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Patent code US10577354

Compile Data Set for Download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM332752
PNG
((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[6-...)
Show SMILES CO[C@H](C(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C22H23F2N7O3/c1-33-20(14-4-2-5-16(12-14)34-22(23)24)21(32)27-18-7-8-19(30-29-18)31-11-9-15(13-31)26-17-6-3-10-25-28-17/h2-8,10,12,15,20,22H,9,11,13H2,1H3,(H,26,28)(H,27,29,32)/t15-,20+/m1/s1
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n/an/a 24.7n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10577354 (2020)


BindingDB Entry DOI: 10.7270/Q2R49T4Z
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM332757
PNG
(N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...)
Show SMILES FC(F)(F)Oc1ccccc1CC(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1
Show InChI InChI=1S/C21H20F3N7O2/c22-21(23,24)33-16-5-2-1-4-14(16)12-20(32)27-18-7-8-19(30-29-18)31-11-9-15(13-31)26-17-6-3-10-25-28-17/h1-8,10,15H,9,11-13H2,(H,26,28)(H,27,29,32)/t15-/m1/s1
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n/an/a 25.2n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10577354 (2020)


BindingDB Entry DOI: 10.7270/Q2R49T4Z
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM332754
PNG
((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[6-[(3R)-3-(p...)
Show SMILES CO[C@H](C(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1)c1cccc(OC)c1
Show InChI InChI=1S/C22H25N7O3/c1-31-17-6-3-5-15(13-17)21(32-2)22(30)25-19-8-9-20(28-27-19)29-12-10-16(14-29)24-18-7-4-11-23-26-18/h3-9,11,13,16,21H,10,12,14H2,1-2H3,(H,24,26)(H,25,27,30)/t16-,21+/m1/s1
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n/an/a 29.8n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10577354 (2020)


BindingDB Entry DOI: 10.7270/Q2R49T4Z
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM332756
PNG
(N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...)
Show SMILES FC(F)(F)c1ccccc1CC(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1
Show InChI InChI=1S/C21H20F3N7O/c22-21(23,24)16-5-2-1-4-14(16)12-20(32)27-18-7-8-19(30-29-18)31-11-9-15(13-31)26-17-6-3-10-25-28-17/h1-8,10,15H,9,11-13H2,(H,26,28)(H,27,29,32)/t15-/m1/s1
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n/an/a 30.6n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10577354 (2020)


BindingDB Entry DOI: 10.7270/Q2R49T4Z
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM332755
PNG
(2-(2-Methoxyphenyl)-N-[6-[(3R)-3-(pyridazin-3-ylam...)
Show SMILES COc1ccccc1CC(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1
Show InChI InChI=1S/C21H23N7O2/c1-30-17-6-3-2-5-15(17)13-21(29)24-19-8-9-20(27-26-19)28-12-10-16(14-28)23-18-7-4-11-22-25-18/h2-9,11,16H,10,12-14H2,1H3,(H,23,25)(H,24,26,29)/t16-/m1/s1
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n/an/a 30.9n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10577354 (2020)


BindingDB Entry DOI: 10.7270/Q2R49T4Z
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM332753
PNG
((2S)-2-[3-(Trifluoromethoxy)phenyl]-2-methoxy-N-[6...)
Show SMILES CO[C@H](C(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H22F3N7O3/c1-34-20(14-4-2-5-16(12-14)35-22(23,24)25)21(33)28-18-7-8-19(31-30-18)32-11-9-15(13-32)27-17-6-3-10-26-29-17/h2-8,10,12,15,20H,9,11,13H2,1H3,(H,27,29)(H,28,30,33)/t15-,20+/m1/s1
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n/an/a 95.7n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10577354 (2020)


BindingDB Entry DOI: 10.7270/Q2R49T4Z
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%