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Patent code US10596184

Compile Data Set for Download or QSAR
Found 158 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281483
PNG
(US10022387, Example 8 | US10596184, Example 8 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccc(Br)cc2[nH]1
Show InChI InChI=1S/C20H13BrN4O2/c1-26-14-6-12(9-22-10-14)11-2-4-16-18(7-11)27-20(25-16)19-23-15-5-3-13(21)8-17(15)24-19/h2-10H,1H3,(H,23,24)
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n/an/a>100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM437712
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2-yl)benzo[d]oxazol...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2n1
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281493
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2- yl)benzo[d]oxazo...)
Show SMILES Fc1cccc(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H16FN5O3S/c26-17-4-3-5-19(12-17)35(32,33)31-18-10-16(13-27-14-18)15-8-9-22-23(11-15)34-25(30-22)24-28-20-6-1-2-7-21(20)29-24/h1-14,31H,(H,28,29)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281500
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16ClN5O3S/c1-2-31(28,29)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281511
PNG
(US10022387, Example 37 | US10596184, Example 37 | ...)
Show SMILES CN(C)S(=O)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N5O3S/c1-26(2)30(27,28)15-9-14(11-22-12-15)13-7-8-18-19(10-13)29-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281526
PNG
(US10022387, Example 52 | US10596184, Example 52 | ...)
Show SMILES CCS(=O)(=O)n1ncc2ccc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H17N5O3S/c1-2-32(29,30)28-20-11-14(7-8-16(20)13-24-28)15-9-10-19-21(12-15)31-23(27-19)22-25-17-5-3-4-6-18(17)26-22/h3-13H,2H2,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281526
PNG
(US10022387, Example 52 | US10596184, Example 52 | ...)
Show SMILES CCS(=O)(=O)n1ncc2ccc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H17N5O3S/c1-2-32(29,30)28-20-11-14(7-8-16(20)13-24-28)15-9-10-19-21(12-15)31-23(27-19)22-25-17-5-3-4-6-18(17)26-22/h3-13H,2H2,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281533
PNG
(US10022387, Example 59 | US10596184, Example 59 | ...)
Show SMILES CCNS(=O)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N5O3S/c1-2-23-30(27,28)15-9-14(11-22-12-15)13-7-8-18-19(10-13)29-21(26-18)20-24-16-5-3-4-6-17(16)25-20/h3-12,23H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281541
PNG
(US10022387, Example 67 | US10596184, Example 67 | ...)
Show SMILES Cc1nc([nH]c1C)-c1nc2ccc(cc2o1)-c1cncc(c1)C(O)C(F)(F)F
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281550
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)CC(F)(F)F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H16F3N5O3S/c1-12-18(30-34(31,32)11-22(23,24)25)8-14(10-26-12)13-6-7-17-19(9-13)33-21(29-17)20-27-15-4-2-3-5-16(15)28-20/h2-10,30H,11H2,1H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281551
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES FC(F)(F)CS(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H14F3N5O3S/c22-21(23,24)11-33(30,31)29-14-7-13(9-25-10-14)12-5-6-17-18(8-12)32-20(28-17)19-26-15-3-1-2-4-16(15)27-19/h1-10,29H,11H2,(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281553
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1OC)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H19N5O4S/c1-3-32(28,29)27-18-10-14(12-23-21(18)30-2)13-8-9-17-19(11-13)31-22(26-17)20-24-15-6-4-5-7-16(15)25-20/h4-12,27H,3H2,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281488
PNG
(US10022387, Example 14 | US10596184, Example 14 | ...)
Show SMILES Oc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C19H12N4O2/c24-13-7-12(9-20-10-13)11-5-6-16-17(8-11)25-19(23-16)18-21-14-3-1-2-4-15(14)22-18/h1-10,24H,(H,21,22)
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US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281492
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2- yl)benzo[d]oxazo...)
Show SMILES CCS(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N5O3S/c1-2-30(27,28)26-15-9-14(11-22-12-15)13-7-8-18-19(10-13)29-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12,26H,2H2,1H3,(H,23,24)
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US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281499
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1C)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H19N5O3S/c1-3-31(28,29)27-19-10-15(12-23-13(19)2)14-8-9-18-20(11-14)30-22(26-18)21-24-16-6-4-5-7-17(16)25-21/h4-12,27H,3H2,1-2H3,(H,24,25)
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US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281523
PNG
(US10022387, Example 49 | US10596184, Example 49 | ...)
Show SMILES c1n[nH]c2ccc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H13N5O/c1-2-4-17-16(3-1)23-20(24-17)21-25-18-8-6-13(10-19(18)27-21)12-5-7-15-14(9-12)11-22-26-15/h1-11H,(H,22,26)(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281524
PNG
(US10022387, Example 50 | US10596184, Example 50 | ...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H15N5O/c1-12-15-10-13(6-8-16(15)27-26-12)14-7-9-19-20(11-14)28-22(25-19)21-23-17-4-2-3-5-18(17)24-21/h2-11H,1H3,(H,23,24)(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281532
PNG
(US10022387, Example 58 | US10596184, Example 58 | ...)
Show SMILES OC1CCN(C1)S(=O)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281540
PNG
(US10022387, Example 66 | US10596184, Example 66 | ...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1OC)-c1ccc2nc(oc2c1)-c1nc2CCCCc2[nH]1
Show InChI InChI=1S/C22H23N5O4S/c1-3-32(28,29)27-18-10-14(12-23-21(18)30-2)13-8-9-17-19(11-13)31-22(26-17)20-24-15-6-4-5-7-16(15)25-20/h8-12,27H,3-7H2,1-2H3,(H,24,25)
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n/an/a<250n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281541
PNG
(US10022387, Example 67 | US10596184, Example 67 | ...)
Show SMILES Cc1nc([nH]c1C)-c1nc2ccc(cc2o1)-c1cncc(c1)C(O)C(F)(F)F
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM294402
PNG
(2-(1H-Benzo[d]imidazol- 2-yl)-6-(5-(dimethyl- phos...)
Show SMILES CP(C)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N4O2P/c1-28(2,26)15-9-14(11-22-12-15)13-7-8-18-19(10-13)27-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281549
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES Fc1ncc(cc1NS(=O)(=O)CC(F)(F)F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H13F4N5O3S/c22-18-16(30-34(31,32)10-21(23,24)25)7-12(9-26-18)11-5-6-15-17(8-11)33-20(29-15)19-27-13-3-1-2-4-14(13)28-19/h1-9,30H,10H2,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281496
PNG
(N'-{5-[2-(1H- Benzimidazol-2- yl)-1,3- benzoxazol-...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H20N6O3S/c1-13-19(27-32(29,30)28(2)3)10-15(12-23-13)14-8-9-18-20(11-14)31-22(26-18)21-24-16-6-4-5-7-17(16)25-21/h4-12,27H,1-3H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281502
PNG
(N-(5-(2-(1H- Benzo[d]imdiazol- 2 - yl)benzo[d]oxaz...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H18FN5O3S/c1-15-23(32-36(33,34)19-9-7-18(27)8-10-19)12-17(14-28-15)16-6-11-22-24(13-16)35-26(31-22)25-29-20-4-2-3-5-21(20)30-25/h2-14,32H,1H3,(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281506
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2- yl)benzo[d]oxazo...)
Show SMILES CN1CCN(CC1)S(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H22FN7O3S/c1-31-8-10-32(11-9-31)36(33,34)30-20-12-16(14-26-22(20)25)15-6-7-19-21(13-15)35-24(29-19)23-27-17-4-2-3-5-18(17)28-23/h2-7,12-14,30H,8-11H2,1H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281513
PNG
(US10022387, Example 39 | US10596184, Example 39 | ...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C21H14FN5O3S/c22-15-2-4-17(5-3-15)31(28,29)27-16-9-14(11-23-12-16)13-1-6-18-19(10-13)30-21(26-18)20-24-7-8-25-20/h1-12,27H,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281524
PNG
(US10022387, Example 50 | US10596184, Example 50 | ...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H15N5O/c1-12-15-10-13(6-8-16(15)27-26-12)14-7-9-19-20(11-14)28-22(25-19)21-23-17-4-2-3-5-18(17)24-21/h2-11H,1H3,(H,23,24)(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281539
PNG
(US10022387, Example 65 | US10596184, Example 65 | ...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1OC)-c1ccc2nc(oc2c1)-c1nc(C)c(C)[nH]1
Show InChI InChI=1S/C20H21N5O4S/c1-5-30(26,27)25-16-8-14(10-21-19(16)28-4)13-6-7-15-17(9-13)29-20(24-15)18-22-11(2)12(3)23-18/h6-10,25H,5H2,1-4H3,(H,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281554
PNG
(US10022387, Example 80 | US10596184, Example 80 | ...)
Show SMILES CCS(=O)(=O)Nc1cc(cc(F)c1OC)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H19FN4O4S/c1-3-33(29,30)28-19-11-14(10-15(24)21(19)31-2)13-8-9-18-20(12-13)32-23(27-18)22-25-16-6-4-5-7-17(16)26-22/h4-12,28H,3H2,1-2H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281485
PNG
(US10022387, Example 11 | US10596184, Example 11 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2cc(C)ccc2[nH]1
Show InChI InChI=1S/C21H16N4O2/c1-12-3-5-16-18(7-12)24-20(23-16)21-25-17-6-4-13(9-19(17)27-21)14-8-15(26-2)11-22-10-14/h3-11H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281490
PNG
(US10022387, Example 16 | US10596184, Example 16 | ...)
Show SMILES FC(F)Oc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H12F2N4O2/c21-20(22)27-13-7-12(9-23-10-13)11-5-6-16-17(8-11)28-19(26-16)18-24-14-3-1-2-4-15(14)25-18/h1-10,20H,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM437712
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2-yl)benzo[d]oxazol...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2n1
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281496
PNG
(N'-{5-[2-(1H- Benzimidazol-2- yl)-1,3- benzoxazol-...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H20N6O3S/c1-13-19(27-32(29,30)28(2)3)10-15(12-23-13)14-8-9-18-20(11-14)31-22(26-18)21-24-16-6-4-5-7-17(16)25-21/h4-12,27H,1-3H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281502
PNG
(N-(5-(2-(1H- Benzo[d]imdiazol- 2 - yl)benzo[d]oxaz...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H18FN5O3S/c1-15-23(32-36(33,34)19-9-7-18(27)8-10-19)12-17(14-28-15)16-6-11-22-24(13-16)35-26(31-22)25-29-20-4-2-3-5-21(20)30-25/h2-14,32H,1H3,(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281504
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H15F2N5O3S/c26-16-6-8-17(9-7-16)36(33,34)32-21-11-15(13-28-23(21)27)14-5-10-20-22(12-14)35-25(31-20)24-29-18-3-1-2-4-19(18)30-24/h1-13,32H,(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281518
PNG
(6-(5- Methoxypyridin- 3-yl)-2-(2- phenyl-1H- imida...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C22H16N4O2/c1-27-17-9-16(11-23-12-17)15-7-8-18-20(10-15)28-22(26-18)19-13-24-21(25-19)14-5-3-2-4-6-14/h2-13H,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281538
PNG
(US10022387, Example 64 | US10596184, Example 64 | ...)
Show SMILES CCCc1nc([nH]c1C)-c1nc2ccc(cc2o1)-c1cncc(NS(=O)(=O)CC)c1
Show InChI InChI=1S/C21H23N5O3S/c1-4-6-17-13(3)23-20(24-17)21-25-18-8-7-14(10-19(18)29-21)15-9-16(12-22-11-15)26-30(27,28)5-2/h7-12,26H,4-6H2,1-3H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281542
PNG
(US10022387, Example 68 | US10596184, Example 68 | ...)
Show SMILES OC(c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2CCCCc2[nH]1)C(F)(F)F
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM294335
PNG
(2-(1H-Benzo[d]imidazol-2-yl)-6-(5-methoxypyridin-3...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H14N4O2/c1-25-14-8-13(10-21-11-14)12-6-7-17-18(9-12)26-20(24-17)19-22-15-4-2-3-5-16(15)23-19/h2-11H,1H3,(H,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM437727
PNG
(2-(1H-Benzimidazol-2-yl)-6-(1-ethyl-1H-indazol-6-y...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H18FN5O3S/c1-15-6-9-18(10-7-15)36(33,34)32-22-12-17(14-28-24(22)27)16-8-11-21-23(13-16)35-26(31-21)25-29-19-4-2-3-5-20(19)30-25/h2-14,32H,1H3,(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281506
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2- yl)benzo[d]oxazo...)
Show SMILES CN1CCN(CC1)S(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H22FN7O3S/c1-31-8-10-32(11-9-31)36(33,34)30-20-12-16(14-26-22(20)25)15-6-7-19-21(13-15)35-24(29-19)23-27-17-4-2-3-5-18(17)28-23/h2-7,12-14,30H,8-11H2,1H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281508
PNG
(US10022387, Example 34 | US10596184, Example 34 | ...)
Show SMILES CN(C)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N5O/c1-26(2)15-9-14(11-22-12-15)13-7-8-18-19(10-13)27-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281512
PNG
(US10022387, Example 38 | US10596184, Example 38 | ...)
Show SMILES O=S(=O)(N1CCOCC1)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H19N5O4S/c29-33(30,28-7-9-31-10-8-28)17-11-16(13-24-14-17)15-5-6-20-21(12-15)32-23(27-20)22-25-18-3-1-2-4-19(18)26-22/h1-6,11-14H,7-10H2,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281513
PNG
(US10022387, Example 39 | US10596184, Example 39 | ...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C21H14FN5O3S/c22-15-2-4-17(5-3-15)31(28,29)27-16-9-14(11-23-12-16)13-1-6-18-19(10-13)30-21(26-18)20-24-7-8-25-20/h1-12,27H,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281525
PNG
(US10022387, Example 51 | US10596184, Example 51 | ...)
Show SMILES Fc1ccc(cc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H11F2N3O/c21-13-7-5-11(9-14(13)22)12-6-8-17-18(10-12)26-20(25-17)19-23-15-3-1-2-4-16(15)24-19/h1-10H,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281537
PNG
(US10022387, Example 63 | US10596184, Example 63 | ...)
Show SMILES CCS(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc(C)c(C)[nH]1
Show InChI InChI=1S/C19H19N5O3S/c1-4-28(25,26)24-15-7-14(9-20-10-15)13-5-6-16-17(8-13)27-19(23-16)18-21-11(2)12(3)22-18/h5-10,24H,4H2,1-3H3,(H,21,22)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281550
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)CC(F)(F)F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H16F3N5O3S/c1-12-18(30-34(31,32)11-22(23,24)25)8-14(10-26-12)13-6-7-17-19(9-13)33-21(29-17)20-27-15-4-2-3-5-16(15)28-20/h2-10,30H,11H2,1H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281486
PNG
(US10022387, Example 12 | US10596184, Example 12 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2c(C)cccc2[nH]1
Show InChI InChI=1S/C21H16N4O2/c1-12-4-3-5-17-19(12)25-20(23-17)21-24-16-7-6-13(9-18(16)27-21)14-8-15(26-2)11-22-10-14/h3-11H,1-2H3,(H,23,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281493
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2- yl)benzo[d]oxazo...)
Show SMILES Fc1cccc(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H16FN5O3S/c26-17-4-3-5-19(12-17)35(32,33)31-18-10-16(13-27-14-18)15-8-9-22-23(11-15)34-25(30-22)24-28-20-6-1-2-7-21(20)29-24/h1-14,31H,(H,28,29)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM294350
PNG
(N-(5-(2-(1H- Benzo[d]imidazol-2- yl)benzo[d]oxazol...)
Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1)N1CCCCC1
Show InChI InChI=1S/C24H22N6O3S/c31-34(32,30-10-4-1-5-11-30)29-18-12-17(14-25-15-18)16-8-9-21-22(13-16)33-24(28-21)23-26-19-6-2-3-7-20(19)27-23/h2-3,6-9,12-15,29H,1,4-5,10-11H2,(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281495
PNG
(N'-{5-[2-(1H- Benzimidazol-2- yl)-1,3- benzoxazol-...)
Show SMILES CN(C)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H18N6O3S/c1-27(2)31(28,29)26-15-9-14(11-22-12-15)13-7-8-18-19(10-13)30-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12,26H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281501
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16FN5O3S/c1-2-31(28,29)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281510
PNG
(US10022387, Example 36 | US10596184, Example 36 | ...)
Show SMILES CS(=O)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H14N4O3S/c1-28(25,26)14-8-13(10-21-11-14)12-6-7-17-18(9-12)27-20(24-17)19-22-15-4-2-3-5-16(15)23-19/h2-11H,1H3,(H,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281514
PNG
(N-(5-(2-(1H- Imidazol-2- yl)benzo[d]oxazol- 6-yl)p...)
Show SMILES CCS(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C17H15N5O3S/c1-2-26(23,24)22-13-7-12(9-18-10-13)11-3-4-14-15(8-11)25-17(21-14)16-19-5-6-20-16/h3-10,22H,2H2,1H3,(H,19,20)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281534
PNG
(US10022387, Example 60 | US10596184, Example 60 | ...)
Show SMILES CCS(=O)(=O)Nc1cc(ccc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H17FN4O3S/c1-2-31(28,29)27-19-11-13(7-9-15(19)23)14-8-10-18-20(12-14)30-22(26-18)21-24-16-5-3-4-6-17(16)25-21/h3-12,27H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281553
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1OC)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H19N5O4S/c1-3-32(28,29)27-18-10-14(12-23-21(18)30-2)13-8-9-17-19(11-13)31-22(26-17)20-24-15-6-4-5-7-16(15)25-20/h4-12,27H,3H2,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281499
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1C)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H19N5O3S/c1-3-31(28,29)27-19-10-15(12-23-13(19)2)14-8-9-18-20(11-14)30-22(26-18)21-24-16-6-4-5-7-17(16)25-21/h4-12,27H,3H2,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281509
PNG
(US10022387, Example 35 | US10596184, Example 35 | ...)
Show SMILES N#Cc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H11N5O/c21-9-12-7-14(11-22-10-12)13-5-6-17-18(8-13)26-20(25-17)19-23-15-3-1-2-4-16(15)24-19/h1-8,10-11H,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281515
PNG
(N'-{5-[2-(1H- Imidazol-2-yl)-1,3- benzoxazol-6- yl...)
Show SMILES CN(C)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C17H16N6O3S/c1-23(2)27(24,25)22-13-7-12(9-18-10-13)11-3-4-14-15(8-11)26-17(21-14)16-19-5-6-20-16/h3-10,22H,1-2H3,(H,19,20)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281522
PNG
(US10022387, Example 48 | US10596184, Example 48 | ...)
Show SMILES C(c1ccccc1)n1cc(cn1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H17N5O/c1-2-6-16(7-3-1)14-29-15-18(13-25-29)17-10-11-21-22(12-17)30-24(28-21)23-26-19-8-4-5-9-20(19)27-23/h1-13,15H,14H2,(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM437740
PNG
(US10596184, Example 54)
Show SMILES CCn1ncc2ccc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H17N5O/c1-2-28-20-11-14(7-8-16(20)13-24-28)15-9-10-19-21(12-15)29-23(27-19)22-25-17-5-3-4-6-18(17)26-22/h3-13H,2H2,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281530
PNG
(US10022387, Example 56 | US10596184, Example 56 | ...)
Show SMILES Nc1ncc(cc1C(F)(F)F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)12-7-11(9-25-17(12)24)10-5-6-15-16(8-10)29-19(28-15)18-26-13-3-1-2-4-14(13)27-18/h1-9H,(H2,24,25)(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281531
PNG
(US10022387, Example 57 | US10596184, Example 57 | ...)
Show SMILES CCn1ncc2ncc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H16N6O/c1-2-28-19-9-14(11-23-18(19)12-24-28)13-7-8-17-20(10-13)29-22(27-17)21-25-15-5-3-4-6-16(15)26-21/h3-12H,2H2,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281535
PNG
(US10022387, Example 61 | US10596184, Example 61 | ...)
Show SMILES OC(c1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1)C(F)(F)F
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281538
PNG
(US10022387, Example 64 | US10596184, Example 64 | ...)
Show SMILES CCCc1nc([nH]c1C)-c1nc2ccc(cc2o1)-c1cncc(NS(=O)(=O)CC)c1
Show InChI InChI=1S/C21H23N5O3S/c1-4-6-17-13(3)23-20(24-17)21-25-18-8-7-14(10-19(18)29-21)15-9-16(12-22-11-15)26-30(27,28)5-2/h7-12,26H,4-6H2,1-3H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM294399
PNG
(2-(1H-Benzo[d]imidazol- 2-yl)-6-(6-fluoro- 5-metho...)
Show SMILES COc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H13FN4O2/c1-26-17-9-12(10-22-18(17)21)11-6-7-15-16(8-11)27-20(25-15)19-23-13-4-2-3-5-14(13)24-19/h2-10H,1H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281550
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)CC(F)(F)F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H16F3N5O3S/c1-12-18(30-34(31,32)11-22(23,24)25)8-14(10-26-12)13-6-7-17-19(9-13)33-21(29-17)20-27-15-4-2-3-5-16(15)28-20/h2-10,30H,11H2,1H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281479
PNG
(US10022387, Example 4 | US10022387, Example 5 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C21H15N3O2/c1-25-16-8-15(11-22-12-16)13-6-7-18-20(10-13)26-21(24-18)19-9-14-4-2-3-5-17(14)23-19/h2-12,23H,1H3
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281497
PNG
(N'-{5-[2-(1H- Benzimidazol-2- yl)-1,3- benzoxazol-...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17FN6O3S/c1-28(2)32(29,30)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)31-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281497
PNG
(N'-{5-[2-(1H- Benzimidazol-2- yl)-1,3- benzoxazol-...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17FN6O3S/c1-28(2)32(29,30)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)31-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281498
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CC(C)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H19N5O3S/c1-13(2)31(28,29)27-16-9-15(11-23-12-16)14-7-8-19-20(10-14)30-22(26-19)21-24-17-5-3-4-6-18(17)25-21/h3-13,27H,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281503
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2- yl)benzo[d]oxazo...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H15ClFN5O3S/c26-23-21(32-36(33,34)17-8-6-16(27)7-9-17)11-15(13-28-23)14-5-10-20-22(12-14)35-25(31-20)24-29-18-3-1-2-4-19(18)30-24/h1-13,32H,(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281503
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2- yl)benzo[d]oxazo...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H15ClFN5O3S/c26-23-21(32-36(33,34)17-8-6-16(27)7-9-17)11-15(13-28-23)14-5-10-20-22(12-14)35-25(31-20)24-29-18-3-1-2-4-19(18)30-24/h1-13,32H,(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281504
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C25H15F2N5O3S/c26-16-6-8-17(9-7-16)36(33,34)32-21-11-15(13-28-23(21)27)14-5-10-20-22(12-14)35-25(31-20)24-29-18-3-1-2-4-19(18)30-24/h1-13,32H,(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM437727
PNG
(2-(1H-Benzimidazol-2-yl)-6-(1-ethyl-1H-indazol-6-y...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H18FN5O3S/c1-15-6-9-18(10-7-15)36(33,34)32-22-12-17(14-28-24(22)27)16-8-11-21-23(13-16)35-26(31-21)25-29-19-4-2-3-5-20(19)30-25/h2-14,32H,1H3,(H,29,30)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281527
PNG
(US10022387, Example 53 | US10022387, Example 54 | ...)
Show SMILES CCn1cc2ccc(cc2n1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H17N5O/c1-2-28-13-16-8-7-14(11-20(16)27-28)15-9-10-19-21(12-15)29-23(26-19)22-24-17-5-3-4-6-18(17)25-22/h3-13H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281535
PNG
(US10022387, Example 61 | US10596184, Example 61 | ...)
Show SMILES OC(c1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1)C(F)(F)F
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281539
PNG
(US10022387, Example 65 | US10596184, Example 65 | ...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1OC)-c1ccc2nc(oc2c1)-c1nc(C)c(C)[nH]1
Show InChI InChI=1S/C20H21N5O4S/c1-5-30(26,27)25-16-8-14(10-21-19(16)28-4)13-6-7-15-17(9-13)29-20(24-15)18-22-11(2)12(3)23-18/h6-10,25H,5H2,1-4H3,(H,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281540
PNG
(US10022387, Example 66 | US10596184, Example 66 | ...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1OC)-c1ccc2nc(oc2c1)-c1nc2CCCCc2[nH]1
Show InChI InChI=1S/C22H23N5O4S/c1-3-32(28,29)27-18-10-14(12-23-21(18)30-2)13-8-9-17-19(11-13)31-22(26-17)20-24-15-6-4-5-7-16(15)25-20/h8-12,27H,3-7H2,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281542
PNG
(US10022387, Example 68 | US10596184, Example 68 | ...)
Show SMILES OC(c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2CCCCc2[nH]1)C(F)(F)F
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM294402
PNG
(2-(1H-Benzo[d]imidazol- 2-yl)-6-(5-(dimethyl- phos...)
Show SMILES CP(C)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N4O2P/c1-28(2,26)15-9-14(11-22-12-15)13-7-8-18-19(10-13)27-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281550
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)CC(F)(F)F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H16F3N5O3S/c1-12-18(30-34(31,32)11-22(23,24)25)8-14(10-26-12)13-6-7-17-19(9-13)33-21(29-17)20-27-15-4-2-3-5-16(15)28-20/h2-10,30H,11H2,1H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281549
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES Fc1ncc(cc1NS(=O)(=O)CC(F)(F)F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H13F4N5O3S/c22-18-16(30-34(31,32)10-21(23,24)25)7-12(9-26-18)11-5-6-15-17(8-11)33-20(29-15)19-27-13-3-1-2-4-14(13)28-19/h1-9,30H,10H2,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281489
PNG
(US10022387, Example 15 | US10596184, Example 15 | ...)
Show SMILES CC(C)Oc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H18N4O2/c1-13(2)27-16-9-15(11-23-12-16)14-7-8-19-20(10-14)28-22(26-19)21-24-17-5-3-4-6-18(17)25-21/h3-13H,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281501
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16FN5O3S/c1-2-31(28,29)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281484
PNG
(US10022387, Example 10 | US10596184, Example 10 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C20H13FN4O2/c1-26-14-6-12(9-22-10-14)11-2-4-16-18(7-11)27-20(25-16)19-23-15-5-3-13(21)8-17(15)24-19/h2-10H,1H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281532
PNG
(US10022387, Example 58 | US10596184, Example 58 | ...)
Show SMILES OC1CCN(C1)S(=O)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281551
PNG
(N-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES FC(F)(F)CS(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H14F3N5O3S/c22-21(23,24)11-33(30,31)29-14-7-13(9-25-10-14)12-5-6-17-18(8-12)32-20(28-17)19-26-15-3-1-2-4-16(15)27-19/h1-10,29H,11H2,(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281482
PNG
(US10022387, Example 7 | US10596184, Example 7 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(ccc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H16N4O/c1-27-17-11-16(12-23-13-17)14-6-8-18-15(10-14)7-9-21(24-18)22-25-19-4-2-3-5-20(19)26-22/h2-13H,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281511
PNG
(US10022387, Example 37 | US10596184, Example 37 | ...)
Show SMILES CN(C)S(=O)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N5O3S/c1-26(2)30(27,28)15-9-14(11-22-12-15)13-7-8-18-19(10-13)29-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281514
PNG
(N-(5-(2-(1H- Imidazol-2- yl)benzo[d]oxazol- 6-yl)p...)
Show SMILES CCS(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C17H15N5O3S/c1-2-26(23,24)22-13-7-12(9-18-10-13)11-3-4-14-15(8-11)25-17(21-14)16-19-5-6-20-16/h3-10,22H,2H2,1H3,(H,19,20)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281531
PNG
(US10022387, Example 57 | US10596184, Example 57 | ...)
Show SMILES CCn1ncc2ncc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H16N6O/c1-2-28-19-9-14(11-23-18(19)12-24-28)13-7-8-17-20(10-13)29-22(27-17)21-25-15-5-3-4-6-16(15)26-21/h3-12H,2H2,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281536
PNG
(US10022387, Example 62 | US10596184, Example 62 | ...)
Show SMILES Cc1nc([nH]c1C)-c1nc2ccc(cc2o1)-c1cncc(c1)S(C)(=O)=O
Show InChI InChI=1S/C18H16N4O3S/c1-10-11(2)21-17(20-10)18-22-15-5-4-12(7-16(15)25-18)13-6-14(9-19-8-13)26(3,23)24/h4-9H,1-3H3,(H,20,21)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM294399
PNG
(2-(1H-Benzo[d]imidazol- 2-yl)-6-(6-fluoro- 5-metho...)
Show SMILES COc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H13FN4O2/c1-26-17-9-12(10-22-18(17)21)11-6-7-15-16(8-11)27-20(25-15)19-23-13-4-2-3-5-14(13)24-19/h2-10H,1H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281545
PNG
(2-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES OC(=O)Cc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H14N4O3/c26-19(27)8-12-7-14(11-22-10-12)13-5-6-17-18(9-13)28-21(25-17)20-23-15-3-1-2-4-16(15)24-20/h1-7,9-11H,8H2,(H,23,24)(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM294350
PNG
(N-(5-(2-(1H- Benzo[d]imidazol-2- yl)benzo[d]oxazol...)
Show SMILES O=S(=O)(Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1)N1CCCCC1
Show InChI InChI=1S/C24H22N6O3S/c31-34(32,30-10-4-1-5-11-30)29-18-12-17(14-25-15-18)16-8-9-21-22(13-16)33-24(28-21)23-26-19-6-2-3-7-20(19)27-23/h2-3,6-9,12-15,29H,1,4-5,10-11H2,(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM294363
PNG
(N-(5-(2-(1H- Benzo[d]imidazol-2- yl)benzo[d]oxazol...)
Show SMILES CC(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H15N5O2/c1-12(27)23-15-8-14(10-22-11-15)13-6-7-18-19(9-13)28-21(26-18)20-24-16-4-2-3-5-17(16)25-20/h2-11H,1H3,(H,23,27)(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281516
PNG
(US10022387, Example 42 | US10596184, Example 42 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cnc([nH]1)C1CC1
Show InChI InChI=1S/C19H16N4O2/c1-24-14-6-13(8-20-9-14)12-4-5-15-17(7-12)25-19(23-15)16-10-21-18(22-16)11-2-3-11/h4-11H,2-3H2,1H3,(H,21,22)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281483
PNG
(US10022387, Example 8 | US10596184, Example 8 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccc(Br)cc2[nH]1
Show InChI InChI=1S/C20H13BrN4O2/c1-26-14-6-12(9-22-10-14)11-2-4-16-18(7-11)27-20(25-16)19-23-15-5-3-13(21)8-17(15)24-19/h2-10H,1H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281492
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2- yl)benzo[d]oxazo...)
Show SMILES CCS(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N5O3S/c1-2-30(27,28)26-15-9-14(11-22-12-15)13-7-8-18-19(10-13)29-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12,26H,2H2,1H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281515
PNG
(N'-{5-[2-(1H- Imidazol-2-yl)-1,3- benzoxazol-6- yl...)
Show SMILES CN(C)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C17H16N6O3S/c1-23(2)27(24,25)22-13-7-12(9-18-10-13)11-3-4-14-15(8-11)26-17(21-14)16-19-5-6-20-16/h3-10,22H,1-2H3,(H,19,20)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281490
PNG
(US10022387, Example 16 | US10596184, Example 16 | ...)
Show SMILES FC(F)Oc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H12F2N4O2/c21-20(22)27-13-7-12(9-23-10-13)11-5-6-16-17(8-11)28-19(26-16)18-24-14-3-1-2-4-15(14)25-18/h1-10,20H,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281476
PNG
(US10022387, Example 1 | US10596184, Example 1 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C16H12N4O2/c1-21-12-6-11(8-17-9-12)10-2-3-13-14(7-10)22-16(20-13)15-18-4-5-19-15/h2-9H,1H3,(H,18,19)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281479
PNG
(US10022387, Example 4 | US10022387, Example 5 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C21H15N3O2/c1-25-16-8-15(11-22-12-16)13-6-7-18-20(10-13)26-21(24-18)19-9-14-4-2-3-5-17(14)23-19/h2-12,23H,1H3
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281495
PNG
(N'-{5-[2-(1H- Benzimidazol-2- yl)-1,3- benzoxazol-...)
Show SMILES CN(C)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H18N6O3S/c1-27(2)31(28,29)26-15-9-14(11-22-12-15)13-7-8-18-19(10-13)30-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12,26H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281537
PNG
(US10022387, Example 63 | US10596184, Example 63 | ...)
Show SMILES CCS(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc(C)c(C)[nH]1
Show InChI InChI=1S/C19H19N5O3S/c1-4-28(25,26)24-15-7-14(9-20-10-15)13-5-6-16-17(8-13)27-19(23-16)18-21-11(2)12(3)22-18/h5-10,24H,4H2,1-3H3,(H,21,22)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281477
PNG
(US10022387, Example 2 | US10596184, Example 2 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cnc[nH]1
Show InChI InChI=1S/C16H12N4O2/c1-21-12-4-11(6-17-7-12)10-2-3-13-15(5-10)22-16(20-13)14-8-18-9-19-14/h2-9H,1H3,(H,18,19)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281478
PNG
(US10022387, Example 3 | US10596184, Example 3 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1ccc[nH]1
Show InChI InChI=1S/C17H13N3O2/c1-21-13-7-12(9-18-10-13)11-4-5-14-16(8-11)22-17(20-14)15-3-2-6-19-15/h2-10,19H,1H3
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281509
PNG
(US10022387, Example 35 | US10596184, Example 35 | ...)
Show SMILES N#Cc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H11N5O/c21-9-12-7-14(11-22-10-12)13-5-6-17-18(8-13)26-20(25-17)19-23-15-3-1-2-4-16(15)24-19/h1-8,10-11H,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281512
PNG
(US10022387, Example 38 | US10596184, Example 38 | ...)
Show SMILES O=S(=O)(N1CCOCC1)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H19N5O4S/c29-33(30,28-7-9-31-10-8-28)17-11-16(13-24-14-17)15-5-6-20-21(12-15)32-23(27-20)22-25-18-3-1-2-4-19(18)26-22/h1-6,11-14H,7-10H2,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281516
PNG
(US10022387, Example 42 | US10596184, Example 42 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cnc([nH]1)C1CC1
Show InChI InChI=1S/C19H16N4O2/c1-24-14-6-13(8-20-9-14)12-4-5-15-17(7-12)25-19(23-15)16-10-21-18(22-16)11-2-3-11/h4-11H,2-3H2,1H3,(H,21,22)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281517
PNG
(6-(5- Methoxypyridin- 3-yl)-2-(2- (tetrahydrofuran...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cnc([nH]1)C1CCOC1
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281477
PNG
(US10022387, Example 2 | US10596184, Example 2 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cnc[nH]1
Show InChI InChI=1S/C16H12N4O2/c1-21-12-4-11(6-17-7-12)10-2-3-13-15(5-10)22-16(20-13)14-8-18-9-19-14/h2-9H,1H3,(H,18,19)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281488
PNG
(US10022387, Example 14 | US10596184, Example 14 | ...)
Show SMILES Oc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C19H12N4O2/c24-13-7-12(9-20-10-13)11-5-6-16-17(8-11)25-19(23-16)18-21-14-3-1-2-4-15(14)22-18/h1-10,24H,(H,21,22)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281489
PNG
(US10022387, Example 15 | US10596184, Example 15 | ...)
Show SMILES CC(C)Oc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H18N4O2/c1-13(2)27-16-9-15(11-23-12-16)14-7-8-19-20(10-14)28-22(26-19)21-24-17-5-3-4-6-18(17)25-21/h3-13H,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281508
PNG
(US10022387, Example 34 | US10596184, Example 34 | ...)
Show SMILES CN(C)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N5O/c1-26(2)15-9-14(11-22-12-15)13-7-8-18-19(10-13)27-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281520
PNG
(US10022387, Example 46 | US10596184, Example 46 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cc(C)n[nH]1
Show InChI InChI=1S/C17H14N4O2/c1-10-5-15(21-20-10)17-19-14-4-3-11(7-16(14)23-17)12-6-13(22-2)9-18-8-12/h3-9H,1-2H3,(H,20,21)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM294399
PNG
(2-(1H-Benzo[d]imidazol- 2-yl)-6-(6-fluoro- 5-metho...)
Show SMILES COc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H13FN4O2/c1-26-17-9-12(10-22-18(17)21)11-6-7-15-16(8-11)27-20(25-15)19-23-13-4-2-3-5-14(13)24-19/h2-10H,1H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281552
PNG
(N-(2-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES CCS(=O)(=O)Nc1cc(ncc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16FN5O3S/c1-2-31(28,29)27-18-10-17(23-11-13(18)22)12-7-8-16-19(9-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11H,2H2,1H3,(H,23,27)(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281552
PNG
(N-(2-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES CCS(=O)(=O)Nc1cc(ncc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16FN5O3S/c1-2-31(28,29)27-18-10-17(23-11-13(18)22)12-7-8-16-19(9-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11H,2H2,1H3,(H,23,27)(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281487
PNG
(US10022387, Example 13 | US10596184, Example 13 | ...)
Show SMILES Brc1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H8BrN3O/c15-8-5-6-11-12(7-8)19-14(18-11)13-16-9-3-1-2-4-10(9)17-13/h1-7H,(H,16,17)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281517
PNG
(6-(5- Methoxypyridin- 3-yl)-2-(2- (tetrahydrofuran...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cnc([nH]1)C1CCOC1
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n/an/a<5.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281518
PNG
(6-(5- Methoxypyridin- 3-yl)-2-(2- phenyl-1H- imida...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C22H16N4O2/c1-27-17-9-16(11-23-12-17)15-7-8-18-20(10-15)28-22(26-18)19-13-24-21(25-19)14-5-3-2-4-6-14/h2-13H,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281519
PNG
(2-(2-Ethyl-1H- imidazol-5-yl)- 6-(5- methoxypyridi...)
Show SMILES CCc1ncc([nH]1)-c1nc2ccc(cc2o1)-c1cncc(OC)c1
Show InChI InChI=1S/C18H16N4O2/c1-3-17-20-10-15(21-17)18-22-14-5-4-11(7-16(14)24-18)12-6-13(23-2)9-19-8-12/h4-10H,3H2,1-2H3,(H,20,21)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281523
PNG
(US10022387, Example 49 | US10596184, Example 49 | ...)
Show SMILES c1n[nH]c2ccc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H13N5O/c1-2-4-17-16(3-1)23-20(24-17)21-25-18-8-6-13(10-19(18)27-21)12-5-7-15-14(9-12)11-22-26-15/h1-11H,(H,22,26)(H,23,24)
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n/an/a<5.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM437740
PNG
(US10596184, Example 54)
Show SMILES CCn1ncc2ccc(cc12)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H17N5O/c1-2-28-20-11-14(7-8-16(20)13-24-28)15-9-10-19-21(12-15)29-23(27-19)22-25-17-5-3-4-6-18(17)26-22/h3-13H,2H2,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM437785
PNG
(US10596184, Example 55)
Show SMILES C(N1CCN(CC1)c1ccc2nc(oc2c1)C1=Nc2ccccc2[Na]1)c1ccccc1
Show InChI InChI=1S/C25H22N4O.Na/c1-3-7-20(8-4-1)19-28-13-15-29(16-14-28)22-11-12-23-24(17-22)30-25(27-23)18-26-21-9-5-2-6-10-21;/h1-9,11-12,17H,13-16,19H2;
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM294399
PNG
(2-(1H-Benzo[d]imidazol- 2-yl)-6-(6-fluoro- 5-metho...)
Show SMILES COc1cc(cnc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H13FN4O2/c1-26-17-9-12(10-22-18(17)21)11-6-7-15-16(8-11)27-20(25-15)19-23-13-4-2-3-5-14(13)24-19/h2-10H,1H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281554
PNG
(US10022387, Example 80 | US10596184, Example 80 | ...)
Show SMILES CCS(=O)(=O)Nc1cc(cc(F)c1OC)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H19FN4O4S/c1-3-33(29,30)28-19-11-14(10-15(24)21(19)31-2)13-8-9-18-20(12-13)32-23(27-18)22-25-16-6-4-5-7-17(16)26-22/h4-12,28H,3H2,1-2H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281476
PNG
(US10022387, Example 1 | US10596184, Example 1 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C16H12N4O2/c1-21-12-6-11(8-17-9-12)10-2-3-13-14(7-10)22-16(20-13)15-18-4-5-19-15/h2-9H,1H3,(H,18,19)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281478
PNG
(US10022387, Example 3 | US10596184, Example 3 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1ccc[nH]1
Show InChI InChI=1S/C17H13N3O2/c1-21-13-7-12(9-18-10-13)11-4-5-14-16(8-11)22-17(20-14)15-3-2-6-19-15/h2-10,19H,1H3
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281482
PNG
(US10022387, Example 7 | US10596184, Example 7 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(ccc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H16N4O/c1-27-17-11-16(12-23-13-17)14-6-8-18-15(10-14)7-9-21(24-18)22-25-19-4-2-3-5-20(19)26-22/h2-13H,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281520
PNG
(US10022387, Example 46 | US10596184, Example 46 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cc(C)n[nH]1
Show InChI InChI=1S/C17H14N4O2/c1-10-5-15(21-20-10)17-19-14-4-3-11(7-16(14)23-17)12-6-13(22-2)9-18-8-12/h3-9H,1-2H3,(H,20,21)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281521
PNG
(US10022387, Example 47 | US10596184, Example 47 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cc(n[nH]1)-c1ccccc1
Show InChI InChI=1S/C22H16N4O2/c1-27-17-9-16(12-23-13-17)15-7-8-18-21(10-15)28-22(24-18)20-11-19(25-26-20)14-5-3-2-4-6-14/h2-13H,1H3,(H,25,26)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM294363
PNG
(N-(5-(2-(1H- Benzo[d]imidazol-2- yl)benzo[d]oxazol...)
Show SMILES CC(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H15N5O2/c1-12(27)23-15-8-14(10-22-11-15)13-6-7-18-19(9-13)28-21(26-18)20-24-16-4-2-3-5-17(16)25-20/h2-11H,1H3,(H,23,27)(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281522
PNG
(US10022387, Example 48 | US10596184, Example 48 | ...)
Show SMILES C(c1ccccc1)n1cc(cn1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C24H17N5O/c1-2-6-16(7-3-1)14-29-15-18(13-25-29)17-10-11-21-22(12-17)30-24(28-21)23-26-19-8-4-5-9-20(19)27-23/h1-13,15H,14H2,(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281527
PNG
(US10022387, Example 53 | US10022387, Example 54 | ...)
Show SMILES CCn1cc2ccc(cc2n1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H17N5O/c1-2-28-13-16-8-7-14(11-20(16)27-28)15-9-10-19-21(12-15)29-23(26-19)22-24-17-5-3-4-6-18(17)25-22/h3-13H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM437785
PNG
(US10596184, Example 55)
Show SMILES C(N1CCN(CC1)c1ccc2nc(oc2c1)C1=Nc2ccccc2[Na]1)c1ccccc1
Show InChI InChI=1S/C25H22N4O.Na/c1-3-7-20(8-4-1)19-28-13-15-29(16-14-28)22-11-12-23-24(17-22)30-25(27-23)18-26-21-9-5-2-6-10-21;/h1-9,11-12,17H,13-16,19H2;
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281530
PNG
(US10022387, Example 56 | US10596184, Example 56 | ...)
Show SMILES Nc1ncc(cc1C(F)(F)F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)12-7-11(9-25-17(12)24)10-5-6-15-16(8-10)29-19(28-15)18-26-13-3-1-2-4-14(13)27-18/h1-9H,(H2,24,25)(H,26,27)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281534
PNG
(US10022387, Example 60 | US10596184, Example 60 | ...)
Show SMILES CCS(=O)(=O)Nc1cc(ccc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H17FN4O3S/c1-2-31(28,29)27-19-11-13(7-9-15(19)23)14-8-10-18-20(12-14)30-22(26-18)21-24-16-5-3-4-6-17(16)25-21/h3-12,27H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM294402
PNG
(2-(1H-Benzo[d]imidazol- 2-yl)-6-(5-(dimethyl- phos...)
Show SMILES CP(C)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N4O2P/c1-28(2,26)15-9-14(11-22-12-15)13-7-8-18-19(10-13)27-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281481
PNG
(US10022387, Example 6 | US10596184, Example 6 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(sc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H14N4OS/c1-25-14-8-13(10-21-11-14)12-6-7-17-18(9-12)26-20(24-17)19-22-15-4-2-3-5-16(15)23-19/h2-11H,1H3,(H,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281533
PNG
(US10022387, Example 59 | US10596184, Example 59 | ...)
Show SMILES CCNS(=O)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N5O3S/c1-2-23-30(27,28)15-9-14(11-22-12-15)13-7-8-18-19(10-13)29-21(26-18)20-24-16-5-3-4-6-17(16)25-20/h3-12,23H,2H2,1H3,(H,24,25)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM294335
PNG
(2-(1H-Benzo[d]imidazol-2-yl)-6-(5-methoxypyridin-3...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H14N4O2/c1-25-14-8-13(10-21-11-14)12-6-7-17-18(9-12)26-20(24-17)19-22-15-4-2-3-5-16(15)23-19/h2-11H,1H3,(H,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281487
PNG
(US10022387, Example 13 | US10596184, Example 13 | ...)
Show SMILES Brc1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H8BrN3O/c15-8-5-6-11-12(7-8)19-14(18-11)13-16-9-3-1-2-4-10(9)17-13/h1-7H,(H,16,17)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281498
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CC(C)S(=O)(=O)Nc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H19N5O3S/c1-13(2)31(28,29)27-16-9-15(11-23-12-16)14-7-8-19-20(10-14)30-22(26-19)21-24-17-5-3-4-6-18(17)25-21/h3-13,27H,1-2H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281525
PNG
(US10022387, Example 51 | US10596184, Example 51 | ...)
Show SMILES Fc1ccc(cc1F)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H11F2N3O/c21-13-7-5-11(9-14(13)22)12-6-8-17-18(10-12)26-20(25-17)19-23-15-3-1-2-4-16(15)24-19/h1-10H,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281536
PNG
(US10022387, Example 62 | US10596184, Example 62 | ...)
Show SMILES Cc1nc([nH]c1C)-c1nc2ccc(cc2o1)-c1cncc(c1)S(C)(=O)=O
Show InChI InChI=1S/C18H16N4O3S/c1-10-11(2)21-17(20-10)18-22-15-5-4-12(7-16(15)25-18)13-6-14(9-19-8-13)26(3,23)24/h4-9H,1-3H3,(H,20,21)
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n/an/a<5.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281481
PNG
(US10022387, Example 6 | US10596184, Example 6 | US...)
Show SMILES COc1cncc(c1)-c1ccc2nc(sc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H14N4OS/c1-25-14-8-13(10-21-11-14)12-6-7-17-18(9-12)26-20(24-17)19-22-15-4-2-3-5-16(15)23-19/h2-11H,1H3,(H,22,23)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281484
PNG
(US10022387, Example 10 | US10596184, Example 10 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C20H13FN4O2/c1-26-14-6-12(9-22-10-14)11-2-4-16-18(7-11)27-20(25-16)19-23-15-5-3-13(21)8-17(15)24-19/h2-10H,1H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281485
PNG
(US10022387, Example 11 | US10596184, Example 11 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2cc(C)ccc2[nH]1
Show InChI InChI=1S/C21H16N4O2/c1-12-3-5-16-18(7-12)24-20(23-16)21-25-17-6-4-13(9-19(17)27-21)14-8-15(26-2)11-22-10-14/h3-11H,1-2H3,(H,23,24)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281486
PNG
(US10022387, Example 12 | US10596184, Example 12 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2c(C)cccc2[nH]1
Show InChI InChI=1S/C21H16N4O2/c1-12-4-3-5-17-19(12)25-20(23-17)21-24-16-7-6-13(9-18(16)27-21)14-8-15(26-2)11-22-10-14/h3-11H,1-2H3,(H,23,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281500
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16ClN5O3S/c1-2-31(28,29)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,2H2,1H3,(H,24,25)
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Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281510
PNG
(US10022387, Example 36 | US10596184, Example 36 | ...)
Show SMILES CS(=O)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C20H14N4O3S/c1-28(25,26)14-8-13(10-21-11-14)12-6-7-17-18(9-12)27-20(24-17)19-22-15-4-2-3-5-16(15)23-19/h2-11H,1H3,(H,22,23)
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n/an/a<5.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))		BDBM281519
PNG
(2-(2-Ethyl-1H- imidazol-5-yl)- 6-(5- methoxypyridi...)
Show SMILES CCc1ncc([nH]1)-c1nc2ccc(cc2o1)-c1cncc(OC)c1
Show InChI InChI=1S/C18H16N4O2/c1-3-17-20-10-15(21-17)18-22-14-5-4-11(7-16(14)24-18)12-6-13(23-2)9-19-8-12/h4-10H,3H2,1-2H3,(H,20,21)
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Incyte Corporation

US Patent


Assay Description
PI3K-gamma:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281521
PNG
(US10022387, Example 47 | US10596184, Example 47 | ...)
Show SMILES COc1cncc(c1)-c1ccc2nc(oc2c1)-c1cc(n[nH]1)-c1ccccc1
Show InChI InChI=1S/C22H16N4O2/c1-27-17-9-16(12-23-13-17)15-7-8-18-21(10-15)28-22(24-18)20-11-19(25-26-20)14-5-3-2-4-6-14/h2-13H,1H3,(H,25,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM281545
PNG
(2-(5-(2-(1H-Benzo[d]imidazol-2- yl)benzo[d]oxazol-...)
Show SMILES OC(=O)Cc1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H14N4O3/c26-19(27)8-12-7-14(11-22-10-12)13-5-6-17-18(9-13)28-21(25-17)20-23-15-3-1-2-4-16(15)24-20/h1-7,9-11H,8H2,(H,23,24)(H,26,27)
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n/an/a<5.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM294402
PNG
(2-(1H-Benzo[d]imidazol- 2-yl)-6-(5-(dimethyl- phos...)
Show SMILES CP(C)(=O)c1cncc(c1)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H17N4O2P/c1-28(2,26)15-9-14(11-22-12-15)13-7-8-18-19(10-13)27-21(25-18)20-23-16-5-3-4-6-17(16)24-20/h3-12H,1-2H3,(H,23,24)
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n/an/a<5.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PI3Kdelta: The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 2...

US Patent US10596184 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%