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Patent code US10597367

Compile Data Set for Download or QSAR

Found 724 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393747
PNG
(US10597367, Example 37 | US9969726, Example 37)
Show SMILES c1sc(nc1-c1cccc(c1)-c1cccc(c1)-c1nn[nH]n1)-c1ccccc1
Show InChI InChI=1S/C22H15N5S/c1-2-6-15(7-3-1)22-23-20(14-28-22)18-10-4-8-16(12-18)17-9-5-11-19(13-17)21-24-26-27-25-21/h1-14H,(H,24,25,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393748
PNG
(US10597367, Example 38 | US9969726, Example 38)
Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nsc(n1)-c1ccccc1
Show InChI InChI=1S/C20H13FN2S/c21-18-11-9-14(10-12-18)16-7-4-8-17(13-16)19-22-20(24-23-19)15-5-2-1-3-6-15/h1-13H
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n/an/an/an/a 50n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393750
PNG
(US10597367, Example 40 | US9969726, Example 40)
Show SMILES Fc1cccc(c1)-c1cccc(c1)-c1nsc(n1)-c1ccccc1
Show InChI InChI=1S/C20H13FN2S/c21-18-11-5-9-16(13-18)15-8-4-10-17(12-15)19-22-20(24-23-19)14-6-2-1-3-7-14/h1-13H
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n/an/an/an/a 400n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393751
PNG
(US10597367, Example 41 | US9969726, Example 41)
Show SMILES Fc1ccccc1-c1cccc(c1)-c1nsc(n1)-c1ccccc1
Show InChI InChI=1S/C20H13FN2S/c21-18-12-5-4-11-17(18)15-9-6-10-16(13-15)19-22-20(24-23-19)14-7-2-1-3-8-14/h1-13H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393753
PNG
(BDBM437895 | US9969726, Example 43)
Show SMILES Fc1cccc(c1)-c1cccc(c1)-c1nsc(n1)-c1ccoc1
Show InChI InChI=1S/C18H11FN2OS/c19-16-6-2-4-13(10-16)12-3-1-5-14(9-12)17-20-18(23-21-17)15-7-8-22-11-15/h1-11H
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n/an/an/an/a 3.43E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393753
PNG
(BDBM437895 | US9969726, Example 43)
Show SMILES Fc1cccc(c1)-c1cccc(c1)-c1nsc(n1)-c1ccoc1
Show InChI InChI=1S/C18H11FN2OS/c19-16-6-2-4-13(10-16)12-3-1-5-14(9-12)17-20-18(23-21-17)15-7-8-22-11-15/h1-11H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393755
PNG
(US10597367, Example 45 | US9969726, Example 45)
Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1csc(c1)-c1ccccc1
Show InChI InChI=1S/C22H15FS/c23-21-11-9-16(10-12-21)18-7-4-8-19(13-18)20-14-22(24-15-20)17-5-2-1-3-6-17/h1-15H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393757
PNG
(US10597367, Example 47 | US9969726, Example 47)
Show SMILES c1oc(nc1-c1cccc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NO/c1-3-8-16(9-4-1)18-12-7-13-19(14-18)20-15-23-21(22-20)17-10-5-2-6-11-17/h1-15H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393757
PNG
(US10597367, Example 47 | US9969726, Example 47)
Show SMILES c1oc(nc1-c1cccc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NO/c1-3-8-16(9-4-1)18-12-7-13-19(14-18)20-15-23-21(22-20)17-10-5-2-6-11-17/h1-15H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393758
PNG
(US10597367, Example 48 | US9969726, Example 48)
Show SMILES c1ccc(cc1)-c1nc(no1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H14N2O/c1-3-8-15(9-4-1)17-12-7-13-18(14-17)19-21-20(23-22-19)16-10-5-2-6-11-16/h1-14H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393760
PNG
(US10597367, Example 60 | US9969726, Example 49A | ...)
Show SMILES c1ccc(cc1)-c1nc(nn1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H19N3/c1-4-11-20(12-5-1)22-15-10-16-23(19-22)25-27-26(21-13-6-2-7-14-21)29(28-25)24-17-8-3-9-18-24/h1-19H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393761
PNG
(US10597367, Example 50 | US9969726, Example 50)
Show SMILES Cn1nc(nc1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17N3/c1-24-21(17-11-6-3-7-12-17)22-20(23-24)19-14-8-13-18(15-19)16-9-4-2-5-10-16/h2-15H,1H3
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n/an/an/an/a 1.48E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393762
PNG
(US10597367, Example 51 | US9969726, Example 51)
Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-16-14-19(15-17-23)21-10-7-11-22(18-21)25-28-26(20-8-3-1-4-9-20)30(29-25)24-12-5-2-6-13-24/h1-18H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393762
PNG
(US10597367, Example 51 | US9969726, Example 51)
Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-16-14-19(15-17-23)21-10-7-11-22(18-21)25-28-26(20-8-3-1-4-9-20)30(29-25)24-12-5-2-6-13-24/h1-18H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393762
PNG
(US10597367, Example 51 | US9969726, Example 51)
Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-16-14-19(15-17-23)21-10-7-11-22(18-21)25-28-26(20-8-3-1-4-9-20)30(29-25)24-12-5-2-6-13-24/h1-18H
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n/an/an/an/a 5.80E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393765
PNG
(US10597367, Example 54 | US9969726, Example 54)
Show SMILES C(c1ccccc1)n1nc(nc1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N3/c1-4-11-21(12-5-1)20-30-27(23-15-8-3-9-16-23)28-26(29-30)25-18-10-17-24(19-25)22-13-6-2-7-14-22/h1-19H,20H2
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393765
PNG
(US10597367, Example 54 | US9969726, Example 54)
Show SMILES C(c1ccccc1)n1nc(nc1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N3/c1-4-11-21(12-5-1)20-30-27(23-15-8-3-9-16-23)28-26(29-30)25-18-10-17-24(19-25)22-13-6-2-7-14-22/h1-19H,20H2
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n/an/an/an/a 2.71E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393768
PNG
(US10597367, Example 57 | US9969726, Example 57)
Show SMILES c1ccc(cc1)-c1nc(nn1-c1cccc2ccccc12)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C30H21N3/c1-3-11-22(12-4-1)25-17-9-18-26(21-25)29-31-30(24-14-5-2-6-15-24)33(32-29)28-20-10-16-23-13-7-8-19-27(23)28/h1-21H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393769
PNG
(US10597367, Example 58 | US9969726, Example 58)
Show SMILES FC(F)(F)c1ccc(cn1)-c1nc(nn1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H17F3N4/c27-26(28,29)23-15-14-21(17-30-23)25-31-24(32-33(25)22-12-5-2-6-13-22)20-11-7-10-19(16-20)18-8-3-1-4-9-18/h1-17H
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393760
PNG
(US10597367, Example 60 | US9969726, Example 49A | ...)
Show SMILES c1ccc(cc1)-c1nc(nn1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H19N3/c1-4-11-20(12-5-1)22-15-10-16-23(19-22)25-27-26(21-13-6-2-7-14-21)29(28-25)24-17-8-3-9-18-24/h1-19H
PDB
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n/an/an/an/a 1.97E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393773
PNG
(US10597367, Example 62 | US9969726, Example 62)
Show SMILES c1coc(c1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C24H17N3O/c1-3-9-18(10-4-1)24-25-23(26-27(24)21-13-5-2-6-14-21)20-12-7-11-19(17-20)22-15-8-16-28-22/h1-17H
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393773
PNG
(US10597367, Example 62 | US9969726, Example 62)
Show SMILES c1coc(c1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C24H17N3O/c1-3-9-18(10-4-1)24-25-23(26-27(24)21-13-5-2-6-14-21)20-12-7-11-19(17-20)22-15-8-16-28-22/h1-17H
PDB

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n/an/an/an/a>3.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393778
PNG
(US10597367, Example 67 | US9969726, Example 67)
Show SMILES OC(=O)c1cccc(c1)-c1cccc(c1)-c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C28H20N2O2/c31-28(32)24-14-8-12-22(18-24)21-11-7-13-23(17-21)26-19-30(25-15-5-2-6-16-25)27(29-26)20-9-3-1-4-10-20/h1-19H,(H,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393784
PNG
(US10597367, Example 73 | US9969726, Example 73)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12F7N3O2/c25-17-6-4-13(9-16(17)22(35)36)12-2-1-3-14(8-12)21-33-18(10-20(34-21)24(29,30)31)15-5-7-19(32-11-15)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 1.18E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393791
PNG
(US10597367, Example 80 | US9969726, Example 80)
Show SMILES OC(=O)c1ccc(s1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C22H11F6N3O2S/c23-21(24,25)17-7-4-13(10-29-17)14-9-18(22(26,27)28)31-19(30-14)12-3-1-2-11(8-12)15-5-6-16(34-15)20(32)33/h1-10H,(H,32,33)
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n/an/an/an/a 2.40E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393792
PNG
(US10597367, Example 81 | US9969726, Example 81)
Show SMILES OC(=O)c1ccc(cc1)-c1ccc(cc1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H13F6N3O2/c25-23(26,27)19-10-9-17(12-31-19)18-11-20(24(28,29)30)33-21(32-18)15-5-1-13(2-6-15)14-3-7-16(8-4-14)22(34)35/h1-12H,(H,34,35)
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n/an/an/an/a 440n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393794
PNG
(US10597367, Example 83 | US9969726, Example 83)
Show SMILES OC(=O)c1cc(ccc1Cl)-c1ccc(cc1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12ClF6N3O2/c25-17-7-5-14(9-16(17)22(35)36)12-1-3-13(4-2-12)21-33-18(10-20(34-21)24(29,30)31)15-6-8-19(32-11-15)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 2.95E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393794
PNG
(US10597367, Example 83 | US9969726, Example 83)
Show SMILES OC(=O)c1cc(ccc1Cl)-c1ccc(cc1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12ClF6N3O2/c25-17-7-5-14(9-16(17)22(35)36)12-1-3-13(4-2-12)21-33-18(10-20(34-21)24(29,30)31)15-6-8-19(32-11-15)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 6.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393796
PNG
(US10597367, Example 85 | US9969726, Example 85)
Show SMILES CNC(=O)c1cc(ccc1Cl)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H15ClF6N4O/c1-33-23(37)17-10-14(5-7-18(17)26)13-3-2-4-15(9-13)22-35-19(11-21(36-22)25(30,31)32)16-6-8-20(34-12-16)24(27,28)29/h2-12H,1H3,(H,33,37)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393800
PNG
(US10597367, Example 88 | US9969726, Example 88)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1
Show InChI InChI=1S/C22H12F4N2O3/c23-16-7-6-13(10-15(16)21(29)30)12-3-1-4-14(9-12)20-27-17(18-5-2-8-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)
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n/an/an/an/a 680n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393802
PNG
(US10597367, Example 90 | US9969726, Example 90)
Show SMILES COc1ccc(cc1C(O)=O)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1
Show InChI InChI=1S/C23H15F3N2O4/c1-31-18-8-7-14(11-16(18)22(29)30)13-4-2-5-15(10-13)21-27-17(19-6-3-9-32-19)12-20(28-21)23(24,25)26/h2-12H,1H3,(H,29,30)
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n/an/an/an/a 3.68E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393802
PNG
(US10597367, Example 90 | US9969726, Example 90)
Show SMILES COc1ccc(cc1C(O)=O)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1
Show InChI InChI=1S/C23H15F3N2O4/c1-31-18-8-7-14(11-16(18)22(29)30)13-4-2-5-15(10-13)21-27-17(19-6-3-9-32-19)12-20(28-21)23(24,25)26/h2-12H,1H3,(H,29,30)
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393805
PNG
(US10597367, Example 93 | US9969726, Example 93)
Show SMILES Cc1cc(C)cc(c1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C26H18F4N2O2/c1-14-8-15(2)10-19(9-14)22-13-23(26(28,29)30)32-24(31-22)18-5-3-4-16(11-18)17-6-7-21(27)20(12-17)25(33)34/h3-13H,1-2H3,(H,33,34)
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393808
PNG
(US10597367, Example 96 | US9969726, Example 96)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C28H22F4N2O2/c1-27(2,3)20-10-7-16(8-11-20)23-15-24(28(30,31)32)34-25(33-23)19-6-4-5-17(13-19)18-9-12-22(29)21(14-18)26(35)36/h4-15H,1-3H3,(H,35,36)
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n/an/an/an/a 5.38E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393808
PNG
(US10597367, Example 96 | US9969726, Example 96)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C28H22F4N2O2/c1-27(2,3)20-10-7-16(8-11-20)23-15-24(28(30,31)32)34-25(33-23)19-6-4-5-17(13-19)18-9-12-22(29)21(14-18)26(35)36/h4-15H,1-3H3,(H,35,36)
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n/an/an/an/a 6.11E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393808
PNG
(US10597367, Example 96 | US9969726, Example 96)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C28H22F4N2O2/c1-27(2,3)20-10-7-16(8-11-20)23-15-24(28(30,31)32)34-25(33-23)19-6-4-5-17(13-19)18-9-12-22(29)21(14-18)26(35)36/h4-15H,1-3H3,(H,35,36)
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n/an/an/an/a 1.52E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393813
PNG
(US10597367, Example 101 | US9969726, Example 101)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc2ccccc2o1
Show InChI InChI=1S/C26H14F4N2O3/c27-19-9-8-15(11-18(19)25(33)34)14-5-3-6-17(10-14)24-31-20(13-23(32-24)26(28,29)30)22-12-16-4-1-2-7-21(16)35-22/h1-13H,(H,33,34)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393813
PNG
(US10597367, Example 101 | US9969726, Example 101)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc2ccccc2o1
Show InChI InChI=1S/C26H14F4N2O3/c27-19-9-8-15(11-18(19)25(33)34)14-5-3-6-17(10-14)24-31-20(13-23(32-24)26(28,29)30)22-12-16-4-1-2-7-21(16)35-22/h1-13H,(H,33,34)
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n/an/an/an/a 950n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393817
PNG
(US10597367, Example 105 | US9969726, Example 105)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393824
PNG
(US10597367, Example 112 | US9969726, Example 112)
Show SMILES Cc1ccc(s1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C23H14F4N2O2S/c1-12-5-8-19(32-12)18-11-20(23(25,26)27)29-21(28-18)15-4-2-3-13(9-15)14-6-7-17(24)16(10-14)22(30)31/h2-11H,1H3,(H,30,31)
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n/an/an/an/a 1.61E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393826
PNG
(US10597367, Example 114 | US9969726, Example 114)
Show SMILES OC(=O)c1ccc(F)c(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1
Show InChI InChI=1S/C22H12F4N2O3/c23-17-5-4-14(21(29)30)9-16(17)12-2-1-3-13(8-12)20-27-18(15-6-7-31-11-15)10-19(28-20)22(24,25)26/h1-11H,(H,29,30)
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n/an/an/an/a 140n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393827
PNG
(US10597367, Example 115 | US9969726, Example 115)
Show SMILES OC(=O)c1cccc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1
Show InChI InChI=1S/C22H13F3N2O3/c23-22(24,25)19-11-18(17-7-8-30-12-17)26-20(27-19)15-5-1-3-13(9-15)14-4-2-6-16(10-14)21(28)29/h1-12H,(H,28,29)
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n/an/an/an/a 120n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393827
PNG
(US10597367, Example 115 | US9969726, Example 115)
Show SMILES OC(=O)c1cccc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1
Show InChI InChI=1S/C22H13F3N2O3/c23-22(24,25)19-11-18(17-7-8-30-12-17)26-20(27-19)15-5-1-3-13(9-15)14-4-2-6-16(10-14)21(28)29/h1-12H,(H,28,29)
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n/an/an/an/a 450n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393831
PNG
(US10597367, Example 119 | US9969726, Example 119)
Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1
Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)
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n/an/an/an/a 50n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393831
PNG
(US10597367, Example 119 | US9969726, Example 119)
Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1
Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)
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n/an/an/an/a 350n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM438128
PNG
(US10597367, Example 121)
Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cc(F)cc(c1)C(O)=O)-c1ccoc1
Show InChI InChI=1S/C22H15FN2O3/c1-13-7-20(16-5-6-28-12-16)25-21(24-13)15-4-2-3-14(8-15)17-9-18(22(26)27)11-19(23)10-17/h2-12H,1H3,(H,26,27)
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n/an/an/an/a 310n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM438128
PNG
(US10597367, Example 121)
Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cc(F)cc(c1)C(O)=O)-c1ccoc1
Show InChI InChI=1S/C22H15FN2O3/c1-13-7-20(16-5-6-28-12-16)25-21(24-13)15-4-2-3-14(8-15)17-9-18(22(26)27)11-19(23)10-17/h2-12H,1H3,(H,26,27)
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n/an/an/an/a 2.21E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Rattus norvegicus)
BDBM393835
PNG
(US10597367, Example 123 | US9969726, Example 123)
Show SMILES FC(F)(F)c1ccc(cn1)-c1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)-c1nn[nH]n1)C(F)(F)F
Show InChI InChI=1S/C24H13F6N7/c25-23(26,27)19-8-7-17(12-31-19)18-11-20(24(28,29)30)33-21(32-18)15-5-1-3-13(9-15)14-4-2-6-16(10-14)22-34-36-37-35-22/h1-12H,(H,34,35,36,37)
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n/an/an/an/a 750n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393839
PNG
(US10597367, Example 127 | US9969726, Example 127)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(Nc2nc(cc(n2)C(F)(F)F)-c2ccco2)c1
Show InChI InChI=1S/C22H13F4N3O3/c23-16-7-6-13(10-15(16)20(30)31)12-3-1-4-14(9-12)27-21-28-17(18-5-2-8-32-18)11-19(29-21)22(24,25)26/h1-11H,(H,30,31)(H,27,28,29)
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n/an/an/an/a 3.14E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393840
PNG
(US10597367, Example 128 | US9969726, Example 128)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(Oc2nc(cc(n2)C(F)(F)F)-c2ccco2)c1
Show InChI InChI=1S/C22H12F4N2O4/c23-16-7-6-13(10-15(16)20(29)30)12-3-1-4-14(9-12)32-21-27-17(18-5-2-8-31-18)11-19(28-21)22(24,25)26/h1-11H,(H,29,30)
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n/an/an/an/a>3.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10597367 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%