BindingDB logo
myBDB logout

Patent code US10632126

Compile Data Set for Download or QSAR

Found 676 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262050
PNG
(US10251892, Example 168 | US10632126, Example 168 ...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cn(CC)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C23H25F2N5O3/c1-6-28-12-15(13(3)27-28)16-8-17-14(10-26-16)11-30(23(31)29(17)7-2)22-20(24)18(32-4)9-19(33-5)21(22)25/h8-10,12H,6-7,11H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262051
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-1-ethyl-7-(1...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cnn(C)c1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H21F2N5O3/c1-5-27-15-6-14(12-9-25-26(2)10-12)24-8-13(15)11-28(21(27)29)20-18(22)16(30-3)7-17(31-4)19(20)23/h6-10H,5,11H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262052
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H23F2N5O3/c1-6-28-16-7-15(14-11-27(3)26-12(14)2)25-9-13(16)10-29(22(28)30)21-19(23)17(31-4)8-18(32-5)20(21)24/h7-9,11H,6,10H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262059
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(=O)NCCO)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H25F2N5O5/c1-4-31-18-9-17(14-5-6-16(29-11-14)24(34)28-7-8-33)30-12-15(18)13-32(25(31)35)23-21(26)19(36-2)10-20(37-3)22(23)27/h5-6,9-12,33H,4,7-8,13H2,1-3H3,(H,28,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262060
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(=O)NC(C)C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-6-32-19-9-18(15-7-8-17(29-11-15)25(34)31-14(2)3)30-12-16(19)13-33(26(32)35)24-22(27)20(36-4)10-21(37-5)23(24)28/h7-12,14H,6,13H2,1-5H3,(H,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262067
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccncc2)c1F
Show InChI InChI=1S/C23H19F2N3O3/c1-30-17-10-18(31-2)20(25)21(19(17)24)28-12-14-11-27-16(13-3-7-26-8-4-13)9-15(14)23(5-6-23)22(28)29/h3-4,7-11H,5-6,12H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262068
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(C)c2)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-27-10-13(9-26-27)15-6-14-12(8-25-15)11-28(21(29)22(14)4-5-22)20-18(23)16(30-2)7-17(31-3)19(20)24/h6-10H,4-5,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262069
PNG
(1-(5-{3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(5-m...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3nnc(C)o3)C2=O)-c2ccc(nc2)C2(CCC2)C#N)c1F
Show InChI InChI=1S/C29H25F2N7O4/c1-16-35-36-24(42-16)14-37-20-9-19(17-5-6-23(34-11-17)29(15-32)7-4-8-29)33-12-18(20)13-38(28(37)39)27-25(30)21(40-2)10-22(41-3)26(27)31/h5-6,9-12H,4,7-8,13-14H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261910
PNG
(6′-(5-(1H-imidazol-1-yl)pyridin-3-yl)-2̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(c2)-n2ccnc2)c1F
Show InChI InChI=1S/C26H21F2N5O3/c1-35-20-9-21(36-2)23(28)24(22(20)27)33-13-16-11-31-19(8-18(16)26(3-4-26)25(33)34)15-7-17(12-30-10-15)32-6-5-29-14-32/h5-12,14H,3-4,13H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261921
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-7-(py...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cccnc1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-4-27-16-8-15(13-6-5-7-25-10-13)26-11-14(16)12-28(22(27)29)21-19(23)17(30-2)9-18(31-3)20(21)24/h5-11H,4,12H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261929
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cc(C)on3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O4/c1-13-6-16(30-37-13)11-32-19-7-18(17-12-31(3)29-14(17)2)28-9-15(19)10-33(25(32)34)24-22(26)20(35-4)8-21(36-5)23(24)27/h6-9,12H,10-11H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261931
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C3CCOC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C24H25F2N5O4/c1-13-16(11-29(2)28-13)17-7-18-14(9-27-17)10-30(24(32)31(18)15-5-6-35-12-15)23-21(25)19(33-3)8-20(34-4)22(23)26/h7-9,11,15H,5-6,10,12H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261933
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cc(C)no3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O4/c1-13-6-16(37-30-13)11-32-19-7-18(17-12-31(3)29-14(17)2)28-9-15(19)10-33(25(32)34)24-22(26)20(35-4)8-21(36-5)23(24)27/h6-9,12H,10-11H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261943
PNG
(4-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cc2)C#N)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H22F2N6O3/c1-15-19(14-33(2)32-15)20-9-21-17(12-31-20)13-34(26-24(28)22(37-3)10-23(38-4)25(26)29)27(36)35(21)18-7-5-16(11-30)6-8-18/h5-10,12,14H,13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261947
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cnn(C)c3C)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H27F2N7O3/c1-14-18(13-32(3)31-14)19-7-20-17(9-29-19)12-35(25-23(27)21(37-5)8-22(38-6)24(25)28)26(36)34(20)11-16-10-30-33(4)15(16)2/h7-10,13H,11-12H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261955
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2)C2CN(C2)S(C)(=O)=O)c1F
Show InChI InChI=1S/C25H25F2N5O5S/c1-36-19-7-20(37-2)22(27)23(21(19)26)31-10-14-8-28-18(6-17(14)25(4-5-25)24(31)33)15-9-29-32(11-15)16-12-30(13-16)38(3,34)35/h6-9,11,16H,4-5,10,12-13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261967
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES CCc1nnc(CN2C(=O)N(Cc3cnc(cc23)-c2cn(C)nc2C)c2c(F)c(OC)cc(OC)c2F)o1
Show InChI InChI=1S/C25H25F2N7O4/c1-6-20-29-30-21(38-20)12-33-17-7-16(15-11-32(3)31-13(15)2)28-9-14(17)10-34(25(33)35)24-22(26)18(36-4)8-19(37-5)23(24)27/h7-9,11H,6,10,12H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261968
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccnc(C)c3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H26F2N6O3/c1-15-8-17(6-7-30-15)12-34-21-9-20(19-14-33(3)32-16(19)2)31-11-18(21)13-35(27(34)36)26-24(28)22(37-4)10-23(38-5)25(26)29/h6-11,14H,12-13H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261992
PNG
(1-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)C2(CC2)C#N)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C24H22F2N6O3/c1-13-15(11-30(2)29-13)16-7-17-14(9-28-16)10-31(23(33)32(17)24(12-27)5-6-24)22-20(25)18(34-3)8-19(35-4)21(22)26/h7-9,11H,5-6,10H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262014
PNG
(4-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cc2)C(=O)N(C)C)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C29H28F2N6O4/c1-16-20(15-35(4)33-16)21-11-22-18(13-32-21)14-36(27-25(30)23(40-5)12-24(41-6)26(27)31)29(39)37(22)19-9-7-17(8-10-19)28(38)34(2)3/h7-13,15H,14H2,1-6H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262016
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cc2)-c2nnc(C)o2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C29H25F2N7O4/c1-15-20(14-36(3)35-15)21-10-22-18(12-32-21)13-37(27-25(30)23(40-4)11-24(41-5)26(27)31)29(39)38(22)19-8-6-17(7-9-19)28-34-33-16(2)42-28/h6-12,14H,13H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262018
PNG
(Methyl 4-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(...)
Show SMILES COC(=O)Nc1ccc(cc1)N1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C28H26F2N6O5/c1-15-19(14-34(2)33-15)20-10-21-16(12-31-20)13-35(26-24(29)22(39-3)11-23(40-4)25(26)30)28(38)36(21)18-8-6-17(7-9-18)32-27(37)41-5/h6-12,14H,13H2,1-5H3,(H,32,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262021
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(c3cn[nH]c3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C23H21F2N7O3/c1-12-15(11-30(2)29-12)16-5-17-13(7-26-16)10-31(23(33)32(17)14-8-27-28-9-14)22-20(24)18(34-3)6-19(35-4)21(22)25/h5-9,11H,10H2,1-4H3,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262026
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc3[nH]ncc3c2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H23F2N7O3/c1-14-18(13-34(2)33-14)20-8-21-16(10-30-20)12-35(26-24(28)22(38-3)9-23(39-4)25(26)29)27(37)36(21)17-5-6-19-15(7-17)11-31-32-19/h5-11,13H,12H2,1-4H3,(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262026
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc3[nH]ncc3c2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H23F2N7O3/c1-14-18(13-34(2)33-14)20-8-21-16(10-30-20)12-35(26-24(28)22(38-3)9-23(39-4)25(26)29)27(37)36(21)17-5-6-19-15(7-17)11-31-32-19/h5-11,13H,12H2,1-4H3,(H,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262029
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(1-(1- (...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2)C2CCN(C2)S(C)(=O)=O)c1F
Show InChI InChI=1S/C26H27F2N5O5S/c1-37-20-9-21(38-2)23(28)24(22(20)27)32-12-15-10-29-19(8-18(15)26(5-6-26)25(32)34)16-11-30-33(13-16)17-4-7-31(14-17)39(3,35)36/h8-11,13,17H,4-7,12,14H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM262032
PNG
(6'-(1-(1-acetylpyrrolidin-3-yl)- 1H-pyrazol-4-yl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2)C2CCN(C2)C(C)=O)c1F
Show InChI InChI=1S/C27H27F2N5O4/c1-15(35)32-7-4-18(14-32)34-13-17(11-31-34)20-8-19-16(10-30-20)12-33(26(36)27(19)5-6-27)25-23(28)21(37-2)9-22(38-3)24(25)29/h8-11,13,18H,4-7,12,14H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262032
PNG
(6'-(1-(1-acetylpyrrolidin-3-yl)- 1H-pyrazol-4-yl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2)C2CCN(C2)C(C)=O)c1F
Show InChI InChI=1S/C27H27F2N5O4/c1-15(35)32-7-4-18(14-32)34-13-17(11-31-34)20-8-19-16(10-30-20)12-33(26(36)27(19)5-6-27)25-23(28)21(37-2)9-22(38-3)24(25)29/h8-11,13,18H,4-7,12,14H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262039
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(1-(2- m...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(CCN3CCOCC3)c2)c1F
Show InChI InChI=1S/C27H29F2N5O4/c1-36-21-12-22(37-2)24(29)25(23(21)28)34-16-17-13-30-20(11-19(17)27(3-4-27)26(34)35)18-14-31-33(15-18)6-5-32-7-9-38-10-8-32/h11-15H,3-10,16H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262049
PNG
(6'-(1-((1-acetylazetidin-3- yl)methyl)-1H-pyrazol-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(CC3CN(C3)C(C)=O)c2)c1F
Show InChI InChI=1S/C27H27F2N5O4/c1-15(35)32-10-16(11-32)12-33-13-18(9-31-33)20-6-19-17(8-30-20)14-34(26(36)27(19)4-5-27)25-23(28)21(37-2)7-22(38-3)24(25)29/h6-9,13,16H,4-5,10-12,14H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262065
PNG
(1-(4-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(cc1)C1(CC1)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H24F2N4O3/c1-4-32-20-11-19(16-5-7-18(8-6-16)27(15-30)9-10-27)31-13-17(20)14-33(26(32)34)25-23(28)21(35-2)12-22(36-3)24(25)29/h5-8,11-13H,4,9-10,14H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262069
PNG
(1-(5-{3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(5-m...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3nnc(C)o3)C2=O)-c2ccc(nc2)C2(CCC2)C#N)c1F
Show InChI InChI=1S/C29H25F2N7O4/c1-16-35-36-24(42-16)14-37-20-9-19(17-5-6-23(34-11-17)29(15-32)7-4-8-29)33-12-18(20)13-38(28(37)39)27-25(30)21(40-2)10-22(41-3)26(27)31/h5-6,9-12H,4,7-8,13-14H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261898
PNG
(6′-(5-aminopyridin-3-yl)-2′-(2,6-diflu...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(N)c2)c1F
Show InChI InChI=1S/C23H20F2N4O3/c1-31-17-7-18(32-2)20(25)21(19(17)24)29-11-13-9-28-16(12-5-14(26)10-27-8-12)6-15(13)23(3-4-23)22(29)30/h5-10H,3-4,11,26H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261899
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(F)c2)c1F
Show InChI InChI=1S/C23H18F3N3O3/c1-31-17-7-18(32-2)20(26)21(19(17)25)29-11-13-9-28-16(12-5-14(24)10-27-8-12)6-15(13)23(3-4-23)22(29)30/h5-10H,3-4,11H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261900
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(c2)N2CCOCC2)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-35-21-11-22(36-2)24(29)25(23(21)28)33-15-17-13-31-20(10-19(17)27(3-4-27)26(33)34)16-9-18(14-30-12-16)32-5-7-37-8-6-32/h9-14H,3-8,15H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261925
PNG
(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C1(CCC1)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H25F2N5O3/c1-4-33-19-10-18(16-6-7-22(32-12-16)27(15-30)8-5-9-27)31-13-17(19)14-34(26(33)35)25-23(28)20(36-2)11-21(37-3)24(25)29/h6-7,10-13H,4-5,8-9,14H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261934
PNG
(1-((5-cyclopropylisoxazol-3-yl)methyl)-3-(2,6-difl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cc(on3)C3CC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H26F2N6O4/c1-14-18(13-33(2)31-14)19-8-20-16(10-30-19)11-35(26-24(28)22(37-3)9-23(38-4)25(26)29)27(36)34(20)12-17-7-21(39-32-17)15-5-6-15/h7-10,13,15H,5-6,11-12H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261967
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES CCc1nnc(CN2C(=O)N(Cc3cnc(cc23)-c2cn(C)nc2C)c2c(F)c(OC)cc(OC)c2F)o1
Show InChI InChI=1S/C25H25F2N7O4/c1-6-20-29-30-21(38-20)12-33-17-7-16(15-11-32(3)31-13(15)2)28-9-14(17)10-34(25(33)35)24-22(26)18(36-4)8-19(37-5)23(24)27/h7-9,11H,6,10,12H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261983
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ncc(C)o3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O4/c1-13-8-29-21(37-13)12-32-18-6-17(16-11-31(3)30-14(16)2)28-9-15(18)10-33(25(32)34)24-22(26)19(35-4)7-20(36-5)23(24)27/h6-9,11H,10,12H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261995
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccccn3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H24F2N6O3/c1-15-18(14-32(2)31-15)19-9-20-16(11-30-19)12-34(26(35)33(20)13-17-7-5-6-8-29-17)25-23(27)21(36-3)10-22(37-4)24(25)28/h5-11,14H,12-13H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261995
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccccn3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H24F2N6O3/c1-15-18(14-32(2)31-15)19-9-20-16(11-30-19)12-34(26(35)33(20)13-17-7-5-6-8-29-17)25-23(27)21(36-3)10-22(37-4)24(25)28/h5-11,14H,12-13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261996
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3csc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O3S/c1-13-17(11-31(3)30-13)18-6-19-15(8-28-18)9-33(25(34)32(19)10-16-12-37-14(2)29-16)24-22(26)20(35-4)7-21(36-5)23(24)27/h6-8,11-12H,9-10H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261998
PNG
(2-(4-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(CC#N)cc2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C28H24F2N6O3/c1-16-20(15-34(2)33-16)21-11-22-18(13-32-21)14-35(27-25(29)23(38-3)12-24(39-4)26(27)30)28(37)36(22)19-7-5-17(6-8-19)9-10-31/h5-8,11-13,15H,9,14H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261998
PNG
(2-(4-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(CC#N)cc2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C28H24F2N6O3/c1-16-20(15-34(2)33-16)21-11-22-18(13-32-21)14-35(27-25(29)23(38-3)12-24(39-4)26(27)30)28(37)36(22)19-7-5-17(6-8-19)9-10-31/h5-8,11-13,15H,9,14H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262000
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2cccc(F)c2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H22F3N5O3/c1-14-18(13-32(2)31-14)19-9-20-15(11-30-19)12-33(26(35)34(20)17-7-5-6-16(27)8-17)25-23(28)21(36-3)10-22(37-4)24(25)29/h5-11,13H,12H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262032
PNG
(6'-(1-(1-acetylpyrrolidin-3-yl)- 1H-pyrazol-4-yl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2)C2CCN(C2)C(C)=O)c1F
Show InChI InChI=1S/C27H27F2N5O4/c1-15(35)32-7-4-18(14-32)34-13-17(11-31-34)20-8-19-16(10-30-20)12-33(26(36)27(19)5-6-27)25-23(28)21(37-2)9-22(38-3)24(25)29/h8-11,13,18H,4-7,12,14H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262034
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(1-(2-(4...)
Show SMILES COC1CCN(CCn2cc(cn2)-c2cc3c(CN(C(=O)C33CC3)c3c(F)c(OC)cc(OC)c3F)cn2)CC1
Show InChI InChI=1S/C29H33F2N5O4/c1-38-20-4-8-34(9-5-20)10-11-35-16-19(15-33-35)22-12-21-18(14-32-22)17-36(28(37)29(21)6-7-29)27-25(30)23(39-2)13-24(40-3)26(27)31/h12-16,20H,4-11,17H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262035
PNG
(2-(4-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(CC#N)nc2C)c1F
Show InChI InChI=1S/C24H21F2N5O3/c1-13-15(12-30(29-13)7-6-27)17-8-16-14(10-28-17)11-31(23(32)24(16)4-5-24)22-20(25)18(33-2)9-19(34-3)21(22)26/h8-10,12H,4-5,7,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262044
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-{1-[(1,1...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(CC3CCCS(=O)(=O)N3)c2)c1F
Show InChI InChI=1S/C26H27F2N5O5S/c1-37-20-9-21(38-2)23(28)24(22(20)27)33-13-15-10-29-19(8-18(15)26(5-6-26)25(33)34)16-11-30-32(12-16)14-17-4-3-7-39(35,36)31-17/h8-12,17,31H,3-7,13-14H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261980
PNG
(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cn2)C#N)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H21F2N7O3/c1-14-17(13-33(2)32-14)18-7-19-16(11-30-18)12-34(25-23(27)20(37-3)8-21(38-4)24(25)28)26(36)35(19)22-6-5-15(9-29)10-31-22/h5-8,10-11,13H,12H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10632126 (2020)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 676 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%