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Patent code US10617692

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM433323
PNG
(US10561657, Ruxolitinib | US10617692, Ruxolitinib)
Show SMILES N#CCC(C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a<10n/an/an/an/an/an/a



CENTAURUS BIOPHARMA CO.; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
A testing platform for kinase activity of JAK2 was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of th...


US Patent US10617692 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM437666
PNG
(US10617692, Compound III)
Show SMILES Nc1nn(cc1-c1ncnc2[nH]ccc12)C(CC#N)C1CCC(=O)C1
PDB

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UniProtKB/SwissProt

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DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



CENTAURUS BIOPHARMA CO.; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
A testing platform for kinase activity of JAK2 was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of th...


US Patent US10617692 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM437665
PNG
(US10617692, Compound II)
Show SMILES Nc1nn(cc1-c1ncnc2[nH]ccc12)C(CC#N)C1CCCC1O
PDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



CENTAURUS BIOPHARMA CO.; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
A testing platform for kinase activity of JAK2 was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of th...


US Patent US10617692 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM437667
PNG
(US10617692, Compound IV)
Show SMILES Nc1nn(cc1-c1ncnc2[nH]ccc12)C(CC#N)C1CCCC1=O
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<30n/an/an/an/an/an/a



CENTAURUS BIOPHARMA CO.; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
A testing platform for kinase activity of JAK2 was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of th...


US Patent US10617692 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%