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Patent code US10618900

Compile Data Set for Download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50084137
PNG
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccccc1
Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
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Patents


Similars

US Patent
n/an/a 4.00E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438356
PNG
(2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(pyri...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H12FN3OS/c1-12-21-15(11-24-12)6-4-13-5-7-17(19)16(9-13)18(23)22-14-3-2-8-20-10-14/h2-3,5,7-11H,1H3,(H,22,23)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438356
PNG
(2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(pyri...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H12FN3OS/c1-12-21-15(11-24-12)6-4-13-5-7-17(19)16(9-13)18(23)22-14-3-2-8-20-10-14/h2-3,5,7-11H,1H3,(H,22,23)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438360
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-((2...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C22H17FN2OS/c1-15-24-19(14-27-15)8-6-16-7-9-21(23)20(12-16)22(26)25-11-10-17-4-2-3-5-18(17)13-25/h2-5,7,9,12,14H,10-11,13H2,1H3
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n/an/a 6.65E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438360
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-((2...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C22H17FN2OS/c1-15-24-19(14-27-15)8-6-16-7-9-21(23)20(12-16)22(26)25-11-10-17-4-2-3-5-18(17)13-25/h2-5,7,9,12,14H,10-11,13H2,1H3
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n/an/a 6.65E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438351
PNG
(2-chloro-N-(4-fluorophenyl)-5-((2-methyl- thiazol-...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(Cl)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H12ClFN2OS/c1-12-22-16(11-25-12)6-2-13-3-9-18(20)17(10-13)19(24)23-15-7-4-14(21)5-8-15/h3-5,7-11H,1H3,(H,23,24)
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n/an/a 7.31E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438351
PNG
(2-chloro-N-(4-fluorophenyl)-5-((2-methyl- thiazol-...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(Cl)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H12ClFN2OS/c1-12-22-16(11-25-12)6-2-13-3-9-18(20)17(10-13)19(24)23-15-7-4-14(21)5-8-15/h3-5,7-11H,1H3,(H,23,24)
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n/an/a 7.31E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438349
PNG
(2-fluoro-N-(4-fluorophenyl)-5-((2-methyl- thiZaol-...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H12F2N2OS/c1-12-22-16(11-25-12)6-2-13-3-9-18(21)17(10-13)19(24)23-15-7-4-14(20)5-8-15/h3-5,7-11H,1H3,(H,23,24)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438349
PNG
(2-fluoro-N-(4-fluorophenyl)-5-((2-methyl- thiZaol-...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H12F2N2OS/c1-12-22-16(11-25-12)6-2-13-3-9-18(21)17(10-13)19(24)23-15-7-4-14(20)5-8-15/h3-5,7-11H,1H3,(H,23,24)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438348
PNG
(2-fluoro-5-(pyridin-2-ethynyl)-N-(4- fluorophenyl)...)
Show SMILES Fc1ccc(NC(=O)c2cc(ccc2F)C#Cc2ccccn2)cc1
Show InChI InChI=1S/C20H12F2N2O/c21-15-6-9-17(10-7-15)24-20(25)18-13-14(5-11-19(18)22)4-8-16-3-1-2-12-23-16/h1-3,5-7,9-13H,(H,24,25)
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n/an/a 1.39E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438348
PNG
(2-fluoro-5-(pyridin-2-ethynyl)-N-(4- fluorophenyl)...)
Show SMILES Fc1ccc(NC(=O)c2cc(ccc2F)C#Cc2ccccn2)cc1
Show InChI InChI=1S/C20H12F2N2O/c21-15-6-9-17(10-7-15)24-20(25)18-13-14(5-11-19(18)22)4-8-16-3-1-2-12-23-16/h1-3,5-7,9-13H,(H,24,25)
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n/an/a 1.39E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438367
PNG
(3-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H13N3OS/c1-13-20-17(12-23-13)8-7-14-4-2-5-15(10-14)18(22)21-16-6-3-9-19-11-16/h2-6,9-12H,1H3,(H,21,22)
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n/an/a 1.42E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438367
PNG
(3-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H13N3OS/c1-13-20-17(12-23-13)8-7-14-4-2-5-15(10-14)18(22)21-16-6-3-9-19-11-16/h2-6,9-12H,1H3,(H,21,22)
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n/an/a 1.42E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438364
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(3-((2- methyl-t...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C22H18N2OS/c1-16-23-21(15-26-16)10-9-17-5-4-8-19(13-17)22(25)24-12-11-18-6-2-3-7-20(18)14-24/h2-8,13,15H,11-12,14H2,1H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438364
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(3-((2- methyl-t...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C22H18N2OS/c1-16-23-21(15-26-16)10-9-17-5-4-8-19(13-17)22(25)24-12-11-18-6-2-3-7-20(18)14-24/h2-8,13,15H,11-12,14H2,1H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438368
PNG
(3-((2-methylthiazol-4-ylethynyl)-N- phenylbenzamid...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H14N2OS/c1-14-20-18(13-23-14)11-10-15-6-5-7-16(12-15)19(22)21-17-8-3-2-4-9-17/h2-9,12-13H,1H3,(H,21,22)
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n/an/a 1.48E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438368
PNG
(3-((2-methylthiazol-4-ylethynyl)-N- phenylbenzamid...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H14N2OS/c1-14-20-18(13-23-14)11-10-15-6-5-7-16(12-15)19(22)21-17-8-3-2-4-9-17/h2-9,12-13H,1H3,(H,21,22)
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n/an/a 1.48E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438359
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-(py...)
Show SMILES Fc1ccc(cc1C(=O)N1CCc2ccccc2C1)C#Cc1ccccn1
Show InChI InChI=1S/C23H17FN2O/c24-22-11-9-17(8-10-20-7-3-4-13-25-20)15-21(22)23(27)26-14-12-18-5-1-2-6-19(18)16-26/h1-7,9,11,13,15H,12,14,16H2
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n/an/a 1.52E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438359
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-(py...)
Show SMILES Fc1ccc(cc1C(=O)N1CCc2ccccc2C1)C#Cc1ccccn1
Show InChI InChI=1S/C23H17FN2O/c24-22-11-9-17(8-10-20-7-3-4-13-25-20)15-21(22)23(27)26-14-12-18-5-1-2-6-19(18)16-26/h1-7,9,11,13,15H,12,14,16H2
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n/an/a 1.52E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438355
PNG
(2-fluoro-5-(pyridin-2-ethynyl)-N- (pyridin-3-yl)be...)
Show SMILES Fc1ccc(cc1C(=O)Nc1cccnc1)C#Cc1ccccn1
Show InChI InChI=1S/C19H12FN3O/c20-18-9-7-14(6-8-15-4-1-2-11-22-15)12-17(18)19(24)23-16-5-3-10-21-13-16/h1-5,7,9-13H,(H,23,24)
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n/an/a 1.94E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438355
PNG
(2-fluoro-5-(pyridin-2-ethynyl)-N- (pyridin-3-yl)be...)
Show SMILES Fc1ccc(cc1C(=O)Nc1cccnc1)C#Cc1ccccn1
Show InChI InChI=1S/C19H12FN3O/c20-18-9-7-14(6-8-15-4-1-2-11-22-15)12-17(18)19(24)23-16-5-3-10-21-13-16/h1-5,7,9-13H,(H,23,24)
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n/an/a 1.94E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438350
PNG
(2-chloro-N-(4-fluorophenyl)-5-(pyridin-2- ethynyl)...)
Show SMILES Fc1ccc(NC(=O)c2cc(ccc2Cl)C#Cc2ccccn2)cc1
Show InChI InChI=1S/C20H12ClFN2O/c21-19-11-5-14(4-8-16-3-1-2-12-23-16)13-18(19)20(25)24-17-9-6-15(22)7-10-17/h1-3,5-7,9-13H,(H,24,25)
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n/an/a 2.03E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438350
PNG
(2-chloro-N-(4-fluorophenyl)-5-(pyridin-2- ethynyl)...)
Show SMILES Fc1ccc(NC(=O)c2cc(ccc2Cl)C#Cc2ccccn2)cc1
Show InChI InChI=1S/C20H12ClFN2O/c21-19-11-5-14(4-8-16-3-1-2-12-23-16)13-18(19)20(25)24-17-9-6-15(22)7-10-17/h1-3,5-7,9-13H,(H,24,25)
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n/an/a 2.03E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438373
PNG
(3-((2-methylthiazol-4-ylethynyl)-N-(4- (trifluorom...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H13F3N2OS/c1-13-24-18(12-27-13)8-5-14-3-2-4-15(11-14)19(26)25-17-9-6-16(7-10-17)20(21,22)23/h2-4,6-7,9-12H,1H3,(H,25,26)
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n/an/a 2.92E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438366
PNG
((1-methyl-3,4-dihydro-isoquinolin-2(1H- yl-3-((2-m...)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1cccc(c1)C#Cc1csc(C)n1
Show InChI InChI=1S/C23H20N2OS/c1-16-22-9-4-3-7-19(22)12-13-25(16)23(26)20-8-5-6-18(14-20)10-11-21-15-27-17(2)24-21/h3-9,14-16H,12-13H2,1-2H3
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n/an/a 3.26E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438362
PNG
((2-fluoro-5-((2-methyl-thiazol-4-yl) ethynyl)pheny...)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1cc(ccc1F)C#Cc1csc(C)n1
Show InChI InChI=1S/C23H19FN2OS/c1-15-20-6-4-3-5-18(20)11-12-26(15)23(27)21-13-17(8-10-22(21)24)7-9-19-14-28-16(2)25-19/h3-6,8,10,13-15H,11-12H2,1-2H3
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n/an/a 3.80E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438362
PNG
((2-fluoro-5-((2-methyl-thiazol-4-yl) ethynyl)pheny...)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1cc(ccc1F)C#Cc1csc(C)n1
Show InChI InChI=1S/C23H19FN2OS/c1-15-20-6-4-3-5-18(20)11-12-26(15)23(27)21-13-17(8-10-22(21)24)7-9-19-14-28-16(2)25-19/h3-6,8,10,13-15H,11-12H2,1-2H3
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n/an/a 3.80E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438363
PNG
(N-(4-fluorophenyl)-3-((2-methylthiazol-4- yl)ethyn...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H13FN2OS/c1-13-21-18(12-24-13)8-5-14-3-2-4-15(11-14)19(23)22-17-9-6-16(20)7-10-17/h2-4,6-7,9-12H,1H3,(H,22,23)
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n/an/a 4.06E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438358
PNG
(N-(4-cyanophenyl)2-fluoro-5-((2-methyl- thiazol-4-...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C20H12FN3OS/c1-13-23-17(12-26-13)8-2-14-5-9-19(21)18(10-14)20(25)24-16-6-3-15(11-22)4-7-16/h3-7,9-10,12H,1H3,(H,24,25)
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n/an/a 5.35E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438361
PNG
((2-fluoro-5-(pyridin-2-ylethynyl)phenyl) (1-methyl...)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1cc(ccc1F)C#Cc1ccccn1
Show InChI InChI=1S/C24H19FN2O/c1-17-21-8-3-2-6-19(21)13-15-27(17)24(28)22-16-18(10-12-23(22)25)9-11-20-7-4-5-14-26-20/h2-8,10,12,14,16-17H,13,15H2,1H3
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n/an/a 7.13E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438357
PNG
(N-(4-cyanophenyl)-2-fluoro-5-(pyridin-2- ethynyl)b...)
Show SMILES Fc1ccc(cc1C(=O)Nc1ccc(cc1)C#N)C#Cc1ccccn1
Show InChI InChI=1S/C21H12FN3O/c22-20-11-7-15(4-8-17-3-1-2-12-24-17)13-19(20)21(26)25-18-9-5-16(14-23)6-10-18/h1-3,5-7,9-13H,(H,25,26)
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n/an/a 8.65E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438365
PNG
(N-(4-cyanophenyl)-3-((2-methylthiazol-4- yl)ethyny...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C20H13N3OS/c1-14-22-19(13-25-14)10-5-15-3-2-4-17(11-15)20(24)23-18-8-6-16(12-21)7-9-18/h2-4,6-9,11,13H,1H3,(H,23,24)
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n/an/a 8.66E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438374
PNG
(US10618900, No. JNJ16259685)
Show SMILES COC1CCC(CC1)C(=O)c1ccc2nc3OCCCc3cc2c1
Show InChI InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3
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n/an/a 9.12E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438359
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-(py...)
Show SMILES Fc1ccc(cc1C(=O)N1CCc2ccccc2C1)C#Cc1ccccn1
Show InChI InChI=1S/C23H17FN2O/c24-22-11-9-17(8-10-20-7-3-4-13-25-20)15-21(22)23(27)26-14-12-18-5-1-2-6-19(18)16-26/h1-7,9,11,13,15H,12,14,16H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438350
PNG
(2-chloro-N-(4-fluorophenyl)-5-(pyridin-2- ethynyl)...)
Show SMILES Fc1ccc(NC(=O)c2cc(ccc2Cl)C#Cc2ccccn2)cc1
Show InChI InChI=1S/C20H12ClFN2O/c21-19-11-5-14(4-8-16-3-1-2-12-23-16)13-18(19)20(25)24-17-9-6-15(22)7-10-17/h1-3,5-7,9-13H,(H,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438367
PNG
(3-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H13N3OS/c1-13-20-17(12-23-13)8-7-14-4-2-5-15(10-14)18(22)21-16-6-3-9-19-11-16/h2-6,9-12H,1H3,(H,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438373
PNG
(3-((2-methylthiazol-4-ylethynyl)-N-(4- (trifluorom...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H13F3N2OS/c1-13-24-18(12-27-13)8-5-14-3-2-4-15(11-14)19(26)25-17-9-6-16(7-10-17)20(21,22)23/h2-4,6-7,9-12H,1H3,(H,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438356
PNG
(2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(pyri...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H12FN3OS/c1-12-21-15(11-24-12)6-4-13-5-7-17(19)16(9-13)18(23)22-14-3-2-8-20-10-14/h2-3,5,7-11H,1H3,(H,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438360
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-((2...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C22H17FN2OS/c1-15-24-19(14-27-15)8-6-16-7-9-21(23)20(12-16)22(26)25-11-10-17-4-2-3-5-18(17)13-25/h2-5,7,9,12,14H,10-11,13H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438362
PNG
((2-fluoro-5-((2-methyl-thiazol-4-yl) ethynyl)pheny...)
Show SMILES CC1N(CCc2ccccc12)C(=O)c1cc(ccc1F)C#Cc1csc(C)n1
Show InChI InChI=1S/C23H19FN2OS/c1-15-20-6-4-3-5-18(20)11-12-26(15)23(27)21-13-17(8-10-22(21)24)7-9-19-14-28-16(2)25-19/h3-6,8,10,13-15H,11-12H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438348
PNG
(2-fluoro-5-(pyridin-2-ethynyl)-N-(4- fluorophenyl)...)
Show SMILES Fc1ccc(NC(=O)c2cc(ccc2F)C#Cc2ccccn2)cc1
Show InChI InChI=1S/C20H12F2N2O/c21-15-6-9-17(10-7-15)24-20(25)18-13-14(5-11-19(18)22)4-8-16-3-1-2-12-23-16/h1-3,5-7,9-13H,(H,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438351
PNG
(2-chloro-N-(4-fluorophenyl)-5-((2-methyl- thiazol-...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(Cl)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H12ClFN2OS/c1-12-22-16(11-25-12)6-2-13-3-9-18(20)17(10-13)19(24)23-15-7-4-14(21)5-8-15/h3-5,7-11H,1H3,(H,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438368
PNG
(3-((2-methylthiazol-4-ylethynyl)-N- phenylbenzamid...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H14N2OS/c1-14-20-18(13-23-14)11-10-15-6-5-7-16(12-15)19(22)21-17-8-3-2-4-9-17/h2-9,12-13H,1H3,(H,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438355
PNG
(2-fluoro-5-(pyridin-2-ethynyl)-N- (pyridin-3-yl)be...)
Show SMILES Fc1ccc(cc1C(=O)Nc1cccnc1)C#Cc1ccccn1
Show InChI InChI=1S/C19H12FN3O/c20-18-9-7-14(6-8-15-4-1-2-11-22-15)12-17(18)19(24)23-16-5-3-10-21-13-16/h1-5,7,9-13H,(H,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438364
PNG
((3,4-dihydro-isoquinolin-2(1H)-yl)(3-((2- methyl-t...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C22H18N2OS/c1-16-23-21(15-26-16)10-9-17-5-4-8-19(13-17)22(25)24-12-11-18-6-2-3-7-20(18)14-24/h2-8,13,15H,11-12,14H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM438349
PNG
(2-fluoro-N-(4-fluorophenyl)-5-((2-methyl- thiZaol-...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(F)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H12F2N2OS/c1-12-22-16(11-25-12)6-2-13-3-9-18(21)17(10-13)19(24)23-15-7-4-14(20)5-8-15/h3-5,7-11H,1H3,(H,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438353
PNG
(N-(4-fluorophenyl)-2-methyl-5-(pyridin-2- ethynyl)...)
Show SMILES Cc1ccc(cc1C(=O)Nc1ccc(F)cc1)C#Cc1ccccn1
Show InChI InChI=1S/C21H15FN2O/c1-15-5-6-16(7-10-18-4-2-3-13-23-18)14-20(15)21(25)24-19-11-8-17(22)9-12-19/h2-6,8-9,11-14H,1H3,(H,24,25)
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n/an/a 1.04E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438354
PNG
(N-(4-fluorophenyl)-2-methyl-5-((2-methyl- thiazol-...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(C)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H15FN2OS/c1-13-3-4-15(5-8-18-12-25-14(2)22-18)11-19(13)20(24)23-17-9-6-16(21)7-10-17/h3-4,6-7,9-12H,1-2H3,(H,23,24)
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n/an/a 1.09E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438369
PNG
(N-(3-fluorophenyl)-3-((2-methylthiazol-4- yl)ethyn...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C19H13FN2OS/c1-13-21-18(12-24-13)9-8-14-4-2-5-15(10-14)19(23)22-17-7-3-6-16(20)11-17/h2-7,10-12H,1H3,(H,22,23)
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n/an/a 1.33E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438370
PNG
(N-(3-cyanophenyl)-3-((2-methylthiazol-4- yl)ethyny...)
Show SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C20H13N3OS/c1-14-22-19(13-25-14)9-8-15-4-2-6-17(10-15)20(24)23-18-7-3-5-16(11-18)12-21/h2-7,10-11,13H,1H3,(H,23,24)
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n/an/a 1.34E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM438352
PNG
(2-fluoro-N-(4-fluorophenyl)-5-(pyridin-4- ethynyl)...)
Show SMILES Fc1ccc(NC(=O)c2cc(ccc2F)C#Cc2ccncc2)cc1
Show InChI InChI=1S/C20H12F2N2O/c21-16-4-6-17(7-5-16)24-20(25)18-13-15(3-8-19(18)22)2-1-14-9-11-23-12-10-14/h3-13H,(H,24,25)
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n/an/a 3.82E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50071375
PNG
(CHEMBL3410223 | US10618900, No. CTEP)
Show SMILES Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H13ClF3N3O/c1-12-17(8-3-14-9-10-24-18(20)11-14)25-13(2)26(12)15-4-6-16(7-5-15)27-19(21,22)23/h4-7,9-11H,1-2H3
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US Patent
n/an/a 5.39E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...


US Patent US10618900 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%