BindingDB logo
myBDB logout

Patent code US10611730

Compile Data Set for Download or QSAR

Found 212 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436039
PNG
(6-(2-Chloro-6-(trifluoromethoxy)phenyl)-4-methyl-1...)
Show SMILES Cc1cc(cc2[nH]c(=O)[nH]c12)-c1c(Cl)cccc1OC(F)(F)F
Show InChI InChI=1S/C15H10ClF3N2O2/c1-7-5-8(6-10-13(7)21-14(22)20-10)12-9(16)3-2-4-11(12)23-15(17,18)19/h2-6H,1H3,(H2,20,21,22)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM50459021
PNG
(CHEMBL4212408 | US10611730, Example 76)
Show SMILES FC(F)(F)Oc1cccc(Cl)c1-c1ccc2[nH]c(=O)sc2c1
Show InChI InChI=1S/C14H7ClF3NO2S/c15-8-2-1-3-10(21-14(16,17)18)12(8)7-4-5-9-11(6-7)22-13(20)19-9/h1-6H,(H,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436042
PNG
(6-(2-Chloro-6-(trifluoromethoxy)phenyl)-4-fluoro-1...)
Show SMILES Fc1cc(cc2[nH]c(=O)[nH]c12)-c1c(Cl)cccc1OC(F)(F)F
Show InChI InChI=1S/C14H7ClF4N2O2/c15-7-2-1-3-10(23-14(17,18)19)11(7)6-4-8(16)12-9(5-6)20-13(22)21-12/h1-5H,(H2,20,21,22)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435960
PNG
(2-[3-Chloro-2-(2-oxo-3H-1,3-benzothiazol-6-yl)phen...)
Show SMILES Clc1cccc(CC#N)c1-c1ccc2[nH]c(=O)sc2c1
Show InChI InChI=1S/C15H9ClN2OS/c16-11-3-1-2-9(6-7-17)14(11)10-4-5-12-13(8-10)20-15(19)18-12/h1-5,8H,6H2,(H,18,19)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435917
PNG
(5-[2-(Cyclopropylmethoxy)-6-(trifluoromethoxy)phen...)
Show SMILES FC(F)(F)Oc1cccc(OCC2CC2)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)26-15-3-1-2-14(25-9-10-4-5-10)16(15)11-6-7-12-13(8-11)23-17(24)22-12/h1-3,6-8,10H,4-5,9H2,(H2,22,23,24)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM50459028
PNG
(CHEMBL4216045 | US10611730, Example 160)
Show SMILES Clc1cccc(C2CC2)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C16H13ClN2O/c17-12-3-1-2-11(9-4-5-9)15(12)10-6-7-13-14(8-10)19-16(20)18-13/h1-3,6-9H,4-5H2,(H2,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436013
PNG
(US10611730, Example 186 | tert-Butyl 5-[2-chloro-3...)
Show SMILES CC(C)(C)OC(=O)N1CCC=C(C1)c1cccc(-c2ccc3[nH]c(=O)[nH]c3c2)c1Cl
Show InChI InChI=1S/C23H24ClN3O3/c1-23(2,3)30-22(29)27-11-5-6-15(13-27)17-8-4-7-16(20(17)24)14-9-10-18-19(12-14)26-21(28)25-18/h4,6-10,12H,5,11,13H2,1-3H3,(H2,25,26,28)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM50459026
PNG
(CHEMBL4214902 | US10611730, Example 31)
Show SMILES FC(F)(F)Oc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C14H8ClF3N2O2/c15-8-2-1-3-11(22-14(16,17)18)12(8)7-4-5-9-10(6-7)20-13(21)19-9/h1-6H,(H2,19,20,21)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435916
PNG
(5-[2-Isopropoxy-6-(trifluoromethoxy)phenyl]-1,3-di...)
Show SMILES CC(C)Oc1cccc(OC(F)(F)F)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C17H15F3N2O3/c1-9(2)24-13-4-3-5-14(25-17(18,19)20)15(13)10-6-7-11-12(8-10)22-16(23)21-11/h3-9H,1-2H3,(H2,21,22,23)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435950
PNG
(2-[3,4-Dichloro-2-(2-oxo-1,3-dihydrobenzimidazol-5...)
Show SMILES Clc1ccc(CC#N)c(c1Cl)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C15H9Cl2N3O/c16-10-3-1-8(5-6-18)13(14(10)17)9-2-4-11-12(7-9)20-15(21)19-11/h1-4,7H,5H2,(H2,19,20,21)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 7.94n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435894
PNG
(5-(2,3,6-Trichlorophenyl)-1,3-dihydrobenzimidazol-...)
Show SMILES Clc1ccc(Cl)c(-c2ccc3[nH]c(=O)[nH]c3c2)c1Cl
Show InChI InChI=1S/C13H7Cl3N2O/c14-7-2-3-8(15)12(16)11(7)6-1-4-9-10(5-6)18-13(19)17-9/h1-5H,(H2,17,18,19)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436029
PNG
(5-(3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-2-methyl...)
Show SMILES Cc1c(cccc1-c1ccc2[nH]c(=O)[nH]c2c1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C19H16N4O2/c1-10-13(12-7-8-15-16(9-12)21-19(24)20-15)3-2-4-14(10)18-22-17(23-25-18)11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H2,20,21,24)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435920
PNG
(5-[2-Chloro-6-(cyclopropylmethoxy)phenyl]-1,3-dihy...)
Show SMILES Clc1cccc(OCC2CC2)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C17H15ClN2O2/c18-12-2-1-3-15(22-9-10-4-5-10)16(12)11-6-7-13-14(8-11)20-17(21)19-13/h1-3,6-8,10H,4-5,9H2,(H2,19,20,21)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436015
PNG
(5-[2-Chloro-3-(1-piperidyl)phenyl]-1,3-dihydrobenz...)
Show SMILES Clc1c(cccc1-c1ccc2[nH]c(=O)[nH]c2c1)N1CCCCC1
Show InChI InChI=1S/C18H18ClN3O/c19-17-13(5-4-6-16(17)22-9-2-1-3-10-22)12-7-8-14-15(11-12)21-18(23)20-14/h4-8,11H,1-3,9-10H2,(H2,20,21,23)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435953
PNG
((+-)-2-[3-Chloro-2-(2-oxo-1,3-dihydrobenzimidazol-...)
Show SMILES CC(C#N)c1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C16H10ClN3O/c1-9(8-18)11-3-2-4-12(17)15(11)10-5-6-13-14(7-10)20-16(21)19-13/h2-7,9H,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435905
PNG
(6-(2-Isopropoxy-6-methoxy-phenyl)-3H-1,3-benzothia...)
Show SMILES COc1cccc(OC(C)C)c1-c1ccc2[nH]c(=O)sc2c1
Show InChI InChI=1S/C17H17NO3S/c1-10(2)21-14-6-4-5-13(20-3)16(14)11-7-8-12-15(9-11)22-17(19)18-12/h4-10H,1-3H3,(H,18,19)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM50459030
PNG
(CHEMBL4207238 | US10611730, Example 124)
Show SMILES Clc1cccc(CC#N)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C15H10ClN3O/c16-11-3-1-2-9(6-7-17)14(11)10-4-5-12-13(8-10)19-15(20)18-12/h1-5,8H,6H2,(H2,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435765
PNG
(5-(2,6-Dichloro-3-methyl-phenyl)-1,3-dihydrobenzim...)
Show SMILES Cc1ccc(Cl)c(c1Cl)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C14H10Cl2N2O/c1-7-2-4-9(15)12(13(7)16)8-3-5-10-11(6-8)18-14(19)17-10/h2-6H,1H3,(H2,17,18,19)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 15.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435951
PNG
(2-[2-(2-Oxo-1,3-dihydrobenzimidazol-5-yl)-3-triflu...)
Show SMILES FC(F)(F)Oc1cccc(CC#N)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C16H10F3N3O2/c17-16(18,19)24-13-3-1-2-9(6-7-20)14(13)10-4-5-11-12(8-10)22-15(23)21-11/h1-5,8H,6H2,(H2,21,22,23)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 15.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436037
PNG
(4-Chloro-3-(2-oxo-1,3-dihydrobenzimidazol-5-yl)-2-...)
Show SMILES FC(F)(F)Oc1c(ccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1)C#N
Show InChI InChI=1S/C15H7ClF3N3O2/c16-9-3-1-8(6-20)13(24-15(17,18)19)12(9)7-2-4-10-11(5-7)22-14(23)21-10/h1-5H,(H2,21,22,23)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 15.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436036
PNG
(2-Chloro-3-(2-oxo-1,3-dihydrobenzimidazol-5-yl)-4-...)
Show SMILES FC(F)(F)Oc1ccc(C#N)c(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C15H7ClF3N3O2/c16-13-8(6-20)2-4-11(24-15(17,18)19)12(13)7-1-3-9-10(5-7)22-14(23)21-9/h1-5H,(H2,21,22,23)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 15.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435921
PNG
((+-)-5-[2-Chloro-6-[(2,2-difluorocyclopropyl)metho...)
Show SMILES FC1(F)CC1COc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C17H11ClF2N2O2/c18-11-2-1-3-14(24-8-10-7-17(10,19)20)15(11)9-4-5-12-13(6-9)22-16(23)21-12/h1-6,10H,7-8H2
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435962
PNG
(2-[3-(4-Fluorophenyl)-2-(2-oxo-1,3-dihydrobenzimid...)
Show SMILES Fc1ccc(cc1)-c1cccc(CC#N)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C21H14FN3O/c22-16-7-4-13(5-8-16)17-3-1-2-14(10-11-23)20(17)15-6-9-18-19(12-15)25-21(26)24-18/h1-9,12H,10H2,(H2,24,25,26)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435903
PNG
(5-[2-Methyl-3-[5-(4-pyridyl)-1,2,4-oxadiazol-3-yl]...)
Show SMILES Cc1c(cccc1-c1ccc2[nH]c(=O)[nH]c2c1)-c1noc(n1)-c1ccncc1
Show InChI InChI=1S/C21H15N5O2/c1-12-15(14-5-6-17-18(11-14)24-21(27)23-17)3-2-4-16(12)19-25-20(28-26-19)13-7-9-22-10-8-13/h2-11H,1H3,(H2,23,24,27)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436026
PNG
(5-[2-Methyl-3-[5-(trifluoromethyl)-1,3,4-oxadiazol...)
Show SMILES Cc1c(cccc1-c1ccc2[nH]c(=O)[nH]c2c1)-c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C17H11F3N4O2/c1-8-10(9-5-6-12-13(7-9)22-16(25)21-12)3-2-4-11(8)14-23-24-15(26-14)17(18,19)20/h2-7H,1H3,(H2,21,22,25)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435976
PNG
(5-[3-[(2,2-Dimethylmorpholin-4-yl)methyl]-2-methyl...)
Show SMILES Cc1c(CN2CCOC(C)(C)C2)cccc1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C21H25N3O2/c1-14-16(12-24-9-10-26-21(2,3)13-24)5-4-6-17(14)15-7-8-18-19(11-15)23-20(25)22-18/h4-8,11H,9-10,12-13H2,1-3H3,(H2,22,23,25)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435990
PNG
(5-[2-Chloro-6-(4-fluorophenyl)phenyl]-1,3-dihydrob...)
Show SMILES Fc1ccc(cc1)-c1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C19H12ClFN2O/c20-15-3-1-2-14(11-4-7-13(21)8-5-11)18(15)12-6-9-16-17(10-12)23-19(24)22-16/h1-10H,(H2,22,23,24)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435989
PNG
(5-(2-Chloro-6-phenyl-phenyl)-1,3-dihydrobenzimidaz...)
Show SMILES Clc1cccc(-c2ccccc2)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C19H13ClN2O/c20-15-8-4-7-14(12-5-2-1-3-6-12)18(15)13-9-10-16-17(11-13)22-19(23)21-16/h1-11H,(H2,21,22,23)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435954
PNG
(2-[3-Chloro-2-(2-oxo-1,3-dihydrobenzimidazol-5-yl)...)
Show SMILES CC(C)(C#N)c1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C17H14ClN3O/c1-17(2,9-19)11-4-3-5-12(18)15(11)10-6-7-13-14(8-10)21-16(22)20-13/h3-8H,1-2H3,(H2,20,21,22)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 25.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435978
PNG
((+-)-5-[2-Methyl-3-[[2-(trifluoromethyl)morpholin-...)
Show SMILES Cc1c(CN2CCOC(C2)C(F)(F)F)cccc1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C20H18F3N3O2/c1-12-14(10-26-7-8-28-18(11-26)20(21,22)23)3-2-4-15(12)13-5-6-16-17(9-13)25-19(27)24-16/h2-6,9,18H,7-8,10-11H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436034
PNG
(5-[2-Methyl-3-(1,2,4-oxadiazol-3-yl)phenyl]-1,3-di...)
Show SMILES Cc1c(cccc1-c1ccc2[nH]c(=O)[nH]c2c1)-c1ncon1
Show InChI InChI=1S/C16H12N4O2/c1-9-11(3-2-4-12(9)15-17-8-22-20-15)10-5-6-13-14(7-10)19-16(21)18-13/h2-8H,1H3,(H2,18,19,21)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435756
PNG
(5-(2-Isobutoxy-6-methoxy-phenyl)-1,3-dihydrobenzim...)
Show SMILES COc1cccc(OCC(C)C)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C18H20N2O3/c1-11(2)10-23-16-6-4-5-15(22-3)17(16)12-7-8-13-14(9-12)20-18(21)19-13/h4-9,11H,10H2,1-3H3,(H2,19,20,21)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435772
PNG
(5-[3-Chloro-2-(trifluoromethoxy)phenyl]-1,3-dihydr...)
Show SMILES FC(F)(F)Oc1c(Cl)cccc1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C14H8ClF3N2O2/c15-9-3-1-2-8(12(9)22-14(16,17)18)7-4-5-10-11(6-7)20-13(21)19-10/h1-6H,(H2,19,20,21)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435901
PNG
(5-[3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-2-methyl...)
Show SMILES Cc1c(cccc1-c1ccc2[nH]c(=O)[nH]c2c1)-c1noc(n1)C1CC1
Show InChI InChI=1S/C19H16N4O2/c1-10-13(12-7-8-15-16(9-12)21-19(24)20-15)3-2-4-14(10)17-22-18(25-23-17)11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H2,20,21,24)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435938
PNG
(5-(2-Chloro-3-isopropoxy-phenyl)-1,3-dihydrobenzim...)
Show SMILES CC(C)Oc1cccc(c1Cl)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C16H15ClN2O2/c1-9(2)21-14-5-3-4-11(15(14)17)10-6-7-12-13(8-10)19-16(20)18-12/h3-9H,1-2H3,(H2,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435757
PNG
(5-(2-Isobutoxy-5-methyl-phenyl)-1,3-dihydrobenzimi...)
Show SMILES CC(C)COc1ccc(C)cc1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C18H20N2O2/c1-11(2)10-22-17-7-4-12(3)8-14(17)13-5-6-15-16(9-13)20-18(21)19-15/h4-9,11H,10H2,1-3H3,(H2,19,20,21)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435959
PNG
(2-[3-Bromo-2-(2-oxo-1,3-dihydrobenzimidazol-5-yl)p...)
Show SMILES Brc1cccc(CC#N)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C15H10BrN3O/c16-11-3-1-2-9(6-7-17)14(11)10-4-5-12-13(8-10)19-15(20)18-12/h1-5,8H,6H2,(H2,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435785
PNG
(Methyl 2-chloro-3-(2-oxo-1,3-dihydrobenzimidazol-5...)
Show SMILES COC(=O)c1cccc(c1Cl)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C15H11ClN2O3/c1-21-14(19)10-4-2-3-9(13(10)16)8-5-6-11-12(7-8)18-15(20)17-11/h2-7H,1H3,(H2,17,18,20)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435922
PNG
(5-[2-Chloro-6-(difluoromethoxy)phenyl]-1,3-dihydro...)
Show SMILES FC(F)Oc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C14H9ClF2N2O2/c15-8-2-1-3-11(21-13(16)17)12(8)7-4-5-9-10(6-7)19-14(20)18-9/h1-6,13H,(H2,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435988
PNG
(5-(2-Chloro-6-vinyl-phenyl)-1,3-dihydrobenzimidazo...)
Show SMILES Clc1cccc(C=C)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C15H11ClN2O/c1-2-9-4-3-5-11(16)14(9)10-6-7-12-13(8-10)18-15(19)17-12/h2-8H,1H2,(H2,17,18,19)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435946
PNG
((+-)-5-[2-Chloro-6-(2,2,2-trifluoro-1-methyl-ethox...)
Show SMILES CC(Oc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C16H10ClF3N2O2/c1-8(16(18,19)20)24-13-4-2-3-10(17)14(13)9-5-6-11-12(7-9)22-15(23)21-11/h2-8H,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 31.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435934
PNG
(5-[2-[(4-Fluorophenyl)ethoxy]-6-methoxy-phenyl]-1,...)
Show SMILES COc1cccc(OCc2ccc(F)cc2)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C21H17FN2O3/c1-26-18-3-2-4-19(27-12-13-5-8-15(22)9-6-13)20(18)14-7-10-16-17(11-14)24-21(25)23-16/h2-11H,12H2,1H3,(H2,23,24,25)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435991
PNG
(4-[3-Chloro-2-(2-oxo-1,3-dihydrobenzimidazol-5-yl)...)
Show SMILES Clc1cccc(-c2ccc(cc2)C#N)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C20H12ClN3O/c21-16-3-1-2-15(13-6-4-12(11-22)5-7-13)19(16)14-8-9-17-18(10-14)24-20(25)23-17/h1-10H,(H2,23,24,25)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436031
PNG
(5-[2-Methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)pheny...)
Show SMILES Cc1noc(n1)-c1cccc(-c2ccc3[nH]c(=O)[nH]c3c2)c1C
Show InChI InChI=1S/C17H14N4O2/c1-9-12(4-3-5-13(9)16-18-10(2)21-23-16)11-6-7-14-15(8-11)20-17(22)19-14/h3-8H,1-2H3,(H2,19,20,22)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435937
PNG
(5-[2-Chloro-3-(cyclopropoxy)phenyl]-1,3-dihydroben...)
Show SMILES Clc1c(OC2CC2)cccc1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C16H13ClN2O2/c17-15-11(2-1-3-14(15)21-10-5-6-10)9-4-7-12-13(8-9)19-16(20)18-12/h1-4,7-8,10H,5-6H2,(H2,18,19,20)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435889
PNG
(5-[2-Chloro-3-(trifluoromethyl)phenyl]-1,3-dihydro...)
Show SMILES FC(F)(F)c1cccc(c1Cl)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C14H8ClF3N2O/c15-12-8(2-1-3-9(12)14(16,17)18)7-4-5-10-11(6-7)20-13(21)19-10/h1-6H,(H2,19,20,21)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435933
PNG
(5-(2-Benzyloxy-6-methoxy-phenyl)-1,3-dihydrobenzim...)
Show SMILES COc1cccc(OCc2ccccc2)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C21H18N2O3/c1-25-18-8-5-9-19(26-13-14-6-3-2-4-7-14)20(18)15-10-11-16-17(12-15)23-21(24)22-16/h2-12H,13H2,1H3,(H2,22,23,24)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM436033
PNG
(5-[2-Methyl-3-[3-(trifluoromethyl)-1,2,4-oxadiazol...)
Show SMILES Cc1c(cccc1-c1ccc2[nH]c(=O)[nH]c2c1)-c1nc(no1)C(F)(F)F
Show InChI InChI=1S/C17H11F3N4O2/c1-8-10(9-5-6-12-13(7-9)22-16(25)21-12)3-2-4-11(8)14-23-15(24-26-14)17(18,19)20/h2-7H,1H3,(H2,21,22,25)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435947
PNG
((R*)-5-[2-Chloro-6-(2,2,2-trifluoro-1-methyl-ethox...)
Show SMILES C[C@@H](Oc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C16H10ClF3N2O2/c1-8(16(18,19)20)24-13-4-2-3-10(17)14(13)9-5-6-11-12(7-9)22-15(23)21-11/h2-8H,1H3/t8-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM435926
PNG
(5-[2-Chloro-6-(2,2-dimethylpropoxy)phenyl]-1,3-dih...)
Show SMILES CC(C)(C)COc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C18H19ClN2O2/c1-18(2,3)10-23-15-6-4-5-12(19)16(15)11-7-8-13-14(9-11)21-17(22)20-13/h4-9H,10H2,1-3H3,(H2,20,21,22)
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 50.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10611730 (2020)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 212 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%