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Patent code US10597366

Compile Data Set for Download or QSAR

Found 413 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373005
PNG
(US10597366, Compound 159 | US9896418, Compound 159)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)C(O)c12
Show InChI InChI=1S/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373021
PNG
(US10597366, Compound 196 | US9896418, Compound 196)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C16H10F6O4S/c17-9-2-1-7(5-10(9)18)26-11-3-4-12(27(24,25)15(19)20)13-8(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373024
PNG
(US10597366, Compound 225 | US9896418, Compound 225)
Show SMILES O[C@@H]1[C@H](F)Cc2c1c(ccc2Oc1cncc(c1)C#N)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C16H10F4N2O4S/c17-11-4-10-12(26-9-3-8(5-21)6-22-7-9)1-2-13(14(10)15(11)23)27(24,25)16(18,19)20/h1-3,6-7,11,15,23H,4H2/t11-,15-/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373050
PNG
(US10597366, Compound 316 | US9896418, Compound 316...)
Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C18H11F4N3O3S/c1-29(27,25-8-24)13-3-2-12(14-15(13)17(26)18(21,22)16(14)20)28-11-5-9(7-23)4-10(19)6-11/h2-6,16-17,26H,1H3/t16-,17+,29?/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372972
PNG
(US10597366, Compound 11 | US9896418, Compound 11)
Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372989
PNG
(US10597366, Compound 55 | US9896418, Compound 55)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(F)c1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C16H11F5O4S/c17-8-5-9(18)7-10(6-8)25-13-3-4-14(26(23,24)16(19,20)21)15-11(13)1-2-12(15)22/h3-7,12,22H,1-2H2/t12-/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373004
PNG
(US10597366, Compound 158 | US9896418, Compound 158)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(Cl)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C16H10ClF5O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373012
PNG
(US10597366, Compound 166 | US9896418, Compound 166)
Show SMILES Cc1cc(Oc2ccc(c3[C@H](O)C(F)(F)Cc23)S(=O)(=O)CF)cc(c1)C#N
Show InChI InChI=1S/C18H14F3NO4S/c1-10-4-11(8-22)6-12(5-10)26-14-2-3-15(27(24,25)9-19)16-13(14)7-18(20,21)17(16)23/h2-6,17,23H,7,9H2,1H3/t17-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373015
PNG
(US10597366, Compound 185 | US9896418, Compound 185)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C17H9F6NO4S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(26,27)17(21,22)23)14-11(12)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373008
PNG
(US10597366, Compound 163 | US9896418, Compound 163)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373044
PNG
(US10597366, Compound 306 | US9896418, Compound 305...)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=N)(=O)C(F)(F)F
Show InChI InChI=1S/C17H10F6N2O3S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(25,27)17(21,22)23)14-11(12)6-16(19,20)15(14)26/h1-5,15,25-26H,6H2/t15-,29?/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373047
PNG
(US10597366, Compound 309 | US9896418, Compound 309)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(F)c1)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C15H9F6NO4S/c16-7-3-8(6-22-5-7)26-10-1-2-11(27(24,25)15(19,20)21)12-9(10)4-14(17,18)13(12)23/h1-3,5-6,13,23H,4H2/t13-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372964
PNG
(US10597366, Compound 8 | US9896418, Compound 8)
Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(Cl)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C16H10ClF5O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373016
PNG
(US10597366, Compound 186 | US9896418, Compound 186)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(Cl)c1)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C15H9ClF5NO4S/c16-7-3-8(6-22-5-7)26-10-1-2-11(27(24,25)15(19,20)21)12-9(10)4-14(17,18)13(12)23/h1-3,5-6,13,23H,4H2/t13-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373042
PNG
(US10597366, Compound 273 | US9896418, Compound 273)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2C(F)(F)F
Show InChI InChI=1S/C17H9F6NO2/c18-9-3-8(7-24)4-10(5-9)26-13-2-1-12(17(21,22)23)14-11(13)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372966
PNG
(US10597366, Compound 9 | US9896418, Compound 9)
Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372990
PNG
(US10597366, Compound 60 | US9896418, Compound 60)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(F)c1)S(=O)(=O)CF
Show InChI InChI=1S/C16H13F3O4S/c17-8-24(21,22)15-4-3-14(12-1-2-13(20)16(12)15)23-11-6-9(18)5-10(19)7-11/h3-7,13,20H,1-2,8H2/t13-/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372991
PNG
(US10597366, Compound 63 | US9896418, Compound 63)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)CF
Show InChI InChI=1S/C17H11F4NO4S/c18-8-27(24,25)14-2-1-13(12-6-17(20,21)16(23)15(12)14)26-11-4-9(7-22)3-10(19)5-11/h1-5,16,23H,6,8H2/t16-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373006
PNG
(US10597366, Compound 161 | US9896418, Compound 161)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373028
PNG
(US10597366, Compound 233 | US9896418, Compound 233)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C16H9F7O4S/c17-9-2-1-7(5-10(9)18)27-11-3-4-12(28(25,26)16(21,22)23)13-8(11)6-15(19,20)14(13)24/h1-5,14,24H,6H2/t14-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373031
PNG
(US10597366, Compound 236 | US9896418, Compound 236)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cccc(c1)C#N)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C17H11F4NO4S/c18-16(19)27(24,25)13-5-4-12(11-7-17(20,21)15(23)14(11)13)26-10-3-1-2-9(6-10)8-22/h1-6,15-16,23H,7H2/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373043
PNG
(US10597366, Compound 304 | US9896418, Compound 304)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(Br)c2)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C16H12BrF3O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM438062
PNG
(US10597366, Compound 317 | US10597366, Compound 32...)
Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@H](F)C(F)(F)[C@H](O)c12
Show InChI InChI=1S/C18H11F4N3O3S/c1-29(27,25-8-24)13-3-2-12(14-15(13)17(26)18(21,22)16(14)20)28-11-5-9(7-23)4-10(19)6-11/h2-6,16-17,26H,1H3/t16-,17+,29?/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437780
PNG
(US10597366, Compound 65)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(Cl)c1)ccc2S(=O)(=O)CF
Show InChI InChI=1S/C16H11ClF4O4S/c17-8-3-9(19)5-10(4-8)25-12-1-2-13(26(23,24)7-18)14-11(12)6-16(20,21)15(14)22/h1-5,15,22H,6-7H2/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437887
PNG
(US10597366, Compound 160)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(Cl)c2)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C16H12ClF3O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437929
PNG
(US10597366, Compound 200)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(c1)C#N)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C17H10F5NO4S/c18-11-2-1-9(5-8(11)7-23)27-12-3-4-13(28(25,26)16(19)20)14-10(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373044
PNG
(US10597366, Compound 306 | US9896418, Compound 305...)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=N)(=O)C(F)(F)F
Show InChI InChI=1S/C17H10F6N2O3S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(25,27)17(21,22)23)14-11(12)6-16(19,20)15(14)26/h1-5,15,25-26H,6H2/t15-,29?/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM438074
PNG
(US10597366, Compound 329)
Show SMILES CS(=O)(=O)c1ccc(Oc2cncc(F)c2)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C15H11F4NO4S/c1-25(22,23)10-3-2-9(24-8-4-7(16)5-20-6-8)11-12(10)14(21)15(18,19)13(11)17/h2-6,13-14,21H,1H3/t13-,14+/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372961
PNG
(US10597366, Compound 2 | US9896418, Compound 2)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(F)c1)S(=O)(=O)C(F)F
Show InChI InChI=1S/C16H12F4O4S/c17-8-5-9(18)7-10(6-8)24-13-3-4-14(25(22,23)16(19)20)15-11(13)1-2-12(15)21/h3-7,12,16,21H,1-2H2/t12-/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437717
PNG
(US10597366, Compound 6)
Show SMILES COc1cc(F)cc(Oc2ccc(c3[C@H](O)CCc23)S(=O)(=O)C(F)F)c1
Show InChI InChI=1S/C17H15F3O5S/c1-24-10-6-9(18)7-11(8-10)25-14-4-5-15(26(22,23)17(19)20)16-12(14)2-3-13(16)21/h4-8,13,17,21H,2-3H2,1H3/t13-/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372987
PNG
(US10597366, Compound 34 | US9896418, Compound 34)
Show SMILES Cc1c(C#N)c(Oc2cc(F)cc(F)c2)ccc1S(=O)(=O)C(F)F
Show InChI InChI=1S/C15H9F4NO3S/c1-8-12(7-20)13(2-3-14(8)24(21,22)15(18)19)23-11-5-9(16)4-10(17)6-11/h2-6,15H,1H3
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437773
PNG
(US10597366, Compound 58)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(F)c1)C(F)(F)F
Show InChI InChI=1S/C16H11F5O2/c17-8-5-9(18)7-10(6-8)23-14-4-2-12(16(19,20)21)15-11(14)1-3-13(15)22/h2,4-7,13,22H,1,3H2/t13-/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372992
PNG
(US10597366, Compound 64 | US9896418, Compound 64)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)CF
Show InChI InChI=1S/C16H11F5O4S/c17-7-26(23,24)13-2-1-12(11-6-16(20,21)15(22)14(11)13)25-10-4-8(18)3-9(19)5-10/h1-5,15,22H,6-7H2/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372960
PNG
(US10597366, Compound 1 | US9896418, Compound 1)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(Cl)c1)S(=O)(=O)C(F)F
Show InChI InChI=1S/C16H12ClF3O4S/c17-8-5-9(18)7-10(6-8)24-13-3-4-14(25(22,23)16(19)20)15-11(13)1-2-12(15)21/h3-7,12,16,21H,1-2H2/t12-/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373017
PNG
(US10597366, Compound 188 | US9896418, Compound 188)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)c(F)c(F)c1)ccc2S(=O)(=O)CF
Show InChI InChI=1S/C16H10F6O4S/c17-6-27(24,25)12-2-1-11(8-5-16(21,22)15(23)13(8)12)26-7-3-9(18)14(20)10(19)4-7/h1-4,15,23H,5-6H2/t15-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437923
PNG
(US10597366, Compound 194)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(Br)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C16H10BrF5O4S/c17-9-5-7(1-2-10(9)18)26-11-3-4-12(27(24,25)15(19)20)13-8(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373019
PNG
(US10597366, Compound 191 | US9896418, Compound 191)
Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)C(O)c12
Show InChI InChI=1S/C17H12F4N2O3S/c1-27(25,23-8-22)14-3-2-13(12-7-17(20,21)16(24)15(12)14)26-11-5-9(18)4-10(19)6-11/h2-6,16,24H,7H2,1H3
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373041
PNG
(US10597366, Compound 292 | US9896418, Compound 292)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C17H11F4NO4S/c1-27(24,25)12-3-2-11(13-14(12)16(23)17(20,21)15(13)19)26-10-5-8(7-22)4-9(18)6-10/h2-6,15-16,23H,1H3/t15-,16+/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437738
PNG
(US10597366, Compound 26)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(Cl)c1)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C16H10ClF5O4S/c17-9-5-7(1-2-10(9)18)26-11-3-4-12(27(24,25)15(19)20)13-8(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437774
PNG
(US10597366, Compound 59)
Show SMILES OC1CCc2c1c(ccc2Oc1cc(F)cc(F)c1)S(=O)(=O)CF
Show InChI InChI=1S/C16H13F3O4S/c17-8-24(21,22)15-4-3-14(12-1-2-13(20)16(12)15)23-11-6-9(18)5-10(19)7-11/h3-7,13,20H,1-2,8H2
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437777
PNG
(US10597366, Compound 62)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(c1)C#N)S(=O)(=O)CF
Show InChI InChI=1S/C17H13F2NO4S/c18-9-25(22,23)16-4-3-15(13-1-2-14(21)17(13)16)24-12-6-10(8-20)5-11(19)7-12/h3-7,14,21H,1-2,9H2/t14-/m1/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437930
PNG
(US10597366, Compound 201)
Show SMILES Cc1cncc(Oc2ccc(c3[C@H](O)C(F)(F)Cc23)S(C)(=O)=O)n1
Show InChI InChI=1S/C15H14F2N2O4S/c1-8-6-18-7-12(19-8)23-10-3-4-11(24(2,21)22)13-9(10)5-15(16,17)14(13)20/h3-4,6-7,14,20H,5H2,1-2H3/t14-/m0/s1
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Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437771
PNG
(US10597366, Compound 56)
Show SMILES O[C@@H]1CCc2c1c(ccc2Oc1cc(F)cc(Cl)c1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C16H11ClF4O4S/c17-8-5-9(18)7-10(6-8)25-13-3-4-14(26(23,24)16(19,20)21)15-11(13)1-2-12(15)22/h3-7,12,22H,1-2H2/t12-/m1/s1
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n/an/a<5n/an/an/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM438089
PNG
(US10597366, Compound 344 | US10597366, Compound 34...)
Show SMILES O[C@H]1c2c([C@@H](F)C1(F)F)c(Oc1cncc(c1)C#N)ccc2S(=O)(=O)CF
Show InChI InChI=1S/C16H10F4N2O4S/c17-7-27(24,25)11-2-1-10(26-9-3-8(4-21)5-22-6-9)12-13(11)15(23)16(19,20)14(12)18/h1-3,5-6,14-15,23H,7H2/t14-,15+/m1/s1
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n/an/a 6.70n/an/an/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM438076
PNG
(US10597366, Compound 331)
Show SMILES CS(=O)(=O)c1ccc(Oc2cncc(Cl)c2)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C15H11ClF3NO4S/c1-25(22,23)10-3-2-9(24-8-4-7(16)5-20-6-8)11-12(10)14(21)15(18,19)13(11)17/h2-6,13-14,21H,1H3/t13-,14+/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM372976
PNG
(US10597366, Compound 15 | US9896418, Compound 15)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F
Show InChI InChI=1S/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2/t15-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373008
PNG
(US10597366, Compound 163 | US9896418, Compound 163)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/m0/s1
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n/an/a 8.5n/an/an/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM373040
PNG
(US10597366, Compound 289 | US9896418, Compound 289)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)[C@@H](F)[C@@H](O)c12
Show InChI InChI=1S/C17H12F3NO4S/c1-26(23,24)12-3-2-11(13-14(12)17(22)16(20)15(13)19)25-10-5-8(7-21)4-9(18)6-10/h2-6,15-17,22H,1H3/t15-,16-,17+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM437953
PNG
(US10597366, Compound 223)
Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)C(O)c12
Show InChI InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM438083
PNG
(US10597366, Compound 338)
Show SMILES NS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12
Show InChI InChI=1S/C16H10F4N2O4S/c17-8-3-7(6-21)4-9(5-8)26-10-1-2-11(27(22,24)25)13-12(10)14(18)16(19,20)15(13)23/h1-5,14-15,23H,(H2,22,24,25)/t14-,15+/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...


US Patent US10597366 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%