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Patent code US10584103

Compile Data Set for Download or QSAR

Found 224 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297632
PNG
(2-cyclopropyl-4-(4-(2- methoxyphenyl)piperidin-1- ...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2cnc(cc12)N(C)CCN1CCOCC1)C1CC1
Show InChI InChI=1S/C29H38N6O2/c1-33(13-14-34-15-17-37-18-16-34)27-19-24-25(20-30-27)31-28(22-7-8-22)32-29(24)35-11-9-21(10-12-35)23-5-3-4-6-26(23)36-2/h3-6,19-22H,7-18H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297701
PNG
(2-{[8-Fluoro-4-[4-(3-methoxy- pyrazin-2-yl)-piperi...)
Show SMILES COc1nccnc1C1CCN(CC1)c1nc(nc2c(F)cc(cc12)N(C)CCO)C1(C)CC1
Show InChI InChI=1S/C25H31FN6O2/c1-25(6-7-25)24-29-21-18(14-17(15-19(21)26)31(2)12-13-33)22(30-24)32-10-4-16(5-11-32)20-23(34-3)28-9-8-27-20/h8-9,14-16,33H,4-7,10-13H2,1-3H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297709
PNG
(2-{[2-(1-Fluoro-cyclopropyl)-4- (3'-methoxy-3,4,5,...)
Show SMILES COc1cnccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1
Show InChI InChI=1S/C25H30FN5O2/c1-30(13-14-32)18-3-4-21-20(15-18)23(29-24(28-21)25(26)8-9-25)31-11-6-17(7-12-31)19-5-10-27-16-22(19)33-2/h3-5,10,15-17,32H,6-9,11-14H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297710
PNG
(2-({8-Fluoro-2-(1-fluoro- cyclopropyl)-4-[4-(3-met...)
Show SMILES COc1nccnc1C1CCN(CC1)c1nc(nc2c(F)cc(cc12)N(C)CCO)C1(F)CC1
Show InChI InChI=1S/C24H28F2N6O2/c1-31(11-12-33)16-13-17-20(18(25)14-16)29-23(24(26)5-6-24)30-21(17)32-9-3-15(4-10-32)19-22(34-2)28-8-7-27-19/h7-8,13-15,33H,3-6,9-12H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297719
PNG
(US10118902, Example 223 | US10584103, Example 223 ...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCOCCF)C1(F)CC1
Show InChI InChI=1S/C28H34F2N4O2/c1-33(16-18-36-17-13-29)21-7-8-24-23(19-21)26(32-27(31-24)28(30)11-12-28)34-14-9-20(10-15-34)22-5-3-4-6-25(22)35-2/h3-8,19-20H,9-18H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297501
PNG
(4-[4-(2-azetidin-1-yl-phenyl)- piperidin-1-yl]-2-c...)
Show SMILES CN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1CC1
Show InChI InChI=1S/C27H33N5/c1-30(2)21-10-11-24-23(18-21)27(29-26(28-24)20-8-9-20)32-16-12-19(13-17-32)22-6-3-4-7-25(22)31-14-5-15-31/h3-4,6-7,10-11,18-20H,5,8-9,12-17H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297532
PNG
(4-(4-(2-methoxyphenyl)piperidin- 1-yl)-N-methyl-2-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(C)CC1
Show InChI InChI=1S/C31H41N5O2/c1-31(12-13-31)30-32-27-9-8-24(34(2)16-17-35-18-20-38-21-19-35)22-26(27)29(33-30)36-14-10-23(11-15-36)25-6-4-5-7-28(25)37-3/h4-9,22-23H,10-21H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297550
PNG
(4-[4-(2-methoxy-phenyl)- piperidin-1-yl]-2-(1-meth...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(C)CCCC1
Show InChI InChI=1S/C33H45N5O2/c1-33(14-6-7-15-33)32-34-29-11-10-26(36(2)18-19-37-20-22-40-23-21-37)24-28(29)31(35-32)38-16-12-25(13-17-38)27-8-4-5-9-30(27)39-3/h4-5,8-11,24-25H,6-7,12-23H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297555
PNG
(2-{[4-[4-(2-dimethylamino- phenyl)-piperidin-1-yl]...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(CCCC1)C(F)(F)F
Show InChI InChI=1S/C30H38F3N5O/c1-36(2)26-9-5-4-8-23(26)21-12-16-38(17-13-21)27-24-20-22(37(3)18-19-39)10-11-25(24)34-28(35-27)29(30(31,32)33)14-6-7-15-29/h4-5,8-11,20-21,39H,6-7,12-19H2,1-3H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297572
PNG
(US10118902, Example 74 | US10584103, Example 74 | ...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1CCCC1
Show InChI InChI=1S/C33H46N6O/c1-36(2)31-11-7-6-10-28(31)25-14-16-39(17-15-25)33-29-24-27(37(3)18-19-38-20-22-40-23-21-38)12-13-30(29)34-32(35-33)26-8-4-5-9-26/h6-7,10-13,24-26H,4-5,8-9,14-23H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297573
PNG
(2-{[4-[4-(2-dimethylamino- phenyl)-piperidin-1-yl]...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CCCC1
Show InChI InChI=1S/C29H38FN5O/c1-33(2)26-9-5-4-8-23(26)21-12-16-35(17-13-21)27-24-20-22(34(3)18-19-36)10-11-25(24)31-28(32-27)29(30)14-6-7-15-29/h4-5,8-11,20-21,36H,6-7,12-19H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297576
PNG
((1-{2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N1CCC(CC1)N(C)C)C1CC1
Show InChI InChI=1S/C30H39N5O/c1-33(2)23-14-18-34(19-15-23)24-10-11-27-26(20-24)30(32-29(31-27)22-8-9-22)35-16-12-21(13-17-35)25-6-4-5-7-28(25)36-3/h4-7,10-11,20-23H,8-9,12-19H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297587
PNG
(2-({2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(CN(C)CCO)cc12)C1CC1
Show InChI InChI=1S/C27H34N4O2/c1-30(15-16-32)18-19-7-10-24-23(17-19)27(29-26(28-24)21-8-9-21)31-13-11-20(12-14-31)22-5-3-4-6-25(22)33-2/h3-7,10,17,20-21,32H,8-9,11-16,18H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297601
PNG
(2-({5-chloro-2-cyclopropyl-4-[4- (2-methoxy-phenyl...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(N(C)CCO)c(Cl)c12)C1CC1
Show InChI InChI=1S/C26H31ClN4O2/c1-30(15-16-32)21-10-9-20-23(24(21)27)26(29-25(28-20)18-7-8-18)31-13-11-17(12-14-31)19-5-3-4-6-22(19)33-2/h3-6,9-10,17-18,32H,7-8,11-16H2,1-2H3
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297602
PNG
(US10118902, Example 104 | US10584103, Example 104 ...)
Show SMILES CCCN(C)c1cc2c(nc(nc2cc1Cl)C1CC1)N1CCC(CC1)c1ccccc1OC
Show InChI InChI=1S/C27H33ClN4O/c1-4-13-31(2)24-16-21-23(17-22(24)28)29-26(19-9-10-19)30-27(21)32-14-11-18(12-15-32)20-7-5-6-8-25(20)33-3/h5-8,16-19H,4,9-15H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297616
PNG
(2-({7-chloro-2-cyclopropyl-4-[4- (2-dimethylamino-...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2cc(Cl)c(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C27H34ClN5O/c1-31(2)24-7-5-4-6-20(24)18-10-12-33(13-11-18)27-21-16-25(32(3)14-15-34)22(28)17-23(21)29-26(30-27)19-8-9-19/h4-7,16-19,34H,8-15H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297623
PNG
(2-({2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2c(C)cc(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C27H34N4O2/c1-18-16-21(30(2)14-15-32)17-23-25(18)28-26(20-8-9-20)29-27(23)31-12-10-19(11-13-31)22-6-4-5-7-24(22)33-3/h4-7,16-17,19-20,32H,8-15H2,1-3H3
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297643
PNG
((2-methoxy-ethyl)-{4-[4-(2- methoxy-phenyl)-piperi...)
Show SMILES COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)-c1ccccc1
Show InChI InChI=1S/C30H34N4O2/c1-33(19-20-35-2)24-13-14-27-26(21-24)30(32-29(31-27)23-9-5-4-6-10-23)34-17-15-22(16-18-34)25-11-7-8-12-28(25)36-3/h4-14,21-22H,15-20H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297649
PNG
(2-[(2-cyclopropyl-4-{2-[(2- methoxy-phenyl)-methyl...)
Show SMILES COc1ccccc1N(C)C1CCCC1Nc1nc(nc2ccc(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C27H35N5O2/c1-31(15-16-33)19-13-14-21-20(17-19)27(30-26(28-21)18-11-12-18)29-22-7-6-9-23(22)32(2)24-8-4-5-10-25(24)34-3/h4-5,8,10,13-14,17-18,22-23,33H,6-7,9,11-12,15-16H2,1-3H3,(H,28,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297658
PNG
(2-{2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperidi...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc(C)c1CC(=O)Nc1ccccc1)C1CC1
Show InChI InChI=1S/C28H32N4O2/c1-19-24(18-26(33)30-22-8-4-3-5-9-22)28(31-27(29-19)21-12-13-21)32-16-14-20(15-17-32)23-10-6-7-11-25(23)34-2/h3-11,20-21H,12-18H2,1-2H3,(H,30,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297630
PNG
(2-((2-cyclopropyl-5-fluoro-4-(4- (2-methoxyphenyl)...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(N(C)CCO)c(F)c12)C1CC1
Show InChI InChI=1S/C26H31FN4O2/c1-30(15-16-32)21-10-9-20-23(24(21)27)26(29-25(28-20)18-7-8-18)31-13-11-17(12-14-31)19-5-3-4-6-22(19)33-2/h3-6,9-10,17-18,32H,7-8,11-16H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297675
PNG
((S)-1-{2-(1-Fluoro-cyclopropyl)- 4-[4-(2-methoxy-p...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N1CC[C@H](O)C1)C1(F)CC1
Show InChI InChI=1S/C27H31FN4O2/c1-34-24-5-3-2-4-21(24)18-8-13-31(14-9-18)25-22-16-19(32-15-10-20(33)17-32)6-7-23(22)29-26(30-25)27(28)11-12-27/h2-7,16,18,20,33H,8-15,17H2,1H3/t20-/m0/s1
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297676
PNG
((R)-1-{2-(1-Fluoro-cyclopropyl)-4- [4-(2-methoxy-p...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N1CC[C@@H](O)C1)C1(F)CC1
Show InChI InChI=1S/C27H31FN4O2/c1-34-24-5-3-2-4-21(24)18-8-13-31(14-9-18)25-22-16-19(32-15-10-20(33)17-32)6-7-23(22)29-26(30-25)27(28)11-12-27/h2-7,16,18,20,33H,8-15,17H2,1H3/t20-/m1/s1
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297652
PNG
(2-((2-cyclopropyl-4-((1-(2- methoxyphenyl)pyrrolid...)
Show SMILES COc1ccccc1N1CCC(C1)Nc1nc(nc2ccc(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C25H31N5O2/c1-29(13-14-31)19-9-10-21-20(15-19)25(28-24(27-21)17-7-8-17)26-18-11-12-30(16-18)22-5-3-4-6-23(22)32-2/h3-6,9-10,15,17-18,31H,7-8,11-14,16H2,1-2H3,(H,26,27,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297697
PNG
(1-{2-(1-Fluoro-cyclobutyl)-4-[4- (2-methoxy-phenyl...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2cnc(cc12)N1CC[C@H](O)C1)C1(F)CCC1
Show InChI InChI=1S/C27H32FN5O2/c1-35-23-6-3-2-5-20(23)18-7-12-32(13-8-18)25-21-15-24(33-14-9-19(34)17-33)29-16-22(21)30-26(31-25)27(28)10-4-11-27/h2-3,5-6,15-16,18-19,34H,4,7-14,17H2,1H3/t19-/m0/s1
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297715
PNG
(2-({2-(1-Fluoro-cyclopropyl)-4- [4-(4-iodo-2-metho...)
Show SMILES COc1cc(I)ccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1
Show InChI InChI=1S/C26H30FIN4O2/c1-31(13-14-33)19-4-6-22-21(16-19)24(30-25(29-22)26(27)9-10-26)32-11-7-17(8-12-32)20-5-3-18(28)15-23(20)34-2/h3-6,15-17,33H,7-14H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM435186
PNG
(1-(6-((2- hydroxyethyl)(methyl)amino)-4-(4- (3-met...)
Show SMILES COc1nccnc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(O)CCC1
Show InChI InChI=1S/C25H32N6O3/c1-30(14-15-32)18-4-5-20-19(16-18)22(29-24(28-20)25(33)8-3-9-25)31-12-6-17(7-13-31)21-23(34-2)27-11-10-26-21/h4-5,10-11,16-17,32-33H,3,6-9,12-15H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297506
PNG
(US10118902, Example 8 | US10584103, Example 8 | {4...)
Show SMILES CN(CCN1CCOCC1)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1CC1
Show InChI InChI=1S/C32H42N6O/c1-35(17-18-36-19-21-39-22-20-36)26-9-10-29-28(23-26)32(34-31(33-29)25-7-8-25)38-15-11-24(12-16-38)27-5-2-3-6-30(27)37-13-4-14-37/h2-3,5-6,9-10,23-25H,4,7-8,11-22H2,1H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297517
PNG
(US10118902, Example 19 | US10584103, Example 19 | ...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)C)C1(CC1)N(C)C
Show InChI InChI=1S/C27H35N5O/c1-30(2)20-10-11-23-22(18-20)25(29-26(28-23)27(14-15-27)31(3)4)32-16-12-19(13-17-32)21-8-6-7-9-24(21)33-5/h6-11,18-19H,12-17H2,1-5H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297542
PNG
(2-cyclobutyl-4-[4-(2-methoxy- phenyl)-piperidin-1-...)
Show SMILES COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CCC1
Show InChI InChI=1S/C28H36N4O2/c1-31(17-18-33-2)22-11-12-25-24(19-22)28(30-27(29-25)21-7-6-8-21)32-15-13-20(14-16-32)23-9-4-5-10-26(23)34-3/h4-5,9-12,19-21H,6-8,13-18H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297543
PNG
(US10118902, Example 45 | US10584103, Example 45 | ...)
Show SMILES CCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CCC1
Show InChI InChI=1S/C28H36N4O/c1-4-16-31(2)22-12-13-25-24(19-22)28(30-27(29-25)21-8-7-9-21)32-17-14-20(15-18-32)23-10-5-6-11-26(23)33-3/h5-6,10-13,19-21H,4,7-9,14-18H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297560
PNG
(US10118902, Example 62 | US10584103, Example 62 | ...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(F)CCC1
Show InChI InChI=1S/C32H43FN6O/c1-36(2)29-8-5-4-7-26(29)24-11-15-39(16-12-24)30-27-23-25(37(3)17-18-38-19-21-40-22-20-38)9-10-28(27)34-31(35-30)32(33)13-6-14-32/h4-5,7-10,23-24H,6,11-22H2,1-3H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297570
PNG
(2-({2-(1-fluoro-cyclopentyl)-4-[4- (2-methoxy-phen...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CCCC1
Show InChI InChI=1S/C28H35FN4O2/c1-32(17-18-34)21-9-10-24-23(19-21)26(31-27(30-24)28(29)13-5-6-14-28)33-15-11-20(12-16-33)22-7-3-4-8-25(22)35-2/h3-4,7-10,19-20,34H,5-6,11-18H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297577
PNG
(1-{2-cyclopropyl-4-[4-(2-methoxy- phenyl)-piperidi...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N1CCC(O)C1)C1CC1
Show InChI InChI=1S/C27H32N4O2/c1-33-25-5-3-2-4-22(25)18-10-13-30(14-11-18)27-23-16-20(31-15-12-21(32)17-31)8-9-24(23)28-26(29-27)19-6-7-19/h2-5,8-9,16,18-19,21,32H,6-7,10-15,17H2,1H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297578
PNG
(2-cyclopropyl-4-[4-(2-methoxy- phenyl)-piperidin-1...)
Show SMILES COC1CCN(C1)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C28H34N4O2/c1-33-22-13-16-32(18-22)21-9-10-25-24(17-21)28(30-27(29-25)20-7-8-20)31-14-11-19(12-15-31)23-5-3-4-6-26(23)34-2/h3-6,9-10,17,19-20,22H,7-8,11-16,18H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297581
PNG
((R)-2-cyclopropyl-4-(4-(2- methoxyphenyl)piperidin...)
Show SMILES CO[C@@H]1CCN(C1)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C28H34N4O2/c1-33-22-13-16-32(18-22)21-9-10-25-24(17-21)28(30-27(29-25)20-7-8-20)31-14-11-19(12-15-31)23-5-3-4-6-26(23)34-2/h3-6,9-10,17,19-20,22H,7-8,11-16,18H2,1-2H3/t22-/m1/s1
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297583
PNG
(US10118902, Example 85 | US10584103, Example 85 | ...)
Show SMILES CCCN(C)Cc1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C28H36N4O/c1-4-15-31(2)19-20-9-12-25-24(18-20)28(30-27(29-25)22-10-11-22)32-16-13-21(14-17-32)23-7-5-6-8-26(23)33-3/h5-9,12,18,21-22H,4,10-11,13-17,19H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297584
PNG
(US10118902, Example 86 | US10584103, Example 86 | ...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(CN(C)C)cc12)C1CC1
Show InChI InChI=1S/C26H32N4O/c1-29(2)17-18-8-11-23-22(16-18)26(28-25(27-23)20-9-10-20)30-14-12-19(13-15-30)21-6-4-5-7-24(21)31-3/h4-8,11,16,19-20H,9-10,12-15,17H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297585
PNG
(US10118902, Example 87 | US10584103, Example 87 | ...)
Show SMILES COCCN(C)Cc1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C28H36N4O2/c1-31(16-17-33-2)19-20-8-11-25-24(18-20)28(30-27(29-25)22-9-10-22)32-14-12-21(13-15-32)23-6-4-5-7-26(23)34-3/h4-8,11,18,21-22H,9-10,12-17,19H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297588
PNG
(({2-cyclopropyl-4-[4-(2-methoxy- phenyl)-piperidin...)
Show SMILES CCOC(=O)CN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C28H34N4O3/c1-4-35-26(33)18-31(2)21-11-12-24-23(17-21)28(30-27(29-24)20-9-10-20)32-15-13-19(14-16-32)22-7-5-6-8-25(22)34-3/h5-8,11-12,17,19-20H,4,9-10,13-16,18H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297591
PNG
(US10118902, Example 93 | US10584103, Example 93 | ...)
Show SMILES CCOC(=O)CN(C)C1CCN(CC1)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C33H43N5O3/c1-4-41-31(39)22-36(2)25-15-19-37(20-16-25)26-11-12-29-28(21-26)33(35-32(34-29)24-9-10-24)38-17-13-23(14-18-38)27-7-5-6-8-30(27)40-3/h5-8,11-12,21,23-25H,4,9-10,13-20,22H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297593
PNG
(4-(4-(2-methoxyphenyl)piperidin- 1-yl)-N2,N2,N6-tr...)
Show SMILES CCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)N(C)C
Show InChI InChI=1S/C26H35N5O/c1-6-15-30(4)20-11-12-23-22(18-20)25(28-26(27-23)29(2)3)31-16-13-19(14-17-31)21-9-7-8-10-24(21)32-5/h7-12,18-19H,6,13-17H2,1-5H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297604
PNG
(US10118902, Example 106 | US10584103, Example 106 ...)
Show SMILES CCCN(C)c1cc2c(nc(nc2cc1F)C1CC1)N1CCC(CC1)c1ccccc1N1CCC1
Show InChI InChI=1S/C29H36FN5/c1-3-13-33(2)27-18-23-25(19-24(27)30)31-28(21-9-10-21)32-29(23)35-16-11-20(12-17-35)22-7-4-5-8-26(22)34-14-6-15-34/h4-5,7-8,18-21H,3,6,9-17H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297609
PNG
(2-({2-cyclopropyl-7-fluoro-4-[4- (5-fluoro-2-metho...)
Show SMILES COc1ccc(F)cc1C1CCN(CC1)c1nc(nc2cc(F)c(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C26H30F2N4O2/c1-31(11-12-33)23-14-20-22(15-21(23)28)29-25(17-3-4-17)30-26(20)32-9-7-16(8-10-32)19-13-18(27)5-6-24(19)34-2/h5-6,13-17,33H,3-4,7-12H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297614
PNG
(2-({2-cyclopropyl-4-[4-(2- dimethylamino-phenyl)-p...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2cc(C)c(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C28H37N5O/c1-19-17-24-23(18-26(19)32(4)15-16-34)28(30-27(29-24)21-9-10-21)33-13-11-20(12-14-33)22-7-5-6-8-25(22)31(2)3/h5-8,17-18,20-21,34H,9-16H2,1-4H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297620
PNG
(US10118902, Example 122 | US10584103, Example 122 ...)
Show SMILES CCCN(C)c1cc2c(nc(nc2cc1C)C1CC1)N1CCC(CC1)c1ccccc1OC
Show InChI InChI=1S/C28H36N4O/c1-5-14-31(3)25-18-23-24(17-19(25)2)29-27(21-10-11-21)30-28(23)32-15-12-20(13-16-32)22-8-6-7-9-26(22)33-4/h6-9,17-18,20-21H,5,10-16H2,1-4H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297621
PNG
(US10118902, Example 123 | US10584103, Example 123 ...)
Show SMILES CCCN(C)c1cc2c(nc(nc2cc1C)C1CC1)N1CCC(CC1)c1cc(F)ccc1OC
Show InChI InChI=1S/C28H35FN4O/c1-5-12-32(3)25-17-23-24(15-18(25)2)30-27(20-6-7-20)31-28(23)33-13-10-19(11-14-33)22-16-21(29)8-9-26(22)34-4/h8-9,15-17,19-20H,5-7,10-14H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297622
PNG
(2-({2-cyclopropyl-7-fluoro-4-[4- (2-methoxy-phenyl...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2cc(F)c(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C26H31FN4O2/c1-30(13-14-32)23-15-20-22(16-21(23)27)28-25(18-7-8-18)29-26(20)31-11-9-17(10-12-31)19-5-3-4-6-24(19)33-2/h3-6,15-18,32H,7-14H2,1-2H3
PDB

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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297626
PNG
(US10118902, Example 128 | US10584103, Example 128 ...)
Show SMILES CCCN(C)c1cccc2c(nc(nc12)C1CC1)N1CCC(CC1)c1ccccc1OC
Show InChI InChI=1S/C27H34N4O/c1-4-16-30(2)23-10-7-9-22-25(23)28-26(20-12-13-20)29-27(22)31-17-14-19(15-18-31)21-8-5-6-11-24(21)32-3/h5-11,19-20H,4,12-18H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))		BDBM297637
PNG
(2-((4-(4-cyclohexylpiperidin- 1-yl)-2-(1-fluorocyc...)
Show SMILES CN(CCO)c1ccc2nc(nc(N3CCC(CC3)C3CCCCC3)c2c1)C1(F)CC1
Show InChI InChI=1S/C25H35FN4O/c1-29(15-16-31)20-7-8-22-21(17-20)23(28-24(27-22)25(26)11-12-25)30-13-9-19(10-14-30)18-5-3-2-4-6-18/h7-8,17-19,31H,2-6,9-16H2,1H3
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...

US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%