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Patent code US10633389

Compile Data Set for Download or QSAR

Found 1029 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440031
PNG
(US10633389, Example 368-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(N[C@@H]2CCOC2)c(C)c(n1)N1CC[C@@H](C1)N(C)C
Show InChI InChI=1S/C25H38N6O3/c1-17-23(27-19-9-11-33-15-19)28-24(29-25(17)31-10-8-20(14-31)30(3)4)18-6-5-7-22(12-18)34-16-21(32)13-26-2/h5-7,12,19-21,26,32H,8-11,13-16H2,1-4H3,(H,27,28,29)/t19-,20+,21?/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440032
PNG
(US10633389, Example 369-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(N[C@@H]2CCOC2)c(C)c(n1)N1CC[C@H](C1)OC
Show InChI InChI=1S/C24H35N5O4/c1-16-22(26-18-8-10-32-14-18)27-23(28-24(16)29-9-7-21(13-29)31-3)17-5-4-6-20(11-17)33-15-19(30)12-25-2/h4-6,11,18-19,21,25,30H,7-10,12-15H2,1-3H3,(H,26,27,28)/t18-,19?,21-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440033
PNG
(US10633389, Example 370-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(N[C@@H]2CCOC2)c(C)c(n1)N1CCC(CC1)OC
Show InChI InChI=1S/C25H37N5O4/c1-17-23(27-19-9-12-33-15-19)28-24(29-25(17)30-10-7-21(32-3)8-11-30)18-5-4-6-22(13-18)34-16-20(31)14-26-2/h4-6,13,19-21,26,31H,7-12,14-16H2,1-3H3,(H,27,28,29)/t19-,20?/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440073
PNG
(US10633389, Example 412-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(N[C@@H]2CCOC2)c(C)c(n1)N1CC2CCC(C1)O2
Show InChI InChI=1S/C25H35N5O4/c1-16-23(27-18-8-9-32-14-18)28-24(29-25(16)30-12-21-6-7-22(13-30)34-21)17-4-3-5-20(10-17)33-15-19(31)11-26-2/h3-5,10,18-19,21-22,26,31H,6-9,11-15H2,1-2H3,(H,27,28,29)/t18-,19?,21?,22?/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440089
PNG
(US10633389, Example 429-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(N[C@@H]2CCOC2)c(C)c(n1)N1CCC2(CCNCC2)CC1
Show InChI InChI=1S/C28H42N6O3/c1-20-25(31-22-6-15-36-18-22)32-26(21-4-3-5-24(16-21)37-19-23(35)17-29-2)33-27(20)34-13-9-28(10-14-34)7-11-30-12-8-28/h3-5,16,22-23,29-30,35H,6-15,17-19H2,1-2H3,(H,31,32,33)/t22-,23?/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440095
PNG
(US10633389, Example 435-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(N[C@@H]2CCOC2)c(C)c(n1)N1CCN(C)C(=O)C1
Show InChI InChI=1S/C24H34N6O4/c1-16-22(26-18-7-10-33-14-18)27-23(28-24(16)30-9-8-29(3)21(32)13-30)17-5-4-6-20(11-17)34-15-19(31)12-25-2/h4-6,11,18-19,25,31H,7-10,12-15H2,1-3H3,(H,26,27,28)/t18-,19?/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440102
PNG
(US10633389, Example 442-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(NC2CCOC2)c(C)c(n1)N1CC(N)CC(Cl)C1
Show InChI InChI=1S/C24H35ClN6O3/c1-15-22(28-19-6-7-33-13-19)29-23(30-24(15)31-11-17(25)9-18(26)12-31)16-4-3-5-21(8-16)34-14-20(32)10-27-2/h3-5,8,17-20,27,32H,6-7,9-14,26H2,1-2H3,(H,28,29,30)
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440107
PNG
(US10633389, Example 448-1a)
Show SMILES CCS(=O)(=O)N1CCN(CC1(C)C)c1nc(nc(NC2CCOC2)c1C)-c1cccc(OCC(O)CNC)c1
Show InChI InChI=1S/C27H42N6O5S/c1-6-39(35,36)33-12-11-32(18-27(33,3)4)26-19(2)24(29-21-10-13-37-16-21)30-25(31-26)20-8-7-9-23(14-20)38-17-22(34)15-28-5/h7-9,14,21-22,28,34H,6,10-13,15-18H2,1-5H3,(H,29,30,31)
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440127
PNG
(US10633389, Example 468-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(N[C@@H]2CCOC2)c(C)c(n1)N1CCC(C1)n1nc(C)cc1C
Show InChI InChI=1S/C28H39N7O3/c1-18-12-19(2)35(33-18)23-8-10-34(15-23)28-20(3)26(30-22-9-11-37-16-22)31-27(32-28)21-6-5-7-25(13-21)38-17-24(36)14-29-4/h5-7,12-13,22-24,29,36H,8-11,14-17H2,1-4H3,(H,30,31,32)/t22-,23?,24?/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440154
PNG
(US10633389, Example 503-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(cc(n1)-c1ccnc(c1)C(C)(C)O)N(C)C1CCOCC1
Show InChI InChI=1S/C28H37N5O4/c1-28(2,35)25-15-19(8-11-30-25)24-16-26(33(4)21-9-12-36-13-10-21)32-27(31-24)20-6-5-7-23(14-20)37-18-22(34)17-29-3/h5-8,11,14-16,21-22,29,34-35H,9-10,12-13,17-18H2,1-4H3
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440155
PNG
(US10633389, Example 504-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(cc(n1)-c1c[nH]c2ncncc12)N(C)C1CCOCC1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440167
PNG
(US10633389, Example 516-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(cc(n1)-c1cnn(CC(C)C)c1)N(C)C1CCOCC1
Show InChI InChI=1S/C27H38N6O3/c1-19(2)16-33-17-21(14-29-33)25-13-26(32(4)22-8-10-35-11-9-22)31-27(30-25)20-6-5-7-24(12-20)36-18-23(34)15-28-3/h5-7,12-14,17,19,22-23,28,34H,8-11,15-16,18H2,1-4H3
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440182
PNG
(US10633389, Example 531-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(cc(n1)N1CCN(C)CC1)N(C)C1CCOCC1
Show InChI InChI=1S/C25H38N6O3/c1-26-17-21(32)18-34-22-6-4-5-19(15-22)25-27-23(30(3)20-7-13-33-14-8-20)16-24(28-25)31-11-9-29(2)10-12-31/h4-6,15-16,20-21,26,32H,7-14,17-18H2,1-3H3
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440192
PNG
(US10633389, Example 541-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(cc(n1)-c1ccnc(OC)c1)N(C)C1CCOCC1
Show InChI InChI=1S/C26H33N5O4/c1-27-16-21(32)17-35-22-6-4-5-19(13-22)26-29-23(18-7-10-28-25(14-18)33-3)15-24(30-26)31(2)20-8-11-34-12-9-20/h4-7,10,13-15,20-21,27,32H,8-9,11-12,16-17H2,1-3H3
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440200
PNG
(US10633389, Example 549-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(cc(n1)N1CCN(C)C(=O)C1)N(C)C1CCOCC1
Show InChI InChI=1S/C25H36N6O4/c1-26-15-20(32)17-35-21-6-4-5-18(13-21)25-27-22(30(3)19-7-11-34-12-8-19)14-23(28-25)31-10-9-29(2)24(33)16-31/h4-6,13-14,19-20,26,32H,7-12,15-17H2,1-3H3
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440220
PNG
(US10633389, Example 570-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(cc(n1)-c1cc2ccccc2o1)N(C)C1CCOCC1
Show InChI InChI=1S/C28H32N4O4/c1-29-17-22(33)18-35-23-8-5-7-20(14-23)28-30-24(26-15-19-6-3-4-9-25(19)36-26)16-27(31-28)32(2)21-10-12-34-13-11-21/h3-9,14-16,21-22,29,33H,10-13,17-18H2,1-2H3
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440272
PNG
(US10633389, Example 622-1a)
Show SMILES CNCC(O)COc1cccc(c1)-c1nc(cc(n1)-c1cccc(c1)C#N)N(C)C1CCOCC1
Show InChI InChI=1S/C27H31N5O3/c1-29-17-23(33)18-35-24-8-4-7-21(14-24)27-30-25(20-6-3-5-19(13-20)16-28)15-26(31-27)32(2)22-9-11-34-12-10-22/h3-8,13-15,22-23,29,33H,9-12,17-18H2,1-2H3
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440330
PNG
(US10633389, Example 682-1a)
Show SMILES CCN(CC)c1nc(nc(N2CCOCC2)c1C)-c1cccc(OCC(O)CNC)c1
Show InChI InChI=1S/C23H35N5O3/c1-5-27(6-2)22-17(3)23(28-10-12-30-13-11-28)26-21(25-22)18-8-7-9-20(14-18)31-16-19(29)15-24-4/h7-9,14,19,24,29H,5-6,10-13,15-16H2,1-4H3
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440359
PNG
(US10633389, Example 24-3)
Show SMILES CCOC(=O)N1CCOC[C@H]1CNc1nc(nc(-c2c(C)noc2C)c1C)-c1cc(OC[C@@H](O)CNC)ccc1Cl
Show InChI InChI=1S/C28H37ClN6O6/c1-6-39-28(37)35-9-10-38-14-19(35)12-31-26-16(2)25(24-17(3)34-41-18(24)4)32-27(33-26)22-11-21(7-8-23(22)29)40-15-20(36)13-30-5/h7-8,11,19-20,30,36H,6,9-10,12-15H2,1-5H3,(H,31,32,33)/t19-,20+/m1/s1
PDB

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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440363
PNG
(US10633389, Example 28-3)
Show SMILES CCOC(=O)N1CCCCC1CNc1nc(nc(-c2c(C)noc2C)c1C)-c1cc(OC[C@H](O)CNC)ccc1Cl
Show InChI InChI=1S/C29H39ClN6O5/c1-6-39-29(38)36-12-8-7-9-20(36)14-32-27-17(2)26(25-18(3)35-41-19(25)4)33-28(34-27)23-13-22(10-11-24(23)30)40-16-21(37)15-31-5/h10-11,13,20-21,31,37H,6-9,12,14-16H2,1-5H3,(H,32,33,34)/t20?,21-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440364
PNG
(US10633389, Example 29-3)
Show SMILES CNCC(O)COc1ccc(Cl)c(c1)-c1nc(NC2CCOCC2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C25H32ClN5O4/c1-14-23(22-15(2)31-35-16(22)3)29-25(30-24(14)28-17-7-9-33-10-8-17)20-11-19(5-6-21(20)26)34-13-18(32)12-27-4/h5-6,11,17-18,27,32H,7-10,12-13H2,1-4H3,(H,28,29,30)
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440381
PNG
(US10633389, Example 46-3)
Show SMILES CNCC(O)COc1ccc(Cl)c(c1)-c1nc(NC2CC(C)N(C(C)C2)C(=O)OC)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C29H39ClN6O5/c1-15-10-20(11-16(2)36(15)29(38)39-7)32-27-17(3)26(25-18(4)35-41-19(25)5)33-28(34-27)23-12-22(8-9-24(23)30)40-14-21(37)13-31-6/h8-9,12,15-16,20-21,31,37H,10-11,13-14H2,1-7H3,(H,32,33,34)
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440383
PNG
(US10633389, Example 48-3)
Show SMILES CCN1CCC[C@H]1CNc1nc(nc(-c2c(C)noc2C)c1C)-c1cc(OC[C@@H](O)CNC)ccc1Cl
Show InChI InChI=1S/C27H37ClN6O3/c1-6-34-11-7-8-19(34)13-30-26-16(2)25(24-17(3)33-37-18(24)4)31-27(32-26)22-12-21(9-10-23(22)28)36-15-20(35)14-29-5/h9-10,12,19-20,29,35H,6-8,11,13-15H2,1-5H3,(H,30,31,32)/t19-,20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440390
PNG
(US10633389, Example 55-3)
Show SMILES CNC[C@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CC3(C2)CCN(CC3)C2CC2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C30H39ClN6O3/c1-18-27(26-19(2)35-40-20(26)3)33-28(24-13-23(7-8-25(24)31)39-15-22(38)14-32-4)34-29(18)37-16-30(17-37)9-11-36(12-10-30)21-5-6-21/h7-8,13,21-22,32,38H,5-6,9-12,14-17H2,1-4H3/t22-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440391
PNG
(US10633389, Example 56-3)
Show SMILES CCOC(=O)N1CCOC[C@@H]1CNc1nc(nc(-c2c(C)noc2C)c1Cl)-c1cc(OC[C@H](O)CNC)ccc1Cl
Show InChI InChI=1S/C27H34Cl2N6O6/c1-5-39-27(37)35-8-9-38-13-17(35)11-31-26-23(29)24(22-15(2)34-41-16(22)3)32-25(33-26)20-10-19(6-7-21(20)28)40-14-18(36)12-30-4/h6-7,10,17-18,30,36H,5,8-9,11-14H2,1-4H3,(H,31,32,33)/t17-,18+/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440395
PNG
(US10633389, Example 60-3)
Show SMILES CCOC(=O)N1CCOC[C@H]1CNc1nc(nc(-c2c(C)noc2C)c1C)-c1cc(OC[C@H](O)CNC)ccc1F
Show InChI InChI=1S/C28H37FN6O6/c1-6-39-28(37)35-9-10-38-14-19(35)12-31-26-16(2)25(24-17(3)34-41-18(24)4)32-27(33-26)22-11-21(7-8-23(22)29)40-15-20(36)13-30-5/h7-8,11,19-20,30,36H,6,9-10,12-15H2,1-5H3,(H,31,32,33)/t19-,20-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440396
PNG
(US10633389, Example 61-3)
Show SMILES CCOC(=O)N1CCOC[C@@H]1CNc1nc(nc(-c2c(C)noc2C)c1C)-c1cc(OC[C@@H](O)CNC)ccc1F
Show InChI InChI=1S/C28H37FN6O6/c1-6-39-28(37)35-9-10-38-14-19(35)12-31-26-16(2)25(24-17(3)34-41-18(24)4)32-27(33-26)22-11-21(7-8-23(22)29)40-15-20(36)13-30-5/h7-8,11,19-20,30,36H,6,9-10,12-15H2,1-5H3,(H,31,32,33)/t19-,20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440399
PNG
(US10633389, Example 64-3)
Show SMILES CNC[C@@H](O)COc1ccc(F)c(c1)-c1nc(N[C@H]2CCN(C[C@H]2F)C(=O)OC)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C27H34F2N6O5/c1-14-24(23-15(2)34-40-16(23)3)32-26(19-10-18(6-7-20(19)28)39-13-17(36)11-30-4)33-25(14)31-22-8-9-35(12-21(22)29)27(37)38-5/h6-7,10,17,21-22,30,36H,8-9,11-13H2,1-5H3,(H,31,32,33)/t17-,21-,22+/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440400
PNG
(US10633389, Example 65-3)
Show SMILES CNC[C@H](O)COc1ccc(Cl)c(c1)-c1nc(N[C@H]2CCN(C[C@H]2F)C(=O)OC)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C27H34ClFN6O5/c1-14-24(23-15(2)34-40-16(23)3)32-26(19-10-18(6-7-20(19)28)39-13-17(36)11-30-4)33-25(14)31-22-8-9-35(12-21(22)29)27(37)38-5/h6-7,10,17,21-22,30,36H,8-9,11-13H2,1-5H3,(H,31,32,33)/t17-,21+,22-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440402
PNG
(US10633389, Example 67-3)
Show SMILES CCS(=O)(=O)N1CCC(CC1)Nc1nc(nc(-c2c(C)noc2C)c1C)-c1cc(OC[C@@H](O)CNC)ccc1Cl
Show InChI InChI=1S/C27H37ClN6O5S/c1-6-40(36,37)34-11-9-19(10-12-34)30-26-16(2)25(24-17(3)33-39-18(24)4)31-27(32-26)22-13-21(7-8-23(22)28)38-15-20(35)14-29-5/h7-8,13,19-20,29,35H,6,9-12,14-15H2,1-5H3,(H,30,31,32)/t20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440404
PNG
(US10633389, Example 69-3)
Show SMILES CNC[C@H](O)COc1ccc(Cl)c(c1)-c1nc(cc(n1)-c1c(C)noc1C)N1CC2(C1)CCN(CC2)C1CC1
Show InChI InChI=1S/C29H37ClN6O3/c1-18-27(19(2)39-34-18)25-13-26(36-16-29(17-36)8-10-35(11-9-29)20-4-5-20)33-28(32-25)23-12-22(6-7-24(23)30)38-15-21(37)14-31-3/h6-7,12-13,20-21,31,37H,4-5,8-11,14-17H2,1-3H3/t21-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440410
PNG
(US10633389, Example 75-3)
Show SMILES CNC[C@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CCC3(CN(C3)S(C)(=O)=O)CC2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C28H37ClN6O5S/c1-17-25(24-18(2)33-40-19(24)3)31-26(22-12-21(6-7-23(22)29)39-14-20(36)13-30-4)32-27(17)34-10-8-28(9-11-34)15-35(16-28)41(5,37)38/h6-7,12,20,30,36H,8-11,13-16H2,1-5H3/t20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440440
PNG
(US10633389, Example 105-3)
Show SMILES CCOC(=O)N1CCC(CC1)Nc1nc(nc(-c2c(C)noc2C)c1C)-c1cc(OC[C@@H](O)CNC)ccc1Cl
Show InChI InChI=1S/C28H37ClN6O5/c1-6-38-28(37)35-11-9-19(10-12-35)31-26-16(2)25(24-17(3)34-40-18(24)4)32-27(33-26)22-13-21(7-8-23(22)29)39-15-20(36)14-30-5/h7-8,13,19-20,30,36H,6,9-12,14-15H2,1-5H3,(H,31,32,33)/t20-/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440455
PNG
(US10633389, Example 120-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CC3(C2)CCOC3)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C26H32ClN5O4/c1-15-23(22-16(2)31-36-17(22)3)29-24(30-25(15)32-12-26(13-32)7-8-34-14-26)20-9-19(5-6-21(20)27)35-11-18(33)10-28-4/h5-6,9,18,28,33H,7-8,10-14H2,1-4H3/t18-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440463
PNG
(US10633389, Example 128-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N[C@H]2CCO[C@@H](C)C2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C26H34ClN5O4/c1-14-10-18(8-9-34-14)29-25-15(2)24(23-16(3)32-36-17(23)4)30-26(31-25)21-11-20(6-7-22(21)27)35-13-19(33)12-28-5/h6-7,11,14,18-19,28,33H,8-10,12-13H2,1-5H3,(H,29,30,31)/t14-,18-,19+/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440469
PNG
(US10633389, Example 134-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(NC[C@H]2COCCN2C(=O)OC(C)C)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C29H39ClN6O6/c1-16(2)41-29(38)36-9-10-39-14-20(36)12-32-27-17(3)26(25-18(4)35-42-19(25)5)33-28(34-27)23-11-22(7-8-24(23)30)40-15-21(37)13-31-6/h7-8,11,16,20-21,31,37H,9-10,12-15H2,1-6H3,(H,32,33,34)/t20-,21+/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440472
PNG
(US10633389, Example 138-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CCC3(CCN(C3)C3CC3)C2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C30H39ClN6O3/c1-18-27(26-19(2)35-40-20(26)3)33-28(24-13-23(7-8-25(24)31)39-15-22(38)14-32-4)34-29(18)37-12-10-30(17-37)9-11-36(16-30)21-5-6-21/h7-8,13,21-22,32,38H,5-6,9-12,14-17H2,1-4H3/t22-,30?/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440478
PNG
(US10633389, Example 144-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N[C@H]2C[C@H](C2)OC)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C25H32ClN5O4/c1-13-23(22-14(2)31-35-15(22)3)29-25(30-24(13)28-16-8-19(9-16)33-5)20-10-18(6-7-21(20)26)34-12-17(32)11-27-4/h6-7,10,16-17,19,27,32H,8-9,11-12H2,1-5H3,(H,28,29,30)/t16-,17-,19+/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440483
PNG
(US10633389, Example 149-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N[C@H]2CCO[C@@H](C)C2)c(Cl)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C25H31Cl2N5O4/c1-13-9-16(7-8-34-13)29-25-22(27)23(21-14(2)32-36-15(21)3)30-24(31-25)19-10-18(5-6-20(19)26)35-12-17(33)11-28-4/h5-6,10,13,16-17,28,33H,7-9,11-12H2,1-4H3,(H,29,30,31)/t13-,16-,17+/m0/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440490
PNG
(US10633389, Example 156-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2Cc3cc(Cl)cnc3C2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C27H28Cl2N6O3/c1-14-25(24-15(2)34-38-16(24)3)32-26(21-8-20(5-6-22(21)29)37-13-19(36)10-30-4)33-27(14)35-11-17-7-18(28)9-31-23(17)12-35/h5-9,19,30,36H,10-13H2,1-4H3/t19-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440492
PNG
(US10633389, Example 158-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CCC3(CN(C3)C3CC3)CC2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C30H39ClN6O3/c1-18-27(26-19(2)35-40-20(26)3)33-28(24-13-23(7-8-25(24)31)39-15-22(38)14-32-4)34-29(18)36-11-9-30(10-12-36)16-37(17-30)21-5-6-21/h7-8,13,21-22,32,38H,5-6,9-12,14-17H2,1-4H3/t22-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440515
PNG
(US10633389, Example 181-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N[C@@H]2CO[C@@H](C)C2)c(Cl)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C24H29Cl2N5O4/c1-12-7-15(10-33-12)28-24-21(26)22(20-13(2)31-35-14(20)3)29-23(30-24)18-8-17(5-6-19(18)25)34-11-16(32)9-27-4/h5-6,8,12,15-16,27,32H,7,9-11H2,1-4H3,(H,28,29,30)/t12-,15-,16+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440523
PNG
(US10633389, Example 189-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(NC2CC(F)(F)C2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C24H28ClF2N5O3/c1-12-21(20-13(2)32-35-14(20)3)30-23(31-22(12)29-15-8-24(26,27)9-15)18-7-17(5-6-19(18)25)34-11-16(33)10-28-4/h5-7,15-16,28,33H,8-11H2,1-4H3,(H,29,30,31)/t16-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440529
PNG
(US10633389, Example 195-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N[C@H]2CCN(C[C@H]2F)C2CC2)c(Cl)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C27H33Cl2FN6O3/c1-14-23(15(2)39-35-14)25-24(29)27(32-22-8-9-36(12-21(22)30)16-4-5-16)34-26(33-25)19-10-18(6-7-20(19)28)38-13-17(37)11-31-3/h6-7,10,16-17,21-22,31,37H,4-5,8-9,11-13H2,1-3H3,(H,32,33,34)/t17-,21-,22+/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440540
PNG
(US10633389, Example 206-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CC(F)C2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C23H27ClFN5O3/c1-12-21(20-13(2)29-33-14(20)3)27-22(28-23(12)30-9-15(25)10-30)18-7-17(5-6-19(18)24)32-11-16(31)8-26-4/h5-7,15-16,26,31H,8-11H2,1-4H3/t16-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440546
PNG
(US10633389, Example 212-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N[C@H]2CC[C@H](C2)OC)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C26H34ClN5O4/c1-14-24(23-15(2)32-36-16(23)3)30-26(31-25(14)29-17-6-7-19(10-17)34-5)21-11-20(8-9-22(21)27)35-13-18(33)12-28-4/h8-9,11,17-19,28,33H,6-7,10,12-13H2,1-5H3,(H,29,30,31)/t17-,18+,19+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440568
PNG
(US10633389, Example 234-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CCC3(CC3)C2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C26H32ClN5O3/c1-15-23(22-16(2)31-35-17(22)3)29-24(30-25(15)32-10-9-26(14-32)7-8-26)20-11-19(5-6-21(20)27)34-13-18(33)12-28-4/h5-6,11,18,28,33H,7-10,12-14H2,1-4H3/t18-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440570
PNG
(US10633389, Example 236-3 | US10633389, Example 23...)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2Cc3c(C)nn(C)c3C2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C27H32ClN7O3/c1-14-25(24-16(3)33-38-17(24)4)30-26(20-9-19(7-8-22(20)28)37-13-18(36)10-29-5)31-27(14)35-11-21-15(2)32-34(6)23(21)12-35/h7-9,18,29,36H,10-13H2,1-6H3/t18-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440577
PNG
(US10633389, Example 243-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2Cc3nc(C)sc3C2)c(Cl)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C25H26Cl2N6O3S/c1-12-21(13(2)36-32-12)23-22(27)25(33-9-19-20(10-33)37-14(3)29-19)31-24(30-23)17-7-16(5-6-18(17)26)35-11-15(34)8-28-4/h5-7,15,28,34H,8-11H2,1-4H3/t15-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM440580
PNG
(US10633389, Example 246-3)
Show SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CC3(CCC3)C2)c(C)c(n1)-c1c(C)noc1C
Show InChI InChI=1S/C26H32ClN5O3/c1-15-23(22-16(2)31-35-17(22)3)29-24(30-25(15)32-13-26(14-32)8-5-9-26)20-10-19(6-7-21(20)27)34-12-18(33)11-28-4/h6-7,10,18,28,33H,5,8-9,11-14H2,1-4H3/t18-/m1/s1
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Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...


US Patent US10633389 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%