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Patent code US10583137

Compile Data Set for Download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434887
PNG
((2-benzylpiperidin-1-yl)(4-(2',4'- dimethoxy-[1,1'...)
Show SMILES COc1ccc(c(OC)c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C29H30N4O3/c1-35-25-15-16-26(28(19-25)36-2)22-11-13-23(14-12-22)27-20-33(31-30-27)29(34)32-17-7-6-10-24(32)18-21-8-4-3-5-9-21/h3-5,8-9,11-16,19-20,24H,6-7,10,17-18H2,1-2H3
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n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434927
PNG
(N-cyclobutyl-N-phenethyl-4-(4- (trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cn(nn1)C(=O)N(CCc1ccccc1)C1CCC1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-19-11-9-17(10-12-19)20-15-29(27-26-20)21(30)28(18-7-4-8-18)14-13-16-5-2-1-3-6-16/h1-3,5-6,9-12,15,18H,4,7-8,13-14H2
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n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434920
PNG
((2-benzylpiperidin-1-yl)(4-(6- bromopyridin-3-yl)-...)
Show SMILES Brc1ccc(cn1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C20H20BrN5O/c21-19-10-9-16(13-22-19)18-14-26(24-23-18)20(27)25-11-5-4-8-17(25)12-15-6-2-1-3-7-15/h1-3,6-7,9-10,13-14,17H,4-5,8,11-12H2
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n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434924
PNG
((2-benzylpiperidin-1-yl)(4-(4- (morpholinomethyl)p...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C26H31N5O2/c32-26(30-13-5-4-8-24(30)18-21-6-2-1-3-7-21)31-20-25(27-28-31)23-11-9-22(10-12-23)19-29-14-16-33-17-15-29/h1-3,6-7,9-12,20,24H,4-5,8,13-19H2
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n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434925
PNG
(N-(2-ethylbutyl)-N-phenethyl-4- (4-(trifluorometho...)
Show SMILES CCC(CC)CN(CCc1ccccc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C24H27F3N4O2/c1-3-18(4-2)16-30(15-14-19-8-6-5-7-9-19)23(32)31-17-22(28-29-31)20-10-12-21(13-11-20)33-24(25,26)27/h5-13,17-18H,3-4,14-16H2,1-2H3
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n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM50211257
PNG
(CHEMBL3895863 | US10583137, Compound 14)
Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1
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US Patent
n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434879
PNG
(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Show SMILES CC(C)(C)OC(=O)N1CCN(C(Cc2ccccc2)C1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C26H28F3N5O4/c1-25(2,3)38-24(36)32-13-14-33(20(16-32)15-18-7-5-4-6-8-18)23(35)34-17-22(30-31-34)19-9-11-21(12-10-19)37-26(27,28)29/h4-12,17,20H,13-16H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434880
PNG
((2-Benzylpiperidin-1-yl)(4-(4-(3,5-dimethoxypyridi...)
Show SMILES COc1cncc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-35-25-17-29-18-26(36-2)27(25)22-13-11-21(12-14-22)24-19-33(31-30-24)28(34)32-15-7-6-10-23(32)16-20-8-4-3-5-9-20/h3-5,8-9,11-14,17-19,23H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434881
PNG
((2-Benzylpiperidin-1-yl)(4-(2′,4′,6...)
Show SMILES COc1cc(OC)c(c(OC)c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H32N4O4/c1-36-25-18-27(37-2)29(28(19-25)38-3)23-14-12-22(13-15-23)26-20-34(32-31-26)30(35)33-16-8-7-11-24(33)17-21-9-5-4-6-10-21/h4-6,9-10,12-15,18-20,24H,7-8,11,16-17H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434892
PNG
((4-([1,1'-biphenyl]-4-yl)-1H- 1,2,3-triazol-1-yl)(...)
Show SMILES O=C(N1CCCCC1Cc1ccncc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H25N5O/c32-26(30-17-5-4-8-24(30)18-20-13-15-27-16-14-20)31-19-25(28-29-31)23-11-9-22(10-12-23)21-6-2-1-3-7-21/h1-3,6-7,9-16,19,24H,4-5,8,17-18H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434900
PNG
((2-benzylpiperidin-1-yl)(4-(6- (2,4,6- trimethoxyp...)
Show SMILES COc1cc(OC)c(c(OC)c1)-c1ccc(cn1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C29H31N5O4/c1-36-23-16-26(37-2)28(27(17-23)38-3)24-13-12-21(18-30-24)25-19-34(32-31-25)29(35)33-14-8-7-11-22(33)15-20-9-5-4-6-10-20/h4-6,9-10,12-13,16-19,22H,7-8,11,14-15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434929
PNG
(N-(2-ethylbutyl)-N-phenethyl-4- (4-(trifluorometho...)
Show SMILES CCC(CC)CN(CCc1ccccc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C24H27F3N4O2/c1-3-18(4-2)17-30(15-14-19-8-6-5-7-9-19)23(32)31-28-16-22(29-31)20-10-12-21(13-11-20)33-24(25,26)27/h5-13,16,18H,3-4,14-15,17H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434937
PNG
(N-neopentyl-N-(2-(pyridin-3- yl)ethyl)-4-(4- (trif...)
Show SMILES CC(C)(C)CN(CCc1cccnc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2,3)15-29(12-10-16-5-4-11-26-13-16)20(31)30-14-19(27-28-30)17-6-8-18(9-7-17)32-22(23,24)25/h4-9,11,13-14H,10,12,15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434939
PNG
(N-(2-ethylbutyl)-N-(2-(pyridin- 3-yl)ethyl)-4-(4- ...)
Show SMILES CCC(CC)CN(CCc1cccnc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H26F3N5O2/c1-3-17(4-2)15-30(13-11-18-6-5-12-27-14-18)22(32)31-16-21(28-29-31)19-7-9-20(10-8-19)33-23(24,25)26/h5-10,12,14,16-17H,3-4,11,13,15H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434894
PNG
((4-(2',6'-dimethoxy-4'-methyl- [1,1'-biphenyl]-4-y...)
Show SMILES COc1cc(C)cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccncc1
Show InChI InChI=1S/C29H31N5O3/c1-20-16-26(36-2)28(27(17-20)37-3)23-9-7-22(8-10-23)25-19-34(32-31-25)29(35)33-15-5-4-6-24(33)18-21-11-13-30-14-12-21/h7-14,16-17,19,24H,4-6,15,18H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434899
PNG
((2-benzylpiperidin-1-yl)(4-(4- (3,5-dichloropyridi...)
Show SMILES Clc1cncc(Cl)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C26H23Cl2N5O/c27-22-15-29-16-23(28)25(22)20-11-9-19(10-12-20)24-17-33(31-30-24)26(34)32-13-5-4-8-21(32)14-18-6-2-1-3-7-18/h1-3,6-7,9-12,15-17,21H,4-5,8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434903
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES CN(C)C(=O)c1ccccc1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-33(2)29(36)27-14-7-6-13-26(27)23-15-17-24(18-16-23)28-21-35(32-31-28)30(37)34-19-9-8-12-25(34)20-22-10-4-3-5-11-22/h3-7,10-11,13-18,21,25H,8-9,12,19-20H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434921
PNG
(4-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tri...)
Show SMILES CS(=O)(=O)OCc1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C23H26N4O4S/c1-32(29,30)31-17-19-10-12-20(13-11-19)22-16-27(25-24-22)23(28)26-14-6-5-9-21(26)15-18-7-3-2-4-8-18/h2-4,7-8,10-13,16,21H,5-6,9,14-15,17H2,1H3
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n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434925
PNG
(N-(2-ethylbutyl)-N-phenethyl-4- (4-(trifluorometho...)
Show SMILES CCC(CC)CN(CCc1ccccc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C24H27F3N4O2/c1-3-18(4-2)16-30(15-14-19-8-6-5-7-9-19)23(32)31-17-22(28-29-31)20-10-12-21(13-11-20)33-24(25,26)27/h5-13,17-18H,3-4,14-16H2,1-2H3
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n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434930
PNG
(N-neopentyl-N-phenethyl-4-(4- (trifluoromethoxy)ph...)
Show SMILES CC(C)(C)CN(CCc1ccccc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N4O2/c1-22(2,3)16-29(14-13-17-7-5-4-6-8-17)21(31)30-27-15-20(28-30)18-9-11-19(12-10-18)32-23(24,25)26/h4-12,15H,13-14,16H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434885
PNG
((2-benzylpiperidin-1-yl)(4-(4- (pyridin-3-yl)pheny...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C26H25N5O/c32-26(30-16-5-4-10-24(30)17-20-7-2-1-3-8-20)31-19-25(28-29-31)22-13-11-21(12-14-22)23-9-6-15-27-18-23/h1-3,6-9,11-15,18-19,24H,4-5,10,16-17H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434892
PNG
((4-([1,1'-biphenyl]-4-yl)-1H- 1,2,3-triazol-1-yl)(...)
Show SMILES O=C(N1CCCCC1Cc1ccncc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H25N5O/c32-26(30-17-5-4-8-24(30)18-20-13-15-27-16-14-20)31-19-25(28-29-31)23-11-9-22(10-12-23)21-6-2-1-3-7-21/h1-3,6-7,9-16,19,24H,4-5,8,17-18H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434909
PNG
((2-benzylpiperidin-1-yl)(4-(4- (3,5-dimethoxypyrid...)
Show SMILES COc1cnnc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-35-24-17-28-30-26(36-2)25(24)21-13-11-20(12-14-21)23-18-33(31-29-23)27(34)32-15-7-6-10-22(32)16-19-8-4-3-5-9-19/h3-5,8-9,11-14,17-18,22H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434928
PNG
(N-cyclopropyl-N-phenethyl-4- (4-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cn(nn1)C(=O)N(CCc1ccccc1)C1CC1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)30-18-10-6-16(7-11-18)19-14-28(26-25-19)20(29)27(17-8-9-17)13-12-15-4-2-1-3-5-15/h1-7,10-11,14,17H,8-9,12-13H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434933
PNG
(N-(cyclopropylmethyl)-N- phenethyl-4-(4- (trifluor...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cn(nn1)C(=O)N(CCc1ccccc1)CC1CC1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-19-10-8-18(9-11-19)20-15-29(27-26-20)21(30)28(14-17-6-7-17)13-12-16-4-2-1-3-5-16/h1-5,8-11,15,17H,6-7,12-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434879
PNG
(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Show SMILES CC(C)(C)OC(=O)N1CCN(C(Cc2ccccc2)C1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C26H28F3N5O4/c1-25(2,3)38-24(36)32-13-14-33(20(16-32)15-18-7-5-4-6-8-18)23(35)34-17-22(30-31-34)19-9-11-21(12-10-19)37-26(27,28)29/h4-12,17,20H,13-16H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434880
PNG
((2-Benzylpiperidin-1-yl)(4-(4-(3,5-dimethoxypyridi...)
Show SMILES COc1cncc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-35-25-17-29-18-26(36-2)27(25)22-13-11-21(12-14-22)24-19-33(31-30-24)28(34)32-15-7-6-10-23(32)16-20-8-4-3-5-9-20/h3-5,8-9,11-14,17-19,23H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434899
PNG
((2-benzylpiperidin-1-yl)(4-(4- (3,5-dichloropyridi...)
Show SMILES Clc1cncc(Cl)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C26H23Cl2N5O/c27-22-15-29-16-23(28)25(22)20-11-9-19(10-12-20)24-17-33(31-30-24)26(34)32-13-5-4-8-21(32)14-18-6-2-1-3-7-18/h1-3,6-7,9-12,15-17,21H,4-5,8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434908
PNG
((2-benzylpiperidin-1-yl)(4-(4- (4,6-dimethoxypyrim...)
Show SMILES COc1ncnc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-35-25-24(26(36-2)29-18-28-25)21-13-11-20(12-14-21)23-17-33(31-30-23)27(34)32-15-7-6-10-22(32)16-19-8-4-3-5-9-19/h3-5,8-9,11-14,17-18,22H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434908
PNG
((2-benzylpiperidin-1-yl)(4-(4- (4,6-dimethoxypyrim...)
Show SMILES COc1ncnc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-35-25-24(26(36-2)29-18-28-25)21-13-11-20(12-14-21)23-17-33(31-30-23)27(34)32-15-7-6-10-22(32)16-19-8-4-3-5-9-19/h3-5,8-9,11-14,17-18,22H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434908
PNG
((2-benzylpiperidin-1-yl)(4-(4- (4,6-dimethoxypyrim...)
Show SMILES COc1ncnc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-35-25-24(26(36-2)29-18-28-25)21-13-11-20(12-14-21)23-17-33(31-30-23)27(34)32-15-7-6-10-22(32)16-19-8-4-3-5-9-19/h3-5,8-9,11-14,17-18,22H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434918
PNG
(4-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tri...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H21N5O/c23-15-18-9-11-19(12-10-18)21-16-27(25-24-21)22(28)26-13-5-4-8-20(26)14-17-6-2-1-3-7-17/h1-3,6-7,9-12,16,20H,4-5,8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434918
PNG
(4-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tri...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H21N5O/c23-15-18-9-11-19(12-10-18)21-16-27(25-24-21)22(28)26-13-5-4-8-20(26)14-17-6-2-1-3-7-17/h1-3,6-7,9-12,16,20H,4-5,8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434919
PNG
((2-benzylpiperidin-1-yl)(4-(4- nitrophenyl)-1H-1,2...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C21H21N5O3/c27-21(24-13-5-4-8-19(24)14-16-6-2-1-3-7-16)25-15-20(22-23-25)17-9-11-18(12-10-17)26(28)29/h1-3,6-7,9-12,15,19H,4-5,8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434926
PNG
(N-neopentyl-N-phenethyl-4-(4- (trifluoromethoxy)ph...)
Show SMILES CC(C)(C)CN(CCc1ccccc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N4O2/c1-22(2,3)16-29(14-13-17-7-5-4-6-8-17)21(31)30-15-20(27-28-30)18-9-11-19(12-10-18)32-23(24,25)26/h4-12,15H,13-14,16H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434928
PNG
(N-cyclopropyl-N-phenethyl-4- (4-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cn(nn1)C(=O)N(CCc1ccccc1)C1CC1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)30-18-10-6-16(7-11-18)19-14-28(26-25-19)20(29)27(17-8-9-17)13-12-15-4-2-1-3-5-15/h1-7,10-11,14,17H,8-9,12-13H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434935
PNG
(N-neopentyl-N-(2-(pyridin-4- yl)ethyl)-4-(4- (trif...)
Show SMILES CC(C)(C)CN(CCc1ccncc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2,3)15-29(13-10-16-8-11-26-12-9-16)20(31)30-14-19(27-28-30)17-4-6-18(7-5-17)32-22(23,24)25/h4-9,11-12,14H,10,13,15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434889
PNG
((2-benzylpiperidin-1-yl)(4-(2',6'- dimethoxy-[1,1'...)
Show SMILES COc1cccc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C29H30N4O3/c1-35-26-12-8-13-27(36-2)28(26)23-16-14-22(15-17-23)25-20-33(31-30-25)29(34)32-18-7-6-11-24(32)19-21-9-4-3-5-10-21/h3-5,8-10,12-17,20,24H,6-7,11,18-19H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434919
PNG
((2-benzylpiperidin-1-yl)(4-(4- nitrophenyl)-1H-1,2...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C21H21N5O3/c27-21(24-13-5-4-8-19(24)14-16-6-2-1-3-7-16)25-15-20(22-23-25)17-9-11-18(12-10-17)26(28)29/h1-3,6-7,9-12,15,19H,4-5,8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434926
PNG
(N-neopentyl-N-phenethyl-4-(4- (trifluoromethoxy)ph...)
Show SMILES CC(C)(C)CN(CCc1ccccc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N4O2/c1-22(2,3)16-29(14-13-17-7-5-4-6-8-17)21(31)30-15-20(27-28-30)18-9-11-19(12-10-18)32-23(24,25)26/h4-12,15H,13-14,16H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434927
PNG
(N-cyclobutyl-N-phenethyl-4-(4- (trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cn(nn1)C(=O)N(CCc1ccccc1)C1CCC1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-19-11-9-17(10-12-19)20-15-29(27-26-20)21(30)28(18-7-4-8-18)14-13-16-5-2-1-3-6-16/h1-3,5-6,9-12,15,18H,4,7-8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434933
PNG
(N-(cyclopropylmethyl)-N- phenethyl-4-(4- (trifluor...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cn(nn1)C(=O)N(CCc1ccccc1)CC1CC1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-19-10-8-18(9-11-19)20-15-29(27-26-20)21(30)28(14-17-6-7-17)13-12-16-4-2-1-3-5-16/h1-5,8-11,15,17H,6-7,12-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434937
PNG
(N-neopentyl-N-(2-(pyridin-3- yl)ethyl)-4-(4- (trif...)
Show SMILES CC(C)(C)CN(CCc1cccnc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2,3)15-29(12-10-16-5-4-11-26-13-16)20(31)30-14-19(27-28-30)17-6-8-18(9-7-17)32-22(23,24)25/h4-9,11,13-14H,10,12,15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434881
PNG
((2-Benzylpiperidin-1-yl)(4-(2′,4′,6...)
Show SMILES COc1cc(OC)c(c(OC)c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H32N4O4/c1-36-25-18-27(37-2)29(28(19-25)38-3)23-14-12-22(13-15-23)26-20-34(32-31-26)30(35)33-16-8-7-11-24(33)17-21-9-5-4-6-10-21/h4-6,9-10,12-15,18-20,24H,7-8,11,16-17H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434890
PNG
((2-benzylpiperidin-1-yl)(4-(2',6'- dimethoxy-4'-me...)
Show SMILES COc1cc(C)cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H32N4O3/c1-21-17-27(36-2)29(28(18-21)37-3)24-14-12-23(13-15-24)26-20-34(32-31-26)30(35)33-16-8-7-11-25(33)19-22-9-5-4-6-10-22/h4-6,9-10,12-15,17-18,20,25H,7-8,11,16,19H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434895
PNG
((4-(4'-chloro-2',6'-dimethoxy- [1,1'-biphenyl]-4-y...)
Show SMILES COc1cc(Cl)cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccncc1
Show InChI InChI=1S/C28H28ClN5O3/c1-36-25-16-22(29)17-26(37-2)27(25)21-8-6-20(7-9-21)24-18-34(32-31-24)28(35)33-14-4-3-5-23(33)15-19-10-12-30-13-11-19/h6-13,16-18,23H,3-5,14-15H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434908
PNG
((2-benzylpiperidin-1-yl)(4-(4- (4,6-dimethoxypyrim...)
Show SMILES COc1ncnc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-35-25-24(26(36-2)29-18-28-25)21-13-11-20(12-14-21)23-17-33(31-30-23)27(34)32-15-7-6-10-22(32)16-19-8-4-3-5-9-19/h3-5,8-9,11-14,17-18,22H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434913
PNG
((2-benzylpiperidin-1-yl)(4-(4- methoxyphenyl)-1H-1...)
Show SMILES COc1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C22H24N4O2/c1-28-20-12-10-18(11-13-20)21-16-26(24-23-21)22(27)25-14-6-5-9-19(25)15-17-7-3-2-4-8-17/h2-4,7-8,10-13,16,19H,5-6,9,14-15H2,1H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434935
PNG
(N-neopentyl-N-(2-(pyridin-4- yl)ethyl)-4-(4- (trif...)
Show SMILES CC(C)(C)CN(CCc1ccncc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2,3)15-29(13-10-16-8-11-26-12-9-16)20(31)30-14-19(27-28-30)17-4-6-18(7-5-17)32-22(23,24)25/h4-9,11-12,14H,10,13,15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434939
PNG
(N-(2-ethylbutyl)-N-(2-(pyridin- 3-yl)ethyl)-4-(4- ...)
Show SMILES CCC(CC)CN(CCc1cccnc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H26F3N5O2/c1-3-17(4-2)15-30(13-11-18-6-5-12-27-14-18)22(32)31-16-21(28-29-31)19-7-9-20(10-8-19)33-23(24,25)26/h5-10,12,14,16-17H,3-4,11,13,15H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM50211257
PNG
(CHEMBL3895863 | US10583137, Compound 14)
Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1
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n/an/a<400n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434880
PNG
((2-Benzylpiperidin-1-yl)(4-(4-(3,5-dimethoxypyridi...)
Show SMILES COc1cncc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-35-25-17-29-18-26(36-2)27(25)22-13-11-21(12-14-22)24-19-33(31-30-24)28(34)32-15-7-6-10-23(32)16-20-8-4-3-5-9-20/h3-5,8-9,11-14,17-19,23H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434882
PNG
(N-(2-Ethylbutyl)-N-(2-(pyridin-4-yl)ethyl)-4-(4-(t...)
Show SMILES CCC(CC)CN(CCc1ccncc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H26F3N5O2/c1-3-17(4-2)15-30(14-11-18-9-12-27-13-10-18)22(32)31-16-21(28-29-31)19-5-7-20(8-6-19)33-23(24,25)26/h5-10,12-13,16-17H,3-4,11,14-15H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434913
PNG
((2-benzylpiperidin-1-yl)(4-(4- methoxyphenyl)-1H-1...)
Show SMILES COc1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C22H24N4O2/c1-28-20-12-10-18(11-13-20)21-16-26(24-23-21)22(27)25-14-6-5-9-19(25)15-17-7-3-2-4-8-17/h2-4,7-8,10-13,16,19H,5-6,9,14-15H2,1H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434920
PNG
((2-benzylpiperidin-1-yl)(4-(6- bromopyridin-3-yl)-...)
Show SMILES Brc1ccc(cn1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C20H20BrN5O/c21-19-10-9-16(13-22-19)18-14-26(24-23-18)20(27)25-11-5-4-8-17(25)12-15-6-2-1-3-7-15/h1-3,6-7,9-10,13-14,17H,4-5,8,11-12H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434893
PNG
((2-(pyridin-4- ylmethyl)piperidin-1-yl)(4- (2',4',...)
Show SMILES COc1cc(OC)c(c(OC)c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccncc1
Show InChI InChI=1S/C29H31N5O4/c1-36-24-17-26(37-2)28(27(18-24)38-3)22-9-7-21(8-10-22)25-19-34(32-31-25)29(35)33-15-5-4-6-23(33)16-20-11-13-30-14-12-20/h7-14,17-19,23H,4-6,15-16H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434886
PNG
((2-benzylpiperidin-1-yl)(4-(4- (pyridin-2-yl)pheny...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C26H25N5O/c32-26(30-17-7-5-10-23(30)18-20-8-2-1-3-9-20)31-19-25(28-29-31)22-14-12-21(13-15-22)24-11-4-6-16-27-24/h1-4,6,8-9,11-16,19,23H,5,7,10,17-18H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434902
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-33(2)29(36)26-12-8-11-25(20-26)23-14-16-24(17-15-23)28-21-35(32-31-28)30(37)34-18-7-6-13-27(34)19-22-9-4-3-5-10-22/h3-5,8-12,14-17,20-21,27H,6-7,13,18-19H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434931
PNG
(N-cyclobutyl-N-phenethyl-4-(4- (trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CCC1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-19-11-9-17(10-12-19)20-15-26-29(27-20)21(30)28(18-7-4-8-18)14-13-16-5-2-1-3-6-16/h1-3,5-6,9-12,15,18H,4,7-8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434891
PNG
((2-benzylpiperidin-1-yl)(4-(4-(3- methoxypyridin-4...)
Show SMILES COc1cnccc1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C27H27N5O2/c1-34-26-18-28-15-14-24(26)21-10-12-22(13-11-21)25-19-32(30-29-25)27(33)31-16-6-5-9-23(31)17-20-7-3-2-4-8-20/h2-4,7-8,10-15,18-19,23H,5-6,9,16-17H2,1H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434898
PNG
((2-benzylpiperidin-1-yl)(4-(4- (3,5-difluoropyridi...)
Show SMILES Fc1cncc(F)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C26H23F2N5O/c27-22-15-29-16-23(28)25(22)20-11-9-19(10-12-20)24-17-33(31-30-24)26(34)32-13-5-4-8-21(32)14-18-6-2-1-3-7-18/h1-3,6-7,9-12,15-17,21H,4-5,8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434906
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES COc1cc(cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1)C(=O)N(C)C
Show InChI InChI=1S/C32H35N5O4/c1-35(2)31(38)25-19-28(40-3)30(29(20-25)41-4)24-15-13-23(14-16-24)27-21-37(34-33-27)32(39)36-17-9-8-12-26(36)18-22-10-6-5-7-11-22/h5-7,10-11,13-16,19-21,26H,8-9,12,17-18H2,1-4H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434907
PNG
((2-benzylpiperidin-1-yl)(4-(2',6'- dimethoxy-4'-(p...)
Show SMILES COc1cc(cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1)C(=O)N1CCCC1
Show InChI InChI=1S/C34H37N5O4/c1-42-30-21-27(33(40)37-17-8-9-18-37)22-31(43-2)32(30)26-15-13-25(14-16-26)29-23-39(36-35-29)34(41)38-19-7-6-12-28(38)20-24-10-4-3-5-11-24/h3-5,10-11,13-16,21-23,28H,6-9,12,17-20H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434936
PNG
(N-neopentyl-N-(2-(pyridin-4- yl)ethyl)-4-(4- (trif...)
Show SMILES CC(C)(C)CN(CCc1ccncc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2,3)15-29(13-10-16-8-11-26-12-9-16)20(31)30-27-14-19(28-30)17-4-6-18(7-5-17)32-22(23,24)25/h4-9,11-12,14H,10,13,15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434880
PNG
((2-Benzylpiperidin-1-yl)(4-(4-(3,5-dimethoxypyridi...)
Show SMILES COc1cncc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-35-25-17-29-18-26(36-2)27(25)22-13-11-21(12-14-22)24-19-33(31-30-24)28(34)32-15-7-6-10-23(32)16-20-8-4-3-5-9-20/h3-5,8-9,11-14,17-19,23H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434924
PNG
((2-benzylpiperidin-1-yl)(4-(4- (morpholinomethyl)p...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C26H31N5O2/c32-26(30-13-5-4-8-24(30)18-21-6-2-1-3-7-21)31-20-25(27-28-31)23-11-9-22(10-12-23)19-29-14-16-33-17-15-29/h1-3,6-7,9-12,20,24H,4-5,8,13-19H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434903
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES CN(C)C(=O)c1ccccc1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-33(2)29(36)27-14-7-6-13-26(27)23-15-17-24(18-16-23)28-21-35(32-31-28)30(37)34-19-9-8-12-25(34)20-22-10-4-3-5-11-22/h3-7,10-11,13-18,21,25H,8-9,12,19-20H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434932
PNG
(N-cyclopropyl-N-phenethyl-4- (4-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CC1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)30-18-10-6-16(7-11-18)19-14-25-28(26-19)20(29)27(17-8-9-17)13-12-15-4-2-1-3-5-15/h1-7,10-11,14,17H,8-9,12-13H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434938
PNG
(N-neopentyl-N-(2-(pyridin-3- yl)ethyl)-4-(4- (trif...)
Show SMILES CC(C)(C)CN(CCc1cccnc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2,3)15-29(12-10-16-5-4-11-26-13-16)20(31)30-27-14-19(28-30)17-6-8-18(9-7-17)32-22(23,24)25/h4-9,11,13-14H,10,12,15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434882
PNG
(N-(2-Ethylbutyl)-N-(2-(pyridin-4-yl)ethyl)-4-(4-(t...)
Show SMILES CCC(CC)CN(CCc1ccncc1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H26F3N5O2/c1-3-17(4-2)15-30(14-11-18-9-12-27-13-10-18)22(32)31-16-21(28-29-31)19-5-7-20(8-6-19)33-23(24,25)26/h5-10,12-13,16-17H,3-4,11,14-15H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434905
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES CNC(=O)c1cc(OC)c(c(OC)c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C31H33N5O4/c1-32-30(37)24-18-27(39-2)29(28(19-24)40-3)23-14-12-22(13-15-23)26-20-36(34-33-26)31(38)35-16-8-7-11-25(35)17-21-9-5-4-6-10-21/h4-6,9-10,12-15,18-20,25H,7-8,11,16-17H2,1-3H3,(H,32,37)
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434934
PNG
(N-(cyclopropylmethyl)-N- phenethyl-4-(4- (trifluor...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)CC1CC1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-19-10-8-18(9-11-19)20-14-26-29(27-20)21(30)28(15-17-6-7-17)13-12-16-4-2-1-3-5-16/h1-5,8-11,14,17H,6-7,12-13,15H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434940
PNG
(US10583137, Compound 137)
Show SMILES CCC(CC)CN(CCc1cccnc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H26F3N5O2/c1-3-17(4-2)16-30(13-11-18-6-5-12-27-14-18)22(32)31-28-15-21(29-31)19-7-9-20(10-8-19)33-23(24,25)26/h5-10,12,14-15,17H,3-4,11,13,16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434884
PNG
((2-benzylpiperidin-1-yl)(4-(4- (pyridin-4-yl)pheny...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C26H25N5O/c32-26(30-17-5-4-8-24(30)18-20-6-2-1-3-7-20)31-19-25(28-29-31)23-11-9-21(10-12-23)22-13-15-27-16-14-22/h1-3,6-7,9-16,19,24H,4-5,8,17-18H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434898
PNG
((2-benzylpiperidin-1-yl)(4-(4- (3,5-difluoropyridi...)
Show SMILES Fc1cncc(F)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C26H23F2N5O/c27-22-15-29-16-23(28)25(22)20-11-9-19(10-12-20)24-17-33(31-30-24)26(34)32-13-5-4-8-21(32)14-18-6-2-1-3-7-18/h1-3,6-7,9-12,15-17,21H,4-5,8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434904
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES COc1cc(cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H31N5O4/c1-38-26-17-23(29(31)36)18-27(39-2)28(26)22-13-11-21(12-14-22)25-19-35(33-32-25)30(37)34-15-7-6-10-24(34)16-20-8-4-3-5-9-20/h3-5,8-9,11-14,17-19,24H,6-7,10,15-16H2,1-2H3,(H2,31,36)
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434940
PNG
(US10583137, Compound 137)
Show SMILES CCC(CC)CN(CCc1cccnc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H26F3N5O2/c1-3-17(4-2)16-30(13-11-18-6-5-12-27-14-18)22(32)31-28-15-21(29-31)19-7-9-20(10-8-19)33-23(24,25)26/h5-10,12,14-15,17H,3-4,11,13,16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434886
PNG
((2-benzylpiperidin-1-yl)(4-(4- (pyridin-2-yl)pheny...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C26H25N5O/c32-26(30-17-7-5-10-23(30)18-20-8-2-1-3-9-20)31-19-25(28-29-31)22-14-12-21(13-15-22)24-11-4-6-16-27-24/h1-4,6,8-9,11-16,19,23H,5,7,10,17-18H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434910
PNG
((2-benzylpiperidin-1-yl)(4- (2,4,6-trimethoxypheny...)
Show SMILES COc1cc(OC)c(-c2cn(nn2)C(=O)N2CCCCC2Cc2ccccc2)c(OC)c1
Show InChI InChI=1S/C24H28N4O4/c1-30-19-14-21(31-2)23(22(15-19)32-3)20-16-28(26-25-20)24(29)27-12-8-7-11-18(27)13-17-9-5-4-6-10-17/h4-6,9-10,14-16,18H,7-8,11-13H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434893
PNG
((2-(pyridin-4- ylmethyl)piperidin-1-yl)(4- (2',4',...)
Show SMILES COc1cc(OC)c(c(OC)c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccncc1
Show InChI InChI=1S/C29H31N5O4/c1-36-24-17-26(37-2)28(27(18-24)38-3)22-9-7-21(8-10-22)25-19-34(32-31-25)29(35)33-15-5-4-6-23(33)16-20-11-13-30-14-12-20/h7-14,17-19,23H,4-6,15-16H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434932
PNG
(N-cyclopropyl-N-phenethyl-4- (4-(trifluoromethoxy)...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CC1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)30-18-10-6-16(7-11-18)19-14-25-28(26-19)20(29)27(17-8-9-17)13-12-15-4-2-1-3-5-15/h1-7,10-11,14,17H,8-9,12-13H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434934
PNG
(N-(cyclopropylmethyl)-N- phenethyl-4-(4- (trifluor...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)CC1CC1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-19-10-8-18(9-11-19)20-14-26-29(27-20)21(30)28(15-17-6-7-17)13-12-16-4-2-1-3-5-16/h1-5,8-11,14,17H,6-7,12-13,15H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434891
PNG
((2-benzylpiperidin-1-yl)(4-(4-(3- methoxypyridin-4...)
Show SMILES COc1cnccc1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C27H27N5O2/c1-34-26-18-28-15-14-24(26)21-10-12-22(13-11-21)25-19-32(30-29-25)27(33)31-16-6-5-9-23(31)17-20-7-3-2-4-8-20/h2-4,7-8,10-15,18-19,23H,5-6,9,16-17H2,1H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434895
PNG
((4-(4'-chloro-2',6'-dimethoxy- [1,1'-biphenyl]-4-y...)
Show SMILES COc1cc(Cl)cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccncc1
Show InChI InChI=1S/C28H28ClN5O3/c1-36-25-16-22(29)17-26(37-2)27(25)21-8-6-20(7-9-21)24-18-34(32-31-24)28(35)33-14-4-3-5-23(33)15-19-10-12-30-13-11-19/h6-13,16-18,23H,3-5,14-15H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434900
PNG
((2-benzylpiperidin-1-yl)(4-(6- (2,4,6- trimethoxyp...)
Show SMILES COc1cc(OC)c(c(OC)c1)-c1ccc(cn1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C29H31N5O4/c1-36-23-16-26(37-2)28(27(17-23)38-3)24-13-12-21(18-30-24)25-19-34(32-31-25)29(35)33-14-8-7-11-22(33)15-20-9-5-4-6-10-20/h4-6,9-10,12-13,16-19,22H,7-8,11,14-15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434909
PNG
((2-benzylpiperidin-1-yl)(4-(4- (3,5-dimethoxypyrid...)
Show SMILES COc1cnnc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-35-24-17-28-30-26(36-2)25(24)21-13-11-20(12-14-21)23-18-33(31-29-23)27(34)32-15-7-6-10-22(32)16-19-8-4-3-5-9-19/h3-5,8-9,11-14,17-18,22H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434889
PNG
((2-benzylpiperidin-1-yl)(4-(2',6'- dimethoxy-[1,1'...)
Show SMILES COc1cccc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C29H30N4O3/c1-35-26-12-8-13-27(36-2)28(26)23-16-14-22(15-17-23)25-20-33(31-30-25)29(34)32-18-7-6-11-24(32)19-21-9-4-3-5-10-21/h3-5,8-10,12-17,20,24H,6-7,11,18-19H2,1-2H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434930
PNG
(N-neopentyl-N-phenethyl-4-(4- (trifluoromethoxy)ph...)
Show SMILES CC(C)(C)CN(CCc1ccccc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N4O2/c1-22(2,3)16-29(14-13-17-7-5-4-6-8-17)21(31)30-27-15-20(28-30)18-9-11-19(12-10-18)32-23(24,25)26/h4-12,15H,13-14,16H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434911
PNG
((2-benzylpiperidin-1-yl)(4- (2,4,6-trimethoxypheny...)
Show SMILES COc1cc(OC)c(-c2cnn(n2)C(=O)N2CCCCC2Cc2ccccc2)c(OC)c1
Show InChI InChI=1S/C24H28N4O4/c1-30-19-14-21(31-2)23(22(15-19)32-3)20-16-25-28(26-20)24(29)27-12-8-7-11-18(27)13-17-9-5-4-6-10-17/h4-6,9-10,14-16,18H,7-8,11-13H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434936
PNG
(N-neopentyl-N-(2-(pyridin-4- yl)ethyl)-4-(4- (trif...)
Show SMILES CC(C)(C)CN(CCc1ccncc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2,3)15-29(13-10-16-8-11-26-12-9-16)20(31)30-27-14-19(28-30)17-4-6-18(7-5-17)32-22(23,24)25/h4-9,11-12,14H,10,13,15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434901
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-33(2)29(36)26-17-13-24(14-18-26)23-11-15-25(16-12-23)28-21-35(32-31-28)30(37)34-19-7-6-10-27(34)20-22-8-4-3-5-9-22/h3-5,8-9,11-18,21,27H,6-7,10,19-20H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434887
PNG
((2-benzylpiperidin-1-yl)(4-(2',4'- dimethoxy-[1,1'...)
Show SMILES COc1ccc(c(OC)c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C29H30N4O3/c1-35-25-15-16-26(28(19-25)36-2)22-11-13-23(14-12-22)27-20-33(31-30-27)29(34)32-17-7-6-10-24(32)18-21-8-4-3-5-9-21/h3-5,8-9,11-16,19-20,24H,6-7,10,17-18H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434938
PNG
(N-neopentyl-N-(2-(pyridin-3- yl)ethyl)-4-(4- (trif...)
Show SMILES CC(C)(C)CN(CCc1cccnc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N5O2/c1-21(2,3)15-29(12-10-16-5-4-11-26-13-16)20(31)30-27-14-19(28-30)17-6-8-18(9-7-17)32-22(23,24)25/h4-9,11,13-14H,10,12,15H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434922
PNG
((2-benzylpiperidin-1-yl)(4-(4- ((dimethylamino)met...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C24H29N5O/c1-27(2)17-20-11-13-21(14-12-20)23-18-29(26-25-23)24(30)28-15-7-6-10-22(28)16-19-8-4-3-5-9-19/h3-5,8-9,11-14,18,22H,6-7,10,15-17H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434894
PNG
((4-(2',6'-dimethoxy-4'-methyl- [1,1'-biphenyl]-4-y...)
Show SMILES COc1cc(C)cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccncc1
Show InChI InChI=1S/C29H31N5O3/c1-20-16-26(36-2)28(27(17-20)37-3)23-9-7-22(8-10-23)25-19-34(32-31-25)29(35)33-15-5-4-6-24(33)18-21-11-13-30-14-12-21/h7-14,16-17,19,24H,4-6,15,18H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434890
PNG
((2-benzylpiperidin-1-yl)(4-(2',6'- dimethoxy-4'-me...)
Show SMILES COc1cc(C)cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H32N4O3/c1-21-17-27(36-2)29(28(18-21)37-3)24-14-12-23(13-15-24)26-20-34(32-31-26)30(35)33-16-8-7-11-25(33)19-22-9-5-4-6-10-22/h4-6,9-10,12-15,17-18,20,25H,7-8,11,16,19H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434931
PNG
(N-cyclobutyl-N-phenethyl-4-(4- (trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CCC1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-19-11-9-17(10-12-19)20-15-26-29(27-20)21(30)28(18-7-4-8-18)14-13-16-5-2-1-3-6-16/h1-3,5-6,9-12,15,18H,4,7-8,13-14H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434929
PNG
(N-(2-ethylbutyl)-N-phenethyl-4- (4-(trifluorometho...)
Show SMILES CCC(CC)CN(CCc1ccccc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C24H27F3N4O2/c1-3-18(4-2)17-30(15-14-19-8-6-5-7-9-19)23(32)31-28-16-22(29-31)20-10-12-21(13-11-20)33-24(25,26)27/h5-13,16,18H,3-4,14-15,17H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434884
PNG
((2-benzylpiperidin-1-yl)(4-(4- (pyridin-4-yl)pheny...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C26H25N5O/c32-26(30-17-5-4-8-24(30)18-20-6-2-1-3-7-20)31-19-25(28-29-31)23-11-9-21(10-12-23)22-13-15-27-16-14-22/h1-3,6-7,9-16,19,24H,4-5,8,17-18H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434885
PNG
((2-benzylpiperidin-1-yl)(4-(4- (pyridin-3-yl)pheny...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C26H25N5O/c32-26(30-16-5-4-10-24(30)17-20-7-2-1-3-8-20)31-19-25(28-29-31)22-13-11-21(12-14-22)23-9-6-15-27-18-23/h1-3,6-9,11-15,18-19,24H,4-5,10,16-17H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434896
PNG
((2-benzylpiperidin-1-yl)(4-(4- (3,5-dimethoxypyrid...)
Show SMILES COc1cncc(OC)c1-c1ccc(cc1)-c1cnn(n1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-35-25-18-29-19-26(36-2)27(25)22-13-11-21(12-14-22)24-17-30-33(31-24)28(34)32-15-7-6-10-23(32)16-20-8-4-3-5-9-20/h3-5,8-9,11-14,17-19,23H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434923
PNG
((2-benzylpiperidin-1-yl)(4-(4- (pyrrolidin-1-ylmet...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(CN2CCCC2)cc1
Show InChI InChI=1S/C26H31N5O/c32-26(30-17-5-4-10-24(30)18-21-8-2-1-3-9-21)31-20-25(27-28-31)23-13-11-22(12-14-23)19-29-15-6-7-16-29/h1-3,8-9,11-14,20,24H,4-7,10,15-19H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434883
PNG
(N-(2-Ethylbutyl)-N-(2-(pyridin-4-yl)ethyl)-4-(4-(t...)
Show SMILES CCC(CC)CN(CCc1ccncc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H26F3N5O2/c1-3-17(4-2)16-30(14-11-18-9-12-27-13-10-18)22(32)31-28-15-21(29-31)19-5-7-20(8-6-19)33-23(24,25)26/h5-10,12-13,15,17H,3-4,11,14,16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434921
PNG
(4-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tri...)
Show SMILES CS(=O)(=O)OCc1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C23H26N4O4S/c1-32(29,30)31-17-19-10-12-20(13-11-19)22-16-27(25-24-22)23(28)26-14-6-5-9-21(26)15-18-7-3-2-4-8-18/h2-4,7-8,10-13,16,21H,5-6,9,14-15,17H2,1H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434922
PNG
((2-benzylpiperidin-1-yl)(4-(4- ((dimethylamino)met...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C24H29N5O/c1-27(2)17-20-11-13-21(14-12-20)23-18-29(26-25-23)24(30)28-15-7-6-10-22(28)16-19-8-4-3-5-9-19/h3-5,8-9,11-14,18,22H,6-7,10,15-17H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434896
PNG
((2-benzylpiperidin-1-yl)(4-(4- (3,5-dimethoxypyrid...)
Show SMILES COc1cncc(OC)c1-c1ccc(cc1)-c1cnn(n1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C28H29N5O3/c1-35-25-18-29-19-26(36-2)27(25)22-13-11-21(12-14-22)24-17-30-33(31-24)28(34)32-15-7-6-10-23(32)16-20-8-4-3-5-9-20/h3-5,8-9,11-14,17-19,23H,6-7,10,15-16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434883
PNG
(N-(2-Ethylbutyl)-N-(2-(pyridin-4-yl)ethyl)-4-(4-(t...)
Show SMILES CCC(CC)CN(CCc1ccncc1)C(=O)n1ncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H26F3N5O2/c1-3-17(4-2)16-30(14-11-18-9-12-27-13-10-18)22(32)31-28-15-21(29-31)19-5-7-20(8-6-19)33-23(24,25)26/h5-10,12-13,15,17H,3-4,11,14,16H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434901
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-33(2)29(36)26-17-13-24(14-18-26)23-11-15-25(16-12-23)28-21-35(32-31-28)30(37)34-19-7-6-10-27(34)20-22-8-4-3-5-9-22/h3-5,8-9,11-18,21,27H,6-7,10,19-20H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434911
PNG
((2-benzylpiperidin-1-yl)(4- (2,4,6-trimethoxypheny...)
Show SMILES COc1cc(OC)c(-c2cnn(n2)C(=O)N2CCCCC2Cc2ccccc2)c(OC)c1
Show InChI InChI=1S/C24H28N4O4/c1-30-19-14-21(31-2)23(22(15-19)32-3)20-16-25-28(26-20)24(29)27-12-8-7-11-18(27)13-17-9-5-4-6-10-17/h4-6,9-10,14-16,18H,7-8,11-13H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434906
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES COc1cc(cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1)C(=O)N(C)C
Show InChI InChI=1S/C32H35N5O4/c1-35(2)31(38)25-19-28(40-3)30(29(20-25)41-4)24-15-13-23(14-16-24)27-21-37(34-33-27)32(39)36-17-9-8-12-26(36)18-22-10-6-5-7-11-22/h5-7,10-11,13-16,19-21,26H,8-9,12,17-18H2,1-4H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens (Human))
BDBM434910
PNG
((2-benzylpiperidin-1-yl)(4- (2,4,6-trimethoxypheny...)
Show SMILES COc1cc(OC)c(-c2cn(nn2)C(=O)N2CCCCC2Cc2ccccc2)c(OC)c1
Show InChI InChI=1S/C24H28N4O4/c1-30-19-14-21(31-2)23(22(15-19)32-3)20-16-28(26-25-20)24(29)27-12-8-7-11-18(27)13-17-9-5-4-6-10-17/h4-6,9-10,14-16,18H,7-8,11-13H2,1-3H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434907
PNG
((2-benzylpiperidin-1-yl)(4-(2',6'- dimethoxy-4'-(p...)
Show SMILES COc1cc(cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1)C(=O)N1CCCC1
Show InChI InChI=1S/C34H37N5O4/c1-42-30-21-27(33(40)37-17-8-9-18-37)22-31(43-2)32(30)26-15-13-25(14-16-26)29-23-39(36-35-29)34(41)38-19-7-6-12-28(38)20-24-10-4-3-5-11-24/h3-5,10-11,13-16,21-23,28H,6-9,12,17-20H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434923
PNG
((2-benzylpiperidin-1-yl)(4-(4- (pyrrolidin-1-ylmet...)
Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(CN2CCCC2)cc1
Show InChI InChI=1S/C26H31N5O/c32-26(30-17-5-4-10-24(30)18-21-8-2-1-3-9-21)31-20-25(27-28-31)23-13-11-22(12-14-23)19-29-15-6-7-16-29/h1-3,8-9,11-14,20,24H,4-7,10,15-19H2
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434905
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES CNC(=O)c1cc(OC)c(c(OC)c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C31H33N5O4/c1-32-30(37)24-18-27(39-2)29(28(19-24)40-3)23-14-12-22(13-15-23)26-20-36(34-33-26)31(38)35-16-8-7-11-25(35)17-21-9-5-4-6-10-21/h4-6,9-10,12-15,18-20,25H,7-8,11,16-17H2,1-3H3,(H,32,37)
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434902
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-33(2)29(36)26-12-8-11-25(20-26)23-14-16-24(17-15-23)28-21-35(32-31-28)30(37)34-18-7-6-13-27(34)19-22-9-4-3-5-10-22/h3-5,8-12,14-17,20-21,27H,6-7,13,18-19H2,1-2H3
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase beta


(Homo sapiens (Human))
BDBM434904
PNG
(4'-(1-(2-benzylpiperidine-1- carbonyl)-1H-1,2,3-tr...)
Show SMILES COc1cc(cc(OC)c1-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H31N5O4/c1-38-26-17-23(29(31)36)18-27(39-2)28(26)22-13-11-21(12-14-22)25-19-35(33-32-25)30(37)34-15-7-6-10-24(34)16-20-8-4-3-5-9-20/h3-5,8-9,11-14,17-19,24H,6-7,10,15-16H2,1-2H3,(H2,31,36)
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THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY

US Patent


Assay Description
Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...


US Patent US10583137 (2020)


BindingDB Entry DOI: 10.7270/Q20K2BZX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%