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Patent code US10577367

Compile Data Set for Download or QSAR

Found 528 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374393
PNG
(US10246456, Example 573 | US10577367, Example 573)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc([C@@H]2CCCN2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C26H30N6O/c1-2-6-21(27)24-9-4-8-22(31-24)17-13-19(23-10-5-12-28-23)20-15-29-32(25(20)14-17)26-11-3-7-18(16-33)30-26/h3-4,7-9,11,13-15,21,23,28,33H,2,5-6,10,12,16,27H2,1H3/t21-,23-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374395
PNG
(US10246456, Example 575 | US10577367, Example 575)
Show SMILES COCCC[C@H](N)c1cccc(n1)-c1cc(-c2ccn(C)n2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C27H29N7O2/c1-33-12-11-24(32-33)20-14-18(23-8-4-9-25(31-23)22(28)7-5-13-36-2)15-26-21(20)16-29-34(26)27-10-3-6-19(17-35)30-27/h3-4,6,8-12,14-16,22,35H,5,7,13,17,28H2,1-2H3/t22-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374404
PNG
(US10246456, Example 586 | US10577367, Example 586)
Show SMILES COCCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@H](C)N
Show InChI InChI=1S/C23H25N5O3/c1-15(24)19-6-4-7-20(27-19)16-11-21-18(22(12-16)31-10-9-30-2)13-25-28(21)23-8-3-5-17(14-29)26-23/h3-8,11-13,15,29H,9-10,14,24H2,1-2H3/t15-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374412
PNG
(US10246456, Example 595 | US10577367, Example 414)
Show SMILES CCC[C@H](N)c1ccnc(n1)-c1cc(OCCOC)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C24H28N6O3/c1-3-5-19(25)20-8-9-26-24(29-20)16-12-21-18(22(13-16)33-11-10-32-2)14-27-30(21)23-7-4-6-17(15-31)28-23/h4,6-9,12-14,19,31H,3,5,10-11,15,25H2,1-2H3/t19-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM433289
PNG
(N-methyl-1-(3-(1-(6-methylpyridin-2-yl)-1H-indazol...)
Show SMILES CNCc1cccc(n1)-c1ccc2cnn(-c3cccc(C)n3)c2c1
Show InChI InChI=1S/C20H19N5/c1-14-5-3-8-20(23-14)25-19-11-15(9-10-16(19)12-22-25)18-7-4-6-17(24-18)13-21-2/h3-12,21H,13H2,1-2H3
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374070
PNG
(2-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyrimid...)
Show SMILES Nc1cncc(c1)-c1ccc2cnn(-c3nccc(n3)C#N)c2c1
Show InChI InChI=1S/C17H11N7/c18-7-15-3-4-21-17(23-15)24-16-6-11(1-2-12(16)9-22-24)13-5-14(19)10-20-8-13/h1-6,8-10H,19H2
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374071
PNG
(5-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-...)
Show SMILES Nc1cncc(c1)-c1ccc2cnn(-c3cccc(n3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H12F3N5/c19-18(20,21)16-2-1-3-17(25-16)26-15-7-11(4-5-12(15)9-24-26)13-6-14(22)10-23-8-13/h1-10H,22H2
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374076
PNG
(US10246456, Example 49 | US10577367, Example 49 | ...)
Show SMILES COC(=O)c1cc(cc2n(ncc12)-c1cccc(n1)C#N)-c1cncc(N)c1
Show InChI InChI=1S/C20H14N6O2/c1-28-20(27)16-6-12(13-5-14(22)10-23-9-13)7-18-17(16)11-24-26(18)19-4-2-3-15(8-21)25-19/h2-7,9-11H,22H2,1H3
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374079
PNG
(6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyri...)
Show SMILES NC(=O)c1cc(cc2n(ncc12)-c1cccc(n1)C(F)(F)F)-c1cncc(N)c1
Show InChI InChI=1S/C19H13F3N6O/c20-19(21,22)16-2-1-3-17(27-16)28-15-6-10(11-4-12(23)8-25-7-11)5-13(18(24)29)14(15)9-26-28/h1-9H,23H2,(H2,24,29)
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374082
PNG
(US10246456, Example 56 | US10577367, Example 57 | ...)
Show SMILES COC(=O)c1cc(cc2n(ncc12)-c1cccc(n1)C(F)(F)F)-c1cccc(n1)C(C)N
Show InChI InChI=1S/C22H18F3N5O2/c1-12(26)16-5-3-6-17(28-16)13-9-14(21(31)32-2)15-11-27-30(18(15)10-13)20-8-4-7-19(29-20)22(23,24)25/h3-12H,26H2,1-2H3
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374084
PNG
(6-(6-(1-aminoethyl)pyridin-2-yl)-N-methyl-1-(6-(tr...)
Show SMILES CNC(=O)c1cc(cc2n(ncc12)-c1cccc(n1)C(F)(F)F)-c1cccc(n1)C(C)N
Show InChI InChI=1S/C22H19F3N6O/c1-12(26)16-5-3-6-17(29-16)13-9-14(21(32)27-2)15-11-28-31(18(15)10-13)20-8-4-7-19(30-20)22(23,24)25/h3-12H,26H2,1-2H3,(H,27,32)
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374088
PNG
(6-(6-(5-aminopyridin-3-yl)imidazo[1,5-a]pyridin-3-...)
Show SMILES Nc1cncc(c1)-c1ccc2cnc(-c3cccc(n3)C#N)n2c1
Show InChI InChI=1S/C18H12N6/c19-7-15-2-1-3-17(23-15)18-22-10-16-5-4-12(11-24(16)18)13-6-14(20)9-21-8-13/h1-6,8-11H,20H2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374091
PNG
(2-(aminomethyl)-6-(1-(6-(trifluoromethyl)pyridin-2...)
Show SMILES NCc1cc(N)cc(n1)-c1ccc2cnn(-c3cccc(n3)C(F)(F)F)c2c1
Show InChI InChI=1S/C19H15F3N6/c20-19(21,22)17-2-1-3-18(27-17)28-16-6-11(4-5-12(16)10-25-28)15-8-13(24)7-14(9-23)26-15/h1-8,10H,9,23H2,(H2,24,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374096
PNG
(3-amino-N-(2-aminoethyl)-5-(1-(6-(trifluoromethyl)...)
Show SMILES NCCNC(=O)c1cc(N)cc(c1)-c1ccc2cnn(-c3cccc(n3)C(F)(F)F)c2c1
Show InChI InChI=1S/C22H19F3N6O/c23-22(24,25)19-2-1-3-20(30-19)31-18-11-13(4-5-14(18)12-29-31)15-8-16(10-17(27)9-15)21(32)28-7-6-26/h1-5,8-12H,6-7,26-27H2,(H,28,32)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374107
PNG
(6-(6-(1-aminoethyl)pyridin-2-yl)-N-methyl-1-(6-met...)
Show SMILES CNC(=O)c1cc(cc2n(ncc12)-c1cccc(C)n1)-c1cccc(n1)C(C)N
Show InChI InChI=1S/C22H22N6O/c1-13-6-4-9-21(26-13)28-20-11-15(19-8-5-7-18(27-19)14(2)23)10-16(22(29)24-3)17(20)12-25-28/h4-12,14H,23H2,1-3H3,(H,24,29)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374123
PNG
((S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazo...)
Show SMILES C[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C20H19N5O/c1-13(21)17-5-3-6-18(24-17)14-8-9-15-11-22-25(19(15)10-14)20-7-2-4-16(12-26)23-20/h2-11,13,26H,12,21H2,1H3/t13-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374129
PNG
(US10246456, Example 214 | US10577367, Example 214)
Show SMILES CC(N)c1cccc(n1)-c1cc(C#N)c2cnn(-c3cccc(C)n3)c2c1
Show InChI InChI=1S/C21H18N6/c1-13-5-3-8-21(25-13)27-20-10-15(9-16(11-22)17(20)12-24-27)19-7-4-6-18(26-19)14(2)23/h3-10,12,14H,23H2,1-2H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374090
PNG
(1-(6-(3-(6-(trifluoromethyl)pyridin-2-yl)imidazo[1...)
Show SMILES CC(N)c1cccc(n1)-c1ccc2cnc(-c3cccc(n3)C(F)(F)F)n2c1
Show InChI InChI=1S/C20H16F3N5/c1-12(24)15-4-2-5-16(26-15)13-8-9-14-10-25-19(28(14)11-13)17-6-3-7-18(27-17)20(21,22)23/h2-12H,24H2,1H3
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374140
PNG
(US10246456, Example 247 | US10577367, Example 247)
Show SMILES Cc1cccc(n1)-n1ncc2ccc(cc12)-c1cccc(n1)C(N)CCO
Show InChI InChI=1S/C21H21N5O/c1-14-4-2-7-21(24-14)26-20-12-15(8-9-16(20)13-23-26)18-5-3-6-19(25-18)17(22)10-11-27/h2-9,12-13,17,27H,10-11,22H2,1H3
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374157
PNG
(US10246456, Example 279 | US10577367, Example 279)
Show SMILES COCc1cccc(n1)-n1ncc2ccc(cc12)-c1cccc(n1)C(C)N
Show InChI InChI=1S/C21H21N5O/c1-14(22)18-6-4-7-19(25-18)15-9-10-16-12-23-26(20(16)11-15)21-8-3-5-17(24-21)13-27-2/h3-12,14H,13,22H2,1-2H3
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374169
PNG
(US10246456, Example 302 | US10577367, Example 302)
Show SMILES CC(N)c1cccc(n1)-c1ccc2cnc(-c3cccc(CO)n3)n2c1
Show InChI InChI=1S/C20H19N5O/c1-13(21)17-5-3-6-18(24-17)14-8-9-16-10-22-20(25(16)11-14)19-7-2-4-15(12-26)23-19/h2-11,13,26H,12,21H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374180
PNG
(US10246456, Example 318 | US10577367, Example 318)
Show SMILES CC[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C21H21N5O/c1-2-17(22)19-7-4-6-18(25-19)14-9-10-15-12-23-26(20(15)11-14)21-8-3-5-16(13-27)24-21/h3-12,17,27H,2,13,22H2,1H3/t17-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374181
PNG
(US10246456, Example 319 | US10577367, Example 319)
Show SMILES CC(N)c1cccc(n1)-c1cc(-c2cc[nH]n2)c2cnn(-c3cccc(C)n3)c2c1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374185
PNG
(US10246456, Example 325 | US10577367, Example 325)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC(O)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C26H30N6O2/c1-2-5-21(27)23-8-4-7-22(30-23)17-12-24(31-11-10-19(34)15-31)20-14-28-32(25(20)13-17)26-9-3-6-18(16-33)29-26/h3-4,6-9,12-14,19,21,33-34H,2,5,10-11,15-16,27H2,1H3/t19?,21-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374192
PNG
(US10246456, Example 332 | US10577367, Example 332)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CC(CO)(CCl)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C27H31ClN6O2/c1-2-5-21(29)23-8-4-7-22(32-23)18-10-24(33-15-27(14-28,16-33)17-36)20-12-30-34(25(20)11-18)26-9-3-6-19(13-35)31-26/h3-4,6-12,21,35-36H,2,5,13-17,29H2,1H3/t21-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374208
PNG
(US10246456, Example 348 | US10577367, Example 348)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CC(C2)C(O)=O)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C26H28N6O3/c1-2-5-20(27)22-8-4-7-21(30-22)16-10-23(31-13-17(14-31)26(34)35)19-12-28-32(24(19)11-16)25-9-3-6-18(15-33)29-25/h3-4,6-12,17,20,33H,2,5,13-15,27H2,1H3,(H,34,35)/t20-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374214
PNG
(US10246456, Example 355 | US10577367, Example 355)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-n2cncn2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C22H20N8O/c1-14(23)18-5-3-6-19(28-18)15-8-20(29-13-24-12-26-29)17-10-25-30(21(17)9-15)22-7-2-4-16(11-31)27-22/h2-10,12-14,31H,11,23H2,1H3/t14-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374219
PNG
(US10246456, Example 360 | US10577367, Example 360)
Show SMILES CC[C@H](N)c1cccc(n1)-c1cc(-c2ccn(C)n2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C25H25N7O/c1-3-20(26)23-8-5-7-21(29-23)16-12-18(22-10-11-31(2)30-22)19-14-27-32(24(19)13-16)25-9-4-6-17(15-33)28-25/h4-14,20,33H,3,15,26H2,1-2H3/t20-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374221
PNG
(US10246456, Example 362 | US10577367, Example 362)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-c2nnc(C)s2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C23H21N7OS/c1-13(24)19-6-4-7-20(27-19)15-9-17(23-29-28-14(2)32-23)18-11-25-30(21(18)10-15)22-8-3-5-16(12-31)26-22/h3-11,13,31H,12,24H2,1-2H3/t13-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374246
PNG
(US10246456, Example 387 | US10577367, Example 387)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-c2ccnn2C(F)F)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C24H21F2N7O/c1-14(27)19-5-3-6-20(31-19)15-10-17(21-8-9-28-33(21)24(25)26)18-12-29-32(22(18)11-15)23-7-2-4-16(13-34)30-23/h2-12,14,24,34H,13,27H2,1H3/t14-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM433497
PNG
((R)-N-((S)-1-(6-(1-(6-acetylpyridin-2-yl)-1H-indaz...)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(n3)[C@@H](C)O)c2c1
Show InChI InChI=1S/C23H25N5O/c1-3-6-18(24)21-9-4-8-20(26-21)16-11-12-17-14-25-28(22(17)13-16)23-10-5-7-19(27-23)15(2)29/h4-5,7-15,18,29H,3,6,24H2,1-2H3/t15-,18+/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374275
PNG
((6-(6-(8-amino-8-propyl-5,6,7,8-tetrahydroquinolin...)
Show SMILES CCCC1(N)CCCc2ccc(nc12)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C25H27N5O/c1-2-12-25(26)13-4-5-17-10-11-21(29-24(17)25)18-8-9-19-15-27-30(22(19)14-18)23-7-3-6-20(16-31)28-23/h3,6-11,14-15,31H,2,4-5,12-13,16,26H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374283
PNG
((4S)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)py...)
Show SMILES COCCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@H](N)C(F)CCO
Show InChI InChI=1S/C25H28FN5O4/c1-34-10-11-35-23-13-16(20-5-3-6-21(30-20)25(27)19(26)8-9-32)12-22-18(23)14-28-31(22)24-7-2-4-17(15-33)29-24/h2-7,12-14,19,25,32-33H,8-11,15,27H2,1H3/t19?,25-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM433512
PNG
(Step 1. Synthesis of 1-(6-bromopyridin-2-yl)-2-flu...)
Show SMILES COCCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@@H](N)C(C)F
Show InChI InChI=1S/C24H26FN5O3/c1-15(25)24(26)20-7-4-6-19(29-20)16-11-21-18(22(12-16)33-10-9-32-2)13-27-30(21)23-8-3-5-17(14-31)28-23/h3-8,11-13,15,24,31H,9-10,14,26H2,1-2H3/t15?,24-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374293
PNG
((S)-(6-(6-(6-(1-aminopent-3-yn-1-yl)pyridin-2-yl)-...)
Show SMILES CCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@@H](N)CC#CC
Show InChI InChI=1S/C25H25N5O2/c1-3-5-9-20(26)22-11-7-10-21(29-22)17-13-23-19(24(14-17)32-4-2)15-27-30(23)25-12-6-8-18(16-31)28-25/h6-8,10-15,20,31H,4,9,16,26H2,1-2H3/t20-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374297
PNG
((6-(6-(6-((1R,2R)-1-amino-2-methoxybutyl)pyridin-2...)
Show SMILES CCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@@H](N)[C@@H](CC)OC
Show InChI InChI=1S/C25H29N5O3/c1-4-22(32-3)25(26)20-10-7-9-19(29-20)16-12-21-18(23(13-16)33-5-2)14-27-30(21)24-11-6-8-17(15-31)28-24/h6-14,22,25,31H,4-5,15,26H2,1-3H3/t22-,25-/m1/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM433529
PNG
(Step 1. Synthesis of (R)-2-methyl-N—((S)-1-(6...)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(n3)[C@@H](O)C(F)(F)F)c2c1
Show InChI InChI=1S/C23H22F3N5O/c1-2-5-16(27)18-7-3-6-17(29-18)14-10-11-15-13-28-31(20(15)12-14)21-9-4-8-19(30-21)22(32)23(24,25)26/h3-4,6-13,16,22,32H,2,5,27H2,1H3/t16-,22+/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374310
PNG
((S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(3-meth...)
Show SMILES COCCCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@H](C)N
Show InChI InChI=1S/C24H27N5O3/c1-16(25)20-7-4-8-21(28-20)17-12-22-19(23(13-17)32-11-5-10-31-2)14-26-29(22)24-9-3-6-18(15-30)27-24/h3-4,6-9,12-14,16,30H,5,10-11,15,25H2,1-2H3/t16-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374318
PNG
((6-(6-(6-(1-aminocyclobutyl)pyridin-2-yl)-4-(2-met...)
Show SMILES COCCOc1cc(cc2n(ncc12)-c1cncc(CO)n1)-c1cccc(n1)C1(N)CCC1
Show InChI InChI=1S/C24H26N6O3/c1-32-8-9-33-21-11-16(19-4-2-5-22(29-19)24(25)6-3-7-24)10-20-18(21)13-27-30(20)23-14-26-12-17(15-31)28-23/h2,4-5,10-14,31H,3,6-9,15,25H2,1H3
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374325
PNG
((6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(tetrah...)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(C2CCCO2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C26H29N5O2/c1-2-6-21(27)23-9-4-8-22(30-23)17-13-19(25-10-5-12-33-25)20-15-28-31(24(20)14-17)26-11-3-7-18(16-32)29-26/h3-4,7-9,11,13-15,21,25,32H,2,5-6,10,12,16,27H2,1H3/t21-,25?/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374326
PNG
((6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-((2R,5R...)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc([C@H]2CC[C@@H](C)O2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C27H31N5O2/c1-3-6-22(28)24-9-5-8-23(31-24)18-13-20(26-12-11-17(2)34-26)21-15-29-32(25(21)14-18)27-10-4-7-19(16-33)30-27/h4-5,7-10,13-15,17,22,26,33H,3,6,11-12,16,28H2,1-2H3/t17-,22+,26-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374334
PNG
(US10246456, Example 486 | US10577367, Example 486)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3nccc(n3)C(F)F)c2c1
Show InChI InChI=1S/C21H20F2N6/c1-2-4-15(24)17-6-3-5-16(27-17)13-7-8-14-12-26-29(19(14)11-13)21-25-10-9-18(28-21)20(22)23/h3,5-12,15,20H,2,4,24H2,1H3/t15-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374356
PNG
(US10246456, Example 509 | US10577367, Example 509)
Show SMILES COCCC[C@H](N)c1cccc(n1)-c1cc(OC)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C24H27N5O3/c1-31-11-5-7-19(25)21-9-4-8-20(28-21)16-12-22-18(23(13-16)32-2)14-26-29(22)24-10-3-6-17(15-30)27-24/h3-4,6,8-10,12-14,19,30H,5,7,11,15,25H2,1-2H3/t19-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374361
PNG
(US10246456, Example 514 | US10577367, Example 514)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(OCC(F)(F)F)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C24H24F3N5O2/c1-2-5-18(28)20-8-4-7-19(31-20)15-10-21-17(22(11-15)34-14-24(25,26)27)12-29-32(21)23-9-3-6-16(13-33)30-23/h3-4,6-12,18,33H,2,5,13-14,28H2,1H3/t18-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374364
PNG
(US10246456, Example 517 | US10577367, Example 517)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(CN(C)C)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C25H30N6O/c1-4-7-21(26)23-10-6-9-22(29-23)17-12-18(15-30(2)3)20-14-27-31(24(20)13-17)25-11-5-8-19(16-32)28-25/h5-6,8-14,21,32H,4,7,15-16,26H2,1-3H3/t21-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374383
PNG
(US10246456, Example 538 | US10577367, Example 538)
Show SMILES NC(C1CC1)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C22H21N5O/c23-22(14-7-8-14)19-5-2-4-18(26-19)15-9-10-16-12-24-27(20(16)11-15)21-6-1-3-17(13-28)25-21/h1-6,9-12,14,22,28H,7-8,13,23H2
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n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374387
PNG
(US10246456, Example 544 | US10577367, Example 544)
Show SMILES CN(C)C(=O)C(N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C22H22N6O2/c1-27(2)22(30)21(23)18-7-4-6-17(26-18)14-9-10-15-12-24-28(19(15)11-14)20-8-3-5-16(13-29)25-20/h3-12,21,29H,13,23H2,1-2H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374398
PNG
(US10246456, Example 578 | US10577367, Example 578)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(-n2ccnn2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C24H24N8O/c1-2-5-19(25)21-8-4-7-20(29-21)16-12-22(31-11-10-26-30-31)18-14-27-32(23(18)13-16)24-9-3-6-17(15-33)28-24/h3-4,6-14,19,33H,2,5,15,25H2,1H3/t19-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374078
PNG
(6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyri...)
Show SMILES Nc1cncc(c1)-c1cc(C(O)=O)c2cnn(-c3cccc(n3)C(F)(F)F)c2c1
Show InChI InChI=1S/C19H12F3N5O2/c20-19(21,22)16-2-1-3-17(26-16)27-15-6-10(11-4-12(23)8-24-7-11)5-13(18(28)29)14(15)9-25-27/h1-9H,23H2,(H,28,29)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374080
PNG
((6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyr...)
Show SMILES Nc1cncc(c1)-c1cc(CO)c2cnn(-c3cccc(n3)C(F)(F)F)c2c1
Show InChI InChI=1S/C19H14F3N5O/c20-19(21,22)17-2-1-3-18(26-17)27-16-6-11(12-5-14(23)8-24-7-12)4-13(10-28)15(16)9-25-27/h1-9,28H,10,23H2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%