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Patent code US10590114

Compile Data Set for Download or QSAR

Found 215 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384451
PNG
(US10590114, No. 138 | US9932325, Example 137 | US9...)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C(C)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C17H20F3N9/c1-3-21-15-12(17(18,19)20)9-22-16(26-15)25-14-8-13(27-28(14)11-4-5-11)10(2)29-23-6-7-24-29/h6-11H,3-5H2,1-2H3,(H2,21,22,25,26)
PDB

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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384453
PNG
(US10590114, No. 139 | US9932325, Example 139)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)S(C)(=O)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H23F3N6O2S/c1-5-21-14-11(17(18,19)20)9-22-15(24-14)23-13-8-12(16(2,3)29(4,27)28)25-26(13)10-6-7-10/h8-10H,5-7H2,1-4H3,(H2,21,22,23,24)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384462
PNG
(US10590114, No. 148 | US9932325, Example 148)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)COC2)ncc1Br
Show InChI InChI=1S/C16H21BrN6O/c1-3-18-14-11(17)7-19-15(21-14)20-13-6-12(16(2)8-24-9-16)22-23(13)10-4-5-10/h6-7,10H,3-5,8-9H2,1-2H3,(H2,18,19,20,21)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384474
PNG
(US10590114, No. 161 | US9932325, Example 160 | US9...)
Show SMILES COc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N5O3/c1-16(5-6-28-14(16)26)11-7-12(25(24-11)9-3-4-9)22-15-21-8-10(17(18,19)20)13(23-15)27-2/h7-9H,3-6H2,1-2H3,(H,21,22,23)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384477
PNG
(US10590114, No. 163 | US9932325, Example 163)
Show SMILES CNc1nc(Nc2cc(nn2C2CC2)[C@@]23C[C@@H]2COC3=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H17F3N6O2/c1-21-13-10(17(18,19)20)6-22-15(24-13)23-12-4-11(25-26(12)9-2-3-9)16-5-8(16)7-28-14(16)27/h4,6,8-9H,2-3,5,7H2,1H3,(H2,21,22,23,24)/t8-,16-/m1/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384484
PNG
(US10590114, No. 170 | US9932325, Example 170)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)[C@H]2C[C@H]2C(N)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H20F3N7O/c1-2-22-15-11(17(18,19)20)7-23-16(25-15)24-13-6-12(9-5-10(9)14(21)28)26-27(13)8-3-4-8/h6-10H,2-5H2,1H3,(H2,21,28)(H2,22,23,24,25)/t9-,10+/m0/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384496
PNG
(US10590114, No. 182 | US9932325, Example 182)
Show SMILES CCNc1nc(Nc2ccnn2[C@H]2C[C@@H](C2)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H18F3N9/c1-2-20-14-12(16(17,18)19)9-21-15(26-14)25-13-3-4-22-27(13)10-7-11(8-10)28-23-5-6-24-28/h3-6,9-11H,2,7-8H2,1H3,(H2,20,21,25,26)/t10-,11-
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384498
PNG
(US10590114, No. 184 | US9932325, Example 184)
Show SMILES CCNc1nc(Nc2cc(nn2C)[C@@]23C[C@@H]2COC3=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H17F3N6O2/c1-3-20-12-9(16(17,18)19)6-21-14(23-12)22-11-4-10(24-25(11)2)15-5-8(15)7-27-13(15)26/h4,6,8H,3,5,7H2,1-2H3,(H2,20,21,22,23)/t8-,15-/m1/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384500
PNG
(US10590114, No. 187 | US9932325, Example 186 | US9...)
Show SMILES CCNc1nc(Nc2cc(nn2C)C2(C)CCCO2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H21F3N6O/c1-4-20-13-10(16(17,18)19)9-21-14(23-13)22-12-8-11(24-25(12)3)15(2)6-5-7-26-15/h8-9H,4-7H2,1-3H3,(H2,20,21,22,23)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384527
PNG
(US10590114, No. 213 | US9932325, Example 213)
Show SMILES COc1nc(Nc2cn(nc2C2CC2)C2C[C@H]2C#N)ncc1Br
Show InChI InChI=1S/C15H15BrN6O/c1-23-14-10(16)6-18-15(20-14)19-11-7-22(12-4-9(12)5-17)21-13(11)8-2-3-8/h6-9,12H,2-4H2,1H3,(H,18,19,20)/t9-,12?/m0/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM196756
PNG
(US10590114, No. 18 | US9212173, 34 | US9932325, Ex...)
Show SMILES CCNc1nc(Nc2cn(nc2C)C(C)(C)c2ccn(C)n2)ncc1C(F)(F)F
Show InChI InChI=1S/C18H23F3N8/c1-6-22-15-12(18(19,20)21)9-23-16(25-15)24-13-10-29(26-11(13)2)17(3,4)14-7-8-28(5)27-14/h7-10H,6H2,1-5H3,(H2,22,23,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384328
PNG
(US10590114, No. 25 | US9932325, Example 25)
Show SMILES CCNc1nc(Nc2cn(nc2C)C2CCN(C)C2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H20F3N7O/c1-4-20-13-10(16(17,18)19)7-21-15(23-13)22-11-8-26(24-9(11)2)12-5-6-25(3)14(12)27/h7-8,12H,4-6H2,1-3H3,(H2,20,21,22,23)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384347
PNG
(BDBM384370 | US10590114, No. 70 | US9932325, Examp...)
Show SMILES CCNc1nc(Nc2cc(nn2C)C(C)(C)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H20F3N9/c1-5-20-13-10(16(17,18)19)9-21-14(25-13)24-12-8-11(26-27(12)4)15(2,3)28-22-6-7-23-28/h6-9H,5H2,1-4H3,(H2,20,21,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384360
PNG
(US10590114, No. 43 | US9932325, Example 43)
Show SMILES CCNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1Br
Show InChI InChI=1S/C14H18BrN7/c1-5-17-12-10(15)6-18-13(20-12)19-11-7-22(21-9(11)2)14(3,4)8-16/h6-7H,5H2,1-4H3,(H2,17,18,19,20)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384363
PNG
(BDBM384372 | US10590114, No. 59 | US9932325, Examp...)
Show SMILES Cc1nn(cc1Nc1ncc(c(NCC(F)F)n1)C(F)(F)F)C(C)(C)C#N
Show InChI InChI=1S/C15H16F5N7/c1-8-10(6-27(26-8)14(2,3)7-21)24-13-23-4-9(15(18,19)20)12(25-13)22-5-11(16)17/h4,6,11H,5H2,1-3H3,(H2,22,23,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384368
PNG
(US10590114, No. 54B | US9932325, Example 54A | US9...)
Show SMILES CCNc1nc(Nc2cnn3CC(Cc23)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C15H16F3N9/c1-2-19-13-10(15(16,17)18)6-20-14(25-13)24-11-7-23-26-8-9(5-12(11)26)27-21-3-4-22-27/h3-4,6-7,9H,2,5,8H2,1H3,(H2,19,20,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM50448118
PNG
(CHEMBL3122113 | US10590114, No. 80 | US9932325, Ex...)
Show SMILES CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
PDB

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n/an/a<30n/an/an/an/an/an/a



Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384379
PNG
(US10590114, No. 65 | US9932325, Example 65)
Show SMILES COc1nc(Nc2cnn(c2C)C2(C)CCNC2=O)ncc1Br
Show InChI InChI=1S/C14H17BrN6O2/c1-8-10(19-13-17-6-9(15)11(20-13)23-3)7-18-21(8)14(2)4-5-16-12(14)22/h6-7H,4-5H2,1-3H3,(H,16,22)(H,17,19,20)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384404
PNG
(US10590114, No. 102 | US9932325, Example 102 | US9...)
Show SMILES COc1nc(Nc2cn(nc2C)C2(C)CCOC2=O)ncc1Br
Show InChI InChI=1S/C14H16BrN5O3/c1-8-10(17-13-16-6-9(15)11(18-13)22-3)7-20(19-8)14(2)4-5-23-12(14)21/h6-7H,4-5H2,1-3H3,(H,16,17,18)
PDB

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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384417
PNG
(US10590114, No. 120 | US9932325, Example 103 | US9...)
Show SMILES Cc1nn(cc1Nc1ncc(c(n1)C1CC1)C(F)(F)F)C1(C)CCOC1=O
Show InChI InChI=1S/C17H18F3N5O2/c1-9-12(8-25(24-9)16(2)5-6-27-14(16)26)22-15-21-7-11(17(18,19)20)13(23-15)10-3-4-10/h7-8,10H,3-6H2,1-2H3,(H,21,22,23)
PDB

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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384420
PNG
(US10590114, No. 121 | US9932325, Example 106)
Show SMILES CCNc1nc(Nc2cnn(C3C[C@@H](C3)N3CCN(CC(F)F)CC3)c2C)ncc1C(F)(F)F
Show InChI InChI=1S/C21H29F5N8/c1-3-27-19-16(21(24,25)26)10-28-20(31-19)30-17-11-29-34(13(17)2)15-8-14(9-15)33-6-4-32(5-7-33)12-18(22)23/h10-11,14-15,18H,3-9,12H2,1-2H3,(H2,27,28,30,31)/t14-,15?
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384457
PNG
(US10590114, No. 144 | US9932325, Example 143 | US9...)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C18H21F3N6O2/c1-3-22-14-11(18(19,20)21)9-23-16(25-14)24-13-8-12(26-27(13)10-4-5-10)17(2)6-7-29-15(17)28/h8-10H,3-7H2,1-2H3,(H2,22,23,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384468
PNG
(US10590114, No. 154 | US9932325, Example 154)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)N2CCCS2(=O)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H20F3N7O2S/c1-2-20-14-11(16(17,18)19)9-21-15(23-14)22-12-8-13(24-26(12)10-4-5-10)25-6-3-7-29(25,27)28/h8-10H,2-7H2,1H3,(H2,20,21,22,23)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384469
PNG
(US10590114, No. 156 | US9932325, Example 155 | US9...)
Show SMILES CNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N6O2/c1-16(5-6-28-14(16)27)11-7-12(26(25-11)9-3-4-9)23-15-22-8-10(17(18,19)20)13(21-2)24-15/h7-9H,3-6H2,1-2H3,(H2,21,22,23,24)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384469
PNG
(US10590114, No. 156 | US9932325, Example 155 | US9...)
Show SMILES CNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N6O2/c1-16(5-6-28-14(16)27)11-7-12(26(25-11)9-3-4-9)23-15-22-8-10(17(18,19)20)13(21-2)24-15/h7-9H,3-6H2,1-2H3,(H2,21,22,23,24)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384472
PNG
(US10590114, No. 158 | US9932325, Example 158)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)N2CCCC2=O)ncc1Br
Show InChI InChI=1S/C16H20BrN7O/c1-2-18-15-11(17)9-19-16(21-15)20-12-8-13(22-24(12)10-5-6-10)23-7-3-4-14(23)25/h8-10H,2-7H2,1H3,(H2,18,19,20,21)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384483
PNG
(US10590114, No. 169 | US9932325, Example 169)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)[C@H]2C[C@H]2C(=O)OCC)ncc1C(F)(F)F
Show InChI InChI=1S/C19H23F3N6O2/c1-3-23-16-13(19(20,21)22)9-24-18(26-16)25-15-8-14(27-28(15)10-5-6-10)11-7-12(11)17(29)30-4-2/h8-12H,3-7H2,1-2H3,(H2,23,24,25,26)/t11-,12+/m0/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM436382
PNG
(US10590114, No. 177 | US10590114, No. 178)
Show SMILES CNc1nc(Nc2cc(nn2C)C2(C)CCn3ccnc23)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N8/c1-16(4-6-28-7-5-22-14(16)28)11-8-12(27(3)26-11)24-15-23-9-10(17(18,19)20)13(21-2)25-15/h5,7-9H,4,6H2,1-3H3,(H2,21,23,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384499
PNG
(US10590114, No. 185 | US9932325, Example 185)
Show SMILES CCNc1nc(Nc2cc(nn2C)[C@]23C[C@H]2COC3=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H17F3N6O2/c1-3-20-12-9(16(17,18)19)6-21-14(23-12)22-11-4-10(24-25(11)2)15-5-8(15)7-27-13(15)26/h4,6,8H,3,5,7H2,1-2H3,(H2,20,21,22,23)/t8-,15-/m0/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384516
PNG
(US10590114, No. 203 | US9932325, Example 202 | US9...)
Show SMILES CCN1CCC(F)(F)C(C1)n1ncc(Nc2ncc(c(NC)n2)C(F)(F)F)c1Cl
Show InChI InChI=1S/C16H19ClF5N7/c1-3-28-5-4-15(18,19)11(8-28)29-12(17)10(7-25-29)26-14-24-6-9(16(20,21)22)13(23-2)27-14/h6-7,11H,3-5,8H2,1-2H3,(H2,23,24,26,27)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384521
PNG
(US10590114, No. 207 | US9932325, Example 207)
Show SMILES CCNc1nc(Nc2cn(nc2Cl)C2C[C@H]2C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H13ClF3N7/c1-2-20-12-8(14(16,17)18)5-21-13(23-12)22-9-6-25(24-11(9)15)10-3-7(10)4-19/h5-7,10H,2-3H2,1H3,(H2,20,21,22,23)/t7-,10?/m0/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384523
PNG
(US10590114, No. 209 | US9932325, Example 209)
Show SMILES CNc1nc(Nc2cn(nc2C2CC2)C2C[C@H]2C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C16H16F3N7/c1-21-14-10(16(17,18)19)6-22-15(24-14)23-11-7-26(12-4-9(12)5-20)25-13(11)8-2-3-8/h6-9,12H,2-4H2,1H3,(H2,21,22,23,24)/t9-,12?/m0/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384312
PNG
(US10590114, No. 16 | US9932325, Example 16)
Show SMILES CNc1nc(Nc2cnn3CC4(COC4)Cc23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H15F3N6O/c1-18-11-8(14(15,16)17)3-19-12(22-11)21-9-4-20-23-5-13(2-10(9)23)6-24-7-13/h3-4H,2,5-7H2,1H3,(H2,18,19,21,22)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384314
PNG
(US10590114, No. 17 | US9932325, Example 17)
Show SMILES CNc1nc(Nc2cnn3CC4(CC4)COc23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H15F3N6O/c1-18-10-8(14(15,16)17)4-19-12(22-10)21-9-5-20-23-6-13(2-3-13)7-24-11(9)23/h4-5H,2-3,6-7H2,1H3,(H2,18,19,21,22)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384334
PNG
(US10590114, No. 29 | US9932325, Example 28 | US993...)
Show SMILES CNc1nc(Nc2cnn(C3CN(CCC3(F)F)C3COC3)c2Cl)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19ClF5N7O/c1-24-14-10(17(21,22)23)4-25-15(28-14)27-11-5-26-30(13(11)18)12-6-29(9-7-31-8-9)3-2-16(12,19)20/h4-5,9,12H,2-3,6-8H2,1H3,(H2,24,25,27,28)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384356
PNG
(US10590114, No. 39A | US9932325, Example 39A)
Show SMILES Cc1nn(cc1Nc1ncc(c(N[C@H]2C[C@H]2F)n1)C(F)(F)F)C(C)(C)C#N
Show InChI InChI=1S/C16H17F4N7/c1-8-12(6-27(26-8)15(2,3)7-21)24-14-22-5-9(16(18,19)20)13(25-14)23-11-4-10(11)17/h5-6,10-11H,4H2,1-3H3,(H2,22,23,24,25)/t10-,11+/m1/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384366
PNG
(US10590114, No. 52B | US9932325, Example 52A | US9...)
Show SMILES CCNc1nc(Nc2cnn3CC(Cc23)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H14F3N7/c1-2-19-12-9(14(15,16)17)5-20-13(23-12)22-10-6-21-24-7-8(4-18)3-11(10)24/h5-6,8H,2-3,7H2,1H3,(H2,19,20,22,23)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384347
PNG
(BDBM384370 | US10590114, No. 70 | US9932325, Examp...)
Show SMILES CCNc1nc(Nc2cc(nn2C)C(C)(C)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H20F3N9/c1-5-20-13-10(16(17,18)19)9-21-14(25-13)24-12-8-11(26-27(12)4)15(2,3)28-22-6-7-23-28/h6-9H,5H2,1-4H3,(H2,20,21,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384393
PNG
(US10590114, No. 79 | US9932325, Example 79)
Show SMILES Cn1nc(cc1Nc1ncc(Br)c(NC2CC2)n1)C(C)(C)n1nccn1
Show InChI InChI=1S/C16H20BrN9/c1-16(2,26-19-6-7-20-26)12-8-13(25(3)24-12)22-15-18-9-11(17)14(23-15)21-10-4-5-10/h6-10H,4-5H2,1-3H3,(H2,18,21,22,23)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384395
PNG
(US10590114, No. 81 | US9932325, Example 81)
Show SMILES Cn1nc(cc1Nc1ncc(Br)c(OC2CC2)n1)C(C)(C)n1nccn1
Show InChI InChI=1S/C16H19BrN8O/c1-16(2,25-19-6-7-20-25)12-8-13(24(3)23-12)21-15-18-9-11(17)14(22-15)26-10-4-5-10/h6-10H,4-5H2,1-3H3,(H,18,21,22)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384405
PNG
(US10590114, No. 108 | US9932325, Example 104 | US9...)
Show SMILES CCNc1nc(Nc2cn(nc2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C18H21F3N6O2/c1-3-22-14-11(18(19,20)21)8-23-16(25-14)24-12-9-27(26-13(12)10-4-5-10)17(2)6-7-29-15(17)28/h8-10H,3-7H2,1-2H3,(H2,22,23,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384407
PNG
(US10590114, No. 93 | US9932325, Example 93)
Show SMILES CCNc1nc(Nc2cn(nc2C2CC2)C(C)(C)C#N)ncc1Br
Show InChI InChI=1S/C16H20BrN7/c1-4-19-14-11(17)7-20-15(22-14)21-12-8-24(16(2,3)9-18)23-13(12)10-5-6-10/h7-8,10H,4-6H2,1-3H3,(H2,19,20,21,22)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384408
PNG
(US10590114, No. 94 | US9932325, Example 94)
Show SMILES CCNc1nc(Nc2cn(Cc3ccon3)nc2C2CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N7O/c1-2-21-15-12(17(18,19)20)7-22-16(24-15)23-13-9-27(8-11-5-6-28-26-11)25-14(13)10-3-4-10/h5-7,9-10H,2-4,8H2,1H3,(H2,21,22,23,24)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384413
PNG
(US10590114, No. 123 | US9932325, Example 123 | US9...)
Show SMILES CNc1nc(Nc2cn(nc2Cl)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C14H14ClF3N6O2/c1-13(3-4-26-11(13)25)24-6-8(9(15)23-24)21-12-20-5-7(14(16,17)18)10(19-2)22-12/h5-6H,3-4H2,1-2H3,(H2,19,20,21,22)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384414
PNG
(US10590114, No. 125 | US9932325, Example 100 | US9...)
Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H19F3N6O2/c1-4-20-12-10(16(17,18)19)7-21-14(23-12)22-11-8-25(24-9(11)2)15(3)5-6-27-13(15)26/h7-8H,4-6H2,1-3H3,(H2,20,21,22,23)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384421
PNG
(US10590114, No. 107 | US9932325, Example 107)
Show SMILES CCNc1nc(Nc2cn(nc2C2CC2)C2C[C@@H]2C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N7/c1-2-22-15-11(17(18,19)20)7-23-16(25-15)24-12-8-27(13-5-10(13)6-21)26-14(12)9-3-4-9/h7-10,13H,2-5H2,1H3,(H2,22,23,24,25)/t10-,13?/m1/s1
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384405
PNG
(US10590114, No. 108 | US9932325, Example 104 | US9...)
Show SMILES CCNc1nc(Nc2cn(nc2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C18H21F3N6O2/c1-3-22-14-11(18(19,20)21)8-23-16(25-14)24-12-9-27(26-13(12)10-4-5-10)17(2)6-7-29-15(17)28/h8-10H,3-7H2,1-2H3,(H2,22,23,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384432
PNG
(US10590114, No. 118 | US9932325, Example 118)
Show SMILES CCNc1nc(Nc2cn(nc2C2CC2)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C17H20F3N7/c1-4-22-14-11(17(18,19)20)7-23-15(25-14)24-12-8-27(16(2,3)9-21)26-13(12)10-5-6-10/h7-8,10H,4-6H2,1-3H3,(H2,22,23,24,25)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384433
PNG
(US10590114, No. 124 | US9932325, Example 119 | US9...)
Show SMILES CNc1nc(Nc2cn(nc2C)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C15H17F3N6O2/c1-8-10(7-24(23-8)14(2)4-5-26-12(14)25)21-13-20-6-9(15(16,17)18)11(19-3)22-13/h6-7H,4-5H2,1-3H3,(H2,19,20,21,22)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM384417
PNG
(US10590114, No. 120 | US9932325, Example 103 | US9...)
Show SMILES Cc1nn(cc1Nc1ncc(c(n1)C1CC1)C(F)(F)F)C1(C)CCOC1=O
Show InChI InChI=1S/C17H18F3N5O2/c1-9-12(8-25(24-9)16(2)5-6-27-14(16)26)22-15-21-7-11(17(18,19)20)13(23-15)10-3-4-10/h7-8,10H,3-6H2,1-2H3,(H,21,22,23)
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Denali Therapautics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US10590114 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%