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Patent code US10604531

Compile Data Set for Download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439132
PNG
((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES CC(C)CN1CCC(CC1)[C@@H](C)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439169
PNG
((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES C[C@H](C1CCN(CC2(C)CCCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439163
PNG
((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES CCC(C)(C)CN1CCC(CC1)[C@@H](C)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439192
PNG
((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES C[C@H](C1CCN(CC2(C)CCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439130
PNG
((R)-2-(1-(1-(Cyclobutylmethyl)piperidin-4-yl)ethyl...)
Show SMILES C[C@H](C1CCN(CC2CCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439133
PNG
((R)-2-(1-(1-(Cyclopentylmethyl)piperidin-4-yl)ethy...)
Show SMILES C[C@H](C1CCN(CC2CCCC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439165
PNG
((R)-2-(1-(1-(Cyclopropylmethyl)piperidin-4-yl)ethy...)
Show SMILES C[C@H](C1CCN(CC2CC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439197
PNG
((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES C[C@H](C1CCN(CC2(C)CC2)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439190
PNG
((R)-2-(1-(1-(Bicyclo[2.2.2]octan-1-ylmethyl)piperi...)
Show SMILES C[C@H](C1CCN(CC23CCC(CC2)CC3)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439129
PNG
((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES C[C@H](C1CCN(CC(C)(C)C)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM439164
PNG
((R)-5-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl...)
Show SMILES C[C@H](C1CCN(CC(C)(C)F)CC1)c1sc2CCCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1C
PDB

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GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

US Patent


Assay Description
1. Prepare 10 mM stock of compounds from solid in 100% DMSO.2. Set up an 11-point serial dilution (1:4 dilution, top concentration 10 mM) in 100% DMS...


US Patent US10604531 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%