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Patent code US10604535

Compile Data Set for Download or QSAR

Found 251 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356236
PNG
(US10604535, Example 6 | US9815850, Compound 6 | US...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)c(C)c2F)C1=O
Show InChI InChI=1S/C22H21FN4O3/c1-14-19(23)20(25-27(14)12-15-8-4-3-5-9-15)21(28)24-16-13-30-18-11-7-6-10-17(18)26(2)22(16)29/h3-11,16H,12-13H2,1-2H3,(H,24,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356237
PNG
(US10604535, Example 7 | US9815850, Compound 7 | US...)
Show SMILES CN1c2ccccc2C2CC2[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C23H21N3O3/c1-26-20-10-6-5-9-16(20)17-13-18(17)21(23(26)28)24-22(27)19-12-15(29-25-19)11-14-7-3-2-4-8-14/h2-10,12,17-18,21H,11,13H2,1H3,(H,24,27)/t17?,18?,21-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356238
PNG
(US10604535, Example 7A | US9815850, Compound 7A | ...)
Show SMILES CN1c2ccccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C23H21N3O3/c1-26-20-10-6-5-9-16(20)17-13-18(17)21(23(26)28)24-22(27)19-12-15(29-25-19)11-14-7-3-2-4-8-14/h2-10,12,17-18,21H,11,13H2,1H3,(H,24,27)/t17-,18-,21-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356246
PNG
(US10604535, Example 12A | US9815850, Compound 12 |...)
Show SMILES CN1c2ccccc2[C@@H](F)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356275
PNG
(US10604535, Example 46A | US9815850, Compound 46A ...)
Show SMILES CN1c2ccccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356281
PNG
(US10604535, Example 52 | US9815850, Compound 52 | ...)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2ccnc12)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356282
PNG
(US10604535, Example 54B | US9815850, Compound 54A ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356285
PNG
(US10604535, Example 56 | US9815850, Compound 56 | ...)
Show SMILES CN1c2cccc(C#N)c2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356286
PNG
(US10604535, Example 57 | US9815850, Compound 57 | ...)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2NC1=O
Show InChI InChI=1S/C19H16FN5O3/c20-13-10-25(9-12-5-2-1-3-6-12)24-16(13)19(27)22-14-11-28-15-7-4-8-21-17(15)23-18(14)26/h1-8,10,14H,9,11H2,(H,22,27)(H,21,23,26)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356288
PNG
(US10604535, Example 59 | US9815850, Compound 59 | ...)
Show SMILES CN1c2ccccc2C2(CC2)C[C@H](NC(=O)c2cc(Cc3ccccc3)[nH]n2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356301
PNG
(US10604535, Example 69A | US9815850, Compound 69A ...)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2cnnc12)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM373573
PNG
(US10604535, Example 74 | US9896458, No. 74)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccn3)cc2F)C1=O
Show InChI InChI=1S/C19H17FN6O3/c1-25-17-15(6-4-8-22-17)29-11-14(19(25)28)23-18(27)16-13(20)10-26(24-16)9-12-5-2-3-7-21-12/h2-8,10,14H,9,11H2,1H3,(H,23,27)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356312
PNG
(US10604535, Example 175 | US9815850, Compound 175 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C20H18FN5O3/c1-25-18-16(8-5-9-22-18)29-12-15(20(25)28)23-19(27)17-14(21)11-26(24-17)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,23,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356340
PNG
(US10604535, Example 98B | US9815850, Compound 98B ...)
Show SMILES O=C(N[C@H]1CC2(CC2)c2cccnc2NC1=O)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356358
PNG
(US10604535, Example 109A | US9815850, Compound 109...)
Show SMILES CN1c2cn(C)nc2CC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C20H21FN6O2/c1-25-12-17-15(23-25)8-9-16(20(29)26(17)2)22-19(28)18-14(21)11-27(24-18)10-13-6-4-3-5-7-13/h3-7,11-12,16H,8-10H2,1-2H3,(H,22,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356361
PNG
(US10604535, Example 110B | US9815850, Compound 110...)
Show SMILES O=C(N[C@H]1[C@H]2C[C@H]2c2cccnc2NC1=O)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356368
PNG
(US10604535, Example 115 | US9815850, Compound 115 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccc(F)cc3)cc2F)C1=O
Show InChI InChI=1S/C20H17F2N5O3/c1-26-18-16(3-2-8-23-18)30-11-15(20(26)29)24-19(28)17-14(22)10-27(25-17)9-12-4-6-13(21)7-5-12/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356369
PNG
(US10604535, Example 116 | US9815850, Compound 116 ...)
Show SMILES Fc1ccccc1Oc1cnnc(c1)C(=O)N[C@H]1CCc2ccccc2-n2ccnc12
Show InChI InChI=1S/C23H18FN5O2/c24-17-6-2-4-8-21(17)31-16-13-19(28-26-14-16)23(30)27-18-10-9-15-5-1-3-7-20(15)29-12-11-25-22(18)29/h1-8,11-14,18H,9-10H2,(H,27,30)/t18-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356380
PNG
(US10604535, Example 123 | US9815850, Compound 123 ...)
Show SMILES O=C(N[C@H]1COc2cccnc2NC1=O)c1ncc(Cc2ccccc2)s1
Show InChI InChI=1S/C19H16N4O3S/c24-17-14(11-26-15-7-4-8-20-16(15)23-17)22-18(25)19-21-10-13(27-19)9-12-5-2-1-3-6-12/h1-8,10,14H,9,11H2,(H,22,25)(H,20,23,24)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356383
PNG
(US10604535, Example 125B | US9815850, Compound 125...)
Show SMILES CN1c2ncccc2C2(CC2)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM439446
PNG
(US10604535, Example 126)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nc(F)c(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356385
PNG
(US10604535, Example 127 | US9815850, Compound 127 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nn(Cc2ccc(cc2)C#N)cc1F
Show InChI InChI=1S/C22H19FN6O3/c1-13-18(22(31)28(2)20-17(32-13)4-3-9-25-20)26-21(30)19-16(23)12-29(27-19)11-15-7-5-14(10-24)6-8-15/h3-9,12-13,18H,11H2,1-2H3,(H,26,30)/t13-,18+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356394
PNG
(US10604535, Example 174 | US9815850, Compound 134 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C20H19N5O4/c1-12-16(20(27)25(2)17-14(28-12)9-6-10-21-17)22-18(26)19-24-23-15(29-19)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,22,26)/t12-,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356396
PNG
(US10604535, Example 136 | US9815850, Compound 136 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncn(Cc2ccccc2)n1
Show InChI InChI=1S/C20H20N6O3/c1-13-16(20(28)25(2)18-15(29-13)9-6-10-21-18)23-19(27)17-22-12-26(24-17)11-14-7-4-3-5-8-14/h3-10,12-13,16H,11H2,1-2H3,(H,23,27)/t13-,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356406
PNG
(US10604535, Example 145A | US9815850, Compound 145...)
Show SMILES CN1c2ncccc2CC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C22H21N5O3/c1-27-17-14(6-5-13-23-17)9-10-16(20(27)29)24-18(28)19-25-26-21(30-19)22(11-12-22)15-7-3-2-4-8-15/h2-8,13,16H,9-12H2,1H3,(H,24,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356419
PNG
(US10604535, Example 154B | US9815850, Compound 154...)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2-n2ccnc12
Show InChI InChI=1S/C21H17FN6O2/c22-15-12-27(11-14-5-2-1-3-6-14)26-18(15)21(29)25-16-13-30-17-7-4-8-23-20(17)28-10-9-24-19(16)28/h1-10,12,16H,11,13H2,(H,25,29)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356425
PNG
(US10604535, Example 158 | US9815850, Compound 158 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(C#N)n(Cc3ccccc3)n2)C1=O
Show InChI InChI=1S/C21H18N6O3/c1-26-19-18(8-5-9-23-19)30-13-17(21(26)29)24-20(28)16-10-15(11-22)27(25-16)12-14-6-3-2-4-7-14/h2-10,17H,12-13H2,1H3,(H,24,28)/t17-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356440
PNG
(US10604535, Example 171 | US9815850, Compound 171 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2ncn(Cc3cccc(c3)C#N)n2)C1=O
Show InChI InChI=1S/C20H17N7O3/c1-26-18-16(6-3-7-22-18)30-11-15(20(26)29)24-19(28)17-23-12-27(25-17)10-14-5-2-4-13(8-14)9-21/h2-8,12,15H,10-11H2,1H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356441
PNG
(US10604535, Example 172 | US9815850, Compound 172 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncn(Cc2cccc(c2)C#N)n1
Show InChI InChI=1S/C21H19N7O3/c1-13-17(21(30)27(2)19-16(31-13)7-4-8-23-19)25-20(29)18-24-12-28(26-18)11-15-6-3-5-14(9-15)10-22/h3-9,12-13,17H,11H2,1-2H3,(H,25,29)/t13-,17+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356394
PNG
(US10604535, Example 174 | US9815850, Compound 134 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C20H19N5O4/c1-12-16(20(27)25(2)17-14(28-12)9-6-10-21-17)22-18(26)19-24-23-15(29-19)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,22,26)/t12-,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356448
PNG
(US10604535, Example 178A | US9815850, Compound 178...)
Show SMILES CN1c2nccnc2CC[C@H](NC(=O)c2nn(Cc3ccccc3F)cc2F)C1=O
Show InChI InChI=1S/C20H18F2N6O2/c1-27-18-15(23-8-9-24-18)6-7-16(20(27)30)25-19(29)17-14(22)11-28(26-17)10-12-4-2-3-5-13(12)21/h2-5,8-9,11,16H,6-7,10H2,1H3,(H,25,29)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356462
PNG
(US10604535, Example 190 | US9815850, Compound 190 ...)
Show SMILES CN1c2nccnc2CC[C@H](NC(=O)c2nnc(Cc3ccccc3)o2)C1=O
Show InChI InChI=1S/C19H18N6O3/c1-25-16-13(20-9-10-21-16)7-8-14(19(25)27)22-17(26)18-24-23-15(28-18)11-12-5-3-2-4-6-12/h2-6,9-10,14H,7-8,11H2,1H3,(H,22,26)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356485
PNG
(US10604535, Example 220 | US9815850, Compound 220 ...)
Show SMILES COc1cccc(Cn2cc(F)c(n2)C(=O)N[C@H]2COc3ccccc3N(C)C2=O)n1
Show InChI InChI=1S/C21H20FN5O4/c1-26-16-7-3-4-8-17(16)31-12-15(21(26)29)24-20(28)19-14(22)11-27(25-19)10-13-6-5-9-18(23-13)30-2/h3-9,11,15H,10,12H2,1-2H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356492
PNG
(US10604535, Example 227 | US9815850, Compound 227 ...)
Show SMILES CN1c2nccnc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2ncc(o2)C(F)(F)c2ccccc2)C1=O
Show InChI InChI=1S/C21H17F2N5O3/c1-28-17-15(24-7-8-25-17)12-9-13(12)16(20(28)30)27-18(29)19-26-10-14(31-19)21(22,23)11-5-3-2-4-6-11/h2-8,10,12-13,16H,9H2,1H3,(H,27,29)/t12-,13+,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356248
PNG
(US10604535, Example 12B | US9815850, Compound 12B ...)
Show SMILES CN1c2ccccc2[C@H](F)C[C@@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356250
PNG
(US10604535, Example 14 | US9815850, Compound 14 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc(CC(F)(F)F)on2)C1=O
Show InChI InChI=1S/C16H14F3N3O4/c1-22-12-4-2-3-5-13(12)25-8-11(15(22)24)20-14(23)10-6-9(26-21-10)7-16(17,18)19/h2-6,11H,7-8H2,1H3,(H,20,23)/t11-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356278
PNG
(US10604535, Example 50A | US9815850, Compound 50A ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)C2C[C@H]2Cc2ccccc2)C1=O
Show InChI InChI=1S/C21H22N2O3/c1-23-18-9-5-6-10-19(18)26-13-17(21(23)25)22-20(24)16-12-15(16)11-14-7-3-2-4-8-14/h2-10,15-17H,11-13H2,1H3,(H,22,24)/t15-,16?,17+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356284
PNG
(US10604535, Example 55 | US9815850, Compound 55 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccn3)cc2F)C1=O
Show InChI InChI=1S/C20H18FN5O3/c1-25-16-7-2-3-8-17(16)29-12-15(20(25)28)23-19(27)18-14(21)11-26(24-18)10-13-6-4-5-9-22-13/h2-9,11,15H,10,12H2,1H3,(H,23,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356292
PNG
(US10604535, Example 62 | US9815850, Compound 62 | ...)
Show SMILES O=C(N[C@H]1COc2cccnc2NC1=O)c1cc(on1)C1(CC1)c1ccccc1
Show InChI InChI=1S/C21H18N4O4/c26-19(23-15-12-28-16-7-4-10-22-18(16)24-20(15)27)14-11-17(29-25-14)21(8-9-21)13-5-2-1-3-6-13/h1-7,10-11,15H,8-9,12H2,(H,23,26)(H,22,24,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356314
PNG
(US10604535, Example 78 | US9815850, Compound 78 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc([nH]2)C2(CC2)c2ccccc2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356325
PNG
(US10604535, Example 85 | US9815850, Compound 85 | ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)s2)C1=O
Show InChI InChI=1S/C19H17N5O3S/c1-24-16-14(8-5-9-20-16)27-11-13(19(24)26)21-17(25)18-23-22-15(28-18)10-12-6-3-2-4-7-12/h2-9,13H,10-11H2,1H3,(H,21,25)/t13-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356333
PNG
(US10604535, Example 91 | US9815850, Compound 91 | ...)
Show SMILES O=C(N[C@H]1COc2cccnc2NC1=O)c1cc([nH]n1)C1(CC1)c1ccccc1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356343
PNG
(US10604535, Example 100B | US9815850, Compound 100...)
Show SMILES CN1c2ncccc2[C@H]2C[C@H]2[C@@H](NC(=O)c2cc(Oc3ccccc3F)ccn2)C1=O
Show InChI InChI=1S/C23H19FN4O3/c1-28-21-14(5-4-9-26-21)15-12-16(15)20(23(28)30)27-22(29)18-11-13(8-10-25-18)31-19-7-3-2-6-17(19)24/h2-11,15-16,20H,12H2,1H3,(H,27,29)/t15-,16-,20-/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356345
PNG
(US10604535, Example 101B | US9815850, Compound 101...)
Show SMILES CN1c2cnn(C)c2CC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356351
PNG
(US10604535, Example 104B | US9815850, Compound 104...)
Show SMILES Cn1cc2NC(=O)[C@H](CCc2n1)NC(=O)c1nnc(Cc2ccccc2)[nH]1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356374
PNG
(US10604535, Example 119B | US9815850, Compound 119...)
Show SMILES CN1c2nccnc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356395
PNG
(US10604535, Example 135 | US9815850, Compound 135 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cccc(F)c3)cc2F)C1=O
Show InChI InChI=1S/C20H17F2N5O3/c1-26-18-16(6-3-7-23-18)30-11-15(20(26)29)24-19(28)17-14(22)10-27(25-17)9-12-4-2-5-13(21)8-12/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)(8-327)


(Homo sapiens (Human))
BDBM356412
PNG
(US10604535, Example 149 | US9815850, Compound 149 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(Oc3ccccc3F)cnn2)C1=O
Show InChI InChI=1S/C20H16FN5O4/c1-26-18-17(7-4-8-22-18)29-11-15(20(26)28)24-19(27)14-9-12(10-23-25-14)30-16-6-3-2-5-13(16)21/h2-10,15H,11H2,1H3,(H,24,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...


US Patent US10604535 (2020)

More data for this
Ligand-Target Pair
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