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Patent code US10597377

Compile Data Set for Download or QSAR

Found 268 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405572
PNG
(US10351547, Compound 1-20 | US10597377, Compound 1...)
Show SMILES NC1CCN(CC1)c1c(nnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H21F2N5O/c27-18-10-17(11-19(28)13-18)24-25(33-8-6-20(30)7-9-33)22-12-15(4-5-23(22)31-32-24)21-3-1-2-16(14-29)26(21)34/h1-5,10-13,20,34H,6-9,30H2
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405584
PNG
(US10351547, Compound 1-32 | US10597377, Compound 1...)
Show SMILES NC(=O)c1cc(F)cc(c1)-c1ccc2nnc(-c3cc(Cl)cc(Cl)c3)c(N3CCC(CC3)NCCC(F)(F)F)c2c1
Show InChI InChI=1S/C29H25Cl2F4N5O/c30-20-10-18(11-21(31)15-20)26-27(40-7-3-23(4-8-40)37-6-5-29(33,34)35)24-14-16(1-2-25(24)38-39-26)17-9-19(28(36)41)13-22(32)12-17/h1-2,9-15,23,37H,3-8H2,(H2,36,41)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405585
PNG
(US10351547, Compound 1-33 | US10597377, Compound 1...)
Show SMILES NC(=O)c1cc(F)cc(c1)-c1ccc2nnc(-c3cc(Cl)cc(Cl)c3)c(N3CCC(CC3)NCCF)c2c1
Show InChI InChI=1S/C28H25Cl2F2N5O/c29-20-10-18(11-21(30)15-20)26-27(37-7-3-23(4-8-37)34-6-5-31)24-14-16(1-2-25(24)35-36-26)17-9-19(28(33)38)13-22(32)12-17/h1-2,9-15,23,34H,3-8H2,(H2,33,38)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405592
PNG
(US10351547, Compound 2-6 | US10597377, Compound 2-...)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1ccccc1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H23F2N3O/c27-18-11-17(12-19(28)14-18)23-15-30-24-6-5-16(21-3-1-2-4-25(21)32)13-22(24)26(23)31-9-7-20(29)8-10-31/h1-6,11-15,20,32H,7-10,29H2
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405599
PNG
(US10351547, Compound 2-13 | US10597377, Compound 2...)
Show SMILES Cc1cc(Cl)cc(c1)-c1cnc2ccc(cc2c1N1CC(CN)C1)-c1cccc(C#N)c1O
Show InChI InChI=1S/C27H23ClN4O/c1-16-7-20(9-21(28)8-16)24-13-31-25-6-5-18(22-4-2-3-19(12-30)27(22)33)10-23(25)26(24)32-14-17(11-29)15-32/h2-10,13,17,33H,11,14-15,29H2,1H3
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405601
PNG
(US10351547, Compound 2-15 | US10597377, Compound 2...)
Show SMILES Cc1cc(Cl)cc(c1)-c1cnc2ccc(cc2c1N1CC(C)(CN)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C28H24ClFN4O/c1-16-5-18(7-20(29)6-16)24-12-33-25-4-3-17(22-10-21(30)8-19(11-31)27(22)35)9-23(25)26(24)34-14-28(2,13-32)15-34/h3-10,12,35H,13-15,32H2,1-2H3
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n/an/an/an/a 550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405608
PNG
(US10351547, Compound 2-22 | US10597377, Compound 2...)
Show SMILES Cc1cc(Cl)cc(c1)-c1cnc2ccc(cc2c1N1CC(CN)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C27H22ClFN4O/c1-15-4-18(6-20(28)5-15)24-12-32-25-3-2-17(22-9-21(29)7-19(11-31)27(22)34)8-23(25)26(24)33-13-16(10-30)14-33/h2-9,12,16,34H,10,13-14,30H2,1H3
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405621
PNG
(US10351547, Compound 2-39 | US10597377, Compound 2...)
Show SMILES COCC(C)(C)NCC1CN(C1)c1c(cnc2ccc(cc12)-c1cc(F)cc(C#N)c1O)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C32H32F2N4O2/c1-19-7-22(9-24(33)8-19)28-15-36-29-6-5-21(26-12-25(34)10-23(13-35)31(26)39)11-27(29)30(28)38-16-20(17-38)14-37-32(2,3)18-40-4/h5-12,15,20,37,39H,14,16-18H2,1-4H3
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n/an/an/an/a 550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405624
PNG
(US10351547, Compound 2-42 | US10597377, Compound 2...)
Show SMILES CCCNCC1CN(C1)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C30H29FN4O/c1-3-9-33-15-20-17-35(18-20)29-26-13-21(25-6-4-5-22(14-32)30(25)36)7-8-28(26)34-16-27(29)23-10-19(2)11-24(31)12-23/h4-8,10-13,16,20,33,36H,3,9,15,17-18H2,1-2H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405627
PNG
(US10351547, Compound 2-45 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CNC2CCOC2)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C31H28F2N4O2/c1-18-6-21(8-23(32)7-18)28-14-36-29-3-2-20(26-11-24(33)9-22(12-34)31(26)38)10-27(29)30(28)37-15-19(16-37)13-35-25-4-5-39-17-25/h2-3,6-11,14,19,25,35,38H,4-5,13,15-17H2,1H3
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405635
PNG
(US10351547, Compound 2-53 | US10597377, Compound 2...)
Show SMILES COCOc1c(cc(F)cc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CC(CNCCCO)C3)c2c1)C#N
Show InChI InChI=1S/C32H32F2N4O3/c1-20-8-23(10-25(33)9-20)29-16-37-30-5-4-22(27-13-26(34)11-24(14-35)32(27)41-19-40-2)12-28(30)31(29)38-17-21(18-38)15-36-6-3-7-39/h4-5,8-13,16,21,36,39H,3,6-7,15,17-19H2,1-2H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM438123
PNG
(US10597377, Compound 2-85)
Show SMILES CC(=C)c1cccc(n1)-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CC[C@@H]4NCCO[C@H]4C3)c2c1
Show InChI InChI=1S/C30H28F2N4O/c1-18(2)25-4-3-5-26(35-25)19-6-7-27-23(14-19)30(36-10-8-28-29(17-36)37-11-9-33-28)24(16-34-27)20-12-21(31)15-22(32)13-20/h3-7,12-16,28-29,33H,1,8-11,17H2,2H3/t28-,29-/m0/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405683
PNG
(US10351547, Compound 2-139 | US10597377, Compound ...)
Show SMILES CONC(=O)Nc1c(F)cc(F)cc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C28H25F4N5O2/c1-39-36-28(38)35-26-21(12-19(31)13-24(26)32)15-2-3-25-22(10-15)27(37-6-4-20(33)5-7-37)23(14-34-25)16-8-17(29)11-18(30)9-16/h2-3,8-14,20H,4-7,33H2,1H3,(H2,35,36,38)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405685
PNG
(US10351547, Compound 2-142 | US10597377, Compound ...)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1ccc2oc(=O)[nH]c2c1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H22F2N4O2/c28-18-9-17(10-19(29)13-18)22-14-31-23-3-1-15(16-2-4-25-24(12-16)32-27(34)35-25)11-21(23)26(22)33-7-5-20(30)6-8-33/h1-4,9-14,20H,5-8,30H2,(H,32,34)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405686
PNG
(US10351547, Compound 2-143 | US10351547, Compound ...)
Show SMILES COC(=O)[C@@H]1CN(CC[C@H]1N)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H24F2N4O3/c1-38-29(37)24-15-35(8-7-25(24)33)27-22-11-16(21-4-2-3-17(13-32)28(21)36)5-6-26(22)34-14-23(27)18-9-19(30)12-20(31)10-18/h2-6,9-12,14,24-25,36H,7-8,15,33H2,1H3/t24-,25-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405702
PNG
(US10351547, Compound 2-169 | US10597377, Compound ...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC(N)CC1)-c1cncc(F)c1N
Show InChI InChI=1S/C26H25F2N5/c1-15-8-17(10-18(27)9-15)22-13-32-24-3-2-16(21-12-31-14-23(28)25(21)30)11-20(24)26(22)33-6-4-19(29)5-7-33/h2-3,8-14,19H,4-7,29H2,1H3,(H2,30,31)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405704
PNG
(US10351547, Compound 2-171 | US10597377, Compound ...)
Show SMILES COC(=O)Nc1c(F)cncc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C28H27F2N5O2/c1-16-9-18(11-19(29)10-16)23-14-33-25-4-3-17(12-21(25)27(23)35-7-5-20(31)6-8-35)22-13-32-15-24(30)26(22)34-28(36)37-2/h3-4,9-15,20H,5-8,31H2,1-2H3,(H,32,34,36)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405712
PNG
(US10351547, Compound 2-179 | US10597377, Compound ...)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1c(N)c(cc(F)c1F)C#N)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H21F4N5/c28-17-7-15(8-18(29)11-17)21-13-35-23-2-1-14(24-25(31)22(30)10-16(12-32)26(24)34)9-20(23)27(21)36-5-3-19(33)4-6-36/h1-2,7-11,13,19H,3-6,33-34H2
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405740
PNG
(US10351547, Compound 2-210 | US10597377, Compound ...)
Show SMILES CON(C)C(=O)Nc1c(F)cccc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C30H31F2N5O2/c1-18-13-20(15-21(31)14-18)25-17-34-27-8-7-19(16-24(27)29(25)37-11-9-22(33)10-12-37)23-5-4-6-26(32)28(23)35-30(38)36(2)39-3/h4-8,13-17,22H,9-12,33H2,1-3H3,(H,35,38)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405743
PNG
(US10351547, Compound 2-213 | US10597377, Compound ...)
Show SMILES CON=Cc1cc(ccc1O)-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C29H29FN4O2/c1-18-11-21(14-23(30)12-18)26-17-32-27-5-3-20(19-4-6-28(35)22(13-19)16-33-36-2)15-25(27)29(26)34-9-7-24(31)8-10-34/h3-6,11-17,24,35H,7-10,31H2,1-2H3/b33-16+
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405604
PNG
(US10351547, Compound 2-18 | US10597377, Compound 2...)
Show SMILES CCNCC1CN(C1)c1c(cnc2ccc(cc12)-c1cc(F)cc(C#N)c1O)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C29H26F2N4O/c1-3-33-13-18-15-35(16-18)28-25-10-19(24-11-23(31)9-21(12-32)29(24)36)4-5-27(25)34-14-26(28)20-6-17(2)7-22(30)8-20/h4-11,14,18,33,36H,3,13,15-16H2,1-2H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405762
PNG
(US10351547, Compound 2-232 | US10597377, Compound ...)
Show SMILES COCCOc1c(cc(F)cc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CC[C@H](N)[C@H](O)C3)c2c1)C#N
Show InChI InChI=1S/C30H27F3N4O3/c1-39-6-7-40-30-19(14-34)10-22(33)13-23(30)17-2-3-27-24(11-17)29(37-5-4-26(35)28(38)16-37)25(15-36-27)18-8-20(31)12-21(32)9-18/h2-3,8-13,15,26,28,38H,4-7,16,35H2,1H3/t26-,28+/m0/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405767
PNG
(US10351547, Compound 2-237 | US10597377, Compound ...)
Show SMILES CONC(=O)Nc1c(F)cc(cc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C30H28F2N6O2/c1-17-9-20(13-21(31)10-17)25-16-35-27-4-3-19(14-24(27)29(25)38-7-5-22(34)6-8-38)23-11-18(15-33)12-26(32)28(23)36-30(39)37-40-2/h3-4,9-14,16,22H,5-8,34H2,1-2H3,(H2,36,37,39)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM438240
PNG
(US10597377, Compound 2-245 | US10597377, Compound ...)
Show SMILES Cn1cc(c(N)n1)-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC4NCCO[C@@H]4C3)c2c1
Show InChI InChI=1S/C26H26F2N6O/c1-33-13-21(26(29)32-33)15-2-3-22-19(10-15)25(34-6-4-23-24(14-34)35-7-5-30-23)20(12-31-22)16-8-17(27)11-18(28)9-16/h2-3,8-13,23-24,30H,4-7,14H2,1H3,(H2,29,32)/t23?,24-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM438245
PNG
(US10597377, Compound 2-250)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1ncccc1N)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H23F2N5/c26-17-10-16(11-18(27)13-17)21-14-31-23-4-3-15(24-22(29)2-1-7-30-24)12-20(23)25(21)32-8-5-19(28)6-9-32/h1-4,7,10-14,19H,5-6,8-9,28-29H2
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM438248
PNG
(US10597377, Compound 2-253)
Show SMILES Cn1ncc(c1\C=C\O)-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC4NCCO[C@@H]4C3)c2c1
Show InChI InChI=1S/C28H27F2N5O2/c1-34-26(5-8-36)22(15-33-34)17-2-3-24-21(12-17)28(35-7-4-25-27(16-35)37-9-6-31-25)23(14-32-24)18-10-19(29)13-20(30)11-18/h2-3,5,8,10-15,25,27,31,36H,4,6-7,9,16H2,1H3/b8-5+/t25?,27-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM438256
PNG
(US10597377, Compound 2-261)
Show SMILES Fc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC2NCCO[C@@H]2C1)-c1ncc(cc1F)C#[F]
Show InChI InChI=1S/C28H22F4N4O/c29-12-16-7-23(32)27(35-13-16)17-1-2-24-21(10-17)28(36-5-3-25-26(15-36)37-6-4-33-25)22(14-34-24)18-8-19(30)11-20(31)9-18/h1-2,7-11,13-14,25-26,33H,3-6,15H2/t25?,26-/m1/s1
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405800
PNG
(US10351547, Compound 2-270 | US10597377, Compound ...)
Show SMILES Oc1c(cccc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CC(C3)C3COCCN3)c2c1)C#N
Show InChI InChI=1S/C29H24F2N4O2/c30-21-8-19(9-22(31)11-21)25-13-34-26-5-4-17(23-3-1-2-18(12-32)29(23)36)10-24(26)28(25)35-14-20(15-35)27-16-37-7-6-33-27/h1-5,8-11,13,20,27,33,36H,6-7,14-16H2
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405805
PNG
(US10351547, Compound 2-275 | US10597377, Compound ...)
Show SMILES Nc1c(Cl)ccnc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CC[C@H]4OCCN[C@@H]4C3)c2c1
Show InChI InChI=1S/C27H24ClF2N5O/c28-21-3-5-33-26(25(21)31)15-1-2-22-19(11-15)27(35-7-4-24-23(14-35)32-6-8-36-24)20(13-34-22)16-9-17(29)12-18(30)10-16/h1-3,5,9-13,23-24,32H,4,6-8,14,31H2/t23-,24-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405818
PNG
(US10351547, Compound 4-3 | US10597377, Compound 4-...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ncc(cc2c1N1CCC(N)CC1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C27H23F2N5O/c1-15-6-16(8-19(28)7-15)24-14-33-27-23(25(24)34-4-2-21(31)3-5-34)10-18(13-32-27)22-11-20(29)9-17(12-30)26(22)35/h6-11,13-14,21,35H,2-5,31H2,1H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405557
PNG
(US10351547, Compound 1-5 | US10597377, Compound 1-...)
Show SMILES Cc1cc(F)cc(c1)-c1nnc2cc(Cl)c(cc2c1N1CC[C@@H](N)[C@H](F)C1)-c1cc(F)cc(c1)C(N)=O
Show InChI InChI=1S/C27H23ClF3N5O/c1-13-4-15(8-17(29)5-13)25-26(36-3-2-23(32)22(31)12-36)20-10-19(21(28)11-24(20)34-35-25)14-6-16(27(33)37)9-18(30)7-14/h4-11,22-23H,2-3,12,32H2,1H3,(H2,33,37)/t22-,23-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405573
PNG
(US10351547, Compound 1-21 | US10597377, Compound 1...)
Show SMILES NC1CCN(CC1)c1c(nnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H21Cl2N5O/c27-18-10-17(11-19(28)13-18)24-25(33-8-6-20(30)7-9-33)22-12-15(4-5-23(22)31-32-24)21-3-1-2-16(14-29)26(21)34/h1-5,10-13,20,34H,6-9,30H2
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM437820
PNG
(US10597377, Compound 1-24)
Show SMILES Cc1cc(C)cc(c1)-c1nnc2ccc(cc2c1N1CCC(N)CC1)-c1cc(F)cc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C28H27FN6O/c1-15-9-16(2)11-18(10-15)25-27(35-7-5-20(30)6-8-35)22-12-17(3-4-23(22)33-34-25)21-13-19(29)14-24-26(21)32-28(36)31-24/h3-4,9-14,20H,5-8,30H2,1-2H3,(H2,31,32,36)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405588
PNG
(US10351547, Compound 2-2 | US10464918, Compound A ...)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405607
PNG
(US10351547, Compound 2-21 | US10597377, Compound 2...)
Show SMILES NCC1CN(C1)c1c(cnc2ccc(cc12)-c1cc(F)cc(C#N)c1O)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C26H19ClF2N4O/c27-18-3-16(4-19(28)7-18)23-11-32-24-2-1-15(21-8-20(29)5-17(10-31)26(21)34)6-22(24)25(23)33-12-14(9-30)13-33/h1-8,11,14,34H,9,12-13,30H2
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM437996
PNG
(US10597377, Compound 2-29 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CNC2CC2)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C30H26F2N4O/c1-17-6-20(8-22(31)7-17)27-14-35-28-5-2-19(25-11-23(32)9-21(12-33)30(25)37)10-26(28)29(27)36-15-18(16-36)13-34-24-3-4-24/h2,5-11,14,18,24,34,37H,3-4,13,15-16H2,1H3
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405618
PNG
(US10351547, Compound 2-33 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CNC2COC2)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C30H26F2N4O2/c1-17-4-20(6-22(31)5-17)27-12-35-28-3-2-19(25-9-23(32)7-21(10-33)30(25)37)8-26(28)29(27)36-13-18(14-36)11-34-24-15-38-16-24/h2-9,12,18,24,34,37H,11,13-16H2,1H3
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405625
PNG
(US10351547, Compound 2-43 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CNCCO)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C29H26F2N4O2/c1-17-6-20(8-22(30)7-17)26-14-34-27-3-2-19(24-11-23(31)9-21(12-32)29(24)37)10-25(27)28(26)35-15-18(16-35)13-33-4-5-36/h2-3,6-11,14,18,33,36-37H,4-5,13,15-16H2,1H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405626
PNG
(US10351547, Compound 2-44 | US10597377, Compound 2...)
Show SMILES CCN(CCO)CC1CN(C1)c1c(cnc2ccc(cc12)-c1cc(F)cc(C#N)c1O)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C31H30F2N4O2/c1-3-36(6-7-38)16-20-17-37(18-20)30-27-12-21(26-13-25(33)11-23(14-34)31(26)39)4-5-29(27)35-15-28(30)22-8-19(2)9-24(32)10-22/h4-5,8-13,15,20,38-39H,3,6-7,16-18H2,1-2H3
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n/an/an/an/a 550n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405630
PNG
(US10351547, Compound 2-48 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CN2CC[C@@H](F)C2)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C31H27F3N4O/c1-18-6-21(8-24(33)7-18)28-13-36-29-3-2-20(26-11-25(34)9-22(12-35)31(26)39)10-27(29)30(28)38-15-19(16-38)14-37-5-4-23(32)17-37/h2-3,6-11,13,19,23,39H,4-5,14-17H2,1H3/t23-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405631
PNG
(US10351547, Compound 2-49 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CN2CC[C@H](F)C2)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C31H27F3N4O/c1-18-6-21(8-24(33)7-18)28-13-36-29-3-2-20(26-11-25(34)9-22(12-35)31(26)39)10-27(29)30(28)38-15-19(16-38)14-37-5-4-23(32)17-37/h2-3,6-11,13,19,23,39H,4-5,14-17H2,1H3/t23-/m0/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405634
PNG
(US10351547, Compound 2-52 | US10597377, Compound 2...)
Show SMILES CCCNCC1CN(C1)c1c(cnc2ccc(cc12)-c1cc(F)c(O)c(F)c1)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C29H28F3N3O/c1-3-6-33-13-18-15-35(16-18)28-23-10-19(20-11-25(31)29(36)26(32)12-20)4-5-27(23)34-14-24(28)21-7-17(2)8-22(30)9-21/h4-5,7-12,14,18,33,36H,3,6,13,15-16H2,1-2H3
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405640
PNG
(US10351547, Compound 2-58 | US10597377, Compound 2...)
Show SMILES COCOc1c(cccc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CC[C@H](N)[C@H](O)C3)c2c1)C#N
Show InChI InChI=1S/C29H26F2N4O3/c1-37-16-38-29-18(13-32)3-2-4-22(29)17-5-6-26-23(11-17)28(35-8-7-25(33)27(36)15-35)24(14-34-26)19-9-20(30)12-21(31)10-19/h2-6,9-12,14,25,27,36H,7-8,15-16,33H2,1H3/t25-,27+/m0/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405643
PNG
(US10351547, Compound 2-61 | US10597377, Compound 2...)
Show SMILES CO[C@H]1CN(CC[C@H]1N)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C28H24F2N4O2/c1-36-26-15-34(8-7-24(26)32)27-22-11-16(21-4-2-3-17(13-31)28(21)35)5-6-25(22)33-14-23(27)18-9-19(29)12-20(30)10-18/h2-6,9-12,14,24,26,35H,7-8,15,32H2,1H3/t24-,26+/m1/s1
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405649
PNG
(US10351547, Compound 2-67 | US10597377, Compound 2...)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cccc(C(N)=O)c1OC(CO)CO)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C30H30F2N4O4/c31-19-10-18(11-20(32)13-19)26-14-35-27-5-4-17(12-25(27)28(26)36-8-6-21(33)7-9-36)23-2-1-3-24(30(34)39)29(23)40-22(15-37)16-38/h1-5,10-14,21-22,37-38H,6-9,15-16,33H2,(H2,34,39)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405650
PNG
(US10351547, Compound 2-68 | US10597377, Compound 2...)
Show SMILES COCCOc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC(N)CC1)-c1cccc(C#N)c1O
Show InChI InChI=1S/C30H29FN4O3/c1-37-11-12-38-24-14-21(13-22(31)16-24)27-18-34-28-6-5-19(25-4-2-3-20(17-32)30(25)36)15-26(28)29(27)35-9-7-23(33)8-10-35/h2-6,13-16,18,23,36H,7-12,33H2,1H3
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405654
PNG
(US10351547, Compound 2-72 | US10597377, Compound 2...)
Show SMILES COCCOc1c(cccc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C30H28F2N4O2/c1-37-11-12-38-30-20(17-33)3-2-4-25(30)19-5-6-28-26(15-19)29(36-9-7-24(34)8-10-36)27(18-35-28)21-13-22(31)16-23(32)14-21/h2-6,13-16,18,24H,7-12,34H2,1H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405670
PNG
(US10351547, Compound 2-88 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC(N)CC1)-c1cccc(C(=O)N2CCC2)c1O
Show InChI InChI=1S/C31H31FN4O2/c1-19-14-21(16-22(32)15-19)27-18-34-28-7-6-20(17-26(28)29(27)35-12-8-23(33)9-13-35)24-4-2-5-25(30(24)37)31(38)36-10-3-11-36/h2,4-7,14-18,23,37H,3,8-13,33H2,1H3
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM438139
PNG
(US10597377, Compound 2-134)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1c(O)c(Cl)cc(F)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C26H21ClF3N3O/c27-20-12-21(29)24(30)23(26(20)34)15-4-5-22-18(11-15)25(33-8-6-17(31)7-9-33)19(13-32-22)14-2-1-3-16(28)10-14/h1-5,10-13,17,34H,6-9,31H2
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405709
PNG
(US10351547, Compound 2-176 | US10597377, Compound ...)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cncc(F)c1C=NO)-c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H22F5N5O/c28-18-8-16(7-17(10-18)27(30,31)32)22-12-35-25-2-1-15(21-11-34-14-24(29)23(21)13-36-38)9-20(25)26(22)37-5-3-19(33)4-6-37/h1-2,7-14,19,38H,3-6,33H2/b36-13+
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...


US Patent US10597377 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%