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Patent code US10584104

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434982
PNG
(US10584104, Compound of Example 51)
Show SMILES OC(=O)CSc1nnc(Br)n1Cc1ccc(Br)c2ccccc12
Show InChI InChI=1S/C15H11Br2N3O2S/c16-12-6-5-9(10-3-1-2-4-11(10)12)7-20-14(17)18-19-15(20)23-8-13(21)22/h1-6H,7-8H2,(H,21,22)
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n/an/a 81n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434983
PNG
(US10584104, Compound of Example 52)
Show SMILES OC(=O)CCc1nnc(Br)n1Cc1ccc(Br)c2ccccc12
Show InChI InChI=1S/C16H13Br2N3O2/c17-13-6-5-10(11-3-1-2-4-12(11)13)9-21-14(7-8-15(22)23)19-20-16(21)18/h1-6H,7-9H2,(H,22,23)
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n/an/a 83n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434973
PNG
(US10584104, Compound of Example 10)
Show SMILES CCCc1ccc(Cn2c(Br)nnc2SCC(O)=O)c2ccccc12
Show InChI InChI=1S/C18H18BrN3O2S/c1-2-5-12-8-9-13(15-7-4-3-6-14(12)15)10-22-17(19)20-21-18(22)25-11-16(23)24/h3-4,6-9H,2,5,10-11H2,1H3,(H,23,24)
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n/an/a 94n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434978
PNG
(US10584104, Compound of Example 38)
Show SMILES CCCc1ccc(Cn2c(Br)nnc2CCC(O)=O)c2ccccc12
Show InChI InChI=1S/C19H20BrN3O2/c1-2-5-13-8-9-14(16-7-4-3-6-15(13)16)12-23-17(10-11-18(24)25)21-22-19(23)20/h3-4,6-9H,2,5,10-12H2,1H3,(H,24,25)
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n/an/a 107n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434970
PNG
(US10584104, Compound of Example 2)
Show SMILES [O-]C(=O)CCc1nnc(Br)n1Cc1ccc(C2CC2)c2ccccc12
Show InChI InChI=1S/C19H18BrN3O2/c20-19-22-21-17(9-10-18(24)25)23(19)11-13-7-8-15(12-5-6-12)16-4-2-1-3-14(13)16/h1-4,7-8,12H,5-6,9-11H2,(H,24,25)/p-1
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n/an/a 193n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434969
PNG
(US10584104, Compound of Example 1)
Show SMILES [O-]C(=O)CSc1nnc(Br)n1Cc1ccc(C2CC2)c2ccccc12
Show InChI InChI=1S/C18H16BrN3O2S/c19-17-20-21-18(25-10-16(23)24)22(17)9-12-7-8-14(11-5-6-11)15-4-2-1-3-13(12)15/h1-4,7-8,11H,5-6,9-10H2,(H,23,24)/p-1
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n/an/a 201n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434979
PNG
(US10584104, Compound of Example 39)
Show SMILES CC(C)c1ccc(Cn2c(Br)nnc2CCC(O)=O)c2ccccc12
Show InChI InChI=1S/C19H20BrN3O2/c1-12(2)14-8-7-13(15-5-3-4-6-16(14)15)11-23-17(9-10-18(24)25)21-22-19(23)20/h3-8,12H,9-11H2,1-2H3,(H,24,25)
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n/an/a 381n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434971
PNG
(US10584104, Compound of Example 5)
Show SMILES OC(=O)CSc1nnc(Cl)n1Cc1ccc(C2CC2)c2ccccc12
Show InChI InChI=1S/C18H16ClN3O2S/c19-17-20-21-18(25-10-16(23)24)22(17)9-12-7-8-14(11-5-6-11)15-4-2-1-3-13(12)15/h1-4,7-8,11H,5-6,9-10H2,(H,23,24)
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n/an/a 418n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434972
PNG
(US10584104, Compound of Example 6)
Show SMILES OC(=O)CSc1nnc(I)n1Cc1ccc(C2CC2)c2ccccc12
Show InChI InChI=1S/C18H16IN3O2S/c19-17-20-21-18(25-10-16(23)24)22(17)9-12-7-8-14(11-5-6-11)15-4-2-1-3-13(12)15/h1-4,7-8,11H,5-6,9-10H2,(H,23,24)
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n/an/a 440n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434974
PNG
(US10584104, Compound of Example 11)
Show SMILES CC(C)c1ccc(Cn2c(Br)nnc2SCC(O)=O)c2ccccc12
Show InChI InChI=1S/C18H18BrN3O2S/c1-11(2)13-8-7-12(14-5-3-4-6-15(13)14)9-22-17(19)20-21-18(22)25-10-16(23)24/h3-8,11H,9-10H2,1-2H3,(H,23,24)
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n/an/a 484n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434981
PNG
(US10584104, Compound of Example 49)
Show SMILES CC(C)c1ccc(Cn2c(Br)nnc2CC(C)(C)C(O)=O)c2ccccc12
Show InChI InChI=1S/C21H24BrN3O2/c1-13(2)15-10-9-14(16-7-5-6-8-17(15)16)12-25-18(23-24-20(25)22)11-21(3,4)19(26)27/h5-10,13H,11-12H2,1-4H3,(H,26,27)
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n/an/a 487n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434980
PNG
(US10584104, Compound of Example 48)
Show SMILES CCCc1ccc(Cn2c(Br)nnc2CC(C)(C)C(O)=O)c2ccccc12
Show InChI InChI=1S/C21H24BrN3O2/c1-4-7-14-10-11-15(17-9-6-5-8-16(14)17)13-25-18(23-24-20(25)22)12-21(2,3)19(26)27/h5-6,8-11H,4,7,12-13H2,1-3H3,(H,26,27)
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n/an/a 512n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434976
PNG
(US10584104, Compound of Example 20)
Show SMILES CC(C)(Sc1nnc(Cl)n1Cc1ccc(C2CC2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C20H20ClN3O2S/c1-20(2,17(25)26)27-19-23-22-18(21)24(19)11-13-9-10-15(12-7-8-12)16-6-4-3-5-14(13)16/h3-6,9-10,12H,7-8,11H2,1-2H3,(H,25,26)
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n/an/a 886n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434977
PNG
(US10584104, Compound of Example 25)
Show SMILES CCCc1ccc(Cn2c(Br)nnc2SC(C)(C)C(O)=O)c2ccccc12
Show InChI InChI=1S/C20H22BrN3O2S/c1-4-7-13-10-11-14(16-9-6-5-8-15(13)16)12-24-18(21)22-23-19(24)27-20(2,3)17(25)26/h5-6,8-11H,4,7,12H2,1-3H3,(H,25,26)
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n/an/a 1.01E+3n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434975
PNG
(US10584104, Compound of Example 17)
Show SMILES CC(C)(Sc1nnc(Br)n1Cc1ccc(C2CC2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C20H20BrN3O2S/c1-20(2,17(25)26)27-19-23-22-18(21)24(19)11-13-9-10-15(12-7-8-12)16-6-4-3-5-14(13)16/h3-6,9-10,12H,7-8,11H2,1-2H3,(H,25,26)
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n/an/a 1.02E+3n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434968
PNG
(US10584104, Compound B)
Show SMILES [O-]C(=O)CCc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12
Show InChI InChI=1S/C18H16BrN3O2/c19-18-21-20-16(9-10-17(23)24)22(18)15-8-7-12(11-5-6-11)13-3-1-2-4-14(13)15/h1-4,7-8,11H,5-6,9-10H2,(H,23,24)/p-1
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n/an/a 1.81E+3n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434966
PNG
(US10584104, Compound A)
Show SMILES CC(C)(Sc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12)C([O-])=O
Show InChI InChI=1S/C19H18BrN3O2S/c1-19(2,16(24)25)26-18-22-21-17(20)23(18)15-10-9-12(11-7-8-11)13-5-3-4-6-14(13)15/h3-6,9-11H,7-8H2,1-2H3,(H,24,25)/p-1
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n/an/a 2.13E+3n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM434965
PNG
(US10584104, Compound lesinurad)
Show SMILES [O-]C(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12
Show InChI InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)/p-1
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n/an/a 7.18E+3n/an/an/an/an/an/a



TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

US Patent


Assay Description
After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...


US Patent US10584104 (2020)


BindingDB Entry DOI: 10.7270/Q2GH9MCX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%