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Patent code US10590109

Compile Data Set for Download or QSAR
Found 85 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436192
PNG
(US10590109, Compound 10)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H25N7O4/c1-14(2)25-17-8-19(24-10-16(17)9-23)27-22(32)28(3)20-5-4-15(18(12-30)26-20)11-29-6-7-33-13-21(29)31/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H2,24,25,27,32)
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US Patent
n/an/a<10n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436194
PNG
(US10590109, Compound 12)
Show SMILES COCCOc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H24N6O6/c1-27(22(31)26-19-9-18(34-8-7-32-2)16(10-23)11-24-19)20-4-3-15(17(13-29)25-20)12-28-5-6-33-14-21(28)30/h3-4,9,11,13H,5-8,12,14H2,1-2H3,(H,24,26,31)
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n/an/a<10n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436187
PNG
(US10590109, Compound 5)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2cccc(C=O)n2)ncc1C#N
Show InChI InChI=1S/C17H18N6O2/c1-11(2)20-14-7-15(19-9-12(14)8-18)22-17(25)23(3)16-6-4-5-13(10-24)21-16/h4-7,9-11H,1-3H3,(H2,19,20,22,25)
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US Patent
n/an/a<10n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436200
PNG
(US10590109, Compound 18 | US10590109, Compound 25)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436191
PNG
(US10590109, Compound 9)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H25N7O5/c1-28(22(32)27-19-9-17(24-5-7-33-2)16(10-23)11-25-19)20-4-3-15(18(13-30)26-20)12-29-6-8-34-14-21(29)31/h3-4,9,11,13H,5-8,12,14H2,1-2H3,(H2,24,25,27,32)
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n/an/a<10n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436189
PNG
(US10590109, Compound 7)
Show SMILES COCCOc1cc(NC(=O)N(C)c2cccc(C=O)n2)ncc1C#N
Show InChI InChI=1S/C17H17N5O4/c1-22(16-5-3-4-13(11-23)20-16)17(24)21-15-8-14(26-7-6-25-2)12(9-18)10-19-15/h3-5,8,10-11H,6-7H2,1-2H3,(H,19,21,24)
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n/an/a<10n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436197
PNG
(US10590109, Compound 15 | US10590109, Compound 20)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)
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n/an/a<10n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436198
PNG
(US10590109, Compound 16)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O3/c1-15(2)26-18-9-20(25-11-17(18)10-24)28-23(34)30(4)21-6-5-16(19(14-32)27-21)12-31-8-7-29(3)13-22(31)33/h5-6,9,11,14-15H,7-8,12-13H2,1-4H3,(H2,25,26,28,34)
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436188
PNG
(US10590109, Compound 6)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2cccc(C=O)n2)ncc1C#N
Show InChI InChI=1S/C17H17N5O3/c1-11(2)25-14-7-15(19-9-12(14)8-18)21-17(24)22(3)16-6-4-5-13(10-23)20-16/h4-7,9-11H,1-3H3,(H,19,21,24)
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436208
PNG
(US10590109, Compound 26)
Show SMILES C[C@@H](CO)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H27N7O5/c1-15(13-31)35-19-8-20(25-10-17(19)9-24)27-23(34)29(3)21-5-4-16(18(14-32)26-21)11-30-7-6-28(2)12-22(30)33/h4-5,8,10,14-15,31H,6-7,11-13H2,1-3H3,(H,25,27,34)/t15-/m0/s1
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436174
PNG
(US10590109, Compound 1)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Oc2ccc3nccnc3c2)c1
Show InChI InChI=1S/C22H14F3N3O2/c23-22(24,25)15-4-1-3-14(11-15)21(29)28-16-5-2-6-17(12-16)30-18-7-8-19-20(13-18)27-10-9-26-19/h1-13H,(H,28,29)
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436196
PNG
(US10590109, Compound 14)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H26N6O6/c1-15(13-33-3)35-19-8-20(25-10-17(19)9-24)27-23(32)28(2)21-5-4-16(18(12-30)26-21)11-29-6-7-34-14-22(29)31/h4-5,8,10,12,15H,6-7,11,13-14H2,1-3H3,(H,25,27,32)/t15-/m1/s1
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436206
PNG
(US10590109, Compound 24)
Show SMILES COC[C@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m0/s1
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436201
PNG
(US10590109, Compound 19)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H27N7O4/c1-15(2)34-19-9-20(25-11-17(19)10-24)27-23(33)29(4)21-6-5-16(18(14-31)26-21)12-30-8-7-28(3)13-22(30)32/h5-6,9,11,14-15H,7-8,12-13H2,1-4H3,(H,25,27,33)
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436200
PNG
(US10590109, Compound 18 | US10590109, Compound 25)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m1/s1
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436195
PNG
(US10590109, Compound 13)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H24N6O5/c1-14(2)33-18-8-19(24-10-16(18)9-23)26-22(31)27(3)20-5-4-15(17(12-29)25-20)11-28-6-7-32-13-21(28)30/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H,24,26,31)
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436193
PNG
(US10590109, Compound 11)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCOCC2=O)c(C=O)n1
Show InChI InChI=1S/C19H17ClN6O4/c1-25(19(29)24-16-6-14(20)13(7-21)8-22-16)17-3-2-12(15(10-27)23-17)9-26-4-5-30-11-18(26)28/h2-3,6,8,10H,4-5,9,11H2,1H3,(H,22,24,29)
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n/an/a 55n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436204
PNG
(US10590109, Compound 23)
Show SMILES COCCOc1cc(NC(=O)N(C)c2ccc(C3CCNCC3)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H26N6O4/c1-28(21-4-3-17(18(14-29)26-21)15-5-7-24-8-6-15)22(30)27-20-11-19(32-10-9-31-2)16(12-23)13-25-20/h3-4,11,13-15,24H,5-10H2,1-2H3,(H,25,27,30)
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n/an/a 55n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436197
PNG
(US10590109, Compound 15 | US10590109, Compound 20)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)
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n/an/a 55n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436184
PNG
(US10590109, Compound 3)
Show SMILES CN(C(=O)Nc1ccc(cn1)C#C)c1cccc(C=O)n1
Show InChI InChI=1S/C15H12N4O2/c1-3-11-7-8-13(16-9-11)18-15(21)19(2)14-6-4-5-12(10-20)17-14/h1,4-10H,2H3,(H,16,18,21)
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n/an/a 55n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436190
PNG
(US10590109, Compound 8)
Show SMILES COCCNc1cc(NC(=O)N(C)c2nccc(C=O)n2)ncc1C#N
Show InChI InChI=1S/C16H17N7O3/c1-23(15-19-4-3-12(10-24)21-15)16(25)22-14-7-13(18-5-6-26-2)11(8-17)9-20-14/h3-4,7,9-10H,5-6H2,1-2H3,(H2,18,20,22,25)
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n/an/a 550n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436205
PNG
(US10590109, Compound 22)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CO)c(C=O)n1
Show InChI InChI=1S/C15H12ClN5O3/c1-21(14-3-2-9(7-22)12(8-23)19-14)15(24)20-13-4-11(16)10(5-17)6-18-13/h2-4,6,8,22H,7H2,1H3,(H,18,20,24)
PDB
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US Patent
n/an/a 550n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436185
PNG
(US10590109, Compound 4)
Show SMILES CN(C(=O)Nc1cc(Cl)ccn1)c1cccc(C=O)n1
Show InChI InChI=1S/C13H11ClN4O2/c1-18(12-4-2-3-10(8-19)16-12)13(20)17-11-7-9(14)5-6-15-11/h2-8H,1H3,(H,15,17,20)
PDB
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US Patent
n/an/a 550n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436183
PNG
(US10590109, Compound 2)
Show SMILES CN(C(=O)Nc1cc(Cl)ncn1)c1cccc(C=O)n1
Show InChI InChI=1S/C12H10ClN5O2/c1-18(11-4-2-3-8(6-19)16-11)12(20)17-10-5-9(13)14-7-15-10/h2-7H,1H3,(H,14,15,17,20)
PDB
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US Patent
n/an/a 550n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436199
PNG
(US10590109, Compound 17)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCN(C)CC2=O)c(C=O)n1
Show InChI InChI=1S/C20H20ClN7O3/c1-26-5-6-28(19(30)11-26)10-13-3-4-18(24-16(13)12-29)27(2)20(31)25-17-7-15(21)14(8-22)9-23-17/h3-4,7,9,12H,5-6,10-11H2,1-2H3,(H,23,25,31)
PDB
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n/an/a 550n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802)


(Homo sapiens (Human))
BDBM436203
PNG
(US10590109, Compound 21)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CO)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C18H20N6O4/c1-24(17-4-3-12(10-25)15(11-26)22-17)18(27)23-16-7-14(20-5-6-28-2)13(8-19)9-21-16/h3-4,7,9,11,25H,5-6,10H2,1-2H3,(H2,20,21,23,27)
PDB
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n/an/a 550n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436189
PNG
(US10590109, Compound 7)
Show SMILES COCCOc1cc(NC(=O)N(C)c2cccc(C=O)n2)ncc1C#N
Show InChI InChI=1S/C17H17N5O4/c1-22(16-5-3-4-13(11-23)20-16)17(24)21-15-8-14(26-7-6-25-2)12(9-18)10-19-15/h3-5,8,10-11H,6-7H2,1-2H3,(H,19,21,24)
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436191
PNG
(US10590109, Compound 9)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H25N7O5/c1-28(22(32)27-19-9-17(24-5-7-33-2)16(10-23)11-25-19)20-4-3-15(18(13-30)26-20)12-29-6-8-34-14-21(29)31/h3-4,9,11,13H,5-8,12,14H2,1-2H3,(H2,24,25,27,32)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436191
PNG
(US10590109, Compound 9)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H25N7O5/c1-28(22(32)27-19-9-17(24-5-7-33-2)16(10-23)11-25-19)20-4-3-15(18(13-30)26-20)12-29-6-8-34-14-21(29)31/h3-4,9,11,13H,5-8,12,14H2,1-2H3,(H2,24,25,27,32)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436193
PNG
(US10590109, Compound 11)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCOCC2=O)c(C=O)n1
Show InChI InChI=1S/C19H17ClN6O4/c1-25(19(29)24-16-6-14(20)13(7-21)8-22-16)17-3-2-12(15(10-27)23-17)9-26-4-5-30-11-18(26)28/h2-3,6,8,10H,4-5,9,11H2,1H3,(H,22,24,29)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436194
PNG
(US10590109, Compound 12)
Show SMILES COCCOc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H24N6O6/c1-27(22(31)26-19-9-18(34-8-7-32-2)16(10-23)11-24-19)20-4-3-15(17(13-29)25-20)12-28-5-6-33-14-21(28)30/h3-4,9,11,13H,5-8,12,14H2,1-2H3,(H,24,26,31)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436194
PNG
(US10590109, Compound 12)
Show SMILES COCCOc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H24N6O6/c1-27(22(31)26-19-9-18(34-8-7-32-2)16(10-23)11-24-19)20-4-3-15(17(13-29)25-20)12-28-5-6-33-14-21(28)30/h3-4,9,11,13H,5-8,12,14H2,1-2H3,(H,24,26,31)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436197
PNG
(US10590109, Compound 15 | US10590109, Compound 20)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436199
PNG
(US10590109, Compound 17)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCN(C)CC2=O)c(C=O)n1
Show InChI InChI=1S/C20H20ClN7O3/c1-26-5-6-28(19(30)11-26)10-13-3-4-18(24-16(13)12-29)27(2)20(31)25-17-7-15(21)14(8-22)9-23-17/h3-4,7,9,12H,5-6,10-11H2,1-2H3,(H,23,25,31)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436199
PNG
(US10590109, Compound 17)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCN(C)CC2=O)c(C=O)n1
Show InChI InChI=1S/C20H20ClN7O3/c1-26-5-6-28(19(30)11-26)10-13-3-4-18(24-16(13)12-29)27(2)20(31)25-17-7-15(21)14(8-22)9-23-17/h3-4,7,9,12H,5-6,10-11H2,1-2H3,(H,23,25,31)
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436199
PNG
(US10590109, Compound 17)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCN(C)CC2=O)c(C=O)n1
Show InChI InChI=1S/C20H20ClN7O3/c1-26-5-6-28(19(30)11-26)10-13-3-4-18(24-16(13)12-29)27(2)20(31)25-17-7-15(21)14(8-22)9-23-17/h3-4,7,9,12H,5-6,10-11H2,1-2H3,(H,23,25,31)
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436197
PNG
(US10590109, Compound 15 | US10590109, Compound 20)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436208
PNG
(US10590109, Compound 26)
Show SMILES C[C@@H](CO)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H27N7O5/c1-15(13-31)35-19-8-20(25-10-17(19)9-24)27-23(34)29(3)21-5-4-16(18(14-32)26-21)11-30-7-6-28(2)12-22(30)33/h4-5,8,10,14-15,31H,6-7,11-13H2,1-3H3,(H,25,27,34)/t15-/m0/s1
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436208
PNG
(US10590109, Compound 26)
Show SMILES C[C@@H](CO)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H27N7O5/c1-15(13-31)35-19-8-20(25-10-17(19)9-24)27-23(34)29(3)21-5-4-16(18(14-32)26-21)11-30-7-6-28(2)12-22(30)33/h4-5,8,10,14-15,31H,6-7,11-13H2,1-3H3,(H,25,27,34)/t15-/m0/s1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436174
PNG
(US10590109, Compound 1)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Oc2ccc3nccnc3c2)c1
Show InChI InChI=1S/C22H14F3N3O2/c23-22(24,25)15-4-1-3-14(11-15)21(29)28-16-5-2-6-17(12-16)30-18-7-8-19-20(13-18)27-10-9-26-19/h1-13H,(H,28,29)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436192
PNG
(US10590109, Compound 10)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H25N7O4/c1-14(2)25-17-8-19(24-10-16(17)9-23)27-22(32)28(3)20-5-4-15(18(12-30)26-20)11-29-6-7-33-13-21(29)31/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H2,24,25,27,32)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436196
PNG
(US10590109, Compound 14)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H26N6O6/c1-15(13-33-3)35-19-8-20(25-10-17(19)9-24)27-23(32)28(2)21-5-4-16(18(12-30)26-21)11-29-6-7-34-14-22(29)31/h4-5,8,10,12,15H,6-7,11,13-14H2,1-3H3,(H,25,27,32)/t15-/m1/s1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436198
PNG
(US10590109, Compound 16)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O3/c1-15(2)26-18-9-20(25-11-17(18)10-24)28-23(34)30(4)21-6-5-16(19(14-32)27-21)12-31-8-7-29(3)13-22(31)33/h5-6,9,11,14-15H,7-8,12-13H2,1-4H3,(H2,25,26,28,34)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436200
PNG
(US10590109, Compound 18 | US10590109, Compound 25)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m1/s1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436201
PNG
(US10590109, Compound 19)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H27N7O4/c1-15(2)34-19-9-20(25-11-17(19)10-24)27-23(33)29(4)21-6-5-16(18(14-31)26-21)12-30-8-7-28(3)13-22(30)32/h5-6,9,11,14-15H,7-8,12-13H2,1-4H3,(H,25,27,33)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436204
PNG
(US10590109, Compound 23)
Show SMILES COCCOc1cc(NC(=O)N(C)c2ccc(C3CCNCC3)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H26N6O4/c1-28(21-4-3-17(18(14-29)26-21)15-5-7-24-8-6-15)22(30)27-20-11-19(32-10-9-31-2)16(12-23)13-25-20/h3-4,11,13-15,24H,5-10H2,1-2H3,(H,25,27,30)
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436200
PNG
(US10590109, Compound 18 | US10590109, Compound 25)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m1/s1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436200
PNG
(US10590109, Compound 18 | US10590109, Compound 25)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m1/s1
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436200
PNG
(US10590109, Compound 18 | US10590109, Compound 25)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m1/s1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436201
PNG
(US10590109, Compound 19)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H27N7O4/c1-15(2)34-19-9-20(25-11-17(19)10-24)27-23(33)29(4)21-6-5-16(18(14-31)26-21)12-30-8-7-28(3)13-22(30)32/h5-6,9,11,14-15H,7-8,12-13H2,1-4H3,(H,25,27,33)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436197
PNG
(US10590109, Compound 15 | US10590109, Compound 20)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436206
PNG
(US10590109, Compound 24)
Show SMILES COC[C@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m0/s1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436204
PNG
(US10590109, Compound 23)
Show SMILES COCCOc1cc(NC(=O)N(C)c2ccc(C3CCNCC3)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H26N6O4/c1-28(21-4-3-17(18(14-29)26-21)15-5-7-24-8-6-15)22(30)27-20-11-19(32-10-9-31-2)16(12-23)13-25-20/h3-4,11,13-15,24H,5-10H2,1-2H3,(H,25,27,30)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436183
PNG
(US10590109, Compound 2)
Show SMILES CN(C(=O)Nc1cc(Cl)ncn1)c1cccc(C=O)n1
Show InChI InChI=1S/C12H10ClN5O2/c1-18(11-4-2-3-8(6-19)16-11)12(20)17-10-5-9(13)14-7-15-10/h2-7H,1H3,(H,14,15,17,20)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436187
PNG
(US10590109, Compound 5)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2cccc(C=O)n2)ncc1C#N
Show InChI InChI=1S/C17H18N6O2/c1-11(2)20-14-7-15(19-9-12(14)8-18)22-17(25)23(3)16-6-4-5-13(10-24)21-16/h4-7,9-11H,1-3H3,(H2,19,20,22,25)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436190
PNG
(US10590109, Compound 8)
Show SMILES COCCNc1cc(NC(=O)N(C)c2nccc(C=O)n2)ncc1C#N
Show InChI InChI=1S/C16H17N7O3/c1-23(15-19-4-3-12(10-24)21-15)16(25)22-14-7-13(18-5-6-26-2)11(8-17)9-20-14/h3-4,7,9-10H,5-6H2,1-2H3,(H2,18,20,22,25)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436192
PNG
(US10590109, Compound 10)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H25N7O4/c1-14(2)25-17-8-19(24-10-16(17)9-23)27-22(32)28(3)20-5-4-15(18(12-30)26-20)11-29-6-7-33-13-21(29)31/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H2,24,25,27,32)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436200
PNG
(US10590109, Compound 18 | US10590109, Compound 25)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m1/s1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436201
PNG
(US10590109, Compound 19)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H27N7O4/c1-15(2)34-19-9-20(25-11-17(19)10-24)27-23(33)29(4)21-6-5-16(18(14-31)26-21)12-30-8-7-28(3)13-22(30)32/h5-6,9,11,14-15H,7-8,12-13H2,1-4H3,(H,25,27,33)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436197
PNG
(US10590109, Compound 15 | US10590109, Compound 20)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436205
PNG
(US10590109, Compound 22)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CO)c(C=O)n1
Show InChI InChI=1S/C15H12ClN5O3/c1-21(14-3-2-9(7-22)12(8-23)19-14)15(24)20-13-4-11(16)10(5-17)6-18-13/h2-4,6,8,22H,7H2,1H3,(H,18,20,24)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436208
PNG
(US10590109, Compound 26)
Show SMILES C[C@@H](CO)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H27N7O5/c1-15(13-31)35-19-8-20(25-10-17(19)9-24)27-23(34)29(3)21-5-4-16(18(14-32)26-21)11-30-7-6-28(2)12-22(30)33/h4-5,8,10,14-15,31H,6-7,11-13H2,1-3H3,(H,25,27,34)/t15-/m0/s1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436185
PNG
(US10590109, Compound 4)
Show SMILES CN(C(=O)Nc1cc(Cl)ccn1)c1cccc(C=O)n1
Show InChI InChI=1S/C13H11ClN4O2/c1-18(12-4-2-3-10(8-19)16-12)13(20)17-11-7-9(14)5-6-15-11/h2-8H,1H3,(H,15,17,20)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436192
PNG
(US10590109, Compound 10)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H25N7O4/c1-14(2)25-17-8-19(24-10-16(17)9-23)27-22(32)28(3)20-5-4-15(18(12-30)26-20)11-29-6-7-33-13-21(29)31/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H2,24,25,27,32)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436195
PNG
(US10590109, Compound 13)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H24N6O5/c1-14(2)33-18-8-19(24-10-16(18)9-23)26-22(31)27(3)20-5-4-15(17(12-29)25-20)11-28-6-7-32-13-21(28)30/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H,24,26,31)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436196
PNG
(US10590109, Compound 14)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H26N6O6/c1-15(13-33-3)35-19-8-20(25-10-17(19)9-24)27-23(32)28(2)21-5-4-16(18(12-30)26-21)11-29-6-7-34-14-22(29)31/h4-5,8,10,12,15H,6-7,11,13-14H2,1-3H3,(H,25,27,32)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436198
PNG
(US10590109, Compound 16)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O3/c1-15(2)26-18-9-20(25-11-17(18)10-24)28-23(34)30(4)21-6-5-16(19(14-32)27-21)12-31-8-7-29(3)13-22(31)33/h5-6,9,11,14-15H,7-8,12-13H2,1-4H3,(H2,25,26,28,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436203
PNG
(US10590109, Compound 21)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CO)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C18H20N6O4/c1-24(17-4-3-12(10-25)15(11-26)22-17)18(27)23-16-7-14(20-5-6-28-2)13(8-19)9-21-16/h3-4,7,9,11,25H,5-6,10H2,1-2H3,(H2,20,21,23,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436206
PNG
(US10590109, Compound 24)
Show SMILES COC[C@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436188
PNG
(US10590109, Compound 6)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2cccc(C=O)n2)ncc1C#N
Show InChI InChI=1S/C17H17N5O3/c1-11(2)25-14-7-15(19-9-12(14)8-18)21-17(24)22(3)16-6-4-5-13(10-23)20-16/h4-7,9-11H,1-3H3,(H,19,21,24)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436193
PNG
(US10590109, Compound 11)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCOCC2=O)c(C=O)n1
Show InChI InChI=1S/C19H17ClN6O4/c1-25(19(29)24-16-6-14(20)13(7-21)8-22-16)17-3-2-12(15(10-27)23-17)9-26-4-5-30-11-18(26)28/h2-3,6,8,10H,4-5,9,11H2,1H3,(H,22,24,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436194
PNG
(US10590109, Compound 12)
Show SMILES COCCOc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H24N6O6/c1-27(22(31)26-19-9-18(34-8-7-32-2)16(10-23)11-24-19)20-4-3-15(17(13-29)25-20)12-28-5-6-33-14-21(28)30/h3-4,9,11,13H,5-8,12,14H2,1-2H3,(H,24,26,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436195
PNG
(US10590109, Compound 13)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H24N6O5/c1-14(2)33-18-8-19(24-10-16(18)9-23)26-22(31)27(3)20-5-4-15(17(12-29)25-20)11-28-6-7-32-13-21(28)30/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H,24,26,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436195
PNG
(US10590109, Compound 13)
Show SMILES CC(C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H24N6O5/c1-14(2)33-18-8-19(24-10-16(18)9-23)26-22(31)27(3)20-5-4-15(17(12-29)25-20)11-28-6-7-32-13-21(28)30/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H,24,26,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436196
PNG
(US10590109, Compound 14)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H26N6O6/c1-15(13-33-3)35-19-8-20(25-10-17(19)9-24)27-23(32)28(2)21-5-4-16(18(12-30)26-21)11-29-6-7-34-14-22(29)31/h4-5,8,10,12,15H,6-7,11,13-14H2,1-3H3,(H,25,27,32)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436205
PNG
(US10590109, Compound 22)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CO)c(C=O)n1
Show InChI InChI=1S/C15H12ClN5O3/c1-21(14-3-2-9(7-22)12(8-23)19-14)15(24)20-13-4-11(16)10(5-17)6-18-13/h2-4,6,8,22H,7H2,1H3,(H,18,20,24)
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436205
PNG
(US10590109, Compound 22)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CO)c(C=O)n1
Show InChI InChI=1S/C15H12ClN5O3/c1-21(14-3-2-9(7-22)12(8-23)19-14)15(24)20-13-4-11(16)10(5-17)6-18-13/h2-4,6,8,22H,7H2,1H3,(H,18,20,24)
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436206
PNG
(US10590109, Compound 24)
Show SMILES COC[C@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m0/s1
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436184
PNG
(US10590109, Compound 3)
Show SMILES CN(C(=O)Nc1ccc(cn1)C#C)c1cccc(C=O)n1
Show InChI InChI=1S/C15H12N4O2/c1-3-11-7-8-13(16-9-11)18-15(21)19(2)14-6-4-5-12(10-20)17-14/h1,4-10H,2H3,(H,16,18,21)
PDB

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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436191
PNG
(US10590109, Compound 9)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCOCC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C22H25N7O5/c1-28(22(32)27-19-9-17(24-5-7-33-2)16(10-23)11-25-19)20-4-3-15(18(13-30)26-20)12-29-6-8-34-14-21(29)31/h3-4,9,11,13H,5-8,12,14H2,1-2H3,(H2,24,25,27,32)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436193
PNG
(US10590109, Compound 11)
Show SMILES CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCOCC2=O)c(C=O)n1
Show InChI InChI=1S/C19H17ClN6O4/c1-25(19(29)24-16-6-14(20)13(7-21)8-22-16)17-3-2-12(15(10-27)23-17)9-26-4-5-30-11-18(26)28/h2-3,6,8,10H,4-5,9,11H2,1H3,(H,22,24,29)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436198
PNG
(US10590109, Compound 16)
Show SMILES CC(C)Nc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C23H28N8O3/c1-15(2)26-18-9-20(25-11-17(18)10-24)28-23(34)30(4)21-6-5-16(19(14-32)27-21)12-31-8-7-29(3)13-22(31)33/h5-6,9,11,14-15H,7-8,12-13H2,1-4H3,(H2,25,26,28,34)
PDB

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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806)


(Homo sapiens (Human))
BDBM436200
PNG
(US10590109, Compound 18 | US10590109, Compound 25)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-16(15-35-4)36-20-9-21(26-11-18(20)10-25)28-24(34)30(3)22-6-5-17(19(14-32)27-22)12-31-8-7-29(2)13-23(31)33/h5-6,9,11,14,16H,7-8,12-13,15H2,1-4H3,(H,26,28,34)/t16-/m1/s1
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Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731)


(Homo sapiens (Human))
BDBM436203
PNG
(US10590109, Compound 21)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CO)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C18H20N6O4/c1-24(17-4-3-12(10-25)15(11-26)22-17)18(27)23-16-7-14(20-5-6-28-2)13(8-19)9-21-16/h3-4,7,9,11,25H,5-6,10H2,1-2H3,(H2,20,21,23,27)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821)


(Homo sapiens (Human))
BDBM436203
PNG
(US10590109, Compound 21)
Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CO)c(C=O)n2)ncc1C#N
Show InChI InChI=1S/C18H20N6O4/c1-24(17-4-3-12(10-25)15(11-26)22-17)18(27)23-16-7-14(20-5-6-28-2)13(8-19)9-21-16/h3-4,7,9,11,25H,5-6,10H2,1-2H3,(H2,20,21,23,27)
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



Nanjing InnoCare Pharma Tech Co., Ltd.

US Patent


Assay Description
FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...


US Patent US10590109 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%