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Patent code US10618886

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM437978
PNG
(US10618886, Compound I)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C22H24F5N3O2S/c1-16-28-21-10-9-19(33(23,24,25,26)27)15-20(21)22(31)30(16)17-5-7-18(8-6-17)32-14-4-13-29-11-2-3-12-29/h5-10,15H,2-4,11-14H2,1H3
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n/an/a 1.73n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM437978
PNG
(US10618886, Compound I)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C22H24F5N3O2S/c1-16-28-21-10-9-19(33(23,24,25,26)27)15-20(21)22(31)30(16)17-5-7-18(8-6-17)32-14-4-13-29-11-2-3-12-29/h5-10,15H,2-4,11-14H2,1H3
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n/an/a 3.05n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438108
PNG
(US10618886, Compound II)
Show SMILES C[C@H]1CCCN1CCCOc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C23H26F5N3O2S/c1-16-5-3-12-30(16)13-4-14-33-19-8-6-18(7-9-19)31-17(2)29-22-11-10-20(15-21(22)23(31)32)34(24,25,26,27)28/h6-11,15-16H,3-5,12-14H2,1-2H3/t16-/m0/s1
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n/an/a 3.18n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438114
PNG
(US10618886, Compound VII)
Show SMILES CC1CCN(CCCOc2ccc(cc2)-n2c(C)nc3ccc(cc3c2=O)S(F)(F)(F)(F)F)C1
Show InChI InChI=1S/C23H26F5N3O2S/c1-16-10-12-30(15-16)11-3-13-33-19-6-4-18(5-7-19)31-17(2)29-22-9-8-20(14-21(22)23(31)32)34(24,25,26,27)28/h4-9,14,16H,3,10-13,15H2,1-2H3
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n/an/a 3.44n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438108
PNG
(US10618886, Compound II)
Show SMILES C[C@H]1CCCN1CCCOc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C23H26F5N3O2S/c1-16-5-3-12-30(16)13-4-14-33-19-8-6-18(7-9-19)31-17(2)29-22-11-10-20(15-21(22)23(31)32)34(24,25,26,27)28/h6-11,15-16H,3-5,12-14H2,1-2H3/t16-/m0/s1
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n/an/a 3.63n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438111
PNG
(US10618886, Compound IX | US10618886, Compound V)
Show SMILES C[C@H]1CCCN(CCCOc2ccc(cc2)-n2c(C)nc3ccc(cc3c2=O)S(F)(F)(F)(F)F)C1
Show InChI InChI=1S/C24H28F5N3O2S/c1-17-5-3-12-31(16-17)13-4-14-34-20-8-6-19(7-9-20)32-18(2)30-23-11-10-21(15-22(23)24(32)33)35(25,26,27,28)29/h6-11,15,17H,3-5,12-14,16H2,1-2H3/t17-/m0/s1
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n/an/a 3.83n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438110
PNG
(US10618886, Compound IV)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C23H26F5N3O2S/c1-16-5-3-12-30(16)13-4-14-33-19-8-6-18(7-9-19)31-17(2)29-22-11-10-20(15-21(22)23(31)32)34(24,25,26,27)28/h6-11,15-16H,3-5,12-14H2,1-2H3/t16-/m1/s1
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n/an/a 3.87n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438115
PNG
(US10618886, Compound VIII)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C22H24F5N3O3S/c1-15-28-19-7-6-17(34(23,24,25,26)27)14-18(19)22(32)30(15)20-8-5-16(13-21(20)31)33-12-4-11-29-9-2-3-10-29/h5-8,13-14,31H,2-4,9-12H2,1H3
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n/an/a 4.81n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438119
PNG
(US10618886, Compound XII)
Show SMILES COc1cc(OCCCN2CCC(C)C2)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H28F5N3O3S/c1-16-9-11-31(15-16)10-4-12-35-18-5-8-22(23(13-18)34-3)32-17(2)30-21-7-6-19(14-20(21)24(32)33)36(25,26,27,28)29/h5-8,13-14,16H,4,9-12,15H2,1-3H3
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n/an/a 4.97n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438112
PNG
(US10618886, Compound VI)
Show SMILES COc1cc(OCCCN2CCC[C@H](C)C2)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C25H30F5N3O3S/c1-17-6-4-11-32(16-17)12-5-13-36-19-7-10-23(24(14-19)35-3)33-18(2)31-22-9-8-20(15-21(22)25(33)34)37(26,27,28,29)30/h7-10,14-15,17H,4-6,11-13,16H2,1-3H3/t17-/m0/s1
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n/an/a 5.36n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438112
PNG
(US10618886, Compound VI)
Show SMILES COc1cc(OCCCN2CCC[C@H](C)C2)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C25H30F5N3O3S/c1-17-6-4-11-32(16-17)12-5-13-36-19-7-10-23(24(14-19)35-3)33-18(2)31-22-9-8-20(15-21(22)25(33)34)37(26,27,28,29)30/h7-10,14-15,17H,4-6,11-13,16H2,1-3H3/t17-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438120
PNG
(US10618886, Compound XIII)
Show SMILES COc1cc(OCCCN2CCC[C@@H]2C)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H28F5N3O3S/c1-16-6-4-11-31(16)12-5-13-35-18-7-10-22(23(14-18)34-3)32-17(2)30-21-9-8-19(15-20(21)24(32)33)36(25,26,27,28)29/h7-10,14-16H,4-6,11-13H2,1-3H3/t16-/m0/s1
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n/an/a 5.63n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438115
PNG
(US10618886, Compound VIII)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C22H24F5N3O3S/c1-15-28-19-7-6-17(34(23,24,25,26)27)14-18(19)22(32)30(15)20-8-5-16(13-21(20)31)33-12-4-11-29-9-2-3-10-29/h5-8,13-14,31H,2-4,9-12H2,1H3
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n/an/a 6.11n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438111
PNG
(US10618886, Compound IX | US10618886, Compound V)
Show SMILES C[C@H]1CCCN(CCCOc2ccc(cc2)-n2c(C)nc3ccc(cc3c2=O)S(F)(F)(F)(F)F)C1
Show InChI InChI=1S/C24H28F5N3O2S/c1-17-5-3-12-31(16-17)13-4-14-34-20-8-6-19(7-9-20)32-18(2)30-23-11-10-21(15-22(23)24(32)33)35(25,26,27,28)29/h6-11,15,17H,3-5,12-14,16H2,1-2H3/t17-/m0/s1
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n/an/a 7.70n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438110
PNG
(US10618886, Compound IV)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C23H26F5N3O2S/c1-16-5-3-12-30(16)13-4-14-33-19-8-6-18(7-9-19)31-17(2)29-22-11-10-20(15-21(22)23(31)32)34(24,25,26,27)28/h6-11,15-16H,3-5,12-14H2,1-2H3/t16-/m1/s1
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n/an/a 8.15n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438117
PNG
(US10618886, Compound X)
Show SMILES COc1cc(OCCCN2CCC[C@H]2C)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H28F5N3O3S/c1-16-6-4-11-31(16)12-5-13-35-18-7-10-22(23(14-18)34-3)32-17(2)30-21-9-8-19(15-20(21)24(32)33)36(25,26,27,28)29/h7-10,14-16H,4-6,11-13H2,1-3H3/t16-/m1/s1
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n/an/a 9.10n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438114
PNG
(US10618886, Compound VII)
Show SMILES CC1CCN(CCCOc2ccc(cc2)-n2c(C)nc3ccc(cc3c2=O)S(F)(F)(F)(F)F)C1
Show InChI InChI=1S/C23H26F5N3O2S/c1-16-10-12-30(15-16)11-3-13-33-19-6-4-18(5-7-19)31-17(2)29-22-9-8-20(14-21(22)23(31)32)34(24,25,26,27)28/h4-9,14,16H,3,10-13,15H2,1-2H3
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n/an/a 10.5n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438120
PNG
(US10618886, Compound XIII)
Show SMILES COc1cc(OCCCN2CCC[C@@H]2C)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H28F5N3O3S/c1-16-6-4-11-31(16)12-5-13-35-18-7-10-22(23(14-18)34-3)32-17(2)30-21-9-8-19(15-20(21)24(32)33)36(25,26,27,28)29/h7-10,14-16H,4-6,11-13H2,1-3H3/t16-/m0/s1
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n/an/a 10.9n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438119
PNG
(US10618886, Compound XII)
Show SMILES COc1cc(OCCCN2CCC(C)C2)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H28F5N3O3S/c1-16-9-11-31(15-16)10-4-12-35-18-5-8-22(23(13-18)34-3)32-17(2)30-21-7-6-19(14-20(21)24(32)33)36(25,26,27,28)29/h5-8,13-14,16H,4,9-12,15H2,1-3H3
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n/an/a 17.6n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438111
PNG
(US10618886, Compound IX | US10618886, Compound V)
Show SMILES C[C@H]1CCCN(CCCOc2ccc(cc2)-n2c(C)nc3ccc(cc3c2=O)S(F)(F)(F)(F)F)C1
Show InChI InChI=1S/C24H28F5N3O2S/c1-17-5-3-12-31(16-17)13-4-14-34-20-8-6-19(7-9-20)32-18(2)30-23-11-10-21(15-22(23)24(32)33)35(25,26,27,28)29/h6-11,15,17H,3-5,12-14,16H2,1-2H3/t17-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438109
PNG
(US10618886, Compound III)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OCCCN2CCCCCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H28F5N3O2S/c1-18-30-23-12-11-21(35(25,26,27,28)29)17-22(23)24(33)32(18)19-7-9-20(10-8-19)34-16-6-15-31-13-4-2-3-5-14-31/h7-12,17H,2-6,13-16H2,1H3
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n/an/a 21.2n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438111
PNG
(US10618886, Compound IX | US10618886, Compound V)
Show SMILES C[C@H]1CCCN(CCCOc2ccc(cc2)-n2c(C)nc3ccc(cc3c2=O)S(F)(F)(F)(F)F)C1
Show InChI InChI=1S/C24H28F5N3O2S/c1-17-5-3-12-31(16-17)13-4-14-34-20-8-6-19(7-9-20)32-18(2)30-23-11-10-21(15-22(23)24(32)33)35(25,26,27,28)29/h6-11,15,17H,3-5,12-14,16H2,1-2H3/t17-/m0/s1
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n/an/a 36.5n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438109
PNG
(US10618886, Compound III)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OCCCN2CCCCCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H28F5N3O2S/c1-18-30-23-12-11-21(35(25,26,27,28)29)17-22(23)24(33)32(18)19-7-9-20(10-8-19)34-16-6-15-31-13-4-2-3-5-14-31/h7-12,17H,2-6,13-16H2,1H3
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n/an/a 39.6n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438125
PNG
(US10618886, Compound XX)
Show SMILES CN1CCC(CC1)C(=O)N1CCC(CC1)Oc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C27H31F5N4O3S/c1-18-33-25-8-7-23(40(28,29,30,31)32)17-24(25)27(38)36(18)20-3-5-21(6-4-20)39-22-11-15-35(16-12-22)26(37)19-9-13-34(2)14-10-19/h3-8,17,19,22H,9-16H2,1-2H3
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US Patent
n/an/a 50.5n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438117
PNG
(US10618886, Compound X)
Show SMILES COc1cc(OCCCN2CCC[C@H]2C)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H28F5N3O3S/c1-16-6-4-11-31(16)12-5-13-35-18-7-10-22(23(14-18)34-3)32-17(2)30-21-9-8-19(15-20(21)24(32)33)36(25,26,27,28)29/h7-10,14-16H,4-6,11-13H2,1-3H3/t16-/m1/s1
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n/an/a 52.5n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438121
PNG
(US10618886, Compound XIV)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCC(CC2)C2CC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H25F5N2O2S/c1-15-30-23-13-12-21(34(25,26,27,28)29)14-22(23)24(32)31(15)18-6-10-20(11-7-18)33-19-8-4-17(5-9-19)16-2-3-16/h6-7,10-14,16-17,19H,2-5,8-9H2,1H3
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US Patent
n/an/a 55.7n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438121
PNG
(US10618886, Compound XIV)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCC(CC2)C2CC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C24H25F5N2O2S/c1-15-30-23-13-12-21(34(25,26,27,28)29)14-22(23)24(32)31(15)18-6-10-20(11-7-18)33-19-8-4-17(5-9-19)16-2-3-16/h6-7,10-14,16-17,19H,2-5,8-9H2,1H3
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n/an/a 61.9n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438122
PNG
(US10618886, Compound XVI)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCC(CC2)C2CCCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C26H29F5N2O2S/c1-17-32-25-15-14-23(36(27,28,29,30)31)16-24(25)26(34)33(17)20-8-12-22(13-9-20)35-21-10-6-19(7-11-21)18-4-2-3-5-18/h8-9,12-16,18-19,21H,2-7,10-11H2,1H3
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n/an/a 116n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438122
PNG
(US10618886, Compound XVI)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCC(CC2)C2CCCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C26H29F5N2O2S/c1-17-32-25-15-14-23(36(27,28,29,30)31)16-24(25)26(34)33(17)20-8-12-22(13-9-20)35-21-10-6-19(7-11-21)18-4-2-3-5-18/h8-9,12-16,18-19,21H,2-7,10-11H2,1H3
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n/an/a 175n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438127
PNG
(US10618886, Compound XXII)
Show SMILES COc1cc(OC2CCN(CC2)C(=O)C2CCOCC2)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C27H30F5N3O5S/c1-17-33-23-5-4-21(41(28,29,30,31)32)16-22(23)27(37)35(17)24-6-3-20(15-25(24)38-2)40-19-7-11-34(12-8-19)26(36)18-9-13-39-14-10-18/h3-6,15-16,18-19H,7-14H2,1-2H3
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n/an/a 229n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438127
PNG
(US10618886, Compound XXII)
Show SMILES COc1cc(OC2CCN(CC2)C(=O)C2CCOCC2)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C27H30F5N3O5S/c1-17-33-23-5-4-21(41(28,29,30,31)32)16-22(23)27(37)35(17)24-6-3-20(15-25(24)38-2)40-19-7-11-34(12-8-19)26(36)18-9-13-39-14-10-18/h3-6,15-16,18-19H,7-14H2,1-2H3
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n/an/a 242n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438126
PNG
(US10618886, Compound XXI)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCN(CC2)C(=O)C2CCOCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C26H28F5N3O4S/c1-17-32-24-7-6-22(39(27,28,29,30)31)16-23(24)26(36)34(17)19-2-4-20(5-3-19)38-21-8-12-33(13-9-21)25(35)18-10-14-37-15-11-18/h2-7,16,18,21H,8-15H2,1H3
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n/an/a 286n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438125
PNG
(US10618886, Compound XX)
Show SMILES CN1CCC(CC1)C(=O)N1CCC(CC1)Oc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F
Show InChI InChI=1S/C27H31F5N4O3S/c1-18-33-25-8-7-23(40(28,29,30,31)32)17-24(25)27(38)36(18)20-3-5-21(6-4-20)39-22-11-15-35(16-12-22)26(37)19-9-13-34(2)14-10-19/h3-8,17,19,22H,9-16H2,1-2H3
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n/an/a 814n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438124
PNG
(US10618886, Compound XIX)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCN(CC2)C(=O)C2CCCCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C27H30F5N3O3S/c1-18-33-25-12-11-23(39(28,29,30,31)32)17-24(25)27(37)35(18)20-7-9-21(10-8-20)38-22-13-15-34(16-14-22)26(36)19-5-3-2-4-6-19/h7-12,17,19,22H,2-6,13-16H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438124
PNG
(US10618886, Compound XIX)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCN(CC2)C(=O)C2CCCCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C27H30F5N3O3S/c1-18-33-25-12-11-23(39(28,29,30,31)32)17-24(25)27(37)35(18)20-7-9-21(10-8-20)38-22-13-15-34(16-14-22)26(36)19-5-3-2-4-6-19/h7-12,17,19,22H,2-6,13-16H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
Histamine H3 Receptor


(Homo sapiens (Human))		BDBM438126
PNG
(US10618886, Compound XXI)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC2CCN(CC2)C(=O)C2CCOCC2)cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C26H28F5N3O4S/c1-17-32-24-7-6-22(39(27,28,29,30)31)16-23(24)26(36)34(17)19-2-4-20(5-3-19)38-21-8-12-33(13-9-21)25(35)18-10-14-37-15-11-18/h2-7,16,18,21H,8-15H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



XW LABORATORIES INC.

US Patent


Assay Description
Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...

US Patent US10618886 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%