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Patent code US10577336

Compile Data Set for Download or QSAR
Found 169 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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89.2n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19 | US10577336, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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194n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95 | US10577336, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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218n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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522n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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8.62E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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8.62E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95 | US10577336, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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8.69E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19 | US10577336, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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8.71E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19 | US10577336, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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9.01E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95 | US10577336, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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9.48E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19 | US10577336, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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9.63E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95 | US10577336, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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9.63E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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9.75E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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9.75E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95 | US10577336, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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9.77E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19 | US10577336, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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9.86E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275968
PNG
(US10071974, Example 79 | US10577336, Example 79)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21ClN4O2/c1-16(2,19-15(22)12-9-18-7-8-23-12)14-10-5-4-6-11(17)13(10)21(3)20-14/h4-6,12,18H,7-9H2,1-3H3,(H,19,22)/t12-/m0/s1
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n/an/an/an/a 2.20n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275969
PNG
(US10071974, Example 80 | US10071974, Example 81 | ...)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23ClN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)
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n/an/an/an/a 152n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275969
PNG
(US10071974, Example 80 | US10071974, Example 81 | ...)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23ClN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95 | US10577336, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275991
PNG
(US10071974, Example 102 | US10577336, Example 102)
Show SMILES Cc1cccn2c(ncc12)C1(CCC1)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H22N4O2/c1-12-4-2-8-21-13(12)10-19-16(21)17(5-3-6-17)20-15(22)14-11-18-7-9-23-14/h2,4,8,10,14,18H,3,5-7,9,11H2,1H3,(H,20,22)/t14-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276017
PNG
(US10071974, Example 128 | US10071974, Example 129 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-8-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-10-19-7-9-24-11-14/h5-6,8,14,19H,7,9-11H2,1-4H3,(H,21,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276030
PNG
(US10071974, Example 141 | US10071974, Example 142 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-9-21-13(12)11-19-16(21)17(2,3)20-15(22)14-6-7-18-8-10-23-14/h4-5,9,11,14,18H,6-8,10H2,1-3H3,(H,20,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276033
PNG
(US10071974, Example 144 | US10071974, Example 145 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-6-4-8-21-13(12)10-19-16(21)17(2,3)20-15(22)14-11-18-7-5-9-23-14/h4,6,8,10,14,18H,5,7,9,11H2,1-3H3,(H,20,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276036
PNG
(US10071974, Example 147 | US10071974, Example 148 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C18H26N4O2/c1-12-7-5-9-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-11-19-8-6-10-24-14/h5,7,9,14,19H,6,8,10-11H2,1-4H3,(H,21,23)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275896
PNG
(US10071974, Example 7 | US10577336, Example 7)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)C1CCCCC1
Show InChI InChI=1S/C14H26N2O2/c1-14(2,11-6-4-3-5-7-11)16-13(17)12-10-15-8-9-18-12/h11-12,15H,3-10H2,1-2H3,(H,16,17)/t12-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275895
PNG
(US10071974, Example 12 | US10071974, Example 6 | U...)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1cccc2ccccc12
Show InChI InChI=1S/C18H22N2O2/c1-18(2,20-17(21)16-12-19-10-11-22-16)15-9-5-7-13-6-3-4-8-14(13)15/h3-9,16,19H,10-12H2,1-2H3,(H,20,21)/t16-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275903
PNG
(US10071974, Example 14 | US10577336, Example 14)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1nc2ccc(Cl)cc2[nH]1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275905
PNG
(US10071974, Example 16 | US10071974, Example 17 | ...)
Show SMILES CC(C)(COc1nccc2ccccc12)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O3/c1-19(2,22-17(23)15-11-20-9-10-24-12-15)13-25-18-16-6-4-3-5-14(16)7-8-21-18/h3-8,15,20H,9-13H2,1-2H3,(H,22,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275947
PNG
(US10071974, Example 58 | US10071974, Example 59 | ...)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)C1CNCCOC1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275954
PNG
(US10071974, Example 65 | US10071974, Example 66 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-9-18-7-4-8-22-12)14-10-5-3-6-11(17)13(10)23-20-14/h3,5-6,12,18H,4,7-9H2,1-2H3,(H,19,21)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275957
PNG
(US10071974, Example 68 | US10071974, Example 69 | ...)
Show SMILES CC(C)(NC(=O)C1CCNCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-6-7-18-8-9-22-12)14-10-4-3-5-11(17)13(10)23-20-14/h3-5,12,18H,6-9H2,1-2H3,(H,19,21)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275964
PNG
(US10071974, Example 75 | US10577336, Example 75)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-16(2,19-15(22)12-9-18-7-8-23-12)14-10-5-4-6-11(17)13(10)21(3)20-14/h4-6,12,18H,7-9H2,1-3H3,(H,19,22)/t12-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275985
PNG
(US10071974, Example 96 | US10577336, Example 96)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1ncc2c(Cl)cccn12
Show InChI InChI=1S/C15H19ClN4O2/c1-15(2,19-13(21)12-9-17-5-7-22-12)14-18-8-11-10(16)4-3-6-20(11)14/h3-4,6,8,12,17H,5,7,9H2,1-2H3,(H,19,21)/t12-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275993
PNG
(US10071974, Example 104 | US10577336, Example 104)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C19H26N4O2/c1-12-5-4-9-23-16(12)15(13-6-7-13)21-18(23)19(2,3)22-17(24)14-11-20-8-10-25-14/h4-5,9,13-14,20H,6-8,10-11H2,1-3H3,(H,22,24)/t14-/m0/s1
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n/an/an/an/a 73.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276001
PNG
(US10071974, Example 112 | US10071974, Example 113 ...)
Show SMILES CC(C)CC(C)(NC(=O)[C@@H]1CNCCO1)c1ncc2c(C)cccn12
Show InChI InChI=1S/C19H28N4O2/c1-13(2)10-19(4,22-17(24)16-12-20-7-9-25-16)18-21-11-15-14(3)6-5-8-23(15)18/h5-6,8,11,13,16,20H,7,9-10,12H2,1-4H3,(H,22,24)/t16-,19?/m0/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276017
PNG
(US10071974, Example 128 | US10071974, Example 129 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-8-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-10-19-7-9-24-11-14/h5-6,8,14,19H,7,9-11H2,1-4H3,(H,21,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276022
PNG
(US10071974, Example 133 | US10071974, Example 134 ...)
Show SMILES Cc1nc(c2cccc(C)c2n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H26N4O2/c1-12-6-5-7-15-16(12)21-13(2)22-17(15)19(3,4)23-18(24)14-10-20-8-9-25-11-14/h5-7,14,20H,8-11H2,1-4H3,(H,23,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276022
PNG
(US10071974, Example 133 | US10071974, Example 134 ...)
Show SMILES Cc1nc(c2cccc(C)c2n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H26N4O2/c1-12-6-5-7-15-16(12)21-13(2)22-17(15)19(3,4)23-18(24)14-10-20-8-9-25-11-14/h5-7,14,20H,8-11H2,1-4H3,(H,23,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276030
PNG
(US10071974, Example 141 | US10071974, Example 142 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-9-21-13(12)11-19-16(21)17(2,3)20-15(22)14-6-7-18-8-10-23-14/h4-5,9,11,14,18H,6-8,10H2,1-3H3,(H,20,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432107
PNG
(US10577336, Example 5)
Show SMILES Cc1cccn2c(ncc12)C1(CC1)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H22N4O2/c1-12-3-2-7-21-14(12)10-19-16(21)17(4-5-17)20-15(22)13-9-18-6-8-23-11-13/h2-3,7,10,13,18H,4-6,8-9,11H2,1H3,(H,20,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19 | US10577336, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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n/an/an/an/a 13.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275919
PNG
(US10071974, Example 30 | US10577336, Example 30)
Show SMILES Cn1nc(c2ccc(F)cc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-16(2,19-15(22)13-9-18-6-7-23-13)14-11-5-4-10(17)8-12(11)21(3)20-14/h4-5,8,13,18H,6-7,9H2,1-3H3,(H,19,22)/t13-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275928
PNG
(US10071974, Example 39 | US10577336, Example 39)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C18H23N3O2/c1-12-13-6-4-5-7-14(13)15(10-20-12)18(2,3)21-17(22)16-11-19-8-9-23-16/h4-7,10,16,19H,8-9,11H2,1-3H3,(H,21,22)/t16-/m1/s1
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n/an/an/an/a 180n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275936
PNG
(US10071974, Example 47 | US10071974, Example 48 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-11-14-7-4-5-8-15(14)17(21-13)19(2,3)22-18(23)16-12-20-9-6-10-24-16/h4-5,7-8,11,16,20H,6,9-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 25.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275943
PNG
(US10071974, Example 54 | US10071974, Example 55 | ...)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23N3O3/c1-11-5-4-6-13-14(11)23-20-15(13)17(2,3)19-16(21)12-9-18-7-8-22-10-12/h4-6,12,18H,7-10H2,1-3H3,(H,19,21)
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n/an/an/an/a 738n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275947
PNG
(US10071974, Example 58 | US10071974, Example 59 | ...)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)C1CNCCOC1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275950
PNG
(US10071974, Example 61 | US10577336, Example 61)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C15H18FN3O3/c1-15(2,18-14(20)11-8-17-6-7-21-11)13-9-4-3-5-10(16)12(9)22-19-13/h3-5,11,17H,6-8H2,1-2H3,(H,18,20)/t11-/m0/s1
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n/an/an/an/a 147n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275954
PNG
(US10071974, Example 65 | US10071974, Example 66 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-9-18-7-4-8-22-12)14-10-5-3-6-11(17)13(10)23-20-14/h3,5-6,12,18H,4,7-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 624n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432176
PNG
(US10577336, Example 74)
Show SMILES CC(C)(N(O)C(=O)C1CNCCOC1)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C16H20ClN3O4/c1-16(2,14-11-4-3-5-12(17)13(11)24-19-14)20(22)15(21)10-8-18-6-7-23-9-10/h3-5,10,18,22H,6-9H2,1-2H3
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n/an/an/an/a 1.19E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275969
PNG
(US10071974, Example 80 | US10071974, Example 81 | ...)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23ClN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275972
PNG
(US10071974, Example 83 | US10577336, Example 83)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-11-6-5-7-12-14(11)21(4)20-15(12)17(2,3)19-16(22)13-10-18-8-9-23-13/h5-7,13,18H,8-10H2,1-4H3,(H,19,22)/t13-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275976
PNG
(US10071974, Example 87 | US10577336, Example 87)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1n[nH]c2c(F)cccc12
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276003
PNG
(US10071974, Example 114 | US10071974, Example 115 ...)
Show SMILES Cc1cccn2c(ncc12)C1(CCOC1)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H22N4O3/c1-12-3-2-6-21-13(12)9-19-16(21)17(4-7-23-11-17)20-15(22)14-10-18-5-8-24-14/h2-3,6,9,14,18H,4-5,7-8,10-11H2,1H3,(H,20,22)/t14-,17?/m0/s1
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n/an/an/an/a 294n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276017
PNG
(US10071974, Example 128 | US10071974, Example 129 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-8-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-10-19-7-9-24-11-14/h5-6,8,14,19H,7,9-11H2,1-4H3,(H,21,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276020
PNG
(US10071974, Example 131 | US10071974, Example 132 ...)
Show SMILES Cc1cccn2c(ncc12)C1(CCC1)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H24N4O2/c1-13-4-2-8-22-15(13)11-20-17(22)18(5-3-6-18)21-16(23)14-10-19-7-9-24-12-14/h2,4,8,11,14,19H,3,5-7,9-10,12H2,1H3,(H,21,23)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276030
PNG
(US10071974, Example 141 | US10071974, Example 142 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-9-21-13(12)11-19-16(21)17(2,3)20-15(22)14-6-7-18-8-10-23-14/h4-5,9,11,14,18H,6-8,10H2,1-3H3,(H,20,22)
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n/an/an/an/a 77.6n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276033
PNG
(US10071974, Example 144 | US10071974, Example 145 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-6-4-8-21-13(12)10-19-16(21)17(2,3)20-15(22)14-11-18-7-5-9-23-14/h4,6,8,10,14,18H,5,7,9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 71.8n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275895
PNG
(US10071974, Example 12 | US10071974, Example 6 | U...)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1cccc2ccccc12
Show InChI InChI=1S/C18H22N2O2/c1-18(2,20-17(21)16-12-19-10-11-22-16)15-9-5-7-13-6-3-4-8-14(13)15/h3-9,16,19H,10-12H2,1-2H3,(H,20,21)/t16-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275915
PNG
(US10071974, Example 26 | US10071974, Example 27 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-8-9-18-10-11-23-14)15-12-6-4-5-7-13(12)21(3)20-15/h4-7,14,18H,8-11H2,1-3H3,(H,19,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275920
PNG
(US10071974, Example 31 | US10577336, Example 31)
Show SMILES Cn1nc(c2cccc(c12)C(F)(F)F)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H21F3N4O2/c1-16(2,22-15(25)12-9-21-7-8-26-12)14-10-5-4-6-11(17(18,19)20)13(10)24(3)23-14/h4-6,12,21H,7-9H2,1-3H3,(H,22,25)/t12-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275933
PNG
(US10071974, Example 44 | US10071974, Example 45 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-10-14-6-4-5-7-16(14)17(21-13)19(2,3)22-18(23)15-11-20-8-9-24-12-15/h4-7,10,15,20H,8-9,11-12H2,1-3H3,(H,22,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275939
PNG
(US10071974, Example 50 | US10071974, Example 51 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-12-14-6-4-5-7-15(14)17(21-13)19(2,3)22-18(23)16-8-9-20-10-11-24-16/h4-7,12,16,20H,8-11H2,1-3H3,(H,22,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275960
PNG
(US10071974, Example 71 | US10577336, Example 71)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C15H18ClN3O3/c1-15(2,18-14(20)11-8-17-6-7-21-11)13-9-4-3-5-10(16)12(9)22-19-13/h3-5,11,17H,6-8H2,1-2H3,(H,18,20)/t11-/m0/s1
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n/an/an/an/a 35.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275973
PNG
(US10071974, Example 84 | US10071974, Example 85 | ...)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-7-14-15(12)22(4)21-16(14)18(2,3)20-17(23)13-10-19-8-9-24-11-13/h5-7,13,19H,8-11H2,1-4H3,(H,20,23)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275977
PNG
(US10071974, Example 88 | US10071974, Example 89 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(F)cccc12
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275980
PNG
(US10071974, Example 91 | US10577336, Example 91)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1n[nH]c2c(Cl)cccc12
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275981
PNG
(US10071974, Example 92 | US10071974, Example 93 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(Cl)cccc12
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275988
PNG
(US10071974, Example 99 | US10577336, Example 99)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O3/c1-16(2,19-14(21)13-10-17-6-8-23-13)15-18-9-11-12(22-3)5-4-7-20(11)15/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275989
PNG
(US10071974, Example 100 | US10577336, Example 100)
Show SMILES Cc1cc(F)cn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-10-6-11(17)9-21-12(10)7-19-15(21)16(2,3)20-14(22)13-8-18-4-5-23-13/h6-7,9,13,18H,4-5,8H2,1-3H3,(H,20,22)/t13-/m0/s1
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n/an/an/an/a 103n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275995
PNG
(US10071974, Example 106 | US10577336, Example 106)
Show SMILES Cc1nc2ccccn2c1C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-14(20-8-5-4-6-13(20)18-11)16(2,3)19-15(21)12-10-17-7-9-22-12/h4-6,8,12,17H,7,9-10H2,1-3H3,(H,19,21)/t12-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275997
PNG
(US10071974, Example 108 | US10577336, Example 108)
Show SMILES Cc1cccn2c(cnc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-13(10-18-14(11)20)16(2,3)19-15(21)12-9-17-6-8-22-12/h4-5,7,10,12,17H,6,8-9H2,1-3H3,(H,19,21)/t12-/m0/s1
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n/an/an/an/a 58.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276010
PNG
(US10071974, Example 121 | US10071974, Example 122 ...)
Show SMILES Cc1nc(n2cccc(F)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-11-14-13(18)5-4-7-22(14)16(20-11)17(2,3)21-15(23)12-9-19-6-8-24-10-12/h4-5,7,12,19H,6,8-10H2,1-3H3,(H,21,23)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276020
PNG
(US10071974, Example 131 | US10071974, Example 132 ...)
Show SMILES Cc1cccn2c(ncc12)C1(CCC1)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H24N4O2/c1-13-4-2-8-22-15(13)11-20-17(22)18(5-3-6-18)21-16(23)14-10-19-7-9-24-12-14/h2,4,8,11,14,19H,3,5-7,9-10,12H2,1H3,(H,21,23)
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n/an/an/an/a 19n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275789
PNG
(US10071974, Example 1 | US10577336, Example 1)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1cccc2ccccc12
Show InChI InChI=1S/C19H24N2O2/c1-19(2,21-18(22)15-12-20-10-11-23-13-15)17-9-5-7-14-6-3-4-8-16(14)17/h3-9,15,20H,10-13H2,1-2H3,(H,21,22)
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n/an/an/an/a 4.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275888
PNG
(US10071974, Example 2 | US10577336, Example 2)
Show SMILES Cc1cc2cccnc2c(n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H24N4O2/c1-12-9-13-5-4-6-20-15(13)16(21-12)18(2,3)22-17(23)14-10-19-7-8-24-11-14/h4-6,9,14,19H,7-8,10-11H2,1-3H3,(H,22,23)
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n/an/an/an/a 90.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275902
PNG
(US10071974, Example 13 | US10577336, Example 13)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1nc2ccc(Cl)cc2[nH]1
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n/an/an/an/a 356n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 192n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 36.2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275922
PNG
(US10071974, Example 33 | US10071974, Example 34 | ...)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-6-15-14(10-19-21(12)15)17(2,3)20-16(22)13-9-18-7-8-23-11-13/h4-6,10,13,18H,7-9,11H2,1-3H3,(H,20,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275936
PNG
(US10071974, Example 47 | US10071974, Example 48 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-11-14-7-4-5-8-15(14)17(21-13)19(2,3)22-18(23)16-12-20-9-6-10-24-16/h4-5,7-8,11,16,20H,6,9-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 988n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275943
PNG
(US10071974, Example 54 | US10071974, Example 55 | ...)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23N3O3/c1-11-5-4-6-13-14(11)23-20-15(13)17(2,3)19-16(21)12-9-18-7-8-22-10-12/h4-6,12,18H,7-10H2,1-3H3,(H,19,21)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275951
PNG
(US10071974, Example 62 | US10071974, Example 63 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)10-8-18-6-7-22-9-10)14-11-4-3-5-12(17)13(11)23-20-14/h3-5,10,18H,6-9H2,1-2H3,(H,19,21)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275957
PNG
(US10071974, Example 68 | US10071974, Example 69 | ...)
Show SMILES CC(C)(NC(=O)C1CCNCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-6-7-18-8-9-22-12)14-10-4-3-5-11(17)13(10)23-20-14/h3-5,12,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 544n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432174
PNG
(US10577336, Example 72 | US10577336, Example 73)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C16H20ClN3O3/c1-16(2,19-15(21)10-8-18-6-7-22-9-10)14-11-4-3-5-12(17)13(11)23-20-14/h3-5,10,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 17.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432178
PNG
(US10577336, Example 76)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)
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n/an/an/an/a 10n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275990
PNG
(US10071974, Example 101 | US10071974, Example 103 ...)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1nc(C2CC2)c2c(F)cccn12
Show InChI InChI=1S/C18H23FN4O2/c1-18(2,22-16(24)13-10-20-7-9-25-13)17-21-14(11-5-6-11)15-12(19)4-3-8-23(15)17/h3-4,8,11,13,20H,5-7,9-10H2,1-2H3,(H,22,24)/t13-/m0/s1
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n/an/an/an/a 6.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275990
PNG
(US10071974, Example 101 | US10071974, Example 103 ...)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1nc(C2CC2)c2c(F)cccn12
Show InChI InChI=1S/C18H23FN4O2/c1-18(2,22-16(24)13-10-20-7-9-25-13)17-21-14(11-5-6-11)15-12(19)4-3-8-23(15)17/h3-4,8,11,13,20H,5-7,9-10H2,1-2H3,(H,22,24)/t13-/m0/s1
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n/an/an/an/a 60.7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275998
PNG
(US10071974, Example 109 | US10577336, Example 109)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H23N3O2/c1-12-5-4-9-20-13(12)6-7-15(20)17(2,3)19-16(21)14-11-18-8-10-22-14/h4-7,9,14,18H,8,10-11H2,1-3H3,(H,19,21)/t14-/m0/s1
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n/an/an/an/a 3.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275999
PNG
(US10071974, Example 110 | US10071974, Example 111 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(NC(=O)[C@@H]1CNCCO1)C1CC1
Show InChI InChI=1S/C18H24N4O2/c1-12-4-3-8-22-14(12)10-20-17(22)18(2,13-5-6-13)21-16(23)15-11-19-7-9-24-15/h3-4,8,10,13,15,19H,5-7,9,11H2,1-2H3,(H,21,23)/t15-,18?/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276003
PNG
(US10071974, Example 114 | US10071974, Example 115 ...)
Show SMILES Cc1cccn2c(ncc12)C1(CCOC1)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H22N4O3/c1-12-3-2-6-21-13(12)9-19-16(21)17(4-7-23-11-17)20-15(22)14-10-18-5-8-24-14/h2-3,6,9,14,18H,4-5,7-8,10-11H2,1H3,(H,20,22)/t14-,17?/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276008
PNG
(US10071974, Example 119 | US10071974, Example 120 ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1ncc2c(Cl)cccn12
Show InChI InChI=1S/C16H21ClN4O2/c1-16(2,20-14(22)11-8-18-5-7-23-10-11)15-19-9-13-12(17)4-3-6-21(13)15/h3-4,6,9,11,18H,5,7-8,10H2,1-2H3,(H,20,22)
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n/an/an/an/a 5.90n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276015
PNG
(US10071974, Example 126 | US10071974, Example 127 ...)
Show SMILES Cc1cc(F)cn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-11-6-13(18)9-22-14(11)8-20-16(22)17(2,3)21-15(23)12-7-19-4-5-24-10-12/h6,8-9,12,19H,4-5,7,10H2,1-3H3,(H,21,23)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276024
PNG
(US10071974, Example 135 | US10071974, Example 136 ...)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H25N3O2/c1-13-5-4-9-21-15(13)6-7-16(21)18(2,3)20-17(22)14-11-19-8-10-23-12-14/h4-7,9,14,19H,8,10-12H2,1-3H3,(H,20,22)
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n/an/an/an/a 8.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276027
PNG
(US10071974, Example 138 | US10071974, Example 139 ...)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C20H28N4O2/c1-13-5-4-9-24-17(13)16(14-6-7-14)22-19(24)20(2,3)23-18(25)15-11-21-8-10-26-12-15/h4-5,9,14-15,21H,6-8,10-12H2,1-3H3,(H,23,25)
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n/an/an/an/a 22.2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276033
PNG
(US10071974, Example 144 | US10071974, Example 145 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-6-4-8-21-13(12)10-19-16(21)17(2,3)20-15(22)14-11-18-7-5-9-23-14/h4,6,8,10,14,18H,5,7,9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276036
PNG
(US10071974, Example 147 | US10071974, Example 148 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C18H26N4O2/c1-12-7-5-9-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-11-19-8-6-10-24-14/h5,7,9,14,19H,6,8,10-11H2,1-4H3,(H,21,23)
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n/an/an/an/a 93n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275893
PNG
(US10071974, Example 4 | US10577336, Example 4)
Show SMILES CC(C)(COc1cnccc1C(F)(F)F)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C16H22F3N3O3/c1-15(2,22-14(23)11-7-21-5-6-24-9-11)10-25-13-8-20-4-3-12(13)16(17,18)19/h3-4,8,11,21H,5-7,9-10H2,1-2H3,(H,22,23)
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n/an/an/an/a 272n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275915
PNG
(US10071974, Example 26 | US10071974, Example 27 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-8-9-18-10-11-23-14)15-12-6-4-5-7-13(12)21(3)20-15/h4-7,14,18H,8-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 61.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275922
PNG
(US10071974, Example 33 | US10071974, Example 34 | ...)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-6-15-14(10-19-21(12)15)17(2,3)20-16(22)13-9-18-7-8-23-11-13/h4-6,10,13,18H,7-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 2.87E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275929
PNG
(US10071974, Example 40 | US10071974, Example 41 | ...)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-15-6-4-5-7-16(15)17(11-21-13)19(2,3)22-18(23)14-10-20-8-9-24-12-14/h4-7,11,14,20H,8-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 415n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275939
PNG
(US10071974, Example 50 | US10071974, Example 51 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-12-14-6-4-5-7-15(14)17(21-13)19(2,3)22-18(23)16-8-9-20-10-11-24-16/h4-7,12,16,20H,8-11H2,1-3H3,(H,22,23)
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n/an/an/an/a 105n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275947
PNG
(US10071974, Example 58 | US10071974, Example 59 | ...)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)C1CNCCOC1
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n/an/an/an/a 1.07E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275966
PNG
(US10071974, Example 77 | US10577336, Example 77)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)[C@H]1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)/t11-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275967
PNG
(US10071974, Example 78 | US10577336, Example 78)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)[C@@H]1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)/t11-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275973
PNG
(US10071974, Example 84 | US10071974, Example 85 | ...)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-7-14-15(12)22(4)21-16(14)18(2,3)20-17(23)13-10-19-8-9-24-11-13/h5-7,13,19H,8-11H2,1-4H3,(H,20,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276008
PNG
(US10071974, Example 119 | US10071974, Example 120 ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1ncc2c(Cl)cccn12
Show InChI InChI=1S/C16H21ClN4O2/c1-16(2,20-14(22)11-8-18-5-7-23-10-11)15-19-9-13-12(17)4-3-6-21(13)15/h3-4,6,9,11,18H,5,7-8,10H2,1-2H3,(H,20,22)
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n/an/an/an/a 73.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276012
PNG
(US10071974, Example 123 | US10071974, Example 124 ...)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O3/c1-17(2,20-15(22)12-9-18-6-8-24-11-12)16-19-10-13-14(23-3)5-4-7-21(13)16/h4-5,7,10,12,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 32.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276024
PNG
(US10071974, Example 135 | US10071974, Example 136 ...)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H25N3O2/c1-13-5-4-9-21-15(13)6-7-16(21)18(2,3)20-17(22)14-11-19-8-10-23-12-14/h4-7,9,14,19H,8,10-12H2,1-3H3,(H,20,22)
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n/an/an/an/a 1.43E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276036
PNG
(US10071974, Example 147 | US10071974, Example 148 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C18H26N4O2/c1-12-7-5-9-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-11-19-8-6-10-24-14/h5,7,9,14,19H,6,8,10-11H2,1-4H3,(H,21,23)
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n/an/an/an/a 185n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275892
PNG
(US10071974, Example 3 | US10577336, Example 3)
Show SMILES C[C@H](NC(=O)C1CNCCOC1)c1cccc2ccccc12
Show InChI InChI=1S/C18H22N2O2/c1-13(20-18(21)15-11-19-9-10-22-12-15)16-8-4-6-14-5-2-3-7-17(14)16/h2-8,13,15,19H,9-12H2,1H3,(H,20,21)/t13-,15?/m0/s1
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n/an/an/an/a 18n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275899
PNG
(US10071974, Example 10 | US10577336, Example 10)
Show SMILES C[C@H](NC(=O)[C@@H]1CNCCO1)c1cccc2ccccc12
Show InChI InChI=1S/C17H20N2O2/c1-12(19-17(20)16-11-18-9-10-21-16)14-8-4-6-13-5-2-3-7-15(13)14/h2-8,12,16,18H,9-11H2,1H3,(H,19,20)/t12-,16-/m0/s1
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n/an/an/an/a 51.2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275932
PNG
(US10071974, Example 43 | US10577336, Example 43)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C18H23N3O2/c1-12-10-13-6-4-5-7-14(13)16(20-12)18(2,3)21-17(22)15-11-19-8-9-23-15/h4-7,10,15,19H,8-9,11H2,1-3H3,(H,21,22)/t15-/m0/s1
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n/an/an/an/a 6.60n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275933
PNG
(US10071974, Example 44 | US10071974, Example 45 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-10-14-6-4-5-7-16(14)17(21-13)19(2,3)22-18(23)15-11-20-8-9-24-12-15/h4-7,10,15,20H,8-9,11-12H2,1-3H3,(H,22,23)
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n/an/an/an/a 3.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275942
PNG
(US10071974, Example 53 | US10577336, Example 53)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21N3O3/c1-10-5-4-6-11-13(10)22-19-14(11)16(2,3)18-15(20)12-9-17-7-8-21-12/h4-6,12,17H,7-9H2,1-3H3,(H,18,20)/t12-/m0/s1
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n/an/an/an/a 13.6n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275946
PNG
(US10071974, Example 57 | US10577336, Example 57)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
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n/an/an/an/a 2.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275957
PNG
(US10071974, Example 68 | US10071974, Example 69 | ...)
Show SMILES CC(C)(NC(=O)C1CCNCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-6-7-18-8-9-22-12)14-10-4-3-5-11(17)13(10)23-20-14/h3-5,12,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 628n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275973
PNG
(US10071974, Example 84 | US10071974, Example 85 | ...)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-7-14-15(12)22(4)21-16(14)18(2,3)20-17(23)13-10-19-8-9-24-11-13/h5-7,13,19H,8-11H2,1-4H3,(H,20,23)
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n/an/an/an/a 4.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275977
PNG
(US10071974, Example 88 | US10071974, Example 89 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(F)cccc12
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n/an/an/an/a 670n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275981
PNG
(US10071974, Example 92 | US10071974, Example 93 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(Cl)cccc12
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275986
PNG
(US10071974, Example 97 | US10577336, Example 97)
Show SMILES Cc1cccn2c(ncc12)C1(CC1)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H20N4O2/c1-11-3-2-7-20-12(11)9-18-15(20)16(4-5-16)19-14(21)13-10-17-6-8-22-13/h2-3,7,9,13,17H,4-6,8,10H2,1H3,(H,19,21)/t13-/m0/s1
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n/an/an/an/a 40.8n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432200
PNG
(US10577336, Example 98)
Show SMILES Cc1nc(n2cccc(F)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-10-13-11(17)5-4-7-21(13)15(19-10)16(2,3)20-14(22)12-9-18-6-8-23-12/h4-5,7,12,18H,6,8-9H2,1-3H3,(H,20,22)/t12-/m0/s1
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n/an/an/an/a 85.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275996
PNG
(US10071974, Example 107 | US10577336, Example 107)
Show SMILES Cc1nc(c2cccc(C)c2n1)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C18H24N4O2/c1-11-6-5-7-13-15(11)20-12(2)21-16(13)18(3,4)22-17(23)14-10-19-8-9-24-14/h5-7,14,19H,8-10H2,1-4H3,(H,22,23)/t14-/m0/s1
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n/an/an/an/a 51.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276005
PNG
(US10071974, Example 116 | US10071974, Example 117 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-7-21-14(12)10-19-16(21)17(2,3)20-15(22)13-9-18-6-8-23-11-13/h4-5,7,10,13,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 86.8n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276012
PNG
(US10071974, Example 123 | US10071974, Example 124 ...)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O3/c1-17(2,20-15(22)12-9-18-6-8-24-11-12)16-19-10-13-14(23-3)5-4-7-21(13)16/h4-5,7,10,12,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276012
PNG
(US10071974, Example 123 | US10071974, Example 124 ...)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O3/c1-17(2,20-15(22)12-9-18-6-8-24-11-12)16-19-10-13-14(23-3)5-4-7-21(13)16/h4-5,7,10,12,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 16.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276015
PNG
(US10071974, Example 126 | US10071974, Example 127 ...)
Show SMILES Cc1cc(F)cn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-11-6-13(18)9-22-14(11)8-20-16(22)17(2,3)21-15(23)12-7-19-4-5-24-10-12/h6,8-9,12,19H,4-5,7,10H2,1-3H3,(H,21,23)
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n/an/an/an/a 46n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432240
PNG
(US10577336, Example 138)
Show SMILES Cc1cccn2c(cc(C3CC3)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C21H29N3O2/c1-14-5-4-9-24-18(11-17(19(14)24)15-6-7-15)21(2,3)23-20(25)16-12-22-8-10-26-13-16/h4-5,9,11,15-16,22H,6-8,10,12-13H2,1-3H3,(H,23,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432110
PNG
(US10577336, Example 8)
Show SMILES CC(C)(NC(=O)[C@H]1CNCCO1)c1ccnc2ccccc12
Show InChI InChI=1S/C17H21N3O2/c1-17(2,20-16(21)15-11-18-9-10-22-15)13-7-8-19-14-6-4-3-5-12(13)14/h3-8,15,18H,9-11H2,1-2H3,(H,20,21)/t15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275898
PNG
(US10071974, Example 9 | US10577336, Example 9)
Show SMILES CC(C)(COc1cnccc1C(F)(F)F)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C15H20F3N3O3/c1-14(2,21-13(22)12-8-20-5-6-23-12)9-24-11-7-19-4-3-10(11)15(16,17)18/h3-4,7,12,20H,5-6,8-9H2,1-2H3,(H,21,22)/t12-/m0/s1
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n/an/an/an/a 190n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275904
PNG
(US10071974, Example 15 | US10577336, Example 15)
Show SMILES Cc1ccccc1OCC(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H24N2O3/c1-12-6-4-5-7-13(12)21-11-16(2,3)18-15(19)14-10-17-8-9-20-14/h4-7,14,17H,8-11H2,1-3H3,(H,18,19)/t14-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275905
PNG
(US10071974, Example 16 | US10071974, Example 17 | ...)
Show SMILES CC(C)(COc1nccc2ccccc12)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O3/c1-19(2,22-17(23)15-11-20-9-10-24-12-15)13-25-18-16-6-4-3-5-14(16)7-8-21-18/h3-8,15,20H,9-13H2,1-2H3,(H,22,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275915
PNG
(US10071974, Example 26 | US10071974, Example 27 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-8-9-18-10-11-23-14)15-12-6-4-5-7-13(12)21(3)20-15/h4-7,14,18H,8-11H2,1-3H3,(H,19,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275926
PNG
(US10071974, Example 37 | US10577336, Example 37)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H24N4O2/c1-12-14-6-4-5-7-15(14)16(22-21-12)18(2,3)20-17(23)13-10-19-8-9-24-11-13/h4-7,13,19H,8-11H2,1-3H3,(H,20,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432140
PNG
(US10577336, Example 38)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C18H23N3O2/c1-12-13-6-4-5-7-14(13)15(10-20-12)18(2,3)21-17(22)16-11-19-8-9-23-16/h4-7,10,16,19H,8-9,11H2,1-3H3,(H,21,22)/t16-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275933
PNG
(US10071974, Example 44 | US10071974, Example 45 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-10-14-6-4-5-7-16(14)17(21-13)19(2,3)22-18(23)15-11-20-8-9-24-12-15/h4-7,10,15,20H,8-9,11-12H2,1-3H3,(H,22,23)
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n/an/an/an/a 795n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275939
PNG
(US10071974, Example 50 | US10071974, Example 51 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-12-14-6-4-5-7-15(14)17(21-13)19(2,3)22-18(23)16-8-9-20-10-11-24-16/h4-7,12,16,20H,8-11H2,1-3H3,(H,22,23)
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n/an/an/an/a 48.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275943
PNG
(US10071974, Example 54 | US10071974, Example 55 | ...)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23N3O3/c1-11-5-4-6-13-14(11)23-20-15(13)17(2,3)19-16(21)12-9-18-7-8-22-10-12/h4-6,12,18H,7-10H2,1-3H3,(H,19,21)
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n/an/an/an/a 2.90n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM432174
PNG
(US10577336, Example 72 | US10577336, Example 73)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C16H20ClN3O3/c1-16(2,19-15(21)10-8-18-6-7-22-9-10)14-11-4-3-5-12(17)13(11)23-20-14/h3-5,10,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 8.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275977
PNG
(US10071974, Example 88 | US10071974, Example 89 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(F)cccc12
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275981
PNG
(US10071974, Example 92 | US10071974, Example 93 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(Cl)cccc12
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275994
PNG
(US10071974, Example 105 | US10577336, Example 105)
Show SMILES Cc1cccn2c(nnc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C15H21N5O2/c1-10-5-4-7-20-12(10)18-19-14(20)15(2,3)17-13(21)11-9-16-6-8-22-11/h4-5,7,11,16H,6,8-9H2,1-3H3,(H,17,21)/t11-/m0/s1
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n/an/an/an/a 596n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275999
PNG
(US10071974, Example 110 | US10071974, Example 111 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(NC(=O)[C@@H]1CNCCO1)C1CC1
Show InChI InChI=1S/C18H24N4O2/c1-12-4-3-8-22-14(12)10-20-17(22)18(2,13-5-6-13)21-16(23)15-11-19-7-9-24-15/h3-4,8,10,13,15,19H,5-7,9,11H2,1-2H3,(H,21,23)/t15-,18?/m0/s1
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n/an/an/an/a 290n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276001
PNG
(US10071974, Example 112 | US10071974, Example 113 ...)
Show SMILES CC(C)CC(C)(NC(=O)[C@@H]1CNCCO1)c1ncc2c(C)cccn12
Show InChI InChI=1S/C19H28N4O2/c1-13(2)10-19(4,22-17(24)16-12-20-7-9-25-16)18-21-11-15-14(3)6-5-8-23(15)18/h5-6,8,11,13,16,20H,7,9-10,12H2,1-4H3,(H,22,24)/t16-,19?/m0/s1
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n/an/an/an/a 380n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276005
PNG
(US10071974, Example 116 | US10071974, Example 117 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-7-21-14(12)10-19-16(21)17(2,3)20-15(22)13-9-18-6-8-23-11-13/h4-5,7,10,13,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 9.30n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276005
PNG
(US10071974, Example 116 | US10071974, Example 117 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-7-21-14(12)10-19-16(21)17(2,3)20-15(22)13-9-18-6-8-23-11-13/h4-5,7,10,13,18H,6,8-9,11H2,1-3H3,(H,20,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276010
PNG
(US10071974, Example 121 | US10071974, Example 122 ...)
Show SMILES Cc1nc(n2cccc(F)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-11-14-13(18)5-4-7-22(14)16(20-11)17(2,3)21-15(23)12-9-19-6-8-24-10-12/h4-5,7,12,19H,6,8-10H2,1-3H3,(H,21,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276024
PNG
(US10071974, Example 135 | US10071974, Example 136 ...)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H25N3O2/c1-13-5-4-9-21-15(13)6-7-16(21)18(2,3)20-17(22)14-11-19-8-10-23-12-14/h4-7,9,14,19H,8,10-12H2,1-3H3,(H,20,22)
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n/an/an/an/a 3.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276027
PNG
(US10071974, Example 138 | US10071974, Example 139 ...)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C20H28N4O2/c1-13-5-4-9-24-17(13)16(14-6-7-14)22-19(24)20(2,3)23-18(25)15-11-21-8-10-26-12-15/h4-5,9,14-15,21H,6-8,10-12H2,1-3H3,(H,23,25)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275900
PNG
(US10071974, Example 11 | US10577336, Example 11)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1ccnc2ccccc12
Show InChI InChI=1S/C17H21N3O2/c1-17(2,20-16(21)15-11-18-9-10-22-15)13-7-8-19-14-6-4-3-5-12(13)14/h3-8,15,18H,9-11H2,1-2H3,(H,20,21)/t15-/m0/s1
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n/an/an/an/a 26.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275905
PNG
(US10071974, Example 16 | US10071974, Example 17 | ...)
Show SMILES CC(C)(COc1nccc2ccccc12)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O3/c1-19(2,22-17(23)15-11-20-9-10-24-12-15)13-25-18-16-6-4-3-5-14(16)7-8-21-18/h3-8,15,20H,9-13H2,1-2H3,(H,22,23)
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n/an/an/an/a 3.00E+4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275918
PNG
(US10071974, Example 29 | US10577336, Example 29)
Show SMILES Cn1nc(c2c(F)cccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-16(2,19-15(22)12-9-18-7-8-23-12)14-13-10(17)5-4-6-11(13)21(3)20-14/h4-6,12,18H,7-9H2,1-3H3,(H,19,22)/t12-/m0/s1
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n/an/an/an/a 21.6n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275921
PNG
(US10071974, Example 32 | US10577336, Example 32)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-6-13-12(9-18-20(11)13)16(2,3)19-15(21)14-10-17-7-8-22-14/h4-6,9,14,17H,7-8,10H2,1-3H3,(H,19,21)/t14-/m0/s1
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n/an/an/an/a 10.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275922
PNG
(US10071974, Example 33 | US10071974, Example 34 | ...)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-6-15-14(10-19-21(12)15)17(2,3)20-16(22)13-9-18-7-8-23-11-13/h4-6,10,13,18H,7-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 5.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275925
PNG
(US10071974, Example 36 | US10577336, Example 36)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H22N4O2/c1-11-12-6-4-5-7-13(12)15(21-20-11)17(2,3)19-16(22)14-10-18-8-9-23-14/h4-7,14,18H,8-10H2,1-3H3,(H,19,22)/t14-/m0/s1
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n/an/an/an/a 25.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275929
PNG
(US10071974, Example 40 | US10071974, Example 41 | ...)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-15-6-4-5-7-16(15)17(11-21-13)19(2,3)22-18(23)14-10-20-8-9-24-12-14/h4-7,11,14,20H,8-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 0.800n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275929
PNG
(US10071974, Example 40 | US10071974, Example 41 | ...)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-15-6-4-5-7-16(15)17(11-21-13)19(2,3)22-18(23)14-10-20-8-9-24-12-14/h4-7,11,14,20H,8-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 0.700n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275936
PNG
(US10071974, Example 47 | US10071974, Example 48 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-11-14-7-4-5-8-15(14)17(21-13)19(2,3)22-18(23)16-12-20-9-6-10-24-16/h4-5,7-8,11,16,20H,6,9-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 18.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275951
PNG
(US10071974, Example 62 | US10071974, Example 63 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)10-8-18-6-7-22-9-10)14-11-4-3-5-12(17)13(11)23-20-14/h3-5,10,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 65.7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275951
PNG
(US10071974, Example 62 | US10071974, Example 63 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)10-8-18-6-7-22-9-10)14-11-4-3-5-12(17)13(11)23-20-14/h3-5,10,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 1.86E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275954
PNG
(US10071974, Example 65 | US10071974, Example 66 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-9-18-7-4-8-22-12)14-10-5-3-6-11(17)13(10)23-20-14/h3,5-6,12,18H,4,7-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 998n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%