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Patent code US10577308

Compile Data Set for Download or QSAR

Found 216 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432084
PNG
(US10577308, Compound 562)
Show SMILES Cc1cccc(C)c1OCCCNC(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C22H25N3O/c1-17-9-7-10-18(2)22(17)26-16-8-15-25-21(19-11-3-5-13-23-19)20-12-4-6-14-24-20/h3-7,9-14,21,25H,8,15-16H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432084
PNG
(US10577308, Compound 562)
Show SMILES Cc1cccc(C)c1OCCCNC(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C22H25N3O/c1-17-9-7-10-18(2)22(17)26-16-8-15-25-21(19-11-3-5-13-23-19)20-12-4-6-14-24-20/h3-7,9-14,21,25H,8,15-16H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432084
PNG
(US10577308, Compound 562)
Show SMILES Cc1cccc(C)c1OCCCNC(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C22H25N3O/c1-17-9-7-10-18(2)22(17)26-16-8-15-25-21(19-11-3-5-13-23-19)20-12-4-6-14-24-20/h3-7,9-14,21,25H,8,15-16H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432084
PNG
(US10577308, Compound 562)
Show SMILES Cc1cccc(C)c1OCCCNC(c1ccccn1)c1ccccn1
Show InChI InChI=1S/C22H25N3O/c1-17-9-7-10-18(2)22(17)26-16-8-15-25-21(19-11-3-5-13-23-19)20-12-4-6-14-24-20/h3-7,9-14,21,25H,8,15-16H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432087
PNG
(US10577308, Compound 558)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(c1)-c1cncnc1
Show InChI InChI=1S/C22H25N3O/c1-17-6-3-7-18(2)22(17)26-11-5-10-23-13-19-8-4-9-20(12-19)21-14-24-16-25-15-21/h3-4,6-9,12,14-16,23H,5,10-11,13H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432082
PNG
(US10577308, Compound 553)
Show SMILES CC(NCCCOc1c(C)cccc1C)c1ccccc1
Show InChI InChI=1S/C19H25NO/c1-15-9-7-10-16(2)19(15)21-14-8-13-20-17(3)18-11-5-4-6-12-18/h4-7,9-12,17,20H,8,13-14H2,1-3H3
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n/an/a 200n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432082
PNG
(US10577308, Compound 553)
Show SMILES CC(NCCCOc1c(C)cccc1C)c1ccccc1
Show InChI InChI=1S/C19H25NO/c1-15-9-7-10-16(2)19(15)21-14-8-13-20-17(3)18-11-5-4-6-12-18/h4-7,9-12,17,20H,8,13-14H2,1-3H3
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n/an/a 200n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432087
PNG
(US10577308, Compound 558)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(c1)-c1cncnc1
Show InChI InChI=1S/C22H25N3O/c1-17-6-3-7-18(2)22(17)26-11-5-10-23-13-19-8-4-9-20(12-19)21-14-24-16-25-15-21/h3-4,6-9,12,14-16,23H,5,10-11,13H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432082
PNG
(US10577308, Compound 553)
Show SMILES CC(NCCCOc1c(C)cccc1C)c1ccccc1
Show InChI InChI=1S/C19H25NO/c1-15-9-7-10-16(2)19(15)21-14-8-13-20-17(3)18-11-5-4-6-12-18/h4-7,9-12,17,20H,8,13-14H2,1-3H3
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n/an/a 300n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432087
PNG
(US10577308, Compound 558)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(c1)-c1cncnc1
Show InChI InChI=1S/C22H25N3O/c1-17-6-3-7-18(2)22(17)26-11-5-10-23-13-19-8-4-9-20(12-19)21-14-24-16-25-15-21/h3-4,6-9,12,14-16,23H,5,10-11,13H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432082
PNG
(US10577308, Compound 553)
Show SMILES CC(NCCCOc1c(C)cccc1C)c1ccccc1
Show InChI InChI=1S/C19H25NO/c1-15-9-7-10-16(2)19(15)21-14-8-13-20-17(3)18-11-5-4-6-12-18/h4-7,9-12,17,20H,8,13-14H2,1-3H3
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n/an/a 300n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432087
PNG
(US10577308, Compound 558)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(c1)-c1cncnc1
Show InChI InChI=1S/C22H25N3O/c1-17-6-3-7-18(2)22(17)26-11-5-10-23-13-19-8-4-9-20(12-19)21-14-24-16-25-15-21/h3-4,6-9,12,14-16,23H,5,10-11,13H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432075
PNG
(US10577308, Compound 536)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H27NO/c1-19-10-8-11-20(2)24(19)26-17-9-16-25-18-22-14-6-7-15-23(22)21-12-4-3-5-13-21/h3-8,10-15,25H,9,16-18H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432075
PNG
(US10577308, Compound 536)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H27NO/c1-19-10-8-11-20(2)24(19)26-17-9-16-25-18-22-14-6-7-15-23(22)21-12-4-3-5-13-21/h3-8,10-15,25H,9,16-18H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432070
PNG
(US10577308, Compound 525)
Show SMILES COc1cccc(CNCCCOc2c(C)cccc2C)c1
Show InChI InChI=1S/C19H25NO2/c1-15-7-4-8-16(2)19(15)22-12-6-11-20-14-17-9-5-10-18(13-17)21-3/h4-5,7-10,13,20H,6,11-12,14H2,1-3H3
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n/an/a 400n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432087
PNG
(US10577308, Compound 558)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(c1)-c1cncnc1
Show InChI InChI=1S/C22H25N3O/c1-17-6-3-7-18(2)22(17)26-11-5-10-23-13-19-8-4-9-20(12-19)21-14-24-16-25-15-21/h3-4,6-9,12,14-16,23H,5,10-11,13H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432070
PNG
(US10577308, Compound 525)
Show SMILES COc1cccc(CNCCCOc2c(C)cccc2C)c1
Show InChI InChI=1S/C19H25NO2/c1-15-7-4-8-16(2)19(15)22-12-6-11-20-14-17-9-5-10-18(13-17)21-3/h4-5,7-10,13,20H,6,11-12,14H2,1-3H3
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n/an/a 400n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432058
PNG
(US10577308, Compound 518)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1
Show InChI InChI=1S/C18H23NO/c1-15-8-6-9-16(2)18(15)20-13-7-12-19-14-17-10-4-3-5-11-17/h3-6,8-11,19H,7,12-14H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432058
PNG
(US10577308, Compound 518)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1
Show InChI InChI=1S/C18H23NO/c1-15-8-6-9-16(2)18(15)20-13-7-12-19-14-17-10-4-3-5-11-17/h3-6,8-11,19H,7,12-14H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432077
PNG
(US10577308, Compound 530)
Show SMILES COc1ccccc1CNCCCOc1c(C)cccc1C
Show InChI InChI=1S/C19H25NO2/c1-15-8-6-9-16(2)19(15)22-13-7-12-20-14-17-10-4-5-11-18(17)21-3/h4-6,8-11,20H,7,12-14H2,1-3H3
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n/an/a 800n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432077
PNG
(US10577308, Compound 530)
Show SMILES COc1ccccc1CNCCCOc1c(C)cccc1C
Show InChI InChI=1S/C19H25NO2/c1-15-8-6-9-16(2)19(15)22-13-7-12-20-14-17-10-4-5-11-18(17)21-3/h4-6,8-11,20H,7,12-14H2,1-3H3
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n/an/a 800n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432060
PNG
(US10577308, Compound 520)
Show SMILES COc1ccc(CNCCCOc2c(C)cccc2C)cc1
Show InChI InChI=1S/C19H25NO2/c1-15-6-4-7-16(2)19(15)22-13-5-12-20-14-17-8-10-18(21-3)11-9-17/h4,6-11,20H,5,12-14H2,1-3H3
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432060
PNG
(US10577308, Compound 520)
Show SMILES COc1ccc(CNCCCOc2c(C)cccc2C)cc1
Show InChI InChI=1S/C19H25NO2/c1-15-6-4-7-16(2)19(15)22-13-5-12-20-14-17-8-10-18(21-3)11-9-17/h4,6-11,20H,5,12-14H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432078
PNG
(US10577308, Compound 551)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1F
Show InChI InChI=1S/C18H22FNO/c1-14-7-5-8-15(2)18(14)21-12-6-11-20-13-16-9-3-4-10-17(16)19/h3-5,7-10,20H,6,11-13H2,1-2H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432078
PNG
(US10577308, Compound 551)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1F
Show InChI InChI=1S/C18H22FNO/c1-14-7-5-8-15(2)18(14)21-12-6-11-20-13-16-9-3-4-10-17(16)19/h3-5,7-10,20H,6,11-13H2,1-2H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432077
PNG
(US10577308, Compound 530)
Show SMILES COc1ccccc1CNCCCOc1c(C)cccc1C
Show InChI InChI=1S/C19H25NO2/c1-15-8-6-9-16(2)19(15)22-13-7-12-20-14-17-10-4-5-11-18(17)21-3/h4-6,8-11,20H,7,12-14H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432077
PNG
(US10577308, Compound 530)
Show SMILES COc1ccccc1CNCCCOc1c(C)cccc1C
Show InChI InChI=1S/C19H25NO2/c1-15-8-6-9-16(2)19(15)22-13-7-12-20-14-17-10-4-5-11-18(17)21-3/h4-6,8-11,20H,7,12-14H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432073
PNG
(US10577308, Compound 552)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(F)c1
Show InChI InChI=1S/C18H22FNO/c1-14-6-3-7-15(2)18(14)21-11-5-10-20-13-16-8-4-9-17(19)12-16/h3-4,6-9,12,20H,5,10-11,13H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432073
PNG
(US10577308, Compound 552)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(F)c1
Show InChI InChI=1S/C18H22FNO/c1-14-6-3-7-15(2)18(14)21-11-5-10-20-13-16-8-4-9-17(19)12-16/h3-4,6-9,12,20H,5,10-11,13H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432080
PNG
(US10577308, Compound 540)
Show SMILES Cc1cccc(C)c1OCCCNCc1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H29N3O/c1-20-10-8-11-21(2)26(20)30-17-9-16-27-18-24-23-14-6-7-15-25(23)29(28-24)19-22-12-4-3-5-13-22/h3-8,10-15,27H,9,16-19H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432080
PNG
(US10577308, Compound 540)
Show SMILES Cc1cccc(C)c1OCCCNCc1nn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H29N3O/c1-20-10-8-11-21(2)26(20)30-17-9-16-27-18-24-23-14-6-7-15-25(23)29(28-24)19-22-12-4-3-5-13-22/h3-8,10-15,27H,9,16-19H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432087
PNG
(US10577308, Compound 558)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(c1)-c1cncnc1
Show InChI InChI=1S/C22H25N3O/c1-17-6-3-7-18(2)22(17)26-11-5-10-23-13-19-8-4-9-20(12-19)21-14-24-16-25-15-21/h3-4,6-9,12,14-16,23H,5,10-11,13H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432075
PNG
(US10577308, Compound 536)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H27NO/c1-19-10-8-11-20(2)24(19)26-17-9-16-25-18-22-14-6-7-15-23(22)21-12-4-3-5-13-21/h3-8,10-15,25H,9,16-18H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432075
PNG
(US10577308, Compound 536)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1-c1ccccc1
Show InChI InChI=1S/C24H27NO/c1-19-10-8-11-20(2)24(19)26-17-9-16-25-18-22-14-6-7-15-23(22)21-12-4-3-5-13-21/h3-8,10-15,25H,9,16-18H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432064
PNG
(US10577308, Compound 531)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H22F3NO2/c1-14-5-3-6-15(2)18(14)24-12-4-11-23-13-16-7-9-17(10-8-16)25-19(20,21)22/h3,5-10,23H,4,11-13H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432064
PNG
(US10577308, Compound 531)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H22F3NO2/c1-14-5-3-6-15(2)18(14)24-12-4-11-23-13-16-7-9-17(10-8-16)25-19(20,21)22/h3,5-10,23H,4,11-13H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432083
PNG
(US10577308, Compound 554)
Show SMILES Cc1cccc(C)c1OCCCNC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H27NO/c1-19-11-9-12-20(2)24(19)26-18-10-17-25-23(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h3-9,11-16,23,25H,10,17-18H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432061
PNG
(US10577308, Compound 521)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccc(F)cc1
Show InChI InChI=1S/C18H22FNO/c1-14-5-3-6-15(2)18(14)21-12-4-11-20-13-16-7-9-17(19)10-8-16/h3,5-10,20H,4,11-13H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432061
PNG
(US10577308, Compound 521)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccc(F)cc1
Show InChI InChI=1S/C18H22FNO/c1-14-5-3-6-15(2)18(14)21-12-4-11-20-13-16-7-9-17(19)10-8-16/h3,5-10,20H,4,11-13H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432083
PNG
(US10577308, Compound 554)
Show SMILES Cc1cccc(C)c1OCCCNC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H27NO/c1-19-11-9-12-20(2)24(19)26-18-10-17-25-23(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h3-9,11-16,23,25H,10,17-18H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432060
PNG
(US10577308, Compound 520)
Show SMILES COc1ccc(CNCCCOc2c(C)cccc2C)cc1
Show InChI InChI=1S/C19H25NO2/c1-15-6-4-7-16(2)19(15)22-13-5-12-20-14-17-8-10-18(21-3)11-9-17/h4,6-11,20H,5,12-14H2,1-3H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432060
PNG
(US10577308, Compound 520)
Show SMILES COc1ccc(CNCCCOc2c(C)cccc2C)cc1
Show InChI InChI=1S/C19H25NO2/c1-15-6-4-7-16(2)19(15)22-13-5-12-20-14-17-8-10-18(21-3)11-9-17/h4,6-11,20H,5,12-14H2,1-3H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432082
PNG
(US10577308, Compound 553)
Show SMILES CC(NCCCOc1c(C)cccc1C)c1ccccc1
Show InChI InChI=1S/C19H25NO/c1-15-9-7-10-16(2)19(15)21-14-8-13-20-17(3)18-11-5-4-6-12-18/h4-7,9-12,17,20H,8,13-14H2,1-3H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432070
PNG
(US10577308, Compound 525)
Show SMILES COc1cccc(CNCCCOc2c(C)cccc2C)c1
Show InChI InChI=1S/C19H25NO2/c1-15-7-4-8-16(2)19(15)22-12-6-11-20-14-17-9-5-10-18(13-17)21-3/h4-5,7-10,13,20H,6,11-12,14H2,1-3H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432059
PNG
(US10577308, Compound 519)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccc(cc1)C#N
Show InChI InChI=1S/C19H22N2O/c1-15-5-3-6-16(2)19(15)22-12-4-11-21-14-18-9-7-17(13-20)8-10-18/h3,5-10,21H,4,11-12,14H2,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432059
PNG
(US10577308, Compound 519)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccc(cc1)C#N
Show InChI InChI=1S/C19H22N2O/c1-15-5-3-6-16(2)19(15)22-12-4-11-21-14-18-9-7-17(13-20)8-10-18/h3,5-10,21H,4,11-12,14H2,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432070
PNG
(US10577308, Compound 525)
Show SMILES COc1cccc(CNCCCOc2c(C)cccc2C)c1
Show InChI InChI=1S/C19H25NO2/c1-15-7-4-8-16(2)19(15)22-12-6-11-20-14-17-9-5-10-18(13-17)21-3/h4-5,7-10,13,20H,6,11-12,14H2,1-3H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432076
PNG
(US10577308, Compound 523)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccn1
Show InChI InChI=1S/C17H22N2O/c1-14-7-5-8-15(2)17(14)20-12-6-10-18-13-16-9-3-4-11-19-16/h3-5,7-9,11,18H,6,10,12-13H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 2 alpha subunit


(Homo sapiens (Human))
BDBM432071
PNG
(US10577308, Compound 533)
Show SMILES Cc1cccc(C)c1OCCCNCc1cccc(c1)C#N
Show InChI InChI=1S/C19H22N2O/c1-15-6-3-7-16(2)19(15)22-11-5-10-21-14-18-9-4-8-17(12-18)13-20/h3-4,6-9,12,21H,5,10-11,14H2,1-2H3
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antibodypedia
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
Sodium channel protein type 8 subunit alpha


(Homo sapiens (Human))
BDBM432058
PNG
(US10577308, Compound 518)
Show SMILES Cc1cccc(C)c1OCCCNCc1ccccc1
Show InChI InChI=1S/C18H23NO/c1-15-8-6-9-16(2)18(15)20-13-7-12-19-14-17-10-4-3-5-11-17/h3-6,8-11,19H,7,12-14H2,1-2H3
PDB

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n/an/a 2.00E+3n/an/an/an/an/an/a



The Florey Institute; The University of Melbourne

US Patent


Assay Description
Test Protocol for Determining the Potency of Compounds on Nav1.2 and Nav1.6 Subtypes of Voltage-Gated Sodium Ion Channels Expressed in Mammalian Cell...


US Patent US10577308 (2020)


BindingDB Entry DOI: 10.7270/Q2CZ39JQ
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%