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Patent code US10604502

Compile Data Set for Download or QSAR
Found 112 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439100
PNG
(US10604502, Ex # 88)
Show SMILES Cc1cc2n(cc(-c3cncc4NC(C)(C)C=Cc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H28N4O/c1-16-10-25-21(11-17(16)12-27)23(15-30(25)18-4-6-19(31)7-5-18)22-13-28-14-24-20(22)8-9-26(2,3)29-24/h8-11,13-15,18-19,29,31H,4-7H2,1-3H3/t18-,19-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439120
PNG
(US10604502, Ex # 108)
Show SMILES CN(C)S(=O)(=O)[C@H]1CC[C@@H](CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C23H26ClN5O2S/c1-14-8-22-18(9-15(14)10-25)20(19-11-27-12-21(26)23(19)24)13-29(22)16-4-6-17(7-5-16)32(30,31)28(2)3/h8-9,11-13,16-17H,4-7,26H2,1-3H3/t16-,17-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439089
PNG
(US10604502, Ex # 77)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H17ClN4O2S/c1-13-7-21-17(8-14(13)9-24)19(18-10-26-11-20(25)22(18)23)12-27(21)15-3-5-16(6-4-15)30(2,28)29/h3-8,10-12H,25H2,1-2H3
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439014
PNG
(US10604502, Ex # 2)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C21H21ClN4O/c1-12-6-20-16(7-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-2-4-15(27)5-3-14/h6-7,9-11,14-15,27H,2-5,24H2,1H3/t14-,15+
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439039
PNG
(US10604502, Ex # 27)
Show SMILES Cc1cc2n(cc(-c3c(C)c(N)ccc3F)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C23H24FN3O/c1-13-9-22-18(10-15(13)11-25)19(23-14(2)21(26)8-7-20(23)24)12-27(22)16-3-5-17(28)6-4-16/h7-10,12,16-17,28H,3-6,26H2,1-2H3/t16-,17+
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439109
PNG
(3-(2,2-dimethyl-1,2,3,4-tetrahydroquinolin-5-yl)-1...)
Show SMILES Cc1cc2n(cc(-c3cccc4NC(C)(C)CCc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H31N3O/c1-17-13-26-23(14-18(17)15-28)24(16-30(26)19-7-9-20(31)10-8-19)21-5-4-6-25-22(21)11-12-27(2,3)29-25/h4-6,13-14,16,19-20,29,31H,7-12H2,1-3H3/t19-,20-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439101
PNG
(3-(2,2-dimethyl-1,2,3,4-tetrahydro-1,7-naphthyridi...)
Show SMILES Cc1cc2n(cc(-c3cncc4NC(C)(C)CCc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H30N4O/c1-16-10-25-21(11-17(16)12-27)23(15-30(25)18-4-6-19(31)7-5-18)22-13-28-14-24-20(22)8-9-26(2,3)29-24/h10-11,13-15,18-19,29,31H,4-9H2,1-3H3/t18-,19-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439046
PNG
(US10604502, Ex # 34)
Show SMILES Cc1cc2n(CCCO)cc(-c3cccc4NC(C)(C)CCc34)c2cc1C#N
Show InChI InChI=1S/C24H27N3O/c1-16-12-23-20(13-17(16)14-25)21(15-27(23)10-5-11-28)18-6-4-7-22-19(18)8-9-24(2,3)26-22/h4,6-7,12-13,15,26,28H,5,8-11H2,1-3H3
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439056
PNG
(US10604502, Ex # 44)
Show SMILES COC(=O)[C@H]1CC[C@@H](CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C23H23ClN4O2/c1-13-7-21-17(8-15(13)9-25)19(18-10-27-11-20(26)22(18)24)12-28(21)16-5-3-14(4-6-16)23(29)30-2/h7-8,10-12,14,16H,3-6,26H2,1-2H3/t14-,16-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439107
PNG
(US10604502, Ex # 95)
Show SMILES Cc1cc2n(cc(-c3cccc4NC(C)(C)C=Cc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H29N3O/c1-17-13-26-23(14-18(17)15-28)24(16-30(26)19-7-9-20(31)10-8-19)21-5-4-6-25-22(21)11-12-27(2,3)29-25/h4-6,11-14,16,19-20,29,31H,7-10H2,1-3H3/t19-,20-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439121
PNG
(1-((1R,4R)-1-aminosulfonylcyclohexyl)-6-methyl-3-(...)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@@H](CC1)S(N)(=O)=O
Show InChI InChI=1S/C21H22ClN5O2S/c1-12-6-20-16(7-13(12)8-23)18(17-9-26-10-19(24)21(17)22)11-27(20)14-2-4-15(5-3-14)30(25,28)29/h6-7,9-11,14-15H,2-5,24H2,1H3,(H2,25,28,29)/t14-,15-
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US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439090
PNG
(US10604502, Ex # 78)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc(nc1)S(C)(=O)=O
Show InChI InChI=1S/C21H16ClN5O2S/c1-12-5-19-15(6-13(12)7-23)17(16-9-25-10-18(24)21(16)22)11-27(19)14-3-4-20(26-8-14)30(2,28)29/h3-6,8-11H,24H2,1-2H3
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439036
PNG
(3-(3-amino-2-methylphenyl)-1-(3-hydroxypropyl)-2,6...)
Show SMILES Cc1c(-c2cccc(N)c2C)c2cc(C#N)c(C)cc2n1CCCO
Show InChI InChI=1S/C21H23N3O/c1-13-10-20-18(11-16(13)12-22)21(15(3)24(20)8-5-9-25)17-6-4-7-19(23)14(17)2/h4,6-7,10-11,25H,5,8-9,23H2,1-3H3
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439015
PNG
(US10604502, Ex # 3)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3C(F)F)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H22F2N4O/c1-12-6-20-16(7-13(12)8-25)18(11-28(20)14-2-4-15(29)5-3-14)17-9-27-10-19(26)21(17)22(23)24/h6-7,9-11,14-15,22,29H,2-5,26H2,1H3/t14-,15-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439024
PNG
(US10604502, Ex # 12)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@H](O)C1
Show InChI InChI=1S/C20H19ClN4O/c1-11-4-19-15(5-12(11)7-22)17(16-8-24-9-18(23)20(16)21)10-25(19)13-2-3-14(26)6-13/h4-5,8-10,13-14,26H,2-3,6,23H2,1H3/t13-,14+/m1/s1
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439091
PNG
(US10604502, Ex # 79)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C21H16ClN5O2S/c1-12-6-20-16(7-13(12)8-23)18(17-9-26-10-19(24)21(17)22)11-27(20)14-2-4-15(5-3-14)30(25,28)29/h2-7,9-11H,24H2,1H3,(H2,25,28,29)
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439122
PNG
(US10604502, Ex # 110)
Show SMILES CC(=O)[C@H]1CC[C@@H](CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C23H23ClN4O/c1-13-7-22-18(8-16(13)9-25)20(19-10-27-11-21(26)23(19)24)12-28(22)17-5-3-15(4-6-17)14(2)29/h7-8,10-12,15,17H,3-6,26H2,1-2H3/t15-,17-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439021
PNG
(US10604502, Ex # 9)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CCC[C@@H](O)C1
Show InChI InChI=1S/C21H21ClN4O/c1-12-5-20-16(6-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-3-2-4-15(27)7-14/h5-6,9-11,14-15,27H,2-4,7,24H2,1H3/t14-,15-/m1/s1
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439059
PNG
(US10604502, Ex # 47)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@@H](CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H23ClN4O2S/c1-13-7-21-17(8-14(13)9-24)19(18-10-26-11-20(25)22(18)23)12-27(21)15-3-5-16(6-4-15)30(2,28)29/h7-8,10-12,15-16H,3-6,25H2,1-2H3/t15-,16-
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439124
PNG
(1-((1R,4R)-4-cyanocyclohexyl)-6-methyl-3-(5-amino-...)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@@H](CC1)C#N
Show InChI InChI=1S/C22H20ClN5/c1-13-6-21-17(7-15(13)9-25)19(18-10-27-11-20(26)22(18)23)12-28(21)16-4-2-14(8-24)3-5-16/h6-7,10-12,14,16H,2-5,26H2,1H3/t14-,16-
PDB
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439123
PNG
(US10604502, Ex # 111)
Show SMILES CC(=O)[C@H]1CC[C@H](CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C23H23ClN4O/c1-13-7-22-18(8-16(13)9-25)20(19-10-27-11-21(26)23(19)24)12-28(22)17-5-3-15(4-6-17)14(2)29/h7-8,10-12,15,17H,3-6,26H2,1-2H3/t15-,17+
PDB
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Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439108
PNG
(US10604502, Ex # 96)
Show SMILES Cc1cc2n(cc(-c3cccc4NC(C)(C)C=Cc34)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H29N3O/c1-17-13-26-23(14-18(17)15-28)24(16-30(26)19-7-9-20(31)10-8-19)21-5-4-6-25-22(21)11-12-27(2,3)29-25/h4-6,11-14,16,19-20,29,31H,7-10H2,1-3H3/t19-,20+
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n/an/a 9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439079
PNG
(US10604502, Ex # 67)
Show SMILES COC(=O)C1CCC(C1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C22H21ClN4O2/c1-12-5-20-16(7-14(12)8-24)18(17-9-26-10-19(25)21(17)23)11-27(20)15-4-3-13(6-15)22(28)29-2/h5,7,9-11,13,15H,3-4,6,25H2,1-2H3
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n/an/a 9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439092
PNG
(3-(5-amino-4-chloropyridin-3-yl)-6-methyl-1-(5-(me...)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C21H16ClN5O2S/c1-12-5-19-15(6-13(12)7-23)17(16-9-25-10-18(24)21(16)22)11-27(19)20-4-3-14(8-26-20)30(2,28)29/h3-6,8-11H,24H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439013
PNG
(US10604502, Ex # 1)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C21H21ClN4O/c1-12-6-20-16(7-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-2-4-15(27)5-3-14/h6-7,9-11,14-15,27H,2-5,24H2,1H3/t14-,15-
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n/an/a 10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439041
PNG
(US10604502, Ex # 29)
Show SMILES Cc1cc2n(cc(-c3c(F)ccc(N)c3F)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H21F2N3O/c1-12-8-20-16(9-13(12)10-25)17(21-18(23)6-7-19(26)22(21)24)11-27(20)14-2-4-15(28)5-3-14/h6-9,11,14-15,28H,2-5,26H2,1H3/t14-,15+
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n/an/a 12n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439093
PNG
(US10604502, Ex # 81)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc2cncn2c1
Show InChI InChI=1S/C22H15ClN6/c1-13-4-21-17(5-14(13)6-24)19(18-8-26-9-20(25)22(18)23)11-29(21)16-3-2-15-7-27-12-28(15)10-16/h2-5,7-12H,25H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439033
PNG
(US10604502, Ex # 21)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C22H16ClN5O/c1-12-6-20-16(7-14(12)8-24)18(17-9-27-10-19(25)21(17)23)11-28(20)15-4-2-13(3-5-15)22(26)29/h2-7,9-11H,25H2,1H3,(H2,26,29)
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n/an/a 12n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439077
PNG
(US10604502, Ex # 65)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@H](C1)NS(C)(=O)=O
Show InChI InChI=1S/C21H22ClN5O2S/c1-12-5-20-16(6-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-27(20)15-4-3-14(7-15)26-30(2,28)29/h5-6,9-11,14-15,26H,3-4,7,24H2,1-2H3/t14-,15+/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439038
PNG
(US10604502, Ex # 26)
Show SMILES Cc1cc2n(cc(-c3c(C)c(N)ccc3F)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C23H24FN3O/c1-13-9-22-18(10-15(13)11-25)19(23-14(2)21(26)8-7-20(23)24)12-27(22)16-3-5-17(28)6-4-16/h7-10,12,16-17,28H,3-6,26H2,1-2H3/t16-,17-
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n/an/a 14n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439062
PNG
(US10604502, Ex # 50)
Show SMILES COC(=O)N1CCC(CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C22H22ClN5O2/c1-13-7-20-16(8-14(13)9-24)18(17-10-26-11-19(25)21(17)23)12-28(20)15-3-5-27(6-4-15)22(29)30-2/h7-8,10-12,15H,3-6,25H2,1-2H3
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n/an/a 14n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439094
PNG
(US10604502, Ex # 82)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccn2cnnc2c1
Show InChI InChI=1S/C21H14ClN7/c1-12-4-19-15(5-13(12)7-23)17(16-8-25-9-18(24)21(16)22)10-29(19)14-2-3-28-11-26-27-20(28)6-14/h2-6,8-11H,24H2,1H3
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n/an/a 15n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439044
PNG
(US10604502, Ex # 32)
Show SMILES Cc1cc2n(cc(-c3cc(N)cc(c3)C#N)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C23H22N4O/c1-14-6-23-21(10-17(14)12-25)22(16-7-15(11-24)8-18(26)9-16)13-27(23)19-2-4-20(28)5-3-19/h6-10,13,19-20,28H,2-5,26H2,1H3/t19-,20-
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n/an/a 16n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439080
PNG
(3(3-(5-amino-4-chloropyridin-3-yl)-5-cyano-6-methy...)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CCC(C1)C(N)=O
Show InChI InChI=1S/C21H20ClN5O/c1-11-4-19-15(6-13(11)7-23)17(16-8-26-9-18(24)20(16)22)10-27(19)14-3-2-12(5-14)21(25)28/h4,6,8-10,12,14H,2-3,5,24H2,1H3,(H2,25,28)
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n/an/a 16n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439074
PNG
(US10604502, Ex # 62)
Show SMILES CC(=O)N[C@@H]1CC[C@H](C1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C22H22ClN5O/c1-12-5-21-17(6-14(12)8-24)19(18-9-26-10-20(25)22(18)23)11-28(21)16-4-3-15(7-16)27-13(2)29/h5-6,9-11,15-16H,3-4,7,25H2,1-2H3,(H,27,29)/t15-,16-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439022
PNG
(US10604502, Ex # 10)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CCC[C@H](O)C1
Show InChI InChI=1S/C21H21ClN4O/c1-12-5-20-16(6-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-3-2-4-15(27)7-14/h5-6,9-11,14-15,27H,2-4,7,24H2,1H3/t14-,15+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439064
PNG
(US10604502, Ex # 52)
Show SMILES CC(=O)N[C@H]1CC[C@H](CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C23H24ClN5O/c1-13-7-22-18(8-15(13)9-25)20(19-10-27-11-21(26)23(19)24)12-29(22)17-5-3-16(4-6-17)28-14(2)30/h7-8,10-12,16-17H,3-6,26H2,1-2H3,(H,28,30)/t16-,17+
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n/an/a 18n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439069
PNG
(US10604502, Ex # 57)
Show SMILES CC(=O)N1CCCC(C1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C22H22ClN5O/c1-13-6-21-17(7-15(13)8-24)19(18-9-26-10-20(25)22(18)23)12-28(21)16-4-3-5-27(11-16)14(2)29/h6-7,9-10,12,16H,3-5,11,25H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439086
PNG
(US10604502, Ex # 74)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1C[C@H](C1)S(C)(=O)=O
Show InChI InChI=1S/C20H19ClN4O2S/c1-11-3-19-15(4-12(11)7-22)17(16-8-24-9-18(23)20(16)21)10-25(19)13-5-14(6-13)28(2,26)27/h3-4,8-10,13-14H,5-6,23H2,1-2H3/t13-,14+
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n/an/a 20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439066
PNG
(US10604502, Ex # 54)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CCC(N)CC1
Show InChI InChI=1S/C21H22ClN5/c1-12-6-20-16(7-13(12)8-23)18(17-9-26-10-19(25)21(17)22)11-27(20)15-4-2-14(24)3-5-15/h6-7,9-11,14-15H,2-5,24-25H2,1H3
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n/an/a 23n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439075
PNG
(US10604502, Ex # 63)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@H](C1)NS(C)(=O)=O
Show InChI InChI=1S/C21H22ClN5O2S/c1-12-5-20-16(6-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-27(20)15-4-3-14(7-15)26-30(2,28)29/h5-6,9-11,14-15,26H,3-4,7,24H2,1-2H3/t14-,15-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439026
PNG
(US10604502, Ex # 14)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1C[C@H](O)C1
Show InChI InChI=1S/C19H17ClN4O/c1-10-2-18-14(3-11(10)6-21)16(9-24(18)12-4-13(25)5-12)15-7-23-8-17(22)19(15)20/h2-3,7-9,12-13,25H,4-5,22H2,1H3/t12-,13+
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n/an/a 24n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439047
PNG
(US10604502, Ex # 35)
Show SMILES Cc1cc2n(CC(O)CO)cc(-c3cccc4NC(C)(C)CCc34)c2cc1C#N
Show InChI InChI=1S/C24H27N3O2/c1-15-9-23-20(10-16(15)11-25)21(13-27(23)12-17(29)14-28)18-5-4-6-22-19(18)7-8-24(2,3)26-22/h4-6,9-10,13,17,26,28-29H,7-8,12,14H2,1-3H3
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n/an/a 25n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439110
PNG
(US10604502, Ex # 98)
Show SMILES Cc1cc2n(cc(-c3cccc4NCCCc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H27N3O/c1-16-12-25-22(13-17(16)14-26)23(15-28(25)18-7-9-19(29)10-8-18)20-4-2-6-24-21(20)5-3-11-27-24/h2,4,6,12-13,15,18-19,27,29H,3,5,7-11H2,1H3/t18-,19-
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n/an/a 25n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439057
PNG
((1R,4R)-4-(3-(5-amino-4-chloropyridin-3-yl)-5-cyan...)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@@H](CC1)C(N)=O
Show InChI InChI=1S/C22H22ClN5O/c1-12-6-20-16(7-14(12)8-24)18(17-9-27-10-19(25)21(17)23)11-28(20)15-4-2-13(3-5-15)22(26)29/h6-7,9-11,13,15H,2-5,25H2,1H3,(H2,26,29)/t13-,15-
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n/an/a 26n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439016
PNG
(US10604502, Ex # 15 | US10604502, Ex # 4)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3C(F)F)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H22F2N4O/c1-12-6-20-16(7-13(12)8-25)18(11-28(20)14-2-4-15(29)5-3-14)17-9-27-10-19(26)21(17)22(23)24/h6-7,9-11,14-15,22,29H,2-5,26H2,1H3/t14-,15+
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n/an/a 26n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439016
PNG
(US10604502, Ex # 15 | US10604502, Ex # 4)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3C(F)F)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H22F2N4O/c1-12-6-20-16(7-13(12)8-25)18(11-28(20)14-2-4-15(29)5-3-14)17-9-27-10-19(26)21(17)22(23)24/h6-7,9-11,14-15,22,29H,2-5,26H2,1H3/t14-,15+
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n/an/a 27n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439023
PNG
(US10604502, Ex # 11)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@@H](O)C1
Show InChI InChI=1S/C20H19ClN4O/c1-11-4-19-15(5-12(11)7-22)17(16-8-24-9-18(23)20(16)21)10-25(19)13-2-3-14(26)6-13/h4-5,8-10,13-14,26H,2-3,6,23H2,1H3/t13-,14-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439019
PNG
(US10604502, Ex # 7)
Show SMILES Nc1cncc(-c2cn([C@H]3CC[C@H](O)CC3)c3cc(Cl)c(cc23)C#N)c1Cl
Show InChI InChI=1S/C20H18Cl2N4O/c21-17-6-19-14(5-11(17)7-23)16(15-8-25-9-18(24)20(15)22)10-26(19)12-1-3-13(27)4-2-12/h5-6,8-10,12-13,27H,1-4,24H2/t12-,13-
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n/an/a 28n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439095
PNG
(US10604502, Ex # 83)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccn2cncc2c1
Show InChI InChI=1S/C22H15ClN6/c1-13-4-21-17(5-14(13)7-24)19(18-9-26-10-20(25)22(18)23)11-29(21)15-2-3-28-12-27-8-16(28)6-15/h2-6,8-12H,25H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439040
PNG
(US10604502, Ex # 28)
Show SMILES Cc1cc2n(cc(-c3c(F)ccc(N)c3F)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H21F2N3O/c1-12-8-20-16(9-13(12)10-25)17(21-18(23)6-7-19(26)22(21)24)11-27(20)14-2-4-15(28)5-3-14/h6-9,11,14-15,28H,2-5,26H2,1H3/t14-,15-
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n/an/a 29n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439025
PNG
(US10604502, Ex # 13)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1C[C@H](O)C1
Show InChI InChI=1S/C19H17ClN4O/c1-10-2-18-14(3-11(10)6-21)16(9-24(18)12-4-13(25)5-12)15-7-23-8-17(22)19(15)20/h2-3,7-9,12-13,25H,4-5,22H2,1H3/t12-,13-
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n/an/a 30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439037
PNG
(3-(5-amino-4-chloropyridin-3-yl)-1-(3-hydroxypropy...)
Show SMILES Cc1c(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc2n1CCCO
Show InChI InChI=1S/C19H19ClN4O/c1-11-6-17-14(7-13(11)8-21)18(12(2)24(17)4-3-5-25)15-9-23-10-16(22)19(15)20/h6-7,9-10,25H,3-5,22H2,1-2H3
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n/an/a 31n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439078
PNG
(US10604502, Ex # 66)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@@H](C1)NS(C)(=O)=O
Show InChI InChI=1S/C21H22ClN5O2S/c1-12-5-20-16(6-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-27(20)15-4-3-14(7-15)26-30(2,28)29/h5-6,9-11,14-15,26H,3-4,7,24H2,1-2H3/t14-,15-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439067
PNG
(US10604502, Ex # 55)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H22ClN5O2S/c1-13-7-20-16(8-14(13)9-23)18(17-10-25-11-19(24)21(17)22)12-27(20)15-3-5-26(6-4-15)30(2,28)29/h7-8,10-12,15H,3-6,24H2,1-2H3
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n/an/a 33n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439030
PNG
(3-(3-amino-2-chlorophenyl)-1-(3-hydroxypropyl)-6-m...)
Show SMILES Cc1cc2n(CCCO)cc(-c3cccc(N)c3Cl)c2cc1C#N
Show InChI InChI=1S/C19H18ClN3O/c1-12-8-18-15(9-13(12)10-21)16(11-23(18)6-3-7-24)14-4-2-5-17(22)19(14)20/h2,4-5,8-9,11,24H,3,6-7,22H2,1H3
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n/an/a 34n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439071
PNG
(3-(3-(5-amino-4-chloropyridin-3-yl)-5-cyano-6-meth...)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CCCC(C1)C(N)=O
Show InChI InChI=1S/C22H22ClN5O/c1-12-5-20-16(7-14(12)8-24)18(17-9-27-10-19(25)21(17)23)11-28(20)15-4-2-3-13(6-15)22(26)29/h5,7,9-11,13,15H,2-4,6,25H2,1H3,(H2,26,29)
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n/an/a 34n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439063
PNG
(US10604502, Ex # 51)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CCC(C)(O)CC1
Show InChI InChI=1S/C22H23ClN4O/c1-13-7-20-16(8-14(13)9-24)18(17-10-26-11-19(25)21(17)23)12-27(20)15-3-5-22(2,28)6-4-15/h7-8,10-12,15,28H,3-6,25H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439068
PNG
(3-(5-amino-4-chloropyridin-3-yl)-6-methyl-1-(1-met...)
Show SMILES CN1CC(CCC1=O)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C21H20ClN5O/c1-12-5-19-15(6-13(12)7-23)17(16-8-25-9-18(24)21(16)22)11-27(19)14-3-4-20(28)26(2)10-14/h5-6,8-9,11,14H,3-4,10,24H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439072
PNG
(US10604502, Ex # 60)
Show SMILES COC(=O)N1CCC(C1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C21H20ClN5O2/c1-12-5-19-15(6-13(12)7-23)17(16-8-25-9-18(24)20(16)22)11-27(19)14-3-4-26(10-14)21(28)29-2/h5-6,8-9,11,14H,3-4,10,24H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439065
PNG
(US10604502, Ex # 53)
Show SMILES CC(=O)N[C@H]1CC[C@@H](CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C23H24ClN5O/c1-13-7-22-18(8-15(13)9-25)20(19-10-27-11-21(26)23(19)24)12-29(22)17-5-3-16(4-6-17)28-14(2)30/h7-8,10-12,16-17H,3-6,26H2,1-2H3,(H,28,30)/t16-,17-
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n/an/a 40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439111
PNG
(US10604502, Ex # 99)
Show SMILES Cc1cc2n(cc(-c3cccc4NCCCc34)c2cc1C#N)[C@@H]1CC[C@@H](O)C1
Show InChI InChI=1S/C24H25N3O/c1-15-10-24-21(11-16(15)13-25)22(14-27(24)17-7-8-18(28)12-17)19-4-2-6-23-20(19)5-3-9-26-23/h2,4,6,10-11,14,17-18,26,28H,3,5,7-9,12H2,1H3/t17-,18-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439096
PNG
(US10604502, Ex # 84)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C21H16ClN5O/c1-12-5-19-15(6-13(12)7-23)17(16-8-25-9-18(24)21(16)22)11-27(19)14-3-4-20(28)26(2)10-14/h3-6,8-11H,24H2,1-2H3
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n/an/a 49n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439049
PNG
(US10604502, Ex # 37)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@H](C1)S(C)(=O)=O
Show InChI InChI=1S/C21H21ClN4O2S/c1-12-5-20-16(6-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-3-4-15(7-14)29(2,27)28/h5-6,9-11,14-15H,3-4,7,24H2,1-2H3/t14-,15-/m1/s1
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n/an/a 52n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439020
PNG
(US10604502, Ex # 8)
Show SMILES Nc1cncc(-c2cn([C@@H]3CC[C@H](O)CC3)c3cc(Cl)c(cc23)C#N)c1Cl
Show InChI InChI=1S/C20H18Cl2N4O/c21-17-6-19-14(5-11(17)7-23)16(15-8-25-9-18(24)20(15)22)10-26(19)12-1-3-13(27)4-2-12/h5-6,8-10,12-13,27H,1-4,24H2/t12-,13+
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n/an/a 63n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439087
PNG
(US10604502, Ex # 75)
Show SMILES CC(=O)N1CCC(CC1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C22H22ClN5O/c1-13-7-21-17(8-15(13)9-24)19(18-10-26-11-20(25)22(18)23)12-28(21)16-3-5-27(6-4-16)14(2)29/h7-8,10-12,16H,3-6,25H2,1-2H3
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n/an/a 67n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439099
PNG
(US10604502, Ex # 87)
Show SMILES Cc1cc2n(cc(-c3ccc(Br)c(N)c3C)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C23H24BrN3O/c1-13-9-22-19(10-15(13)11-25)20(18-7-8-21(24)23(26)14(18)2)12-27(22)16-3-5-17(28)6-4-16/h7-10,12,16-17,28H,3-6,26H2,1-2H3/t16-,17-
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n/an/a 67n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439097
PNG
(US10604502, Ex # 85)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccn(C)c(=O)c1
Show InChI InChI=1S/C21H16ClN5O/c1-12-5-19-15(6-13(12)8-23)17(16-9-25-10-18(24)21(16)22)11-27(19)14-3-4-26(2)20(28)7-14/h3-7,9-11H,24H2,1-2H3
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n/an/a 69n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439088
PNG
(US10604502, Ex # 76)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CC2(COC2)C1
Show InChI InChI=1S/C21H19ClN4O/c1-12-2-19-15(3-13(12)6-23)17(16-7-25-8-18(24)20(16)22)9-26(19)14-4-21(5-14)10-27-11-21/h2-3,7-9,14H,4-5,10-11,24H2,1H3
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n/an/a 70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439031
PNG
(3-(5-amino-4-methylpyridin-3-yl)-1-(3-hydroxypropy...)
Show SMILES Cc1cc2n(CCCO)cc(-c3cncc(N)c3C)c2cc1C#N
Show InChI InChI=1S/C19H20N4O/c1-12-6-19-15(7-14(12)8-20)17(11-23(19)4-3-5-24)16-9-22-10-18(21)13(16)2/h6-7,9-11,24H,3-5,21H2,1-2H3
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n/an/a 71n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439029
PNG
(3-(3-amino-2-fluorophenyl)-1-(3-hydroxypropyl)-6-m...)
Show SMILES Cc1cc2n(CCCO)cc(-c3cccc(N)c3F)c2cc1C#N
Show InChI InChI=1S/C19H18FN3O/c1-12-8-18-15(9-13(12)10-21)16(11-23(18)6-3-7-24)14-4-2-5-17(22)19(14)20/h2,4-5,8-9,11,24H,3,6-7,22H2,1H3
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n/an/a 73n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439076
PNG
(US10604502, Ex # 64)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@@H](C1)NS(C)(=O)=O
Show InChI InChI=1S/C21H22ClN5O2S/c1-12-5-20-16(6-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-27(20)15-4-3-14(7-15)26-30(2,28)29/h5-6,9-11,14-15,26H,3-4,7,24H2,1-2H3/t14-,15+/m0/s1
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n/an/a 77n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439083
PNG
(US10604502, Ex # 71)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CC(C1)C(N)=O
Show InChI InChI=1S/C20H18ClN5O/c1-10-2-18-14(5-12(10)6-22)16(15-7-25-8-17(23)19(15)21)9-26(18)13-3-11(4-13)20(24)27/h2,5,7-9,11,13H,3-4,23H2,1H3,(H2,24,27)
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n/an/a 77n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439084
PNG
(US10604502, Ex # 72)
Show SMILES CN(C1CC(C1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12)C(C)=O
Show InChI InChI=1S/C22H22ClN5O/c1-12-4-21-17(5-14(12)8-24)19(18-9-26-10-20(25)22(18)23)11-28(21)16-6-15(7-16)27(3)13(2)29/h4-5,9-11,15-16H,6-7,25H2,1-3H3
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n/an/a 89n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439028
PNG
(US10604502, Ex # 16)
Show SMILES Cc1cc2n(CCCO)cc(-c3cncc(N)c3C(F)F)c2cc1C#N
Show InChI InChI=1S/C19H18F2N4O/c1-11-5-17-13(6-12(11)7-22)15(10-25(17)3-2-4-26)14-8-24-9-16(23)18(14)19(20)21/h5-6,8-10,19,26H,2-4,23H2,1H3
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n/an/a 94n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439070
PNG
(US10604502, Ex # 58)
Show SMILES COC(=O)C1CCCC(C1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C23H23ClN4O2/c1-13-6-21-17(8-15(13)9-25)19(18-10-27-11-20(26)22(18)24)12-28(21)16-5-3-4-14(7-16)23(29)30-2/h6,8,10-12,14,16H,3-5,7,26H2,1-2H3
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n/an/a 105n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439073
PNG
(US10604502, Ex # 61)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CCN(C1)S(C)(=O)=O
Show InChI InChI=1S/C20H20ClN5O2S/c1-12-5-19-15(6-13(12)7-22)17(16-8-24-9-18(23)20(16)21)11-26(19)14-3-4-25(10-14)29(2,27)28/h5-6,8-9,11,14H,3-4,10,23H2,1-2H3
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n/an/a 127n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439017
PNG
(US10604502, Ex # 5)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3F)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C21H21FN4O/c1-12-6-20-16(7-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-2-4-15(27)5-3-14/h6-7,9-11,14-15,27H,2-5,24H2,1H3/t14-,15-
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n/an/a 135n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439032
PNG
(US10604502, Ex # 20)
Show SMILES CC(C)Nc1cccc(-c2cn([C@H]3CC[C@H](O)CC3)c3cc(C)c(cc23)C#N)c1C
Show InChI InChI=1S/C26H31N3O/c1-16(2)28-25-7-5-6-22(18(25)4)24-15-29(20-8-10-21(30)11-9-20)26-12-17(3)19(14-27)13-23(24)26/h5-7,12-13,15-16,20-21,28,30H,8-11H2,1-4H3/t20-,21-
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n/an/a 153n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439112
PNG
(US10604502, Ex # 100)
Show SMILES Cc1cc2n(cc(-c3cccc4NCCc34)c2cc1C#N)[C@@H]1CC[C@@H](O)C1
Show InChI InChI=1S/C23H23N3O/c1-14-9-23-20(10-15(14)12-24)21(13-26(23)16-5-6-17(27)11-16)18-3-2-4-22-19(18)7-8-25-22/h2-4,9-10,13,16-17,25,27H,5-8,11H2,1H3/t16-,17-/m1/s1
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n/an/a 154n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439114
PNG
(US10604502, Ex # 102)
Show SMILES Cc1cc2n(cc(-c3cccc4NCC(C)(C)Cc34)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H31N3O/c1-17-11-26-22(12-18(17)14-28)24(15-30(26)19-7-9-20(31)10-8-19)21-5-4-6-25-23(21)13-27(2,3)16-29-25/h4-6,11-12,15,19-20,29,31H,7-10,13,16H2,1-3H3/t19-,20+
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n/an/a 154n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439048
PNG
(US10604502, Ex # 36)
Show SMILES Cc1cc2n(CCC(O)CO)cc(-c3cccc4NC(C)(C)CCc34)c2cc1C#N
Show InChI InChI=1S/C25H29N3O2/c1-16-11-24-21(12-17(16)13-26)22(14-28(24)10-8-18(30)15-29)19-5-4-6-23-20(19)7-9-25(2,3)27-23/h4-6,11-12,14,18,27,29-30H,7-10,15H2,1-3H3
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n/an/a 157n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439061
PNG
(US10604502, Ex # 49)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C20H19ClN4O2S/c1-12-6-19-15(7-13(12)8-22)17(16-9-24-10-18(23)20(16)21)11-25(19)14-2-4-28(26,27)5-3-14/h6-7,9-11,14H,2-5,23H2,1H3
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n/an/a 158n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439045
PNG
(3-(3-amino-2,6-difluorophenyl)-1-(3-hydroxypropyl)...)
Show SMILES Cc1cc2n(CCCO)cc(-c3c(F)ccc(N)c3F)c2cc1C#N
Show InChI InChI=1S/C19H17F2N3O/c1-11-7-17-13(8-12(11)9-22)14(10-24(17)5-2-6-25)18-15(20)3-4-16(23)19(18)21/h3-4,7-8,10,25H,2,5-6,23H2,1H3
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n/an/a 162n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439034
PNG
(US10604502, Ex # 22)
Show SMILES Cc1c(N)cccc1-c1cn([C@H]2CC[C@H](O)CC2)c2cc(F)c(cc12)C#N
Show InChI InChI=1S/C22H22FN3O/c1-13-17(3-2-4-21(13)25)19-12-26(15-5-7-16(27)8-6-15)22-10-20(23)14(11-24)9-18(19)22/h2-4,9-10,12,15-16,27H,5-8,25H2,1H3/t15-,16-
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n/an/a 181n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439113
PNG
(US10604502, Ex # 101)
Show SMILES Cc1cc2n(cc(-c3cccc4NCC(C)(C)Cc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H31N3O/c1-17-11-26-22(12-18(17)14-28)24(15-30(26)19-7-9-20(31)10-8-19)21-5-4-6-25-23(21)13-27(2,3)16-29-25/h4-6,11-12,15,19-20,29,31H,7-10,13,16H2,1-3H3/t19-,20-
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n/an/a 185n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439098
PNG
(US10604502, Ex # 86)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)-c1ccc2nncn2c1
Show InChI InChI=1S/C21H14ClN7/c1-12-4-19-15(5-13(12)6-23)17(16-7-25-8-18(24)21(16)22)10-29(19)14-2-3-20-27-26-11-28(20)9-14/h2-5,7-11H,24H2,1H3
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n/an/a 188n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439082
PNG
(US10604502, Ex # 70)
Show SMILES CNC(=O)N1CCC(C1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C21H21ClN6O/c1-12-5-19-15(6-13(12)7-23)17(16-8-26-9-18(24)20(16)22)11-28(19)14-3-4-27(10-14)21(29)25-2/h5-6,8-9,11,14H,3-4,10,24H2,1-2H3,(H,25,29)
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n/an/a 191n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439043
PNG
(US10604502, Ex # 31)
Show SMILES Cc1cc2n(cc(-c3ccc(F)c(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H21ClFN3O/c1-12-8-20-17(9-13(12)10-25)18(16-6-7-19(24)22(26)21(16)23)11-27(20)14-2-4-15(28)5-3-14/h6-9,11,14-15,28H,2-5,26H2,1H3/t14-,15+
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n/an/a 204n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439050
PNG
(US10604502, Ex # 38)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@@H]1CC[C@@H](C1)S(C)(=O)=O
Show InChI InChI=1S/C21H21ClN4O2S/c1-12-5-20-16(6-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-3-4-15(7-14)29(2,27)28/h5-6,9-11,14-15H,3-4,7,24H2,1-2H3/t14-,15+/m1/s1
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n/an/a 206n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439018
PNG
(US10604502, Ex # 6)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3F)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C21H21FN4O/c1-12-6-20-16(7-13(12)8-23)18(17-9-25-10-19(24)21(17)22)11-26(20)14-2-4-15(27)5-3-14/h6-7,9-11,14-15,27H,2-5,24H2,1H3/t14-,15+
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n/an/a 206n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439053
PNG
(US10604502, Ex # 41)
Show SMILES Cc1cc2n(CCCOCCCO)cc(-c3cccc(N)c3F)c2cc1C#N
Show InChI InChI=1S/C22H24FN3O2/c1-15-11-21-18(12-16(15)13-24)19(17-5-2-6-20(25)22(17)23)14-26(21)7-3-9-28-10-4-8-27/h2,5-6,11-12,14,27H,3-4,7-10,25H2,1H3
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n/an/a 215n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439042
PNG
(US10604502, Ex # 30)
Show SMILES Cc1cc2n(cc(-c3ccc(F)c(N)c3Cl)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H21ClFN3O/c1-12-8-20-17(9-13(12)10-25)18(16-6-7-19(24)22(26)21(16)23)11-27(20)14-2-4-15(28)5-3-14/h6-9,11,14-15,28H,2-5,26H2,1H3/t14-,15-
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n/an/a 243n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439052
PNG
(US10604502, Ex # 40)
Show SMILES Cc1cc2n(cc(-c3cccc4NC(C)(C)CCc34)c2cc1C#N)C1CNC1
Show InChI InChI=1S/C24H26N4/c1-15-9-23-20(10-16(15)11-25)21(14-28(23)17-12-26-13-17)18-5-4-6-22-19(18)7-8-24(2,3)27-22/h4-6,9-10,14,17,26-27H,7-8,12-13H2,1-3H3
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n/an/a 259n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439051
PNG
(US10604502, Ex # 39)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1C[C@@H](C1)C#N
Show InChI InChI=1S/C20H16ClN5/c1-11-2-19-15(5-13(11)7-23)17(16-8-25-9-18(24)20(16)21)10-26(19)14-3-12(4-14)6-22/h2,5,8-10,12,14H,3-4,24H2,1H3/t12-,14-
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n/an/a 266n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439118
PNG
(3-(5-amino-4-chloropyridin-3-yl)-2,6-dimethyl-1-(3...)
Show SMILES Cc1c(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc2n1CCCS(C)(=O)=O
Show InChI InChI=1S/C20H21ClN4O2S/c1-12-7-18-15(8-14(12)9-22)19(16-10-24-11-17(23)20(16)21)13(2)25(18)5-4-6-28(3,26)27/h7-8,10-11H,4-6,23H2,1-3H3
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n/an/a 359n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439054
PNG
(3-(3-amino-2-cyanophenyl)-1-(3-hydroxypropyl)-6-me...)
Show SMILES Cc1cc2n(CCCO)cc(-c3cccc(N)c3C#N)c2cc1C#N
Show InChI InChI=1S/C20H18N4O/c1-13-8-20-16(9-14(13)10-21)18(12-24(20)6-3-7-25)15-4-2-5-19(23)17(15)11-22/h2,4-5,8-9,12,25H,3,6-7,23H2,1H3
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n/an/a 365n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439085
PNG
(US10604502, Ex # 73)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1C[C@@H](C1)S(C)(=O)=O
Show InChI InChI=1S/C20H19ClN4O2S/c1-11-3-19-15(4-12(11)7-22)17(16-8-24-9-18(23)20(16)21)10-25(19)13-5-14(6-13)28(2,26)27/h3-4,8-10,13-14H,5-6,23H2,1-2H3/t13-,14-
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n/an/a 379n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439081
PNG
(US10604502, Ex # 69)
Show SMILES CC(=O)N1CCC(C1)n1cc(-c2cncc(N)c2Cl)c2cc(C#N)c(C)cc12
Show InChI InChI=1S/C21H20ClN5O/c1-12-5-20-16(6-14(12)7-23)18(17-8-25-9-19(24)21(17)22)11-27(20)15-3-4-26(10-15)13(2)28/h5-6,8-9,11,15H,3-4,10,24H2,1-2H3
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n/an/a 414n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439058
PNG
((1R,4R)-4-(3-(5-amino-4-chloropyridin-3-yl)-5-cyan...)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C22H21ClN4O2/c1-12-6-20-16(7-14(12)8-24)18(17-9-26-10-19(25)21(17)23)11-27(20)15-4-2-13(3-5-15)22(28)29/h6-7,9-11,13,15H,2-5,25H2,1H3,(H,28,29)/t13-,15-
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n/an/a 476n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439115
PNG
(1-((1R,4R)-4-hydroxycyclohexyl)-6-methyl-3-(2-oxo-...)
Show SMILES Cc1cc2n(cc(-c3cccc4NC(=O)CCc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H25N3O2/c1-15-11-24-21(12-16(15)13-26)22(14-28(24)17-5-7-18(29)8-6-17)19-3-2-4-23-20(19)9-10-25(30)27-23/h2-4,11-12,14,17-18,29H,5-10H2,1H3,(H,27,30)/t17-,18-
PDB
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n/an/a 512n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439055
PNG
(3-(5-amino-4-chloropyridin-3-yl)-1-(1,1-dioxidothi...)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)C1CS(=O)(=O)C1
Show InChI InChI=1S/C18H15ClN4O2S/c1-10-2-17-13(3-11(10)4-20)15(14-5-22-6-16(21)18(14)19)7-23(17)12-8-26(24,25)9-12/h2-3,5-7,12H,8-9,21H2,1H3
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n/an/a 588n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439116
PNG
(US10604502, Ex # 104)
Show SMILES Cc1cc2n(cc(-c3cccc4NCCc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C24H25N3O/c1-15-11-24-21(12-16(15)13-25)22(14-27(24)17-5-7-18(28)8-6-17)19-3-2-4-23-20(19)9-10-26-23/h2-4,11-12,14,17-18,26,28H,5-10H2,1H3/t17-,18-
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n/an/a 776n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439060
PNG
(US10604502, Ex # 48)
Show SMILES Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1CC[C@H](CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H23ClN4O2S/c1-13-7-21-17(8-14(13)9-24)19(18-10-26-11-20(25)22(18)23)12-27(21)15-3-5-16(6-4-15)30(2,28)29/h7-8,10-12,15-16H,3-6,25H2,1-2H3/t15-,16+
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n/an/a 930n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439102
PNG
(US10604502, Ex # 90)
Show SMILES Cc1cc2n(cc(-c3cncc4NCCOc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C23H24N4O2/c1-14-8-22-18(9-15(14)10-24)20(13-27(22)16-2-4-17(28)5-3-16)19-11-25-12-21-23(19)29-7-6-26-21/h8-9,11-13,16-17,26,28H,2-7H2,1H3/t16-,17-
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n/an/a 955n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439035
PNG
(US10604502, Ex # 23)
Show SMILES Cc1c(-c2cncc(N)c2)c2cc(C#N)c(C)cc2n1CCCO
Show InChI InChI=1S/C19H20N4O/c1-12-6-18-17(8-14(12)9-20)19(13(2)23(18)4-3-5-24)15-7-16(21)11-22-10-15/h6-8,10-11,24H,3-5,21H2,1-2H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439117
PNG
(US10604502, Ex # 105)
Show SMILES Cc1cc2n(cc(-c3ccc4CCNc4c3C)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H27N3O/c1-15-11-24-22(12-18(15)13-26)23(14-28(24)19-4-6-20(29)7-5-19)21-8-3-17-9-10-27-25(17)16(21)2/h3,8,11-12,14,19-20,27,29H,4-7,9-10H2,1-2H3/t19-,20-
PDB
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n/an/a 1.94E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439103
PNG
(US10604502, Ex # 91)
Show SMILES Cc1cc2n(cc(-c3cnc4CCC(C)(C)Nc4c3)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H30N4O/c1-16-10-25-21(11-17(16)13-27)22(15-30(25)19-4-6-20(31)7-5-19)18-12-24-23(28-14-18)8-9-26(2,3)29-24/h10-12,14-15,19-20,29,31H,4-9H2,1-3H3/t19-,20-
PDB
MMDB

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n/an/a 9.17E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439119
PNG
(US10604502, Ex # 107)
Show SMILES Cc1cc2n(cc(-c3cnc(Br)c(N)c3Cl)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C21H20BrClN4O/c1-11-6-18-15(7-12(11)8-24)17(16-9-26-21(22)20(25)19(16)23)10-27(18)13-2-4-14(28)5-3-13/h6-7,9-10,13-14,28H,2-5,25H2,1H3/t13-,14-
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n/an/a 9.62E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439104
PNG
(US10604502, Ex # 92)
Show SMILES Cc1cc2n(cc(-c3cnc4C=CC(C)(C)Nc4c3)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H28N4O/c1-16-10-25-21(11-17(16)13-27)22(15-30(25)19-4-6-20(31)7-5-19)18-12-24-23(28-14-18)8-9-26(2,3)29-24/h8-12,14-15,19-20,29,31H,4-7H2,1-3H3/t19-,20+
PDB
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n/an/a 2.21E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439105
PNG
(US10604502, Ex # 93)
Show SMILES Cc1cc2n(cc(-c3cnc4CCC(C)(C)Nc4c3)c2cc1C#N)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H30N4O/c1-16-10-25-21(11-17(16)13-27)22(15-30(25)19-4-6-20(31)7-5-19)18-12-24-23(28-14-18)8-9-26(2,3)29-24/h10-12,14-15,19-20,29,31H,4-9H2,1-3H3/t19-,20+
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n/an/a 2.83E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM439106
PNG
(US10604502, Ex # 94)
Show SMILES Cc1cc2n(cc(-c3cnc4C=CC(C)(C)Nc4c3)c2cc1C#N)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H28N4O/c1-16-10-25-21(11-17(16)13-27)22(15-30(25)19-4-6-20(31)7-5-19)18-12-24-23(28-14-18)8-9-26(2,3)29-24/h8-12,14-15,19-20,29,31H,4-7H2,1-3H3/t19-,20-
PDB
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n/an/a 6.37E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...


US Patent US10604502 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%