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Patent code US10611777

Compile Data Set for Download or QSAR
Found 156 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350391
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350391
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350392
PNG
((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...)
Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350430
PNG
(US10208066, Compound 49 | US10611777, Compound 49)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(O)cc1
Show InChI InChI=1S/C19H15ClN8O/c1-10(26-19-14(7-21)18(22)24-9-25-19)13-6-16-23-8-15(20)28(16)27-17(13)11-2-4-12(29)5-3-11/h2-6,8-10,29H,1H3,(H3,22,24,25,26)/t10-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350438
PNG
(US10208066, Compound 60 | US10611777, Compound 60)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccsc1
Show InChI InChI=1S/C17H13ClN8S/c1-9(24-17-12(5-19)16(20)22-8-23-17)11-4-14-21-6-13(18)26(14)25-15(11)10-2-3-27-7-10/h2-4,6-9H,1H3,(H3,20,22,23,24)/t9-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350430
PNG
(US10208066, Compound 49 | US10611777, Compound 49)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(O)cc1
Show InChI InChI=1S/C19H15ClN8O/c1-10(26-19-14(7-21)18(22)24-9-25-19)13-6-16-23-8-15(20)28(16)27-17(13)11-2-4-12(29)5-3-11/h2-6,8-10,29H,1H3,(H3,22,24,25,26)/t10-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350447
PNG
((S)-4-amino-6-((1-(3-chloro-6-(2-hydroxyphenyl)imi...)
Show SMILES COc1ccccc1-c1nn2c(Cl)cnc2cc1[C@H](C)Nc1ncnc(N)c1C#N
Show InChI InChI=1S/C20H17ClN8O/c1-11(27-20-14(8-22)19(23)25-10-26-20)13-7-17-24-9-16(21)29(17)28-18(13)12-5-3-4-6-15(12)30-2/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350389
PNG
(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Show SMILES CC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)
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n/an/a 1n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350398
PNG
(US10208066, Compound 15 | US10611777, Compound 15)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
Show InChI InChI=1S/C19H14ClFN8/c1-10(27-19-14(7-22)18(23)25-9-26-19)13-6-16-24-8-15(20)29(16)28-17(13)11-3-2-4-12(21)5-11/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350454
PNG
((S)-4-amino-6-(0-(3-fluoro-6-phenylimidazo[1,2-b]p...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(F)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15FN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350402
PNG
(US10208066, Compound 19 | US10611777, Compound 19)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F
Show InChI InChI=1S/C20H16ClFN8/c1-2-15(28-20-13(8-23)19(24)26-10-27-20)12-7-17-25-9-16(21)30(17)29-18(12)11-5-3-4-6-14(11)22/h3-7,9-10,15H,2H2,1H3,(H3,24,26,27,28)
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n/an/a 2n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350405
PNG
(US10208066, Compound 22 | US10611777, Compound 22)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(C)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H18N8/c1-12-10-23-17-8-15(18(27-28(12)17)14-6-4-3-5-7-14)13(2)26-20-16(9-21)19(22)24-11-25-20/h3-8,10-11,13H,1-2H3,(H3,22,24,25,26)/t13-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350443
PNG
(US10208066, Compound 65 | US10611777, Compound 65)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)C#N
Show InChI InChI=1S/C20H14ClN9/c1-11(28-20-15(8-23)19(24)26-10-27-20)14-6-17-25-9-16(21)30(17)29-18(14)13-4-2-3-12(5-13)7-22/h2-6,9-11H,1H3,(H3,24,26,27,28)/t11-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350446
PNG
(US10208066, Compound 68 | US10611777, Compound 68)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1S(C)(=O)=O
Show InChI InChI=1S/C20H17ClN8O2S/c1-11(27-20-14(8-22)19(23)25-10-26-20)13-7-17-24-9-16(21)29(17)28-18(13)12-5-3-4-6-15(12)32(2,30)31/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350396
PNG
(US10208066, Compound 12 | US10611777, Compound 12)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F
Show InChI InChI=1S/C19H14ClFN8/c1-10(27-19-13(7-22)18(23)25-9-26-19)12-6-16-24-8-15(20)29(16)28-17(12)11-4-2-3-5-14(11)21/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436060
PNG
(US10611777, Compound 9)
Show SMILES C[C@@H](Nc1ncnc2[nH]cc(C#N)c12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436131
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES C[C@H](Nc1ncnc(N)c1C(=O)NNC(C)=O)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C21H20ClN9O2/c1-11(27-20-17(19(23)25-10-26-20)21(33)29-28-12(2)32)14-8-16-24-9-15(22)31(16)30-18(14)13-6-4-3-5-7-13/h3-11H,1-2H3,(H,28,32)(H,29,33)(H3,23,25,26,27)/t11-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350453
PNG
(US10208066, Compound 77 | US10611777, Compound 77)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccnc1
Show InChI InChI=1S/C18H14ClN9/c1-10(26-18-13(6-20)17(21)24-9-25-18)12-5-15-23-8-14(19)28(15)27-16(12)11-3-2-4-22-7-11/h2-5,7-10H,1H3,(H3,21,24,25,26)/t10-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350407
PNG
(US10208066, Compound 24 | US10611777, Compound 24)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
Show InChI InChI=1S/C20H16ClFN8/c1-2-15(28-20-14(8-23)19(24)26-10-27-20)13-7-17-25-9-16(21)30(17)29-18(13)11-4-3-5-12(22)6-11/h3-7,9-10,15H,2H2,1H3,(H3,24,26,27,28)
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n/an/a 2n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350421
PNG
(US10208066, Compound 40 | US10611777, Compound 40)
Show SMILES C[C@H](Nc1ncnc(N)c1Cl)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C18H15Cl2N7/c1-10(25-18-15(20)17(21)23-9-24-18)12-7-14-22-8-13(19)27(14)26-16(12)11-5-3-2-4-6-11/h2-10H,1H3,(H3,21,23,24,25)/t10-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350440
PNG
(US10208066, Compound 62 | US10611777, Compound 62)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(C)c1
Show InChI InChI=1S/C20H17ClN8/c1-11-4-3-5-13(6-11)18-14(7-17-24-9-16(21)29(17)28-18)12(2)27-20-15(8-22)19(23)25-10-26-20/h3-7,9-10,12H,1-2H3,(H3,23,25,26,27)/t12-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436129
PNG
((chiral)-4-amino-6-((1-(3-chloro-6-(3-(2-hydroxypr...)
Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)c2cc([C@@H](C)N[S@](=O)C(C)(C)C)c(Cl)nn2)cc1
Show InChI InChI=1S/C26H33ClN4O3S/c1-18(30-35(32)26(2,3)4)23-15-24(28-29-25(23)27)31(16-19-7-11-21(33-5)12-8-19)17-20-9-13-22(34-6)14-10-20/h7-15,18,30H,16-17H2,1-6H3/t18-,35-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350434
PNG
(US10208066, Compound 54 | US10611777, Compound 54)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(O)c1
Show InChI InChI=1S/C19H15ClN8O/c1-10(26-19-14(7-21)18(22)24-9-25-19)13-6-16-23-8-15(20)28(16)27-17(13)11-3-2-4-12(29)5-11/h2-6,8-10,29H,1H3,(H3,22,24,25,26)/t10-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350412
PNG
((S)-4-amino-6-((1-(3-chloro-6-(3,5-difluorophenyl)...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-14(6-23)18(24)26-8-27-19)13-5-16-25-7-15(20)30(16)29-17(13)10-2-11(21)4-12(22)3-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350426
PNG
(US10208066, Compound 45 | US10611777, Compound 45)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N8/c1-10(30-19-13(7-25)18(26)28-9-29-19)12-6-16-27-8-15(21)32(16)31-17(12)11-4-2-3-5-14(11)20(22,23)24/h2-6,8-10H,1H3,(H3,26,28,29,30)/t10-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436061
PNG
(US10611777, Compound 11)
Show SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350422
PNG
(US10208066, Compound 41 | US10611777, Compound 41)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(Cl)c1
Show InChI InChI=1S/C19H14Cl2N8/c1-10(27-19-14(7-22)18(23)25-9-26-19)13-6-16-24-8-15(21)29(16)28-17(13)11-3-2-4-12(20)5-11/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350397
PNG
(US10208066, Compound 13 | US10611777, Compound 13)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F
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n/an/a 3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350399
PNG
(US10208066, Compound 16 | US10611777, Compound 16)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
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n/an/a 3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350417
PNG
(US10208066, Compound 36 | US10611777, Compound 36)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1F
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-12(6-23)18(24)26-8-27-19)11-5-15-25-7-14(20)30(15)29-17(11)10-3-2-4-13(21)16(10)22/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350411
PNG
(US10208066, Compound 29 | US10611777, Compound 29)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccn1
Show InChI InChI=1S/C19H16ClN9/c1-2-13(27-19-12(8-21)18(22)25-10-26-19)11-7-16-24-9-15(20)29(16)28-17(11)14-5-3-4-6-23-14/h3-7,9-10,13H,2H2,1H3,(H3,22,25,26,27)
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n/an/a 3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436084
PNG
((S)-4-amino-6-((1-(3-chloro-6-(o-tolyl)imidazo[1,2...)
Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)c2cc([C@H](C)NS(=O)C(C)(C)C)c(nn2)-c2ccccc2C)cc1
Show InChI InChI=1S/C33H40N4O3S/c1-23-10-8-9-11-29(23)32-30(24(2)36-41(38)33(3,4)5)20-31(34-35-32)37(21-25-12-16-27(39-6)17-13-25)22-26-14-18-28(40-7)19-15-26/h8-20,24,36H,21-22H2,1-7H3/t24-,41?/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350427
PNG
(US10208066, Compound 46 | US10611777, Compound 46)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C20H17ClN8O2S/c1-11(27-20-15(8-22)19(23)25-10-26-20)14-7-17-24-9-16(21)29(17)28-18(14)12-4-3-5-13(6-12)32(2,30)31/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436078
PNG
(US10611777, Compound 25)
Show SMILES CC[C@@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F
PDB
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350416
PNG
(US10208066, Compound 35 | US10611777, Compound 35)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)ccc1F
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-13(6-23)18(24)26-8-27-19)11-5-16-25-7-15(20)30(16)29-17(11)12-4-10(21)2-3-14(12)22/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350401
PNG
(US10208066, Compound 18 | US10611777, Compound 18)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1
PDB
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350450
PNG
(US10208066, Compound 72 | US10611777, Compound 72)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cnn(C)c1
Show InChI InChI=1S/C17H15ClN10/c1-9(25-17-12(4-19)16(20)22-8-23-17)11-3-14-21-6-13(18)28(14)26-15(11)10-5-24-27(2)7-10/h3,5-9H,1-2H3,(H3,20,22,23,25)/t9-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350437
PNG
(US10208066, Compound 59 | US10611777, Compound 59)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2nc(C)c(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H17ClN8/c1-11(27-20-15(9-22)19(23)24-10-25-20)14-8-16-26-12(2)18(21)29(16)28-17(14)13-6-4-3-5-7-13/h3-8,10-11H,1-2H3,(H3,23,24,25,27)/t11-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350445
PNG
(US10208066, Compound 67 | US10611777, Compound 67)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(C)cc(F)c1
Show InChI InChI=1S/C20H16ClFN8/c1-10-3-12(5-13(22)4-10)18-14(6-17-25-8-16(21)30(17)29-18)11(2)28-20-15(7-23)19(24)26-9-27-20/h3-6,8-9,11H,1-2H3,(H3,24,26,27,28)/t11-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436076
PNG
(US10611777, Compound 23)
Show SMILES C[C@H](Nc1ncnc2[nH]ccc12)c1cc2ncc(C)n2nc1-c1ccccc1
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n/an/a 6n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350441
PNG
(US10208066, Compound 63 | US10611777, Compound 63)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-12(6-23)18(24)26-8-27-19)11-5-16-25-7-15(20)30(16)29-17(11)10-2-3-13(21)14(22)4-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436074
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES CC(Nc1ncnc(N)c1-c1nn[nH]n1)c1cc2ncc(Cl)n2nc1-c1ccccc1
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n/an/a 6n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350439
PNG
(US10208066, Compound 61 | US10611777, Compound 61)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc2cccnc2c1
Show InChI InChI=1S/C22H16ClN9/c1-12(30-22-16(9-24)21(25)28-11-29-22)15-8-19-27-10-18(23)32(19)31-20(15)14-5-4-13-3-2-6-26-17(13)7-14/h2-8,10-12H,1H3,(H3,25,28,29,30)/t12-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350434
PNG
(US10208066, Compound 54 | US10611777, Compound 54)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(O)c1
Show InChI InChI=1S/C19H15ClN8O/c1-10(26-19-14(7-21)18(22)24-9-25-19)13-6-16-23-8-15(20)28(16)27-17(13)11-3-2-4-12(29)5-11/h2-6,8-10,29H,1H3,(H3,22,24,25,26)/t10-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350444
PNG
(US10208066, Compound 66 | US10611777, Compound 66)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H13Cl2FN8/c1-9(28-19-14(6-23)18(24)26-8-27-19)13-5-16-25-7-15(21)30(16)29-17(13)10-2-11(20)4-12(22)3-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350452
PNG
(US10208066, Compound 74 | US10611777, Compound 74)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc2scnc2c1
Show InChI InChI=1S/C20H14ClN9S/c1-10(28-20-13(6-22)19(23)25-8-26-20)12-5-17-24-7-16(21)30(17)29-18(12)11-2-3-15-14(4-11)27-9-31-15/h2-5,7-10H,1H3,(H3,23,25,26,28)/t10-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350429
PNG
(US10208066, Compound 48 | US10611777, Compound 48)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N8/c1-10(30-19-14(7-25)18(26)28-9-29-19)13-6-16-27-8-15(21)32(16)31-17(13)11-3-2-4-12(5-11)20(22,23)24/h2-6,8-10H,1H3,(H3,26,28,29,30)/t10-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350393
PNG
((S)-4-amino-6-((1-(3-chloro-6-(pyridin-2-yl)imidaz...)
Show SMILES C[C@@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccn1
Show InChI InChI=1S/C18H14ClN9/c1-10(26-18-12(7-20)17(21)24-9-25-18)11-6-15-23-8-14(19)28(15)27-16(11)13-4-2-3-5-22-13/h2-6,8-10H,1H3,(H3,21,24,25,26)/t10-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350432
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C(O)=O)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H16ClN7O2/c1-10(25-18-15(19(28)29)17(21)23-9-24-18)12-7-14-22-8-13(20)27(14)26-16(12)11-5-3-2-4-6-11/h2-10H,1H3,(H,28,29)(H3,21,23,24,25)/t10-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436132
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2nccn2nc1-c1ccccc1
Show InChI InChI=1S/C21H19N9O/c1-12(26-20-17(19(22)24-11-25-20)21-27-13(2)29-31-21)15-10-16-23-8-9-30(16)28-18(15)14-6-4-3-5-7-14/h3-12H,1-2H3,(H3,22,24,25,26)/t12-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350414
PNG
(US10208066, Compound 32 | US10611777, Compound 32)
Show SMILES C[C@H](Nc1nc(C)nc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H17ClN8/c1-11(25-20-15(9-22)19(23)26-12(2)27-20)14-8-17-24-10-16(21)29(17)28-18(14)13-6-4-3-5-7-13/h3-8,10-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350428
PNG
(US10208066, Compound 47 | US10611777, Compound 47)
Show SMILES CC[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
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n/an/a 18n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350448
PNG
(US10208066, Compound 70 | US10611777, Compound 70)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc2OCCOc2c1
Show InChI InChI=1S/C21H17ClN8O2/c1-11(28-21-14(8-23)20(24)26-10-27-21)13-7-18-25-9-17(22)30(18)29-19(13)12-2-3-15-16(6-12)32-5-4-31-15/h2-3,6-7,9-11H,4-5H2,1H3,(H3,24,26,27,28)/t11-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350447
PNG
((S)-4-amino-6-((1-(3-chloro-6-(2-hydroxyphenyl)imi...)
Show SMILES COc1ccccc1-c1nn2c(Cl)cnc2cc1[C@H](C)Nc1ncnc(N)c1C#N
Show InChI InChI=1S/C20H17ClN8O/c1-11(27-20-14(8-22)19(23)25-10-26-20)13-7-17-24-9-16(21)29(17)28-18(13)12-5-3-4-6-15(12)30-2/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436080
PNG
((S)-7-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin...)
Show SMILES C[C@H](Nc1ncnc(Cl)c1CCO)c1cc2nccn2nc1-c1ccccc1
Show InChI InChI=1S/C20H19ClN6O/c1-13(25-20-15(7-10-28)19(21)23-12-24-20)16-11-17-22-8-9-27(17)26-18(16)14-5-3-2-4-6-14/h2-6,8-9,11-13,28H,7,10H2,1H3,(H,23,24,25)/t13-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350400
PNG
(US10208066, Compound 17 | US10611777, Compound 17)
Show SMILES C[C@H](Nc1ncnc2[nH]ccc12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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n/an/a 26n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350388
PNG
(4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin-7-y...)
Show SMILES CC(Nc1ncnc(N)c1C#N)c1cc2nccn2nc1-c1ccccc1
Show InChI InChI=1S/C19H16N8/c1-12(25-19-15(10-20)18(21)23-11-24-19)14-9-16-22-7-8-27(16)26-17(14)13-5-3-2-4-6-13/h2-9,11-12H,1H3,(H3,21,23,24,25)
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n/an/a 28n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350438
PNG
(US10208066, Compound 60 | US10611777, Compound 60)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccsc1
Show InChI InChI=1S/C17H13ClN8S/c1-9(24-17-12(5-19)16(20)22-8-23-17)11-4-14-21-6-13(18)26(14)25-15(11)10-2-3-27-7-10/h2-4,6-9H,1H3,(H3,20,22,23,24)/t9-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350391
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM436060
PNG
(US10611777, Compound 9)
Show SMILES C[C@@H](Nc1ncnc2[nH]cc(C#N)c12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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n/an/a 46n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350438
PNG
(US10208066, Compound 60 | US10611777, Compound 60)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccsc1
Show InChI InChI=1S/C17H13ClN8S/c1-9(24-17-12(5-19)16(20)22-8-23-17)11-4-14-21-6-13(18)26(14)25-15(11)10-2-3-27-7-10/h2-4,6-9H,1H3,(H3,20,22,23,24)/t9-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350390
PNG
((R)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350442
PNG
(US10208066, Compound 64 | US10611777, Compound 64)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C19H13Cl2FN8/c1-9(28-19-12(6-23)18(24)26-8-27-19)11-5-16-25-7-15(21)30(16)29-17(11)10-2-3-13(20)14(22)4-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350427
PNG
(US10208066, Compound 46 | US10611777, Compound 46)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C20H17ClN8O2S/c1-11(27-20-15(8-22)19(23)25-10-26-20)14-7-17-24-9-16(21)29(17)28-18(14)12-4-3-5-13(6-12)32(2,30)31/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350391
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 59n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350435
PNG
(US10208066, Compound 57 | US10611777, Compound 57)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1cnn(C)c1)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C22H20ClN9/c1-13(29-22-19(21(24)26-12-27-22)15-9-28-31(2)11-15)16-8-18-25-10-17(23)32(18)30-20(16)14-6-4-3-5-7-14/h3-13H,1-2H3,(H3,24,26,27,29)/t13-/m0/s1
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n/an/a 62n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350419
PNG
(US10208066, Compound 38 | US10611777, Compound 38)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1ccc(O)c(F)c1)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C24H19ClFN7O/c1-13(31-24-21(23(27)29-12-30-24)15-7-8-18(34)17(26)9-15)16-10-20-28-11-19(25)33(20)32-22(16)14-5-3-2-4-6-14/h2-13,34H,1H3,(H3,27,29,30,31)/t13-/m0/s1
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n/an/a 66n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350403
PNG
((s)-9-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin...)
Show SMILES C[C@@H](c1cc2ncc(Cl)n2nc1-c1ccccc1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C19H15ClN8/c1-11(27-10-25-17-18(21)23-9-24-19(17)27)13-7-15-22-8-14(20)28(15)26-16(13)12-5-3-2-4-6-12/h2-11H,1H3,(H2,21,23,24)/t11-/m0/s1
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n/an/a 73n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350420
PNG
(US10208066, Compound 39 | US10611777, Compound 39)
Show SMILES COc1ccc(cn1)-c1c(N)ncnc1N[C@@H](C)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C24H21ClN8O/c1-14(31-24-21(23(26)29-13-30-24)16-8-9-20(34-2)28-11-16)17-10-19-27-12-18(25)33(19)32-22(17)15-6-4-3-5-7-15/h3-14H,1-2H3,(H3,26,29,30,31)/t14-/m0/s1
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n/an/a 73n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350432
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C(O)=O)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H16ClN7O2/c1-10(25-18-15(19(28)29)17(21)23-9-24-18)12-7-14-22-8-13(20)27(14)26-16(12)11-5-3-2-4-6-11/h2-10H,1H3,(H,28,29)(H3,21,23,24,25)/t10-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350396
PNG
(US10208066, Compound 12 | US10611777, Compound 12)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F
Show InChI InChI=1S/C19H14ClFN8/c1-10(27-19-13(7-22)18(23)25-9-26-19)12-6-16-24-8-15(20)29(16)28-17(12)11-4-2-3-5-14(11)21/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350451
PNG
(US10208066, Compound 73 | US10611777, Compound 73)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccncc1
Show InChI InChI=1S/C18H14ClN9/c1-10(26-18-13(7-20)17(21)24-9-25-18)12-6-15-23-8-14(19)28(15)27-16(12)11-2-4-22-5-3-11/h2-6,8-10H,1H3,(H3,21,24,25,26)/t10-/m0/s1
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n/an/a 82n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350391
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 87n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350450
PNG
(US10208066, Compound 72 | US10611777, Compound 72)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cnn(C)c1
Show InChI InChI=1S/C17H15ClN10/c1-9(25-17-12(4-19)16(20)22-8-23-17)11-3-14-21-6-13(18)28(14)26-15(11)10-5-24-27(2)7-10/h3,5-9H,1-2H3,(H3,20,22,23,25)/t9-/m0/s1
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n/an/a 89n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM436061
PNG
(US10611777, Compound 11)
Show SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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n/an/a 94n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM436131
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES C[C@H](Nc1ncnc(N)c1C(=O)NNC(C)=O)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C21H20ClN9O2/c1-11(27-20-17(19(23)25-10-26-20)21(33)29-28-12(2)32)14-8-16-24-9-15(22)31(16)30-18(14)13-6-4-3-5-7-13/h3-11H,1-2H3,(H,28,32)(H,29,33)(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 98n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350441
PNG
(US10208066, Compound 63 | US10611777, Compound 63)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-12(6-23)18(24)26-8-27-19)11-5-16-25-7-15(20)30(16)29-17(11)10-2-3-13(21)14(22)4-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 105n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350449
PNG
(US10208066, Compound 71 | US10611777, Compound 71)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H17ClN8/c1-13(30-23-18(10-25)22(26)28-12-29-23)17-9-20-27-11-19(24)32(20)31-21(17)16-7-6-14-4-2-3-5-15(14)8-16/h2-9,11-13H,1H3,(H3,26,28,29,30)/t13-/m0/s1
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n/an/a 129n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436095
PNG
((R)-4-amino-6-((1-(3-chloro-6-(3-fluorophenyl)imid...)
Show SMILES CC[C@@H](N[S@](=O)C(C)(C)C)c1cc(NCc2ccc(OC)cc2)nnc1-c1cccc(F)c1
Show InChI InChI=1S/C25H31FN4O2S/c1-6-22(30-33(31)25(2,3)4)21-15-23(27-16-17-10-12-20(32-5)13-11-17)28-29-24(21)18-8-7-9-19(26)14-18/h7-15,22,30H,6,16H2,1-5H3,(H,27,28)/t22-,33-/m1/s1
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n/an/a 132n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350447
PNG
((S)-4-amino-6-((1-(3-chloro-6-(2-hydroxyphenyl)imi...)
Show SMILES COc1ccccc1-c1nn2c(Cl)cnc2cc1[C@H](C)Nc1ncnc(N)c1C#N
Show InChI InChI=1S/C20H17ClN8O/c1-11(27-20-14(8-22)19(23)25-10-26-20)13-7-17-24-9-16(21)29(17)28-18(13)12-5-3-4-6-15(12)30-2/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 133n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350436
PNG
(US10208066, Compound 58 | US10611777, Compound 58)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2nc(C)cn2nc1-c1ccccc1
Show InChI InChI=1S/C20H18N8/c1-12-10-28-17(25-12)8-15(18(27-28)14-6-4-3-5-7-14)13(2)26-20-16(9-21)19(22)23-11-24-20/h3-8,10-11,13H,1-2H3,(H3,22,23,24,26)/t13-/m0/s1
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n/an/a 138n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM436084
PNG
((S)-4-amino-6-((1-(3-chloro-6-(o-tolyl)imidazo[1,2...)
Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)c2cc([C@H](C)NS(=O)C(C)(C)C)c(nn2)-c2ccccc2C)cc1
Show InChI InChI=1S/C33H40N4O3S/c1-23-10-8-9-11-29(23)32-30(24(2)36-41(38)33(3,4)5)20-31(34-35-32)37(21-25-12-16-27(39-6)17-13-25)22-26-14-18-28(40-7)19-15-26/h8-20,24,36H,21-22H2,1-7H3/t24-,41?/m0/s1
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n/an/a 146n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350430
PNG
(US10208066, Compound 49 | US10611777, Compound 49)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(O)cc1
Show InChI InChI=1S/C19H15ClN8O/c1-10(26-19-14(7-21)18(22)24-9-25-19)13-6-16-23-8-15(20)28(16)27-17(13)11-2-4-12(29)5-3-11/h2-6,8-10,29H,1H3,(H3,22,24,25,26)/t10-/m0/s1
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n/an/a 146n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM436060
PNG
(US10611777, Compound 9)
Show SMILES C[C@@H](Nc1ncnc2[nH]cc(C#N)c12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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n/an/a 158n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350389
PNG
(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Show SMILES CC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)
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n/an/a 168n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350411
PNG
(US10208066, Compound 29 | US10611777, Compound 29)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccn1
Show InChI InChI=1S/C19H16ClN9/c1-2-13(27-19-12(8-21)18(22)25-10-26-19)11-7-16-24-9-15(20)29(16)28-17(11)14-5-3-4-6-23-14/h3-7,9-10,13H,2H2,1H3,(H3,22,25,26,27)
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n/an/a 174n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350426
PNG
(US10208066, Compound 45 | US10611777, Compound 45)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N8/c1-10(30-19-13(7-25)18(26)28-9-29-19)12-6-16-27-8-15(21)32(16)31-17(12)11-4-2-3-5-14(11)20(22,23)24/h2-6,8-10H,1H3,(H3,26,28,29,30)/t10-/m0/s1
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n/an/a 195n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM436132
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2nccn2nc1-c1ccccc1
Show InChI InChI=1S/C21H19N9O/c1-12(26-20-17(19(22)24-11-25-20)21-27-13(2)29-31-21)15-10-16-23-8-9-30(16)28-18(15)14-6-4-3-5-7-14/h3-12H,1-2H3,(H3,22,24,25,26)/t12-/m0/s1
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n/an/a 203n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350434
PNG
(US10208066, Compound 54 | US10611777, Compound 54)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(O)c1
Show InChI InChI=1S/C19H15ClN8O/c1-10(26-19-14(7-21)18(22)24-9-25-19)13-6-16-23-8-15(20)28(16)27-17(13)11-3-2-4-12(29)5-11/h2-6,8-10,29H,1H3,(H3,22,24,25,26)/t10-/m0/s1
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n/an/a 226n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350453
PNG
(US10208066, Compound 77 | US10611777, Compound 77)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccnc1
Show InChI InChI=1S/C18H14ClN9/c1-10(26-18-13(6-20)17(21)24-9-25-18)12-5-15-23-8-14(19)28(15)27-16(12)11-3-2-4-22-7-11/h2-5,7-10H,1H3,(H3,21,24,25,26)/t10-/m0/s1
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n/an/a 238n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350414
PNG
(US10208066, Compound 32 | US10611777, Compound 32)
Show SMILES C[C@H](Nc1nc(C)nc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H17ClN8/c1-11(25-20-15(9-22)19(23)26-12(2)27-20)14-8-17-24-10-16(21)29(17)28-18(14)13-6-4-3-5-7-13/h3-8,10-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 243n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350417
PNG
(US10208066, Compound 36 | US10611777, Compound 36)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1F
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-12(6-23)18(24)26-8-27-19)11-5-15-25-7-14(20)30(15)29-17(11)10-3-2-4-13(21)16(10)22/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 243n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350440
PNG
(US10208066, Compound 62 | US10611777, Compound 62)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(C)c1
Show InChI InChI=1S/C20H17ClN8/c1-11-4-3-5-13(6-11)18-14(7-17-24-9-16(21)29(17)28-18)12(2)27-20-15(8-22)19(23)25-10-26-20/h3-7,9-10,12H,1-2H3,(H3,23,25,26,27)/t12-/m0/s1
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n/an/a 247n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350391
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 272n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350421
PNG
(US10208066, Compound 40 | US10611777, Compound 40)
Show SMILES C[C@H](Nc1ncnc(N)c1Cl)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C18H15Cl2N7/c1-10(25-18-15(20)17(21)23-9-24-18)12-7-14-22-8-13(19)27(14)26-16(12)11-5-3-2-4-6-11/h2-10H,1H3,(H3,21,23,24,25)/t10-/m0/s1
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n/an/a 277n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350425
PNG
(US10208066, Compound 44 | US10611777, Compound 44)
Show SMILES CC[C@@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
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n/an/a 283n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436086
PNG
((S)-4-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES CNc1ncnc(N[C@H](C)c2cc3ncc(Cl)n3nc2-c2ccccc2)c1C#N
Show InChI InChI=1S/C20H17ClN8/c1-12(27-20-15(9-22)19(23-2)25-11-26-20)14-8-17-24-10-16(21)29(17)28-18(14)13-6-4-3-5-7-13/h3-8,10-12H,1-2H3,(H2,23,25,26,27)/t12-/m1/s1
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n/an/a 288n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM350418
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1cccc(F)c1)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C24H19ClFN7/c1-14(31-24-21(23(27)29-13-30-24)16-8-5-9-17(26)10-16)18-11-20-28-12-19(25)33(20)32-22(18)15-6-3-2-4-7-15/h2-14H,1H3,(H3,27,29,30,31)/t14-/m0/s1
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n/an/a 288n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350392
PNG
((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...)
Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1
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n/an/a 303n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350405
PNG
(US10208066, Compound 22 | US10611777, Compound 22)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(C)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H18N8/c1-12-10-23-17-8-15(18(27-28(12)17)14-6-4-3-5-7-14)13(2)26-20-16(9-21)19(22)24-11-25-20/h3-8,10-11,13H,1-2H3,(H3,22,24,25,26)/t13-/m0/s1
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n/an/a 322n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350389
PNG
(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Show SMILES CC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)
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n/an/a 323n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350399
PNG
(US10208066, Compound 16 | US10611777, Compound 16)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
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n/an/a 326n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350442
PNG
(US10208066, Compound 64 | US10611777, Compound 64)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C19H13Cl2FN8/c1-9(28-19-12(6-23)18(24)26-8-27-19)11-5-16-25-7-15(21)30(16)29-17(11)10-2-3-13(20)14(22)4-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a>333n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350421
PNG
(US10208066, Compound 40 | US10611777, Compound 40)
Show SMILES C[C@H](Nc1ncnc(N)c1Cl)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C18H15Cl2N7/c1-10(25-18-15(20)17(21)23-9-24-18)12-7-14-22-8-13(19)27(14)26-16(12)11-5-3-2-4-6-11/h2-10H,1H3,(H3,21,23,24,25)/t10-/m0/s1
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n/an/a>333n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436094
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@@H](N(C)c1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(Cl)c1
Show InChI InChI=1S/C20H16Cl2N8/c1-11(29(2)20-15(8-23)19(24)26-10-27-20)14-7-17-25-9-16(22)30(17)28-18(14)12-4-3-5-13(21)6-12/h3-7,9-11H,1-2H3,(H2,24,26,27)/t11-/m1/s1
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n/an/a 339n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM436076
PNG
(US10611777, Compound 23)
Show SMILES C[C@H](Nc1ncnc2[nH]ccc12)c1cc2ncc(C)n2nc1-c1ccccc1
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n/an/a 343n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350446
PNG
(US10208066, Compound 68 | US10611777, Compound 68)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1S(C)(=O)=O
Show InChI InChI=1S/C20H17ClN8O2S/c1-11(27-20-14(8-22)19(23)25-10-26-20)13-7-17-24-9-16(21)29(17)28-18(13)12-5-3-4-6-15(12)32(2,30)31/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 345n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM436084
PNG
((S)-4-amino-6-((1-(3-chloro-6-(o-tolyl)imidazo[1,2...)
Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)c2cc([C@H](C)NS(=O)C(C)(C)C)c(nn2)-c2ccccc2C)cc1
Show InChI InChI=1S/C33H40N4O3S/c1-23-10-8-9-11-29(23)32-30(24(2)36-41(38)33(3,4)5)20-31(34-35-32)37(21-25-12-16-27(39-6)17-13-25)22-26-14-18-28(40-7)19-15-26/h8-20,24,36H,21-22H2,1-7H3/t24-,41?/m0/s1
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n/an/a 371n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350398
PNG
(US10208066, Compound 15 | US10611777, Compound 15)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
Show InChI InChI=1S/C19H14ClFN8/c1-10(27-19-14(7-22)18(23)25-9-26-19)13-6-16-24-8-15(20)29(16)28-17(13)11-3-2-4-12(21)5-11/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a 393n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350412
PNG
((S)-4-amino-6-((1-(3-chloro-6-(3,5-difluorophenyl)...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-14(6-23)18(24)26-8-27-19)13-5-16-25-7-15(20)30(16)29-17(13)10-2-11(21)4-12(22)3-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 410n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM436074
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES CC(Nc1ncnc(N)c1-c1nn[nH]n1)c1cc2ncc(Cl)n2nc1-c1ccccc1
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n/an/a 424n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350453
PNG
(US10208066, Compound 77 | US10611777, Compound 77)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccnc1
Show InChI InChI=1S/C18H14ClN9/c1-10(26-18-13(6-20)17(21)24-9-25-18)12-5-15-23-8-14(19)28(15)27-16(12)11-3-2-4-22-7-11/h2-5,7-10H,1H3,(H3,21,24,25,26)/t10-/m0/s1
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n/an/a 436n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350426
PNG
(US10208066, Compound 45 | US10611777, Compound 45)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N8/c1-10(30-19-13(7-25)18(26)28-9-29-19)12-6-16-27-8-15(21)32(16)31-17(12)11-4-2-3-5-14(11)20(22,23)24/h2-6,8-10H,1H3,(H3,26,28,29,30)/t10-/m0/s1
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n/an/a 450n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350397
PNG
(US10208066, Compound 13 | US10611777, Compound 13)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F
PDB
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n/an/a 484n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350422
PNG
(US10208066, Compound 41 | US10611777, Compound 41)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(Cl)c1
Show InChI InChI=1S/C19H14Cl2N8/c1-10(27-19-14(7-22)18(23)25-9-26-19)13-6-16-24-8-15(21)29(16)28-17(13)11-3-2-4-12(20)5-11/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a 499n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM436074
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES CC(Nc1ncnc(N)c1-c1nn[nH]n1)c1cc2ncc(Cl)n2nc1-c1ccccc1
PDB
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n/an/a 500n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350450
PNG
(US10208066, Compound 72 | US10611777, Compound 72)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cnn(C)c1
Show InChI InChI=1S/C17H15ClN10/c1-9(25-17-12(4-19)16(20)22-8-23-17)11-3-14-21-6-13(18)28(14)26-15(11)10-5-24-27(2)7-10/h3,5-9H,1-2H3,(H3,20,22,23,25)/t9-/m0/s1
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n/an/a 513n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350396
PNG
(US10208066, Compound 12 | US10611777, Compound 12)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F
Show InChI InChI=1S/C19H14ClFN8/c1-10(27-19-13(7-22)18(23)25-9-26-19)12-6-16-24-8-15(20)29(16)28-17(12)11-4-2-3-5-14(11)21/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350443
PNG
(US10208066, Compound 65 | US10611777, Compound 65)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)C#N
Show InChI InChI=1S/C20H14ClN9/c1-11(28-20-15(8-23)19(24)26-10-27-20)14-6-17-25-9-16(21)30(17)29-18(14)13-4-2-3-12(5-13)7-22/h2-6,9-11H,1H3,(H3,24,26,27,28)/t11-/m0/s1
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n/an/a 611n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350401
PNG
(US10208066, Compound 18 | US10611777, Compound 18)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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n/an/a 617n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM436131
PNG
((S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazi...)
Show SMILES C[C@H](Nc1ncnc(N)c1C(=O)NNC(C)=O)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C21H20ClN9O2/c1-11(27-20-17(19(23)25-10-26-20)21(33)29-28-12(2)32)14-8-16-24-9-15(22)31(16)30-18(14)13-6-4-3-5-7-13/h3-11H,1-2H3,(H,28,32)(H,29,33)(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 630n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350454
PNG
((S)-4-amino-6-(0-(3-fluoro-6-phenylimidazo[1,2-b]p...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(F)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15FN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 712n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436079
PNG
(US10611777, Compound 26)
Show SMILES CC[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F
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n/an/a 839n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM436102
PNG
((S)-6-amino-4-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](NC1=C(C#N)C(N)=[N](O)C=N1)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H16ClN8O/c1-11(25-19-14(8-21)18(22)27(29)10-24-19)13-7-16-23-9-15(20)28(16)26-17(13)12-5-3-2-4-6-12/h2-7,9-11,29H,1H3,(H3,22,24,25)/t11-/m0/s1
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n/an/a 957n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350446
PNG
(US10208066, Compound 68 | US10611777, Compound 68)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1S(C)(=O)=O
Show InChI InChI=1S/C20H17ClN8O2S/c1-11(27-20-14(8-22)19(23)25-10-26-20)13-7-17-24-9-16(21)29(17)28-18(13)12-5-3-4-6-15(12)32(2,30)31/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 963n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350399
PNG
(US10208066, Compound 16 | US10611777, Compound 16)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350402
PNG
(US10208066, Compound 19 | US10611777, Compound 19)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F
Show InChI InChI=1S/C20H16ClFN8/c1-2-15(28-20-13(8-23)19(24)26-10-27-20)12-7-17-25-9-16(21)30(17)29-18(12)11-5-3-4-6-14(11)22/h3-7,9-10,15H,2H2,1H3,(H3,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350403
PNG
((s)-9-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin...)
Show SMILES C[C@@H](c1cc2ncc(Cl)n2nc1-c1ccccc1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C19H15ClN8/c1-11(27-10-25-17-18(21)23-9-24-19(17)27)13-7-15-22-8-14(20)28(15)26-16(13)12-5-3-2-4-6-12/h2-11H,1H3,(H2,21,23,24)/t11-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350400
PNG
(US10208066, Compound 17 | US10611777, Compound 17)
Show SMILES C[C@H](Nc1ncnc2[nH]ccc12)c1cc2ncc(Cl)n2nc1-c1ccccc1
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350393
PNG
((S)-4-amino-6-((1-(3-chloro-6-(pyridin-2-yl)imidaz...)
Show SMILES C[C@@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccn1
Show InChI InChI=1S/C18H14ClN9/c1-10(26-18-12(7-20)17(21)24-9-25-18)11-6-15-23-8-14(19)28(15)27-16(11)13-4-2-3-5-22-13/h2-6,8-10H,1H3,(H3,21,24,25,26)/t10-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350397
PNG
(US10208066, Compound 13 | US10611777, Compound 13)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350401
PNG
(US10208066, Compound 18 | US10611777, Compound 18)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1
PDB

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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350392
PNG
((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...)
Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350389
PNG
(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Show SMILES CC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350398
PNG
(US10208066, Compound 15 | US10611777, Compound 15)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1
Show InChI InChI=1S/C19H14ClFN8/c1-10(27-19-14(7-22)18(23)25-9-26-19)13-6-16-24-8-15(20)29(16)28-17(13)11-3-2-4-12(21)5-11/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM350391
PNG
((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350412
PNG
((S)-4-amino-6-((1-(3-chloro-6-(3,5-difluorophenyl)...)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-14(6-23)18(24)26-8-27-19)13-5-16-25-7-15(20)30(16)29-17(13)10-2-11(21)4-12(22)3-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350402
PNG
(US10208066, Compound 19 | US10611777, Compound 19)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F
Show InChI InChI=1S/C20H16ClFN8/c1-2-15(28-20-13(8-23)19(24)26-10-27-20)12-7-17-25-9-16(21)30(17)29-18(12)11-5-3-4-6-14(11)22/h3-7,9-10,15H,2H2,1H3,(H3,24,26,27,28)
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n/an/a 1.07E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350444
PNG
(US10208066, Compound 66 | US10611777, Compound 66)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H13Cl2FN8/c1-9(28-19-14(6-23)18(24)26-8-27-19)13-5-16-25-7-15(21)30(16)29-17(13)10-2-11(20)4-12(22)3-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350445
PNG
(US10208066, Compound 67 | US10611777, Compound 67)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(C)cc(F)c1
Show InChI InChI=1S/C20H16ClFN8/c1-10-3-12(5-13(22)4-10)18-14(6-17-25-8-16(21)30(17)29-18)11(2)28-20-15(7-23)19(24)26-9-27-20/h3-6,8-9,11H,1-2H3,(H3,24,26,27,28)/t11-/m0/s1
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n/an/a 1.15E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350437
PNG
(US10208066, Compound 59 | US10611777, Compound 59)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2nc(C)c(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H17ClN8/c1-11(27-20-15(9-22)19(23)24-10-25-20)14-8-16-26-12(2)18(21)29(16)28-17(14)13-6-4-3-5-7-13/h3-8,10-11H,1-2H3,(H3,23,24,25,27)/t11-/m0/s1
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n/an/a 1.16E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350440
PNG
(US10208066, Compound 62 | US10611777, Compound 62)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(C)c1
Show InChI InChI=1S/C20H17ClN8/c1-11-4-3-5-13(6-11)18-14(7-17-24-9-16(21)29(17)28-18)12(2)27-20-15(8-22)19(23)25-10-26-20/h3-7,9-10,12H,1-2H3,(H3,23,25,26,27)/t12-/m0/s1
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n/an/a 1.23E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350443
PNG
(US10208066, Compound 65 | US10611777, Compound 65)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)C#N
Show InChI InChI=1S/C20H14ClN9/c1-11(28-20-15(8-23)19(24)26-10-27-20)14-6-17-25-9-16(21)30(17)29-18(14)13-4-2-3-12(5-13)7-22/h2-6,9-11H,1H3,(H3,24,26,27,28)/t11-/m0/s1
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n/an/a 1.26E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350417
PNG
(US10208066, Compound 36 | US10611777, Compound 36)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(F)c1F
Show InChI InChI=1S/C19H13ClF2N8/c1-9(28-19-12(6-23)18(24)26-8-27-19)11-5-15-25-7-14(20)30(15)29-17(11)10-3-2-4-13(21)16(10)22/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 1.31E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350427
PNG
(US10208066, Compound 46 | US10611777, Compound 46)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C20H17ClN8O2S/c1-11(27-20-15(8-22)19(23)25-10-26-20)14-7-17-24-9-16(21)29(17)28-18(14)12-4-3-5-13(6-12)32(2,30)31/h3-7,9-11H,1-2H3,(H3,23,25,26,27)/t11-/m0/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350429
PNG
(US10208066, Compound 48 | US10611777, Compound 48)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N8/c1-10(30-19-14(7-25)18(26)28-9-29-19)13-6-16-27-8-15(21)32(16)31-17(13)11-3-2-4-12(5-11)20(22,23)24/h2-6,8-10H,1H3,(H3,26,28,29,30)/t10-/m0/s1
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n/an/a 1.33E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350422
PNG
(US10208066, Compound 41 | US10611777, Compound 41)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(Cl)c1
Show InChI InChI=1S/C19H14Cl2N8/c1-10(27-19-14(7-22)18(23)25-9-26-19)13-6-16-24-8-15(21)29(16)28-17(13)11-3-2-4-12(20)5-11/h2-6,8-10H,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a 1.33E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350397
PNG
(US10208066, Compound 13 | US10611777, Compound 13)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F
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n/an/a 1.92E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350402
PNG
(US10208066, Compound 19 | US10611777, Compound 19)
Show SMILES CCC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1F
Show InChI InChI=1S/C20H16ClFN8/c1-2-15(28-20-13(8-23)19(24)26-10-27-20)12-7-17-25-9-16(21)30(17)29-18(12)11-5-3-4-6-14(11)22/h3-7,9-10,15H,2H2,1H3,(H3,24,26,27,28)
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n/an/a 1.97E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350448
PNG
(US10208066, Compound 70 | US10611777, Compound 70)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccc2OCCOc2c1
Show InChI InChI=1S/C21H17ClN8O2/c1-11(28-21-14(8-23)20(24)26-10-27-21)13-7-18-25-9-17(22)30(18)29-19(13)12-2-3-15-16(6-12)32-5-4-31-15/h2-3,6-7,9-11H,4-5H2,1H3,(H3,24,26,27,28)/t11-/m0/s1
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n/an/a 1.98E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM350437
PNG
(US10208066, Compound 59 | US10611777, Compound 59)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2nc(C)c(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C20H17ClN8/c1-11(27-20-15(9-22)19(23)24-10-25-20)14-8-16-26-12(2)18(21)29(16)28-17(14)13-6-4-3-5-7-13/h3-8,10-11H,1-2H3,(H3,23,24,25,27)/t11-/m0/s1
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n/an/a 2.39E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
PIK3CG/PIK3R1


(Homo sapiens (Human))
BDBM436078
PNG
(US10611777, Compound 25)
Show SMILES CC[C@@H](Nc1ncnc2[nH]cnc12)c1cc2ncc(Cl)n2nc1-c1ccccc1F
PDB
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n/an/a 2.59E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350445
PNG
(US10208066, Compound 67 | US10611777, Compound 67)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(C)cc(F)c1
Show InChI InChI=1S/C20H16ClFN8/c1-10-3-12(5-13(22)4-10)18-14(6-17-25-8-16(21)30(17)29-18)11(2)28-20-15(7-23)19(24)26-9-27-20/h3-6,8-9,11H,1-2H3,(H3,24,26,27,28)/t11-/m0/s1
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n/an/a 3.58E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350429
PNG
(US10208066, Compound 48 | US10611777, Compound 48)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N8/c1-10(30-19-14(7-25)18(26)28-9-29-19)13-6-16-27-8-15(21)32(16)31-17(13)11-3-2-4-12(5-11)20(22,23)24/h2-6,8-10H,1H3,(H3,26,28,29,30)/t10-/m0/s1
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n/an/a 4.08E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350444
PNG
(US10208066, Compound 66 | US10611777, Compound 66)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C19H13Cl2FN8/c1-9(28-19-14(6-23)18(24)26-8-27-19)13-5-16-25-7-15(21)30(16)29-17(13)10-2-11(20)4-12(22)3-10/h2-5,7-9H,1H3,(H3,24,26,27,28)/t9-/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM350390
PNG
((R)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...)
Show SMILES C[C@@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
Show InChI InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m1/s1
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n/an/a 4.81E+3n/an/an/an/an/an/a



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...


US Patent US10611777 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%