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Patent code US10590077

Compile Data Set for Download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM436106
PNG
(4-(((3S,4S)-4-(aminomethyl)-1-((5-chloropyridin-2-...)
Show SMILES NC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cn1
Show InChI InChI=1S/C18H18ClFN4O3S/c19-15-3-4-17(23-8-15)28(26,27)24-9-14(18(25,10-22)11-24)5-12-1-2-13(7-21)16(20)6-12/h1-4,6,8,14,25H,5,9-11,22H2/t14-,18-/m0/s1
PDB

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GlaxoSmithKline Intellectual Property Development Limited

US Patent


Assay Description
TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...


US Patent US10590077 (2020)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM436099
PNG
(4-(((3S,4R)-1-((2,4-dichlorophenyl)sulfonyl)-4-hyd...)
Show SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H17Cl2FN2O4S/c20-15-3-4-18(16(21)7-15)29(27,28)24-9-14(19(26,10-24)11-25)5-12-1-2-13(8-23)17(22)6-12/h1-4,6-7,14,25-26H,5,9-11H2/t14-,19+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property Development Limited

US Patent


Assay Description
TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...


US Patent US10590077 (2020)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM436104
PNG
(4-(((3S,4R)-1- ((2-cyano-4- (trifluoromethyl) phen...)
Show SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(cc1C#N)C(F)(F)F
Show InChI InChI=1S/C21H17F4N3O4S/c22-18-6-13(1-2-14(18)8-26)5-17-10-28(11-20(17,30)12-29)33(31,32)19-4-3-16(21(23,24)25)7-15(19)9-27/h1-4,6-7,17,29-30H,5,10-12H2/t17-,20+/m0/s1
PDB

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GlaxoSmithKline Intellectual Property Development Limited

US Patent


Assay Description
TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...


US Patent US10590077 (2020)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM436105
PNG
(4-(((3S,4R)-1- ((2-chloro-4- cyanophenyl) sulfonyl...)
Show SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(cc1Cl)C#N
Show InChI InChI=1S/C20H17ClFN3O4S/c21-17-6-14(8-23)2-4-19(17)30(28,29)25-10-16(20(27,11-25)12-26)5-13-1-3-15(9-24)18(22)7-13/h1-4,6-7,16,26-27H,5,10-12H2/t16-,20+/m0/s1
PDB

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GlaxoSmithKline Intellectual Property Development Limited

US Patent


Assay Description
TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...


US Patent US10590077 (2020)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM436100
PNG
(4-(((3S,4R)-1- ((2-chloro-4- (trifluoromethyl) phe...)
Show SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(cc1)C#N)S(=O)(=O)c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C20H18ClF3N2O4S/c21-17-8-15(20(22,23)24)5-6-18(17)31(29,30)26-10-16(19(28,11-26)12-27)7-13-1-3-14(9-25)4-2-13/h1-6,8,16,27-28H,7,10-12H2/t16-,19+/m0/s1
PDB

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n/an/a 55n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property Development Limited

US Patent


Assay Description
TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...


US Patent US10590077 (2020)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM436101
PNG
(4-(((3S,4R)-1- ((5-chloropyridin- 2-yl)sulfonyl)-4...)
Show SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(cc1OCC(F)(F)F)C#N)S(=O)(=O)c1ccc(Cl)cn1
Show InChI InChI=1S/C20H19ClF3N3O5S/c21-16-3-4-18(26-8-16)33(30,31)27-9-15(19(29,10-27)11-28)6-14-2-1-13(7-25)5-17(14)32-12-20(22,23)24/h1-5,8,15,28-29H,6,9-12H2/t15-,19+/m0/s1
PDB

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n/an/a 55n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property Development Limited

US Patent


Assay Description
TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...


US Patent US10590077 (2020)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM436103
PNG
(4-(((3S,4S)-1- ((2,4- dichlorophenyl) sulfonyl)-4-...)
Show SMILES OC[C@@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H17Cl2FN2O4S/c20-15-3-4-18(16(21)7-15)29(27,28)24-9-14(19(26,10-24)11-25)5-12-1-2-13(8-23)17(22)6-12/h1-4,6-7,14,25-26H,5,9-11H2/t14-,19-/m0/s1
PDB

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n/an/a 55n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property Development Limited

US Patent


Assay Description
TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...


US Patent US10590077 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%