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Patent code US10584134

Compile Data Set for Download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435151
PNG
(US10584134, Example 1-7)
Show SMILES C[C@H]1OC(=O)C2=C1N1CCc3ccccc3C1CC21S(=O)CCS1(=O)=O
Show InChI InChI=1S/C18H19NO5S2/c1-11-16-15(17(20)24-11)18(25(21)8-9-26(18,22)23)10-14-13-5-3-2-4-12(13)6-7-19(14)16/h2-5,11,14H,6-10H2,1H3/t11-,14?,18?,25?/m1/s1
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n/an/an/an/a 700n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435160
PNG
(US10584134, Example 2-7 | US10584134, Example 2-8)
Show SMILES COc1cnc(nc1NC(C)C(C)C)-c1ccccn1
Show InChI InChI=1S/C15H20N4O/c1-10(2)11(3)18-15-13(20-4)9-17-14(19-15)12-7-5-6-8-16-12/h5-11H,1-4H3,(H,17,18,19)
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n/an/an/an/a 100n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435163
PNG
(US10584134, Example 2-10)
Show SMILES COCC(C)Nc1nc(ncc1OC)-c1ccccn1
Show InChI InChI=1S/C14H18N4O2/c1-10(9-19-2)17-14-12(20-3)8-16-13(18-14)11-6-4-5-7-15-11/h4-8,10H,9H2,1-3H3,(H,16,17,18)
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 800n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435183
PNG
(US10584134, Example 3-8)
Show SMILES CC(C)N(C(=O)\C=C\c1ccc2OCOc2c1)c1ccccc1
Show InChI InChI=1S/C19H19NO3/c1-14(2)20(16-6-4-3-5-7-16)19(21)11-9-15-8-10-17-18(12-15)23-13-22-17/h3-12,14H,13H2,1-2H3/b11-9+
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n/an/an/an/a 600n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435184
PNG
(US10584134, Example 3-9)
Show SMILES CCCCN(C(=O)\C=C\c1ccc2OCOc2c1)c1ccccc1
Show InChI InChI=1S/C20H21NO3/c1-2-3-13-21(17-7-5-4-6-8-17)20(22)12-10-16-9-11-18-19(14-16)24-15-23-18/h4-12,14H,2-3,13,15H2,1H3/b12-10+
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n/an/an/an/a 700n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435185
PNG
(US10584134, Example 3-10)
Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H19NO3/c25-23(14-12-18-11-13-21-22(15-18)27-17-26-21)24(20-9-5-2-6-10-20)16-19-7-3-1-4-8-19/h1-15H,16-17H2/b14-12+
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435194
PNG
(US10584134, Example 3-17)
Show SMILES COc1ccc(\C=C\C(=O)N(C2CCCCC2)c2ccccn2)cc1
Show InChI InChI=1S/C21H24N2O2/c1-25-19-13-10-17(11-14-19)12-15-21(24)23(18-7-3-2-4-8-18)20-9-5-6-16-22-20/h5-6,9-16,18H,2-4,7-8H2,1H3/b15-12+
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n/an/an/an/a 400n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435196
PNG
(US10584134, Example 3-19)
Show SMILES COc1ccc(\C=C\C(=O)N(C2CCCCC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H25NO2/c1-25-21-15-12-18(13-16-21)14-17-22(24)23(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2,4-5,8-9,12-17,20H,3,6-7,10-11H2,1H3/b17-14+
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n/an/an/an/a 700n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435199
PNG
(US10584134, Example 3-22)
Show SMILES COc1ccc(\C=C\C(=O)N(C(C)C)c2ccccc2)cc1
Show InChI InChI=1S/C19H21NO2/c1-15(2)20(17-7-5-4-6-8-17)19(21)14-11-16-9-12-18(22-3)13-10-16/h4-15H,1-3H3/b14-11+
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435205
PNG
(US10584134, Example 3-27)
Show SMILES O=C(\C=C\c1ccccc1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H17NO/c23-21(17-16-18-10-4-1-5-11-18)22(19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-17H/b17-16+
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n/an/an/an/a 2.90E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435211
PNG
(US10584134, Example 3-32)
Show SMILES Cc1ccc(\C=C\C(=O)N(C2CCCCC2)c2ccccn2)cc1
Show InChI InChI=1S/C21H24N2O/c1-17-10-12-18(13-11-17)14-15-21(24)23(19-7-3-2-4-8-19)20-9-5-6-16-22-20/h5-6,9-16,19H,2-4,7-8H2,1H3/b15-14+
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435212
PNG
(US10584134, Example 3-33)
Show SMILES Cc1ccc(\C=C\C(=O)N(C2CCCCC2)C2CCCCC2)cc1
Show InChI InChI=1S/C22H31NO/c1-18-12-14-19(15-13-18)16-17-22(24)23(20-8-4-2-5-9-20)21-10-6-3-7-11-21/h12-17,20-21H,2-11H2,1H3/b17-16+
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435217
PNG
(US10584134, Example 3-39)
Show SMILES COc1cccc(\C=C\C(=O)N(C2CCCCC2)c2ccccc2)c1OC
Show InChI InChI=1S/C23H27NO3/c1-26-21-15-9-10-18(23(21)27-2)16-17-22(25)24(19-11-5-3-6-12-19)20-13-7-4-8-14-20/h3,5-6,9-12,15-17,20H,4,7-8,13-14H2,1-2H3/b17-16+
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n/an/an/an/a 2.60E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435222
PNG
(US10584134, Example 3-44)
Show SMILES O=C(COc1ccc2OCOc2c1)N(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C21H23NO4/c23-21(14-24-18-11-12-19-20(13-18)26-15-25-19)22(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1,3-4,7-8,11-13,17H,2,5-6,9-10,14-15H2
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n/an/an/an/a 1.00E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435164
PNG
(US10584134, Example 2-11)
Show SMILES COc1cnc(nc1NCC1CC1)-c1ccccn1
Show InChI InChI=1S/C14H16N4O/c1-19-12-9-17-13(11-4-2-3-7-15-11)18-14(12)16-8-10-5-6-10/h2-4,7,9-10H,5-6,8H2,1H3,(H,16,17,18)
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435166
PNG
(US10584134, Example 2-13)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C15H17N3O2/c1-19-13-11-16-14(12-5-3-2-4-6-12)17-15(13)18-7-9-20-10-8-18/h2-6,11H,7-10H2,1H3
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n/an/an/an/a 1.17E+4n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435180
PNG
(US10584134, Example 3-5)
Show SMILES CC(C)N(C1CCCCC1)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C19H25NO3/c1-14(2)20(16-6-4-3-5-7-16)19(21)11-9-15-8-10-17-18(12-15)23-13-22-17/h8-12,14,16H,3-7,13H2,1-2H3/b11-9+
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n/an/an/an/a 200n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435201
PNG
(US10584134, Example 3-24)
Show SMILES COc1ccc(\C=C\C(=O)N(Cc2ccccc2)c2ccccn2)cc1
Show InChI InChI=1S/C22H20N2O2/c1-26-20-13-10-18(11-14-20)12-15-22(25)24(21-9-5-6-16-23-21)17-19-7-3-2-4-8-19/h2-16H,17H2,1H3/b15-12+
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435203
PNG
(US10584134, Example 3-25)
Show SMILES O=C(\C=C\c1ccccc1)N(C1CCCCC1)c1ccccn1
Show InChI InChI=1S/C20H22N2O/c23-20(15-14-17-9-3-1-4-10-17)22(18-11-5-2-6-12-18)19-13-7-8-16-21-19/h1,3-4,7-10,13-16,18H,2,5-6,11-12H2/b15-14+
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n/an/an/an/a 2.30E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435213
PNG
(US10584134, Example 3-34)
Show SMILES Cc1ccc(\C=C\C(=O)N(c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C22H19NO/c1-18-12-14-19(15-13-18)16-17-22(24)23(20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2-17H,1H3/b17-16+
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n/an/an/an/a 4.00E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435147
PNG
(US10584134, Example 1-3)
Show SMILES CC1OC(=O)C2=C1N1CCc3ccccc3C1CC21SCCS1
Show InChI InChI=1S/C18H19NO2S2/c1-11-16-15(17(20)21-11)18(22-8-9-23-18)10-14-13-5-3-2-4-12(13)6-7-19(14)16/h2-5,11,14H,6-10H2,1H3
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n/an/an/an/a 700n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435142
PNG
(US10584134, Example 1-1)
Show SMILES O=C1CCCC2=C1C1(CC3N2CCc2ccccc32)SCCS1
Show InChI InChI=1S/C19H21NOS2/c21-17-7-3-6-15-18(17)19(22-10-11-23-19)12-16-14-5-2-1-4-13(14)8-9-20(15)16/h1-2,4-5,16H,3,6-12H2
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n/an/an/an/a 100n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435148
PNG
(US10584134, Example 1-4)
Show SMILES O=C1CCCC2=C1C1(CC3N2CCc2ccccc32)SCCCS1
Show InChI InChI=1S/C20H23NOS2/c22-18-8-3-7-16-19(18)20(23-11-4-12-24-20)13-17-15-6-2-1-5-14(15)9-10-21(16)17/h1-2,5-6,17H,3-4,7-13H2
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n/an/an/an/a 3.10E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 500n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435215
PNG
(US10584134, Example 3-37)
Show SMILES COc1cccc(\C=C\C(=O)N(C2CCCCC2)c2ccccn2)c1
Show InChI InChI=1S/C21H24N2O2/c1-25-19-11-7-8-17(16-19)13-14-21(24)23(18-9-3-2-4-10-18)20-12-5-6-15-22-20/h5-8,11-16,18H,2-4,9-10H2,1H3/b14-13+
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n/an/an/an/a 3.00E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435216
PNG
(US10584134, Example 3-38)
Show SMILES COc1cccc(\C=C\C(=O)N(C2CCCCC2)c2ccccn2)c1OC
Show InChI InChI=1S/C22H26N2O3/c1-26-19-12-8-9-17(22(19)27-2)14-15-21(25)24(18-10-4-3-5-11-18)20-13-6-7-16-23-20/h6-9,12-16,18H,3-5,10-11H2,1-2H3/b15-14+
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n/an/an/an/a 700n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435219
PNG
(US10584134, Example 3-41)
Show SMILES Clc1ccccc1\C=C\C(=O)N(C1CCCCC1)c1ccccn1
Show InChI InChI=1S/C20H21ClN2O/c21-18-11-5-4-8-16(18)13-14-20(24)23(17-9-2-1-3-10-17)19-12-6-7-15-22-19/h4-8,11-15,17H,1-3,9-10H2/b14-13+
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n/an/an/an/a 700n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435226
PNG
(US10584134, Example 3-48)
Show SMILES COc1ccc(cc1)C(=O)N(C1CCCCC1)c1ccccn1
Show InChI InChI=1S/C19H22N2O2/c1-23-17-12-10-15(11-13-17)19(22)21(16-7-3-2-4-8-16)18-9-5-6-14-20-18/h5-6,9-14,16H,2-4,7-8H2,1H3
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n/an/an/an/a 1.09E+4n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435182
PNG
(US10584134, Example 3-7)
Show SMILES CCCN(C(=O)\C=C\c1ccc2OCOc2c1)c1ccccc1
Show InChI InChI=1S/C19H19NO3/c1-2-12-20(16-6-4-3-5-7-16)19(21)11-9-15-8-10-17-18(13-15)23-14-22-17/h3-11,13H,2,12,14H2,1H3/b11-9+
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n/an/an/an/a 1.10E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435190
PNG
(US10584134, Example 3-13)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C20H21NO3/c1-15(2)21(13-17-6-4-3-5-7-17)20(22)11-9-16-8-10-18-19(12-16)24-14-23-18/h3-12,15H,13-14H2,1-2H3/b11-9+
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n/an/an/an/a 3.90E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435208
PNG
(US10584134, Example 3-29)
Show SMILES CC(C1CC1)N(C(=O)\C=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H21NO/c1-16(18-13-14-18)21(19-10-6-3-7-11-19)20(22)15-12-17-8-4-2-5-9-17/h2-12,15-16,18H,13-14H2,1H3/b15-12+
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n/an/an/an/a 800n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435203
PNG
(US10584134, Example 3-25)
Show SMILES O=C(\C=C\c1ccccc1)N(C1CCCCC1)c1ccccn1
Show InChI InChI=1S/C20H22N2O/c23-20(15-14-17-9-3-1-4-10-17)22(18-11-5-2-6-12-18)19-13-7-8-16-21-19/h1,3-4,7-10,13-16,18H,2,5-6,11-12H2/b15-14+
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n/an/an/an/a 4.20E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435214
PNG
(US10584134, Example 3-36)
Show SMILES CC(C)N(C(=O)\C=C\c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C19H21NO/c1-15(2)20(18-7-5-4-6-8-18)19(21)14-13-17-11-9-16(3)10-12-17/h4-15H,1-3H3/b14-13+
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n/an/an/an/a 1.80E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435218
PNG
(US10584134, Example 3-40)
Show SMILES COc1cccc(\C=C\C(=O)N(c2ccccc2)c2ccccc2)c1OC
Show InChI InChI=1S/C23H21NO3/c1-26-21-15-9-10-18(23(21)27-2)16-17-22(25)24(19-11-5-3-6-12-19)20-13-7-4-8-14-20/h3-17H,1-2H3/b17-16+
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n/an/an/an/a 5.90E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435155
PNG
(US10584134, Example 2-2)
Show SMILES COc1cnc(nc1NC1CCCC1)-c1ccccn1
Show InChI InChI=1S/C15H18N4O/c1-20-13-10-17-14(12-8-4-5-9-16-12)19-15(13)18-11-6-2-3-7-11/h4-5,8-11H,2-3,6-7H2,1H3,(H,17,18,19)
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n/an/an/an/a 300n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435156
PNG
(US10584134, Example 2-3)
Show SMILES COc1cnc(nc1NC1CCC1)-c1ccccn1
Show InChI InChI=1S/C14H16N4O/c1-19-12-9-16-13(11-7-2-3-8-15-11)18-14(12)17-10-5-4-6-10/h2-3,7-10H,4-6H2,1H3,(H,16,17,18)
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n/an/an/an/a 800n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435160
PNG
(US10584134, Example 2-7 | US10584134, Example 2-8)
Show SMILES COc1cnc(nc1NC(C)C(C)C)-c1ccccn1
Show InChI InChI=1S/C15H20N4O/c1-10(2)11(3)18-15-13(20-4)9-17-14(19-15)12-7-5-6-8-16-12/h5-11H,1-4H3,(H,17,18,19)
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n/an/an/an/a 500n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 1.60E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 300n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435197
PNG
(US10584134, Example 3-20)
Show SMILES COc1ccc(\C=C\C(=O)N(c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C22H19NO2/c1-25-21-15-12-18(13-16-21)14-17-22(24)23(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-17H,1H3/b17-14+
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n/an/an/an/a 1.10E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435204
PNG
(US10584134, Example 3-26)
Show SMILES O=C(\C=C\c1ccccc1)N(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C21H23NO/c23-21(17-16-18-10-4-1-5-11-18)22(19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-2,4-7,10-13,16-17,20H,3,8-9,14-15H2/b17-16+
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n/an/an/an/a 600n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435210
PNG
(US10584134, Example 3-31)
Show SMILES Cc1cccc(\C=C\C(=O)N(C2CCCCC2)c2ccccn2)c1
Show InChI InChI=1S/C21H24N2O/c1-17-8-7-9-18(16-17)13-14-21(24)23(19-10-3-2-4-11-19)20-12-5-6-15-22-20/h5-9,12-16,19H,2-4,10-11H2,1H3/b14-13+
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n/an/an/an/a 300n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435221
PNG
(US10584134, Example 3-43)
Show SMILES O=C(CCc1ccc2OCOc2c1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H19NO3/c24-22(14-12-17-11-13-20-21(15-17)26-16-25-20)23(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-11,13,15H,12,14,16H2
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n/an/an/an/a 6.80E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435225
PNG
(US10584134, Example 3-47)
Show SMILES Cc1ccccc1N(Cc1ccccc1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C22H21NO/c1-18-10-8-9-15-21(18)23(17-20-13-6-3-7-14-20)22(24)16-19-11-4-2-5-12-19/h2-15H,16-17H2,1H3
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435227
PNG
(US10584134, Example 3-49)
Show SMILES Clc1cccc(Cl)c1C(=O)N(Cc1ccccc1)c1ccccn1
Show InChI InChI=1S/C19H14Cl2N2O/c20-15-9-6-10-16(21)18(15)19(24)23(17-11-4-5-12-22-17)13-14-7-2-1-3-8-14/h1-12H,13H2
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n/an/an/an/a 5.50E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435152
PNG
(US10584134, Example 1-8)
Show SMILES CC1(C)CC(=O)C2=C(C1)N1CCc3ccccc3C1CC21S(=O)CCS1(=O)=O
Show InChI InChI=1S/C21H25NO4S2/c1-20(2)11-17-19(18(23)13-20)21(27(24)9-10-28(21,25)26)12-16-15-6-4-3-5-14(15)7-8-22(16)17/h3-6,16H,7-13H2,1-2H3
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n/an/an/an/a 9.80E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435153
PNG
(US10584134, Example 1-9)
Show SMILES C[C@H]1OC(=O)C2=C1N1CCc3ccccc3C1CC2=O
Show InChI InChI=1S/C16H15NO3/c1-9-15-14(16(19)20-9)13(18)8-12-11-5-3-2-4-10(11)6-7-17(12)15/h2-5,9,12H,6-8H2,1H3/t9-,12?/m1/s1
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SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435162
PNG
(US10584134, Example 2-9)
Show SMILES COc1cnc(nc1NC(C)CCO)-c1ccccn1
Show InChI InChI=1S/C14H18N4O2/c1-10(6-8-19)17-14-12(20-2)9-16-13(18-14)11-5-3-4-7-15-11/h3-5,7,9-10,19H,6,8H2,1-2H3,(H,16,17,18)
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n/an/an/an/a 1.00E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 300n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435181
PNG
(US10584134, Example 3-6)
Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H17NO3/c24-22(14-12-17-11-13-20-21(15-17)26-16-25-20)23(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-15H,16H2/b14-12+
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n/an/an/an/a 800n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435195
PNG
(US10584134, Example 3-18)
Show SMILES COc1ccc(\C=C\C(=O)N(C2CCCCC2)C2CCCCC2)cc1
Show InChI InChI=1S/C22H31NO2/c1-25-21-15-12-18(13-16-21)14-17-22(24)23(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h12-17,19-20H,2-11H2,1H3/b17-14+
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n/an/an/an/a 100n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435198
PNG
(US10584134, Example 3-21)
Show SMILES CCCN(C(=O)\C=C\c1ccc(OC)cc1)c1ccccc1
Show InChI InChI=1S/C19H21NO2/c1-3-15-20(17-7-5-4-6-8-17)19(21)14-11-16-9-12-18(22-2)13-10-16/h4-14H,3,15H2,1-2H3/b14-11+
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n/an/an/an/a 1.70E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435223
PNG
(US10584134, Example 3-45)
Show SMILES COc1ccc(OCC(=O)N(C2CCCCC2)c2ccccn2)cc1
Show InChI InChI=1S/C20H24N2O3/c1-24-17-10-12-18(13-11-17)25-15-20(23)22(16-7-3-2-4-8-16)19-9-5-6-14-21-19/h5-6,9-14,16H,2-4,7-8,15H2,1H3
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n/an/an/an/a 4.00E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435143
PNG
(US10584134, Example 1-2)
Show SMILES CC1(C)CC(=O)C2=C(C1)N1CCc3ccccc3C1CC21SCCS1
Show InChI InChI=1S/C21H25NOS2/c1-20(2)11-17-19(18(23)13-20)21(24-9-10-25-21)12-16-15-6-4-3-5-14(15)7-8-22(16)17/h3-6,16H,7-13H2,1-2H3
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n/an/an/an/a 600n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435150
PNG
(US10584134, Example 1-6)
Show SMILES C[C@H]1OC(=O)C2=C1N1CCc3ccccc3C1CC21SCCCS1
Show InChI InChI=1S/C19H21NO2S2/c1-12-17-16(18(21)22-12)19(23-9-4-10-24-19)11-15-14-6-3-2-5-13(14)7-8-20(15)17/h2-3,5-6,12,15H,4,7-11H2,1H3/t12-,15?/m1/s1
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n/an/an/an/a 200n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 100n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435159
PNG
(US10584134, Example 2-5)
Show SMILES CC[C@@H](C)Nc1nc(ncc1OC)-c1ccccn1
Show InChI InChI=1S/C14H18N4O/c1-4-10(2)17-14-12(19-3)9-16-13(18-14)11-7-5-6-8-15-11/h5-10H,4H2,1-3H3,(H,16,17,18)/t10-/m1/s1
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n/an/an/an/a 100n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435165
PNG
(US10584134, Example 2-12)
Show SMILES COc1cnc(nc1OC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H15N3O2/c1-9(2)18-13-11(17-3)8-15-12(16-13)10-6-4-5-7-14-10/h4-9H,1-3H3
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n/an/an/an/a 3.20E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435167
PNG
(US10584134, Example 2-14)
Show SMILES CCc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C14H18N4/c1-4-11-9-16-14(12-7-5-6-8-15-12)18-13(11)17-10(2)3/h5-10H,4H2,1-3H3,(H,16,17,18)
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n/an/an/an/a 400n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 700n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435176
PNG
(US10584134, Example 3-1)
Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(C1CCCCC1)c1ccccn1
Show InChI InChI=1S/C21H22N2O3/c24-21(12-10-16-9-11-18-19(14-16)26-15-25-18)23(17-6-2-1-3-7-17)20-8-4-5-13-22-20/h4-5,8-14,17H,1-3,6-7,15H2/b12-10+
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n/an/an/an/a 100n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435178
PNG
(US10584134, Example 3-3)
Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C22H23NO3/c24-22(14-12-17-11-13-20-21(15-17)26-16-25-20)23(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1,3-4,7-8,11-15,19H,2,5-6,9-10,16H2/b14-12+
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n/an/an/an/a 900n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435187
PNG
(US10584134, Example 3-11)
Show SMILES CCN(C(=O)\C=C\c1ccc2OCOc2c1)c1ccccn1
Show InChI InChI=1S/C17H16N2O3/c1-2-19(16-5-3-4-10-18-16)17(20)9-7-13-6-8-14-15(11-13)22-12-21-14/h3-11H,2,12H2,1H3/b9-7+
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n/an/an/an/a 6.20E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435191
PNG
(US10584134, Example 3-14)
Show SMILES CCN(Cc1ccccc1)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C19H19NO3/c1-2-20(13-16-6-4-3-5-7-16)19(21)11-9-15-8-10-17-18(12-15)23-14-22-17/h3-12H,2,13-14H2,1H3/b11-9+
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n/an/an/an/a 1.50E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435200
PNG
(US10584134, Example 3-23)
Show SMILES COc1ccc(\C=C\C(=O)N(Cc2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C23H21NO2/c1-26-22-15-12-19(13-16-22)14-17-23(25)24(21-10-6-3-7-11-21)18-20-8-4-2-5-9-20/h2-17H,18H2,1H3/b17-14+
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n/an/an/an/a 3.20E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435207
PNG
(US10584134, Example 3-28)
Show SMILES O=C(\C=C\c1ccccc1)N(Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H19NO/c24-22(17-16-19-10-4-1-5-11-19)23(21-14-8-3-9-15-21)18-20-12-6-2-7-13-20/h1-17H,18H2/b17-16+
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n/an/an/an/a 2.40E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435209
PNG
(US10584134, Example 3-30)
Show SMILES Cc1ccccc1\C=C\C(=O)N(C1CCCCC1)c1ccccn1
Show InChI InChI=1S/C21H24N2O/c1-17-9-5-6-10-18(17)14-15-21(24)23(19-11-3-2-4-12-19)20-13-7-8-16-22-20/h5-10,13-16,19H,2-4,11-12H2,1H3/b15-14+
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n/an/an/an/a 400n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435220
PNG
(US10584134, Example 3-42)
Show SMILES COc1ccc(CCC(=O)N(C2CCCCC2)c2ccccn2)cc1
Show InChI InChI=1S/C21H26N2O2/c1-25-19-13-10-17(11-14-19)12-15-21(24)23(18-7-3-2-4-8-18)20-9-5-6-16-22-20/h5-6,9-11,13-14,16,18H,2-4,7-8,12,15H2,1H3
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n/an/an/an/a 3.30E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435149
PNG
(US10584134, Example 1-5)
Show SMILES CC1(C)CC(=O)C2=C(C1)N1CCc3ccccc3C1CC21SCCCS1
Show InChI InChI=1S/C22H27NOS2/c1-21(2)12-18-20(19(24)14-21)22(25-10-5-11-26-22)13-17-16-7-4-3-6-15(16)8-9-23(17)18/h3-4,6-7,17H,5,8-14H2,1-2H3
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n/an/an/an/a 1.40E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435157
PNG
(US10584134, Example 2-4)
Show SMILES COc1cnc(nc1N1CCOCC1)-c1ccccn1
Show InChI InChI=1S/C14H16N4O2/c1-19-12-10-16-13(11-4-2-3-5-15-11)17-14(12)18-6-8-20-9-7-18/h2-5,10H,6-9H2,1H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 400n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435154
PNG
(US10584134, Example 2-1 | US10584134, Example 2-15...)
Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1
Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)
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n/an/an/an/a 900n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435177
PNG
(US10584134, Example 3-2)
Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(C1CCCCC1)C1CCCCC1
Show InChI InChI=1S/C22H29NO3/c24-22(14-12-17-11-13-20-21(15-17)26-16-25-20)23(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h11-15,18-19H,1-10,16H2/b14-12+
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n/an/an/an/a 1.18E+4n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435179
PNG
(US10584134, Example 3-4)
Show SMILES CCN(C1CCCCC1)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C18H23NO3/c1-2-19(15-6-4-3-5-7-15)18(20)11-9-14-8-10-16-17(12-14)22-13-21-16/h8-12,15H,2-7,13H2,1H3/b11-9+
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n/an/an/an/a 800n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435188
PNG
(US10584134, Example 3-12)
Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(Cc1ccccc1)c1ccccn1
Show InChI InChI=1S/C22H18N2O3/c25-22(12-10-17-9-11-19-20(14-17)27-16-26-19)24(21-8-4-5-13-23-21)15-18-6-2-1-3-7-18/h1-14H,15-16H2/b12-10+
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n/an/an/an/a 700n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435192
PNG
(US10584134, Example 3-15)
Show SMILES CCN(CC)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C14H17NO3/c1-3-15(4-2)14(16)8-6-11-5-7-12-13(9-11)18-10-17-12/h5-9H,3-4,10H2,1-2H3/b8-6+
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n/an/an/an/a 1.23E+4n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435193
PNG
(US10584134, Example 3-16)
Show SMILES CC(C)CN(C(=O)\C=C\c1ccc2OCOc2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H20ClNO3/c1-14(2)12-22(17-7-5-16(21)6-8-17)20(23)10-4-15-3-9-18-19(11-15)25-13-24-18/h3-11,14H,12-13H2,1-2H3/b10-4+
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n/an/an/an/a 8.20E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM435224
PNG
(US10584134, Example 3-46)
Show SMILES O=C(COc1ccccc1)N(C1CCCCC1)c1nccs1
Show InChI InChI=1S/C17H20N2O2S/c20-16(13-21-15-9-5-2-6-10-15)19(17-18-11-12-22-17)14-7-3-1-4-8-14/h2,5-6,9-12,14H,1,3-4,7-8,13H2
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n/an/an/an/a 3.00E+3n/an/an/an/a



SYMRISE AG; BASF SE

US Patent


Assay Description
A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...


US Patent US10584134 (2020)


BindingDB Entry DOI: 10.7270/Q2FJ2K56
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%