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Patent code US10577383

Compile Data Set for Download or QSAR
Found 78 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eosinophil peroxidase


(Human)
BDBM434842
PNG
(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,...)
Show SMILES Nc1cc([C@@H]2CCNCCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
EPX bromination activity was measured in 100 mM KPi (pH 7.4) by monitoring the H2O2 catalyzed formation of 3-bromo tyrosine from tyrosine and potassi...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434842
PNG
(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,...)
Show SMILES Nc1cc([C@@H]2CCNCCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434851
PNG
(7-{17-Oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,...)
Show SMILES Nc1cc(C2CCNCc3cccc(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434854
PNG
(7-{14-Fluoro-17-oxa-3,4,10-triazatetracyclo[17.3.1...)
Show SMILES Nc1cc(C2CCNCc3cc(F)cc(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434868
PNG
(7-[(17R)-18-Phenyl-16-oxa-2,8,9-triazapentacyclo[1...)
Show SMILES Nc1cc(C2CCNC34CCC(CC3)([C@@H](C4)Oc3cccc(Cn4cc2cn4)c3)c2ccccc2)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434845
PNG
(7-{17-oxa-3,4,10-triazatetracyclo[16.3.1.13,6.112,...)
Show SMILES Nc1cc(C2CCNCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434841
PNG
(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,...)
Show SMILES Nc1cc(C2CCNCc3cccc(COc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434849
PNG
(7-[(11S)-11-Methyl-18-oxa-3,4,10-triazatetracyclo[...)
Show SMILES C[C@H]1Cc2cccc(Oc3cccc(Cn4cc(cn4)C(CCN1)c1cc(N)nc4[nH]nnc14)c3)c2
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434860
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc(C2CCNCC3(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434864
PNG
(7-{15,22-Difluoro-18-oxa-3,4,10-triazatetracyclo[1...)
Show SMILES Nc1cc(C2CCNCc3ccc(F)c(COc4ccc(F)c(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434867
PNG
(7-[(17S)-18-Phenyl-16-oxa-2,8,9-triazapentacyclo[1...)
Show SMILES Nc1cc(C2CCNC34CCC(CC3)([C@H](C4)Oc3cccc(Cn4cc2cn4)c3)c2ccccc2)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434869
PNG
(7-[(18S)-19-Phenyl-17-oxa-2,8,9-triazapentacyclo[1...)
Show SMILES Nc1cc(C2CCNC34CCC(CC3)([C@H](C4)Oc3cccc(CCn4cc2cn4)c3)c2ccccc2)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434851
PNG
(7-{17-Oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,...)
Show SMILES Nc1cc(C2CCNCc3cccc(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434856
PNG
(7-{15-Fluoro-17-oxa-3,4,10-triazatetracyclo[17.3.1...)
Show SMILES Nc1cc(C2CCNCc3ccc(F)c(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434853
PNG
(US10577383, Example 11 | [(11S)-7-{5-Amino-3H-[1,2...)
Show SMILES Nc1cc(C2CCN[C@H](CO)Cc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434865
PNG
(7-[(3R,4S,6S,10S)-4-Benzyl-2-oxa-7,13,14-triazatet...)
Show SMILES Nc1cc([C@@H]2CCN[C@H]3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434866
PNG
(7-[(3R,4S,6S,10R)-4-Benzyl-2-oxa-7,13,14-triazatet...)
Show SMILES Nc1cc([C@H]2CCN[C@H]3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434870
PNG
(7-{8,9,15-triazatetracyclo[16.3.1.12,6.18,11]tetra...)
Show SMILES Nc1cc(C2CCNCCc3cccc(c3)-c3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434872
PNG
(7-[(11S,14R)-16-Oxa-3,4,10-triazatetracyclo[15.3.1...)
Show SMILES Nc1cc(C2CCN[C@H]3CC[C@H](C3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434873
PNG
(7-{5-Amino-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl}-...)
Show SMILES Nc1cc(C2CCNCC(=O)N(CCc3ccccc3)Cc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434846
PNG
(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,...)
Show SMILES Nc1cc(C2CCNCCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434849
PNG
(7-[(11S)-11-Methyl-18-oxa-3,4,10-triazatetracyclo[...)
Show SMILES C[C@H]1Cc2cccc(Oc3cccc(Cn4cc(cn4)C(CCN1)c1cc(N)nc4[nH]nnc14)c3)c2
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434865
PNG
(7-[(3R,4S,6S,10S)-4-Benzyl-2-oxa-7,13,14-triazatet...)
Show SMILES Nc1cc([C@@H]2CCN[C@H]3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434866
PNG
(7-[(3R,4S,6S,10R)-4-Benzyl-2-oxa-7,13,14-triazatet...)
Show SMILES Nc1cc([C@H]2CCN[C@H]3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434867
PNG
(7-[(17S)-18-Phenyl-16-oxa-2,8,9-triazapentacyclo[1...)
Show SMILES Nc1cc(C2CCNC34CCC(CC3)([C@H](C4)Oc3cccc(Cn4cc2cn4)c3)c2ccccc2)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434846
PNG
(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,...)
Show SMILES Nc1cc(C2CCNCCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434852
PNG
(7-[(17R)-17-Methyl-18-oxa-3,4,10-triazatetracyclo[...)
Show SMILES C[C@H]1Oc2cccc(Cn3cc(cn3)C(CCNCc3cccc1c3)c1cc(N)nc3[nH]nnc13)c2
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434854
PNG
(7-{14-Fluoro-17-oxa-3,4,10-triazatetracyclo[17.3.1...)
Show SMILES Nc1cc(C2CCNCc3cc(F)cc(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434862
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc(C2CCNCC3(CCCC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434861
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc([C@@H]2CCNCC3(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434869
PNG
(7-[(18S)-19-Phenyl-17-oxa-2,8,9-triazapentacyclo[1...)
Show SMILES Nc1cc(C2CCNC34CCC(CC3)([C@H](C4)Oc3cccc(CCn4cc2cn4)c3)c2ccccc2)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434842
PNG
(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,...)
Show SMILES Nc1cc([C@@H]2CCNCCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434850
PNG
(7-[(11R)-11-Methyl-18-oxa-3,4,10-triazatetracyclo[...)
Show SMILES C[C@@H]1Cc2cccc(Oc3cccc(Cn4cc(cn4)C(CCN1)c1cc(N)nc4[nH]nnc14)c3)c2
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434857
PNG
(7-{14-Chloro-17-oxa-3,4,10-triazatetracyclo[17.3.1...)
Show SMILES Nc1cc(C2CCNCc3cc(Cl)cc(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434858
PNG
(7-{18-Oxa-3,4,10-triazatetracyclo[18.3.1.13,6.113,...)
Show SMILES Nc1cc(C2CCNCCc3cccc(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434843
PNG
(7-{3-Oxa-10,11,17-triazatetracyclo[16.2.2.14,8.110...)
Show SMILES Nc1cc(C2CCNC3CCC(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434871
PNG
(7-[(3S,4S)-4-Benzyl-2-oxa-6,12,13-triazatetracyclo...)
Show SMILES Nc1cc(C2CCN3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434876
PNG
(7-{12,12-Difluoro-18-oxa-3,4,10-triazatetracyclo[1...)
Show SMILES Nc1cc(C2CCNCC(F)(F)c3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Eosinophil peroxidase


(Human)
BDBM434844
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc([C@H]2CCNCC3(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
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n/an/a 63n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
EPX bromination activity was measured in 100 mM KPi (pH 7.4) by monitoring the H2O2 catalyzed formation of 3-bromo tyrosine from tyrosine and potassi...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Eosinophil peroxidase


(Human)
BDBM434841
PNG
(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,...)
Show SMILES Nc1cc(C2CCNCc3cccc(COc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
EPX bromination activity was measured in 100 mM KPi (pH 7.4) by monitoring the H2O2 catalyzed formation of 3-bromo tyrosine from tyrosine and potassi...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Eosinophil peroxidase


(Human)
BDBM434843
PNG
(7-{3-Oxa-10,11,17-triazatetracyclo[16.2.2.14,8.110...)
Show SMILES Nc1cc(C2CCNC3CCC(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
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n/an/a 220n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
EPX bromination activity was measured in 100 mM KPi (pH 7.4) by monitoring the H2O2 catalyzed formation of 3-bromo tyrosine from tyrosine and potassi...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434864
PNG
(7-{15,22-Difluoro-18-oxa-3,4,10-triazatetracyclo[1...)
Show SMILES Nc1cc(C2CCNCc3ccc(F)c(COc4ccc(F)c(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434872
PNG
(7-[(11S,14R)-16-Oxa-3,4,10-triazatetracyclo[15.3.1...)
Show SMILES Nc1cc(C2CCN[C@H]3CC[C@H](C3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434861
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc([C@@H]2CCNCC3(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434843
PNG
(7-{3-Oxa-10,11,17-triazatetracyclo[16.2.2.14,8.110...)
Show SMILES Nc1cc(C2CCNC3CCC(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434852
PNG
(7-[(17R)-17-Methyl-18-oxa-3,4,10-triazatetracyclo[...)
Show SMILES C[C@H]1Oc2cccc(Cn3cc(cn3)C(CCNCc3cccc1c3)c1cc(N)nc3[nH]nnc13)c2
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434857
PNG
(7-{14-Chloro-17-oxa-3,4,10-triazatetracyclo[17.3.1...)
Show SMILES Nc1cc(C2CCNCc3cc(Cl)cc(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434841
PNG
(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,...)
Show SMILES Nc1cc(C2CCNCc3cccc(COc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434874
PNG
(7-[(12S,13R)-12-Phenyl-15-oxa-3,4,10-triazatetracy...)
Show SMILES Nc1cc(C2CCN3C[C@H](COc4cccc(Cn5cc2cn5)c4)[C@H](C3)c2ccccc2)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434873
PNG
(7-{5-Amino-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl}-...)
Show SMILES Nc1cc(C2CCNCC(=O)N(CCc3ccccc3)Cc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434871
PNG
(7-[(3S,4S)-4-Benzyl-2-oxa-6,12,13-triazatetracyclo...)
Show SMILES Nc1cc(C2CCN3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434870
PNG
(7-{8,9,15-triazatetracyclo[16.3.1.12,6.18,11]tetra...)
Show SMILES Nc1cc(C2CCNCCc3cccc(c3)-c3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434844
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc([C@H]2CCNCC3(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434860
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc(C2CCNCC3(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434853
PNG
(US10577383, Example 11 | [(11S)-7-{5-Amino-3H-[1,2...)
Show SMILES Nc1cc(C2CCN[C@H](CO)Cc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434847
PNG
(US10577383, Example 4)
Show SMILES Nc1cc([C@H]2CCNCCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434847
PNG
(US10577383, Example 4)
Show SMILES Nc1cc([C@H]2CCNCCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434877
PNG
(7-[10-(2-Methoxyethyl)-18-oxa-3,4,10-triazatetracy...)
Show SMILES COCCN1CCC(c2cnn(Cc3cccc(Oc4cccc(CC1)c4)c3)c2)c1cc(N)nc2[nH]nnc12
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434859
PNG
(7-{14-Oxa-3,4,10-triazatricyclo[13.3.1.13,6]icosa-...)
Show SMILES Nc1cc(C2CCNCCCOc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434848
PNG
(7-{10-methyl-17-oxa-3,4,10-triazatetracyclo[16.3.1...)
Show SMILES CN1CCC(c2cnn(Cc3cccc(Oc4cccc(C1)c4)c3)c2)c1cc(N)nc2[nH]nnc12
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434863
PNG
(7-[14-(Trifluoromethoxy)-18-oxa-3,4,10-triazatetra...)
Show SMILES Nc1cc(C2CCNCc3cc(COc4cccc(Cn5cc2cn5)c4)cc(OC(F)(F)F)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434858
PNG
(7-{18-Oxa-3,4,10-triazatetracyclo[18.3.1.13,6.113,...)
Show SMILES Nc1cc(C2CCNCCc3cccc(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434862
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc(C2CCNCC3(CCCC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434850
PNG
(7-[(11R)-11-Methyl-18-oxa-3,4,10-triazatetracyclo[...)
Show SMILES C[C@@H]1Cc2cccc(Oc3cccc(Cn4cc(cn4)C(CCN1)c1cc(N)nc4[nH]nnc14)c3)c2
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434855
PNG
(7-{15-Methoxy-17-oxa-3,4,10-triazatetracyclo[17.3....)
Show SMILES COc1ccc2CNCCC(c3cnn(Cc4cccc(COc1c2)c4)c3)c1cc(N)nc2[nH]nnc12
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434844
PNG
(7-{14′-Oxa-3′,4′,10′-triaz...)
Show SMILES Nc1cc([C@H]2CCNCC3(CC3)COc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434845
PNG
(7-{17-oxa-3,4,10-triazatetracyclo[16.3.1.13,6.112,...)
Show SMILES Nc1cc(C2CCNCc3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434863
PNG
(7-[14-(Trifluoromethoxy)-18-oxa-3,4,10-triazatetra...)
Show SMILES Nc1cc(C2CCNCc3cc(COc4cccc(Cn5cc2cn5)c4)cc(OC(F)(F)F)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434877
PNG
(7-[10-(2-Methoxyethyl)-18-oxa-3,4,10-triazatetracy...)
Show SMILES COCCN1CCC(c2cnn(Cc3cccc(Oc4cccc(CC1)c4)c3)c2)c1cc(N)nc2[nH]nnc12
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434875
PNG
(2-(7-{15-Amino-3H-[1,2,3]triazolo[4,5-b]pyridin-7-...)
Show SMILES NC(=O)CN1CCC(c2cnn(Cc3cccc(Oc4cccc(CC1)c4)c3)c2)c1cc(N)nc2[nH]nnc12
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434859
PNG
(7-{14-Oxa-3,4,10-triazatricyclo[13.3.1.13,6]icosa-...)
Show SMILES Nc1cc(C2CCNCCCOc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434855
PNG
(7-{15-Methoxy-17-oxa-3,4,10-triazatetracyclo[17.3....)
Show SMILES COc1ccc2CNCCC(c3cnn(Cc4cccc(COc1c2)c4)c3)c1cc(N)nc2[nH]nnc12
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434875
PNG
(2-(7-{15-Amino-3H-[1,2,3]triazolo[4,5-b]pyridin-7-...)
Show SMILES NC(=O)CN1CCC(c2cnn(Cc3cccc(Oc4cccc(CC1)c4)c3)c2)c1cc(N)nc2[nH]nnc12
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434868
PNG
(7-[(17R)-18-Phenyl-16-oxa-2,8,9-triazapentacyclo[1...)
Show SMILES Nc1cc(C2CCNC34CCC(CC3)([C@@H](C4)Oc3cccc(Cn4cc2cn4)c3)c2ccccc2)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434876
PNG
(7-{12,12-Difluoro-18-oxa-3,4,10-triazatetracyclo[1...)
Show SMILES Nc1cc(C2CCNCC(F)(F)c3cccc(Oc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434848
PNG
(7-{10-methyl-17-oxa-3,4,10-triazatetracyclo[16.3.1...)
Show SMILES CN1CCC(c2cnn(Cc3cccc(Oc4cccc(C1)c4)c3)c2)c1cc(N)nc2[nH]nnc12
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434856
PNG
(7-{15-Fluoro-17-oxa-3,4,10-triazatetracyclo[17.3.1...)
Show SMILES Nc1cc(C2CCNCc3ccc(F)c(OCc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
Myeloperoxidase


(Homo sapiens (Human))
BDBM434874
PNG
(7-[(12S,13R)-12-Phenyl-15-oxa-3,4,10-triazatetracy...)
Show SMILES Nc1cc(C2CCN3C[C@H](COc4cccc(Cn5cc2cn5)c4)[C@H](C3)c2ccccc2)c2nn[nH]c2n1
PDB
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Bristol-Myers Squibb Company

US Patent


Assay Description
MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...


US Patent US10577383 (2020)


BindingDB Entry DOI: 10.7270/Q2474D8B
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%