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Patent code US10577374

Compile Data Set for Download or QSAR

Found 360 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348609
PNG
(US10577374, Compound 332 | US9790229, Compound 332)
Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F
Show InChI InChI=1S/C21H22ClF5N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15+,16-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348614
PNG
(US10577374, Compound 337 | US9790229, Compound 337)
Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F
Show InChI InChI=1S/C21H22Cl2F4N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15+,16-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348428
PNG
(US10577374, Compound 151 | US9790229, Compound 151)
Show SMILES CC(C)c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348559
PNG
(US10577374, Compound 282 | US9790229, Compound 282)
Show SMILES C[C@H]1CCN(C[C@@H]1N1CCCC(Nc2cccc(Cl)c2)C1=O)c1ncnc(N)c1F
Show InChI InChI=1S/C21H26ClFN6O/c1-13-7-9-28(20-18(23)19(24)25-12-26-20)11-17(13)29-8-3-6-16(21(29)30)27-15-5-2-4-14(22)10-15/h2,4-5,10,12-13,16-17,27H,3,6-9,11H2,1H3,(H2,24,25,26)/t13-,16?,17-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348585
PNG
(US10577374, Compound 308 | US9790229, Compound 308)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3cc(Cl)cc(c3)C(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H23ClF4N6O/c22-13-7-12(21(24,25)26)8-14(9-13)30-16-4-2-6-32(20(16)33)15-3-1-5-31(10-15)19-17(23)18(27)28-11-29-19/h7-9,11,15-16,30H,1-6,10H2,(H2,27,28,29)/t15-,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348587
PNG
(US10577374, Compound 310 | US9790229, Compound 310)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C22H23F7N6O/c23-17-18(30)31-11-32-19(17)34-5-1-3-15(10-34)35-6-2-4-16(20(35)36)33-14-8-12(21(24,25)26)7-13(9-14)22(27,28)29/h7-9,11,15-16,33H,1-6,10H2,(H2,30,31,32)/t15-,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348390
PNG
(US10577374, Compound 113 | US9790229, Compound 113)
Show SMILES Nc1ncnc(N2CCCC(C2)c2nc(NC(=O)Nc3c(F)cc(F)cc3N3CCCC3)cs2)c1C#N
Show InChI InChI=1S/C24H25F2N9OS/c25-15-8-17(26)20(18(9-15)34-5-1-2-6-34)33-24(36)32-19-12-37-23(31-19)14-4-3-7-35(11-14)22-16(10-27)21(28)29-13-30-22/h8-9,12-14H,1-7,11H2,(H2,28,29,30)(H2,32,33,36)
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348423
PNG
(US10577374, Compound 146 | US9790229, Compound 146)
Show SMILES Fc1cccc(N2CCCC2)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348426
PNG
(US10577374, Compound 149 | US9790229, Compound 149)
Show SMILES O[C@@H]1CCN(C1)c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348429
PNG
(US10577374, Compound 152 | US9790229, Compound 152)
Show SMILES OC[C@@H]1CCCN1c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348431
PNG
(US10577374, Compound 154 | US9790229, Compound 154)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348432
PNG
(US10577374, Compound 155 | US9790229, Compound 155)
Show SMILES O[C@H]1CCN(C1)c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348577
PNG
(US10577374, Compound 300 | US9790229, Compound 300)
Show SMILES FC(F)(F)c1cc(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348621
PNG
(US10577374, Compound 344 | US9790229, Compound 344)
Show SMILES Nc1ncnc(N2CCOCC(C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23Cl2FN6O2/c21-12-6-13(22)8-14(7-12)27-16-2-1-3-29(20(16)30)15-9-28(4-5-31-10-15)19-17(23)18(24)25-11-26-19/h6-8,11,15-16,27H,1-5,9-10H2,(H2,24,25,26)
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348622
PNG
(US10577374, Compound 345 | US9790229, Compound 345)
Show SMILES Nc1ncnc(N2CCOCC(C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23ClF2N6O2/c21-12-6-13(22)8-14(7-12)27-16-2-1-3-29(20(16)30)15-9-28(4-5-31-10-15)19-17(23)18(24)25-11-26-19/h6-8,11,15-16,27H,1-5,9-10H2,(H2,24,25,26)
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348323
PNG
(US10577374, Compound 46 | US9790229, Compound 46)
Show SMILES O=C(Nc1cccc(c1)[C@H]1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348389
PNG
(US10577374, Compound 112 | US9790229, Compound 112)
Show SMILES Fc1cc(F)c(NC(=O)Nc2csc(n2)C2CCCN(C2)c2ncnc3[nH]ncc23)c(c1)N1CCCC1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348430
PNG
(US10577374, Compound 153 | US9790229, Compound 153)
Show SMILES Clc1cccc(Cl)c1NC(=O)Nc1cccc(c1)[C@H]1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348552
PNG
(US10577374, Compound 275 | US9790229, Compound 275)
Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348592
PNG
(US10577374, Compound 315 | US9790229, Compound 315)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23Cl2FN6O/c21-12-7-13(22)9-14(8-12)27-16-4-2-6-29(20(16)30)15-3-1-5-28(10-15)19-17(23)18(24)25-11-26-19/h7-9,11,15-16,27H,1-6,10H2,(H2,24,25,26)/t15-,16-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348594
PNG
(US10577374, Compound 317 | US9790229, Compound 317)
Show SMILES Fc1cc(Cl)cc(N[C@H]2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1
PDB
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348632
PNG
(US10577374, Compound 355 | US9790229, Compound 355)
Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CC[C@@H](Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ncc12
PDB
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348634
PNG
(US10577374, Compound 357 | US9790229, Compound 357)
Show SMILES Clc1cc(Cl)cc(N[C@H]2CCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1
PDB
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348314
PNG
(US10577374, Compound 37 | US9790229, Compound 37)
Show SMILES O=C(Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM434888
PNG
(US10577374, Compound 49)
Show SMILES Nc1c(F)cc(F)cc1N1CCCC1.O=CNc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348384
PNG
(US10577374, Compound 107 | US9790229, Compound 107)
Show SMILES O=C(Nc1csc(n1)C1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1
PDB
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348554
PNG
(US10577374, Compound 277 | US9790229, Compound 277)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23ClF2N6O/c21-12-7-13(22)9-14(8-12)27-16-4-2-6-29(20(16)30)15-3-1-5-28(10-15)19-17(23)18(24)25-11-26-19/h7-9,11,15-16,27H,1-6,10H2,(H2,24,25,26)/t15-,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348578
PNG
(US10577374, Compound 301 | US9790229, Compound 301)
Show SMILES Fc1c(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)cc1Cl
PDB
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348579
PNG
(US10577374, Compound 302 | US9790229, Compound 302)
Show SMILES FC(F)(F)c1cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)cc(c1)C(F)(F)F
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348589
PNG
(US10577374, Compound 312 | US9790229, Compound 312)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCC[C@H](Nc3cc(Cl)cc(c3)C(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H23ClF4N6O/c22-13-7-12(21(24,25)26)8-14(9-13)30-16-4-2-6-32(20(16)33)15-3-1-5-31(10-15)19-17(23)18(27)28-11-29-19/h7-9,11,15-16,30H,1-6,10H2,(H2,27,28,29)/t15-,16+/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348596
PNG
(US10577374, Compound 319 | US9790229, Compound 319)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3ccccc3S(=O)(=O)c3ccccc3)C2=O)c1F
Show InChI InChI=1S/C26H29FN6O3S/c27-23-24(28)29-17-30-25(23)32-14-6-8-18(16-32)33-15-7-12-21(26(33)34)31-20-11-4-5-13-22(20)37(35,36)19-9-2-1-3-10-19/h1-5,9-11,13,17-18,21,31H,6-8,12,14-16H2,(H2,28,29,30)/t18-,21?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348597
PNG
(US10577374, Compound 320 | US9790229, Compound 320)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3ccccc3S(=O)(=O)C3CCCCC3)C2=O)c1F
Show InChI InChI=1S/C26H35FN6O3S/c27-23-24(28)29-17-30-25(23)32-14-6-8-18(16-32)33-15-7-12-21(26(33)34)31-20-11-4-5-13-22(20)37(35,36)19-9-2-1-3-10-19/h4-5,11,13,17-19,21,31H,1-3,6-10,12,14-16H2,(H2,28,29,30)/t18-,21?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348611
PNG
(US10577374, Compound 334 | US9790229, Compound 334)
Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F
Show InChI InChI=1S/C21H22Cl2F4N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15?,16-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348624
PNG
(US10577374, Compound 347 | US9790229, Compound 347)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C21H23ClF2N6O/c22-13-8-14(23)10-15(9-13)28-17-5-1-2-7-30(21(17)31)16-4-3-6-29(11-16)20-18(24)19(25)26-12-27-20/h1-2,8-10,12,16-17,28H,3-7,11H2,(H2,25,26,27)/t16-,17-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348626
PNG
(US10577374, Compound 349 | US9790229, Compound 349)
Show SMILES Nc1ncnc(N2CCC(C(C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F
Show InChI InChI=1S/C22H22ClF5N6O/c23-12-7-13(24)9-14(8-12)32-16-3-1-2-5-34(21(16)35)17-10-33(6-4-15(17)22(26,27)28)20-18(25)19(29)30-11-31-20/h1-2,7-9,11,15-17,32H,3-6,10H2,(H2,29,30,31)/t15?,16-,17?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348327
PNG
(US10577374, Compound 50 | US9790229, Compound 50)
Show SMILES Clc1cccc(N2CCCC2)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
PDB
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348388
PNG
(US10577374, Compound 111 | US9790229, Compound 111)
Show SMILES Fc1cc(F)c(NC(=O)Nc2csc(n2)C2CCCN(C2)c2ncnc3[nH]ccc23)c(c1)N1CCCC1
PDB
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348434
PNG
(US10577374, Compound 157 | US9790229, Compound 157)
Show SMILES CO[C@H]1CCN(C1)c1ccccc1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12
PDB
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348553
PNG
(US10577374, Compound 276 | US9790229, Compound 276)
Show SMILES Clc1cc(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1
PDB
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348555
PNG
(US10577374, Compound 278 | US9790229, Compound 278)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23Cl2FN6O/c21-12-7-13(22)9-14(8-12)27-16-4-2-6-29(20(16)30)15-3-1-5-28(10-15)19-17(23)18(24)25-11-26-19/h7-9,11,15-16,27H,1-6,10H2,(H2,24,25,26)/t15-,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348560
PNG
(US10577374, Compound 283 | US9790229, Compound 283)
Show SMILES Nc1ncnc(N2C[C@@H](O)C[C@H](C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23Cl2FN6O2/c21-11-4-12(22)6-13(5-11)27-16-2-1-3-29(20(16)31)14-7-15(30)9-28(8-14)19-17(23)18(24)25-10-26-19/h4-6,10,14-16,27,30H,1-3,7-9H2,(H2,24,25,26)/t14-,15+,16?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348586
PNG
(US10577374, Compound 309 | US9790229, Compound 309)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3cc(Cl)c(F)c(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H22Cl2F2N6O/c21-13-7-11(8-14(22)16(13)23)28-15-4-2-6-30(20(15)31)12-3-1-5-29(9-12)19-17(24)18(25)26-10-27-19/h7-8,10,12,15,28H,1-6,9H2,(H2,25,26,27)/t12-,15?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348588
PNG
(US10577374, Compound 311 | US9790229, Compound 311)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(c3)C(F)(F)F)C2=O)c1F
Show InChI InChI=1S/C21H23ClF4N6O/c22-13-7-12(21(24,25)26)8-14(9-13)30-16-4-2-6-32(20(16)33)15-3-1-5-31(10-15)19-17(23)18(27)28-11-29-19/h7-9,11,15-16,30H,1-6,10H2,(H2,27,28,29)/t15-,16-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348590
PNG
(US10577374, Compound 313 | US9790229, Compound 313)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCC[C@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23ClF2N6O/c21-12-7-13(22)9-14(8-12)27-16-4-2-6-29(20(16)30)15-3-1-5-28(10-15)19-17(23)18(24)25-11-26-19/h7-9,11,15-16,27H,1-6,10H2,(H2,24,25,26)/t15-,16+/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348603
PNG
(US10577374, Compound 326 | US9790229, Compound 326)
Show SMILES Nc1ncnc(N2CC[C@H](O)[C@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C20H23Cl2FN6O2/c21-11-6-12(22)8-13(7-11)27-14-2-1-4-29(20(14)31)15-9-28(5-3-16(15)30)19-17(23)18(24)25-10-26-19/h6-8,10,14-16,27,30H,1-5,9H2,(H2,24,25,26)/t14-,15+,16+/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348612
PNG
(US10577374, Compound 335 | US9790229, Compound 335)
Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F
Show InChI InChI=1S/C21H22Cl2F4N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15-,16-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348616
PNG
(US10577374, Compound 339 | US9790229, Compound 339)
Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CCCC(Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ccc12
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348625
PNG
(US10577374, Compound 348 | US9790229, Compound 348)
Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CC(O)C(O)C[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F
Show InChI InChI=1S/C21H25ClF2N6O3/c22-11-4-12(23)6-13(5-11)28-15-7-16(31)17(32)9-30(21(15)33)14-2-1-3-29(8-14)20-18(24)19(25)26-10-27-20/h4-6,10,14-17,28,31-32H,1-3,7-9H2,(H2,25,26,27)/t14-,15-,16?,17?/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348627
PNG
(US10577374, Compound 350 | US9790229, Compound 350)
Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F
Show InChI InChI=1S/C22H22ClF5N6O/c23-12-7-13(24)9-14(8-12)32-16-3-1-2-5-34(21(16)35)17-10-33(6-4-15(17)22(26,27)28)20-18(25)19(29)30-11-31-20/h1-2,7-9,11,15-17,32H,3-6,10H2,(H2,29,30,31)/t15-,16-,17-/m1/s1
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Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM348629
PNG
(US10577374, Compound 352 | US9790229, Compound 352)
Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@H]3CN(CC[C@@H]3C(F)(F)F)c3ncnc4[nH]ccc34)C2=O)c1
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n/an/a<100n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.

US Patent


Assay Description
BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...


US Patent US10577374 (2020)


BindingDB Entry DOI: 10.7270/Q2805502
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%