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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM21 (6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In order to assess the activity of chemical compounds against the relevant kinase of interest, the Caliper LifeSciences electrophoretic mobility shif... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank US Patent | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In order to assess the activity of chemical compounds against the relevant kinase of interest, the Caliper LifeSciences electrophoretic mobility shif... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In order to assess the activity of chemical compounds against the relevant kinase of interest, the Caliper LifeSciences electrophoretic mobility shif... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50363397 (CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | DrugBank US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In order to assess the activity of chemical compounds against the relevant kinase of interest, the Caliper LifeSciences electrophoretic mobility shif... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) | PDB GoogleScholar | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In order to assess the activity of chemical compounds against the relevant kinase of interest, the Caliper LifeSciences electrophoretic mobility shif... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM50363397 (CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In order to assess the activity of chemical compounds against the relevant kinase of interest, the Caliper LifeSciences electrophoretic mobility shif... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 95.2 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In order to assess the activity of chemical compounds against the relevant kinase of interest, the Caliper LifeSciences electrophoretic mobility shif... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434989 (US10584114, Compound 101) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435001 (US10584114, Compound 114) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435011 (US10584114, Compound 131) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435013 (US10584114, Compound 136) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435013 (US10584114, Compound 136) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434998 (US10584114, Compound 111) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435021 (US10584114, Compound 148) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435023 (US10584114, Compound 150) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435000 (US10584114, Compound 113) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435001 (US10584114, Compound 114) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435004 (US10584114, Compound 120) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435005 (US10584114, Compound 121) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435010 (US10584114, Compound 130) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435017 (US10584114, Compound 142) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435019 (US10584114, Compound 146) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434991 (US10584114, Compound 103) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434991 (US10584114, Compound 103) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435000 (US10584114, Compound 113) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435015 (US10584114, Compound 138) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435018 (US10584114, Compound 144) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435024 (US10584114, Compound 151) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434999 (US10584114, Compound 112) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435005 (US10584114, Compound 121) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435008 (US10584114, Compound 128) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435018 (US10584114, Compound 144) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435024 (US10584114, Compound 151) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434996 (US10584114, Compound 109) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435010 (US10584114, Compound 130) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435021 (US10584114, Compound 148) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435023 (US10584114, Compound 150) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434989 (US10584114, Compound 101) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434995 (US10584114, Compound 107) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434995 (US10584114, Compound 107) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434996 (US10584114, Compound 109) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434999 (US10584114, Compound 112) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435004 (US10584114, Compound 120) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435011 (US10584114, Compound 131) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435017 (US10584114, Compound 142) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434994 (US10584114, Compound 106) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435008 (US10584114, Compound 128) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435015 (US10584114, Compound 138) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435019 (US10584114, Compound 146) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434997 (US10584114, Compound 110) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435016 (US10584114, Compound 141) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435020 (US10584114, Compound 147) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435002 (US10584114, Compound 116) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435012 (US10584114, Compound 135) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434998 (US10584114, Compound 111) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435022 (US10584114, Compound 149) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434993 (US10584114, Compound 105) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435016 (US10584114, Compound 141) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434993 (US10584114, Compound 105) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435020 (US10584114, Compound 147) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434997 (US10584114, Compound 110) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435006 (US10584114, Compound 122) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435006 (US10584114, Compound 122) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435022 (US10584114, Compound 149) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435012 (US10584114, Compound 135) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435007 (US10584114, Compound 124) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434994 (US10584114, Compound 106) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM21 (6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In order to assess the activity of chemical compounds against the relevant kinase of interest, the Caliper LifeSciences electrophoretic mobility shif... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434990 (US10584114, Compound 102) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435014 (US10584114, Compound 137) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435009 (US10584114, Compound 129) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435003 (US10584114, Compound 119) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435007 (US10584114, Compound 124) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435014 (US10584114, Compound 137) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434988 (US10584114, Compound 100) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434992 (US10584114, Compound 104) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM434988 (US10584114, Compound 100) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM435002 (US10584114, Compound 116) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435003 (US10584114, Compound 119) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434992 (US10584114, Compound 104) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM434990 (US10584114, Compound 102) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM435009 (US10584114, Compound 129) | PDB GoogleScholar | UniChem | US Patent | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES... | US Patent US10584114 (2020) BindingDB Entry DOI: 10.7270/Q27083V8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
