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Patent code US10617676

Compile Data Set for Download or QSAR

Found 596 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436977
PNG
(1-[(4-Methyl-3-pyridyl)methyl]-6-(3,4,5-trifluorop...)
Show SMILES Cc1ccncc1Cn1c2cc(cnc2[nH]c1=O)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C19H13F3N4O/c1-10-2-3-23-7-13(10)9-26-16-6-12(8-24-18(16)25-19(26)27)11-4-14(20)17(22)15(21)5-11/h2-8H,9H2,1H3,(H,24,25,27)
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n/an/a 2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436994
PNG
(6-(3,4-Difluorophenyl)-1-(2-oxobutyl)-3H-imidazo[4...)
Show SMILES CCC(=O)Cn1c2cc(cnc2[nH]c1=O)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C16H13F2N3O2/c1-2-11(22)8-21-14-6-10(7-19-15(14)20-16(21)23)9-3-4-12(17)13(18)5-9/h3-7H,2,8H2,1H3,(H,19,20,23)
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n/an/a 4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436678
PNG
(2-[6-(5-Chloro-2-thienyl)-3-methyl-2-oxo-imidazo[4...)
Show SMILES CN(C)C(=O)Cn1c2cc(cnc2n(C)c1=O)-c1ccc(Cl)s1
Show InChI InChI=1S/C15H15ClN4O2S/c1-18(2)13(21)8-20-10-6-9(11-4-5-12(16)23-11)7-17-14(10)19(3)15(20)22/h4-7H,8H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437086
PNG
(2-[6-(2,4-Difluoro-3-methyl-phenyl)-3-methyl-2-oxo...)
Show SMILES CN(C)C(=O)Cn1c2cc(cnc2n(C)c1=O)-c1ccc(F)c(C)c1F
Show InChI InChI=1S/C18H18F2N4O2/c1-10-13(19)6-5-12(16(10)20)11-7-14-17(21-8-11)23(4)18(26)24(14)9-15(25)22(2)3/h5-8H,9H2,1-4H3
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n/an/a 6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436762
PNG
(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-[5-(difluorome...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1ccc(s1)C(F)F
Show InChI InChI=1S/C17H16F2N4O2S/c1-21-16-11(23(17(21)25)9-14(24)22-5-2-6-22)7-10(8-20-16)12-3-4-13(26-12)15(18)19/h3-4,7-8,15H,2,5-6,9H2,1H3
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n/an/a 6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436768
PNG
(6-[5-(Difluoromethyl)-3-thienyl]-1-[2-(3-fluoroaze...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)C2)c1=O)-c1csc(c1)C(F)F
Show InChI InChI=1S/C17H15F3N4O2S/c1-22-16-12(24(17(22)26)7-14(25)23-5-11(18)6-23)2-9(4-21-16)10-3-13(15(19)20)27-8-10/h2-4,8,11,15H,5-7H2,1H3
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n/an/a 7n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436860
PNG
(N-(3,3-Difluorocyclobutyl)-2-[2-oxo-6-[3-(trifluor...)
Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2[nH]c(=O)n(CC(=O)NC3CC(F)(F)C3)c2c1
Show InChI InChI=1S/C19H15F5N4O2/c20-18(21)6-13(7-18)26-15(29)9-28-14-5-11(8-25-16(14)27-17(28)30)10-2-1-3-12(4-10)19(22,23)24/h1-5,8,13H,6-7,9H2,(H,26,29)(H,25,27,30)
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n/an/a 7n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437073
PNG
(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-(2,4-difluoro-...)
Show SMILES Cc1c(F)ccc(-c2cnc3n(C)c(=O)n(CC(=O)N4CCC4)c3c2)c1F
Show InChI InChI=1S/C19H18F2N4O2/c1-11-14(20)5-4-13(17(11)21)12-8-15-18(22-9-12)23(2)19(27)25(15)10-16(26)24-6-3-7-24/h4-5,8-9H,3,6-7,10H2,1-2H3
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n/an/a 8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437111
PNG
(2-[6-(3-Chloro-4-fluoro-phenyl)-2-oxo-3H-imidazo[4...)
Show SMILES Fc1ccc(cc1Cl)-c1cnc2[nH]c(=O)n(CC(=O)NC3CC3)c2c1
Show InChI InChI=1S/C17H14ClFN4O2/c18-12-5-9(1-4-13(12)19)10-6-14-16(20-7-10)22-17(25)23(14)8-15(24)21-11-2-3-11/h1,4-7,11H,2-3,8H2,(H,21,24)(H,20,22,25)
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n/an/a 8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436719
PNG
(6-(4-Fluoro-3-methyl-phenyl)-3-methyl-1-(pyridazin...)
Show SMILES Cc1cc(ccc1F)-c1cnc2n(C)c(=O)n(Cc3cccnn3)c2c1
Show InChI InChI=1S/C19H16FN5O/c1-12-8-13(5-6-16(12)20)14-9-17-18(21-10-14)24(2)19(26)25(17)11-15-4-3-7-22-23-15/h3-10H,11H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436940
PNG
(6-(3,4-Difluorophenyl)-1-[(4-methyl-3-pyridyl)meth...)
Show SMILES Cc1ccncc1Cn1c2cc(cnc2[nH]c1=O)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H14F2N4O/c1-11-4-5-22-8-14(11)10-25-17-7-13(9-23-18(17)24-19(25)26)12-2-3-15(20)16(21)6-12/h2-9H,10H2,1H3,(H,23,24,26)
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n/an/a 9n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436736
PNG
(6-(2,4-Difluoro-3-methyl-phenyl)-3-methyl-1-(pyrid...)
Show SMILES Cc1c(F)ccc(c1F)-c1cnc2n(C)c(=O)n(Cc3cccnn3)c2c1
Show InChI InChI=1S/C19H15F2N5O/c1-11-15(20)6-5-14(17(11)21)12-8-16-18(22-9-12)25(2)19(27)26(16)10-13-4-3-7-23-24-13/h3-9H,10H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437076
PNG
(1-(2-(3,3-Difluoroazetidin-1-yl)-2-oxoethyl)-6-(4-...)
Show SMILES Cc1cc(ccc1F)-c1cnc2n(C)c(=O)n(CC(=O)N3CC(F)(F)C3)c2c1
Show InChI InChI=1S/C19H17F3N4O2/c1-11-5-12(3-4-14(11)20)13-6-15-17(23-7-13)24(2)18(28)26(15)8-16(27)25-9-19(21,22)10-25/h3-7H,8-10H2,1-2H3
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n/an/a 9n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437085
PNG
(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-(3,4-difluorop...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H16F2N4O2/c1-22-17-15(24(18(22)26)10-16(25)23-5-2-6-23)8-12(9-21-17)11-3-4-13(19)14(20)7-11/h3-4,7-9H,2,5-6,10H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436696
PNG
(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1ccc(s1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O2S/c1-22-15-11(24(16(22)26)9-14(25)23-5-2-6-23)7-10(8-21-15)12-3-4-13(27-12)17(18,19)20/h3-4,7-8H,2,5-6,9H2,1H3
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n/an/a 10n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436679
PNG
(6-[5-(Difluoromethyl)-2-thienyl]-1-[2-(3-fluoroaze...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)C2)c1=O)-c1ccc(s1)C(F)F
Show InChI InChI=1S/C17H15F3N4O2S/c1-22-16-11(24(17(22)26)8-14(25)23-6-10(18)7-23)4-9(5-21-16)12-2-3-13(27-12)15(19)20/h2-5,10,15H,6-8H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437079
PNG
(1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]-6-(3...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)(F)C2)c1=O)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H14F4N4O2/c1-24-16-14(5-11(6-23-16)10-2-3-12(19)13(20)4-10)26(17(24)28)7-15(27)25-8-18(21,22)9-25/h2-6H,7-9H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436699
PNG
(6-(2,4-Difluoro-3-methyl-phenyl)-1-(2-oxobutyl)-3H...)
Show SMILES CCC(=O)Cn1c2cc(cnc2[nH]c1=O)-c1ccc(F)c(C)c1F
Show InChI InChI=1S/C17H15F2N3O2/c1-3-11(23)8-22-14-6-10(7-20-16(14)21-17(22)24)12-4-5-13(18)9(2)15(12)19/h4-7H,3,8H2,1-2H3,(H,20,21,24)
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n/an/a 11n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436995
PNG
(6-(4-Fluoro-3-methyl-phenyl)-1-(2-oxobutyl)-3H-imi...)
Show SMILES CCC(=O)Cn1c2cc(cnc2[nH]c1=O)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C17H16FN3O2/c1-3-13(22)9-21-15-7-12(8-19-16(15)20-17(21)23)11-4-5-14(18)10(2)6-11/h4-8H,3,9H2,1-2H3,(H,19,20,23)
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n/an/a 12n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436695
PNG
(N,N-Dimethyl-2-[2-oxo-6-[5-(trifluoromethyl)-2-thi...)
Show SMILES CN(C)C(=O)Cn1c2cc(cnc2[nH]c1=O)-c1ccc(s1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N4O2S/c1-21(2)12(23)7-22-9-5-8(6-19-13(9)20-14(22)24)10-3-4-11(25-10)15(16,17)18/h3-6H,7H2,1-2H3,(H,19,20,24)
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n/an/a 12n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436767
PNG
(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-[5-(difluorome...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1csc(c1)C(F)F
Show InChI InChI=1S/C17H16F2N4O2S/c1-21-16-12(23(17(21)25)8-14(24)22-3-2-4-22)5-10(7-20-16)11-6-13(15(18)19)26-9-11/h5-7,9,15H,2-4,8H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437077
PNG
(1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]-6-(2...)
Show SMILES Cc1c(F)ccc(-c2cnc3n(C)c(=O)n(CC(=O)N4CC(F)(F)C4)c3c2)c1F
Show InChI InChI=1S/C19H16F4N4O2/c1-10-13(20)4-3-12(16(10)21)11-5-14-17(24-6-11)25(2)18(29)27(14)7-15(28)26-8-19(22,23)9-26/h3-6H,7-9H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436970
PNG
(6-(3-Chlorophenyl)-1-[(5-fluoro-3-pyridyl)methyl]-...)
Show SMILES Fc1cncc(Cn2c3cc(cnc3[nH]c2=O)-c2cccc(Cl)c2)c1
Show InChI InChI=1S/C18H12ClFN4O/c19-14-3-1-2-12(5-14)13-6-16-17(22-8-13)23-18(25)24(16)10-11-4-15(20)9-21-7-11/h1-9H,10H2,(H,22,23,25)
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n/an/a 13n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437232
PNG
(1-[2-(3-Fluoroazetidin-1-yl)-2-oxo-ethyl]-6-[5-(tr...)
Show SMILES FC1CN(C1)C(=O)Cn1c2cc(cnc2[nH]c1=O)-c1ccc(s1)C(F)(F)F
Show InChI InChI=1S/C16H12F4N4O2S/c17-9-5-23(6-9)13(25)7-24-10-3-8(4-21-14(10)22-15(24)26)11-1-2-12(27-11)16(18,19)20/h1-4,9H,5-7H2,(H,21,22,26)
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n/an/a 14n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436986
PNG
(2-[6-(5-Chloro-4-methyl-2-thienyl)-2-oxo-3H-imidaz...)
Show SMILES CN(C)C(=O)Cn1c2cc(cnc2[nH]c1=O)-c1cc(C)c(Cl)s1
Show InChI InChI=1S/C15H15ClN4O2S/c1-8-4-11(23-13(8)16)9-5-10-14(17-6-9)18-15(22)20(10)7-12(21)19(2)3/h4-6H,7H2,1-3H3,(H,17,18,22)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437074
PNG
(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-(3,4,...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C18H15F3N4O2/c1-23-17-14(25(18(23)27)9-15(26)24-3-2-4-24)7-11(8-22-17)10-5-12(19)16(21)13(20)6-10/h5-8H,2-4,9H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436989
PNG
(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-(5-chloro-4-me...)
Show SMILES Cc1cc(sc1Cl)-c1cnc2[nH]c(=O)n(CC(=O)N3CCC3)c2c1
Show InChI InChI=1S/C16H15ClN4O2S/c1-9-5-12(24-14(9)17)10-6-11-15(18-7-10)19-16(23)21(11)8-13(22)20-3-2-4-20/h5-7H,2-4,8H2,1H3,(H,18,19,23)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437078
PNG
(1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]-6-[2...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)(F)C2)c1=O)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C19H14F6N4O2/c1-27-16-13(29(17(27)31)7-14(30)28-8-18(21,22)9-28)5-10(6-26-16)11-3-2-4-12(15(11)20)19(23,24)25/h2-6H,7-9H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437233
PNG
(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-(2,4-difluoro-...)
Show SMILES Cc1c(F)ccc(-c2cnc3[nH]c(=O)n(CC(=O)N4CCC4)c3c2)c1F
Show InChI InChI=1S/C18H16F2N4O2/c1-10-13(19)4-3-12(16(10)20)11-7-14-17(21-8-11)22-18(26)24(14)9-15(25)23-5-2-6-23/h3-4,7-8H,2,5-6,9H2,1H3,(H,21,22,26)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436766
PNG
(2-[6-[5-(Difluoromethyl)-3-thienyl]-3-methyl-2-oxo...)
Show SMILES CN(C)C(=O)Cn1c2cc(cnc2n(C)c1=O)-c1csc(c1)C(F)F
Show InChI InChI=1S/C16H16F2N4O2S/c1-20(2)13(23)7-22-11-4-9(6-19-15(11)21(3)16(22)24)10-5-12(14(17)18)25-8-10/h4-6,8,14H,7H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437000
PNG
((R/S)-6-(2,4-difluoro-3-methyl-phenyl)-1-(2-hydrox...)
Show SMILES CCC(O)Cn1c2cc(cnc2[nH]c1=O)-c1ccc(F)c(C)c1F
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437044
PNG
(6-(3-Chloro-4-fluoro-phenyl)-3-methyl-1-(pyridazin...)
Show SMILES Cn1c2ncc(cc2n(Cc2cccnn2)c1=O)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C18H13ClFN5O/c1-24-17-16(25(18(24)26)10-13-3-2-6-22-23-13)8-12(9-21-17)11-4-5-15(20)14(19)7-11/h2-9H,10H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437066
PNG
(1-[2-(3-Fluoroazetidin-1-yl)-2-oxo-ethyl]-3-methyl...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)C2)c1=O)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C18H14F4N4O2/c1-24-17-14(26(18(24)28)8-15(27)25-6-11(19)7-25)4-10(5-23-17)9-2-12(20)16(22)13(21)3-9/h2-5,11H,6-8H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437196
PNG
(6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-methyl-1...)
Show SMILES Cn1c2ncc(cc2n(Cc2cccnn2)c1=O)-c1ccc(F)c(OC(F)F)c1
Show InChI InChI=1S/C19H14F3N5O2/c1-26-17-15(27(19(26)28)10-13-3-2-6-24-25-13)7-12(9-23-17)11-4-5-14(20)16(8-11)29-18(21)22/h2-9,18H,10H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437046
PNG
(6-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-methyl-1-...)
Show SMILES Cn1c2ncc(cc2n(Cc2cccnn2)c1=O)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C19H13F4N5O/c1-27-17-16(28(18(27)29)10-13-3-2-6-25-26-13)8-12(9-24-17)11-4-5-15(20)14(7-11)19(21,22)23/h2-9H,10H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437065
PNG
(1-[2-(3-Fluoroazetidin-1-yl)-2-oxo-ethyl]-6-(4-flu...)
Show SMILES Cc1cc(ccc1F)-c1cnc2n(C)c(=O)n(CC(=O)N3CC(F)C3)c2c1
Show InChI InChI=1S/C19H18F2N4O2/c1-11-5-12(3-4-15(11)21)13-6-16-18(22-7-13)23(2)19(27)25(16)10-17(26)24-8-14(20)9-24/h3-7,14H,8-10H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437070
PNG
(6-(3-Chlorophenyl)-1-[2-(3-fluoroazetidin-1-yl)-2-...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)C2)c1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H16ClFN4O2/c1-22-17-15(6-12(7-21-17)11-3-2-4-13(19)5-11)24(18(22)26)10-16(25)23-8-14(20)9-23/h2-7,14H,8-10H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436895
PNG
(1-(3-Pyridylmethyl)-6-[3-(trifluoromethyl)phenyl]-...)
Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2[nH]c(=O)n(Cc3cccnc3)c2c1
Show InChI InChI=1S/C19H13F3N4O/c20-19(21,22)15-5-1-4-13(7-15)14-8-16-17(24-10-14)25-18(27)26(16)11-12-3-2-6-23-9-12/h1-10H,11H2,(H,24,25,27)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437254
PNG
(6-(2,4-Difluoro-3-methyl-phenyl)-1-[2-(3-fluoroaze...)
Show SMILES Cc1c(F)ccc(-c2cnc3n(CF)c(=O)n(CC(=O)N4CC(F)C4)c3c2)c1F
Show InChI InChI=1S/C19H16F4N4O2/c1-10-14(22)3-2-13(17(10)23)11-4-15-18(24-5-11)27(9-20)19(29)26(15)8-16(28)25-6-12(21)7-25/h2-5,12H,6-9H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436897
PNG
(1-(Pyridazin-3-ylmethyl)-6-[3-(trifluoromethyl)phe...)
Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2[nH]c(=O)n(Cc3cccnn3)c2c1
Show InChI InChI=1S/C18H12F3N5O/c19-18(20,21)13-4-1-3-11(7-13)12-8-15-16(22-9-12)24-17(27)26(15)10-14-5-2-6-23-25-14/h1-9H,10H2,(H,22,24,27)
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437053
PNG
(6-(4-Fluoro-3-methyl-phenyl)-3-methyl-1-(2-oxobuty...)
Show SMILES CCC(=O)Cn1c2cc(cnc2n(C)c1=O)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C18H18FN3O2/c1-4-14(23)10-22-16-8-13(9-20-17(16)21(3)18(22)24)12-5-6-15(19)11(2)7-12/h5-9H,4,10H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436763
PNG
(2-[6-[5-(Difluoromethyl)-2-thienyl]-3-methyl-2-oxo...)
Show SMILES CN(C)C(=O)Cn1c2cc(cnc2n(C)c1=O)-c1ccc(s1)C(F)F
Show InChI InChI=1S/C16H16F2N4O2S/c1-20(2)13(23)8-22-10-6-9(7-19-15(10)21(3)16(22)24)11-4-5-12(25-11)14(17)18/h4-7,14H,8H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436771
PNG
(3-Methyl-1-(pyridazin-3-ylmethyl)-6-[5-(trifluorom...)
Show SMILES Cn1c2ncc(cc2n(Cc2cccnn2)c1=O)-c1csc(c1)C(F)(F)F
Show InChI InChI=1S/C17H12F3N5OS/c1-24-15-13(25(16(24)26)8-12-3-2-4-22-23-12)5-10(7-21-15)11-6-14(27-9-11)17(18,19)20/h2-7,9H,8H2,1H3
PDB
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n/an/a 17n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436958
PNG
(6-(2,4-Difluoro-3-methyl-phenyl)-1-(3-pyridylmethy...)
Show SMILES Cc1c(F)ccc(c1F)-c1cnc2[nH]c(=O)n(Cc3cccnc3)c2c1
Show InChI InChI=1S/C19H14F2N4O/c1-11-15(20)5-4-14(17(11)21)13-7-16-18(23-9-13)24-19(26)25(16)10-12-3-2-6-22-8-12/h2-9H,10H2,1H3,(H,23,24,26)
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n/an/a 17n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437064
PNG
(6-(2,4-Difluoro-3-methyl-phenyl)-1-[2-(3-fluoroaze...)
Show SMILES Cc1c(F)ccc(-c2cnc3n(C)c(=O)n(CC(=O)N4CC(F)C4)c3c2)c1F
Show InChI InChI=1S/C19H17F3N4O2/c1-10-14(21)4-3-13(17(10)22)11-5-15-18(23-6-11)24(2)19(28)26(15)9-16(27)25-7-12(20)8-25/h3-6,12H,7-9H2,1-2H3
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n/an/a 17n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437083
PNG
(2-[6-(4-Fuoro-3-methyl-phenyl)-3-methyl-2-oxo-imid...)
Show SMILES CN(C)C(=O)Cn1c2cc(cnc2n(C)c1=O)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C18H19FN4O2/c1-11-7-12(5-6-14(11)19)13-8-15-17(20-9-13)22(4)18(25)23(15)10-16(24)21(2)3/h5-9H,10H2,1-4H3
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n/an/a 17n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436978
PNG
(1-[(4-Methyl-3-pyridyl)methyl]-6-[3-(trifluorometh...)
Show SMILES Cc1ccncc1Cn1c2cc(cnc2[nH]c1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H15F3N4O/c1-12-5-6-24-9-15(12)11-27-17-8-14(10-25-18(17)26-19(27)28)13-3-2-4-16(7-13)20(21,22)23/h2-10H,11H2,1H3,(H,25,26,28)
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n/an/a 18n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM437239
PNG
(6-[3-(Difluoromethyl)-4-fluoro-phenyl]-1-[2-(3-flu...)
Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)C2)c1=O)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C19H16F4N4O2/c1-25-18-15(27(19(25)29)9-16(28)26-7-12(20)8-26)5-11(6-24-18)10-2-3-14(21)13(4-10)17(22)23/h2-6,12,17H,7-9H2,1H3
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n/an/a 18n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436770
PNG
(N,N-Dimethyl-2-[3-methyl-2-oxo-6-[5-(trifluorometh...)
Show SMILES CN(C)C(=O)Cn1c2cc(cnc2n(C)c1=O)-c1csc(c1)C(F)(F)F
Show InChI InChI=1S/C16H15F3N4O2S/c1-21(2)13(24)7-23-11-4-9(6-20-14(11)22(3)15(23)25)10-5-12(26-8-10)16(17,18)19/h4-6,8H,7H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM436964
PNG
(6-(4-Fluoro-3-methyl-phenyl)-1-[(5-fluoro-3-pyridy...)
Show SMILES Cc1cc(ccc1F)-c1cnc2[nH]c(=O)n(Cc3cncc(F)c3)c2c1
Show InChI InChI=1S/C19H14F2N4O/c1-11-4-13(2-3-16(11)21)14-6-17-18(23-8-14)24-19(26)25(17)10-12-5-15(20)9-22-7-12/h2-9H,10H2,1H3,(H,23,24,26)
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n/an/a 19n/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10617676 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%