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Patent code US10604536

Compile Data Set for Download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397977
PNG
(US10604536, Compound 50 | US9994590, Compound 49)
Show SMILES COc1cc(F)cn2c(C)c(nc12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H19FN6O/c1-9-7-21-10(2)18-23-17(24-26(9)18)14-6-13(14)16-11(3)25-8-12(20)5-15(27-4)19(25)22-16/h5,7-8,13-14H,6H2,1-4H3/t13-,14-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397792
PNG
(US10604536, Compound 1 | US9994590, Compound 1)
Show SMILES Cc1c(nc2c3cccnc3ccn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C21H19N7/c1-11-10-23-12(2)20-25-19(26-28(11)20)16-9-15(16)18-13(3)27-8-6-17-14(21(27)24-18)5-4-7-22-17/h4-8,10,15-16H,9H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397931
PNG
(US10604536, Compound 3 | US9994590, Compound 3)
Show SMILES Cc1c(nc2c3ccccc3ccn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C22H20N6/c1-12-11-23-13(2)21-25-20(26-28(12)21)18-10-17(18)19-14(3)27-9-8-15-6-4-5-7-16(15)22(27)24-19/h4-9,11,17-18H,10H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397955
PNG
(US10604536, Compound 27 | US9994590, Compound 27)
Show SMILES Cc1c(nc2c3cccnc3ccn12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C21H19N7/c1-11-10-23-12(2)20-25-19(26-28(11)20)16-9-15(16)18-13(3)27-8-6-17-14(21(27)24-18)5-4-7-22-17/h4-8,10,15-16H,9H2,1-3H3/t15-,16-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397957
PNG
(US10604536, Compound 29 | US9994590, Compound 29)
Show SMILES Cc1cnc(C)c2nc(nn12)[C@@H]1C[C@H]1c1nc2c(ccc3ncccc23)n1C
Show InChI InChI=1S/C21H19N7/c1-11-10-23-12(2)20-25-19(26-28(11)20)14-9-15(14)21-24-18-13-5-4-8-22-16(13)6-7-17(18)27(21)3/h4-8,10,14-15H,9H2,1-3H3/t14-,15-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397949
PNG
(US10604536, Compound 21 | US9994590, Compound 21)
Show SMILES Cn1c(nc2c1ccc1ncccc21)[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18N4/c1-27-21-11-10-19-15(6-4-12-24-19)22(21)26-23(27)17-13-16(17)20-9-8-14-5-2-3-7-18(14)25-20/h2-12,16-17H,13H2,1H3/t16-,17-/m0/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397983
PNG
(US10604536, Compound 55 | US9994590, Compound 55)
Show SMILES COc1cccn2c(F)c(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H17FN6O/c1-9-8-20-10(2)17-22-16(23-25(9)17)12-7-11(12)14-15(19)24-6-4-5-13(26-3)18(24)21-14/h4-6,8,11-12H,7H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397967
PNG
(US10604536, Compound 39 | US9994590, Compound 39)
Show SMILES Cc1cnc(C)c2nc(nn12)C1CC1c1cn2ccc3OCCOc3c2n1
Show InChI InChI=1S/C19H18N6O2/c1-10-8-20-11(2)18-22-17(23-25(10)18)13-7-12(13)14-9-24-4-3-15-16(19(24)21-14)27-6-5-26-15/h3-4,8-9,12-13H,5-7H2,1-2H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397945
PNG
(US10604536, Compound 17 | US9994590, Compound 17)
Show SMILES CCOc1cccn2cc(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H20N6O/c1-4-26-16-6-5-7-24-10-15(21-19(16)24)13-8-14(13)17-22-18-12(3)20-9-11(2)25(18)23-17/h5-7,9-10,13-14H,4,8H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397965
PNG
(US10604536, Compound 37 | US9994590, Compound 37)
Show SMILES COc1cc(OC)c2nc(C3CC3c3nc4c(C)ncc(C)n4n3)c(C)n2c1
Show InChI InChI=1S/C20H22N6O2/c1-10-8-21-11(2)19-23-18(24-26(10)19)15-7-14(15)17-12(3)25-9-13(27-4)6-16(28-5)20(25)22-17/h6,8-9,14-15H,7H2,1-5H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397933
PNG
(US10604536, Compound 5 | US9994590, Compound 5)
Show SMILES Cc1c(nc2c(cccn12)C1CC1)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C21H22N6/c1-11-10-22-12(2)20-24-19(25-27(11)20)17-9-16(17)18-13(3)26-8-4-5-15(14-6-7-14)21(26)23-18/h4-5,8,10,14,16-17H,6-7,9H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397960
PNG
(US10604536, Compound 32 | US9994590, Compound 32)
Show SMILES CCOc1cccn2c(C)c(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C20H22N6O/c1-5-27-16-7-6-8-25-13(4)17(22-20(16)25)14-9-15(14)18-23-19-12(3)21-10-11(2)26(19)24-18/h6-8,10,14-15H,5,9H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397984
PNG
(US10604536, Compound 57 | US9994590, Compound 56)
Show SMILES COc1cccn2c(F)c(nc12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H17FN6O/c1-9-8-20-10(2)17-22-16(23-25(9)17)12-7-11(12)14-15(19)24-6-4-5-13(26-3)18(24)21-14/h4-6,8,11-12H,7H2,1-3H3/t11-,12-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397976
PNG
(US10604536, Compound 48 | US9994590, Compound 48)
Show SMILES Cc1cnc(C)c2nc(nn12)C1CC1c1nc2c3OCCOc3ccn2c1F
Show InChI InChI=1S/C19H17FN6O2/c1-9-8-21-10(2)18-23-17(24-26(9)18)12-7-11(12)14-16(20)25-4-3-13-15(19(25)22-14)28-6-5-27-13/h3-4,8,11-12H,5-7H2,1-2H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397972
PNG
(US10604536, Compound 44 | US9994590, Compound 44)
Show SMILES COc1cc(C)cn2c(F)c(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H19FN6O/c1-9-5-14(27-4)19-22-15(16(20)25(19)8-9)12-6-13(12)17-23-18-11(3)21-7-10(2)26(18)24-17/h5,7-8,12-13H,6H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397962
PNG
(US10604536, Compound 34 | US9994590, Compound 34)
Show SMILES COc1cc(F)cn2c(C)c(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H19FN6O/c1-9-7-21-10(2)18-23-17(24-26(9)18)14-6-13(14)16-11(3)25-8-12(20)5-15(27-4)19(25)22-16/h5,7-8,13-14H,6H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397964
PNG
(US10604536, Compound 36 | US9994590, Compound 36)
Show SMILES COc1cc(C)cn2c(C)c(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C20H22N6O/c1-10-6-16(27-5)20-22-17(13(4)25(20)9-10)14-7-15(14)18-23-19-12(3)21-8-11(2)26(19)24-18/h6,8-9,14-15H,7H2,1-5H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397981
PNG
(US10604536, Compound 54 | US9994590, Compound 53)
Show SMILES COc1cc(C)cn2c(C)c(nc12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C20H22N6O/c1-10-6-16(27-5)20-22-17(13(4)25(20)9-10)14-7-15(14)18-23-19-12(3)21-8-11(2)26(19)24-18/h6,8-9,14-15H,7H2,1-5H3/t14-,15-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397963
PNG
(US10604536, Compound 35 | US9994590, Compound 35)
Show SMILES Cc1c(nc2c3OCCOc3ccn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C20H20N6O2/c1-10-9-21-11(2)19-23-18(24-26(10)19)14-8-13(14)16-12(3)25-5-4-15-17(20(25)22-16)28-7-6-27-15/h4-5,9,13-14H,6-8H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397943
PNG
(US10604536, Compound 15 | US9994590, Compound 15)
Show SMILES COc1cccn2c(C)c(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H20N6O/c1-10-9-20-11(2)18-22-17(23-25(10)18)14-8-13(14)16-12(3)24-7-5-6-15(26-4)19(24)21-16/h5-7,9,13-14H,8H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397979
PNG
(US10604536, Compound 52 | US9994590, Compound 51)
Show SMILES Cc1cnc(C)c2nc(nn12)[C@@H]1C[C@H]1c1nc(cn1C)-c1ccccc1
Show InChI InChI=1S/C20H20N6/c1-12-10-21-13(2)19-23-18(24-26(12)19)15-9-16(15)20-22-17(11-25(20)3)14-7-5-4-6-8-14/h4-8,10-11,15-16H,9H2,1-3H3/t15-,16-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397947
PNG
(US10604536, Compound 19 | US9994590, Compound 19)
Show SMILES Cc1cnc(C)c2nc(nn12)C1CC1c1nc(cn1C)-c1ccccc1
Show InChI InChI=1S/C20H20N6/c1-12-10-21-13(2)19-23-18(24-26(12)19)15-9-16(15)20-22-17(11-25(20)3)14-7-5-4-6-8-14/h4-8,10-11,15-16H,9H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397958
PNG
(US10604536, Compound 30 | US9994590, Compound 30)
Show SMILES Cc1c(nc2c3cccc(F)c3ccn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C22H19FN6/c1-11-10-24-12(2)21-26-20(27-29(11)21)17-9-16(17)19-13(3)28-8-7-14-15(22(28)25-19)5-4-6-18(14)23/h4-8,10,16-17H,9H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397961
PNG
(US10604536, Compound 33 | US9994590, Compound 33)
Show SMILES Cc1c(nc2cc(C)c(F)cn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H19FN6/c1-9-5-16-22-17(12(4)25(16)8-15(9)20)13-6-14(13)18-23-19-11(3)21-7-10(2)26(19)24-18/h5,7-8,13-14H,6H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397951
PNG
(US10604536, Compound 23 | US9994590, Compound 23)
Show SMILES Clc1cccn2cc(nc12)C1CCC1c1cn2cccc(Cl)c2n1
Show InChI InChI=1S/C18H14Cl2N4/c19-13-3-1-7-23-9-15(21-17(13)23)11-5-6-12(11)16-10-24-8-2-4-14(20)18(24)22-16/h1-4,7-12H,5-6H2
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397941
PNG
(US10604536, Compound 13 | US9994590, Compound 13)
Show SMILES COc1ccn2c(C)c(nc2c1)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H20N6O/c1-10-9-20-11(2)19-22-18(23-25(10)19)15-8-14(15)17-12(3)24-6-5-13(26-4)7-16(24)21-17/h5-7,9,14-15H,8H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397966
PNG
(US10604536, Compound 38 | US9994590, Compound 38)
Show SMILES Cc1cnc(C)c2nc(nn12)C1CCC1c1cn2ccc3OCCOc3c2n1
Show InChI InChI=1S/C20H20N6O2/c1-11-9-21-12(2)19-23-18(24-26(11)19)14-4-3-13(14)15-10-25-6-5-16-17(20(25)22-15)28-8-7-27-16/h5-6,9-10,13-14H,3-4,7-8H2,1-2H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397979
PNG
(US10604536, Compound 52 | US9994590, Compound 51)
Show SMILES Cc1cnc(C)c2nc(nn12)[C@@H]1C[C@H]1c1nc(cn1C)-c1ccccc1
Show InChI InChI=1S/C20H20N6/c1-12-10-21-13(2)19-23-18(24-26(12)19)15-9-16(15)20-22-17(11-25(20)3)14-7-5-4-6-8-14/h4-8,10-11,15-16H,9H2,1-3H3/t15-,16-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397977
PNG
(US10604536, Compound 50 | US9994590, Compound 49)
Show SMILES COc1cc(F)cn2c(C)c(nc12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H19FN6O/c1-9-7-21-10(2)18-23-17(24-26(9)18)14-6-13(14)16-11(3)25-8-12(20)5-15(27-4)19(25)22-16/h5,7-8,13-14H,6H2,1-4H3/t13-,14-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397974
PNG
(US10604536, Compound 46 | US9994590, Compound 46)
Show SMILES COc1cccc2n(C)c(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H20N6O/c1-10-9-20-11(2)18-22-17(23-25(10)18)12-8-13(12)19-21-16-14(24(19)3)6-5-7-15(16)26-4/h5-7,9,12-13H,8H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397987
PNG
(US10604536, Compound 59 | US9994590, Compound 59)
Show SMILES COc1cccn2cc(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H18N6O/c1-10-8-19-11(2)17-21-16(22-24(10)17)13-7-12(13)14-9-23-6-4-5-15(25-3)18(23)20-14/h4-6,8-9,12-13H,7H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397969
PNG
(US10604536, Compound 41 | US9994590, Compound 41)
Show SMILES Cc1c(nc2c3cccnc3ccn12)C1CCC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C22H21N7/c1-12-11-24-13(2)21-26-20(27-29(12)21)16-7-6-15(16)19-14(3)28-10-8-18-17(22(28)25-19)5-4-9-23-18/h4-5,8-11,15-16H,6-7H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397981
PNG
(US10604536, Compound 54 | US9994590, Compound 53)
Show SMILES COc1cc(C)cn2c(C)c(nc12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C20H22N6O/c1-10-6-16(27-5)20-22-17(13(4)25(20)9-10)14-7-15(14)18-23-19-12(3)21-8-11(2)26(19)24-18/h6,8-9,14-15H,7H2,1-5H3/t14-,15-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397975
PNG
(US10604536, Compound 47 | US9994590, Compound 47)
Show SMILES COc1cccc2[nH]c(nc12)C1CC1c1nc2c(C)ncc(C)n2n1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397959
PNG
(US10604536, Compound 31 | US9994590, Compound 31)
Show SMILES Cc1c(nc2c(OC(F)F)cccn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H18F2N6O/c1-9-8-22-10(2)17-24-16(25-27(9)17)13-7-12(13)15-11(3)26-6-4-5-14(18(26)23-15)28-19(20)21/h4-6,8,12-13,19H,7H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397956
PNG
(US10604536, Compound 28 | US9994590, Compound 28)
Show SMILES Cc1cnc(C)c2nc(nn12)[C@H]1C[C@@H]1c1nc2c(ccc3ncccc23)n1C
Show InChI InChI=1S/C21H19N7/c1-11-10-23-12(2)20-25-19(26-28(11)20)14-9-15(14)21-24-18-13-5-4-8-22-16(13)6-7-17(18)27(21)3/h4-8,10,14-15H,9H2,1-3H3/t14-,15-/m0/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397934
PNG
(US10604536, Compound 6 | US9994590, Compound 6)
Show SMILES Cc1c(nc2cc(C)ccn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H20N6/c1-10-5-6-24-13(4)17(21-16(24)7-10)14-8-15(14)18-22-19-12(3)20-9-11(2)25(19)23-18/h5-7,9,14-15H,8H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397954
PNG
(US10604536, Compound 26 | US9994590, Compound 26)
Show SMILES Cc1c(nc2c3cccnc3ccn12)[C@H]1C[C@@H]1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C21H19N7/c1-11-10-23-12(2)20-25-19(26-28(11)20)16-9-15(16)18-13(3)27-8-6-17-14(21(27)24-18)5-4-7-22-17/h4-8,10,15-16H,9H2,1-3H3/t15-,16-/m0/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397950
PNG
(US10604536, Compound 22 | US9994590, Compound 22)
Show SMILES Cn1c(nc2c1ccc1ncccc21)[C@@H]1C[C@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18N4/c1-27-21-11-10-19-15(6-4-12-24-19)22(21)26-23(27)17-13-16(17)20-9-8-14-5-2-3-7-18(14)25-20/h2-12,16-17H,13H2,1H3/t16-,17-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397948
PNG
(US10604536, Compound 20 | US9994590, Compound 20)
Show SMILES Cn1c(nc2c1ccc1ncccc21)C1CC1c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18N4/c1-27-21-11-10-19-15(6-4-12-24-19)22(21)26-23(27)17-13-16(17)20-9-8-14-5-2-3-7-18(14)25-20/h2-12,16-17H,13H2,1H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397984
PNG
(US10604536, Compound 57 | US9994590, Compound 56)
Show SMILES COc1cccn2c(F)c(nc12)[C@@H]1C[C@H]1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H17FN6O/c1-9-8-20-10(2)17-22-16(23-25(9)17)12-7-11(12)14-15(19)24-6-4-5-13(26-3)18(24)21-14/h4-6,8,11-12H,7H2,1-3H3/t11-,12-/m1/s1
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397946
PNG
(US10604536, Compound 18 | US9994590, Compound 18)
Show SMILES Cc1cc2nc(cn2cc1F)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H17FN6/c1-9-4-16-21-15(8-24(16)7-14(9)19)12-5-13(12)17-22-18-11(3)20-6-10(2)25(18)23-17/h4,6-8,12-13H,5H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397953
PNG
(US10604536, Compound 25 | US9994590, Compound 25)
Show SMILES Cn1c(nc2c1ccc1ncccc21)C1CCC1c1nc2c(ccc3ncccc23)n1C
Show InChI InChI=1S/C26H22N6/c1-31-21-11-9-19-17(5-3-13-27-19)23(21)29-25(31)15-7-8-16(15)26-30-24-18-6-4-14-28-20(18)10-12-22(24)32(26)2/h3-6,9-16H,7-8H2,1-2H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397940
PNG
(US10604536, Compound 12 | US9994590, Compound 12)
Show SMILES Cc1ccn2cc(nc2c1)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H18N6/c1-10-4-5-23-9-15(20-16(23)6-10)13-7-14(13)17-21-18-12(3)19-8-11(2)24(18)22-17/h4-6,8-9,13-14H,7H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397932
PNG
(US10604536, Compound 4 | US9994590, Compound 4)
Show SMILES Cc1c(nc2cc(F)ccn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H17FN6/c1-9-8-20-10(2)18-22-17(23-25(9)18)14-7-13(14)16-11(3)24-5-4-12(19)6-15(24)21-16/h4-6,8,13-14H,7H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397970
PNG
(US10604536, Compound 42 | US9994590, Compound 42)
Show SMILES COc1cccn2c(C)c(nc12)C1CCC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C20H22N6O/c1-11-10-21-12(2)19-23-18(24-26(11)19)15-8-7-14(15)17-13(3)25-9-5-6-16(27-4)20(25)22-17/h5-6,9-10,14-15H,7-8H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397939
PNG
(US10604536, Compound 11 | US9994590, Compound 11)
Show SMILES Clc1cccn2cc(nc12)C1CC1c1cn2cccc(Cl)c2n1
Show InChI InChI=1S/C17H12Cl2N4/c18-12-3-1-5-22-8-14(20-16(12)22)10-7-11(10)15-9-23-6-2-4-13(19)17(23)21-15/h1-6,8-11H,7H2
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397968
PNG
(US10604536, Compound 40 | US9994590, Compound 40)
Show SMILES Cc1cnc(C)c2nc(nn12)C1CCC1c1nc2c(ccc3ncccc23)n1C
Show InChI InChI=1S/C22H21N7/c1-12-11-24-13(2)21-26-20(27-29(12)21)14-6-7-15(14)22-25-19-16-5-4-10-23-17(16)8-9-18(19)28(22)3/h4-5,8-11,14-15H,6-7H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397938
PNG
(US10604536, Compound 10 | US9994590, Compound 10)
Show SMILES Fc1cccn2cc(nc12)C1CC1c1cn2cccc(F)c2n1
Show InChI InChI=1S/C17H12F2N4/c18-12-3-1-5-22-8-14(20-16(12)22)10-7-11(10)15-9-23-6-2-4-13(19)17(23)21-15/h1-6,8-11H,7H2
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397973
PNG
(US10604536, Compound 45 | US9994590, Compound 45)
Show SMILES Cc1cnc(C)c2nc(cn12)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H19N7/c1-9-6-19-11(3)17-21-15(8-24(9)17)13-5-14(13)16-22-18-12(4)20-7-10(2)25(18)23-16/h6-8,13-14H,5H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397936
PNG
(US10604536, Compound 8 | US9994590, Compound 8)
Show SMILES Cc1cccn2cc(nc12)C1CC1c1cn2cccc(C)c2n1
Show InChI InChI=1S/C19H18N4/c1-12-5-3-7-22-10-16(20-18(12)22)14-9-15(14)17-11-23-8-4-6-13(2)19(23)21-17/h3-8,10-11,14-15H,9H2,1-2H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397952
PNG
(US10604536, Compound 58 | US9994590, Compound 24)
Show SMILES Fc1ccn2cc(nc2c1)C1CCC1c1cn2cccc(Cl)c2n1
Show InChI InChI=1S/C18H14ClFN4/c19-14-2-1-6-24-10-16(22-18(14)24)13-4-3-12(13)15-9-23-7-5-11(20)8-17(23)21-15/h1-2,5-10,12-13H,3-4H2
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397937
PNG
(US10604536, Compound 9 | US9994590, Compound 9)
Show SMILES Fc1ccn2cc(nc2c1)C1CC1c1cn2ccc(F)cc2n1
Show InChI InChI=1S/C17H12F2N4/c18-10-1-3-22-8-14(20-16(22)5-10)12-7-13(12)15-9-23-4-2-11(19)6-17(23)21-15/h1-6,8-9,12-13H,7H2
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397942
PNG
(US10604536, Compound 14 | US9994590, Compound 14)
Show SMILES CCOc1ccn2c(C)c(nc2c1)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C20H22N6O/c1-5-27-14-6-7-25-13(4)18(22-17(25)8-14)15-9-16(15)19-23-20-12(3)21-10-11(2)26(20)24-19/h6-8,10,15-16H,5,9H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397935
PNG
(US10604536, Compound 7 | US9994590, Compound 7)
Show SMILES Cc1c(nc2cc(C)ccn12)C1CC1c1cn2ccc(F)cc2n1
Show InChI InChI=1S/C19H17FN4/c1-11-3-6-24-12(2)19(22-18(24)7-11)15-9-14(15)16-10-23-5-4-13(20)8-17(23)21-16/h3-8,10,14-15H,9H2,1-2H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397930
PNG
(US10604536, Compound 2 | US9994590, Compound 2)
Show SMILES COc1ccn2cc(nc2c1C)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C19H20N6O/c1-10-8-20-12(3)19-22-17(23-25(10)19)14-7-13(14)15-9-24-6-5-16(26-4)11(2)18(24)21-15/h5-6,8-9,13-14H,7H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397952
PNG
(US10604536, Compound 58 | US9994590, Compound 24)
Show SMILES Fc1ccn2cc(nc2c1)C1CCC1c1cn2cccc(Cl)c2n1
Show InChI InChI=1S/C18H14ClFN4/c19-14-2-1-6-24-10-16(22-18(14)24)13-4-3-12(13)15-9-23-7-5-11(20)8-17(23)21-15/h1-2,5-10,12-13H,3-4H2
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397944
PNG
(US10604536, Compound 16 | US9994590, Compound 16)
Show SMILES COc1ccn2cc(nc2c1)C1CC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C18H18N6O/c1-10-8-19-11(2)18-21-17(22-24(10)18)14-7-13(14)15-9-23-5-4-12(25-3)6-16(23)20-15/h4-6,8-9,13-14H,7H2,1-3H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM397971
PNG
(US10604536, Compound 43 | US9994590, Compound 43)
Show SMILES COc1ccn2c(C)c(nc2c1)C1CCC1c1nc2c(C)ncc(C)n2n1
Show InChI InChI=1S/C20H22N6O/c1-11-10-21-12(2)20-23-19(24-26(11)20)16-6-5-15(16)18-13(3)25-8-7-14(27-4)9-17(25)22-18/h7-10,15-16H,5-6H2,1-4H3
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Sunovion Pharamaceuticals Inc.

US Patent


Assay Description
The compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 enzyme expressed in...

US Patent US10604536 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%