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Patent code US10584120

Compile Data Set for Download or QSAR
Found 58 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435105
PNG
(US10584120, Compound 39)
Show SMILES O=C1NC(=O)N(C1c1ccc(cc1)-c1cnc(s1)C1CC1)c1ccc2[nH]cnc2c1
PDB
MMDB

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4n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435104
PNG
(US10584120, Compound 38)
Show SMILES O=C1NC(=O)N(C1c1ccc(cc1)-c1csc(n1)C1CC1)c1ccc2[nH]cnc2c1
PDB
MMDB

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4n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435111
PNG
(US10584120, Compound 45)
Show SMILES O=C1NC(=O)N(C1c1ccc(cc1)-c1nnn(CC2CC2)n1)c1ccc2[nH]cnc2c1
PDB
MMDB

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4n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435108
PNG
(US10584120, Compound 42)
Show SMILES CCCn1nnc(n1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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5n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435128
PNG
(US10584120, Compound 62)
Show SMILES COCc1cc(cs1)-c1ccc(C2CNC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
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6n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435114
PNG
(US10584120, Compound 47)
Show SMILES O=C1NC(=O)N(C1c1ccc(cc1)-c1nnn(CC#C)n1)c1ccc2[nH]cnc2c1
PDB
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6n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435123
PNG
(US10584120, Compound 56)
Show SMILES Fc1c(F)c(ccc1[C@H]1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1csc(c1)C(F)(F)F
PDB
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7n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435126
PNG
(US10584120, Compound 60)
Show SMILES Cc1cc(cs1)-c1ccc(C2CNC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
PDB
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7n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435109
PNG
(US10584120, Compound 43)
Show SMILES CC(C)n1nnc(n1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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8n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435112
PNG
(US10584120, Compound 46)
Show SMILES FC(F)(F)Cn1nnc(n1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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8n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435106
PNG
(US10584120, Compound 40)
Show SMILES FC(F)(F)c1ncc(s1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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9n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435110
PNG
(US10584120, Compound 44)
Show SMILES CC(C)Cn1nnc(n1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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10n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435115
PNG
(US10584120, Compound 48)
Show SMILES CC#CCn1nnc(n1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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10n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435116
PNG
(US10584120, Compound 49)
Show SMILES CCC#CCn1nnc(n1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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10n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435129
PNG
(US10584120, Compound 63)
Show SMILES CCOCc1cc(cs1)-c1ccc(C2CNC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
PDB
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11n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435107
PNG
(US10584120, Compound 41)
Show SMILES Cn1nnc(n1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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12n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435130
PNG
(US10584120, Compound 64)
Show SMILES COC(=O)c1cc(cs1)-c1ccc(C2CNC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
PDB
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13n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435117
PNG
(US10584120, Compound 50)
Show SMILES Clc1ccc(Cn2nnc(n2)-c2ccc(cc2)C2N(C(=O)NC2=O)c2ccc3[nH]cnc3c2)cc1
PDB
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13n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435127
PNG
(US10584120, Compound 61)
Show SMILES CCc1cc(cs1)-c1ccc(C2CNC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
PDB
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16n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435078
PNG
(US10584120, Compound 9)
Show SMILES FC(F)(F)c1ncc(s1)-c1ccc(cc1)[C@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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16n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435103
PNG
(US10584120, Compound 37)
Show SMILES FC(F)(F)c1csc(n1)-c1ccc(cc1)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1
PDB
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18n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435125
PNG
(US10584120, Compound 59)
Show SMILES Fc1c(F)c(ccc1C1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1csc(Cl)c1
PDB
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19n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435131
PNG
(US10584120, Compound 65)
Show SMILES Fc1c(F)c(ccc1C1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1ccsc1
PDB
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20n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435075
PNG
(US10584120, Compound 7)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1cnc(s1)C1CC1
PDB
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21n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435121
PNG
(US10584120, Compound 54)
Show SMILES Fc1cc(ccc1-c1csc(c1)C(F)(F)F)[C@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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23n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435118
PNG
(US10584120, Compound 51)
Show SMILES COc1ccc(Cn2nnc(n2)-c2ccc(cc2)C2N(C(=O)NC2=O)c2ccc3[nH]cnc3c2)cc1
PDB
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24n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435102
PNG
(US10584120, Compound 36)
Show SMILES FC(F)(F)c1cc(cs1)-c1ccc(cc1)[C@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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32n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435090
PNG
(US10584120, Compound 21)
Show SMILES CC(C)n1nnc(n1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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36n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435097
PNG
(US10584120, Compound 28)
Show SMILES Fc1c(F)c(ccc1C1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1csc(c1)C(F)(F)F
PDB
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39n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435076
PNG
(US10584120, Compound 8)
Show SMILES FC(F)(F)c1ncc(s1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
MMDB

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49n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435072
PNG
(US10584120, Compound 1)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1nccs1
PDB
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US Patent
53n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435089
PNG
(US10584120, Compound 20)
Show SMILES CCCn1nnc(n1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
MMDB

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57n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435088
PNG
(US10584120, Compound 19)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1cc(no1)C1CC1
PDB
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58n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435096
PNG
(US10584120, Compound 27)
Show SMILES Fc1cc(cc(F)c1C1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1csc(c1)C(F)(F)F
PDB
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66n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435100
PNG
(US10584120, Compound 34)
Show SMILES FC(F)(F)c1ccc(s1)-c1ccc(cc1)[C@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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69n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435094
PNG
(US10584120, Compound 25)
Show SMILES Fc1cc(ccc1-c1csc(c1)C(F)(F)F)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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71n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435098
PNG
(US10584120, Compound 29)
Show SMILES Clc1ccc(s1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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72n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435084
PNG
(US10584120, Compound 15)
Show SMILES Cc1cc(cs1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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76n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435124
PNG
(US10584120, Compound 57)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1cnc(s1)C12CC3CC(CC(C3)C1)C2
PDB
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87n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435080
PNG
(US10584120, Compound 11)
Show SMILES Cc1ccc(s1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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100n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435073
PNG
(US10584120, Compound 2)
Show SMILES Cc1csc(n1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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100n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435093
PNG
(US10584120, Compound 24)
Show SMILES Fc1cc(cc(F)c1C1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1ccc(s1)C(F)(F)F
PDB
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101n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435083
PNG
(US10584120, Compound 14)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1ccsc1
PDB
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106n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435085
PNG
(US10584120, Compound 16)
Show SMILES FC(F)(F)c1cc(cs1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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112n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435095
PNG
(US10584120, Compound 26)
Show SMILES Fc1cc(ccc1C1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1csc(c1)C(F)(F)F
PDB
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114n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435092
PNG
(US10584120, Compound 23)
Show SMILES Fc1cc(ccc1C1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1ccc(s1)C(F)(F)F
PDB
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124n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435082
PNG
(US10584120, Compound 13)
Show SMILES FC(F)(F)c1ccc(s1)-c1ccc(cc1)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
MMDB

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124n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435081
PNG
(US10584120, Compound 12)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1ccc(s1)C1CC1
PDB
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132n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435087
PNG
(US10584120, Compound 18)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1noc(n1)C1CC1
PDB
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134n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435086
PNG
(US10584120, Compound 17)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1csc(c1)C1CC1
PDB
MMDB

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151n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435091
PNG
(US10584120, Compound 22)
Show SMILES Fc1cc(ccc1-c1ccc(s1)C(F)(F)F)C1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
MMDB

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156n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435074
PNG
(US10584120, Compound 3)
Show SMILES O=C1NCC(N1c1ccc2[nH]cnc2c1)c1ccc(cc1)-c1nc(cs1)C1CC1
PDB
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348n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435119
PNG
(US10584120, Compound 52)
Show SMILES Cc1cc(Cn2nnc(n2)-c2ccc(cc2)C2N(C(=O)NC2=O)c2ccc3[nH]cnc3c2)on1
PDB
MMDB

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397n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435099
PNG
(US10584120, Compound 33)
Show SMILES FC(F)(F)c1ccc(s1)-c1ccc(cc1)[C@@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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736n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435079
PNG
(US10584120, Compound 10)
Show SMILES FC(F)(F)c1ncc(s1)-c1ccc(cc1)[C@@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
MMDB

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964n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435122
PNG
(US10584120, Compound 55)
Show SMILES Fc1c(F)c(ccc1[C@@H]1CNC(=O)N1c1ccc2[nH]cnc2c1)-c1csc(c1)C(F)(F)F
PDB
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1.59E+3n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435101
PNG
(US10584120, Compound 35)
Show SMILES FC(F)(F)c1cc(cs1)-c1ccc(cc1)[C@@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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2.05E+3n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
More data for this
Ligand-Target Pair
Glutaminyl-peptide cyclotransferase


(Homo sapiens (Human))
BDBM435120
PNG
(US10584120, Compound 53)
Show SMILES Fc1cc(ccc1-c1csc(c1)C(F)(F)F)[C@@H]1CNC(=O)N1c1ccc2[nH]cnc2c1
PDB
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3.42E+3n/an/an/an/an/an/an/an/a



National Health Research Institutes; Academia Sinica

US Patent


Assay Description
An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...


US Patent US10584120 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5K20
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* indicates data uncertainty>20%