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Patent code US10617680

Compile Data Set for Download or QSAR

Found 423 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM437273
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-1,4-dimethylpyridin-2...)
Show SMILES Cc1cc(=O)n(C)cc1-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C17H17N3O/c1-13-8-17(21)19(2)12-16(13)15-9-18-20(11-15)10-14-6-4-3-5-7-14/h3-9,11-12H,10H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437280
PNG
((S)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)...)
Show SMILES C[C@@H](c1ccccc1)n1cc(cn1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C17H17N3O/c1-13(14-6-4-3-5-7-14)20-12-16(10-18-20)15-8-9-17(21)19(2)11-15/h3-13H,1-2H3/t13-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437289
PNG
(5-(1-(1-(3-chlorophenyl)ethyl)-1H-pyrazol-4-yl)- 1...)
Show SMILES CC(c1cccc(Cl)c1)n1cc(cn1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C17H16ClN3O/c1-12(13-4-3-5-16(18)8-13)21-11-15(9-19-21)14-6-7-17(22)20(2)10-14/h3-12H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437297
PNG
(3-chloro-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-...)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C17H16ClN3O/c1-12(13-6-4-3-5-7-13)21-11-15(9-19-21)14-8-16(18)17(22)20(2)10-14/h3-12H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437315
PNG
(4-cyclobutoxy-1-methyl-5-(1-(1-phenylethyl)-1H- py...)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cn(C)c(=O)cc1OC1CCC1
Show InChI InChI=1S/C21H23N3O2/c1-15(16-7-4-3-5-8-16)24-13-17(12-22-24)19-14-23(2)21(25)11-20(19)26-18-9-6-10-18/h3-5,7-8,11-15,18H,6,9-10H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437316
PNG
(4-((1-acetylazetidin-3-yl)oxy)-1-methyl-5-(1-(1-ph...)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cn(C)c(=O)cc1OC1CN(C1)C(C)=O
Show InChI InChI=1S/C22H24N4O3/c1-15(17-7-5-4-6-8-17)26-11-18(10-23-26)20-14-24(3)22(28)9-21(20)29-19-12-25(13-19)16(2)27/h4-11,14-15,19H,12-13H2,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437331
PNG
(4-ethoxy-1-methyl-5-(1-(4-methylbenzyl)-1H- pyrazo...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(Cc2ccc(C)cc2)c1
Show InChI InChI=1S/C19H21N3O2/c1-4-24-18-9-19(23)21(3)13-17(18)16-10-20-22(12-16)11-15-7-5-14(2)6-8-15/h5-10,12-13H,4,11H2,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437333
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4- morpholin...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)N1CCOCC1
Show InChI InChI=1S/C20H22N4O2/c1-22-15-18(19(11-20(22)25)23-7-9-26-10-8-23)17-12-21-24(14-17)13-16-5-3-2-4-6-16/h2-6,11-12,14-15H,7-10,13H2,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437346
PNG
(1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)-n1ccc(c1)C#N
Show InChI InChI=1S/C21H17N5O/c1-24-15-19(20(9-21(24)27)25-8-7-17(10-22)12-25)18-11-23-26(14-18)13-16-5-3-2-4-6-16/h2-9,11-12,14-15H,13H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437355
PNG
(N-{1-[5-(1-Benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-...)
Show SMILES CC(=O)NC[C@@H]1CCN(C1)c1cc(=O)n(C)cc1-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C23H27N5O2/c1-17(29)24-11-19-8-9-27(13-19)22-10-23(30)26(2)16-21(22)20-12-25-28(15-20)14-18-6-4-3-5-7-18/h3-7,10,12,15-16,19H,8-9,11,13-14H2,1-2H3,(H,24,29)/t19-/m0/s1
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437368
PNG
(4-ethoxy-1-methyl-5-(1-(4-(1-methyl-1H-pyrazol-4-y...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(Cc2ccc(cc2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H23N5O2/c1-4-29-21-9-22(28)25(2)15-20(21)19-11-24-27(14-19)12-16-5-7-17(8-6-16)18-10-23-26(3)13-18/h5-11,13-15H,4,12H2,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437371
PNG
(5-(1-(3-bromobenzyl)-1H-pyrazol-4-yl)-4-ethoxy-1- ...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(Cc2cccc(Br)c2)c1
Show InChI InChI=1S/C18H18BrN3O2/c1-3-24-17-8-18(23)21(2)12-16(17)14-9-20-22(11-14)10-13-5-4-6-15(19)7-13/h4-9,11-12H,3,10H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437387
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-4-(isoxazol-3-yl)-1- ...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)-c1ccon1
Show InChI InChI=1S/C19H16N4O2/c1-22-13-17(16(9-19(22)24)18-7-8-25-21-18)15-10-20-23(12-15)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437402
PNG
(5-(1,3-dimethyl-1H-pyrazol-4-yl)-1-methyl-4- pheny...)
Show SMILES Cc1nn(C)cc1-c1cn(C)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C17H17N3O/c1-12-15(11-20(3)18-12)16-10-19(2)17(21)9-14(16)13-7-5-4-6-8-13/h4-11H,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437404
PNG
(5-(1-isopropyl-1H-pyrazol-4-yl)-1-methyl-4- phenyl...)
Show SMILES CC(C)n1cc(cn1)-c1cn(C)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C18H19N3O/c1-13(2)21-11-15(10-19-21)17-12-20(3)18(22)9-16(17)14-7-5-4-6-8-14/h4-13H,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437407
PNG
(2-(4-(1-methyl-6-oxo-4-phenyl-1,6-dihydropyridin-3...)
Show SMILES CCCNC(=O)Cn1cc(cn1)-c1cn(C)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C20H22N4O2/c1-3-9-21-19(25)14-24-12-16(11-22-24)18-13-23(2)20(26)10-17(18)15-7-5-4-6-8-15/h4-8,10-13H,3,9,14H2,1-2H3,(H,21,25)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437410
PNG
(4-cyclopropyl-1-methyl-5-(1-methyl-1H-pyrazol-4-yl...)
Show SMILES Cn1cc(cn1)-c1cn(C)c(=O)cc1C1CC1
Show InChI InChI=1S/C13H15N3O/c1-15-8-12(10-6-14-16(2)7-10)11(5-13(15)17)9-3-4-9/h5-9H,3-4H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437412
PNG
(5-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-1-methyl...)
Show SMILES Cn1cc(-c2cnn(CC3CC3)c2)c(cc1=O)-c1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-21-13-18(16-10-20-22(12-16)11-14-7-8-14)17(9-19(21)23)15-5-3-2-4-6-15/h2-6,9-10,12-14H,7-8,11H2,1H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437414
PNG
(4-[5-(1-Cyclopropylmethyl-1H-pyrazol-4-yl)-1-methy...)
Show SMILES CNC(=O)c1ccc(cc1)-c1cc(=O)n(C)cc1-c1cnn(CC2CC2)c1
Show InChI InChI=1S/C21H22N4O2/c1-22-21(27)16-7-5-15(6-8-16)18-9-20(26)24(2)13-19(18)17-10-23-25(12-17)11-14-3-4-14/h5-10,12-14H,3-4,11H2,1-2H3,(H,22,27)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437418
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1H-pyrazo...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O/c1-23-13-18(17(7-19(23)25)15-8-20-21-9-15)16-10-22-24(12-16)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H,20,21)
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437420
PNG
(4-[5-(1-Cyclopropylmethyl-1H-pyrazol-4-yl)-1-methy...)
Show SMILES Cn1cc(-c2cnn(CC3CC3)c2)c(cc1=O)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H19N3O3/c1-22-12-18(16-9-21-23(11-16)10-13-2-3-13)17(8-19(22)24)14-4-6-15(7-5-14)20(25)26/h4-9,11-13H,2-3,10H2,1H3,(H,25,26)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437437
PNG
(5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(CC2CC2(F)F)c1
Show InChI InChI=1S/C15H17F2N3O2/c1-3-22-13-4-14(21)19(2)9-12(13)10-6-18-20(7-10)8-11-5-15(11,16)17/h4,6-7,9,11H,3,5,8H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437452
PNG
(5-(3-amino-1-benzyl-1H-pyrazol-4-yl)-4-ethoxy-1- m...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cn(Cc2ccccc2)nc1N
Show InChI InChI=1S/C18H20N4O2/c1-3-24-16-9-17(23)21(2)11-14(16)15-12-22(20-18(15)19)10-13-7-5-4-6-8-13/h4-9,11-12H,3,10H2,1-2H3,(H2,19,20)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437460
PNG
(5'-(1-Benzyl-1H-pyrazol-4-yl)-1'-methyl-1H,1'H- [3...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C21H18N4O2/c1-24-14-19(18(9-21(24)27)16-7-8-20(26)22-10-16)17-11-23-25(13-17)12-15-5-3-2-4-6-15/h2-11,13-14H,12H2,1H3,(H,22,26)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437472
PNG
(2-[4-(1'-Methyl-6,6'-dioxo-1,6,1',6'-tetrahydro- [...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2C#N)c(cc1=O)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C21H15N5O2/c1-25-13-18(17(8-21(25)28)15-6-7-20(27)23-10-15)16-11-24-26(12-16)19-5-3-2-4-14(19)9-22/h2-8,10-13H,1H3,(H,23,27)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437480
PNG
(2-{4-[4-(4-Chloro-phenyl)-1-methyl-6-oxo-1,6-dihyd...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2C#N)c(cc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H15ClN4O/c1-26-14-20(19(10-22(26)28)15-6-8-18(23)9-7-15)17-12-25-27(13-17)21-5-3-2-4-16(21)11-24/h2-10,12-14H,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437486
PNG
(2-[4-(2'-Methoxy-1-methyl-6-oxo-1,6-dihydro- [4,4'...)
Show SMILES COc1cc(ccn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C#N
Show InChI InChI=1S/C22H17N5O2/c1-26-14-19(18(10-22(26)28)15-7-8-24-21(9-15)29-2)17-12-25-27(13-17)20-6-4-3-5-16(20)11-23/h3-10,12-14H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437491
PNG
(2-(4-(4-(4-chlorophenyl)-1-methyl-6-oxo-1,6- dihyd...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2C(O)=O)c(cc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H16ClN3O3/c1-25-13-19(18(10-21(25)27)14-6-8-16(23)9-7-14)15-11-24-26(12-15)20-5-3-2-4-17(20)22(28)29/h2-13H,1H3,(H,28,29)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437500
PNG
(2-[4-(6-Ethoxy-1'-methyl-6'-oxo-1',6'-dihydro- [3,...)
Show SMILES CCOc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C#N
Show InChI InChI=1S/C23H19N5O2/c1-3-30-22-9-8-17(12-25-22)19-10-23(29)27(2)15-20(19)18-13-26-28(14-18)21-7-5-4-6-16(21)11-24/h4-10,12-15H,3H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437503
PNG
(2-[4-(1'-Methyl-6'-oxo-1',6'-dihydro-[3,4']bipyrid...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2C#N)c(cc1=O)-c1cccnc1
Show InChI InChI=1S/C21H15N5O/c1-25-14-19(18(9-21(25)27)16-6-4-8-23-11-16)17-12-24-26(13-17)20-7-3-2-5-15(20)10-22/h2-9,11-14H,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437507
PNG
(2-{4-[4-(3-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihy...)
Show SMILES COc1cccc(c1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C#N
Show InChI InChI=1S/C23H18N4O2/c1-26-15-21(20(11-23(26)28)16-7-5-8-19(10-16)29-2)18-13-25-27(14-18)22-9-4-3-6-17(22)12-24/h3-11,13-15H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437519
PNG
(4-ethoxy-1-methyl-5-(1-(pyridin-2-yl)-1H-pyrazol-4...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccn1
Show InChI InChI=1S/C16H16N4O2/c1-3-22-14-8-16(21)19(2)11-13(14)12-9-18-20(10-12)15-6-4-5-7-17-15/h4-11H,3H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437528
PNG
(2-{4-[4-(4-Chloro-phenyl)-1-methyl-6-oxo-1,6-dihyd...)
Show SMILES COc1ccc(C#N)c(c1)-n1cc(cn1)-c1cn(C)c(=O)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H17ClN4O2/c1-27-14-21(20(10-23(27)29)15-3-6-18(24)7-4-15)17-12-26-28(13-17)22-9-19(30-2)8-5-16(22)11-25/h3-10,12-14H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437544
PNG
(2-fluoro-6-(4-(4-(3-methoxy-4-methylphenyl)-1-meth...)
Show SMILES COc1cc(ccc1C)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(F)c1C#N
Show InChI InChI=1S/C24H19FN4O2/c1-15-7-8-16(9-23(15)31-3)18-10-24(30)28(2)14-20(18)17-12-27-29(13-17)22-6-4-5-21(25)19(22)11-26/h4-10,12-14H,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437552
PNG
(4-(4-Chloro-phenyl)-5-[1-(2-methanesulfonyl-phenyl...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2S(C)(=O)=O)c(cc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClN3O3S/c1-25-14-19(18(11-22(25)27)15-7-9-17(23)10-8-15)16-12-24-26(13-16)20-5-3-4-6-21(20)30(2,28)29/h3-14H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437557
PNG
(2-(4-(4-(4-chlorophenyl)-1-methyl-6-oxo-1,6- dihyd...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2C(=O)NC#N)c(cc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H16ClN5O2/c1-28-13-20(19(10-22(28)30)15-6-8-17(24)9-7-15)16-11-27-29(12-16)21-5-3-2-4-18(21)23(31)26-14-25/h2-13H,1H3,(H,26,31)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437559
PNG
(N-cyano-2-(4-(1,1'-dimethyl-2',6-dioxo-1,1',2',6- ...)
Show SMILES Cn1ccc(cc1=O)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C(=O)NC#N
Show InChI InChI=1S/C23H18N6O3/c1-27-8-7-15(9-21(27)30)18-10-22(31)28(2)13-19(18)16-11-26-29(12-16)20-6-4-3-5-17(20)23(32)25-14-24/h3-13H,1-2H3,(H,25,32)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437563
PNG
(5-(1-(2-(1H-tetrazol-5-yl)phenyl)-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2-c2nnn[nH]2)c(cc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H16ClN7O/c1-29-13-19(18(10-21(29)31)14-6-8-16(23)9-7-14)15-11-24-30(12-15)20-5-3-2-4-17(20)22-25-27-28-26-22/h2-13H,1H3,(H,25,26,27,28)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437565
PNG
(4-(4-Fluoro-phenyl)-1-methyl-5-{1-[2-(1H-tetrazol-...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2-c2nnn[nH]2)c(cc1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H16FN7O/c1-29-13-19(18(10-21(29)31)14-6-8-16(23)9-7-14)15-11-24-30(12-15)20-5-3-2-4-17(20)22-25-27-28-26-22/h2-13H,1H3,(H,25,26,27,28)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437574
PNG
(6-methoxy-1'-methyl-5'-(1-(1-phenylethyl)-1H-pyraz...)
Show SMILES COc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)C(C)c1ccccc1
Show InChI InChI=1S/C23H22N4O2/c1-16(17-7-5-4-6-8-17)27-14-19(13-25-27)21-15-26(2)23(28)11-20(21)18-9-10-22(29-3)24-12-18/h4-16H,1-3H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437577
PNG
(4-(2-(ethylamino)pyrimidin-5-yl)-1-methyl-5-(1-(1-...)
Show SMILES CCNc1ncc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)C(C)c1ccccc1
Show InChI InChI=1S/C23H24N6O/c1-4-24-23-25-11-18(12-26-23)20-10-22(30)28(3)15-21(20)19-13-27-29(14-19)16(2)17-8-6-5-7-9-17/h5-16H,4H2,1-3H3,(H,24,25,26)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437580
PNG
(5-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-1,1'-dimeth...)
Show SMILES Cn1ccc(cc1=O)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN4O2/c1-24-8-7-14(9-20(24)27)16-10-21(28)25(2)13-17(16)15-11-23-26(12-15)19-6-4-3-5-18(19)22/h3-13H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437601
PNG
(2-chloro-6-(4-(1-methyl-4-(2-morpholinopyrimidin-5...)
Show SMILES Cn1cc(-c2cnn(c2)-c2cccc(Cl)c2C#N)c(cc1=O)-c1cnc(nc1)N1CCOCC1
Show InChI InChI=1S/C24H20ClN7O2/c1-30-15-20(17-13-29-32(14-17)22-4-2-3-21(25)19(22)10-26)18(9-23(30)33)16-11-27-24(28-12-16)31-5-7-34-8-6-31/h2-4,9,11-15H,5-8H2,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437603
PNG
(2-chloro-6-(4-(1-methyl-4-(2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ncc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(Cl)c1C#N
Show InChI InChI=1S/C25H23ClN8O/c1-31-6-8-33(9-7-31)25-28-12-17(13-29-25)19-10-24(35)32(2)16-21(19)18-14-30-34(15-18)23-5-3-4-22(26)20(23)11-27/h3-5,10,12-16H,6-9H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437608
PNG
(2-chloro-6-(4-(6-(ethylamino)-1'-methyl-6'-oxo-1',...)
Show SMILES CCNc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(Cl)c1C#N
Show InChI InChI=1S/C23H19ClN6O/c1-3-26-22-8-7-15(11-27-22)17-9-23(31)29(2)14-19(17)16-12-28-30(13-16)21-6-4-5-20(24)18(21)10-25/h4-9,11-14H,3H2,1-2H3,(H,26,27)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437609
PNG
(2-(4-(6-(cyclopentylamino)-1'-methyl-6'-oxo-1',6'-...)
Show SMILES Cn1cc(-c2cnn(c2)-c2cccc(F)c2C#N)c(cc1=O)-c1ccc(NC2CCCC2)nc1
Show InChI InChI=1S/C26H23FN6O/c1-32-16-22(18-14-30-33(15-18)24-8-4-7-23(27)21(24)12-28)20(11-26(32)34)17-9-10-25(29-13-17)31-19-5-2-3-6-19/h4,7-11,13-16,19H,2-3,5-6H2,1H3,(H,29,31)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437611
PNG
(2-chloro-6-{4-[6-(dimethylamino)-1'-methyl-6'-oxo-...)
Show SMILES CN(C)c1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(Cl)c1C#N
Show InChI InChI=1S/C23H19ClN6O/c1-28(2)22-8-7-15(11-26-22)17-9-23(31)29(3)14-19(17)16-12-27-30(13-16)21-6-4-5-20(24)18(21)10-25/h4-9,11-14H,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437612
PNG
(2-(4-{6-[(cyclopropylmethyl)amino]-1'-methyl-6'-ox...)
Show SMILES Cn1cc(-c2cnn(c2)-c2cccc(F)c2C#N)c(cc1=O)-c1ccc(NCC2CC2)nc1
Show InChI InChI=1S/C25H21FN6O/c1-31-15-21(18-13-30-32(14-18)23-4-2-3-22(26)20(23)10-27)19(9-25(31)33)17-7-8-24(29-12-17)28-11-16-5-6-16/h2-4,7-9,12-16H,5-6,11H2,1H3,(H,28,29)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437620
PNG
(2-chloro-6-(4-(6-(difluoromethoxy)-1'-methy-6'-oxo...)
Show SMILES Cn1cc(-c2cnn(c2)-c2cccc(Cl)c2C#N)c(cc1=O)-c1ccc(OC(F)F)nc1
Show InChI InChI=1S/C22H14ClF2N5O2/c1-29-12-17(14-10-28-30(11-14)19-4-2-3-18(23)16(19)8-26)15(7-21(29)31)13-5-6-20(27-9-13)32-22(24)25/h2-7,9-12,22H,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437627
PNG
(2-[4-[4-[6-(cyclopentoxy)-3-pyridyl]-1-methyl-6-ox...)
Show SMILES Cn1cc(-c2cnn(c2)-c2cccc(F)c2C#N)c(cc1=O)-c1ccc(OC2CCCC2)nc1
Show InChI InChI=1S/C26H22FN5O2/c1-31-16-22(18-14-30-32(15-18)24-8-4-7-23(27)21(24)12-28)20(11-26(31)33)17-9-10-25(29-13-17)34-19-5-2-3-6-19/h4,7-11,13-16,19H,2-3,5-6H2,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US10617680 (2020)

More data for this
Ligand-Target Pair
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