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Patent code US10576087

Compile Data Set for Download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210051
PNG
(US10576087, Compound 2.29 | US9273046, 2.29 | US98...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(no3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C25H18N4O4/c30-19-9-7-15-18(10-11-26-24(15)27-19)31-14-6-8-17-16(12-14)20-21(22(20)32-17)25-28-23(29-33-25)13-4-2-1-3-5-13/h1-6,8,10-12,20-22H,7,9H2,(H,26,27,30)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<0.25n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210052
PNG
(US10576087, Compound 2.30 | US9273046, 2.30)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<0.25n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210020
PNG
(US10576087, Compound 2.26 | US9273046, 2.26 | US98...)
Show SMILES Clc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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PC sid
UniChem
US Patent
n/an/a<0.25n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210021
PNG
(US10576087, Compound 2.27 | US9273046, 2.27 | US98...)
Show SMILES Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<0.25n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210037
PNG
(US10576087, Compound 2.1 | US9273046, 2.1 | US9895...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1
PDB

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UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210022
PNG
(US10576087, Compound 2.31 | US9273046, 2.31 | US98...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(c[nH]3)-c3ccncc3)ccnc2N1
PDB

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PC sid
UniChem
US Patent
n/an/a 0.350n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210015
PNG
(US10576087, Compound 2.21 | US9273046, 2.21 | US98...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4cc5CCCc5cc4[nH]3)ccnc2N1
PDB

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PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM372977
PNG
(US10576087, Compound 2.4a | US9895376, Compound 2....)
Show SMILES Cc1cc2[nH]c(nc2cc1F)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
PDB

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US Patent
n/an/a 0.540n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210044
PNG
(US10576087, Compound 2.4 | US9273046, 2.4 | US9895...)
Show SMILES Cc1cc2[nH]c(nc2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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PC sid
UniChem
US Patent
n/an/a<0.560n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210024
PNG
(US10576087, Compound 2.33 | US9273046, 2.33 | US98...)
Show SMILES FC(F)(F)c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210002
PNG
(US10576087, Compound 2.8 | US9273046, 2.8 | US9895...)
Show SMILES Cc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.710n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210052
PNG
(US10576087, Compound 2.30 | US9273046, 2.30)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.720n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210023
PNG
(US10576087, Compound 2.32 | US9273046, 2.32 | US98...)
Show SMILES Clc1ccccc1-c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210016
PNG
(US10576087, Compound 2.22 | US9273046, 2.22 | US98...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM372967
PNG
(US10576087, Compound 2.2a | US9895376, Compound 2....)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210015
PNG
(US10576087, Compound 2.21 | US9273046, 2.21 | US98...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4cc5CCCc5cc4[nH]3)ccnc2N1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210034
PNG
(US10576087, Compound 1.1 | US9273046, 1.1 | US9895...)
Show SMILES O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210038
PNG
(US10576087, Compound 2.2 | US9273046, 2.2 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210013
PNG
(US10576087, Compound 2.19 | US9273046, 2.19 | US98...)
Show SMILES Fc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210007
PNG
(US10576087, Compound 2.13 | US9273046, 2.13 | US98...)
Show SMILES Brc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210001
PNG
(US10576087, Compound 2.7 | US9273046, 2.7 | US9895...)
Show SMILES Fc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.10n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210044
PNG
(US10576087, Compound 2.4 | US9273046, 2.4 | US9895...)
Show SMILES Cc1cc2[nH]c(nc2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210021
PNG
(US10576087, Compound 2.27 | US9273046, 2.27 | US98...)
Show SMILES Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM372985
PNG
(US10576087, Compound 2.5b | US9895376, Compound 2....)
Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM372978
PNG
(US10576087, Compound 2.4b | US9895376, Compound 2....)
Show SMILES Cc1cc2[nH]c(nc2cc1F)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM372974
PNG
(US10576087, Compound 2.3a | US9895376, Compound 2....)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210037
PNG
(US10576087, Compound 2.1 | US9273046, 2.1 | US9895...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210032
PNG
(US10576087, Compound 3.7 | US9273046, 3.7 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)OCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210051
PNG
(US10576087, Compound 2.29 | US9273046, 2.29 | US98...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(no3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C25H18N4O4/c30-19-9-7-15-18(10-11-26-24(15)27-19)31-14-6-8-17-16(12-14)20-21(22(20)32-17)25-28-23(29-33-25)13-4-2-1-3-5-13/h1-6,8,10-12,20-22H,7,9H2,(H,26,27,30)
PDB

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UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210023
PNG
(US10576087, Compound 2.32 | US9273046, 2.32 | US98...)
Show SMILES Clc1ccccc1-c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210005
PNG
(US10576087, Compound 2.11 | US9273046, 2.11 | US98...)
Show SMILES Fc1cc2nc([nH]c2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM372977
PNG
(US10576087, Compound 2.4a | US9895376, Compound 2....)
Show SMILES Cc1cc2[nH]c(nc2cc1F)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
PDB

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UniChem
US Patent
n/an/a 3.40n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210009
PNG
(US10576087, Compound 2.15 | US9273046, 2.15 | US98...)
Show SMILES Cn1c(nc2ccccc12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C25H20N4O3/c1-29-17-5-3-2-4-16(17)27-25(29)22-21-15-12-13(6-8-18(15)32-23(21)22)31-19-10-11-26-24-14(19)7-9-20(30)28-24/h2-6,8,10-12,21-23H,7,9H2,1H3,(H,26,28,30)
PDB

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UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210022
PNG
(US10576087, Compound 2.31 | US9273046, 2.31 | US98...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(c[nH]3)-c3ccncc3)ccnc2N1
PDB

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UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210002
PNG
(US10576087, Compound 2.8 | US9273046, 2.8 | US9895...)
Show SMILES Cc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210010
PNG
(US10576087, Compound 2.16 | US9273046, 2.16 | US98...)
Show SMILES COc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210016
PNG
(US10576087, Compound 2.22 | US9273046, 2.22 | US98...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM372973
PNG
(US10576087, Compound 2.3b | US9895376, Compound 2....)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
PDB

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US Patent
n/an/a 4n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210006
PNG
(US10576087, Compound 2.12 | US9273046, 2.12 | US98...)
Show SMILES Clc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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US Patent
n/an/a 4.10n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210025
PNG
(US10576087, Compound 2.34 | US9273046, 2.34 | US98...)
Show SMILES OCCn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C27H21F3N4O4/c28-27(29,30)13-1-4-18-17(11-13)32-26(34(18)9-10-35)23-22-16-12-14(2-5-19(16)38-24(22)23)37-20-7-8-31-25-15(20)3-6-21(36)33-25/h1-2,4-5,7-8,11-12,22-24,35H,3,6,9-10H2,(H,31,33,36)
PDB

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PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210018
PNG
(US10576087, Compound 2.24 | US9273046, 2.24 | US98...)
Show SMILES Cn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C26H19F3N4O3/c1-33-17-5-2-12(26(27,28)29)10-16(17)31-25(33)22-21-15-11-13(3-6-18(15)36-23(21)22)35-19-8-9-30-24-14(19)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210014
PNG
(US10576087, Compound 2.20 | US9273046, 2.20 | US98...)
Show SMILES CC(C)(C)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210000
PNG
(US10576087, Compound 2.6 | US9273046, 2.6 | US9895...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccc(cc4[nH]3)C#N)ccnc2N1
PDB

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UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210003
PNG
(US10576087, Compound 2.9 | US9273046, 2.9 | US9895...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccncc4[nH]3)ccnc2N1
PDB

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UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210041
PNG
(US10576087, Compound 2.3 | US9273046, 2.3 | US9895...)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210047
PNG
(US10576087, Compound 2.5 | US9273046, 2.5 | US9895...)
Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210011
PNG
(US10576087, Compound 2.17 | US9273046, 2.17 | US98...)
Show SMILES Fc1cc2[nH]c(nc2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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PC sid
UniChem
US Patent
n/an/a 5.40n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210036
PNG
(US10576087, Compound 1.3 | US9273046, 1.3)
Show SMILES O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4s3)ccnc2N1
Show InChI InChI=1S/C25H19N3O2S/c29-21-8-7-15-19(9-10-26-24(15)28-21)30-14-6-5-13-11-17-22(16(13)12-14)23(17)25-27-18-3-1-2-4-20(18)31-25/h1-6,9-10,12,17,22-23H,7-8,11H2,(H,26,28,29)
PDB

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PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210011
PNG
(US10576087, Compound 2.17 | US9273046, 2.17 | US98...)
Show SMILES Fc1cc2[nH]c(nc2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210005
PNG
(US10576087, Compound 2.11 | US9273046, 2.11 | US98...)
Show SMILES Fc1cc2nc([nH]c2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210024
PNG
(US10576087, Compound 2.33 | US9273046, 2.33 | US98...)
Show SMILES FC(F)(F)c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210012
PNG
(US10576087, Compound 2.18 | US9273046, 2.18 | US98...)
Show SMILES FC(F)(F)c1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210028
PNG
(US10576087, Compound 3.1 | US9273046, 3.1)
Show SMILES CNC(=O)c1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1
PDB

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PC sid
UniChem
US Patent
n/an/a 6.5n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM372967
PNG
(US10576087, Compound 2.2a | US9895376, Compound 2....)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
PDB

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PC sid
UniChem
US Patent
n/an/a 6.70n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210038
PNG
(US10576087, Compound 2.2 | US9273046, 2.2 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 7.20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210007
PNG
(US10576087, Compound 2.13 | US9273046, 2.13 | US98...)
Show SMILES Brc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 7.20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM372968
PNG
(US10576087, Compound 2.2b | US9895376, Compound 2....)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
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n/an/a 8.80n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210008
PNG
(US10576087, Compound 2.14 | US9273046, 2.14 | US98...)
Show SMILES FC(F)(F)Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 9.70n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210001
PNG
(US10576087, Compound 2.7 | US9273046, 2.7 | US9895...)
Show SMILES Fc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 10n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM372974
PNG
(US10576087, Compound 2.3a | US9895376, Compound 2....)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
PDB

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n/an/a 11n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210034
PNG
(US10576087, Compound 1.1 | US9273046, 1.1 | US9895...)
Show SMILES O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1
PDB

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n/an/a 11n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210013
PNG
(US10576087, Compound 2.19 | US9273046, 2.19 | US98...)
Show SMILES Fc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 11n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM372985
PNG
(US10576087, Compound 2.5b | US9895376, Compound 2....)
Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
PDB

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n/an/a 11n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210057
PNG
(US10576087, Compound 2.35 | US9273046, 2.35 | US98...)
Show SMILES Cc1cc(Oc2ccnc3NC(=O)CCc23)cc2C3C(Oc12)C3c1nc2ccc(cc2[nH]1)C(F)(F)F
PDB

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n/an/a 12n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210035
PNG
(US10576087, Compound 1.2 | US9273046, 1.2 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 12n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210006
PNG
(US10576087, Compound 2.12 | US9273046, 2.12 | US98...)
Show SMILES Clc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 12n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210009
PNG
(US10576087, Compound 2.15 | US9273046, 2.15 | US98...)
Show SMILES Cn1c(nc2ccccc12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C25H20N4O3/c1-29-17-5-3-2-4-16(17)27-25(29)22-21-15-12-13(6-8-18(15)32-23(21)22)31-19-10-11-26-24-14(19)7-9-20(30)28-24/h2-6,8,10-12,21-23H,7,9H2,1H3,(H,26,28,30)
PDB

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n/an/a 12n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210010
PNG
(US10576087, Compound 2.16 | US9273046, 2.16 | US98...)
Show SMILES COc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 15n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210020
PNG
(US10576087, Compound 2.26 | US9273046, 2.26 | US98...)
Show SMILES Clc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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US Patent
n/an/a 16n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210047
PNG
(US10576087, Compound 2.5 | US9273046, 2.5 | US9895...)
Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 19n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210053
PNG
(US10576087, Compound 3.5 | US9273046, 3.5 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ncnc5[nH]cnc45)cc3C12
PDB

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n/an/a 20n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM372981
PNG
(US10576087, Compound 2.5a | US9895376, Compound 2....)
Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
PDB

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n/an/a 21n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM372978
PNG
(US10576087, Compound 2.4b | US9895376, Compound 2....)
Show SMILES Cc1cc2[nH]c(nc2cc1F)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
PDB

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n/an/a 21n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210000
PNG
(US10576087, Compound 2.6 | US9273046, 2.6 | US9895...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccc(cc4[nH]3)C#N)ccnc2N1
PDB

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n/an/a 22n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210027
PNG
(US10576087, Compound 2.37 | US9273046, 2.37 | US98...)
Show SMILES Cc1cc2nc([nH]c2cc1F)C1C2Oc3cc(Cl)c(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 23n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210004
PNG
(US10576087, Compound 2.10 | US9273046, 2.10 | US98...)
Show SMILES FC(F)(F)c1cc(Cl)c2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 25n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210032
PNG
(US10576087, Compound 3.7 | US9273046, 3.7 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)OCc45)cc3C12
PDB

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n/an/a 26n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210008
PNG
(US10576087, Compound 2.14 | US9273046, 2.14 | US98...)
Show SMILES FC(F)(F)Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 28n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210025
PNG
(US10576087, Compound 2.34 | US9273046, 2.34 | US98...)
Show SMILES OCCn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C27H21F3N4O4/c28-27(29,30)13-1-4-18-17(11-13)32-26(34(18)9-10-35)23-22-16-12-14(2-5-19(16)38-24(22)23)37-20-7-8-31-25-15(20)3-6-21(36)33-25/h1-2,4-5,7-8,11-12,22-24,35H,3,6,9-10H2,(H,31,33,36)
PDB

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n/an/a 30n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM372973
PNG
(US10576087, Compound 2.3b | US9895376, Compound 2....)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
PDB

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n/an/a 32n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210026
PNG
(US10576087, Compound 2.36 | US9273046, 2.36 | US98...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3cc(Cl)c(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 32n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210041
PNG
(US10576087, Compound 2.3 | US9273046, 2.3 | US9895...)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 32n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210014
PNG
(US10576087, Compound 2.20 | US9273046, 2.20 | US98...)
Show SMILES CC(C)(C)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 33n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210017
PNG
(US10576087, Compound 2.23 | US9273046, 2.23 | US98...)
Show SMILES Cn1c(nc2ccc(cc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C26H19F3N4O3/c1-33-17-10-12(26(27,28)29)2-5-16(17)31-25(33)22-21-15-11-13(3-6-18(15)36-23(21)22)35-19-8-9-30-24-14(19)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34)
PDB

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n/an/a 35n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210019
PNG
(US10576087, Compound 2.25 | US9273046, 2.25 | US98...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3c(cccc3Oc3ccnc4NC(=O)CCc34)C12
PDB

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n/an/a 36n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210003
PNG
(US10576087, Compound 2.9 | US9273046, 2.9 | US9895...)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccncc4[nH]3)ccnc2N1
PDB

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n/an/a 42n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210018
PNG
(US10576087, Compound 2.24 | US9273046, 2.24 | US98...)
Show SMILES Cn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C26H19F3N4O3/c1-33-17-5-2-12(26(27,28)29)10-16(17)31-25(33)22-21-15-11-13(3-6-18(15)36-23(21)22)35-19-8-9-30-24-14(19)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34)
PDB

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n/an/a 47n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM372968
PNG
(US10576087, Compound 2.2b | US9895376, Compound 2....)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
PDB

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n/an/a 53n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210028
PNG
(US10576087, Compound 3.1 | US9273046, 3.1)
Show SMILES CNC(=O)c1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1
PDB

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n/an/a 56n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210053
PNG
(US10576087, Compound 3.5 | US9273046, 3.5 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ncnc5[nH]cnc45)cc3C12
PDB

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n/an/a 56n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210030
PNG
(US10576087, Compound 3.4 | US9273046, 3.4 | US9895...)
Show SMILES FC(F)(F)c1c[nH]c(n1)-c1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1
PDB

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n/an/a 56n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210057
PNG
(US10576087, Compound 2.35 | US9273046, 2.35 | US98...)
Show SMILES Cc1cc(Oc2ccnc3NC(=O)CCc23)cc2C3C(Oc12)C3c1nc2ccc(cc2[nH]1)C(F)(F)F
PDB

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n/an/a 61n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210035
PNG
(US10576087, Compound 1.2 | US9273046, 1.2 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 72n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210004
PNG
(US10576087, Compound 2.10 | US9273046, 2.10 | US98...)
Show SMILES FC(F)(F)c1cc(Cl)c2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 80n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210050
PNG
(US10576087, Compound 2.28 | US9273046, 2.28)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccc(cc4[nH]3)-c3ccccc3)ccnc2N1
PDB

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n/an/a 81n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210054
PNG
(US10576087, Compound 3.6 | US9273046, 3.6 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccncc4)cc3C12
PDB

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US Patent
n/an/a 86n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210036
PNG
(US10576087, Compound 1.3 | US9273046, 1.3)
Show SMILES O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4s3)ccnc2N1
Show InChI InChI=1S/C25H19N3O2S/c29-21-8-7-15-19(9-10-26-24(15)28-21)30-14-6-5-13-11-17-22(16(13)12-14)23(17)25-27-18-3-1-2-4-20(18)31-25/h1-6,9-10,12,17,22-23H,7-8,11H2,(H,26,28,29)
PDB

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n/an/a 88n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210012
PNG
(US10576087, Compound 2.18 | US9273046, 2.18 | US98...)
Show SMILES FC(F)(F)c1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 89n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210029
PNG
(US10576087, Compound 3.3 | US9273046, 3.3)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5[nH]ccc45)cc3C12
PDB

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US Patent
n/an/a 104n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210026
PNG
(US10576087, Compound 2.36 | US9273046, 2.36 | US98...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3cc(Cl)c(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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US Patent
n/an/a 117n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM372981
PNG
(US10576087, Compound 2.5a | US9895376, Compound 2....)
Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
PDB

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US Patent
n/an/a 126n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210027
PNG
(US10576087, Compound 2.37 | US9273046, 2.37 | US98...)
Show SMILES Cc1cc2nc([nH]c2cc1F)C1C2Oc3cc(Cl)c(Oc4ccnc5NC(=O)CCc45)cc3C12
PDB

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n/an/a 173n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210017
PNG
(US10576087, Compound 2.23 | US9273046, 2.23 | US98...)
Show SMILES Cn1c(nc2ccc(cc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C26H19F3N4O3/c1-33-17-10-12(26(27,28)29)2-5-16(17)31-25(33)22-21-15-11-13(3-6-18(15)36-23(21)22)35-19-8-9-30-24-14(19)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34)
PDB

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US Patent
n/an/a 204n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210031
PNG
(US10576087, Compound 3.2 | US9273046, 3.2 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccncn4)cc3C12
PDB

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US Patent
n/an/a 223n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210050
PNG
(US10576087, Compound 2.28 | US9273046, 2.28)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccc(cc4[nH]3)-c3ccccc3)ccnc2N1
PDB

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US Patent
n/an/a 232n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210030
PNG
(US10576087, Compound 3.4 | US9273046, 3.4 | US9895...)
Show SMILES FC(F)(F)c1c[nH]c(n1)-c1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1
PDB

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n/an/a 291n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210033
PNG
(US10576087, Compound 3.8 | US9273046, 3.8 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4c(Cl)cnc5NC(=O)CCc45)cc3C12
PDB

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US Patent
n/an/a 432n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210054
PNG
(US10576087, Compound 3.6 | US9273046, 3.6 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccncc4)cc3C12
PDB

GoogleScholar
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US Patent
n/an/a 518n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210029
PNG
(US10576087, Compound 3.3 | US9273046, 3.3)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5[nH]ccc45)cc3C12
PDB

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US Patent
n/an/a 522n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210031
PNG
(US10576087, Compound 3.2 | US9273046, 3.2 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccncn4)cc3C12
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 569n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210019
PNG
(US10576087, Compound 2.25 | US9273046, 2.25 | US98...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3c(cccc3Oc3ccnc4NC(=O)CCc34)C12
PDB

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UniChem
US Patent
n/an/a 849n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210033
PNG
(US10576087, Compound 3.8 | US9273046, 3.8 | US9895...)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4c(Cl)cnc5NC(=O)CCc45)cc3C12
PDB

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PC cid
PC sid
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210056
PNG
(US10576087, Compound Intermediate II | US9273046, ...)
Show SMILES OC(=O)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C18H14N2O5/c21-13-4-2-9-12(5-6-19-17(9)20-13)24-8-1-3-11-10(7-8)14-15(18(22)23)16(14)25-11/h1,3,5-7,14-16H,2,4H2,(H,22,23)(H,19,20,21)
PDB

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US Patent
n/an/a 2.92E+3n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM210055
PNG
(US10576087, Compound Intermediate I | US9273046, I...)
Show SMILES OC(=O)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C19H16N2O4/c22-15-4-3-11-14(5-6-20-18(11)21-15)25-10-2-1-9-7-13-16(12(9)8-10)17(13)19(23)24/h1-2,5-6,8,13,16-17H,3-4,7H2,(H,23,24)(H,20,21,22)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210055
PNG
(US10576087, Compound Intermediate I | US9273046, I...)
Show SMILES OC(=O)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C19H16N2O4/c22-15-4-3-11-14(5-6-20-18(11)21-15)25-10-2-1-9-7-13-16(12(9)8-10)17(13)19(23)24/h1-2,5-6,8,13,16-17H,3-4,7H2,(H,23,24)(H,20,21,22)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM210056
PNG
(US10576087, Compound Intermediate II | US9273046, ...)
Show SMILES OC(=O)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1S/C18H14N2O5/c21-13-4-2-9-12(5-6-19-17(9)20-13)24-8-1-3-11-10(7-8)14-15(18(22)23)16(14)25-11/h1,3,5-7,14-16H,2,4H2,(H,22,23)(H,19,20,21)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



BEIGENE, LTD.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US10576087 (2020)


BindingDB Entry DOI: 10.7270/Q2HM5BVQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%