H,4-5H2,(H,32,33)(H,34,35)(H2,26,28,29)/t10-,11+,13-,16-/m1/s1
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n/an/a 66n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435824
PNG
(US10570167, Cpd. # 142)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2cccnc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C25H22ClFN6O7/c26-24-31-19(28)17-20(32-24)33(11-30-17)21-16(27)18(34)15(40-21)10-39-25(22(35)36,23(37)38)8-12-3-5-13(6-4-12)14-2-1-7-29-9-14/h1-7,9,11,15-16,18,21,34H,8,10H2,(H,35,36)(H,37,38)(H2,28,31,32)/t15-,16+,18-,21-/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420019
PNG
(US10472364, Compound 89 | US10570167, Cpd. # 89)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(OCC(F)(F)F)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C22H20ClF4N5O8/c23-20-30-15(28)13-16(31-20)32(8-29-13)17-12(24)14(33)11(40-17)6-39-21(18(34)35,19(36)37)5-9-1-3-10(4-2-9)38-7-22(25,26)27/h1-4,8,11-12,14,17,33H,5-7H2,(H,34,35)(H,36,37)(H2,28,30,31)/t11-,12+,14-,17-/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420003
PNG
(US10472364, Compound 76 | US10570167, Cpd. # 76)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2csc(c2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C19H17ClFN5O9S/c20-18-24-12(22)10-13(25-18)26(5-23-10)14-9(21)11(27)7(35-14)3-34-19(16(30)31,17(32)33)2-6-1-8(15(28)29)36-4-6/h1,4-5,7,9,11,14,27H,2-3H2,(H,28,29)(H,30,31)(H,32,33)(H2,22,24,25)/t7-,9+,11-,14-/m1/s1
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n/an/a 74n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435833
PNG
(US10570167, Cpd. # 153)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C27H25ClFN5O9S/c1-44(40,41)16-8-6-15(7-9-16)14-4-2-13(3-5-14)10-27(24(36)37,25(38)39)42-11-17-20(35)18(29)23(43-17)34-12-31-19-21(30)32-26(28)33-22(19)34/h2-9,12,17-18,20,23,35H,10-11H2,1H3,(H,36,37)(H,38,39)(H2,30,32,33)/t17-,18+,20-,23-/m1/s1
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n/an/a 74n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435839
PNG
(US10570167, Cpd. # 159)
Show SMILES Nc1ncc(cn1)-c1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C24H22ClFN8O7/c25-22-32-17(27)15-18(33-22)34(9-31-15)19-14(26)16(35)13(41-19)8-40-24(20(36)37,21(38)39)5-10-1-3-11(4-2-10)12-6-29-23(28)30-7-12/h1-4,6-7,9,13-14,16,19,35H,5,8H2,(H,36,37)(H,38,39)(H2,27,32,33)(H2,28,29,30)/t13-,14+,16-,19-/m1/s1
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n/an/a 76n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420017
PNG
(US10472364, Compound 87 | US10570167, Cpd. # 87)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)C(=O)NCCC(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C24H24ClFN6O10/c25-23-30-17(27)15-18(31-23)32(9-29-15)20-14(26)16(35)12(42-20)8-41-24(21(37)38,22(39)40)7-10-1-3-11(4-2-10)19(36)28-6-5-13(33)34/h1-4,9,12,14,16,20,35H,5-8H2,(H,28,36)(H,33,34)(H,37,38)(H,39,40)(H2,27,30,31)/t12-,14+,16-,20-/m1/s1
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n/an/a 83n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435836
PNG
(US10570167, Cpd. # 156)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccncc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C25H22ClFN6O7/c26-24-31-19(28)17-20(32-24)33(11-30-17)21-16(27)18(34)15(40-21)10-39-25(22(35)36,23(37)38)9-12-1-3-13(4-2-12)14-5-7-29-8-6-14/h1-8,11,15-16,18,21,34H,9-10H2,(H,35,36)(H,37,38)(H2,28,31,32)/t15-,16+,18-,21-/m1/s1
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n/an/a 86n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435814
PNG
(US10570167, Cpd. # 129)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)N2CCCCC2=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C25H26ClFN6O8/c26-24-30-19(28)17-20(31-24)33(11-29-17)21-16(27)18(35)14(41-21)10-40-25(22(36)37,23(38)39)9-12-4-6-13(7-5-12)32-8-2-1-3-15(32)34/h4-7,11,14,16,18,21,35H,1-3,8-10H2,(H,36,37)(H,38,39)(H2,28,30,31)/t14-,16+,18-,21-/m1/s1
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n/an/a 86n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420006
PNG
(US10472364, Compound 78 | US10570167, Cpd. # 78)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(CC(O)=O)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C22H21ClFN5O9/c23-21-27-16(25)14-17(28-21)29(8-26-14)18-13(24)15(32)11(38-18)7-37-22(19(33)34,20(35)36)6-10-3-1-9(2-4-10)5-12(30)31/h1-4,8,11,13,15,18,32H,5-7H2,(H,30,31)(H,33,34)(H,35,36)(H2,25,27,28)/t11-,13+,15-,18-/m1/s1
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n/an/a 86n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435818
PNG
(US10570167, Cpd. # 134)
Show SMILES CCCCCSc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C25H28ClFN4O7S/c1-2-3-7-10-39-20-17-19(29-24(26)30-20)31(13-28-17)21-16(27)18(32)15(38-21)12-37-25(22(33)34,23(35)36)11-14-8-5-4-6-9-14/h4-6,8-9,13,15-16,18,21,32H,2-3,7,10-12H2,1H3,(H,33,34)(H,35,36)/t15-,16+,18-,21-/m1/s1
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n/an/a 87n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419948
PNG
(US10472364, Compound 34 | US10570167, Cpd. # 34)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)C#N)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClFN6O7/c22-20-27-15(25)13-16(28-20)29(8-26-13)17-12(23)14(30)11(36-17)7-35-21(18(31)32,19(33)34)5-9-1-3-10(6-24)4-2-9/h1-4,8,11-12,14,17,30H,5,7H2,(H,31,32)(H,33,34)(H2,25,27,28)/t11-,12+,14-,17-/m1/s1
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n/an/a 97n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435816
PNG
(US10570167, Cpd. # 131)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(I)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H18ClFIN5O7/c21-19-26-14(24)12-15(27-19)28(7-25-12)16-11(22)13(29)10(35-16)6-34-20(17(30)31,18(32)33)5-8-1-3-9(23)4-2-8/h1-4,7,10-11,13,16,29H,5-6H2,(H,30,31)(H,32,33)(H2,24,26,27)/t10-,11+,13-,16-/m1/s1
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n/an/a 98n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419979
PNG
(US10472364, Compound 57 | US10570167, Cpd. # 57)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2F)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF2N5O9/c22-20-27-14(25)12-15(28-20)29(6-26-12)16-11(24)13(30)10(38-16)5-37-21(18(33)34,19(35)36)4-8-2-1-7(17(31)32)3-9(8)23/h1-3,6,10-11,13,16,30H,4-5H2,(H,31,32)(H,33,34)(H,35,36)(H2,25,27,28)/t10-,11+,13-,16-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435795
PNG
(US10570167, Cpd. # 108)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(F)c(F)c2F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C20H16ClF4N5O7/c21-19-28-14(26)12-15(29-19)30(5-27-12)16-11(25)13(31)8(37-16)4-36-20(17(32)33,18(34)35)3-6-1-2-7(22)10(24)9(6)23/h1-2,5,8,11,13,16,31H,3-4H2,(H,32,33)(H,34,35)(H2,26,28,29)/t8-,11+,13-,16-/m1/s1
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n/an/a 104n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM420023
PNG
(US10472364, Compound 95 | US10570167, Cpd. # 95)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2ccccc2C#N)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C27H22ClFN6O7/c28-26-33-21(31)19-22(34-26)35(12-32-19)23-18(29)20(36)17(42-23)11-41-27(24(37)38,25(39)40)9-13-5-7-14(8-6-13)16-4-2-1-3-15(16)10-30/h1-8,12,17-18,20,23,36H,9,11H2,(H,37,38)(H,39,40)(H2,31,33,34)/t17-,18+,20-,23-/m1/s1
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n/an/a 105n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435838
PNG
(US10570167, Cpd. # 158)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)-c2cccs2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C24H21ClFN5O7S/c25-23-29-18(27)16-19(30-23)31(10-28-16)20-15(26)17(32)13(38-20)9-37-24(21(33)34,22(35)36)8-11-3-5-12(6-4-11)14-2-1-7-39-14/h1-7,10,13,15,17,20,32H,8-9H2,(H,33,34)(H,35,36)(H2,27,29,30)/t13-,15+,17-,20-/m1/s1
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n/an/a 105n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435827
PNG
(US10570167, Cpd. # 145)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)C(O)=O)(C(O)=O)C(O)=O)[C@H](O)[C@@H]1F
Show InChI InChI=1S/C21H19ClFN5O9/c22-20-26-14(24)12-15(27-20)28(7-25-12)16-11(23)13(29)10(37-16)6-36-21(18(32)33,19(34)35)5-8-1-3-9(4-2-8)17(30)31/h1-4,7,10-11,13,16,29H,5-6H2,(H,30,31)(H,32,33)(H,34,35)(H2,24,26,27)/t10-,11+,13+,16-/m1/s1
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n/an/a 106n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM419934
PNG
(US10472364, Compound 20 | US10570167, Cpd. # 20)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)C(F)(F)F)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F
Show InChI InChI=1S/C21H18ClF4N5O7/c22-19-29-14(27)12-15(30-19)31(7-28-12)16-11(23)13(32)10(38-16)6-37-20(17(33)34,18(35)36)5-8-1-3-9(4-2-8)21(24,25)26/h1-4,7,10-11,13,16,32H,5-6H2,(H,33,34)(H,35,36)(H2,27,29,30)/t10-,11+,13-,16-/m1/s1
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n/an/a 109n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
5'-nucleotidase


(Homo sapiens (Human))
BDBM435820
PNG
(US10570167, Cpd. # 136)
Show SMILES CC(=O)Nc1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C22H22ClFN6O8/c1-9(31)27-11-4-2-10(3-5-11)6-22(19(33)34,20(35)36)37-7-12-15(32)13(24)18(38-12)30-8-26-14-16(25)28-21(23)29-17(14)30/h2-5,8,12-13,15,18,32H,6-7H2,1H3,(H,27,31)(H,33,34)(H,35,36)(H2,25,28,29)/t12-,13+,15-,18-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Calithera Biosciences, Inc.

US Patent


Assay Description
For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...


US Patent US10570167 (2020)


BindingDB Entry DOI: 10.7270/Q2CN769R
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%