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Patent code US10618902

Compile Data Set for Download or QSAR

Found 256 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438617
PNG
(US10618902, Compound I-298)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)n(CC3CCOC3)c2nc1=O
Show InChI InChI=1S/C27H29Cl2N5O6/c1-4-21(35)31-17-12-40-13-18(17)32-27-30-9-15-7-16(22-23(28)19(37-2)8-20(38-3)24(22)29)26(36)33-25(15)34(27)10-14-5-6-39-11-14/h4,7-9,14,17-18H,1,5-6,10-13H2,2-3H3,(H,30,32)(H,31,35)/t14?,17-,18+/m0/s1
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438623
PNG
(US10618902, Compound I-304)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)n(CCF)c2nc1=O
Show InChI InChI=1S/C24H24Cl2FN5O5/c1-4-18(33)29-14-10-37-11-15(14)30-24-28-9-12-7-13(23(34)31-22(12)32(24)6-5-27)19-20(25)16(35-2)8-17(36-3)21(19)26/h4,7-9,14-15H,1,5-6,10-11H2,2-3H3,(H,28,30)(H,29,33)/t14-,15+/m0/s1
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88561
PNG
(US10189794, Compound I-3 | US10618902, Compound I-...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H26Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h4-15H,1,16-17H2,2-3H3,(H,34,39)(H,33,35,36)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88685
PNG
(US10189794, Compound I-43 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CCCNC2)C1=O
Show InChI InChI=1S/C28H31N7O4/c1-4-25(36)31-23-9-5-6-10-24(23)32-27-30-15-18-17-34(20-12-21(38-2)14-22(13-20)39-3)28(37)35(26(18)33-27)19-8-7-11-29-16-19/h4-6,9-10,12-15,19,29H,1,7-8,11,16-17H2,2-3H3,(H,31,36)(H,30,32,33)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM89503
PNG
(US10189794, Compound I-48 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC#N)C1=O
Show InChI InChI=1S/C25H23N7O4/c1-4-22(33)28-20-7-5-6-8-21(20)29-24-27-14-16-15-32(25(34)31(10-9-26)23(16)30-24)17-11-18(35-2)13-19(12-17)36-3/h4-8,11-14H,1,10,15H2,2-3H3,(H,28,33)(H,27,29,30)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91649
PNG
(US10189794, Compound I-55 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2ccc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)cc2N(C)C1=O
Show InChI InChI=1S/C32H36N6O5/c1-6-31(40)34-29-18-24(37-13-11-36(12-14-37)21(2)39)9-10-28(29)33-23-8-7-22-20-38(32(41)35(3)30(22)15-23)25-16-26(42-4)19-27(17-25)43-5/h6-10,15-19,33H,1,11-14,20H2,2-5H3,(H,34,40)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92533
PNG
(US10189794, Compound I-78 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(ccc3NC(=O)C=C)-c3nccs3)nc2N(C)C1=O
Show InChI InChI=1S/C27H25N7O4S/c1-5-23(35)30-21-7-6-16(25-28-8-9-39-25)10-22(21)31-26-29-14-17-15-34(27(36)33(2)24(17)32-26)18-11-19(37-3)13-20(12-18)38-4/h5-14H,1,15H2,2-4H3,(H,30,35)(H,29,31,32)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92734
PNG
(US10189794, Compound I-87 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2ccnc(N)c2)C1=O
Show InChI InChI=1S/C29H28N8O4/c1-4-26(38)33-23-7-5-6-8-24(23)34-28-32-15-19-17-36(20-12-21(40-2)14-22(13-20)41-3)29(39)37(27(19)35-28)16-18-9-10-31-25(30)11-18/h4-15H,1,16-17H2,2-3H3,(H2,30,31)(H,33,38)(H,32,34,35)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM93378
PNG
(US10189794, Compound I-95 | US10618902, Compound I...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H28Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5,10-11,14-15H,1,6-9,12H2,2-4H3,(H,28,33)(H,27,29,30)/t14-,15+/m0/s1
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94660
PNG
(US10189794, Compound I-98 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CC2)C1=O
Show InChI InChI=1S/C27H28N6O4/c1-4-24(34)29-22-7-5-6-8-23(22)30-26-28-14-18-16-32(19-11-20(36-2)13-21(12-19)37-3)27(35)33(25(18)31-26)15-17-9-10-17/h4-8,11-14,17H,1,9-10,15-16H2,2-3H3,(H,29,34)(H,28,30,31)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101115
PNG
(US10189794, Compound I-102 | US10618902, Compound ...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCF)C1=O
Show InChI InChI=1S/C25H25FN6O4/c1-4-22(33)28-20-7-5-6-8-21(20)29-24-27-14-16-15-32(25(34)31(10-9-26)23(16)30-24)17-11-18(35-2)13-19(12-17)36-3/h4-8,11-14H,1,9-10,15H2,2-3H3,(H,28,33)(H,27,29,30)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101124
PNG
(US10189794, Compound I-104 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC(F)F)C1=O
Show InChI InChI=1S/C25H23ClF2N6O4/c1-4-21(35)30-16-7-5-6-8-17(16)31-24-29-11-14-12-33(25(36)34(13-20(27)28)23(14)32-24)18-9-15(37-2)10-19(38-3)22(18)26/h4-11,20H,1,12-13H2,2-3H3,(H,30,35)(H,29,31,32)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101133
PNG
(US10189794, Compound I-108 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(F)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H23FN6O4/c1-5-20(32)27-16-8-6-7-9-17(16)28-23-26-12-14-13-31(24(33)30(2)22(14)29-23)18-10-15(34-3)11-19(35-4)21(18)25/h5-12H,1,13H2,2-4H3,(H,27,32)(H,26,28,29)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101135
PNG
(US10189794, Compound I-110 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCF)C1=O
Show InChI InChI=1S/C25H24ClFN6O4/c1-4-21(34)29-17-7-5-6-8-18(17)30-24-28-13-15-14-33(25(35)32(10-9-27)23(15)31-24)19-11-16(36-2)12-20(37-3)22(19)26/h4-8,11-13H,1,9-10,14H2,2-3H3,(H,29,34)(H,28,30,31)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM94662
PNG
(US10189794, Compound I-112 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C23H26Cl2N6O4/c1-5-17(32)27-13-7-6-8-14(13)28-22-26-10-12-11-31(23(33)30(2)21(12)29-22)20-18(24)15(34-3)9-16(35-4)19(20)25/h5,9-10,13-14H,1,6-8,11H2,2-4H3,(H,27,32)(H,26,28,29)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM96842
PNG
(US10189794, Compound I-144 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3ccc(F)c(N)c3)C2=O)c1Cl
Show InChI InChI=1S/C30H26Cl2FN7O4/c1-4-24(41)36-20-7-5-6-8-21(20)37-29-35-13-17-15-39(27-25(31)22(43-2)12-23(44-3)26(27)32)30(42)40(28(17)38-29)14-16-9-10-18(33)19(34)11-16/h4-13H,1,14-15,34H2,2-3H3,(H,36,41)(H,35,37,38)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98637
PNG
(US10189794, Compound I-150 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)C(=O)NC4CCN(C)CC4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C31H34Cl2N8O5/c1-6-24(42)36-21-13-17(29(43)35-19-9-11-39(2)12-10-19)7-8-20(21)37-30-34-15-18-16-41(31(44)40(3)28(18)38-30)27-25(32)22(45-4)14-23(46-5)26(27)33/h6-8,13-15,19H,1,9-12,16H2,2-5H3,(H,35,43)(H,36,42)(H,34,37,38)
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n/an/a<500n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM98639
PNG
(US10189794, Compound I-152 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(Cc3cn[nH]c3)C2=O)c1Cl
PDB

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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99850
PNG
(US10189794, Compound I-196 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CC(=O)NCC4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C23H25Cl2N7O5/c1-5-16(33)28-13-9-26-17(34)6-12(13)29-22-27-8-11-10-32(23(35)31(2)21(11)30-22)20-18(24)14(36-3)7-15(37-4)19(20)25/h5,7-8,12-13H,1,6,9-10H2,2-4H3,(H,26,34)(H,28,33)(H,27,29,30)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM99975
PNG
(US10189794, Compound I-201 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CN(CC4NC(=O)C=C)c4ccncn4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C26H27Cl2N9O4/c1-5-20(38)32-15-11-36(19-6-7-29-13-31-19)12-16(15)33-25-30-9-14-10-37(26(39)35(2)24(14)34-25)23-21(27)17(40-3)8-18(41-4)22(23)28/h5-9,13,15-16H,1,10-12H2,2-4H3,(H,32,38)(H,30,33,34)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100380
PNG
(US10189794, Compound I-212 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(CC3CC3)C2=O)c1Cl
Show InChI InChI=1S/C25H28Cl2N6O5/c1-4-19(34)29-15-11-38-12-16(15)30-24-28-8-14-10-32(25(35)33(23(14)31-24)9-13-5-6-13)22-20(26)17(36-2)7-18(37-3)21(22)27/h4,7-8,13,15-16H,1,5-6,9-12H2,2-3H3,(H,29,34)(H,28,30,31)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM100424
PNG
(US10189794, Compound I-217 | US10618902, Compound ...)
Show SMILES CCN1C(=O)N(Cc2cnc(NC3COCC3NC(=O)C=C)nc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C23H26Cl2N6O5/c1-5-17(32)27-13-10-36-11-14(13)28-22-26-8-12-9-31(23(33)30(6-2)21(12)29-22)20-18(24)15(34-3)7-16(35-4)19(20)25/h5,7-8,13-14H,1,6,9-11H2,2-4H3,(H,27,32)(H,26,28,29)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101058
PNG
(US10189794, Compound I-242 | US10618902, Compound ...)
Show SMILES COc1ccc(Nc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(C)c3n2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H23Cl2N5O5/c1-6-20(34)30-17-10-14(36-3)7-8-16(17)31-26-29-12-13-9-15(25(35)33(2)24(13)32-26)21-22(27)18(37-4)11-19(38-5)23(21)28/h6-12H,1H2,2-5H3,(H,30,34)(H,29,31,32)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438567
PNG
(US10618902, Compound I-248)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC3CN(CC3NC(=O)C=C)c3ccn(C)n3)nc2n(C)c1=O
Show InChI InChI=1S/C27H28Cl2N8O4/c1-6-21(38)31-16-12-37(20-7-8-35(2)34-20)13-17(16)32-27-30-11-14-9-15(26(39)36(3)25(14)33-27)22-23(28)18(40-4)10-19(41-5)24(22)29/h6-11,16-17H,1,12-13H2,2-5H3,(H,31,38)(H,30,32,33)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438577
PNG
(US10618902, Compound I-258)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3cc(ccc3NC(=O)C=C)C(F)(F)F)nc2n(C)c1=O
Show InChI InChI=1S/C26H20Cl2F3N5O4/c1-5-19(37)33-15-7-6-13(26(29,30)31)9-16(15)34-25-32-11-12-8-14(24(38)36(2)23(12)35-25)20-21(27)17(39-3)10-18(40-4)22(20)28/h5-11H,1H2,2-4H3,(H,33,37)(H,32,34,35)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438583
PNG
(US10618902, Compound I-264)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccc(cc3NC(=O)C=C)-c3cnn(C)c3)nc2n(C)c1=O
Show InChI InChI=1S/C29H25Cl2N7O4/c1-6-23(39)34-20-10-15(17-13-33-37(2)14-17)7-8-19(20)35-29-32-12-16-9-18(28(40)38(3)27(16)36-29)24-25(30)21(41-4)11-22(42-5)26(24)31/h6-14H,1H2,2-5H3,(H,34,39)(H,32,35,36)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438604
PNG
(US10618902, Compound I-285)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(F)c(F)ccc3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C25H19Cl2F2N5O4/c1-5-17(35)31-14-7-6-13(28)21(29)22(14)32-25-30-10-11-8-12(24(36)34(2)23(11)33-25)18-19(26)15(37-3)9-16(38-4)20(18)27/h5-10H,1H2,2-4H3,(H,31,35)(H,30,32,33)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438605
PNG
(US10618902, Compound I-286)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC3CC(=O)CC3NC(=O)C=C)nc2n(C)c1=O
Show InChI InChI=1S/C24H23Cl2N5O5/c1-5-18(33)28-14-7-12(32)8-15(14)29-24-27-10-11-6-13(23(34)31(2)22(11)30-24)19-20(25)16(35-3)9-17(36-4)21(19)26/h5-6,9-10,14-15H,1,7-8H2,2-4H3,(H,28,33)(H,27,29,30)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438611
PNG
(US10618902, Compound I-292)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3CN(C[C@@H]3NC(=O)C=C)c3cc[nH]n3)nc2n(C)c1=O
PDB

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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438620
PNG
(US10618902, Compound I-301)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)n(C[C@H]3CCN(C3)C(C)=O)c2nc1=O
Show InChI InChI=1S/C29H33ClN6O6/c1-5-25(38)32-22-14-42-15-23(22)33-29-31-11-18-8-21(20-9-19(40-3)10-24(41-4)26(20)30)28(39)34-27(18)36(29)13-17-6-7-35(12-17)16(2)37/h5,8-11,17,22-23H,1,6-7,12-15H2,2-4H3,(H,31,33)(H,32,38)/t17-,22-,23+/m0/s1
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438622
PNG
(US10618902, Compound I-303)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)n(CCO)c2nc1=O
Show InChI InChI=1S/C24H25Cl2N5O6/c1-4-18(33)28-14-10-37-11-15(14)29-24-27-9-12-7-13(23(34)30-22(12)31(24)5-6-32)19-20(25)16(35-2)8-17(36-3)21(19)26/h4,7-9,14-15,32H,1,5-6,10-11H2,2-3H3,(H,27,29)(H,28,33)/t14-,15+/m0/s1
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438626
PNG
(US10618902, Compound I-307)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C[C@@H]2CCN(C2)C(C)=O)c1=O
Show InChI InChI=1S/C29H32Cl2N6O6/c1-5-23(39)33-19-13-43-14-20(19)34-29-32-10-17-8-18(24-25(30)21(41-3)9-22(42-4)26(24)31)28(40)37(27(17)35-29)12-16-6-7-36(11-16)15(2)38/h5,8-10,16,19-20H,1,6-7,11-14H2,2-4H3,(H,33,39)(H,32,34,35)/t16-,19+,20-/m1/s1
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM438628
PNG
(US10618902, Compound I-309)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C(O)CO)c1=O
Show InChI InChI=1S/C24H25Cl2N5O7/c1-4-17(33)28-13-9-38-10-14(13)29-24-27-7-11-5-12(23(35)31(18(34)8-32)22(11)30-24)19-20(25)15(36-2)6-16(37-3)21(19)26/h4-7,13-14,18,32,34H,1,8-10H2,2-3H3,(H,28,33)(H,27,29,30)/t13-,14+,18?/m0/s1
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88560
PNG
(US10189794, Compound I-2 | US10618902, Compound I-...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5-11H,1,12H2,2-4H3,(H,28,33)(H,27,29,30)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88563
PNG
(US10189794, Compound I-5 | US10618902, Compound I-...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H24N6O4/c1-5-21(31)26-19-8-6-7-9-20(19)27-23-25-13-15-14-30(24(32)29(2)22(15)28-23)16-10-17(33-3)12-18(11-16)34-4/h5-13H,1,14H2,2-4H3,(H,26,31)(H,25,27,28)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88652
PNG
(US10189794, Compound I-15 | US10618902, Compound I...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H36N8O4/c1-6-27(39)32-26-16-21(37-12-10-36(7-2)11-13-37)8-9-25(26)33-29-31-18-20-19-38(30(40)35(3)28(20)34-29)22-14-23(41-4)17-24(15-22)42-5/h6,8-9,14-18H,1,7,10-13,19H2,2-5H3,(H,32,39)(H,31,33,34)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88665
PNG
(US10189794, Compound I-28 | US10618902, Compound I...)
Show SMILES COc1cccc(CN2C(=O)N(Cc3cnc(Nc4ccccc4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C31H28Cl2N6O5/c1-5-25(40)35-21-11-6-7-12-22(21)36-30-34-15-19-17-38(28-26(32)23(43-3)14-24(44-4)27(28)33)31(41)39(29(19)37-30)16-18-9-8-10-20(13-18)42-2/h5-15H,1,16-17H2,2-4H3,(H,35,40)(H,34,36,37)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88672
PNG
(US10189794, Compound I-35 | US10618902, Compound I...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3cccnc3)C2=O)c1Cl
Show InChI InChI=1S/C29H31Cl2N7O4/c1-4-23(39)34-19-9-5-6-10-20(19)35-28-33-14-18-16-37(26-24(30)21(41-2)12-22(42-3)25(26)31)29(40)38(27(18)36-28)15-17-8-7-11-32-13-17/h4,7-8,11-14,19-20H,1,5-6,9-10,15-16H2,2-3H3,(H,34,39)(H,33,35,36)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88690
PNG
(US10189794, Compound I-47 | US10618902, Compound I...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CC#N)C2=O)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-4-19(35)30-15-7-5-6-8-16(15)31-24-29-12-14-13-34(25(36)33(10-9-28)23(14)32-24)22-20(26)17(37-2)11-18(38-3)21(22)27/h4,11-12,15-16H,1,5-8,10,13H2,2-3H3,(H,30,35)(H,29,31,32)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM89509
PNG
(US10189794, Compound I-49 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(C)ccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C25H26N6O4/c1-6-22(32)27-20-8-7-15(2)9-21(20)28-24-26-13-16-14-31(25(33)30(3)23(16)29-24)17-10-18(34-4)12-19(11-17)35-5/h6-13H,1,14H2,2-5H3,(H,27,32)(H,26,28,29)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91652
PNG
(US10189794, Compound I-58 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCC(O)CO)C1=O
Show InChI InChI=1S/C27H30N6O6/c1-4-24(36)29-22-7-5-6-8-23(22)30-26-28-14-17-15-33(18-11-20(38-2)13-21(12-18)39-3)27(37)32(25(17)31-26)10-9-19(35)16-34/h4-8,11-14,19,34-35H,1,9-10,15-16H2,2-3H3,(H,29,36)(H,28,30,31)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91653
PNG
(US10189794, Compound I-59 | US10618902, Compound I...)
Show SMILES COCCN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H28N6O5/c1-5-23(33)28-21-8-6-7-9-22(21)29-25-27-15-17-16-32(18-12-19(36-3)14-20(13-18)37-4)26(34)31(10-11-35-2)24(17)30-25/h5-9,12-15H,1,10-11,16H2,2-4H3,(H,28,33)(H,27,29,30)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91680
PNG
(US10189794, Compound I-60 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CCN(CC2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C34H41N7O6/c1-7-29(42)36-27-10-8-9-11-28(27)37-31-35-19-23-21-40(24-16-25(45-5)18-26(17-24)46-6)32(43)41(30(23)38-31)20-22-12-14-39(15-13-22)33(44)47-34(2,3)4/h7-11,16-19,22H,1,12-15,20-21H2,2-6H3,(H,36,42)(H,35,37,38)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91858
PNG
(US10189794, Compound I-63 | US10618902, Compound I...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H32Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h4-7,10-11,14-15,20-21H,1,8-9,12-13,16-17H2,2-3H3,(H,34,39)(H,33,35,36)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91862
PNG
(US10189794, Compound I-64 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2cscn2)C1=O
Show InChI InChI=1S/C27H25N7O4S/c1-4-24(35)30-22-7-5-6-8-23(22)31-26-28-12-17-13-33(19-9-20(37-2)11-21(10-19)38-3)27(36)34(25(17)32-26)14-18-15-39-16-29-18/h4-12,15-16H,1,13-14H2,2-3H3,(H,30,35)(H,28,31,32)
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Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM323860
PNG
(US10189794, Compound I-65 | US10618902, Compound I...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Oc4ccccc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H21Cl2N5O5/c1-5-18(32)28-14-8-6-7-9-15(14)36-23-27-11-13-12-31(24(33)30(2)22(13)29-23)21-19(25)16(34-3)10-17(35-4)20(21)26/h5-11H,1,12H2,2-4H3,(H,28,32)
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n/an/a<500n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91868
PNG
(US10189794, Compound I-67 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NS(=O)(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C23H24N6O5S/c1-5-35(31,32)27-20-9-7-6-8-19(20)25-22-24-13-15-14-29(23(30)28(2)21(15)26-22)16-10-17(33-3)12-18(11-16)34-4/h5-13,27H,1,14H2,2-4H3,(H,24,25,26)
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n/an/a<500n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92748
PNG
(US10189794, Compound I-92 | US10618902, Compound I...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(N[C@@H]4CCCC[C@@H]4NC(=O)C=C)nc3N(Cc3nccs3)C2=O)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O4S/c1-4-20(37)32-16-7-5-6-8-17(16)33-26-31-12-15-13-35(24-22(28)18(39-2)11-19(40-3)23(24)29)27(38)36(25(15)34-26)14-21-30-9-10-41-21/h4,9-12,16-17H,1,5-8,13-14H2,2-3H3,(H,32,37)(H,31,33,34)/t16-,17+/m0/s1
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n/an/a<500n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM101110
PNG
(US10189794, Compound I-99 | US10618902, Compound I...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC(F)F)C1=O
Show InChI InChI=1S/C25H24F2N6O4/c1-4-22(34)29-19-7-5-6-8-20(19)30-24-28-12-15-13-32(16-9-17(36-2)11-18(10-16)37-3)25(35)33(14-21(26)27)23(15)31-24/h4-12,21H,1,13-14H2,2-3H3,(H,29,34)(H,28,30,31)
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n/an/a<500n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM323967
PNG
(US10189794, Compound I-214 | US10618902, Compound ...)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(Cc3cn[nH]c3)C2=O)c1Cl
PDB

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n/an/a<500n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
A 10 stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...


US Patent US10618902 (2020)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 256 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%